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1. Erratum to: Building bridges for innovation in ageing: Synergies between action groups of the EIP on AHA

Author

Bousquet, Jean, Bewick, M., Cano, A., Eklund, P., Fico, G., Goswami, N., Guldemond, N. A., Henderson, D., Hinkema, M. J., Liotta, G., Mair, A., Molloy, W., Monaco, A., Monsonis-Paya, I., Nizinska, A., Papadopoulos, H., Pavlickova, A., Pecorelli, S., Prados-Torres, A., Roller-Wirnsberger, R. E., Somekh, D., Vera-Muñoz, C., Visser, F., Farrell, J., Malva, J., Andersen Ranberg, K., Camuzat, T., Carriazo, A. M., Crooks, G., Gutter, Z., Iaccarino, G., de Keenoy, E. Manuel, Moda, G., Rodriguez-Mañas, L., Vontetsianos, T., Abreu, C., Alonso, J., Alonso-Bouzon, C., Ankri, J., Arredondo, M. T., Avolio, F., Bedbrook, A., Białoszewski, A. Z., Blain, H., Bourret, R., Cabrera-Umpierrez, M. F., Catala, A., O’Caoimh, R., Cesari, M., Chavannes, N. H., Correia-Da-Sousa, J., Dedeu, T., Ferrando, M., Ferri, M., Fokkens, W. J., Garcia-Lizana, F., Guérin, O., Hellings, P. W., Haahtela, T., Illario, M., Inzerilli, M. C., Lodrup Carlsen, K. C., Kardas, P., Keil, T., Maggio, M., Mendez-Zorrilla, A., Menditto, E., Mercier, J., Michel, J. P., Murray, R., Nogues, M., O’Byrne-Maguire, I., Pappa, D., Parent, A. S., Pastorino, M., Robalo-Cordeiro, C., Samolinski, B., Siciliano, P., Teixeira, A. M., Tsartara, S. I., Valiulis, A., Vandenplas, O., Vasankari, T., Vellas, B., Vollenbroek-Hutten, M., Wickman, M., Yorgancioglu, A., Zuberbier, T., Barbagallo, M., Canonica, G. W., Klimek, L., Maggi, S., Aberer, W., Akdis, C., Adcock, I. M., Agache, I., Albera, C., Alonso-Trujillo, F., Angel Guarcia, M., Annesi-Maesano, I., Apostolo, J., Arshad, S. H., Attalin, V., Avignon, A., Bachert, C., Baroni, I., Bel, E., Benson, M., Bescos, C., Blasi, F., Barbara, C., Bergmann, K. C., Bernard, P. L., Bonini, S., Bousquet, P. J., Branchini, B., Brightling, C. E., Bruguière, V., Bunu, C., Bush, A., Caimmi, D. P., Calderon, M. A., Canovas, G., Cardona, V., Carlsen, K. H., Cesario, A., Chkhartishvili, E., Chiron, R., Chivato, T., Chung, K. F., D’Angelantonio, M., de Carlo, G., Cholley, D., Chorin, F., Combe, B., Compas, B., Costa, D. J., Costa, E., Coste, O., Coupet, A. -L., Crepaldi, G., Custovic, A., Dahl, R., Dahlen, S. E., Demoly, P., Devillier, P., Didier, A., Dinh-Xuan, A. T., Djukanovic, R., Dokic, D., du Toit, G., Dubakiene, R., Dupeyron, A., Emuzyte, R., Fiocchi, A., Wagner, A., Fletcher, M., Fonseca, J., Fougère, B., Gamkrelidze, A., Garces, G., Garcia-Aymeric, J., Garcia-Zapirain, B., Gemicioğlu, B., Gouder, C., Hellquist-Dahl, B., Hermosilla-Gimeno, I., Héve, D., Holland, C., Humbert, M., Hyland, M., Johnston, S. L., Just, J., Jutel, M., Kaidashev, I. P., Kaitov, M., Kalayci, O., Kalyoncu, A. F., Keijser, W., Kerstjens, H., Knezović, J., Kowalski, M., Koppelman, G. H., Kotska, T., Kovac, M., Kull, I., Kuna, P., Kvedariene, V., Lepore, V., Macnee, W., Maggio, M., Magnan, A., Majer, I., Manning, P., Marcucci, M., Marti, T., Masoli, M., Melen, E., Miculinic, N., Mihaltan, F., Milenkovic, B., Millot-Keurinck, J., Mlinarić, H., Momas, I., Montefort, S., Morais-Almeida, M., Moreno-Casbas, T., Mösges, R., Mullol, J., Nadif, R., Nalin, M., Navarro-Pardo, E., Nekam, K., Ninot, G., Paccard, D., Pais, S., Palummeri, E., Panzner, P., Papadopoulos, N. K., Papanikolaou, C., Passalacqua, G., Pastor, E., Perrot, M., Plavec, D., Popov, T. A., Postma, D. S., Price, D., Raffort, N., Reuzeau, J. C., Robine, J. M., Rodenas, F., Robusto, F., Roche, N., Romano, A., Romano, V., Rosado-Pinto, J., Roubille, F., Ruiz, F., Ryan, D., Salcedo, T., Schmid-Grendelmeier, P., Schulz, H., Schunemann, H. J., Serrano, E., Sheikh, A., Shields, M., Siafakas, N., Scichilone, N., Siciliano, P., Skrindo, I., Smit, H. A., Sourdet, S., Sousa-Costa, E., Spranger, O., Sooronbaev, T., Sruk, V., Sterk, P. J., Todo-Bom, A., Touchon, J., Tramontano, D., Triggiani, M., Tsartara, S. I., Valero, A. L., Valovirta, E., van Ganse, E., van Hage, M., van den Berge, M., Vandenplas, O., Ventura, M. T., Vergara, I., Vezzani, G., Vidal, D., Viegi, G., Wagemann, M., Whalley, B., Wickman, M., Wilson, N., Yiallouros, P. K., Žagar, M., Zaidi, A., Zidarn, M., Hoogerwerf, E. J., Usero, J., Zuffada, R., Senn, A., and de Oliveira-Alves, B.

