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2. Effects of increased levels of supplemental vitamins during the summer in a commercial artificial insemination boar stud

Author

D.W. Lugar, K.E. Harlow, J. Hundley, M. Goncalves, J. Bergstrom, and K.R. Stewart

Subjects
swine, heat stress, seasonality, semen production, vitamins, Animal culture, SF1-1100
Abstract

Heat stress due to increasing extremes in ambient temperature and humidity results in reduced semen quality in boars. This has caused reduced efficiency of the swine industry, requiring more boars to breed the same number of sows. Vitamins such as vitamin C (VC) and E (VE) have been shown to improve semen quality in boars. Recently, vitamin D has been shown to improve semen quality in boars. The purpose of this experiment was to evaluate the effects of increased supplemental vitamins on boar reproduction during the summer season in a commercial boar stud. One hundred and sixty Pig Improvement Company (PIC) terminal line boars (n = 32 per treatment) and 39 maternal, heat-sensitive boars (n = 7 or 8 per treatment) were randomly allocated to treatment and fed a corn and soybean meal-based diet adjusted based on individual boar body condition score. A control (CNT) diet was used that met PIC recommendations for boars. Increased supplementation of specific vitamins was given in the form of a top-dress and consisted of CNT wheat middlings, CNT plus VC (560 mg/day), CNT plus 25-hydroxy vitamin D3 (VD) (125 µg/day), CNT plus VE (275 mg/day) and CNT plus VC, VD and VE (CDE). The experiment was split into three periods based on maximum daily high temperatures in the barn, where period 1 was weeks 1 to 4, period 2 was weeks 5 to 11 and period 3 was weeks 12 to 14. Semen was collected from boars as needed using the stud’s normal production schedule and was analyzed for sperm quantity and quality characteristics. There were no dietary effects on semen volume, sperm concentration or total sperm production (P ≥ 0.553). Total motility of sperm was not impacted by diet (P = 0.115); although, VC tended (P = 0.064) to have a greater progressive motility than CDE. Percentages of morphologically normal sperm and normal acrosomes were not affected by dietary supplementation (P ≥ 0.157). Period effects were observed for most semen quality parameters, with quality generally becoming reduced over time. The present study demonstrates that increased supplementation of vitamins beyond PIC recommendations was not beneficial for boar reproduction during the summer.

Published
2019
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3. Brain function and clinical characterization in the Boston adolescent neuroimaging of depression and anxiety study

Author

N.A. Hubbard, V. Siless, I.R. Frosch, M. Goncalves, N. Lo, J. Wang, C.C.C. Bauer, K. Conroy, E. Cosby, A. Hay, R. Jones, M. Pinaire, F. Vaz De Souza, G. Vergara, S. Ghosh, A. Henin, D.R. Hirshfeld-Becker, S.G. Hofmann, I.M. Rosso, R.P. Auerbach, D.A. Pizzagalli, A. Yendiki, J.D.E. Gabrieli, and S. Whitfield-Gabrieli

Subjects
Computer applications to medicine. Medical informatics, R858-859.7, Neurology. Diseases of the nervous system, RC346-429
Abstract

We present a Human Connectome Project study tailored toward adolescent anxiety and depression. This study is one of the first studies of the Connectomes Related to Human Diseases initiative and is collecting structural, functional, and diffusion-weighted brain imaging data from up to 225 adolescents (ages 14–17 years), 150 of whom are expected to have a current diagnosis of an anxiety and/or depressive disorder. Comprehensive clinical and neuropsychological evaluations and longitudinal clinical data are also being collected. This article provides an overview of task functional magnetic resonance imaging (fMRI) protocols and preliminary findings (N = 140), as well as clinical and neuropsychological characterization of adolescents. Data collection is ongoing for an additional 85 adolescents, most of whom are expected to have a diagnosis of an anxiety and/or depressive disorder. Data from the first 140 adolescents are projected for public release through the National Institutes of Health Data Archive (NDA) with the timing of this manuscript. All other data will be made publicly-available through the NDA at regularly scheduled intervals. This article is intended to serve as an introduction to this project as well as a reference for those seeking to clinical, neurocognitive, and task fMRI data from this public resource.

Published
2020
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4. Variations of the Physical and Chemical Characteristics of Sanitary Landfill Leachate after Percolation into Tropical Soils

Author

M. Goncalves Miguel, L. Belinassi, L.M. Domingues, E.A.A. Nour, and S.Y. Pereira

Subjects
Chemical engineering, TP155-156, Computer engineering. Computer hardware, TK7885-7895
Abstract

Tropical soils are common in Brazil and present very peculiar geotechnical properties, such as fine particle aggregation; natural cementation; and high porosity, which often turn away from the classical models of the Soil Mechanics. Due to this, they are now the focus of recent studies for use as alternative materials for several applications in geotechnical site. This research studies two tropical soils from the Southeastern Brazil to evaluate the variations of the physical and chemical characteristics of sanitary landfill leachate after percolation into these soils. Soil samples were submitted to geotechnical, physical, chemical and mineralogical tests. After these tests, soil samples were compacted with 3 % above their optimum moisture content and placed in polyvinyl chloride columns. The leachate was collected from a regional sanitary landfill and characterized by physical and chemical tests with relation to volatile fatty acid (VFA), chemical oxygen demand (COD), pH, alkalinity, and metals (Cr, Mn, Fe, Co, Ni, Cu, Zn and Pb), before and after percolation into the soils by means of column tests. Curves of concentration versus percolation time for COD, VFA, and metals were obtained for the two soils. COD concentration increased with percolation time for the two soils, while the adsorption/desorption behaviours were different for the two soil, mainly for VFA, Pb, Ni and Co.

Published
2012
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5. Olive Mill Wastewater Anaerobically Digested: Phenolic Compounds with Antiradical Activity

Author

F. La Cara, E. Ionata, G. Del Monaco, L. Marcolongo, M. Goncalves, and I. Paula Marques

Subjects
Chemical engineering, TP155-156, Computer engineering. Computer hardware, TK7885-7895
Abstract

The recovery of phenolic compounds, present in the olive fruits and its by-products, has been intensively studied by the antioxidant properties. Olive mill wastewater (OMW) is a phenolic-rich industrial effluent that can be advantageously valorized by the anaerobic digestion to the methane and agricultural fertilizer productions. The objective of this work was to evaluate the antiradical activity of OMW after anaerobic digestion in order to maximize the valorization of this type of effluents. The digested flow was obtained from an anaerobic hybrid reactor treating OMW at different organic loading rates (OLR), from 3.3 to 7.1 kg COD m3 d-1. OLR rise was applied by increasing progressively the OMW volume fraction from 8 % to 83 % in the feed mixture. The input and output streams, obtained at different OMW volume fractions, were characterized in terms of antiradical activity and phenolic compounds identification and quantification. Despite of the fraction decrease on total phenolic compounds provided by OMW anaerobic digestion, the antiradical activity is still significantly high (EC50 = 3.24) in the digested effluent. Oleuropein was the main phenolic compound present in the substrate before and after anaerobic digestion (about 15 % of the initial value). Others phenolic compounds present are: gallic acid, hydroxytyrosol, tyrosol, and quercetin. These data confirmed that, after the OMW anaerobic treatment to produce biomethane, the remaining flow yet contain useful compounds with antiradical activity.

Published
2012
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7. Mg/Si mineralogical ratio of low-mass planet hosts. Correction for the NLTE effects

Author

Adibekyan, V., da Silva, H. M. Goncalves, Santos, S. G. Sousa N. C., Mena, E. Delgado, and Hakobyan, A. A.

Subjects
Astrophysics - Earth and Planetary Astrophysics, Astrophysics - Solar and Stellar Astrophysics
Abstract

Mg/Si and Fe/Si ratios are important parameters that control the composition of rocky planets. In this work we applied non-LTE correction to the Mg and Si abundances of stars with and without planets to confirm/infirm our previous findings that [Mg/Si] atmospheric abundance is systematically higher for Super-Earth/Neptune-mass planet hosts than stars without planets. Our results show that the small differences of stellar parameters observed in these two groups of stars are not responsible for the already reported difference in the [Mg/Si] ratio. Thus, the high [Mg/Si] ratio of Neptunian hosts is probably related to the formation efficiency of these planets in such environments., Comment: In press. Astrophysics, Vol. 60, No. 3, September , 2017

Published
2017
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10. Trigger and Aperture of the Surface Detector Array of the Pierre Auger Observatory

Author

Abraham, J., Abreu, P., Aglietta, M., Aguirre, C., Ahn, E. J., Allard, D., Allekotte, I., Allen, J., Alvarez-Muñiz, J., Ambrosio, M., Anchordoqui, L., Andringa, S., Anzalone, A., Aramo, C., Arganda, E., Argirò, S., Arisaka, K., Arneodo, F., Arqueros, F., Asch, T., Asorey, H., Assis, P., Aublin, J., Ave, M., Avila, G., Bäcker, T., Badagnani, D., Barber, K. B., Barbosa, A. F., Barroso, S. L. C., Baughman, B., Bauleo, P., Beatty, J. J., Beau, T., Becker, B. R., Becker, K. H., Bellétoile, A., Bellido, J. A., BenZvi, S., Berat, C., Bernardini, P., Bertou, X., Biermann, P. L., Billoir, P., Blanch-Bigas, O., Blanco, F., Bleve, C., Blümer, H., Boháčová, M., Boncioli, D., Bonifazi, C., Bonino, R., Borodai, N., Brack, J., Brogueira, P., Brown, W. C., Bruijn, R., Buchholz, P., Bueno, A., Burton, R. E., Busca, N. G., Caballero-Mora, K. S., Caramete, L., Caruso, R., Carvalho, W., Castellina, A., Catalano, O., Cazon, L., Cester, R., Chauvin, J., Chiavassa, A., Chinellato, J. A., Chou, A., Chudoba, J., Chye, J., Clay, R. W., Colombo, E., Conceição, R., Connolly, B., Contreras, F., Coppens, J., Cordier, A., Cotti, U., Coutu, S., Covault, C. E., Creusot, A., Criss, A., Cronin, J., Curutiu, A., Dagoret-Campagne, S., Dallier, R., Daumiller, K., Dawson, B. R., de Almeida, R. M., De Domenico, M., De Donato, C., de Jong, S. J., De La Vega, G., Junior, W. J. M. de Mello, Neto, J. R. T. de Mello, De Mitri, I., de Souza, V., de Vries, K. D., Decerprit, G., del Peral, L., Deligny, O., Della Selva, A., Fratte, C. Delle, Dembinski, H., Di Giulio, C., Diaz, J. C., Diep, P. N., Dobrigkeit, C., D'Olivo, J. C., Dong, P. N., Dorofeev, A., Anjos, J. C. dos, Dova, M. T., D'Urso, D., Dutan, I., DuVernois, M. A., Engel, R., Erdmann, M., Escobar, C. O., Etchegoyen, A., Luis, P. Facal San, Falcke, H., Farrar, G., Fauth, A. C., Fazzini, N., Ferrer, F., Ferrero, A., Fick, B., Filevich, A., Filipčič, A., Fleck, I., Fliescher, S., Fracchiolla, C. E., Fraenkel, E. D., Fulgione, W., Gamarra, R. F., Gambetta, S., García, B., Gámez, D. García, Garcia-Pinto, D., Garrido, X., Gelmini, G., Gemmeke, H., Ghia, P. L., Giaccari, U., Giller, M., Glass, H., Goggin, L. M., Gold, M. S., Golup, G., Albarracin, F. Gomez, Berisso, M. Gómez, Gonçalves, P., Amaral, M. Gonçalves do, Gonzalez, D., Gonzalez, J. G., Góra, D., Gorgi, A., Gouffon, P., Gozzini, S. R., Grashorn, E., Grebe, S., Grigat, M., Grillo, A. F., Guardincerri, Y., Guarino, F., Guedes, G. P., Gutiérrez, J., Hague, J. D., Halenka, V., Hansen, P., Harari, D., Harmsma, S., Harton, J. L., Haungs, A., Healy, M. D., Hebbeker, T., Hebrero, G., Heck, D., Hojvat, C., Holmes, V. C., Homola, P., Hörandel, J. R., Horneffer, A., Hrabovský, M., Huege, T., Hussain, M., Iarlori, M., Insolia, A., Ionita, F., Italiano, A., Jiraskova, S., Kaducak, M., Kampert, K. H., Karova, T., Kasper, P., Kégl, B., Keilhauer, B., Kemp, E., Kieckhafer, R. M., Klages, H. O., Kleifges, M., Kleinfeller, J., Knapik, R., Knapp, J., Koang, D. -H., Krieger, A., Krömer, O., Kruppke-Hansen, D., Kuehn, F., Kuempel, D., Kulbartz, K., Kunka, N., Kusenko, A., La Rosa, G., Lachaud, C., Lago, B. L., Lautridou, P., Leão, M. S. A. B., Lebrun, D., Lebrun, P., Lee, J., de Oliveira, M. A. Leigui, Lemiere, A., Letessier-Selvon, A., Leuthold, M., Lhenry-Yvon, I., López, R., Agüera, A. Lopez, Louedec, K., Bahilo, J. Lozano, Lucero, A., Lyberis, H., Maccarone, M. C., Macolino, C., Maldera, S., Mandat, D., Mantsch, P., Mariazzi, A. G., Maris, I. C., Falcon, H. R. Marquez, Martello, D., Bravo, O. Martínez, Mathes, H. J., Matthews, J., Matthews, J. A. J., Matthiae, G., Maurizio, D., Mazur, P. O., McEwen, M., McNeil, R. R., Medina-Tanco, G., Melissas, M., Melo, D., Menichetti, E., Menshikov, A., Meyhandan, R., Micheletti, M. I., Miele, G., Miller, W., Miramonti, L., Mollerach, S., Monasor, M., Ragaigne, D. Monnier, Montanet, F., Morales, B., Morello, C., Moreno, J. C., Morris, C., Mostafá, M., Moura, C. A., Mueller, S., Muller, M. A., Mussa, R., Navarra, G., Navarro, J. L., Navas, S., Necesal, P., Nellen, L., Newman-Holmes, C., Newton, D., Nhung, P. T., Nierstenhoefer, N., Nitz, D., Nosek, D., Nožka, L., Nyklicek, M., Oehlschläger, J., Olinto, A., Oliva, P., Olmos-Gilbaja, V. M., Ortiz, M., Pacheco, N., Selmi-Dei, D. Pakk, Palatka, M., Pallotta, J., Parente, G., Parizot, E., Parlati, S., Pastor, S., Patel, M., Paul, T., Pavlidou, V., Payet, K., Pech, M., Pȩkala, J., Pepe, I. M., Perrone, L., Pesce, R., Petermann, E., Petrera, S., Petrinca, P., Petrolini, A., Petrov, Y., Petrovic, J., Pfendner, C., Piegaia, R., Pierog, T., Pimenta, M., Pinto, T., Pirronello, V., Pisanti, O., Platino, M., Pochon, J., Ponce, V. H., Pontz, M., Privitera, P., Prouza, M., Quel, E. J., Rautenberg, J., Ravel, O., Ravignani, D., Redondo, A., Revenu, B., Rezende, F. A. S., Ridky, J., Riggi, S., Risse, M., Rivière, C., Rizi, V., Robledo, C., Rodriguez, G., Martino, J. Rodriguez, Rojo, J. Rodriguez, Rodriguez-Cabo, I., Rodríguez-Frías, M. D., Ros, G., Rosado, J., Rossler, T., Roth, M., Rouillé-d'Orfeuil, B., Roulet, E., Rovero, A. C., Salamida, F., Salazar, H., Salina, G., Sánchez, F., Santander, M., Santo, C. E., Santos, E. M., Sarazin, F., Sarkar, S., Sato, R., Scharf, N., Scherini, V., Schieler, H., Schiffer, P., Schmidt, A., Schmidt, F., Schmidt, T., Scholten, O., Schoorlemmer, H., Schovancova, J., Schovánek, P., Schroeder, F., Schulte, S., Schüssler, F., Schuster, D., Sciutto, S. J., Scuderi, M., Segreto, A., Semikoz, D., Settimo, M., Shellard, R. C., Sidelnik, I., Siffert, B. B., Sigl, G., Śmiałkowski, A., Šmída, R., Smith, B. E., Snow, G. R., Sommers, P., Sorokin, J., Spinka, H., Squartini, R., Strazzeri, E., Stutz, A., Suarez, F., Suomijärvi, T., Supanitsky, A. D., Sutherland, M. S., Swain, J., Szadkowski, Z., Tamashiro, A., Tamburro, A., Tarutina, T., Taşcău, O., Tcaciuc, R., Tcherniakhovski, D., Tegolo, D., Thao, N. T., Thomas, D., Ticona, R., Tiffenberg, J., Timmermans, C., Tkaczyk, W., Peixoto, C. J. Todero, Tomé, B., Tonachini, A., Torres, I., Travnicek, P., Tridapalli, D. B., Tristram, G., Trovato, E., Tueros, M., Ulrich, R., Unger, M., Urban, M., Galicia, J. F. Valdés, Valiño, I., Valore, L., Berg, A. M. van den, Vázquez, J. R., Vázquez, R. A., Veberič, D., Velarde, A., Venters, T., Verzi, V., Videla, M., Villaseñor, L., Vorobiov, S., Voyvodic, L., Wahlberg, H., Wahrlich, P., Wainberg, O., Warner, D., Watson, A. A., Westerhoff, S., Whelan, B. J., Wieczorek, G., Wiencke, L., Wilczyńska, B., Wilczyński, H., Wileman, C., Winnick, M. G., Wu, H., Wundheiler, B., Yamamoto, T., Younk, P., Yuan, G., Yushkov, A., Zas, E., Zavrtanik, D., Zavrtanik, M., Zaw, I., Zepeda, A., and Ziolkowski, M.

