Search

Background and Objectives: Papillary thyroid carcinoma (PTC) is one of the most common malignancies of the endocrine system. In order to improve the ability to predict tumor behavior, several studies have been conducted to search for surrogate prognostic immunohistochemical tumor markers. Objective: To evaluate the correlation between the intensity of different immunohistochemical marker staining in PTC and the risk for extrathyroidal extension and metastases. Materials and Methods: The study comprised patients who underwent hemi- or total thyroidectomy. Thyroid tissues were immunohistochemically stained for different tumor proliferative markers: Minichromosome maintenance proteins 2 (MCM2), Ki-67 labeling index, E-Cadherin, Neuropilin-1 and Metallothionein. The correlation between the intensity of each marker staining and the final diagnosis (benign neoplasm and PTC) and the correlation between the intensity of each staining and tumor extrathyroidal extension and metastases were evaluated. Results: The study included 66 patients. Staining for Metallothionein, E-Cadherin and MCM2 significantly differed between benign neoplasm (n = 22) and thyroid-confined PTC (n = 21) (p = 0.002, 0.004 and 0.005, respectively), between benign neoplasm and PTC with extrathyroidal extension (n = 11) (p = 0.001, 0.006 and 0.01, respectively), and between benign neoplasm and PTC with metastases (n = 12) (p = 0.01, p = 0.028 and 0.021, respectively). Conclusions: Immunohistochemical staining for Metallothionein, E-Cadherin and MCM2 significantly distinguished between benign thyroid tumor and PTC. E-Cadherin staining significantly and inversely correlated with the presence of metastases.

Tekst jest komentarzem do projektu podstaw programowych nauczania etyki, opublikowanego przez MEN w 2016 roku w związku z reformą szkolnictwa. Autorzy zwracają uwagę na mankamenty projektu: zawężanie przedmiotu etyki do wyuczonych norm zachowania, nadmierny nacisk położony na przyswajanie wiedzy pojęciowej, brak miejsca na praktyczne rozwijanie zdolności refleksji poprzez dyskusje i sytuacje problemowe. Wskazują na niedostosowanie programu do psychoemocjonalnego poziomu rozwoju uczniów na tym etapie kształcenia, a także brak spójności między poszczególnymi punktami projektu.

Jacques Rancière (2007) w odpowiedzi na pytanie „czy (...) możliwa jest jeszcze praktyka artystyczna krytykująca i podważająca stawanie się sztuki towarem?” zaznacza, że pytanie o to, czy można uciec od rynku „to jedno z tych pytań, których główną zaletą jest przyjemność ze stwierdzenia, że jest ono nierozwiązywalne (...). Krytycy rynku – podkreśla – chętnie jednak opierają swój autorytet na niekończącym się udowadnianiu, że wszyscy inni są albo naiwni, albo są spekulantami.

Introduction: Hypertension affects approximately 50 % of patients with hypertrophic cardiomyopathy (HCM) but clinical course in adults with co-occurring HCM and hypertension is underexplored. Management may be challenging as routine anti-hypertensive medications may worsen obstructive HCM, the most common HCM phenotype. In this scoping review, we sought to synthesize the available literature related to clinical course and outcomes in adults with both conditions and to highlight knowledge gaps to inform future research directions. Methods: We searched 5 electronic databases (PubMed, CINAHL, Scopus, Embase, Web of Science) to identify peer-reviewed articles, 2011–2023. We followed the Preferred Reporting Items for Systematic Reviews and Meta-Analyses-Scoping Review (PRISMA-ScR) guideline. Results: Eleven articles met eligibility. Adults with both conditions were older and had higher rates of obesity and diabetes than adults with HCM alone. Results related to functional class and arrhythmia were equivocal in cross-sectional studies. Only 1 article investigated changes in medical therapy among adults with both conditions. Hypertension was a predictor of worse functional class, but was not associated with all-cause mortality, heart failure-related mortality, or sudden-death. No data was found that related to common hypertension-related outcomes, including renal disease progression, nor patient-reported outcomes, including quality of life. Conclusions: Our results highlight areas for future research to improve understanding of co-occurring HCM and hypertension. These include a need for tailored approaches to medical management to optimize outcomes, evaluation of symptom burden and quality of life, and investigation of hypertension-related outcomes, like renal disease and ischemic stroke, to inform cardiovascular risk mitigation strategies.

Introduction Hypertension affects 40%–60% of adults with hypertrophic cardiomyopathy (HCM), the most common inherited cardiac condition. It can be a diagnostic confounder for HCM, contributing to delayed diagnosis. Clinically, treatment of co-occurring hypertension and HCM poses challenges as first-line and second-line antihypertensive medications are often contraindicated in HCM. The clinical course in adults with hypertension and HCM is also not well understood, and studies examining patient outcomes in this population are equivocal. In this paper, we aim to outline the protocol of a scoping review, a type of literature review, to systematically synthesise existing knowledge on adults with co-occurring HCM and hypertension, highlighting knowledge and evidence gaps, and identifying future research directions to optimise outcomes in this population.Methods and analysis This review is guided by Arksey and O’Malley’s conceptual framework on conducting scoping reviews. We will search five electronic databases (PubMed, CINAHL, Scopus, Embase and Web of Science) and reference lists of publications to identify eligible articles focusing on medical therapy, clinical course or outcomes in adults with HCM and hypertension, between 2011 and 2023. Our search strategy and presentation of results will be guided by the Preferred Reporting Items for Systematic Reviews and Meta-Analyses-Scoping Review guideline. First, two independent reviewers will screen articles, by title and abstract, followed by a full-text screen to identify eligible articles. Relevant data will be extracted and synthesised.Ethics and dissemination Ethical approval is not required for this review as it is a secondary data collection of published articles and does not involve human subject participation. We will present results of this review at relevant professional conferences and patient-centred educational events. Results will be published in a peer-reviewed journal.Trial registration number https://osf.io/cy8qb/?view_only=98197f4850584e51807ff9b62533a706.

The interdisciplinary KALOSKAGATHIA project was designed for the School Otherwise Week, the disciplines involved in the project are „Physical Education and Sports”, „Nutrition and Health” and „Universal Literature”. The main goal of this project was to provide students a image about an important part of the culture and civilization of the world, the culture and civilization of ancient Greece, the birth of the ancient Olympic spirit of competition in all areas but particularly in sports, literature and the art of the time. The educational objectives of the project were to highlight the achievements of the human spirit from that time, training students in respect of important values, to discover prosperous civilizations, to share information about the concept KALOSKAGATHIA and to awaken the interest, engagement and creativity of the students for this project as an extension of the school syllabus content which unfortunately is not Universal Literature at the level of Technical Colleges, the Physical Training is just another one class per week and the breaches in the nourishment of young people during this period are extremely dangerous. Here are just a few reasons why, we, the teachers involved in this project consider it useful, we intend to continue it in the following years, mentioning the fact that we will do a world tour, next year being among the ancient Rome with his dicton „Mens sana in corpore sano”.