Published
2023
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2. Building bridges for innovation in ageing: Synergies between action groups of the EIP on AHA

Author

Bousquet, Jean, Bewick, M., Cano, A., Eklund, P., Fico, G., Goswami, N., Guldemond, N. A., Henderson, D., Hinkema, M. J., Liotta, G., Mair, A., Molloy, W., Monaco, A., Monsonis-Paya, I., Nizinska, A., Papadopoulos, H., Pavlickova, A., Pecorelli, S., Prados-Torres, A., Roller-Wirnsberger, R. E., Somekh, D., Vera-Muñoz, C., Visser, F., Farrell, J., Malva, J., Andersen Ranberg, K., Camuzat, T., Carriazo, A. M., Crooks, G., Gutter, Z., Iaccarino, G., de Keenoy, E. Manuel, Moda, G., Rodriguez-Mañas, L., Vontetsianos, T., Abreu, C., Alonso, J., Alonso-Bouzon, C., Ankri, J., Arredondo, M. T., Avolio, F., Bedbrook, A., Białoszewski, A. Z., Blain, H., Bourret, R., Cabrera-Umpierrez, M. F., Catala, A., O’Caoimh, R., Cesari, M., Chavannes, N. H., Correia-Da-Sousa, J., Dedeu, T., Ferrando, M., Ferri, M., Fokkens, W. J., Garcia-Lizana, F., Guérin, O., Hellings, P. W., Haahtela, T., Illario, M., Inzerilli, M. C., Lodrup Carlsen, K. C., Kardas, P., Keil, T., Maggio, M., Mendez-Zorrilla, A., Menditto, E., Mercier, J., Michel, J. P., Murray, R., Nogues, M., O’Byrne-Maguire, I., Pappa, D., Parent, A. S., Pastorino, M., Robalo-Cordeiro, C., Samolinski, B., Siciliano, P., Teixeira, A. M., Tsartara, S. I., Valiulis, A., Vandenplas, O., Vasankari, T., Vellas, B., Vollenbroek-Hutten, M., Wickman, M., Yorgancioglu, A., Zuberbier, T., Barbagallo, M., Canonica, G. W., Klimek, L., Maggi, S., Aberer, W., Akdis, C., Adcock, I. M., Agache, I., Albera, C., Alonso-Trujillo, F., Angel Guarcia, M., Annesi-Maesano, I., Apostolo, J., Arshad, S. H., Attalin, V., Avignon, A., Bachert, C., Baroni, I., Bel, E., Benson, M., Bescos, C., Blasi, F., Barbara, C., Bergmann, K. C., Bernard, P. L., Bonini, S., Bousquet, P. J., Branchini, B., Brightling, C. E., Bruguière, V., Bunu, C., Bush, A., Caimmi, D. P., Calderon, M. A., Canovas, G., Cardona, V., Carlsen, K. H., Cesario, A., Chkhartishvili, E., Chiron, R., Chivato, T., Chung, K. F., D’Angelantonio, M., de Carlo, G., Cholley, D., Chorin, F., Combe, B., Compas, B., Costa, D. J., Costa, E., Coste, O., Coupet, A. -L., Crepaldi, G., Custovic, A., Dahl, R., Dahlen, S. E., Demoly, P., Devillier, P., Didier, A., Dinh-Xuan, A. T., Djukanovic, R., Dokic, D., du Toit, G., Dubakiene, R., Dupeyron, A., Emuzyte, R., Fiocchi, A., Wagner, A., Fletcher, M., Fonseca, J., Fougère, B., Gamkrelidze, A., Garces, G., Garcia-Aymeric, J., Garcia-Zapirain, B., Gemicioğlu, B., Gouder, C., Hellquist-Dahl, B., Hermosilla-Gimeno, I., Héve, D., Holland, C., Humbert, M., Hyland, M., Johnston, S. L., Just, J., Jutel, M., Kaidashev, I. P., Kaitov, M., Kalayci, O., Kalyoncu, A. F., Keijser, W., Kerstjens, H., Knezović, J., Kowalski, M., Koppelman, G. H., Kotska, T., Kovac, M., Kull, I., Kuna, P., Kvedariene, V., Lepore, V., Macnee, W., Maggio, M., Magnan, A., Majer, I., Manning, P., Marcucci, M., Marti, T., Masoli, M., Melen, E., Miculinic, N., Mihaltan, F., Milenkovic, B., Millot-Keurinck, J., Mlinarić, H., Momas, I., Montefort, S., Morais-Almeida, M., Moreno-Casbas, T., Mösges, R., Mullol, J., Nadif, R., Nalin, M., Navarro-Pardo, E., Nekam, K., Ninot, G., Paccard, D., Pais, S., Palummeri, E., Panzner, P., Papadopoulos, N. K., Papanikolaou, C., Passalacqua, G., Pastor, E., Perrot, M., Plavec, D., Popov, T. A., Postma, D. S., Price, D., Raffort, N., Reuzeau, J. C., Robine, J. M., Rodenas, F., Robusto, F., Roche, N., Romano, A., Romano, V., Rosado-Pinto, J., Roubille, F., Ruiz, F., Ryan, D., Salcedo, T., Schmid-Grendelmeier, P., Schulz, H., Schunemann, H. J., Serrano, E., Sheikh, A., Shields, M., Siafakas, N., Scichilone, N., Siciliano, P., Skrindo, I., Smit, H. A., Sourdet, S., Sousa-Costa, E., Spranger, O., Sooronbaev, T., Sruk, V., Sterk, P. J., Todo-Bom, A., Touchon, J., Tramontano, D., Triggiani, M., Tsartara, S. I., Valero, A. L., Valovirta, E., van Ganse, E., van Hage, M., van den Berge, M., Vandenplas, O., Ventura, M. T., Vergara, I., Vezzani, G., Vidal, D., Viegi, G., Wagemann, M., Whalley, B., Wickman, M., Wilson, N., Yiallouros, P. K., Žagar, M., Zaidi, A., Zidarn, M., Hoogerwerf, E. J., Usero, J., Zuffada, R., Senn, A., and de Oliveira-Alves, B.