Subjects
Astrophysics - Instrumentation and Methods for Astrophysics
Abstract

The surface detector array of the Pierre Auger Observatory consists of 1600 water-Cherenkov detectors, for the study of extensive air showers (EAS) generated by ultra-high-energy cosmic rays. We describe the trigger hierarchy, from the identification of candidate showers at the level of a single detector, amongst a large background (mainly random single cosmic ray muons), up to the selection of real events and the rejection of random coincidences. Such trigger makes the surface detector array fully efficient for the detection of EAS with energy above $3\times 10^{18}$ eV, for all zenith angles between 0$^\circ$ and 60$^\circ$, independently of the position of the impact point and of the mass of the primary particle. In these range of energies and angles, the exposure of the surface array can be determined purely on the basis of the geometrical acceptance., Comment: 29 pages, 12 figures

Published
2011
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11. The Fluorescence Detector of the Pierre Auger Observatory

Author

The Pierre Auger Collaboration, Abraham, J., Abreu, P., Aglietta, M., Aguirre, C., Ahn, E. J., Allard, D., Allekotte, I., Allen, J., Allison, P., Alvarez-Muñiz, J., Ambrosio, M., Anchordoqui, L., Andringa, S., Anzalone, A., Aramo, C., Arganda, E., Argirò, S., Arisaka, K., Arneodo, F., Arqueros, F., Asch, T., Asorey, H., Assis, P., Aublin, J., Ave, M., Avila, G., Bacher, A., Bäcker, T., Badagnani, D., Barber, K. B., Barbosa, A. F., Barbosa, H. J. M., Barenthien, N., Barroso, S. L. C., Baughman, B., Bauleo, P., Beatty, J. J., Beau, T., Becker, B. R., Becker, K. H., Bellétoile, A., Bellido, J. A., BenZvi, S., Berat, C., Bernardini, P., Bertou, X., Biermann, P. L., Billoir, P., Blanch-Bigas, O., Blanco, F., Bleve, C., Blümer, H., Boháčová, M., Bollmann, E., Bolz, H., Bonifazi, C., Bonino, R., Borodai, N., Bracci, F., Brack, J., Brogueira, P., Brown, W. C., Bruijn, R., Buchholz, P., Bueno, A., Burton, R. E., Busca, N. G., Caballero-Mora, K. S., Caramete, D. CaminL., Caruso, R., Carvalho, W., Castellina, A., Castro, J., Catalano, O., Cazon, L., Cester, R., Chauvin, J., Chiavassa, A., Chinellato, J. A., Chou, A., Chudoba, J., Chye, J., Clark, P. D. J., Clay, R. W., Colombo, E., Conceição, R., Connolly, B., Contreras, F., Coppens, J., Cordero, A., Cordier, A., Cotti, U., Coutu, S., Covault, C. E., Creusot, A., Criss, A., Cronin, J. W., Cuautle, J., Curutiu, A., Dagoret-Campagne, S., Dallier, R., Daudo, F., Daumiller, K., Dawson, B. R., de Almeida, R. M., De Domenico, M., De Donato, C., de Jong, S. J., De La Vega, G., Junior, W. J. M. de Mello, Neto, J. R. T. de Mello, De Mitri, I., de Souza, V., de Vries, K. D., Decerprit, G., del Peral, L., Deligny, O., Della Selva, A., Fratte, C. Delle, Dembinski, H., Di Giulio, C., Diaz, J. C., Diep, P. N., Dobrigkeit, C., D'Olivo, J. C., Dong, P. N., Dornic, D., Dorofeev, A., Anjos, J. C. dos, Dova, M. T., D'Urso, D., Dutan, I., DuVernois, M. A., Engel, R., Erdmann, M., Escobar, C. O., Etchegoyen, A., Luis, P. Facal San, Falcke, H., Farrar, G., Fauth, A. C., Fazzini, N., Ferrer, F., Ferrero, A., Fick, B., Filevich, A., Filipčič, A., Fleck, I., Fliescher, S., Fonte, R., Fracchiolla, C. E., Fraenkel, E. D., Fulgione, W., Gamarra, R. F., Gambetta, S., García, B., Gámez, D. García, Garcia-Pinto, D., Garrido, X., Geenen, H., Gelmini, G., Gemmeke, H., Ghia, P. L., Giaccari, U., Gibbs, K., Giller, M., Gitto, J., Glass, H., Goggin, L. M., Gold, M. S., Golup, G., Albarracin, F. Gomez, Berisso, M. Gómez, Vitale, P. F. Gomez, Gonçalves, P., Amaral, M. Gonçalves do, Gonzalez, D., Gonzalez, J. G., Góra, D., Gorgi, A., Gouffon, P., Grashorn, E., Grassi, V., Grebe, S., Grigat, M., Grillo, A. F., Grygar, J., Guardincerri, Y., Guardone, N., Guerard, C., Guarino, F., Gumbsheimer, R., Guedes, G. P., Gutiérrez, J., Hague, J. D., Halenka, V., Hansen, P., Harari, D., Harmsma, S., Hartmann, S., Harton, J. L., Haungs, A., Healy, M. D., Hebbeker, T., Hebrero, G., Heck, D., Hojvat, C., Holmes, V. C., Homola, P., Hofman, G., Hörandel, J. R., Horneffer, A., Horvat, M., Hrabovský, M., Hucker, H., Huege, T., Hussain, M., Iarlori, M., Insolia, A., Ionita, F., Italiano, A., Jiraskova, S., Kaducak, M., Kampert, K. H., Karova, T., Kasper, P., Kégl, B., Keilhauer, B., Kemp, E., Kern, H., Kieckhafer, R. M., Klages, H. O., Kleifges, M., Kleinfeller, J., Knapik, R., Knapp, J., Koang, D. -H., Kopmann, A., Krieger, A., Krömer, O., Kruppke-Hansen, D., Kuempel, D., Kunka, N., Kusenko, A., La Rosa, G., Lachaud, C., Lago, B. L., Lautridou, P., Leão, M. S. A. B., Lebrun, D., Lebrun, P., Lee, J., de Oliveira, M. A. Leigui, Lemiere, A., Letessier-Selvon, A., Leuthold, M., Lhenry-Yvon, I., López, R., Agüera, A. Lopez, Louedec, K., Bahilo, J. Lozano, Lucero, A., Lyberis, H., Maccarone, M. C., Macolino, C., Maldera, S., Malek, M., Mandat, D., Mantsch, P., Marchetto, F., Mariazzi, A. G., Maris, I. C., Falcon, H. R. Marquez, Martello, D., Martineau, O., Bravo, O. Martínez, Mathes, H. J., Matthews, J., Matthews, J. A. J., Matthiae, G., Maurizio, D., Mazur, P. O., McEwen, M., McNeil, R. R., Medina-Tanco, G., Melissas, M., Melo, D., Menichetti, E., Menshikov, A., Meyhandan, R., Micheletti, M. I., Miele, G., Miller, W., Miramonti, L., Mollerach, S., Monasor, M., Ragaigne, D. Monnier, Montanet, F., Morales, B., Morello, C., Moreno, J. C., Morris, C., Mostafá, M., Moura, C. A., Mucchi, M., Mueller, S., Muller, M. A., Mussa, R., Navarra, G., Navarro, J. L., Navas, S., Necesal, P., Nellen, L., Nerling, F., Newman-Holmes, C., Newton, D., Nhung, P. T., Nicotra, D., Nierstenhoefer, N., Nitz, D., Nosek, D., Nožka, L., Nyklicek, M., Oehlschläger, J., Olinto, A., Oliva, P., Olmos-Gilbaja, V. M., Ortiz, M., Ortolani, F., Oßwald, B., Pacheco, N., Selmi-Dei, D. Pakk, Palatka, M., Pallotta, J., Parente, G., Parizot, E., Parlati, S., Pastor, S., Patel, M., Paul, T., Pavlidou, V., Payet, K., Pech, M., Pȩkala, J., Pepe, I. M., Perrone, L., Pesce, R., Petermann, E., Petrera, S., Petrinca, P., Petrolini, A., Petrov, Y., Petrovic, J., Pfendner, C., Pichel, A., Piegaia, R., Pierog, T., Pimenta, M., Pinto, T., Pirronello, V., Pisanti, O., Platino, M., Pochon, J., Ponce, V. H., Pontz, M., Pouryamout, J., Prado Jr., L., Privitera, P., Prouza, M., Quel, E. J., Rautenberg, G. Raia J., Ravel, O., Ravignani, D., Redondo, A., Reis, H. C., Reucroft, S., Revenu, B., Rezende, F. A. S., Ridky, J., Riggi, S., Risse, M., Rivière, C., Rizi, V., Robledo, C., Roberts, M. D., Rodriguez, G., Martino, J. Rodriguez, Rojo, J. Rodriguez, Rodriguez-Cabo, I., Rodríguez-Frías, M. D., Ros, G., Rosado, J., Rossler, T., Roth, M., Rouillé-d'Orfeuil, B., Roulet, E., Rovero, A. C., Salamida, F., b, H. Salazar, Salina, G., Sánchez, F., Santander, M., Santo, C. E., Santos, E. M., Sarazin, F., Sarkar, S., Sato, R., Scharf, N., Scherini, V., Schieler, H., Schiffer, P., Schmidt, G. Schleif A., Schmidt, F., Schmidt, T., Scholten, O., Schoorlemmer, H., Schovancova, J., Schovánek, P., Schroeder, F., Schulte, S., Schüssler, F., Schuster, D., Sciutto, S. J., Scuderi, M., Segreto, A., Semikoz, D., Sequieros, G., Settimo, M., Shellard, R. C., Sidelnik, I., Siffert, B. B., Smiałkowski, A., Šmída, R., Smith, A. G. K., Smith, B. E., Snow, G. R., Sommers, P., Sorokin, J., Spinka, H., Squartini, R., Strazzeri, E., Stutz, A., Suarez, F., Suomijärvi, T., Supanitsky, A. D., Sutherland, M. S., Swain, J., Szadkowski, Z., Tamashiro, A., Tamburro, A., Tarutina, T., Taşcău, O., Tcaciuc, R., Tcherniakhovski, D., Thao, N. T., Thomas, D., Ticona, R., Tiffenberg, J., Timmermans, C., Tkaczyk, W., Peixoto, C. J. Todero, Tomé, B., Tonachini, A., Torres, I., Trapani, P., Travnicek, P., Tridapalli, D. B., Tristram, G., Trovato, E., Tuci, V., Tueros, M., Tusi, E., Ulrich, R., Unger, M., Urban, M., Galicia, J. F. Valdés, Valiño, I., Valore, L., Berg, A. M. van den, Vázquez, J. R., Vázquez, R. A., Veberič, D., Velarde, A., Venters, T., Verzi, V., Videla, M., Villaseñor, L., Vitali, G., Vorobiov, S., Voyvodic, L., Wahlberg, H., Wahrlich, P., Wainberg, O., Warner, D., Westerhoff, S., Whelan, B. J., Wild, N., Wiebusch, C., Wieczorek, G., Wiencke, L., Wilczyńska, B., Wilczyński, H., Wileman, C., Winnick, M. G., Wörner, G., Wu, H., Wundheiler, B., Yamamoto, T., Younk, P., Yuan, G., Yushkov, A., Zas, E., Zavrtanik, D., Zavrtanik, M., Zaw, I., b, A. Zepeda, and Ziolkowski, M.

Subjects
Astrophysics - Instrumentation and Methods for Astrophysics
Abstract

The Pierre Auger Observatory is a hybrid detector for ultra-high energy cosmic rays. It combines a surface array to measure secondary particles at ground level together with a fluorescence detector to measure the development of air showers in the atmosphere above the array. The fluorescence detector comprises 24 large telescopes specialized for measuring the nitrogen fluorescence caused by charged particles of cosmic ray air showers. In this paper we describe the components of the fluorescence detector including its optical system, the design of the camera, the electronics, and the systems for relative and absolute calibration. We also discuss the operation and the monitoring of the detector. Finally, we evaluate the detector performance and precision of shower reconstructions., Comment: 53 pages. Submitted to Nuclear Instruments and Methods in Physics Research Section A

Published
2009
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12. Calibration and Monitoring of the Pierre Auger Observatory

Author

The Pierre Auger Collaboration, Abraham, J., Abreu, P., Aglietta, M., Aguirre, C., Ahn, E. J., Allard, D., Allekotte, I., Allen, J., Alvarez-Muñiz, J., Ambrosio, M., Anchordoqui, L., Andringa, S., Anzalone, A., Aramo, C., Arganda, E., Argirò, S., Arisaka, K., Arneodo, F., Arqueros, F., Asch, T., Asorey, H., Assis, P., Aublin, J., Ave, M., Avila, G., Bäcker, T., Badagnani, D., Barber, K. B., Barbosa, A. F., Barroso, S. L. C., Baughman, B., Bauleo, P., Beatty, J. J., Beau, T., Becker, B. R., Becker, K. H., Bellétoile, A., Bellido, J. A., BenZvi, S., Berat, C., Bernardini, P., Bertou, X., Biermann, P. L., Billoir, P., Blanch-Bigas, O., Blanco, F., Bleve, C., Blümer, H., Boháčová, M., Boncioli, D., Bonifazi, C., Bonino, R., Borodai, N., Brack, J., Brogueira, P., Brown, W. C., Bruijn, R., Buchholz, P., Bueno, A., Burton, R. E., Busca, N. G., Caballero-Mora, K. S., Caramete, L., Caruso, R., Carvalho, W., Castellina, A., Catalano, O., Cazon, L., Cester, R., Chauvin, J., Chiavassa, A., Chinellato, J. A., Chou, A., Chudoba, J., Chye, J., Clay, R. W., Colombo, E., Conceição, R., Connolly, B., Contreras, F., Coppens, J., Cordier, A., Cotti, U., Coutu, S., Covault, C. E., Creusot, A., Criss, A., Cronin, J., Curutiu, A., Dagoret-Campagne, S., Dallier, R., Daumiller, K., Dawson, B. R., de Almeida, R. M., De Domenico, M., De Donato, C., de Jong, S. J., De La Vega, G., Junior, W. J. M. de Mello, Neto, J. R. T. de Mello, De Mitri, I., de Souza, V., de Vries, K. D., Decerprit, G., del Peral, L., Deligny, O., Della Selva, A., Fratte, C. Delle, Dembinski, H., DiGiulio, C., Diaz, J. C., Diep, P. N., Dobrigkeit, C., D'Olivo, J. C., Dong, P. N., Dorofeev, A., Anjos, J. C. dos, Dova, M. T., D'Urso, D., Dutan, I., DuVernois, M. A., Engel, R., Erdmann, M., Escobar, C. O., Etchegoyen, A., Luis, P. Facal San, Falcke, H., Farrar, G., Fauth, A. C., Fazzini, N., Ferrer, F., Ferrero, A., Fick, B., Filevich, A., Filipčič, A., Fleck, I., Fliescher, S., Fracchiolla, C. E., Fraenkel, E. D., Fulgione, W., Gamarra, R. F., Gambetta, S., García, B., GarcíaGámez, D., Garcia-Pinto, D., Garrido, X., Gelmini, G., Gemmeke, H., Ghia, P. L., Giaccari, U., Giller, M., Glass, H., Goggin, L. M., Gold, M. S., Golup, G., Albarracin, F. Gomez, Berisso, M. Gómez, Gonçalves, P., Amaral, M. Gonçalves do, Gonzalez, D., Gonzalez, J. G., Góra, D., Gorgi, A., Gouffon, P., Gozzini, S. R., Grashorn, E., Grebe, S., Grigat, M., Grillo, A. F., Guardincerri, Y., Guarino, F., Guedes, G. P., Gutiérrez, J., Hague, J. D., Halenka, V., Hansen, P., Harari, D., Harmsma, S., Harton, J. L., Haungs, A., Healy, M. D., Hebbeker, T., Hebrero, G., Heck, D., Hojvat, C., Holmes, V. C., Homola, P., Hörandel, J. R., Horneffer, A., Hrabovský, M., Huege, T., Hussain, M., Iarlori, M., Insolia, A., Ionita, F., Italiano, A., Jiraskova, S., Kaducak, M., Kampert, K. H., Karova, T., Kasper, P., Kégl, B., Keilhauer, B., Kemp, E., Kieckhafer, R. M., Klages, H. O., Kleifges, M., Kleinfeller, J., Knapik, R., Knapp, J., Koang, D. -H., Krieger, A., Krömer, O., Kruppke-Hansen, D., Kuehn, F., Kuempel, D., Kulbartz, K., Kunka, N., Kusenko, A., LaRosa, G., Lachaud, C., Lago, B. L., Lautridou, P., Leão, M. S. A. B., Lebrun, D., Lebrun, P., Lee, J., de Oliveira, M. A. Leigui, Lemiere, A., Letessier-Selvon, A., Leuthold, M., Lhenry-Yvon, I., López, R., Agüera, A. Lopez, Louedec, K., Bahilo, J. Lozano, Lucero, A., Lyberis, H., Maccarone, M. C., Macolino, C., Maldera, S., Mandat, D., Mantsch, P., Mariazzi, A. G., Maris, I. C., Falcon, H. R. Marquez, Martello, D., Bravo, O. Martínez, Mathes, H. J., Matthews, J., Matthews, J. A. J., Matthiae, G., Maurizio, D., Mazur, P. O., McEwen, M., McNeil, R. R., Medina-Tanco, G., Melissas, M., Melo, D., Menichetti, E., Menshikov, A., Meyhandan, R., Micheletti, M. I., Miele, G., Miller, W., Miramonti, L., Mollerach, S., Monasor, M., Ragaigne, D. Monnier, Montanet, F., Morales, B., Morello, C., Moreno, J. C., Morris, C., Mostafá, M., Moura, C. A., Mueller, S., Muller, M. A., Mussa, R., Navarra, G., Navarro, J. L., Navas, S., Necesal, P., Nellen, L., Newman-Holmes, C., Newton, D., Nhung, P. T., Nierstenhoefer, N., Nitz, D., Nosek, D., Nožka, L., Nyklicek, M., Oehlschläger, J., Olinto, A., Oliva, P., Olmos-Gilbaja, V. M., Ortiz, M., Pacheco, N., Selmi-Dei, D. Pakk, Palatka, M., Pallotta, J., Parente, G., Parizot, E., Parlati, S., Pastor, S., Patel, M., Paul, T., Pavlidou, V., Payet, K., Pech, M., Pȩkala, J., Pepe, I. M., Perrone, L., Pesce, R., Petermann, E., Petrera, S., Petrinca, P., Petrolini, A., Petrov, Y., Petrovic, J., Pfendner, C., Piegaia, R., Pierog, T., Pimenta, M., Pinto, T., Pirronello, V., Pisanti, O., Platino, M., Pochon, J., Ponce, V. H., Pontz, M., Privitera, P., Prouza, M., Quel, E. J., Rautenberg, J., Ravel, O., Ravignani, D., Redondo, A., Revenu, B., Rezende, F. A. S., Ridky, J., Riggi, S., Risse, M., Rivière, C., Rizi, V., Robledo, C., Rodriguez, G., Martino, J. Rodriguez, Rojo, J. Rodriguez, Rodriguez-Cabo, I., Rodríguez-Frías, M. D., Ros, G., Rosado, J., Rossler, T., Roth, M., Rouillé-d'Orfeuil, B., Roulet, E., Rovero, A. C., Salamida, F., Salazar, H., Salina, G., Sánchez, F., Santander, M., Santo, C. E., Santos, E. M., Sarazin, F., Sarkar, S., Sato, R., Scharf, N., Scherini, V., Schieler, H., Schiffer, P., Schmidt, A., Schmidt, F., Schmidt, T., Scholten, O., Schoorlemmer, H., Schovancova, J., Schovánek, P., Schroeder, F., Schulte, S., Schüssler, F., Schuster, D., Sciutto, S. J., Scuderi, M., Segreto, A., Semikoz, D., Settimo, M., Shellard, R. C., Sidelnik, I., Siffert, B. B., Sigl, G., Śmiałkowski, A., Šmída, R., Smith, B. E., Snow, G. R., Sommers, P., Sorokin, J., Spinka, H., Squartini, R., Strazzeri, E., Stutz, A., Suarez, F., Suomijärvi, T., Supanitsky, A. D., Sutherland, M. S., Swain, J., Szadkowski, Z., Tamashiro, A., Tamburro, A., Tarutina, T., Taşcău, O., Tcaciuc, R., Tcherniakhovski, D., Tegolo, D., Thao, N. T., Thomas, D., Ticona, R., Tiffenberg, J., Timmermans, C., Tkaczyk, W., Peixoto, C. J. Todero, Tomé, B., Tonachini, A., Torres, I., Travnicek, P., Tridapalli, D. B., Tristram, G., Trovato, E., Tueros, M., Ulrich, R., Unger, M., Urban, M., Galicia, J. F. Valdés, Valiño, I., Valore, L., vandenBerg, A. M., Vázquez, J. R., Vázquez, R. A., Veberič, D., Velarde, A., Venters, T., Verzi, V., Videla, M., Villaseñor, L., Vorobiov, S., Voyvodic, L., Wahlberg, H., Wahrlich, P., Wainberg, O., Warner, D., Watson, A. A., Westerhoff, S., Whelan, B. J., Wieczorek, G., Wiencke, L., Wilczyńska, B., Wilczyński, H., Wileman, C., Winnick, M. G., Wu, H., Wundheiler, B., Yamamoto, T., Younk, P., Yuan, G., Yushkov, A., Zas, E., Zavrtanik, D., Zavrtanik, M., Zaw, I., Zepeda, A., and Ziolkowski, M.

