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Brain function and clinical characterization in the Boston adolescent neuroimaging of depression and anxiety study

Authors :
N.A. Hubbard
V. Siless
I.R. Frosch
M. Goncalves
N. Lo
J. Wang
C.C.C. Bauer
K. Conroy
E. Cosby
A. Hay
R. Jones
M. Pinaire
F. Vaz De Souza
G. Vergara
S. Ghosh
A. Henin
D.R. Hirshfeld-Becker
S.G. Hofmann
I.M. Rosso
R.P. Auerbach
D.A. Pizzagalli
A. Yendiki
J.D.E. Gabrieli
S. Whitfield-Gabrieli
Source :
NeuroImage: Clinical, Vol 27, Iss , Pp 102240- (2020)
Publication Year :
2020
Publisher :
Elsevier, 2020.

Abstract

We present a Human Connectome Project study tailored toward adolescent anxiety and depression. This study is one of the first studies of the Connectomes Related to Human Diseases initiative and is collecting structural, functional, and diffusion-weighted brain imaging data from up to 225 adolescents (ages 14–17 years), 150 of whom are expected to have a current diagnosis of an anxiety and/or depressive disorder. Comprehensive clinical and neuropsychological evaluations and longitudinal clinical data are also being collected. This article provides an overview of task functional magnetic resonance imaging (fMRI) protocols and preliminary findings (N = 140), as well as clinical and neuropsychological characterization of adolescents. Data collection is ongoing for an additional 85 adolescents, most of whom are expected to have a diagnosis of an anxiety and/or depressive disorder. Data from the first 140 adolescents are projected for public release through the National Institutes of Health Data Archive (NDA) with the timing of this manuscript. All other data will be made publicly-available through the NDA at regularly scheduled intervals. This article is intended to serve as an introduction to this project as well as a reference for those seeking to clinical, neurocognitive, and task fMRI data from this public resource.

Details

Language :
English
ISSN :
22131582
Volume :
27
Issue :
102240-
Database :
Directory of Open Access Journals
Journal :
NeuroImage: Clinical
Publication Type :
Academic Journal
Accession number :
edsdoj.76d428d5cd7c495cb02c23063fb17e7e
Document Type :
article
Full Text :
https://doi.org/10.1016/j.nicl.2020.102240