Published
2017
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10. Paving the way of systems biology and precision medicine in allergic diseases

Author

University of Helsinki, Clinicum, University of Helsinki, Departments of Dermatology, Allergology and Venereology, Bousquet, J., Anto, J. M., Akdis, M., Auffray, C., Keil, T., Momas, I., Postma, D. S., Valenta, R., Wickman, M., Cambon-Thomsen, A., Haahtela, T., Lambrecht, B. N., Carlsen, K. C. Lodrup, Koppelman, G. H., Sunyer, J., Zuberbier, T., Annesi-Maesano, I., Arno, A., Bindslev-Jensen, C., De Carlo, G., Forastiere, F., Heinrich, J., Kowalski, M. L., Maier, D., Melen, E., Palkonen, S., Smit, H. A., Standl, M., Wright, J., Asarnoj, A., Benet, M., Ballardini, N., Garcia-Aymerich, J., Gehring, U., Guerra, S., Hohman, C., Kull, I., Lupinek, C., Pinart, M., Skrindo, I., Westman, M., Smagghe, D., Akdis, C., Albang, R., Anastasova, V., Anderson, N., Bachert, C., Ballereau, S., Ballester, F., Basagana, X., Bedbrook, A., Bergstrom, A., von Berg, A., Brunekreef, B., Burte, E., Carlsen, K. H., Chatzi, L., Coquet, J. M., Curin, M., Demoly, P., Eller, E., Fantini, M. P., Gerhard, B., Hammad, H., von Hertzen, L., Hovland, V., Jacquemin, B., Just, J., Keller, T., Kerkhof, M., Kiss, R., Kogevinas, M., Koletzko, S., Lau, S., Lehmann, I., Lemonnier, N., McEachan, R., Mäkelä, M., Mestres, J., Minina, E., Mowinckel, P., Nadif, R., Nawijn, M., Oddie, S., Pellet, J., Pin, I., Porta, D., Ranciere, F., Rial-Sebbag, A., Saeys, Y., Schuijs, M. J., Siroux, V., Tischer, C. G., Torrent, M., Varraso, R., De Vocht, J., Wenger, K., Wieser, S., Xu, C., University of Helsinki, Clinicum, University of Helsinki, Departments of Dermatology, Allergology and Venereology, Bousquet, J., Anto, J. M., Akdis, M., Auffray, C., Keil, T., Momas, I., Postma, D. S., Valenta, R., Wickman, M., Cambon-Thomsen, A., Haahtela, T., Lambrecht, B. N., Carlsen, K. C. Lodrup, Koppelman, G. H., Sunyer, J., Zuberbier, T., Annesi-Maesano, I., Arno, A., Bindslev-Jensen, C., De Carlo, G., Forastiere, F., Heinrich, J., Kowalski, M. L., Maier, D., Melen, E., Palkonen, S., Smit, H. A., Standl, M., Wright, J., Asarnoj, A., Benet, M., Ballardini, N., Garcia-Aymerich, J., Gehring, U., Guerra, S., Hohman, C., Kull, I., Lupinek, C., Pinart, M., Skrindo, I., Westman, M., Smagghe, D., Akdis, C., Albang, R., Anastasova, V., Anderson, N., Bachert, C., Ballereau, S., Ballester, F., Basagana, X., Bedbrook, A., Bergstrom, A., von Berg, A., Brunekreef, B., Burte, E., Carlsen, K. H., Chatzi, L., Coquet, J. M., Curin, M., Demoly, P., Eller, E., Fantini, M. P., Gerhard, B., Hammad, H., von Hertzen, L., Hovland, V., Jacquemin, B., Just, J., Keller, T., Kerkhof, M., Kiss, R., Kogevinas, M., Koletzko, S., Lau, S., Lehmann, I., Lemonnier, N., McEachan, R., Mäkelä, M., Mestres, J., Minina, E., Mowinckel, P., Nadif, R., Nawijn, M., Oddie, S., Pellet, J., Pin, I., Porta, D., Ranciere, F., Rial-Sebbag, A., Saeys, Y., Schuijs, M. J., Siroux, V., Tischer, C. G., Torrent, M., Varraso, R., De Vocht, J., Wenger, K., Wieser, S., and Xu, C.

Abstract

MeDALL (Mechanisms of the Development of ALLergy; EU FP7-CP-IP; Project No: 261357; 2010-2015) has proposed an innovative approach to develop early indicators for the prediction, diagnosis, prevention and targets for therapy. MeDALL has linked epidemiological, clinical and basic research using a stepwise, large-scale and integrative approach: MeDALL data of precisely phenotyped children followed in 14 birth cohorts spread across Europe were combined with systems biology (omics, IgE measurement using microarrays) and environmental data. Multimorbidity in the same child is more common than expected by chance alone, suggesting that these diseases share causal mechanisms irrespective of IgE sensitization. IgE sensitization should be considered differently in monosensitized and polysensitized individuals. Allergic multimorbidities and IgE polysensitization are often associated with the persistence or severity of allergic diseases. Environmental exposures are relevant for the development of allergy-related diseases. To complement the population-based studies in children, MeDALL included mechanistic experimental animal studies and in vitro studies in humans. The integration of multimorbidities and polysensitization has resulted in a new classification framework of allergic diseases that could help to improve the understanding of genetic and epigenetic mechanisms of allergy as well as to better manage allergic diseases. Ethics and gender were considered. MeDALL has deployed translational activities within the EU agenda.