Subjects
Astrophysics - Instrumentation and Methods for Astrophysics, Astrophysics - High Energy Astrophysical Phenomena
Abstract

Reports on the atmospheric monitoring, calibration, and other operating systems of the Pierre Auger Observatory. Contributions to the 31st International Cosmic Ray Conference, Lodz, Poland, July 2009., Comment: Contributions to the 31st International Cosmic Ray Conference, Lodz, Poland, July 2009

Published
2009

13. Operations of and Future Plans for the Pierre Auger Observatory

Author

The Pierre Auger Collaboration, Abraham, J., Abreu, P., Aglietta, M., Aguirre, C., Ahn, E. J., Allard, D., Allekotte, I., Allen, J., Alvarez-Muñiz, J., Ambrosio, M., Anchordoqui, L., Andringa, S., Anzalone, A., Aramo, C., Arganda, E., Argirò, S., Arisaka, K., Arneodo, F., Arqueros, F., Asch, T., Asorey, H., Assis, P., Aublin, J., Ave, M., Avila, G., Bäcker, T., Badagnani, D., Barber, K. B., Barbosa, A. F., Barroso, S. L. C., Baughman, B., Bauleo, P., Beatty, J. J., Beau, T., Becker, B. R., Becker, K. H., Bellétoile, A., Bellido, J. A., BenZvi, S., Berat, C., Bernardini, P., Bertou, X., Biermann, P. L., Billoir, P., Blanch-Bigas, O., Blanco, F., Bleve, C., Blümer, H., Boháčová, M., Boncioli, D., Bonifazi, C., Bonino, R., Borodai, N., Brack, J., Brogueira, P., Brown, W. C., Bruijn, R., Buchholz, P., Bueno, A., Burton, R. E., Busca, N. G., Caballero-Mora, K. S., Caramete, L., Caruso, R., Carvalho, W., Castellina, A., Catalano, O., Cazon, L., Cester, R., Chauvin, J., Chiavassa, A., Chinellato, J. A., Chou, A., Chudoba, J., Chye, J., Clay, R. W., Colombo, E., Conceição, R., Connolly, B., Contreras, F., Coppens, J., Cordier, A., Cotti, U., Coutu, S., Covault, C. E., Creusot, A., Criss, A., Cronin, J., Curutiu, A., agoret-Campagne, S., Dallier, R., Daumiller, K., Dawson, B. R., de Almeida, R. M., De Domenico, M., De Donato, C., de Jong, S. J., De La Vega, G., Junior, W. J. M. de Mello, Neto, J. R. T. de Mello, De Mitri, I., de Souza, V., de Vries, K. D., Decerprit, G., del Peral, L., Deligny, O., Della Selva, A., Fratte, C. Delle, Dembinski, H., DiGiulio, C., Diaz, J. C., Diep, P. N., Dobrigkeit, C., D'Olivo, J. C., Dong, P. N., Dorofeev, A., Anjos, J. C. dos, Dova, M. T., D'Urso, D., Dutan, I., DuVernois, M. A., Engel, R., Erdmann, M., Escobar, C. O., Etchegoyen, A., Luis, P. Facal San, Falcke, H., Farrar, G., Fauth, A. C., Fazzini, N., Ferrer, F., Ferrero, A., Fick, B., Filevich, A., Filipčič, A., Fleck, I., Fliescher, S., Fracchiolla, C. E., Fraenkel, E. D., Fulgione, W., Gamarra, R. F., Gambetta, S., García, B., GarcíaGámez, D., Garcia-Pinto, D., Garrido, X., Gelmini, G., Gemmeke, H., Ghia, P. L., Giaccari, U., Giller, M., Glass, H., Goggin, L. M., Gold, M. S., Golup, G., Albarracin, F. Gomez, Berisso, M. Gómez, Gonçalves, P., Amaral, M. Gonçalves do, Gonzalez, D., Gonzalez, J. G., Góra, D., Gorgi, A., Gouffon, P., Gozzini, S. R., Grashorn, E., Grebe, S., Grigat, M., Grillo, A. F., Guardincerri, Y., Guarino, F., Guedes, G. P., Gutiérrez, J., Hague, J. D., Halenka, V., Hansen, P., Harari, D., Harmsma, S., Harton, J. L., Haungs, A., Healy, M. D., Hebbeker, T., Hebrero, G., Heck, D., Holmes, V. C., Homola, P., Hörandel, J. R., Horneffer, A., Hrabovský, M., Huege, T., Hussain, M., Iarlori, M., Insolia, A., Ionita, F., Italiano, A., Jiraskova, S., Kaducak, M., Kampert, K. H., Karova, T., Kasper, P., Kégl, B., Keilhauer, B., Kemp, E., Kieckhafer, R. M., Klages, H. O., Kleifges, M., Kleinfeller, J., Knapik, R., Knapp, J., Koang, D. -H., Krieger, A., Krömer, O., Kruppke-Hansen, D., Kuehn, F., Kuempel, D., Kulbartz, K., Kunka, N., Kusenko, A., LaRosa, G., Lachaud, C., Lago, B. L., Lautridou, P., Leão, M. S. A. B., Lebrun, D., Lebrun, P., Lee, J., de Oliveira, M. A. Leigui, Lemiere, A., Letessier-Selvon, A., Leuthold, M., Lhenry-Yvon, I., López, R., Agüera, A. Lopez, Louedec, K., Bahilo, J. Lozano, Lucero, A., Lyberis, H., Maccarone, M. C., Macolino, C., Maldera, S., Mandat, D., Mantsch, P., Mariazzi, A. G., Maris, I. C., Falcon, H. R. Marquez, Martello, D., Bravo, O. Martínez, Mathes, H. J., Matthews, J., Matthews, J. A. J., Matthiae, G., Maurizio, D., Mazur, P. O., McEwen, M., McNeil, R. R., Medina-Tanco, G., Melissas, M., Melo, D., Menichetti, E., Menshikov, A., Meyhandan, R., Micheletti, M. I., Miele, G., Miller, W., Miramonti, L., Mollerach, S., Monasor, M., Ragaigne, D. Monnier, Montanet, F., Morales, B., Morello, C., Moreno, J. C., Morris, C., Mostafá, M., Moura, C. A., Mueller, S., Muller, M. A., Mussa, R., Navarra, G., Navarro, J. L., Navas, S., Necesal, P., Nellen, L., Newman-Holmes, C., Newton, D., Nhung, P. T., Nierstenhoefer, N., Nitz, D., Nosek, D., Nožka, L., Nyklicek, M., Oehlschläger, J., Olinto, A., Oliva, P., Olmos-Gilbaja, V. M., Ortiz, M., Pacheco, N., Selmi-Dei, D. Pakk, Palatka, M., Pallotta, J., Parente, G., Parizot, E., Parlati, S., Pastor, S., Patel, M., Paul, T., Pavlidou, V., Payet, K., Pech, M., Pȩkala, J., Pepe, I. M., Perrone, L., Pesce, R., Petermann, E., Petrera, S., Petrinca, P., Petrolini, A., Petrov, Y., Petrovic, J., Pfendner, C., Piegaia, R., Pierog, T., Pimenta, M., Pinto, T., Pirronello, V., Pisanti, O., Platino, M., Pochon, J., Ponce, V. H., Pontz, M., Privitera, P., Prouza, M., Quel, E. J., Rautenberg, J., Ravel, O., Ravignani, D., Redondo, A., Revenu, B., Rezende, F. A. S., Ridky, J., Riggi, S., Risse, M., Rivière, C., Rizi, V., Robledo, C., Rodriguez, G., Martino, J. Rodriguez, Rojo, J. Rodriguez, Rodriguez-Cabo, I., Rodríguez-Frías, M. D., Ros, G., Rosado, J., Rossler, T., Roth, M., Rouillé-d'Orfeuil, B., Roulet, E., Rovero, A. C., Salamida, F., Salazar, H., Salina, G., Sánchez, F., Santander, M., Santo, C. E., Santos, E. M., Sarazin, F., Sarkar, S., Sato, R., Scharf, N., Scherini, V., Schieler, H., Schiffer, P., Schmidt, A., Schmidt, F., Schmidt, T., Scholten, O., Schoorlemmer, H., Schovancova, J., Schovánek, P., Schroeder, F., Schulte, S., Schüssler, F., Schuster, D., Sciutto, S. J., Scuderi, M., Segreto, A., Semikoz, D., Settimo, M., Shellard, R. C., Sidelnik, I., Siffert, B. B., Sigl, G., Śmiałkowski, A., Šmída, R., Smith, B. E., Snow, G. R., Sommers, P., Sorokin, J., Spinka, H., Squartini, R., Strazzeri, E., Stutz, A., Suarez, F., Suomijärvi, T., Supanitsky, A. D., Sutherland, M. S., Swain, J., Szadkowski, Z., Tamashiro, A., Tamburro, A., Tarutina, T., Taşcău, O., Tcaciuc, R., Tcherniakhovski, D., Tegolo, D., Thao, N. T., Thomas, D., Ticona, R., Tiffenberg, J., Timmermans, C., Tkaczyk, W., Peixoto, C. J. Todero, Tomé, B., Tonachini, A., Torres, I., Travnicek, P., Tridapalli, D. B., Tristram, G., Trovato, E., Tueros, M., Ulrich, R., Unger, M., Urban, M., Galicia, J. F. Valdés, Valiño, I., Valore, L., VandenBerg, A. M., Vázquez, J. R., Vázquez, R. A., Veberič, D., Velarde, A., Venters, T., Verzi, V., Videla, M., Villaseñor, L., Vorobiov, S., Voyvodic, L., Wahlberg, H., Wahrlich, P., Wainberg, O., Warner, D., Watson, A. A., Westerhoff, S., Whelan, B. J., Wieczorek, G., Wiencke, L., Wilczyńska, B., Wilczyński, H., Wileman, C., Winnick, M. G., Wu, H., Wundheiler, B., Yamamoto, T., Younk, P., Yuan, G., Yushkov, A., Zas, E., Zavrtanik, D., Zavrtanik, M., Zaw, I., Zepeda, A., and Ziolkowski, M.

Subjects
Astrophysics - Instrumentation and Methods for Astrophysics, Astrophysics - High Energy Astrophysical Phenomena
Abstract

Technical reports on operations and features of the Pierre Auger Observatory, including ongoing and planned enhancements and the status of the future northern hemisphere portion of the Observatory. Contributions to the 31st International Cosmic Ray Conference, Lodz, Poland, July 2009., Comment: Contributions to the 31st ICRC, Lodz, Poland, July 2009

Published
2009

14. Astrophysical Sources of Cosmic Rays and Related Measurements with the Pierre Auger Observatory

Author

The Pierre Auger Collaboration, Abraham, J., Abreu, P., Aglietta, M., Aguirre, C., Ahn, E. J., Allard, D., Allekotte, I., Allen, J., Alvarez-Muñiz, J., Ambrosio, M., Anchordoqui, L., Andringa, S., Anzalone, A., Aramo, C., Arganda, E., Argirò, S., Arisaka, K., Arneodo, F., Arqueros, F., Asch, T., Asorey, H., Assis, P., Aublin, J., Ave, M., Avila, G., Bäcker, T., Badagnani, D., Barber, K. B., Barbosa, A. F., Barroso, S. L. C., Baughman, B., Bauleo, P., Beatty, J. J., Beau, T., Becker, B. R., Becker, K. H., Bellétoile, A., Bellido, J. A., BenZvi, S., Berat, C., Bernardini, P., Bertou, X., Biermann, P. L., Billoir, P., Blanch-Bigas, O., Blanco, F., Bleve, C., Blümer, H., Boháčová, M., Boncioli, D., Bonifazi, C., Bonino, R., Borodai, N., Brack, J., Brogueira, P., Brown, W. C., Bruijn, R., Buchholz, P., Bueno, A., Burton, R. E., Busca, N. G., Caballero-Mora, K. S., Caramete, L., Caruso, R., Carvalho, W., Castellina, A., Catalano, O., Cazon, L., Cester, R., Chauvin, J., Chiavassa, A., Chinellato, J. A., Chou, A., Chudoba, J., Chye, J., Clay, R. W., Colombo, E., Conceição, R., Connolly, B., Contreras, F., Coppens, J., Cordier, A., Cotti, U., Coutu, S., Covault, C. E., Creusot, A., Criss, A., Cronin, J., Curutiu, A., Dagoret-Campagne, S., Dallier, R., Daumiller, K., Dawson, B. R., de Almeida, R. M., De Domenico, M., De Donato, C., de Jong, S. J., De La Vega, G., Junior, W. J. M. de Mello, Neto, J. R. T. de Mello, De Mitri, I., de Souza, V., de Vries, K. D., Decerprit, G., del Peral, L., Deligny, O., Della Selva, A., Fratte, C. Delle, Dembinski, H., DiGiulio, C., Diaz, J. C., Diep, P. N., Dobrigkeit, C., D'Olivo, J. C., Dong, P. N., Dorofeev, A., Anjos, J. C. dos, Dova, M. T., D'Urso, D., Dutan, I., DuVernois, M. A., Engel, R., Erdmann, M., Escobar, C. O., Etchegoyen, A., Luis, P. Facal San, Falcke, H., Farrar, G., Fauth, A. C., Fazzini, N., Ferrer, F., Ferrero, A., Fick, B., Filevich, A., Filipčič, A., Fleck, I., Fliescher, S., Fracchiolla, C. E., Fraenkel, E. D., Fulgione, W., Gamarra, R. F., Gambetta, S., García, B., GarcíaGámez, D., Garcia-Pinto, D., Garrido, X., Gelmini, G., Gemmeke, H., Ghia, P. L., Giaccari, U., Giller, M., Glass, H., Goggin, L. M., Gold, M. S., Golup, G., Albarracin, F. Gomez, Berisso, M. Gómez, Gonçalves, P., Amaral, M. Gonçalves do, Gonzalez, D., Gonzalez, J. G., Góra, D., Gorgi, A., Gouffon, P., Gozzini, S. R., Grashorn, E., Grebe, S., Grigat, M., Grillo, A. F., Guardincerri, Y., Guarino, F., Guedes, G. P., Gutiérrez, J., Hague, J. D., Halenka, V., Hansen, P., Harari, D., Harmsma, S., Harton, J. L., Haungs, A., Healy, M. D., Hebbeker, T., Hebrero, G., Heck, D., Holmes, V. C., Homola, P., Hörandel, J. R., Horneffer, A., Hrabovský, M., Huege, T., Hussain, M., Iarlori, M., Insolia, A., Ionita, F., Italiano, A., Jiraskova, S., Kaducak, M., Kampert, K. H., Karova, T., Kasper, P., Kégl, B., Keilhauer, B., Kemp, E., Kieckhafer, R. M., Klages, H. O., Kleifges, M., Kleinfeller, J., Knapik, R., Knapp, J., Koang, D. -H., Krieger, A., Krömer, O., Kruppke-Hansen, D., Kuehn, F., Kuempel, D., Kulbartz, K., Kunka, N., Kusenko, A., LaRosa, G., Lachaud, C., Lago, B. L., Lautridou, P., Leão, M. S. A. B., Lebrun, D., Lebrun, P., Lee, J., de Oliveira, M. A. Leigui, Lemiere, A., Letessier-Selvon, A., Leuthold, M., Lhenry-Yvon, I., López, R., Agüera, A. Lopez, Louedec, K., Bahilo, J. Lozano, Lucero, A., Lyberis, H., Maccarone, M. C., Macolino, C., Maldera, S., Mandat, D., Mantsch, P., Mariazzi, A. G., Maris, I. C., Falcon, H. R. Marquez, Martello, D., Bravo, O. Martínez, Mathes, H. J., Matthews, J., Matthews, J. A. J., Matthiae, G., Maurizio, D., Mazur, P. O., McEwen, M., McNeil, R. R., Medina-Tanco, G., Melissas, M., Melo, D., Menichetti, E., Menshikov, A., Meyhandan, R., Micheletti, M. I., Miele, G., Miller, W., Miramonti, L., Mollerach, S., Monasor, M., Ragaigne, D. Monnier, Montanet, F., Morales, B., Morello, C., Moreno, J. C., Morris, C., Mostafá, M., Moura, C. A., Mueller, S., Muller, M. A., Mussa, R., Navarra, G., Navarro, J. L., Navas, S., Necesal, P., Nellen, L., Newman-Holmes, C., Newton, D., Nhung, P. T., Nierstenhoefer, N., Nitz, D., Nosek, D., Nožka, L., Nyklicek, M., Oehlschläger, J., Olinto, A., Oliva, P., Olmos-Gilbaja, V. M., Ortiz, M., Pacheco, N., Selmi-Dei, D. Pakk, Palatka, M., Pallotta, J., Parente, G., Parizot, E., Parlati, S., Pastor, S., Patel, M., Paul, T., Pavlidou, V., Payet, K., Pech, M., Pȩkala, J., Pepe, I. M., Perrone, L., Pesce, R., Petermann, E., Petrera, S., Petrinca, P., Petrolini, A., Petrov, Y., Petrovic, J., Pfendner, C., Piegaia, R., Pierog, T., Pimenta, M., Pinto, T., Pirronello, V., Pisanti, O., Platino, M., Pochon, J., Ponce, V. H., Pontz, M., Privitera, P., Prouza, M., Quel, E. J., Rautenberg, J., Ravel, O., Ravignani, D., Redondo, A., Revenu, B., Rezende, F. A. S., Ridky, J., Riggi, S., Risse, M., Rivière, C., Rizi, V., Robledo, C., Rodriguez, G., Martino, J. Rodriguez, Rojo, J. Rodriguez, Rodriguez-Cabo, I., Rodríguez-Frías, M. D., Ros, G., Rosado, J., Rossler, T., Roth, M., Rouillé-d'Orfeuil, B., Roulet, E., Rovero, A. C., Salamida, F., Salazar, H., Salina, G., Sánchez, F., Santander, M., Santo, C. E., Santos, E. M., Sarazin, F., Sarkar, S., Sato, R., Scharf, N., Scherini, V., Schieler, H., Schiffer, P., Schmidt, A., Schmidt, F., Schmidt, T., Scholten, O., Schoorlemmer, H., Schovancova, J., Schovánek, P., Schroeder, F., Schulte, S., Schüssler, F., Schuster, D., Sciutto, S. J., Scuderi, M., Segreto, A., Semikoz, D., Settimo, M., Shellard, R. C., Sidelnik, I., Siffert, B. B., Sigl, G., Śmiałkowski, A., Šmída, R., Smith, B. E., Snow, G. R., Sommers, P., Sorokin, J., Spinka, H., Squartini, R., Strazzeri, E., Stutz, A., Suarez, F., Suomijärvi, T., Supanitsky, A. D., Sutherland, M. S., Swain, J., Szadkowski, Z., Tamashiro, A., Tamburro, A., Tarutina, T., Taşcău, O., Tcaciuc, R., Tcherniakhovski, D., Tegolo, D., Thao, N. T., Thomas, D., Ticona, R., Tiffenberg, J., Timmermans, C., Tkaczyk, W., Peixoto, C. J. Todero, Tomé, B., Tonachini, A., Torres, I., Travnicek, P., Tridapalli, D. B., Tristram, G., Trovato, E., Tueros, M., Ulrich, R., Unger, M., Urban, M., Galicia, J. F. Valdés, Valiño, I., Valore, L., vandenBerg, A. M., Vázquez, J. R., Vázquez, R. A., Veberič, D., Velarde, A., Venters, T., Verzi, V., Videla, M., Villaseñor, L., Vorobiov, S., Voyvodic, L., Wahlberg, H., Wahrlich, P., Wainberg, O., Warner, D., Watson, A. A., Westerhoff, S., Whelan, B. J., Wieczorek, G., Wiencke, L., Wilczyńska, B., Wilczyński, H., Wileman, C., Winnick, M. G., Wu, H., Wundheiler, B., Yamamoto, T., Younk, P., Yuan, G., Yushkov, A., Zas, E., Zavrtanik, D., Zavrtanik, M., Zaw, I., Zepeda, A., and Ziolkowski, M.

