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Rapid individual cognitive phenotyping holds the potential to revolutionize domains as wide-ranging as personalized learning, employment practices, and precision psychiatry. Going beyond limitations imposed by traditional lab-based experiments, new efforts have been underway towards greater ecological validity and participant diversity to capture the full range of individual differences in cognitive abilities and behaviors across the general population. Building on this, we developed Skill Lab, a novel game-based tool that simultaneously assesses a broad suite of cognitive abilities while providing an engaging narrative. Skill Lab consists of six mini-games as well as 14 established cognitive ability tasks. Using a popular citizen science platform (N = 10725), we conducted a comprehensive validation in the wild of a game-based cognitive assessment suite. Based on the game and validation task data, we constructed reliable models to simultaneously predict eight cognitive abilities based on the users' in-game behavior. Follow-'-up validation tests revealed that the models can discriminate nuances contained within each separate cognitive ability as well as capture a shared main factor of generalized cognitive ability. Our game-based measures are five times faster to complete than the equivalent task-based measures and replicate previous findings on the decline of certain cognitive abilities with age in our large cross-sectional population sample (N = 6369). Taken together, our results demonstrate the feasibility of rapid in-the-wild systematic assessment of cognitive abilities as a promising first step towards population-scale benchmarking and individualized mental health diagnostics., 24 pages, 8 figures, and 4 tables. Supplementary Information: osf.io/pnw5z//

Membranes not only provide cellular compartmentalization but influence protein behavior and folding by virtue of the multitude of different lipid types. We have studied the impact of lipid composition on the folding of the membrane-associated protein Mistic from B. subtilis. We use dimerisation via the single Cys3 residue as monitor for the degree of correct folding, since mis- or unfolding will expose the otherwise buried Cys3. We find great variability in how lipids affect protein production and dimerization, ranging from high production and low dimerization via increased production and higher dimerization to low production and low dimerization. Phosphocholine (PC) vesicles, in particular di-oleoyl-PC, lead to the highest production levels. Shorter chain lengths lead to reduced production but higher levels of dimerization. Different lipids may promote correct folding of Mistic to different extents, mediated by proper hydrophobic matching (attained for long-chain but not short-chain PC vesicles) and the existence of a fluid phase (the gel phase reduces production as well as dimerization, probably by immobilizing Mistic on the surface). The very fact that different lipids have an effect indicates that Mistic behaves like a bona fide membrane protein with a clear preference for membranes of a certain thickness and flexibility.

In higher education (HE), science and technology (STEM) institutions were early adopters of entrepreneurship education, recognizing that STEM majors in particular have a disproportional potential to form high-growth ventures in high-tech industries with high-value prospects. Yet, only limited empirical work has been carried out to shed light on how these programs are developed and how and why they are designed and organized the way that they are. What we do know typically comes to us from single-case reports on isolated programs. This study aims to provide deeper insights through an innovative and comprehensive research design that provides a way to compare and contrast case studies of five programs, developed by different educators, in different Nordic nations, and at different HE STEM institutions. The study mainly aims to explore how these cross-case and cross-national studies can guide future entrepreneurship education program development. However, considering the deliberate selection of comparable cases, this study finds a striking diversity in effective and successful programs, and uncovers strong interdependencies between program design and inception and the program developers. As such, in addition to providing guidance for program developers, the study identifies implications for other stakeholders, including students, university management, and entrepreneurship education research.

Mutations in the human TGFBI gene encoding TGFBIp have been linked to protein deposits in the cornea leading to visual impairment. The protein consists of an N-terminal Cys-rich EMI domain and four consecutive fasciclin 1 (FAS1) domains. We have compared the stabilities of wild-type (WT) human TGFBIp and six mutants known to produce phenotypically distinct deposits in the cornea. Amino acid substitutions in the first FAS1 (FAS1-1) domain (R124H, R124L, and R124C) did not alter the stability. However, substitutions within the fourth FAS1 (FAS1-4) domain (A546T, R555Q, and R555W) affected the overall stability of intact TGFBIp revealing the following stability ranking R555W>WT>R555Q>A546T. Significantly, the stability ranking of the isolated FAS1-4 domains mirrored the behavior of the intact protein. In addition, it was linked to the aggregation propensity as the least stable mutant (A546T) forms amyloid fibrils while the more stable variants generate non-amyloid amorphous deposits in vivo. Significantly, the data suggested that both an increase and a decrease in the stability of FAS1-4 may unleash a disease mechanism. In contrast, amino acid substitutions in FAS1-1 did not affect the stability of the intact TGFBIp suggesting that molecular the mechanism of disease differs depending on the FAS1 domain carrying the mutation.

Quantum Moves is a citizen science game that investigates the ability of humans to solve complex physics challenges that are intractable for computers. During the launch of Quantum Moves in April 2016 the game's leaderboard function broke down resulting in a "no leaderboard" game experience for some players for a couple of days (though their scores were still displayed). The subsequent quick fix of an all-time Top 5 leaderboard, and the following long-term implementation of a personalized relative-position (infinite) leaderboard provided us with a unique opportunity to compare and investigate the effect of different leaderboard implementations on player performance in a points-driven citizen science game. All three conditions were live sequentially during the game's initial influx of more than 150.000 players that stemmed from global press attention on Quantum Moves due the publication of a Nature paper about the use of Quantum Moves in solving a specific quantum physics problem. Thus, it has been possible to compare the three conditions and their influence on the performance (defined as a player's quality of game play related to a high-score) of over 4500 new players. These 4500 odd players in our three leaderboard-conditions have a similar demographic background based upon the time-window over which the implementations occurred and controlled against Player ID tags. Our results placed Condition 1 experience over condition 3 and in some cases even over condition 2 which goes against the general assumption that leaderboards enhance gameplay and its subsequent overuse as a an oft-relied upon element that designers slap onto a game to enhance said appeal. Our study thus questions the use of leaderboards as general performance enhancers in gamification contexts and brings some empirical rigor to an often under-reported but overused phenomenon., 8 pages, 3 figures, accepted for publication at ECGBL