Published
2016

13. The sex‐shift in single disease and multimorbid asthma and rhinitis during puberty:a study by MeDALL

Author

Keller, T, Hohmann, C, Standl, M, Wijga, A H, Gehring, U, Melén, E, Almqvist, C, Lau, S, Eller, E, Wahn, U, Christiansen, E S, von Berg, A, Heinrich, J, Lehmann, I, Maier, D, Postma, D S, Antó, J M, Bousquet, J, Keil, T, Roll, S, One Health Chemisch, dIRAS RA-2, LS IRAS EEPI ME (Milieu epidemiologie), Geneeskunde van gezelschapsdieren, Charité - UniversitätsMedizin = Charité - University Hospital [Berlin], Centre Hospitalier Régional Universitaire [Montpellier] (CHRU Montpellier), Contre les MAladies Chroniques pour un VIeillissement Actif en Languedoc-Roussillon (MACVIA-LR), Centre Hospitalier Régional Universitaire [Montpellier] (CHRU Montpellier)-Université Montpellier 1 (UM1)-Centre Hospitalier Universitaire de Nîmes (CHU Nîmes)-European Innovation Partnership on Active and Healthy Ageing Reference Site (EIP on AHA), Commission Européenne-Commission Européenne-Organisation Mondiale de la Santé / World Health Organization Office (OMS / WHO)-Centre National de la Recherche Scientifique (CNRS)-Institut National de la Santé et de la Recherche Médicale (INSERM)-Université de Montpellier (UM), Universitat Pompeu Fabra [Barcelona] (UPF), Vieillissement et Maladies chroniques : approches épidémiologique et de santé publique (VIMA), Institut National de la Santé et de la Recherche Médicale (INSERM)-Université de Versailles Saint-Quentin-en-Yvelines (UVSQ), Université Montpellier 1 (UM1)-Centre Hospitalier Régional Universitaire [Montpellier] (CHRU Montpellier)-Institut National de la Santé et de la Recherche Médicale (INSERM)-Centre Hospitalier Universitaire de Nîmes (CHU Nîmes)-Université de Montpellier (UM)-Centre National de la Recherche Scientifique (CNRS)-European Innovation Partnership on Active and Healthy Ageing Reference Site (EIP on AHA), Commission Européenne-Commission Européenne-Organisation Mondiale de la Santé / World Health Organization Office (OMS / WHO), Université de Versailles Saint-Quentin-en-Yvelines (UVSQ)-Institut National de la Santé et de la Recherche Médicale (INSERM), Groningen Research Institute for Asthma and COPD (GRIAC), One Health Chemisch, dIRAS RA-2, LS IRAS EEPI ME (Milieu epidemiologie), and Geneeskunde van gezelschapsdieren

Subjects
CHILDHOOD ISAAC, Male, puberty, CHILDREN, Disease, Comorbidity, Cohort Studies, 0302 clinical medicine, ALLERGIC DISEASES, Prevalence, Immunology and Allergy, Sexual Maturation, 030212 general & internal medicine, [SDV.IMM.ALL]Life Sciences [q-bio]/Immunology/Allergology, Rhinitis, Allergic/epidemiology, Sexual Maturation/immunology, media_common, Sex Characteristics, birth cohort, 3. Good health, PREVALENCE, Natural history, ADOLESCENCE, Original Article, Female, Allergic Multimorbidity, Asthma, Birth Cohort, Puberty, Rhinitis, Birth cohort, medicine.medical_specialty, Adolescent, Immunology, ECZEMA, 03 medical and health sciences, Young Adult, AGE, rhinitis, medicine, Journal Article, media_common.cataloged_instance, Humans, Puberty/immunology, Epidemiology and Genetics, European union, GENDER-DIFFERENCES, [SDV.MHEP.PED]Life Sciences [q-bio]/Human health and pathology/Pediatrics, business.industry, NATURAL-HISTORY, asthma, medicine.disease, Rhinitis, Allergic, 030228 respiratory system, Family medicine, Asthma/epidemiology, [SDV.SPEE]Life Sciences [q-bio]/Santé publique et épidémiologie, ORIGINAL ARTICLES, business, allergic multimorbidity, Work Programme
Abstract

Background - Cross‐sectional studies suggested that allergy prevalence in childhood is higher in boys compared to girls, but it remains unclear whether this inequality changes after puberty. We examined the sex‐specific prevalence of asthma and rhinitis as single and as multimorbid diseases before and after puberty onset in longitudinal cohort data. Methods - In six European population‐based birth cohorts of MeDALL, we assessed the outcomes: current rhinitis, current asthma, current allergic multimorbidity (ie, concurrent asthma and rhinitis), puberty status and allergic sensitization by specific serum antibodies (immunoglobulin E) against aero‐allergens. With generalized estimating equations, we analysed the effects of sex, age, puberty (yes/no) and possible confounders on the prevalence of asthma and rhinitis, and allergic multimorbidity in each cohort separately and performed individual participant data meta‐analysis. Findings - We included data from 19 013 participants from birth to age 14‐20 years. Current rhinitis only affected girls less often than boys before and after puberty onset: adjusted odds ratio for females vs males 0.79 (95%‐confidence interval 0.73‐0.86) and 0.86 (0.79‐0.94), respectively (sex‐puberty interaction P = .089). Similarly, for current asthma only, females were less often affected than boys both before and after puberty onset: 0.71, 0.63‐0.81 and 0.81, 0.64‐1.02, respectively (sex‐puberty interaction P = .327). The prevalence of allergic multimorbidity showed the strongest sex effect before puberty onset (female‐male‐OR 0.55, 0.46‐0.64) and a considerable shift towards a sex‐balanced prevalence after puberty onset (0.89, 0.74‐1.04); sex‐puberty interaction: P < .001. Interpretation - The male predominance in prevalence before puberty and the “sex‐shift” towards females after puberty onset were strongest in multimorbid patients who had asthma and rhinitis concurrently. European Union under the Health Cooperation Work Programme of the 7th Framework Programme. Grant Number: 261357

Published
2018
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17. Functional Translation of IL33 Locus Polymorphisms Into Altered Epithelial Cell Function Underlying Asthma

Author

Ketelaar, M., Portelli, M. A., Dijk, F. N., Faiz, A., Shrine, N., Hankinson, J., Bhaker, S., Henry, A. P., Billington, C. K., Shaw, D., Johnson, S. R., Benest, A. V., Pogson, Z. E. K., Fogarty, A., McKeever, T. M., Singapuri, A., Heaney, L., Mansur, A., Gaudhuri, R., Thomson, N. C., Holloway, J. W., Lockett, G. A., Howarth, P. H., Niven, R., Simpson, A., Tobin, M. D., Postma, D. S., Hall, I. P., Wain, L. V., Brightling, C. E., Obeidat, M., Sin, D. D., van den Berge, M., Koppelman, G. H., Sayers, I., Nawijn, M. C., and Groningen Research Institute for Asthma and COPD (GRIAC)

Published
2019

23. Scaling up strategies of the chronic respiratory disease programme of the European Innovation Partnership on Active and Healthy Ageing (Action Plan B3: Area 5)