Subjects
Astrophysics - High Energy Astrophysical Phenomena, Astrophysics - Cosmology and Extragalactic Astrophysics
Abstract

Studies of the correlations of ultra-high energy cosmic ray directions with extra-Galactic objects, of general anisotropy, of photons and neutrinos, and of other astrophysical effects, with the Pierre Auger Observatory. Contributions to the 31st ICRC, Lodz, Poland, July 2009., Comment: Submissions to the 31st International Cosmic Ray Conference, Lodz, Poland, July 2009

Published
2009

15. Studies of Cosmic Ray Composition and Air Shower Structure with the Pierre Auger Observatory

Author

The Pierre Auger Collaboration, Abraham, J., Abreu, P., Aglietta, M., Aguirre, C., Ahn, E. J., Allard, D., Allekotte, I., Allen, J., Alvarez-Muñiz, J., Ambrosio, M., Anchordoqui, L., Andringa, S., Anzalone, A., Aramo, C., Arganda, E., Argirò, S., Arisaka, K., Arneodo, F., Arqueros, F., Asch, T., Asorey, H., Assis, P., Aublin, J., Ave, M., Avila, G., Bäcker, T., Badagnani, D., Barber, K. B., Barbosa, A. F., Barroso, S. L. C., Baughman, B., Bauleo, P., Beatty, J. J., Beau, T., Becker, B. R., Becker, K. H., Bellétoile, A., Bellido, J. A., BenZvi, S., Berat, C., Bernardini, P., Bertou, X., Biermann, P. L., Billoir, P., Blanch-Bigas, O., Blanco, F., Bleve, C., Blümer, H., Boháčová, M., Boncioli, D., Bonifazi, C., Bonino, R., Borodai, N., Brack, J., Brogueira, P., Brown, W. C., Bruijn, R., Buchholz, P., Bueno, A., Burton, R. E., Busca, N. G., Caballero-Mora, K. S., Caramete, L., Caruso, R., Carvalho, W., Castellina, A., Catalano, O., Cazon, L., Cester, R., Chauvin, J., Chiavassa, A., Chinellato, J. A., Chou, A., Chudoba, J., Chye, J., Clay, R. W., Colombo, E., Conceição, R., Connolly, B., Contreras, F., Coppens, J., Cordier, A., Cotti, U., Coutu, S., Covault, C. E., Creusot, A., Criss, A., Cronin, J., Curutiu, A., Dagoret-Campagne, S., Dallier, R., Daumiller, K., Dawson, B. R., de Almeida, R. M., De Domenico, M., De Donato, C., de Jong, S. J., De La Vega, G., Junior, W. J. M. de Mello, Neto, J. R. T. de Mello, De Mitri, I., de Souza, V., de Vries, K. D., Decerprit, G., del Peral, L., Deligny, O., Della Selva, A., Fratte, C. Delle, Dembinski, H., DiGiulio, C., Diaz, J. C., Diep, P. N., Dobrigkeit, C., D'Olivo, J. C., Dong, P. N., Dorofeev, A., Anjos, J. C. dos, Dova, M. T., D'Urso, D., Dutan, I., DuVernois, M. A., Engel, R., Erdmann, M., Escobar, C. O., Etchegoyen, A., Luis, P. Facal San, Falcke, H., Farrar, G., Fauth, A. C., Fazzini, N., Ferrer, F., Ferrero, A., Fick, B., Filevich, A., Filipčič, A., Fleck, I., Fliescher, S., Fracchiolla, C. E., Fraenkel, E. D., Fulgione, W., Gamarra, R. F., Gambetta, S., García, B., GarcíaGámez, D., Garcia-Pinto, D., Garrido, X., Gelmini, G., Gemmeke, H., Ghia, P. L., Giaccari, U., Giller, M., Glass, H., Goggin, L. M., Gold, M. S., Golup, G., Albarracin, F. Gomez, Berisso, M. Gómez, Gonçalves, P., Amaral, M. Gonçalves do, Gonzalez, D., Gonzalez, J. G., Góra, D., Gorgi, A., Gouffon, P., Gozzini, S. R., Grashorn, E., Grebe, S., Grigat, M., Grillo, A. F., Guardincerri, Y., Guarino, F., Guedes, G. P., Gutiérrez, J., Hague, J. D., Halenka, V., Hansen, P., Harari, D., Harmsma, S., Harton, J. L., Haungs, A., Healy, M. D., Hebbeker, T., Hebrero, G., Heck, D., Hojvat, C., Holmes, V. C., Homola, P., Hörandel, J. R., Horneffer, A., Hrabovský, M., Huege, T., Hussain, M., Iarlori, M., Insolia, A., Ionita, F., Italiano, A., Jiraskova, S., Kaducak, M., Kampert, K. H., Karova, T., Kasper, P., Kégl, B., Keilhauer, B., Kemp, E., Kieckhafer, R. M., Klages, H. O., Kleifges, M., Kleinfeller, J., Knapik, R., Knapp, J., Koang, D. -H., Krieger, A., Krömer, O., Kruppke-Hansen, D., Kuehn, F., Kuempel, D., Kulbartz, K., Kunka, N., Kusenko, A., LaRosa, G., Lachaud, C., Lago, B. L., Lautridou, P., Leão, M. S. A. B., Lebrun, D., Lebrun, P., Lee, J., de Oliveira, M. A. Leigui, Lemiere, A., Letessier-Selvon, A., Leuthold, M., Lhenry-Yvon, I., López, R., Agüera, A. Lopez, Louedec, K., Bahilo, J. Lozano, Lucero, A., Lyberis, H., Maccarone, M. C., Macolino, C., Maldera, S., Mandat, D., Mantsch, P., Mariazzi, A. G., Maris, I. C., Falcon, H. R. Marquez, Martello, D., Bravo, O. Martínez, Mathes, H. J., Matthews, J., Matthews, J. A. J., Matthiae, G., Maurizio, D., Mazur, P. O., McEwen, M., McNeil, R. R., Medina-Tanco, G., Melissas, M., Melo, D., Menichetti, E., Menshikov, A., Meyhandan, R., Micheletti, M. I., Miele, G., Miller, W., Miramonti, L., Mollerach, S., Monasor, M., Ragaigne, D. Monnier, Montanet, F., Morales, B., Morello, C., Moreno, J. C., Morris, C., Mostafá, M., Moura, C. A., Mueller, S., Muller, M. A., Mussa, R., Navarra, G., Navarro, J. L., Navas, S., Necesal, P., Nellen, L., Newman-Holmes, C., Newton, D., Nhung, P. T., Nierstenhoefer, N., Nitz, D., Nosek, D., Nožka, L., Nyklicek, M., Oehlschläger, J., Olinto, A., Oliva, P., Olmos-Gilbaja, V. M., Ortiz, M., Pacheco, N., Selmi-Dei, D. Pakk, Palatka, M., Pallotta, J., Parente, G., Parizot, E., Parlati, S., Pastor, S., Patel, M., Paul, T., Pavlidou, V., Payet, K., Pech, M., Pȩkala, J., Pepe, I. M., Perrone, L., Pesce, R., Petermann, E., Petrera, S., Petrinca, P., Petrolini, A., Petrov, Y., Petrovic, J., Pfendner, C., Piegaia, R., Pierog, T., Pimenta, M., Pinto, T., Pirronello, V., Pisanti, O., Platino, M., Pochon, J., Ponce, V. H., Pontz, M., Privitera, P., Prouza, M., Quel, E. J., Rautenberg, J., Ravel, O., Ravignani, D., Redondo, A., Revenu, B., Rezende, F. A. S., Ridky, J., Riggi, S., Risse, M., Rivière, C., Rizi, V., Robledo, C., Rodriguez, G., Martino, J. Rodriguez, Rojo, J. Rodriguez, Rodriguez-Cabo, I., Rodríguez-Frías, M. D., Ros, G., Rosado, J., Rossler, T., Roth, M., Rouillé-d'Orfeuil, B., Roulet, E., Rovero, A. C., Salamida, F., Salazar, H., Salina, G., Sánchez, F., Santander, M., Santo, C. E., Santos, E. M., Sarazin, F., Sarkar, S., Sato, R., Scharf, N., Scherini, V., Schieler, H., Schiffer, P., Schmidt, A., Schmidt, F., Schmidt, T., Scholten, O., Schoorlemmer, H., Schovancova, J., Schovánek, P., Schroeder, F., Schulte, S., Schüssler, F., Schuster, D., Sciutto, S. J., Scuderi, M., Segreto, A., Semikoz, D., Settimo, M., Shellard, R. C., Sidelnik, I., Siffert, B. B., Sigl, G., Śmiałkowski, A., Šmída, R., Smith, B. E., Snow, G. R., Sommers, P., Sorokin, J., Spinka, H., Squartini, R., Strazzeri, E., Stutz, A., Suarez, F., Suomijärvi, T., Supanitsky, A. D., Sutherland, M. S., Swain, J., Szadkowski, Z., Tamashiro, A., Tamburro, A., Tarutina, T., Taşcău, O., Tcaciuc, R., Tcherniakhovski, D., Tegolo, D., Thao, N. T., Thomas, D., Ticona, R., Tiffenberg, J., Timmermans, C., Tkaczyk, W., Peixoto, C. J. Todero, Tomé, B., Tonachini, A., Torres, I., Travnicek, P., Tridapalli, D. B., Tristram, G., Trovato, E., Tueros, M., Ulrich, R., Unger, M., Urban, M., Galicia, J. F. Valdés, Valiño, I., Valore, L., vandenBerg, A. M., Vázquez, J. R., Vázquez, R. A., Veberič, D., Velarde, A., Venters, T., Verzi, V., Videla, M., Villaseñor, L., Vorobiov, S., Voyvodic, L., Wahlberg, H., Wahrlich, P., Wainberg, O., Warner, D., Watson, A. A., Westerhoff, S., Whelan, B. J., Wieczorek, G., Wiencke, L., Wilczyńska, B., Wilczyński, H., Wileman, C., Winnick, M. G., Wu, H., Wundheiler, B., Yamamoto, T., Younk, P., Yuan, G., Yushkov, A., Zas, E., Zavrtanik, D., Zavrtanik, M., Zaw, I., Zepeda, A., and Ziolkowski, M.

Subjects
Astrophysics - Cosmology and Nongalactic Astrophysics, Astrophysics - High Energy Astrophysical Phenomena
Abstract

Studies of the composition of the highest energy cosmic rays with the Pierre Auger Observatory, including examination of hadronic physics effects on the structure of extensive air showers. Submissions to the 31st ICRC, Lodz, Poland (July 2009)., Comment: Submissions to the 31st International Cosmic Ray Conference, Lodz, Poland (July 2009)

Published
2009

16. The Cosmic Ray Energy Spectrum and Related Measurements with the Pierre Auger Observatory

Author

The Pierre Auger Collaboration, Abraham, J., Abreu, P., Aglietta, M., Aguirre, C., Ahn, E. J., Allard, D., Allekotte, I., Allen, J., Alvarez-Muñiz, J., Ambrosio, M., Anchordoqui, L., Andringa, S., Anzalone, A., Aramo, C., Arganda, E., Argirò, S., Arisaka, K., Arneodo, F., Arqueros, F., Asch, T., Asorey, H., Assis, P., Aublin, J., Ave, M., Avila, G., Bäcker, T., Badagnani, D., Barber, K. B., Barbosa, A. F., Barroso, S. L. C., Baughman, B., Bauleo, P., Beatty, J. J., Beau, T., Becker, B. R., Becker, K. H., Bellétoile, A., Bellido, J. A., BenZvi, S., Berat, C., Bernardini, P., Bertou, X., Biermann, P. L., Billoir, P., Blanch-Bigas, O., Blanco, F., Bleve, C., Blümer, H., Boháčová, M., Boncioli, D., Bonifazi, C., Bonino, R., Borodai, N., Brack, J., Brogueira, P., Brown, W. C., Bruijn, R., Buchholz, P., Bueno, A., Burton, R. E., Busca, N. G., Caballero-Mora, K. S., Caramete, L., Caruso, R., Carvalho, W., Castellina, A., Catalano, O., Cazon, L., Cester, R., Chauvin, J., Chiavassa, A., Chinellato, J. A., Chou, A., Chudoba, J., Chye, J., Clay, R. W., Colombo, E., Conceição, R., Connolly, B., Contreras, F., Coppens, J., Cordier, A., Cotti, U., Coutu, S., Covault, C. E., Creusot, A., Criss, A., Cronin, J., Curutiu, A., Dagoret-Campagne, S., Dallier, R., Daumiller, K., Dawson, B. R., de Almeida, R. M., De Domenico, M., De Donato, C., de Jong, S. J., De La Vega, G., Junior, W. J. M. de Mello, Neto, J. R. T. de Mello, De Mitri, I., de Souza, V., de Vries, K. D., Decerprit, G., del Peral, L., Deligny, O., Della Selva, A., Fratte, C. Delle, Dembinski, H., DiGiulio, C., Diaz, J. C., Diep, P. N., Dobrigkeit, C., D'Olivo, J. C., Dong, P. N., Dorofeev, A., Anjos, J. C. dos, Dova, M. T., D'Urso, D., Dutan, I., DuVernois, M. A., Engel, R., Erdmann, M., Escobar, C. O., Etchegoyen, A., Luis, P. Facal San, Falcke, H., Farrar, G., Fauth, A. C., Fazzini, N., Ferrer, F., Ferrero, A., Fick, B., Filevich, A., Filipčič, A., Fleck, I., Fliescher, S., Fracchiolla, C. E., Fraenkel, E. D., Fulgione, W., Gamarra, R. F., Gambetta, S., García, B., GarcíaGámez, D., Garcia-Pinto, D., Garrido, X., Gelmini, G., Gemmeke, H., Ghia, P. L., Giaccari, U., Giller, M., Glass, H., Goggin, L. M., Gold, M. S., Golup, G., Albarracin, F. Gomez, Berisso, M. Gómez, Gonçalves, P., Amaral, M. Gonçalves do, Gonzalez, D., Gonzalez, J. G., Góra, D., Gorgi, A., Gouffon, P., Gozzini, S. R., Grashorn, E., Grebe, S., Grigat, M., Grillo, A. F., Guardincerri, Y., Guarino, F., Guedes, G. P., Gutiérrez, J., Hague, J. D., Halenka, V., Hansen, P., Harari, D., Harmsma, S., Harton, J. L., Haungs, A., Healy, M. D., Hebbeker, T., Hebrero, G., Heck, D., Holmes, V. C., Homola, P., Hörandel, J. R., Horneffer, A., Hrabovský, M., Huege, T., Hussain, M., Iarlori, M., Insolia, A., Ionita, F., Italiano, A., Jiraskova, S., Kaducak, M., Kampert, K. H., Karova, T., Kasper, P., Kégl, B., Keilhauer, B., Kemp, E., Kieckhafer, R. M., Klages, H. O., Kleifges, M., Kleinfeller, J., Knapik, R., Knapp, J., Koang, D. -H., Krieger, A., Krömer, O., Kruppke-Hansen, D., Kuehn, F., Kuempel, D., Kulbartz, K., Kunka, N., Kusenko, A., LaRosa, G., Lachaud, C., Lago, B. L., Lautridou, P., Leão, M. S. A. B., Lebrun, D., Lebrun, P., Lee, J., de Oliveira, M. A. Leigui, Lemiere, A., Letessier-Selvon, A., Leuthold, M., Lhenry-Yvon, I., López, R., Agüera, A. Lopez, Louedec, K., Bahilo, J. Lozano, Lucero, A., Lyberis, H., Maccarone, M. C., Macolino, C., Maldera, S., Mandat, D., Mantsch, P., Mariazzi, A. G., Maris, I. C., Falcon, H. R. Marquez, Martello, D., Bravo, O. Martínez, Mathes, H. J., Matthews, J., Matthews, J. A. J., Matthiae, G., Maurizio, D., Mazur, P. O., McEwen, M., McNeil, R. R., Medina-Tanco, G., Melissas, M., Melo, D., Menichetti, E., Menshikov, A., Meyhandan, R., Micheletti, M. I., Miele, G., Miller, W., Miramonti, L., Mollerach, S., Monasor, M., Ragaigne, D. Monnier, Montanet, F., Morales, B., Morello, C., Moreno, J. C., Morris, C., Mostafá, M., Moura, C. A., Mueller, S., Muller, M. A., Mussa, R., Navarra, G., Navarro, J. L., Navas, S., Necesal, P., Nellen, L., Newman-Holmes, C., Newton, D., Nhung, P. T., Nierstenhoefer, N., Nitz, D., Nosek, D., Nožka, L., Nyklicek, M., Oehlschläger, J., Olinto, A., Oliva, P., Olmos-Gilbaja, V. M., Ortiz, M., Pacheco, N., Selmi-Dei, D. Pakk, Palatka, M., Pallotta, J., Parente, G., Parizot, E., Parlati, S., Pastor, S., Patel, M., Paul, T., Pavlidou, V., Payet, K., Pech, M., Pȩkala, J., Pepe, I. M., Perrone, L., Pesce, R., Petermann, E., Petrera, S., Petrinca, P., Petrolini, A., Petrov, Y., Petrovic, J., Pfendner, C., Piegaia, R., Pierog, T., Pimenta, M., Pinto, T., Pirronello, V., Pisanti, O., Platino, M., Pochon, J., Ponce, V. H., Pontz, M., Privitera, P., Prouza, M., Quel, E. J., Rautenberg, J., Ravel, O., Ravignani, D., Redondo, A., Revenu, B., Rezende, F. A. S., Ridky, J., Riggi, S., Risse, M., Rivière, C., Rizi, V., Robledo, C., Rodriguez, G., Martino, J. Rodriguez, Rojo, J. Rodriguez, Rodriguez-Cabo, I., Rodríguez-Frías, M. D., Ros, G., Rosado, J., Rossler, T., Roth, M., Rouillé-d'Orfeuil, B., Roulet, E., Rovero, A. C., Salamida, F., Salazar, H., Salina, G., Sánchez, F., Santander, M., Santo, C. E., Santos, E. M., Sarazin, F., Sarkar, S., Sato, R., Scharf, N., Scherini, V., Schieler, H., Schiffer, P., Schmidt, A., Schmidt, F., Schmidt, T., Scholten, O., Schoorlemmer, H., Schovancova, J., Schovánek, P., Schroeder, F., Schulte, S., Schüssler, F., Schuster, D., Sciutto, S. J., Scuderi, M., Segreto, A., Semikoz, D., Settimo, M., Shellard, R. C., Sidelnik, I., Siffert, B. B., Sigl, G., Śmiałkowski, A., Šmída, R., Smith, B. E., Snow, G. R., Sommers, P., Sorokin, J., Spinka, H., Squartini, R., Strazzeri, E., Stutz, A., Suarez, F., Suomijärvi, T., Supanitsky, A. D., Sutherland, M. S., Swain, J., Szadkowski, Z., Tamashiro, A., Tamburro, A., Tarutina, T., Taşcău, O., Tcaciuc, R., Tcherniakhovski, D., Tegolo, D., Thao, N. T., Thomas, D., Ticona, R., Tiffenberg, J., Timmermans, C., Tkaczyk, W., Peixoto, C. J. Todero, Tomé, B., Tonachini, A., Torres, I., Travnicek, P., Tridapalli, D. B., Tristram, G., Trovato, E., Tueros, M., Ulrich, R., Unger, M., Urban, M., Galicia, J. F. Valdés, Valiño, I., Valore, L., vandenBerg, A. M., Vázquez, J. R., Vázquez, R. A., Veberič, D., Velarde, A., Venters, T., Verzi, V., Videla, M., Villaseñor, L., Vorobiov, S., Voyvodic, L., Wahlberg, H., Wahrlich, P., Wainberg, O., Warner, D., Watson, A. A., Westerhoff, S., Whelan, B. J., Wieczorek, G., Wiencke, L., Wilczyńska, B., Wilczyński, H., Wileman, C., Winnick, M. G., Wu, H., Wundheiler, B., Yamamoto, T., Younk, P., Yuan, G., Yushkov, A., Zas, E., Zavrtanik, D., Zavrtanik, M., Zaw, I., Zepeda, A., and Ziolkowski, M.

Subjects
Astrophysics - High Energy Astrophysical Phenomena
Abstract

Studies of the cosmic ray energy spectrum at the highest energies with the Pierre Auger Observatory., Comment: Submissions to the 31st International Cosmic Ray Conference

Published
2009

17. Upper limit on the cosmic-ray photon fraction at EeV energies from the Pierre Auger Observatory

Author

The Pierre Auger Collaboration, Abraham, J., Abreu, P., Aglietta, M., Aguirre, C., Ahn, E. J., Allard, D., Allekotte, I., Allen, J., Allison, P., Alvarez-Muñiz, J., Ambrosio, M., Anchordoqui, L., Andringa, S., Anzalone, A., Aramo, C., Argiró, S., Arisaka, K., Arneodo, F., Arqueros, F., Asch, T., Asorey, H., Assis, P., Aublin, J., Ave, M., Avila, G., Bäcker, T., Badagnani, D., Barber, K. B., Barbosa, A. F., Barroso, S. L. C., Baughman, B., Bauleo, P., Beatty, J. J., Beau, T., Becker, B. R., Becker, K. H., Bellétoile, A., Bellido, J. A., BenZvi, S., Berat, C., Bernardini, P., Bertou, X., Biermann, P. L., Billoir, P., Blanch-Bigas, O., Blanco, F., Bleve, C., Blümer, H., Boháčová, M., Bonifazi, C., Bonino, R., Brack, J., Brogueira, P., Brown, W. C., Bruijn, R., Buchholz, P., Bueno, A., Burton, R. E., Busca, N. G., Caballero-Mora, K. S., Caramete, L., Caruso, R., Carvalho, W., Castellina, A., Catalano, O., Cazon, L., Cester, R., Chauvin, J., Chiavassa, A., Chinellato, J. A., Chou, A., Chudoba, J., Chye, J., Clay, R. W., Colombo, E., Conceição, R., Connolly, B., Contreras, F., Coppens, J., Cordier, A., Cotti, U., Coutu, S., Covault, C. E., Creusot, A., Criss, A., Cronin, J., Curutiu, A., Dagoret-Campagne, S., Daumiller, K., Dawson, B. R., de Almeida, R. M., De Domenico, M., De Donato, C., de Jong, S. J., De La Vega, G., Junior, W. J. M. de Mello, Neto, J. R. T. de Mello, De Mitri, I., de Souza, V., Decerprit, G., del Peral, L., Deligny, O., Della Selva, A., Fratte, C. Delle, Dembinski, H., Di Giulio, C., Diaz, J. C., Diep, P. N., Dobrigkeit, C., D'Olivo, J. C., Dong, P. N., Dornic, D., Dorofeev, A., Anjos, J. C. dos, Dova, M. T., D'Urso, D., Dutan, I., DuVernois, M. A., Engel, R., Erdmann, M., Escobar, C. O., Etchegoyen, A., Luis, P. Facal San, Falcke, H., Farrar, G., Fauth, A. C., Fazzini, N., Ferrer, F., Ferrero, A., Fick, B., Filevich, A., Filipçiç, A., Fleck, I., Fliescher, S., Fracchiolla, C. E., Fraenkel, E. D., Fulgione, W., Gamarra, R. F., Gambetta, S., García, B., Gámez, D. García, Garcia-Pinto, D., Garrido, X., Gelmini, G., Gemmeke, H., Ghia, P. L., Giaccari, U., Giller, M., Glass, H., Goggin, L. M., Gold, M. S., Golup, G., Albarracin, F. Gomez, Berisso, M. Gómez, Gonçalves, P., Amaral, M. Gonçalves do, Gonzalez, D., Gonzalez, J. G., Góra, D., Gorgi, A., Gouffon, P., Grebe, S., Grigat, M., Grillo, A. F., Guardincerri, Y., Guarino, F., Guedes, G. P., Gutiérrez, J., Hague, J. D., Halenka, V., Hansen, P., Harari, D., Harmsma, S., Harton, J. L., Haungs, A., Healy, M. D., Hebbeker, T., Hebrero, G., Heck, D., Hojvat, C., Holmes, V. C., Homola, P., Hörandel, J. R., Horneffer, A., Hrabovský, M., Huege, T., Hussain, M., Iarlori, M., Insolia, A., Ionita, F., Italiano, A., Jiraskova, S., Kaducak, M., Kampert, K. H., Karova, T., Kasper, P., Kégl, B., Keilhauer, B., Kemp, E., Kieckhafer, R. M., Klages, H. O., Kleifges, M., Kleinfeller, J., Knapik, R., Knapp, J., Koang, D. -H., Krieger, A., Krömer, O., Kruppke, D., Kuempel, D., Kunka, N., Kusenko, A., La Rosa, G., Lachaud, C., Lago, B. L., Leão, M. S. A. B., Lebrun, D., Lebrun, P., Lee, J., de Oliveira, M. A. Leigui, Lemiere, A., Letessier-Selvon, A., Leuthold, M., Lhenry-Yvon, I., López, R., Agüera, A. Lopez, Bahilo, J. Lozano, Lucero, A., García, R. Luna, Maccarone, M. C., Macolino, C., Maldera, S., Mandat, D., Mantsch, P., Mariazzi, A. G., Maris, I. C., Falcon, H. R. Marquez, Martello, D., Martínez, J., Bravo, O. Martínez, Mathes, H. J., Matthews, J., Matthews, J. A. J., Matthiae, G., Maurizio, D., Mazur, P. O., McEwen, M., McNeil, R. R., Medina-Tanco, G., Melissas, M., Melo, D., Menichetti, E., Menshikov, A., Meyhandan, R., Micheletti, M. I., Miele, G., Miller, W., Miramonti, L., Mollerach, S., Monasor, M., Ragaigne, D. Monnier, Montanet, F., Morales, B., Morello, C., Moreno, J. C., Morris, C., Mostafá, M., Mueller, S., Muller, M. A., Mussa, R., Navarra, G., Navarro, J. L., Navas, S., Necesal, P., Nellen, L., Newman-Holmes, C., Newton, D., Nhung, P. T., Nierstenhoefer, N., Nitz, D., Nosek, D., Nožka, L., Oehlschläger, J., Olinto, A., Olmos-Gilbaja, V. M., Ortiz, M., Ortolani, F., Pacheco, N., Selmi-Dei, D. Pakk, Palatka, M., Pallotta, J., Parente, G., Parizot, E., Parlati, S., Pastor, S., Patel, M., Paul, T., Pavlidou, V., Payet, K., Pech, M., Pȩkala, J., Pelayo, R., Pepe, I. M., Perrone, L., Pesce, R., Petermann, E., Petrera, S., Petrinca, P., Petrolini, A., Petrov, Y., Petrovic, J., Pfendner, C., Pichel, A., Piegaia, R., Pierog, T., Pimenta, M., into, T. P, Pirronello, V., Pisanti, O., Platino, M., Pochon, J., Ponce, V. H., Pontz, M., Privitera, P., Prouza, M., Quel, E. J., Rautenberg, J., Ravignani, D., Redondo, A., Reucroft, S., Revenu, B., Rezende, F. A. S., Ridky, J., Riggi, S., Risse, M., Riviére, C., Rizi, V., Robledo, C., Rodriguez, G., Martino, J. Rodriguez, Rojo, J. Rodriguez, Rodriguez-Cabo, I., Rodríguez-Frías, M. D., Ros, G., Rosado, J., Roth, M., Rouillé-d'Orfeuil, B., Roulet, E., Rovero, A. C., Salamida, F., Salazar, H., Salina, G., Sánchez, F., Santander, M., Santo, C. E., Santos, E. M., Sarazin, F., Sarkar, S., Sato, R., Scharf, N., Scherini, V., Schieler, H., Schiffer, P., Schmidt, A., Schmidt, F., Schmidt, T., Scholten, O., Schoorlemmer, H., Schovancova, J., Schovánek, P., Schroeder, F., Schulte, S., Schüssler, F., Schuster, D., Sciutto, S. J., Scuderi, M., Segreto, A., Semikoz, D., Settimo, M., Shellard, R. C., Sidelnik, I., Siffert, B. B., De Grande, N. Smetniansky, Smiałkowski, A., Šmída, R., Smith, B. E., Snow, G. R., Sommers, P., Sorokin, J., Spinka, H., Squartini, R., Strazzeri, E., Stutz, A., Suarez, F., Suomijärvi, T., Supanitsky, A. D., Sutherland, M. S., Swain, J., Szadkowski, Z., Tamashiro, A., Tamburro, A., Tarutina, T., Taşcǎu, O., Tcaciuc, R., Tcherniakhovski, D., Thao, N. T., Thomas, D., Ticona, R., Tiffenberg, J., Timmermans, C., Tkaczyk, W., Peixoto, C. J. Todero, Tomé, B., Tonachini, A., Torres, I., Travnicek, P., Tridapalli, D. B., Tristram, G., Trovato, E., Tuci, V., Tueros, M., Ulrich, R., Unger, M., Urban, M., Galicia, J. F. Valdés, Valiño, I., Valore, L., Berg, A. M. van den, Vázquez, R. A., Veberič, D., Velarde, A., Venters, T., Verzi, V., Videla, M., Villaseñor, L., Vorobiov, S., Voyvodic, L., Wahlberg, H., Wahrlich, P., Wainberg, O., Warner, D., Watson, A. A., Westerhoff, S., Whelan, B. J., Wieczorek, G., Wiencke, L., Wilczyńska, B., Wilczyński, H., Wileman, C., Winnick, M. G., Wu, H., Wundheiler, B., Younk, P., Yuan, G., Zas, E., Zavrtanik, D., Zavrtanik, M., Zaw, I., Zepeda, A., and Ziolkowski, M.

Subjects
Astrophysics - High Energy Astrophysical Phenomena
Abstract

From direct observations of the longitudinal development of ultra-high energy air showers performed with the Pierre Auger Observatory, upper limits of 3.8%, 2.4%, 3.5% and 11.7% (at 95% c.l.) are obtained on the fraction of cosmic-ray photons above 2, 3, 5 and 10 EeV (1 EeV = 10^18 eV) respectively. These are the first experimental limits on ultra-high energy photons at energies below 10 EeV. The results complement previous constraints on top-down models from array data and they reduce systematic uncertainties in the interpretation of shower data in terms of primary flux, nuclear composition and proton-air cross-section., Comment: 20 pages, 7 figures, 2 tables. Minor changes. Accepted by Astroparticle Physics

Published
2009
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18. iPSC: HUMAN IPSC ORGANOID PRODUCTION FOR PATIENT-SPECIFIC LIVER BIOFABRICATION

Author

Martins-Santos, R., primary, Rodrigues, K.M., additional, Oliveira, J., additional, Paranhos, B.A., additional, Amorim, É., additional, de Leiros Ferreira, J. Pereira, additional, Barbosa Freire, G. Roldão, additional, Mitrach, M., additional, de Souza, M. Goncalves, additional, Condorelli, L. Bettencourt, additional, Batista, L., additional, and Goldenberg, R., additional

Published
2023
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19. Insomnia and nightmare profiles during the COVID-19 pandemic in Portugal: characterization and associated factors

Author

M. Goncalves, A. Henriques, A.R. Costa, D. Correia, M. Severo, R. Lucas, H. Barros, Ana Cristina Santos, Ana Isabel Ribeiro, Artur Rocha, Carla Lopes, Daniela Correia, Elisabete Ramos, Gonçalo Gonçalves, Henrique Barros, Joana Araújo, Makram Talih, Margarida Tavares, Milton Severo, Nuno Lunet, Paula Meireles, Raquel Duarte, Raquel Lucas, Rui Camacho, Sílvia Fraga, Sofia Correia, Susana Silva, and Teresa Leão

Subjects
Portugal, SARS-CoV-2, COVID-19, General Medicine, Dreams, Cohort Studies, Nightmares, Sleep Initiation and Maintenance Disorders, Communicable Disease Control, Insomnia symptoms, Humans, Female, Original Article, Pandemics, Prospective studies
Abstract

Objective/background To describe and characterize insomnia symptoms and nightmare profiles in Portugal during the first six weeks of a national lockdown due to COVID-19. Patients/methods An open cohort study was conducted to collect information of the general population during the first wave of SARS-CoV-2/COVID-19 pandemic in Portugal. We analyzed data from 5011 participants (≥16 years) who answered a weekly questionnaire about their well-being. Two questions about the frequency of insomnia and nightmares about COVID-19 were consecutively applied during six weeks (March–May 2020). Latent class analysis was conducted and different insomnia and nightmare profiles were identified. Associations between individual characteristics and both profiles were estimated using odds ratios (ORs) and 95% confidence intervals (CI). Results Five insomnia (No insomnia, Stable-mild, Decreasing-moderate, Stable-severe, Increasing-severe) and three nightmares profiles (Stable-mild, Stable-moderate, Stable-severe) were identified. Being female, younger, perceiving their income as insufficient and feelings of fear towards COVID-19 were associated with higher odds of insomnia (Women: OR = 6.98 95%CI: 4.18–11.64; ≥60 years: OR = 0.30 95%CI: 0.18–0.53; Insufficient income: adjusted OR (aOR) = 8.413 95%CI: 3.93–16.84; Often presenting fear of being infected with SARS-CoV-2 infection: aOR = 9.13 95%CI: 6.36–13.11), and nightmares (Women: OR = 2.60 95%CI: 1.74–3.86; ≥60 years: OR = 0.45 95%CI: 0.28–0.74; Insufficient income: aOR = 2.60 95%CI: 1.20–5.20; Often/almost always presenting fear of being infected with SARS-CoV-2 infection: aOR = 6.62 95%CI: 5.01–8.74). Having a diagnosis of SARS-CoV-2 virus infection was associated with worse patterns of nightmares about the pandemic. Conclusions Social and psychological individual factors are important characteristics to consider in the development of therapeutic strategies to support people with sleep problems during the COVID-19 pandemic.

Published
2022
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20. Blocking CHOP-dependent TXNIP shuttling to mitochondria attenuates albuminuria and mitigates kidney injury in nephrotic syndrome

Author

Sun-Ji Park, Yeawon Kim, Chuang Li, Junwoo Suh, Jothilingam Sivapackiam, Tassia M. Goncalves, George Jarad, Guoyan Zhao, Fumihiko Urano, Vijay Sharma, and Ying Maggie Chen

Subjects
Cell Nucleus, Multidisciplinary, Nephrotic Syndrome, Inflammasomes, Apoptosis, Kidney, MAP Kinase Kinase Kinase 5, Mitochondria, Mitochondrial Proteins, Mice, Thioredoxins, NLR Family, Pyrin Domain-Containing 3 Protein, Albuminuria, Animals, Carrier Proteins, Reactive Oxygen Species, Gene Deletion, Transcription Factor CHOP
Abstract

Albuminuria is a hallmark of glomerular disease of various etiologies. It is not only a symptom of glomerular disease but also a cause leading to glomerulosclerosis, interstitial fibrosis, and eventually, a decline in kidney function. The molecular mechanism underlying albuminuria-induced kidney injury remains poorly defined. In our genetic model of nephrotic syndrome (NS), we have identified CHOP (C/EBP homologous protein)-TXNIP (thioredoxin-interacting protein) as critical molecular linkers between albuminuria-induced ER dysfunction and mitochondria dyshomeostasis. TXNIP is a ubiquitously expressed redox protein that binds to and inhibits antioxidant enzyme, cytosolic thioredoxin 1 (Trx1), and mitochondrial Trx2. However, very little is known about the regulation and function of TXNIP in NS. By utilizing Chop −/− and Txnip −/− mice as well as 68 Ga-Galuminox, our molecular imaging probe for detection of mitochondrial reactive oxygen species (ROS) in vivo, we demonstrate that CHOP up-regulation induced by albuminuria drives TXNIP shuttling from nucleus to mitochondria, where it is required for the induction of mitochondrial ROS. The increased ROS accumulation in mitochondria oxidizes Trx2, thus liberating TXNIP to associate with mitochondrial nod-like receptor protein 3 (NLRP3) to activate inflammasome, as well as releasing mitochondrial apoptosis signal-regulating kinase 1 (ASK1) to induce mitochondria-dependent apoptosis. Importantly, inhibition of TXNIP translocation and mitochondrial ROS overproduction by CHOP deletion suppresses NLRP3 inflammasome activation and p-ASK1–dependent mitochondria apoptosis in NS. Thus, targeting TXNIP represents a promising therapeutic strategy for the treatment of NS.