Author

Bousquet, Jean, Farrell, J., Crooks, George, Hellings, P. W., Bel, E. H., Bewick, M., Chavannes, Niels H., Sousa, J. Correia de, Cruz, A. A., Haahtela, T., Joos, G., Khaltaev, N., Malva, J., Muraro, A., Nogues, M., Palkonen, S., Pedersen, S., Robalo-Cordeiro, C., Samolinski, B., Strandberg, T., Valiulis, A., Yorgancioglu, A., Zuberbier, T., Bedbrook, Anna, Aberer, W., Adachi, M., Agusti, A., Akdis, C. A., Akdis, M., Ankri, J., Alonso, A., Annesi-Maesano, I., Ansotegui, I. J., Anto, Josep M., Arnavielhe, S., Arshad, S. H., Bai, C., Baiardini, I., Bachert, C., Baigenzhin, A. K., Barbara, Cristina, Bateman, E. D., Beghé, B., Kheder, A. B., Bennoor, K. S., Benson, M., Bergmann, K. C., Bieber, T., Bindslev-Jensen, C., Bjermer, L., Blain, Hubert, Blasi, F., Boner, A. L., Bonini, M., Bonini, S., Bosnic-Anticevitch, S., Boulet, L. P., Bourret, Rodolphe, Braido, F., Briggs, A. H., Brightling, C. E., Brozek, J. L., Buhl, R., Burney, P. G., Bush, A., Caballero-Fonseca, F., Caimmi, D. P., Calderon, M. A., Calverley, P. M., Camargos, P. A. M., Canonica, G. W., Camuzat, Thierry, Carlsen, K. H., Carr, W., Carriazo, A. M., Casale, T. B., A.M, Cepeda Sarabia, Chatzi, L., Chen, Y. Z., Chiron, R., Chkhartishvili, E., Chuchalin, Alexander G., Chung, K. F., Ciprandi, G., Cirule, I., Cox, L., Costa, David J., Custovic, Adnan, Dahl, R., Dahlen, S. E., Darsow, U., Carlo, G. De, Blay, F. De, Dedeu, Antoni, Deleanu, D., Keenoy, E. De Manuel, Demoly, Pascal, Denburg, J. A., Devillier, P., Didier, A., Dinh-Xuan, A. T., Djukanovic, R., Dokic, D., Douagui, H. B., Dray, G., Dubakiene, R., Durham, S. R., Dykewicz, M. S., El-Gamal, Y., Emuzyte, R., Fabbri, Leonardo M., Fletcher, M., Fiocchi, A., Fink-Wagner, A., Fonseca, J. A., Fokkens, W. J., Forastiere, F., Frith, P., Gaga, M., Gamkrelidze, A., Garces, J., Garcia-Aymerich, Judith, Gemicioǧlu, B., Gereda, J. E., Diaz, S. González, Gotua, M., Grisle, I., Grouse, L., Gutter, Z., Guzmán, M. A., Heaney, L. G., Hellquist-Dahl, B., Henderson, D., Hendry, A., Heinrich, J., Heve, D., Horak, F., Hourihane, J. O. B., Howarth, P. H., Humbert, M., Hyland, M. E., Illario, M., Ivancevich, J. C., Jardim, J. R., Jares, E. J., Jeandel, Claude, Jenkins, C., Johnston, S. L., Jonquet, Olivier, Julge, K., Jung, K. S., Just, J., Kaidashev, I. P., Kaitov, M. R., Kalayci, O., Kalyoncu, A. F., Keil, T., Keith, P. K., Klimek, L., N'Goran, B. Koffi, Kolek, V., Koppelman, G. H., Kowalski, M. L., Kull, I., Kuna, P., Kvedariene, V., Lambrecht, B., Lau, S., Larenas-Linnemann, D., Laune, D., Le, Tuyen D., Lieberman, P., Lipworth, B. J., Li, J., Carlsen, K. C. Lodrup, Louis, R., MacNee, W., Magard, Y., Magnan, A., Mahboub, B., Mair, A., Majer, I., Makela, M. J., Manning, P. J., Mara, S., Marshall, G. D., Masjedi, M. R., Matignon, P., Maurer, M., Mavale-Manuel, S., Melén, E., Gomes, Elisabete Melo, Meltzer, E. O., Menzies-Gow, A., Merk, H., Michel, J. P., Miculinic, N., Mihaltan, F., Milenkovic, B., Mohammad, G. M. Y., Molimard, M., Momas, I., Montilla-Santana, A., Almeida, M. Morais, Morgan, M., Mosges, R., Mullol, J., Nafti, S., Namazova-Baranova, L., Naclerio, R. N., Neou, A., Neffen, H., Nekam, K., Niggemann, B., Ninot, G., Nyembue, T. D., O'Hehir, R. E., Ohta, K., Okamoto, Y., Okubo, K., Ouedraogo, S., Paggiaro, P. L., Pali-Schöll, I., Panzner, P., Papadopoulos, N., Papi, A., Park, H. S., Passalacqua, G., Pavord, I., Pawankar, R., Pengelly, R., Pfaar, O., Picard, R., Pigearias, B., Pin, I., Plavec, D., Poethig, D., Pohl, W., Popov, T. A., Portejoie, F., Potter, P., Postma, D. S., Price, D., Rabe, K. F., Raciborski, F., Radier-Pontal, F., Repka-Ramirez, S., Reitamo, S., Rennard, S., Rodenas, F., Roberts, J., Roca, J., Rodriguez-Mañas, L., Rolland, C., Rodriguez, M. Roman, Romano, A., Rosado-Pinto, J., Rosario, N. A., Rosenwasser, L., Rottem, M., Ryan, D., Sanchez-Borges, M., Scadding, G. K., Schunemann, H. J., Serrano, E., Schmid-Grendelmeier, P., Schulz, H., Sheikh, A., Shields, K. M., Siafakas, N., Sibille, Y., Similowski, T., Simons, F. E. R., Sisul, J. C., Skrindo, I., Smit, H. A., Sole, D., Sooronbaev, T., Spranger, O., Stelmach, R., Sterk, P. J., Sunyer, Jordi, Thijs, C., To, T., Todo-Bom, A., Triggiani, M., Valenta, R., Valero, A. L., Valia, E., Valovirta, E., Ganse, E. Van, Hage, M. van, Vandenplas, O., Vasankari, T., Vellas, B., Vestbo, J., Vezzani, G., Vichyanond, P., Viegi, Giovanni, Vogelmeier, C., Vontetsianos, T., Wagenmann, M., Wallaert, B., Walker, S., Wang, D. Y., Wahn, U., Wickman, M., Williams, D. M., Williams, S., Wright, J., Yawn, B. P., Yiallouros, Panayiotis K., Yusuf, O. M., Zaidi, A., Zar, H. J., Zernotti, M. E., Zhang, L., Zhong, N., Zidarn, M., Mercier, Jacques, Bousquet, J, Farrell, J, Crooks, G, Hellings, P, Bel, E. H, Bewick, M, Chavannes, N. H, de Sousa, J. Correia, Cruz, A. A, Haahtela, T, Joos, G, Khaltaev, N, Malva, J, Muraro, A, Nogues, M, Palkonen, S, Pedersen, S, Robalo