Published
2023

21. iPSC: HUMAN IPSC ORGANOID PRODUCTION FOR PATIENT-SPECIFIC LIVER BIOFABRICATION

Author

R. Martins-Santos, K.M. Rodrigues, J. Oliveira, B.A. Paranhos, É. Amorim, J. Pereira de Leiros Ferreira, G. Roldão Barbosa Freire, M. Mitrach, M. Goncalves de Souza, L. Bettencourt Condorelli, L. Batista, and R. Goldenberg

Subjects
Cancer Research, Transplantation, Oncology, Immunology, Immunology and Allergy, Cell Biology, Genetics (clinical)
Published
2023
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23. Optimization of magnetization transfer contrast for EPI FLAIR brain imaging

Author

Serdest Demir, Bryan Clifford, Wei‐Ching Lo, Azadeh Tabari, Augusto Lio M. Goncalves Filho, Min Lang, Stephen F. Cauley, Kawin Setsompop, Berkin Bilgic, Michael H. Lev, Pamela W. Schaefer, Otto Rapalino, Susie Y. Huang, Tom Hilbert, Thorsten Feiweier, and John Conklin

Subjects
Echo-Planar Imaging, Brain, Humans, Neuroimaging, Radiology, Nuclear Medicine and imaging, Gray Matter, Magnetic Resonance Imaging, White Matter, Article
Abstract

To evaluate the impact of magnetization transfer (MT) on brain tissue contrast in turbo-spin-echo (TSE) and EPI fluid-attenuated inversion recovery (FLAIR) images, and to optimize an MT-prepared EPI FLAIR pulse sequence to match the tissue contrast of a clinical reference TSE FLAIR protocol.Five healthy volunteers underwent 3T brain MRI, including single slice TSE FLAIR, multi-slice TSE FLAIR, EPI FLAIR without MT-preparation, and MT-prepared EPI FLAIR with variations of the MT-preparation parameters, including number of preparation pulses, pulse amplitude, and resonance offset. Automated co-registration and gray matter (GM) versus white matter (WM) segmentation was performed using a T1-MPRAGE acquisition, and the GM versus WM signal intensity ratio (contrast ratio) was calculated for each FLAIR acquisition.Without MT preparation, EPI FLAIR showed poor tissue contrast (contrast ratio = 0.98), as did single slice TSE FLAIR. Multi-slice TSE FLAIR provided high tissue contrast (contrast ratio = 1.14). MT-prepared EPI FLAIR closely approximated the contrast of the multi-slice TSE FLAIR images for two combinations of the MT-preparation parameters (contrast ratio = 1.14). Optimized MT-prepared EPI FLAIR provided a 50% reduction in scan time compared to the reference TSE FLAIR acquisition.Optimized MT-prepared EPI FLAIR provides comparable brain tissue contrast to the multi-slice TSE FLAIR images used in clinical practice.

Published
2022
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24. Prediction of gas production rate from shale gas reservoirs using a micro–macro analysis

Author

Dantong Lin, Di Zhang, Xinghao Zhang, Bruno M. Goncalves da Silva, Liming Hu, and Jay N. Meegoda

Subjects
Multidisciplinary
Abstract

Shale gas has become one of the important contributors to the global energy supply. The declining pattern of the gas production rate with time from an unconventional gas reservoir is due to the depletion of shale gas stored in the nanovoids of the shale formation. However, there are only limited ways to predict the variation of the gas production rate with time from an unconventional gas reservoir. This is due to the multiple transport mechanisms of gas in nano-scale pores and changes in shale gas permeability with pressures in nano-scale pores, which is impacted by the pore structure of the shale. In this study, the permeability-pressure (K-p) relationship for different shales (Eagle Ford, Haynesville, Longmaxi and Opalinus) were determined using an equivalent anisotropic pore network model (PNM). This PNM has REV-scale shale gas flow in randomly generated nanovoids and their connection in the shale matrix, and the multiphase flow of shale gas including viscous flow, slip flow and Knudsen diffusion. These predicted K-p correlations were then used in a finite element model (FEM) to predict the variation of the gas production rate with time (flux-time curves) at the macroscale. The simulation results show that the flux-time curves can be simplified to two linear segments in logarithmic coordinates, which are influenced by the fracture length and initial gas pressure. The predicted results using the PNM-FEM were validated by comparing them with the reported field test data. The method described in this study can be used to upscale the gas transport process from micro- to macroscale, which can provide a predictive tool for the gas production in shales.

Published
2023
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25. Os efeitos da pandemia da COVID-19 na permanência na educação superior. O cenário de uma universidade federal brasileira

Author

Chaiane de Medeiros Rosa, F. F. T. dos Santos, and A. M. Goncalves

Subjects
covid-19, evasão, educação superior, Education (General), General Medicine, permanência estudantil, L7-991
Abstract

espanolEste estudo se propos a pensar os efeitos da pandemia causada pela Covid-19 na per-manencia dos estudantes da educacao superior na Universidade Federal de Goias, no Brasil. Para responder essa questao, foi feita pesquisa documental com base em dados primarios relativos a situacao de vinculo dos estudantes em dois periodos do primeiro semestre letivo de 2020, antes e a partir da pandemia, considerando tanto o panorama geral da universidade, como as particularidades das areas do conhecimento, do ano de ingresso na instituicao e dos graus academicos. Alem disso, para subsidiar a analise dos dados, a pesquisa documental se valeu de documentos oficiais secunda-rios do Ministerio da Educacao e da Universidade Federal de Goias, principalmente, mas tambem do Instituto de Pesquisa Economica Aplicada e da Associacao Nacional dos Dirigentes das Instituicoes Federais de Ensino Superior. Ainda, foi feita pesquisa bibliografica, ancorada em autores que discutem evasao, permanencia estudantil e educacao no contexto da pandemia. Como resultado, o estudo mostrou que houve uma reducao dos vinculos ativos, provocada pelo aumento dos trancamentos e exclusoes, o que se mostrou de forma mais acentuada nas Ciencias Exatas e da Terra e com os ingressantes de 2016 a 2019. EnglishThis study aimed to think about the effects of the pandemic caused by Covid-19 on the higher education students’ stay at the Federal University of Goias (UFG) In order to answer this question, documentary research was carried out based on primary data relating to the students’ bonding situation in two periods of the first academic semester of 2020, before and after the pandemic, considering both the general scene of the university and the particularities of the university, areas of knowledge, year of entry into the institution and academic degrees. In addition, to support the analysis of the data, the documentary research made use of secondary official documents from the Ministry of Education and the UFG, mainly, but also from the Institute of Applied Economic Research and the National Association of the Directors of the Federal Institutions of University Education. Still, bibliographic research was done, anchored in authors who discuss dropout, student permanence and education in the context of the pandemic. As a result, the study showed that there was a reduction in active bonds, caused by the increase in lockouts and exclusions, which was more pronounced in the Exact and Earth Sciences and with the new entrants from 2016 to 2019 portuguesLa propuesta de este estudio es reflexionar sobre los efectos de la pandemia causada por el Covid-19 en la permanencia de los estudiantes de la educacion superior en la Universidade Federal de Goias, en Brasil. Para responder a esa cuestion se hizo una investigacion documental basada en datos primarios relativos a la situacion de vinculo de los estudiantes en dos periodos de primer semestre lectivo del 2020, antes y a partir de la pandemia, considerando tanto el panorama general de la universidad como las particularidades de las areas do conocimiento, del ano de ingreso en la institucion y de los grados academicos. Ademas, para subvencionar el analisis de los datos la investigacion documental recurrio a documentos oficiales secundarios del Ministerio da Educacao y de la Universidade Federal de Goias, principalmente, pero tambien del Instituto de Pesquisa Economica Aplicada y de la Associacao Nacional dos Dirigentes das Instituicoes Federais de Ensino Superior. Ademas, se hizo la investigacion bibliografica basada en autores que discuten evasion, permanencia estudiantil y educacion en el contexto de la pandemia. Como resultado, el estudio mostro que hubo una reduccion de los vinculos activos, provocada por el aumento de las anulaciones y exclusiones, lo que se mostro de forma mas acentuada en Ciencias Exatas e da Terra y con los alumnos de nuevo ingreso del 2016 al 2019

Published
2021

26. Peri-procedural, 30-day and 1 year-outcomes in chronic dialysis patients undergoing transcatheter aortic valve implantation

Author

F Albuquerque, R Lima, R Campante Teles, D Gomes, P Lopes, A Felix Oliveira, M Goncalves, J Brito, L Raposo, S Leal, H Mesquita Gabriel, P De Araujo Goncalves, M De Sousa Almeida, and M Mendes

Subjects
Cardiology and Cardiovascular Medicine
Abstract

Background Patients on chronic dialysis (CD) due to end-stage renal disease (ESRD) with symptomatic severe aortic stenosis eligible for transcatheter aortic valve implantation (TAVI) were excluded from randomized clinical trials. Our study aimed to investigate the outcomes of patients with chronic dialysis who underwent TAVI. Methods Single center analysis on prospectively collected data of all consecutive patients who underwent TAVI between January 2011 and December 2020 according to baseline renal function: chronic dialysis group (CD) and control group (CTRL). Procedural, 30-day and 1-year outcomes were assessed. Outcomes were defined in accordance with the VARC-3 criteria. Results A total of 875 patients underwent TAVI during the study period, of whom 22 (2.5%) were on chronic dialysis. Patients on CD were younger (median age 80 years, [IQR 73–84] vs 84 years, [IQR 80–87]; p Conclusions Chronic dialysis patients submitted to TAVI had significantly higher rates of short-term life threatening and/or major bleeding, short-term and long-term mortality. Careful selection of patients who would benefit from TAVI among patients with ERDS requiring dialysis is necessary to prevent high rates of postprocedural complications and improve outcomes of this high-risk population. Funding Acknowledgement Type of funding sources: None.

Published
2022
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27. Vascular closure device in TAVI with a dedicated endovascular plug-based device – experience from a high-volume tertiary center

Author

F Albuquerque, D Gomes, P De Araujo Goncalves, P Lopes, M Goncalves, A Felix Oliveira, J Brito, S Leal, L Raposo, H Mesquita Gabriel, R Campante Teles, M De Sousa Almeida, and M Mendes

Subjects
Cardiology and Cardiovascular Medicine
Abstract

Background Vascular complications at the access site are important adverse events during transcatheter aortic valve implantation (TAVI). Effective, reproducible, and safe closure of large bore arteriotomies remains challenging as management strategies vary among centers and operators. MANTAÒ is a dedicated plug-based vascular closure device (VCD) recently approved for percutaneous access site closure. This study aimed to describe our experience and to determine the safety and effectiveness of MANTAÒ for large bore arteriotomies during transfemoral TAVI. Methods Single center retrospective analysis on prospectively collected data of all consecutive patients who underwent transfemoral TAVI from 2018 to 2020. The primary safety outcomes were access-related vascular injury and bleeding complications according to VARC-3 criteria. Technical success was defined as puncture closure obtained with MANTAÒ without the use of unplanned endovascular or surgical intervention. A secondary analysis according to center experience was performed. Results Of the 535 patients that underwent transfemoral TAVI during the study period (median age = 84 [IQR 80–87], 39.4% male; median EuroSCORE II of 3.89% [IQR 2.62–5.39]), MANTAÒ VCD was deployed in 320 (59.8%). Overall, 32 (10.0%) patients suffered an access-related vascular injury and 22 (6.6%) had a bleeding complication (Figure 1A). Technical success was achieved in most cases (n=298; 93.1%). 30-day mortality rate was 1.6% (n=5). Since the first deployment in mid-2018, the rates of MANTA-related complications decreased with increasing experience and a steep learning curve effect was noted (Figure 1B). Conclusions MANTAÒ was rapidly adopted as the default strategy for vascular access site closure after TAVI at our center. A relatively steep learning was observed, suggesting that few procedures are required to acquire device proficiency. In addition, our results suggest that MANTA Ò can effectively close large bore arteriotomies with a low risk of severe complications. Funding Acknowledgement Type of funding sources: None.

Published
2022
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28. Recent improvements and maximum covariance analysis of aerosol and cloud properties in the EC-Earth3-AerChem model

Author

M. A. Thomas, K. Wyser, S. Wang, M. Chatziparaschos, P. Georgakaki, M. Costa-Surós, M. Gonçalves Ageitos, M. Kanakidou, C. P. García-Pando, A. Nenes, T. van Noije, P. Le Sager, and A. Devasthale

Subjects
Geology, QE1-996.5
Abstract

Given the importance of aerosols and clouds and their interactions in the climate system, it is imperative that the global Earth system models accurately represent processes associated with them. This is an important prerequisite if we are to narrow the uncertainties in future climate projections. In practice, this means that continuous model evaluations and improvements grounded in observations are necessary. Numerous studies in the past few decades have shown both the usability and the limitations of utilizing satellite-based observations in understanding and evaluating aerosol–cloud interactions, particularly under varying meteorological and satellite sensor sensitivity paradigms. Furthermore, the vast range of spatio-temporal scales at which aerosol and cloud processes occur adds another dimension to the challenges faced when evaluating climate models. In this context, the aim of this study is two-fold. (1) We evaluate the most recent, significant changes in the representation of aerosol and cloud processes implemented in the EC-Earth3-AerChem model in the framework of the EU project FORCeS compared with its previous CMIP6 version (Coupled Model Intercomparison Project Phase 6; https://pcmdi.llnl.gov/CMIP6/, last access: 13 February 2019). We focus particularly on evaluating cloud physical properties and radiative effects, wherever possible, using a satellite simulator. We report on the overall improvements in the EC-Earth3-AerChem model. In particular, the strong warm bias chronically seen over the Southern Ocean is reduced significantly. (2) A statistical, maximum covariance analysis is carried out between aerosol optical depth (AOD) and cloud droplet (CD) effective radius based on the recent EC-Earth3-AerChem/FORCeS simulation to understand to what extent the Twomey effect can manifest itself in the larger spatio-temporal scales. We focus on the three oceanic low-level cloud regimes that are important due to their strong net cooling effect and where pollution outflow from the nearby continent is simultaneously pervasive. We report that the statistical covariability between AOD and CD effective radius is indeed dominantly visible even at the climate scale when the aerosol amount and composition are favourably preconditioned to allow for aerosol–cloud interactions. Despite this strong covariability, our analysis shows a strong cooling/warming in shortwave cloud radiative effects at the top of the atmosphere in our study regions associated with an increase/decrease in CD effective radius. This cooling/warming can be attributed to the increase/decrease in low cloud fraction, in line with previous observational studies.

Published
2024
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29. DRAPS: A Design Rule Aware Path Search Algorithm for Detailed Routing

Author

Leomar S. da Rosa, Felipe de Souza Marques, and Stephano M. M. Goncalves

Subjects
Router, Area rule, Computer science, 0211 other engineering and technologies, 02 engineering and technology, Fast path, 020202 computer hardware & architecture, Search algorithm, Path (graph theory), 0202 electrical engineering, electronic engineering, information engineering, Path search, State (computer science), Electrical and Electronic Engineering, Routing (electronic design automation), Algorithm, 021106 design practice & management
Abstract

Detailed Routing is one of the most time-consuming steps of physical synthesis of ICs. Also, it is very challenging due to the complexity of the design rules that the router must obey. For some of these rules, if they are handled in a postprocessing step after routing, it may be impossible to avoid design rule violations. This requires that these rules are handled by the path search algorithm used in routing. Thus, we propose DRAPS, a design rule aware path search algorithm. DRAPS is an A*-interval-based fast path search algorithm which is aware of the via library, the minimal area rule and the cut spacing rule of vias belonging to the same path. Our experiments show that DRAPS reduces the design rule violation count by 96% on average, in comparison with a non-design-rule aware path search. Besides, we have compared our detailed routing system to two state-of-the-art academic routers (Dr. CU and TritonRoute) that were tested using ISPD18 benchmarks. Our router has presented, on average, 22% less runtime and 81% less design rule violations w.r.t. Dr. CU, which was the better of the compared routers.

Published
2020
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30. Charge correction formulation on the staircase edges and effective length of inclined wires in FDTD mesh

Author

Tarcísio Carlos Fonseca, Sandro T. M. Goncalves, Glaucio Lopes Ramos, and Cassio G. Rego

Subjects
Electromagnetic field, Physics, Work (thermodynamics), Propagation time, Resistive touchscreen, Acoustics, 020208 electrical & electronic engineering, Finite-difference time-domain method, 020206 networking & telecommunications, Charge (physics), 02 engineering and technology, 0202 electrical engineering, electronic engineering, information engineering, Voltage source, Electrical and Electronic Engineering, Electrical impedance
Abstract

This work presents improvements for inclined thin wire simulation in finite-difference time-domain (FDTD). Modelling of the corners of staircase geometries is proposed by adding the accumulated charges at an edge region. This correction is important due to the delay of the electromagnetic fields propagation on the stairs. To test the validity of the proposition, the v-dipole fed by a resistive voltage source is designed and implemented. A significant improvement can be noted in the calculation of the impedance when the stairs of the geometry are more discretised and the charge correction is applied. Also, a surprising outcome is issued when the stair formed by an inclined thin wire has only one cell per stair: a perfect emulation of an inclined wire happens when the charge correction is applied, showing that a correction of the propagation time of the electromagnetic fields is automatically performed. Based on the propagation time adjustments, an effective length model has also been proposed to emulate the real size of the inclined wire by the size correction of the staircase geometry. Although the effective length depends on the FDTD parameters initial setup, it has a fast response and a low complexity implementation with good accuracy.

Published
2020
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31. Analysis and Optimization of Ultra-Low-Power Rectifier with High Efficiency for Applications in Wireless Power Transmission and Energy Harvesting

Author

Christian Vollaire, Glaucio Lopes Ramos, Raphaella Luiza Resende da Silva, Sandro T. M. Goncalves, Arnaud Bréard, and Cassio G. Rego

Subjects
Optimization, Power transmission, Rectenna, business.industry, Computer science, Direct current, Power Harvest, Electrical engineering, 020206 networking & telecommunications, Topology (electrical circuits), 02 engineering and technology, 01 natural sciences, Power (physics), TK1-9971, Rectifier, 0103 physical sciences, 0202 electrical engineering, electronic engineering, information engineering, Low Power Rectifier, Electrical engineering. Electronics. Nuclear engineering, Electrical and Electronic Engineering, 010306 general physics, business, Energy harvesting, Voltage
Abstract

The system capable of harvesting RF energy from the environment through an antenna and converting it into direct current energy to deliver to a load is known as rectenna. The rectifier circuit is an important part of the rectenna and its modeling is arduous since it employs a non-linear device working at extremely low power levels. In addition, there are some losses in the system. Thus, the design of a high-efficient rectifier is a great challenge. In this work, several rectifier topologies are optimized, using the Genetic Algorithm, in order to achieve the highest efficiency and output voltage. An analysis of the influence of the variables on the output of these rectifiers was also performed. The topologies under investigation were optimized for −15 dBm input power and 2.45 GHz operating frequency, in accordance with the most suitable band for energy harvesting. Under these conditions, the Monodiode Series topology presents the best performance. When the input power is −15 dBm, it presents an output voltage of 402 mV and an efficiency of 51.3%. At that power level, the achieved efficiency is higher than that found in the literature.

Published
2020

32. Case Report: SARS-CoV-2 Gamma Isolation From Placenta of a Miscarriage in Midwest, Brazil

Author

Zoraida Fernandez, Gislene G. C. Lichs, Claudia S. Zubieta, Ana B. Machado, Mia A. Ferreira, Natalia Valente, Thayssa Keren, Ighor Arantes, Valeria Nacife, Elisa Cavalcante Pereira, Luciana Appolinario, Thays E. J. Lacerda, Marilda M. Siqueira, Ana O. P. Esposito, Luiz H. F. Demarchi, Marina C. S. U. Zardin, Crhistinne C. M. Goncalves, Livia M. A. Maziero, Luciana A. F. Miziara, Felipe G. Naveca, Alex Pauvolid-Corrêa, Paola C. Resende, and Alexsandra R. M. Favacho

Subjects
embryonic structures, General Medicine
Abstract

The present study investigated a SARS-CoV-2 infection in placenta and fetal samples from an early pregnancy miscarriage in Midwest Brazil. The Gamma variant was isolated and fully sequenced from the placenta sample, but not from fetal samples. Our findings highlight potential adverse perinatal outcomes caused by SARS-CoV-2 Gamma infection during pregnancy.

Published
2022
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33. Influence of tonotopic cochlear stimulation on subjective visual vertical - a pilot study

Author

M, Goncalves, L, Francois, F, Christov, I, Khouchoua, and M, Westhofen

Subjects
Adult, Aged, 80 and over, Male, Hearing Loss, Sensorineural, Patient Acuity, Pilot Projects, Middle Aged, Electric Stimulation, Cochlear Implants, Visual Perception, Humans, Female, Prospective Studies, Aged
Abstract

This pilot study aimed at evaluating the effect of tonotopic (basal) stimulation on the Subjective Visual Vertical (SVV) in patients unilaterally treated with a Cochlear Implant (CI).Ten adult subjects with severe to profound sensorineural hearing loss, who were implanted with a CI from Advanced Bionics (AB, Stäfa, Switzerland), model HiRes 90KTM or newer, were included in this prospective pilot study between September and December 2020. A specific CI processor (Naída CI Q90) was used to generate five different stimulation modes: simulation of either basal, medial, or apical electrodes, all electrodes on and all electrodes off. The examination of the verticality was carried out by means of SVV goggles both in the upright body position (head position 0 degrees) and with the head tilted sideways (-30°, -15°, +15°, +30°).In each stimulation mode, there was a significant difference (p0.05) in SVV between the straight head orientation and the tilted head position. There were, however, no significant differences between the five CI settings in any given head position (p0.05). No significant differences could be found regarding the direction of SVV deviation relative to the operated ear (p0.05).SVV could not be influenced by tonotopic CI stimulation. Different stimulation settings, patterns and intensity other than the auditory strategy may have to be developed to provide an adequate stimulus to the otolith organs.

Published
2021

34. COVID-19 in Gastroenterology Departments: The Impact of the First Wave

Author

I. Mocanu, M. Goncalves, R. Carvalho, Gastroente Nucleo, T. Leal, and L. Gloria

Subjects
medicine.medical_specialty, Coronavirus disease 2019 (COVID-19), telehealth, Telehealth, RC799-869, Gastroenterology, Fellowship, Internal medicine, Health care, Pandemic, medicine, endoscopy, Personal protective equipment, Internato, General Environmental Science, Response rate (survey), Pandemia, Remote Consultation, business.industry, pandemic, fellowship, COVID-19, Endoscopy, Telemedicina, Diseases of the digestive system. Gastroenterology, language.human_language, covid-19, language, General Earth and Planetary Sciences, Endoscopia, Portuguese, business, Research Article
Abstract

Coronavirus disease 2019 (COVID-19) is a global pandemic that has severely affected health care systems around the world. During the emergency state declared in Portugal in the months of March and April 2020, there was a severe reduction in medical activity in order to reduce the pressure on health systems. This study aimed to assess the impact of COVID-19 in gastroenterology departments across Portugal and the strategies developed to overcome this challenge.This was a cross-sectional study based on an online survey. A detailed questionnaire concerning different aspects of gastroenterology department activity was sent via e-mail to the heads of gastroenterology departments of Portuguese District Hospitals (Núcleo de Gastroenterologia dos Hospitais Distritais). Two periods were assessed, i.e., the emergency state and the recovery period between May and September. The responses were collected between September and October 2020.A total of 21 hospitals were enrolled (80.8% response rate). Twenty-eight percent of the responders reported healthcare professionals from their unit infected with COVID-19. At least 1 member (mostly fellows) of the department was deployed to another workplace in 66.7% of the hospitals. During the emergency state, 47.6% of the hospitals only performed urgent/emergent endoscopic procedures. In 38.5% of the hospitals the need to ration personal protective equipment led to the suspension of endoscopic training. Regarding the recovery period, nonurgent procedures were restarted in almost all of the centers. The same was reported for the colorectal cancer screening program. Remarkably, 81% of the responders confirmed that they had postponed procedures at patients' request for "fear of getting infected." Remote consultation was maintained in 81% of the hospitals. Globally, the fellows had resumed their training.This study provides a snapshot of the impact and consequences of the first wave of the COVID-19 pandemic across Portuguese hospitals. It is important to understand how the gastroenterology world dealt with the first impact of COVID-19 and what strategies were implemented in order to better prepare for what might follow.A doença por coronavirus 19 (COVID-19) é uma pandemia global que afetou gravemente os serviços de saúde em todo o mundo. Durante o estado de emergência declarado em Portugal nos meses de Março e Abril de 2020, verificou-se uma redução importante na atividade médica. Este estudo teve como objetivo avaliar o impacto da COVID-19 nos Serviços de Gastroenterologia portugueses e as estratégias implementadas para fazer face a este desafio.Tratou-se de um estudo transversal baseado num inquéritoResponderam 21 Hospitais (taxa de resposta: 80,8%). Vinte e oito porcento dos inquiridos tiveram profissionais da sua unidade infectados com COVID-19. Pelo menos um elemento foi mobilizado para outro local de trabalho em 66,7% dos hospitais, maioritariamente internos de formação específica de Gastroenterologia. Durante o estado de emergência, 47,6% dos Hospitais só realizaram endoscopias urgentes/emergentes. Em 38,5%, a necessidade de racionamento de equipamento de proteção individual levou à suspensão do treino em endoscopia. Relativamente ao período de recuperação, os procedimientos não urgentes foram retomados na maioria dos centros. O mesmo se verificou para o programa de rastreio do cancro colorectal. Salienta-se que 81% dos inquiridos confirmaram que adiaram exames a pedido dos doentes por “medo de ficarem infetados”. Mantiveram-se consultas nãopresenciais em 81% dos Hospitais. De modo geral, as atividades de formação dos internos foram progressivamente retomadas.Este estudo oferece o retrato do impacto e consequências da primeira vaga da pandemia nos Hospitais portugueses. É importante compreender como os Serviços de Gastrenterologia nacionais lidaram com o primeiro impacto da COVID-19 e que estratégias foram implementadas de forma a melhor preparar o que se segue.

Published
2021

35. Abstract 10302: A Case for Ending Rifampicin Use in Endocarditis

Author

Jose P Sousa, Carolina N Lourenco, Rogerio Teixeira, and Lino M Goncalves

Subjects
Physiology (medical), Cardiology and Cardiovascular Medicine
Abstract

Background: Rifampicin has been employed in various endocarditis antibiotic regimens, particularly in prosthetic, staphylococcus aureus (SA) and culture-negative cases. However, this practice is not without controversy. Purpose: To perform a meta-analysis aimed at ascertaining the efficacy and safety of adjunctive rifampicin use in endocarditis. Methods: We systematically searched MEDLINE, Embase, Web of Science, Cochrane Library and Google Scholar, from inception to June 1st, 2021, for studies comparing rifampicin-containing antibiotic regimens with those comprising no rifamycin derivatives, in the setting of endocarditis. The primary endpoint was all-cause death, while relapse, bail-out valvular surgery, microbiological failure (lasting positivity of blood cultures) and hepatotoxicity (fivefold or higher increase in transaminase levels) were secondary outcomes. SA infections were investigated separately, with respect to the primary endpoint. Mantel-Haenszel odds ratios (ORs) were pooled using traditional meta-analytic techniques, under a random-effects model. Results: 2 randomized, 1 non-randomized prospective and 6 retrospective studies, featuring 886 patients (of whom 322 allocated to rifampicin), were included. While 8 studies addressed staphylococcal endocarditis (with 3 of them dealing exclusively with SA infections), prosthetic and culture-negative cases were only focused on 1 study each. There were 96 deaths (from 7 studies), 32 relapses (from 6 studies), 35 bail-out valvular surgeries (from 4 studies), 14 microbiological failures (from 2 studies) and 32 hepatotoxicity cases (from 5 studies). Rifampicin use was associated with a tendency towards higher all-cause mortality (OR 1.63, 95% CI 0.85-3.12, P 0.14, i 2 12%), which held true for SA infections (OR 1.63, 95% CI 0.67-3.92, P 0.28, i 2 20%), and bail-out valve surgery (OR 2.03, 95% CI 0.65-6.34, P 0.22, i 2 5%). Relapse and microbiological failures rates were similar between groups (OR 1.25, 95% CI 0.59-2.65, P 0.56, i 2 0% and OR 1.3, 95% CI 0.24-6.90, P 0.76, i 2 41%, respectively). Hepatotoxicity odds were greater in the rifampicin arm (OR 3.24, 95% CI 1.35-7.77, P 0.008, i 2 0%). Conclusion: Currently available evidence does not support rifampicin use in endocarditis.

Published
2021
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36. Modeling impacts of dust mineralogy on fast climate response

Author

Q. Song, P. Ginoux, M. Gonçalves Ageitos, R. L. Miller, V. Obiso, and C. Pérez García-Pando

Subjects
Physics, QC1-999, Chemistry, QD1-999
Abstract

Mineralogical composition drives dust impacts on Earth's climate systems. However, most climate models still use homogeneous dust, without accounting for the temporal and spatial variation in mineralogy. To quantify the radiative impact of resolving dust mineralogy on Earth's climate, we implement and simulate the distribution of dust minerals (i.e., illite, kaolinite, smectite, hematite, calcite, feldspar, quartz, and gypsum) from Claquin et al. (1999) (C1999) and activate their interaction with radiation in the GFDL AM4.0 model. Resolving mineralogy reduces dust absorption compared to the homogeneous dust used in the standard GFDL AM4.0 model that assumes a globally uniform hematite volume content of 2.7 % (HD27). The reduction in dust absorption results in improved agreement with observation-based single-scattering albedo (SSA), radiative fluxes from CERES (the Clouds and the Earth's Radiant Energy System), and land surface temperature from the CRU (Climatic Research Unit) compared to the baseline HD27 model version. It also results in distinct radiative impacts on Earth's climate over North Africa. Over the 19-year (from 2001 to 2019) modeled period during JJA (June–July–August), the reduction in dust absorption in AM4.0 leads to a reduction of over 50 % in net downward radiation across the Sahara and approximately 20 % over the Sahel at the top of the atmosphere (TOA) compared to the baseline HD27 model version. The reduced dust absorption weakens the atmospheric warming effect of dust aerosols and leads to an alteration in land surface temperature, resulting in a decrease of 0.66 K over the Sahara and an increase of 0.7 K over the Sahel. The less warming in the atmosphere suppresses ascent and weakens the monsoon inflow from the Gulf of Guinea. This brings less moisture to the Sahel, which combined with decreased ascent induces a reduction of precipitation. To isolate the effect of reduced absorption compared to resolving spatial and temporal mineralogy, we carry out a simulation where the hematite volume content of homogeneous dust is reduced from 2.7 % to 0.9 % (HD09). The dust absorption (e.g., single-scattering albedo) of HD09 is comparable to that of the mineralogically speciated model on a global mean scale, albeit with a lower spatial variation that arises solely from particle size. Comparison of the two models indicates that the spatial inhomogeneity in dust absorption resulting from resolving mineralogy does not have significant impacts on Earth's radiation and climate, provided there is a similar level of dust absorption on a global mean scale before and after resolving dust mineralogy. However, uncertainties related to emission and distribution of minerals may blur the advantages of resolving minerals to study their impact on radiation, cloud properties, ocean biogeochemistry, air quality, and photochemistry. On the other hand, lumping together clay minerals (i.e., illite, kaolinite, and smectite), but excluding externally mixed hematite and gypsum, appears to provide both computational efficiency and relative accuracy. Nevertheless, for specific research, it may be necessary to fully resolve mineralogy to achieve accuracy.

Published
2024
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37. Observationally constrained regional variations of shortwave absorption by iron oxides emphasize the cooling effect of dust

Author

V. Obiso, M. Gonçalves Ageitos, C. Pérez García-Pando, J. P. Perlwitz, G. L. Schuster, S. E. Bauer, C. Di Biagio, P. Formenti, K. Tsigaridis, and R. L. Miller

Subjects
Physics, QC1-999, Chemistry, QD1-999
Abstract

The composition of soil dust aerosols derives from the mineral abundances in the parent soils that vary across dust source regions. Nonetheless, Earth system models (ESMs) have traditionally represented mineral dust as a globally homogeneous species. The growing interest in modeling dust mineralogy, facilitated by the recognized sensitivity of the dust climate impacts to composition, has motivated state-of-the-art ESMs to incorporate the mineral speciation of dust along with its effect upon the dust direct radiative effect (DRE). In this work, we enable the NASA Goddard Institute for Space Studies ModelE2.1 to calculate the shortwave (SW) DRE accounting for the regionally varying soil mineralogy. Mineral–radiation interaction at solar wavelengths is calculated according to two alternative coupling schemes: (1) external mixing of three mineral components that are optically distinguished, one of which contains embedded iron oxides; (2) a single internal mixture of all dust minerals with a dynamic fraction of iron oxides that varies regionally and temporally. We link dust absorption to the fractional mass of iron oxides based on recent chamber measurements using natural dust aerosol samples. We show that coupled mineralogy overall enhances the scattering by dust, and thus the global cooling, compared to our control run with globally uniform composition. According to the external mixing scheme, the SW DRE at the top of atmosphere (TOA) changes from −0.25 to -0.30Wm-2, corresponding to a change in the net DRE, including the longwave effect, from −0.08 to -0.12Wm-2. The cooling increase is accentuated when the internal mixing scheme is configured: the SW DRE at the TOA becomes -0.34Wm-2 with a net DRE of -0.15Wm-2. The varying composition modifies the regional distribution of single scattering albedo (SSA), whose variations in specific regions can be remarkable (above 0.03) and significantly modify the regional SW DRE. Evaluation against the AErosol RObotic NETwork (AERONET) shows that explicit representation of soil mineralogy and its regional variations reduces the low bias of model dust SSA while improving the range of variability across stations and calendar months. Despite these improvements, the moderate spatiotemporal correlation with AERONET reveals remaining modeling challenges and the need for more accurate measurements of mineral fractions in soils.

Published
2024
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38. Feasibility of coronary angiography after TAVR

Author

Aurora Rodrigues, L Santos, P Ribeiro Queiros, Patrícia Aparecida de Campos Braga, Ricardo Fontes-Carvalho, M Ribeiro Da Silva, Gustavo Pires-Morais, Bruno Melica, C Espada Guerreiro, Guida Silva, P M Goncalves Teixeira, F. Sampaio, Dylan Ferreira, and M Brandao

Subjects
Coronary angiography, medicine.medical_specialty, business.industry, Internal medicine, Cardiology, Medicine, Cardiology and Cardiovascular Medicine, business
Abstract

Background The prevalence of coronary artery disease (CAD) is high among patients with severe aortic stenosis who undergo transcatheter aortic valve replacement (TAVR). Indications for TAVR are now expanding to younger and lower risk patients. During their lifetime, these patients will be at risk of developing CAD and it is expected an increase in coronary angiography and percutaneous coronary intervention (PCI). Aortic prosthesis, particularly if in supra-annular position, may pose important technical difficulties in coronary re-engagement after TAVR. Purpose To evaluate the feasibility to reengage the coronary ostia after TAVR, describe complications and compare technical differences between coronary procedures performed before and after TAVR. Methods Retrospective analysis of 714 patients submitted to TAVR from August 2007 to December 2019. Patients who needed coronary angiography after TAVR were selected. The primary endpoint was the rate of successful coronary ostia cannulation after TAVR, defined by the possibility to selectively cannulate and inject both coronary ostia. Secondary endpoint was complications associated with coronary catheterization after TAVR. Results Among 714 patients, 25 (3.5%) patients were submitted to a total of 28 coronary angiography after TAVR. 14 patients were male (56%), mean age 78.2±6.2 years and 9 (36%) had history of previous coronary revascularization. From the 28 coronary angiographies (balloon-expandable Edwards-Sapien n=11, 44%; self-expandable CoreValve n=10, 40%; Portico n=2, 8%; Symetis n=2, 8%), 25 (89%) met the primary endpoint. Only three was semiselective (Symetis, CoreValve Evolut R and CoreValve TAVR in TAVR), with impossibility to cannulate both coronary arteries, right coronary artery and left coronary artery, respectively. 13 (46%) patients had also indication for PCI and all were successfully performed (Edwards-Sapien n=4, 31%; CoreValve n=6, 46%; Portico n=2, 15%; Symetis n=1, 8%). The main indications for coronary angiography was chronic coronary syndrome (n=12, 43%) and acute coronary syndrome without ST segment elevation (n=7, 25%). Circumflex artery was the most frequently treated vessel (n=6), followed by left anterior descending artery (n=4), right coronary artery (n=3) and left main (n=2). There were no complications reported during or post-procedure. Comparing coronary angiographies before and after TAVR, there were no significant differences regarding arterial access site, catheter diameter, fluoroscopy time and quantity of contrast used in coronary angiography. Conclusion Although the need for coronary angiography was rare in patients after TAVR, selective diagnostic coronary angiographies were possible in 89% (25/28) and PCI was feasible in all patients in whom it was indicated, without any reported complications. Further prospective studies are needed to confirm the great feasibility of performing coronary angiography after TAVR. Funding Acknowledgement Type of funding sources: Public hospital(s). Main funding source(s): Centro Hospitalar Vila Nova de Gaia / Espinho

Published
2021
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39. Staging cardiac damage in aortic valve disease: one size fits all?