Cordeiro, C, Samolinski, B, Strandberg, T, Valiulis, A, Yorgancioglu, A, Zuberbier, T, Bedbrook, A, Aberer, W, Adachi, M, Agusti, A, Akdis, C. A, Akdis, M, Ankri, J, Alonso, A, Annesi Maesano, I, Ansotegui, I. J, Anto, J. M, Arnavielhe, S, Arshad, H, Bai, C, Baiardini, I, Bachert, C, Baigenzhin, A. K, Barbara, C, Bateman, E. D, Beghé, B, Kheder, A. Ben, Bennoor, K. S, Benson, M, Bergmann, K. C, Bieber, T, Bindslev Jensen, C, Bjermer, L, Blain, H, Blasi, F, Boner, A. L, Bonini, M, Bonini, Sergio, Bosnic Anticevitch, S, Boulet, L. P, Bourret, R, Bousquet, P. J, Braido, F, Briggs, A. H, Brightling, C. E, Brozek, J, Buhl, R, Burney, P. G, Bush, A, Caballero Fonseca, F, Caimmi, D, Calderon, M. A, Calverley, P. M, Camargos, P. A. M, Canonica, G. W, Camuzat, T, Carlsen, K. H, Carr, W, Carriazo, A, Casale, T, Cepeda Sarabia, A. M, Chatzi, L, Chen, Y. Z, Chiron, R, Chkhartishvili, E, Chuchalin, A. G, Chung, K. F, Ciprandi, G, Cirule, I, Cox, L, Costa, D. J, Custovic, A, Dahl, R, Dahlen, S. E, Darsow, U, De Carlo, G, De Blay, F, Dedeu, T, Deleanu, D, De Manuel Keenoy, E, Demoly, P, Denburg, J. A, Devillier, P, Didier, A, Dinh Xuan, A. T, Djukanovic, R, Dokic, D, Douagui, H, Dray, G, Dubakiene, R, Durham, S. R, Dykewicz, M. S, El Gamal, Y, Emuzyte, R, Fabbri, L. M, Fletcher, M, Fiocchi, A, Fink Wagner, A, Fonseca, J, Fokkens, W. J, Forastiere, F, Frith, P, Gaga, M, Gamkrelidze, A, Garces, J, Garcia Aymerich, J, Gemicioğlu, B, Gereda, J. E, González Diaz, S, Gotua, M, Grisle, I, Grouse, L, Gutter, Z, Guzmán, M. A, Heaney, L. G, Hellquist Dahl, B, Henderson, D, Hendry, A, Heinrich, J, Heve, D, Horak, F, Hourihane, J. O' B, Howarth, P, Humbert, M, Hyland, M. E, Illario, M, Ivancevich, J. C, Jardim, J. R, Jares, E. J, Jeandel, C, Jenkins, C, Johnston, S. L, Jonquet, O, Julge, K, Jung, K. S, Just, J, Kaidashev, I, Kaitov, M. R, Kalayci, O, Kalyoncu, A. F, Keil, T, Keith, P. K, Klimek, L, Koffi N'Goran, B, Kolek, V, Koppelman, G. H, Kowalski, M. L, Kull, I, Kuna, P, Kvedariene, V, Lambrecht, B, Lau, S, Larenas Linnemann, D, Laune, D, Le, L. T. T, Lieberman, P, Lipworth, B, Li, J, Lodrup Carlsen, K, Louis, R, Macnee, W, Magard, Y, Magnan, A, Mahboub, B, Mair, A, Majer, I, Makela, M. J, Manning, P, Mara, S, Marshall, G. D, Masjedi, M. R, Matignon, P, Maurer, M, Mavale Manuel, S, Melén, E, Melo Gomes, E, Meltzer, E. O, Menzies Gow, A, Merk, H, Michel, J. P, Miculinic, N, Mihaltan, F, Milenkovic, B, Mohammad, G. M. Y, Molimard, M, Momas, I, Montilla Santana, A, Morais Almeida, M, Morgan, M, Mösges, R, Mullol, J, Nafti, S, Namazova Baranova, L, Naclerio, R, Neou, A, Neffen, H, Nekam, K, Niggemann, B, Ninot, G, Nyembue, T. D, O'Hehir, R. E, Ohta, K, Okamoto, Y, Okubo, K, Ouedraogo, S, Paggiaro, P, Pali Schöll, I, Panzner, P, Papadopoulos, N, Papi, A, Park, H. S, Passalacqua, G, Pavord, I, Pawankar, R, Pengelly, R, Pfaar, O, Picard, R, Pigearias, B, Pin, I, Plavec, D, Poethig, D, Pohl, W, Popov, T. A, Portejoie, F, Potter, P, Postma, D, Price, D, Rabe, K. F, Raciborski, F, Radier Pontal, F, Repka Ramirez, S, Reitamo, S, Rennard, S, Rodenas, F, Roberts, J, Roca, J, Rodriguez Mañas, L, Rolland, C, Roman Rodriguez, M, Romano, A, Rosado Pinto, J, Rosario, N, Rosenwasser, L, Rottem, M, Ryan, D, Sanchez Borges, M, Scadding, G. K, Schunemann, H. J, Serrano, E, Schmid Grendelmeier, P, Schulz, H, Sheikh, A, Shields, M, Siafakas, N, Sibille, Y, Similowski, T, Simons, F. E. R, Sisul, J. C, Skrindo, I, Smit, H. A, Solé, D, Sooronbaev, T, Spranger, O, Stelmach, R, Sterk, P. J, Sunyer, J, Thijs, C, To, T, Todo Bom, A, Triggiani, M, Valenta, R, Valero, A. L, Valia, E, Valovirta, E, Van Ganse, E, van Hage, M, Vandenplas, O, Vasankari, T, Vellas, B, Vestbo, J, Vezzani, G, Vichyanond, P, Viegi, G, Vogelmeier, C, Vontetsianos, T, Wagenmann, M, Wallaert, B, Walker, S, Wang, D. Y, Wahn, U, Wickman, M, Williams, D. M, Williams, S, Wright, J, Yawn, B. P, Yiallouros, P. K, Yusuf, O. M, Zaidi, A, Zar, H. J, Zernotti, M. E, Zhang, L, Zhong, N, Zidarn, M, Mercier, J., Clinicum, Department of Dermatology, Allergology and Venereology, Department of Medicine, Timo Strandberg / Principal Investigator, Epidemiologie, RS: CAPHRI - R5 - Optimising Patient Care, Department of Paediatrics and Child Health, Faculty of Health Sciences, UCL - SSS/IREC/PNEU - Pôle de Pneumologie, ORL et Dermatologie, UCL - (MGD) Service de pneumologie, Centre Hospitalier Régional Universitaire [Montpellier] (CHRU Montpellier), Laboratoire de Génie Informatique et Ingénierie de Production (LGI2P), IMT - MINES ALES (IMT - MINES ALES), Institut Mines-Télécom [Paris] (IMT)-Institut Mines-Télécom [Paris] (IMT), Bonini, S, Illario, Maddalena, Yiallouros, Panayiotis K. [0000-0002-8339-9285], Custovic, Adnan [0000-0001-5218-7071], Çocuk Sağlığı ve Hastalıkları, Department of Physics, Faculty of Science, and Universidade do Minho