Author

P Ribeiro Queiros, Guida Silva, C Espada Guerreiro, M Brandao, Ricardo Fontes-Carvalho, F. Sampaio, M Ribeiro Da Silva, P M Goncalves Teixeira, and Dylan Ferreira

Subjects
Aortic valve disease, medicine.medical_specialty, business.industry, Internal medicine, cardiovascular system, Cardiology, Medicine, Cardiology and Cardiovascular Medicine, business
Abstract

Background Nowadays, in patients with aortic regurgitation (AR), aortic valve surgery is indicated when severe and symptomatic or those with depressed LVEF. However, clinical outcomes of patients with significant aortic regurgitation are not influenced by these factors only. Recently, a new staging system for severe aortic stenosis has been proposed by Généreux on the basis of the extent of anatomic and functional cardiac damage. If this model could be applicable to an unselected significant AR population has not been tested. Purpose The aim of our study was to evaluate the prevalence of the different stages of extra-aortic valvular cardiac damage by the application of Généreux staging and its impact on prognosis in a large, real world cohort of significant AR patients. Methods This study retrospectively analysed the clinical, Doppler echocardiographic and outcome data in patients with grade III or greater AR between January 2014 and September 2019. According to the extent of cardiac damage on echocardiography, patients were classified as Stage 0 (no cardiac damage), Stage 1 (left ventricular damage), Stage 2 (mitral valve or left atrial damage), Stage 3 (tricuspid valve or pulmonary artery vasculature damage) or Stage 4 (right ventricular damage). Exclusion criteria were severe aortic stenosis and previous valve repair or replacement. The primary end-point was all-cause mortality. Results A total of 572 patients, aged 70.1±13.9 years, 294 (51.3%) men were enrolled. One third of patients were in NYHA I. Based on the proposed classification, 82 patients (14.3%) were classified in stage 0, 130 (22.7%) in stage 1, 276 (48.2%) in stage 2, 68 (11.8%) in stage 3 and 17 (3.0%) in stage 4. Median follow-up time was 3.3±1.9 years. There was a progressive increase in mortality rates according to staging: 8.5% in stage 0, 10.8% in stage 1, 24.9% in stage 2, 42.6% in stage 3 and 52.9% in stage 4 (p Conclusion Our study demonstrated that this new staging system studied for aortic stenosis also provides increased prognostic value to patients with significant aortic regurgitation. This staging system can be helpful to identify the degree of extra-aortic valvular cardiac damage and to optimize the time of valvular intervention. Further prospective studies are needed to confirm the benefit of the applicability of this model in clinical practice. Funding Acknowledgement Type of funding sources: Public hospital(s). Main funding source(s): Centro Hospitalar Vila Nova de Gaia / Espinho Distribution of stages of cardiac damageSurvival analysis according to stage

Published
2021
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40. Long-term durability of transcatheter aortic valve replacement: outcomes from a contemporary cohort from a tertiary reference center at 5-years and beyond

Author

Margarida Madeira, M Sousa Almeida, G Sa Mendes, Unicarv, Luís Raposo, M Mendes, R Campante Teles, Tiago Nolasco, A Felix Oliveira, Petronio Lopes, J Brito, M Goncalves, João Abecasis, and P Araujo Goncalves

Subjects
medicine.medical_specialty, Valve replacement, Transcatheter aortic, business.industry, Long term durability, medicine.medical_treatment, Cohort, Medicine, Center (algebra and category theory), Cardiology and Cardiovascular Medicine, business, Surgery
Abstract

Background and aim Long-term data on the durability of transcatheter heart valves is scarce. This is of particular interest as indications expand to younger and lower surgical risk patients. We sought to assess the incidence of long-term structural valve dysfunction (SVD) and bioprosthetic valve failure (BVF) in a cohort of patients with TAVR who reached at least 5-year follow-up, as compared to surgical aortic valve replacement (SAVR), performed within the same time-frame at the same institution. Methods and results Consecutive patients with at least 5-year available follow-up, who underwent TAVR between November 2008 to December 2015 in a tertiary single center, were included. From a group of 246 patients undergoing TAVR, 126 had available follow-up data (age at implantation: 83.0 [77.8–87.0] years; EuroScore II: 4.54 [2.60–6.29]%; follow-up: 5.94 [5.06–7.67] years). First generation Corevalve® and Sapien® prosthesis were implanted in 56% and 38% patients, respectively. SVD and BVF were defined according to the new consensus statement from the EAPCI endorsed by the ESC and the EACTS. Mean transaortic pressure gradients decreased from 53.2±1.3 mmHg (pre-TAVR) to 10.4±0.4 mmHg (at discharge or up to one-year after TAVR, p As comparator, from a cohort of 587 patients submitted to biological SAVR, 247 (age 75.0 [70.0–79.0] years; EuroScore II 1.43 [1.06–2.17]%) had available long-term follow-up (6.89 [6.08–8.19] years). Moderate and severe SVD were reported in 42 and 3 patients, respectively (8-year cumulative incidence function to SVD: 3.13%; 95% CI, 2.45–4.21). These events were clinically relevant (BVF) in 19 of them: 8 performed TAVR valve-in-valve procedures and 3 redo SAVR. At the fifth-year of follow-up the incidence of SVD was not statistically different between TAVR (8%) and SAVR (15%), with a p for comparison of 0.137. Conclusions In our population of patients with symptomatic severe aortic stenosis treated with first-generation percutaneous bioprostheses, TAVR was associated with a low incidence of BVF and SVD at the long-term follow-up. These outcomes seem indistinct from those occurring in patients submitted to conventional SAVR Funding Acknowledgement Type of funding sources: None. KM curve reporting probability of SVD

Published
2021
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41. Mesenchymal stem cell secretome decreases the inflammatory response in annulus fibrosus organ cultures

Author

C, Neidlinger-Wilke, A, Ekkerlein, R M, Goncalves, J R, Ferreira, A, Ignatius, H J, Wilke, and G Q, Teixeira

Subjects
Organ Culture Techniques, Annulus Fibrosus, Animals, Cattle, Mesenchymal Stem Cells, Cells, Cultured, Secretome
Abstract

Mesenchymal stem/stromal cell (MSC)-based therapies have been proposed for back pain and disc degeneration, despite limited knowledge on their mechanism of action. The impact of MSCs/their secretome on annulus fibrosus (AF) cells and tissue was analysed in bovine AF organ cultures (AF-OCs) exposed to upper-physiological cyclic tensile strain (CTS, 9 %, 1 Hz, 3 h/d) and interleukin (IL)-1β in a custom-made device. A 4 d treatment of the CTS + IL-1β-stimulated AF-OCs with MSC secretome downregulated the expression of inflammation markers [IL-6, IL-8, prostaglandin-endoperoxide synthase 2 (PTGS2)], complement system regulators [cluster of differentiation (CD)46, CD55, CD59] and matrix metalloproteinase 1 but also of tissue inhibitors of metalloproteinases (TIMP-1, TIMP-2) and collagen type I. At the protein level, it was confirmed that IL-6, MMP-3 and collagen content was decreased in AF-OCs treated with the MSC secretome compared to the CTS + IL-1β stimulation alone. 9 d after treatment, a biomechanical peel-force test showed that the annular adhesive strength was significantly decreased by the MSC secretome treatment. Overall, MSC secretome had a stronger impact on AF tissue than MSCs in co-culture. The secretome contributed to a decrease in the inflammatory and catabolic status of AF cells activated by CTS + IL-1β and played a role in the regulation of the complement system. However, it also contributed to a decrease in collagen at the gene/protein level and in AF mechanical strength compared to the CTS + IL-1β stimulation alone. Therefore, the use of MSC secretome requires further investigation regarding its influence on disc matrix properties.

Published
2021

42. Patients undergoing invasive coronary angiography after a positive single-photon emission computed tomography or a positive stress cardiac magnetic resonance - What to expect at the cath lab

Author

J Brito, A M Ferreira, Henrique Mesquita Gabriel, Carla Saraiva, PN Freitas, C. Silva, M Almeida, S Guerreiro, M Goncalves, Pedro de Araújo Gonçalves, Luís Raposo, A Ventosa, Petronio Lopes, J Calqueiro, and João Abecasis

Subjects
medicine.medical_specialty, Cath lab, medicine.diagnostic_test, business.industry, medicine.medical_treatment, Ischemia, Coronary arteriosclerosis, General Medicine, Cardiac catheterization lab, Single-photon emission computed tomography, medicine.disease, Revascularization, Invasive coronary angiography, Internal medicine, Cardiology, Medicine, Radiology, Nuclear Medicine and imaging, Cardiology and Cardiovascular Medicine, business, Cardiac magnetic resonance
Abstract

Funding Acknowledgements Type of funding sources: None. Background Randomized controlled trials comparing stress cardiac magnetic resonance (CMR) and single-photon emission computed tomography (SPECT) suggest similar diagnostic accuracy for detecting obstructive coronary artery disease (CAD). However, there are few data on whether or not this remains true in routine clinical practice. The aim of this study was to assess the clinical and angiographic characteristics of patients undergoing invasive coronary angiography (ICA) after a positive stress CMR or positive SPECT, and to compare their positive predictive value with published results from the CE-MARC trial. Methods In this retrospective tertiary-center analysis, we included 429 patients (mean age 67 ± 10 years, 28% women, 42% diabetic) undergoing ICA between January 2016 and December 2020, after a positive stress CMR or positive SPECT. Regarding stress test, an adenosine protocol was performed in all stress CMR and in 76.4% (n = 272) of stress SPECT. Stress test results, including ischemia location and severity, were classified as reported by their primary readers. Patients with missing data on key variables, and those in whom microvascular disease was considered likely in the original stress test report were excluded. Obstructive CAD was defined as any coronary artery stenosis ≥ 50% in a vessel compatible with the ischemic territory on stress testing. Results Out of the total 429 patients, 356 (83%) were referred after a positive SPECT, and 73 (17%) after a positive stress CMR. Patients did not differ regarding age, cardiovascular risk factors, previous revascularization or left ventricular dysfunction, but patients with SPECT were more frequently male (p = 0.046). Overall, 320 patients (75%) had obstructive CAD on ICA. The prevalence of obstructive CAD was similar in patients with positive SPECT vs. positive stress CMR (76.1% vs. 80.8%, respectively, p = 0.385). There were also no significant differences in the prevalence of left main or 3-vessel disease (9.0% vs. 9.6%, p = 0.871, and 19.7% vs. 23.3% p = 0.483, respectively). Revascularization was performed or planned in 59.3% of patients in the SPECT group, and 52.1% of those in the stress CMR group (p = 0.255). The positive predictive values of both techniques were similar to those reported in the CE-MARC trial (Figure), and would increase to 88.1% and 89.4% for SPECT and stress CMR, respectively, if patients reported as having only mild ischemia were excluded. Conclusion In this tertiary center analysis, stress CMR and SPECT showed similar positive predictive values, comparable to those reported in the CE-MARC trial.

Published
2021
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43. The current value of quantitative shear wave sonoelastography in parotid gland tumors

Author

Mirco Schapher, Konstantinos Mantsopoulos, Michael Koch, M Goncalves, Joachim Hornung, Vivian Thimsen, and Heinrich Iro

Subjects
medicine.diagnostic_test, business.industry, Ultrasound, Sonoelastography, Magnetic resonance imaging, Computed tomography, Parotid gland, medicine.anatomical_structure, Salivary gland tumor, medicine, Surgery, Original Article, business, Nuclear medicine, Clinical treatment
Abstract

Background The preoperative differentiation between salivary gland tumor entities using computed tomography, magnetic resonance imaging (MRI) and ultrasound (US) is still limited. Biopsies are often regarded as indispensable for properly characterizing these various lesions. The aim of this study was to analyze the value of acoustic radiation force impulse (ARFI) sonoelastography as an US differentiation tool when examining parotid gland (PG) lesions. Methods We included 104 patients with PG masses in this study, employing two different US devices using quantitative ARFI-sonoelastography (Siemens Acuson-S3000, n=59; Siemens Acuson-Sequoia, n=45). The ability of sonoelastographic measurements to differentiate between different neoplasms was compared and analyzed for both US machines. Results Quantitative shear wave sonoelastography is limited in its ability to reliably differentiate between tumor entities of the PG as a stand-alone parameter. Measurement results were unsystematically distributed and not transferable between the two US devices. A significant differentiation of benign and malignant lesions was not possible with either US machine (S3000: P=0.770, Sequoia: P=0.382). A differentiation between pleomorphic adenomas (PA) and Warthin tumors was only possible with the Acuson S3000 system (P=0.001, Spearman-Rho =0.492, sensitivity 73.9%, specificity 65.0%). Conclusions A reliable identification and differentiation of PG tumors as well as clinical treatment decisions cannot be made with the sole use of ARFI-sonoelastography. The results emphasize the device-dependence and high error-proneness of this US technique when examining lesions of the PG.

Published
2021

48. Robust Immune Response Induced by

Author

Mayra M F, Barbosa, Alex I, Kanno, Giovana C, Barazzone, Dunia, Rodriguez, Violeta, Pancakova, Monalisa, Trentini, Eliana L, Faquim-Mauro, Amanda P, Freitas, Mariana I, Khouri, Jessica, Lobo-Silva, Viviane M, Goncalves, Rocilda P F, Schenkman, Martha M, Tanizaki, Diana, Boraschi, Richard, Malley, Leonardo P, Farias, and Luciana C C, Leite

Subjects
biotin-avidin coupling, TSP-2 antigen, nanoparticle, Immunity, Schistosoma mansoni, OMV, Mice, Inbred C57BL, Mice, Bacterial Outer Membrane, vaccine, Escherichia coli, Animals, outer membrane vesicles, Original Research
Abstract

Purpose The use of adjuvants can significantly strengthen a vaccine’s efficacy. We sought to explore the immunization efficacy of bacterial outer membrane vesicles (OMVs) displaying the Schistosoma mansoni antigen, SmTSP-2, through a biotin-rhizavidin coupling approach. The rationale is to exploit the nanoparticulate structure and the adjuvant properties of OMVs to induce a robust antigen-specific immune response, in light of developing new vaccines against S. mansoni. Materials and Methods OMVs were obtained from Neisseria lactamica and conjugated with biotin. The recombinant SmTSP-2 in fusion with the biotin-binding protein rhizavidin (rRzvSmTSP-2) was produced in E. coli and coupled to biotinylated OMVs to generate an OMV complex displaying SmTSP-2 on the membrane surface (OMV:rSmTSP-2). Transmission electron microscopy (TEM) and dynamic light scattering analysis were used to determine particle charge and size. The immunogenicity of the vaccine complex was evaluated in C57BL/6 mice. Results The rRzvSmTSP-2 protein was successfully coupled to biotinylated OMVs and purified by size-exclusion chromatography. The OMV:rSmTSP-2 nanoparticles showed an average size of 200 nm, with zeta potential around – 28 mV. Mouse Bone Marrow Dendritic Cells were activated by the nanoparticles as determined by increased expression of the co-stimulatory molecules CD40 and CD86, and the proinflammatory cytokines (TNF-α, IL-6 and IL-12) or IL-10. Splenocytes of mice immunized with OMV:rSmTSP-2 nanoparticles reacted to an in vitro challenge with SmTSP-2 with an increased production of IL-6, IL-10 and IL-17 and displayed a higher number of CD4+ and CD8+ T lymphocytes expressing IFN-γ, IL-4 and IL-2, compared to mice immunized with the antigen alone. Immunization of mice with OMV:rSmTSP-2 induced a 100-fold increase in specific anti-SmTSP-2 IgG antibody titers, as compared to the group receiving the recombinant rSmTSP-2 protein alone or even co-administered with unconjugated OMV. Conclusion Our results demonstrate that the SmTSP-2 antigen coupled with OMVs is highly immunogenic in mice, supporting the potential effectiveness of this platform for improved antigen delivery in novel vaccine strategies.

Published
2021

49. Temporal evolution of sulfadoxine-pyrimethamine resistance genotypes and genetic diversity in response to a decade of increased interventions against Plasmodium falciparum in northern Ghana

Author

Lucas Amenga-Etego, Dominic P. Kwiatkowski, Victor Asoala, Christopher Jacob, Gordon A. Awandare, Godfred Agongo, Kirk A. Rockett, and Sonia M. Goncalves

Subjects
Male, Veterinary medicine, Pfdhps, Drug Resistance, Drug resistance, Ghana, 0302 clinical medicine, Genotype, Haplotype, SP resistance, 030212 general & internal medicine, Malaria, Falciparum, Child, biology, 3. Good health, Drug Combinations, Infectious Diseases, Pyrimethamine, Child, Preschool, Female, Seasons, medicine.drug, lcsh:Arctic medicine. Tropical medicine, Adolescent, lcsh:RC955-962, 030231 tropical medicine, Genotypes, Plasmodium falciparum, Pfdhfr, Amodiaquine, Temporal, lcsh:Infectious and parasitic diseases, 03 medical and health sciences, Antimalarials, Young Adult, parasitic diseases, Sulfadoxine, medicine, Humans, lcsh:RC109-216, Research, Genetic Variation, biology.organism_classification, medicine.disease, Sulfadoxine/pyrimethamine, Malaria, Parasitology
Abstract

Background Anti-malarial drug resistance remains a key concern for the global fight against malaria. In Ghana sulfadoxine-pyrimethamine (SP) is used for intermittent preventive treatment of malaria in pregnancy and combined with amodiaquine for Seasonal Malaria Chemoprevention (SMC) during the high malaria season. Thus, surveillance of molecular markers of SP resistance is important to guide decision-making for these interventions in Ghana. Methods A total of 4469 samples from uncomplicated malaria patients collected from 2009 to 2018 was submitted to the Wellcome Trust Sanger Institute, UK for DNA sequencing using MiSeq. Genotypes were successfully translated into haplotypes in 2694 and 846 mono infections respectively for pfdhfr and pfdhps genes and the combined pfhdfr/pfdhps genes across all years. Results At the pfdhfr locus, a consistently high (> 60%) prevalence of parasites carrying triple mutants (IRNI) were detected from 2009 to 2018. Two double mutant haplotypes (NRNI and ICNI) were found, with haplotype NRNI having a much higher prevalence (average 13.8%) than ICNI (average 3.2%) across all years. Six pfdhps haplotypes were detected. Of these, prevalence of five fluctuated in a downward trend over time from 2009 to 2018, except a pfdhps double mutant (AGKAA), which increased consistently from 2.5% in 2009 to 78.2% in 2018. Across both genes, pfdhfr/pfdhps combined triple (NRNI + AAKAA) mutants were only detected in 2009, 2014, 2015 and 2018, prevalence of which fluctuated between 3.5 and 5.5%. The combined quadruple (IRNI + AAKAA) genotype increased in prevalence from 19.3% in 2009 to 87.5% in 2011 before fluctuating downwards to 19.6% in 2018 with an average prevalence of 37.4% within the nine years. Prevalence of parasites carrying the quintuple (IRNI + AGKAA or SGEAA) mutant haplotypes, which are highly refractory to SP increased over time from 14.0% in 2009 to 89.0% in 2016 before decreasing to 78.9 and 76.6% in 2017 and 2018 respectively. Though quintuple mutants are rising in prevalence in both malaria seasons, together these combined genotypes vary significantly within season but not between seasons. Conclusions Despite high prevalence of pfdhfr triple mutants and combined pfdhfr/pfdhps quadruple and quintuple mutants in this setting SP may still be efficacious. These findings are significant as they highlight the need to continuously monitor SP resistance, particularly using deep targeted sequencing to ascertain changing resistance patterns.

Published
2021

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