Subjects
Pulmons -- Malalties obstructives, Veterinary medicine, Allergy, Published Erratum, LANGUEDOC-ROUSSILLON, Respiratory Medicine and Allergy, [SDV]Life Sciences [q-bio], Aparell respiratori -- Malalties, OPERATIONAL DEFINITION, Alternative medicine, Review, Chronic respiratory diseases, GLOBAL ALLIANCE, SYSTEMS MEDICINE, 0302 clinical medicine, Medicine and Health Sciences, Immunology and Allergy, MACVIA, 030212 general & internal medicine, AIRWAYS ICP, Lungmedicin och allergi, EIP on AHA, European Innovation Partnership on Active and Healthy Ageing, AIRWAYS ICPs, ARIA, Scaling up, GINA STRATEGY, AIRWAYS, UPDATE ARIA 2008, Respiratory disease, Outras Ciências Agrárias [Ciências Agrárias], 3. Good health, Chronic respiratory disease, ALLERGIC RHINITIS, ICPs, General partnership, Action plan, Erratum, Life Sciences & Biomedicine, Pulmonary and Respiratory Medicine, medicine.medical_specialty, Emerging technologies, Immunology, REFERENCE SITE, Socio-culturale, Predictive medicine, 03 medical and health sciences, Nursing, Critical success factor, Journal Article, medicine, ddc:610, Science & Technology, business.industry, Settore MED/09 - MEDICINA INTERNA, AIRWAYS-ICPS, medicine.disease, Integrated care, Alliance, 030228 respiratory system, Ciências Agrárias::Outras Ciências Agrárias, 3121 General medicine, internal medicine and other clinical medicine, Family medicine, Healthy ageing, business, SEVERE ASTHMA
Abstract

Action Plan B3 of the European Innovation Partnership on Active and Healthy Ageing (EIP on AHA) focuses on the integrated care of chronic diseases. Area 5 (Care Pathways) was initiated using chronic respiratory diseases as a model. The chronic respiratory disease action plan includes (1) AIRWAYS integrated care pathways (ICPs), (2) the joint initiative between the Reference site MACVIA-LR (Contre les MAladies Chroniques pour un VIeillissement Actif) and ARIA (Allergic Rhinitis and its Impact on Asthma), (3) Commitments for Action to the European Innovation Partnership on Active and Healthy Ageing and the AIRWAYS ICPs network. It is deployed in collaboration with the World Health Organization Global Alliance against Chronic Respiratory Diseases (GARD). The European Innovation Partnership on Active and Healthy Ageing has proposed a 5-step framework for developing an individual scaling up strategy: (1) what to scale up: (1-a) databases of good practices, (1-b) assessment of viability of the scaling up of good practices, (1-c) classification of good practices for local replication and (2) how to scale up: (2-a) facilitating partnerships for scaling up, (2-b) implementation of key success factors and lessons learnt, including emerging technologies for individualised and predictive medicine. This strategy has already been applied to the chronic respiratory disease action plan of the European Innovation Partnership on Active and Healthy Ageing. Electronic supplementary material The online version of this article (doi:10.1186/s13601-016-0116-9) contains supplementary material, which is available to authorized users.

Published
2016
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33. Association of season of birth with DNA methylation and allergic disease

Author

Lockett, G. A., Soto-Ramirez, N., Ray, M. A., Everson, T. M., Xu, C-J., Patil, V. K., Terry, W., Kaushal, A., Rezwan, F. I., Ewart, S. L., Gehring, U., Postma, D. S., Koppelman, G. H., Arshad, S. H., Zhang, H., Karmaus, W., Holloway, J. W., LS IRAS EEPI ME (Milieu epidemiologie), Sub Medicinal Chemistry & Chemical biol., dIRAS RA-2, Groningen Research Institute for Asthma and COPD (GRIAC), LS IRAS EEPI ME (Milieu epidemiologie), Sub Medicinal Chemistry & Chemical biol., and dIRAS RA-2

Subjects
Male, 0301 basic medicine, Allergy, 0302 clinical medicine, Pregnancy, Immunology and Allergy, Child, RISK, DNA methylation, Methylation, epigenome-wide association study, 3. Good health, PREVALENCE, Maternal Exposure, Child, Preschool, Prenatal Exposure Delayed Effects, Cohort, INFANCY, Female, Disease Susceptibility, Seasons, 450K array, Cohort study, PACKAGE, Adolescent, Season of birth, DISORDERS, Immunology, Biology, Article, MECHANISMS, 03 medical and health sciences, Hypersensitivity, medicine, Humans, COHORT, Epigenetics, EARLY-CHILDHOOD, POLYMORPHISMS, epigenetics, season of birth, Infant, Newborn, Infant, Reproducibility of Results, Immunoglobulin E, medicine.disease, 030104 developmental biology, 030228 respiratory system, ASTHMA, CpG Islands
Abstract

BackgroundSeason of birth influences allergy risk; however, the biological mechanisms underlying this observation are unclear. The environment affects DNA methylation, with potentially long-lasting effects on gene expression and disease. This study examined whether DNA methylation could underlie the association between season of birth and allergy.MethodsIn a subset of 18-year-old participants from the Isle of Wight (IoW) birth cohort (n = 367), the risks of birth season on allergic outcomes were estimated. Whole blood epigenome-wide DNA methylation was measured, and season-associated CpGs detected using a training-and-testing-based technique. Validation method examined the 8-year-old Prevention and Incidence of Asthma and Mite Allergy (PIAMA) cohort. The relationships between DNA methylation, season of birth and allergy were examined. CpGs were analysed in IoW third-generation cohort newborns.ResultsAutumn birth increased risk of eczema, relative to spring birth. Methylation at 92 CpGs showed association with season of birth in the epigenome-wide association study. In validation, significantly more CpGs had the same directionality than expected by chance, and four were statistically significant. Season-associated methylation was enriched among networks relating to development, the cell cycle and apoptosis. Twenty CpGs were nominally associated with allergic outcomes. Two CpGs were marginally on the causal pathway to allergy. Season-associated methylation was largely absent in newborns, suggesting it arises post-natally.ConclusionsThis study demonstrates that DNA methylation in adulthood is associated with season of birth, supporting the hypothesis that DNA methylation could mechanistically underlie the effect of season of birth on allergy, although other mechanisms are also likely to be involved.

Published
2016
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34. PEF versus FEV1

Author

POSTMA, D S, VAN DER MARK, TH W, and THIADENS, H A

Published
2000

35. Inhaled fluticasone

Author

WEERSINK, E J M, MEIJER, R J, KERSTJENS, H A M, and POSTMA, D S

Published
2000

44. Multi-omics approach to assess genetic susceptibility of COPD in never-smokers

Author

van der Plaat, D. A., Vonk, J. M., Lahousse, L., de Jong, K., Faiz, A., Nedeljkovic, I., Amin, N., van Diemen, C. C., Brusselle, G. G., Bosse, Y., Brandsma, C., Hao, K., Pare, P. D., van Duijn, C. M., Postma, D. S., Boezen, H., Groningen Research Institute for Asthma and COPD (GRIAC), and Life Course Epidemiology (LCE)

Published
2018

49. Overweight patterns throughout childhood and cardiometabolic markers in early adolescence

Author

Berentzen, N E, van Rossem, L, Gehring, U, Koppelman, G H, Postma, D S, de Jongste, J C, Smit, H.A., Wijga, A H, LS IRAS EEPI ME (Milieu epidemiologie), dIRAS RA-2, Groningen Research Institute for Asthma and COPD (GRIAC), LS IRAS EEPI ME (Milieu epidemiologie), dIRAS RA-2, and Pediatrics

Subjects
Male, Pediatric Obesity, Pediatrics, Endocrinology, Diabetes and Metabolism, Medicine (miscellaneous), Blood Pressure, DEVELOPMENTAL TRAJECTORIES, CHILDREN, 030204 cardiovascular system & hematology, Overweight, Weight Gain, Body Mass Index, chemistry.chemical_compound, Endocrinology, 0302 clinical medicine, Risk Factors, OFFSPRING OBESITY, Medicine, Prospective Studies, 030212 general & internal medicine, Age of Onset, Child, Non-U.S. Gov't, Prospective cohort study, Netherlands, Metabolic Syndrome, RISK, Nutrition and Dietetics, BIRTH COHORT, Metabolic Syndrome X, Research Support, Non-U.S. Gov't, Diabetes and Metabolism, Cholesterol, Cardiovascular Diseases, CARDIOVASCULAR-DISEASE, Child, Preschool, INFANCY, GROWTH, Female, NUTRITION, medicine.symptom, Lipoproteins, HDL, Type 2, medicine.medical_specialty, HDL, Lipoproteins, Research Support, Risk Assessment, 03 medical and health sciences, Predictive Value of Tests, Diabetes Mellitus, Journal Article, Humans, Preschool, Triglycerides, business.industry, Cholesterol, HDL, Infant, medicine.disease, Obesity, BODY-MASS INDEX, Blood pressure, Diabetes Mellitus, Type 2, chemistry, Glycated hemoglobin, Age of onset, business, Body mass index, Weight gain, Biomarkers, Follow-Up Studies
Abstract

BACKGROUND: Risk of cardiovascular and metabolic disease is higher in adults who were relatively thin at birth and had subsequent accelerated weight gain. This specific pattern of weight gain may relate to unfavorable cardiometabolic markers already in childhood. We prospectively assessed whether children with different patterns of overweight development from age 3 months to 11 years had distinct levels of cardiometabolic markers at age 12 years.SUBJECTS/METHODS: We used data of 1500 children participating in the PIAMA birth cohort that started in 1996/1997. Parents reported height and weight during 10 waves of follow-up from age 3 months to 11 years. Four distinct overweight development patterns were derived using longitudinal latent class analysis; 'never'; 'early transient'; 'gradually developing' and 'persistent' overweight. Cardiometabolic markers (total-to-high-density lipoprotein cholesterol (TC/HDLC) ratio, blood pressure (BP), glycated hemoglobin (HbA1c)) were assessed at age 12 years in 1500 children.RESULTS: Children who developed overweight gradually and children with persistent overweight throughout childhood, at age 12 years had a 2-3-fold higher risk of having high (490th centile) TC/HDLC ratio, systolic and diastolic BP, compared with children who were never overweight. In children who gradually developed overweight, TC/HDLC ratio was 0.75 higher (95% confidence interval (CI) 0.54-0.96); systolic BP 4.90 mmHg higher (95% CI 2.45-7.36) and diastolic BP 1.78 mmHg higher (95% CI 0.07-3.49) than in children who never had overweight. Estimates for children with persistent overweight were similar.CONCLUSIONS: Children with gradually developing overweight, and those with persistent overweight had unfavorable cholesterol and blood pressure levels already at age 12 years, whereas children with early transient overweight avoided these unfavorable outcomes. Our results support the hypothesis that specific overweight patterns predispose to an adverse cardiometabolic profile, which is already apparent in early adolescence before progressing to adult cardiometabolic disease.

Published
2015
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