Search

The purpose of this article is to conceptualize a novel theoretical occurrence—team physical activity (PA)—and its relevance for researchers and organizations. By building a testable model of the consequences and contingencies of team PA, we integrate the science of teamwork with the scholarly domain of employee health and well-being. Hence, we clarify the construct of team PA, present a three-dimensional typology, and outline a model drawing on neuroscience, positive organizational behavior, and teams research. Our propositions and subsequent discussion proffer an outline of potential benefits for organizations when they increase the utility and frequency of team PA. We also suggest ways in which researchers can advance scholarship in this area.

This conceptual paper suggests that the distinction between an autocratic and democratic leadership orientation may serve as an important moderator of the relationship between key organizational characteristics and workplace bullying. More specifically, we explore leader autocratic vs. democratic power orientations and leader agentic vs. communal orientations as the theoretical bases for developing a new model of perceived leadership orientation as a moderator of the relationships between certain key organizational characteristics and perceptions of workplace bullying behavior. Our model proposes differential moderating effects for both leader autocratic-democratic power orientation and leader agentic-communal orientation. Particularly, we contend that democratic and communal leadership orientations may lead to fewer perceptions of bullying in the workplace. We conclude with a discussion of our model’s practical implications and suggestions for future research on this subject.

We have previously designed a library of lentiviral vectors to generate somatic-transgenic rodents to monitor signalling pathways in diseased organs using whole-body bioluminescence imaging, in conscious, freely moving rodents. We have now expanded this technology to adeno-associated viral vectors. We first explored bio-distribution by assessing GFP expression after neonatal intravenous delivery of AAV8. We observed widespread gene expression in, central and peripheral nervous system, liver, kidney and skeletal muscle. Next, we selected a constitutive SFFV promoter and NFκB binding sequence for bioluminescence and biosensor evaluation. An intravenous injection of AAV8 containing firefly luciferase and eGFP under transcriptional control of either element resulted in strong and persistent widespread luciferase expression. A single dose of LPS-induced a 10-fold increase in luciferase expression in AAV8-NFκB mice and immunohistochemistry revealed GFP expression in cells of astrocytic and neuronal morphology. Importantly, whole-body bioluminescence persisted up to 240 days. We have validated a novel biosensor technology in an AAV system by using an NFκB response element and revealed its potential to monitor signalling pathway in a non-invasive manner in a model of LPS-induced inflammation. This technology complements existing germline-transgenic models and may be applicable to other rodent disease models. ispartof: SCIENTIFIC REPORTS vol:10 issue:1 ispartof: location:England status: published

Introduction: Choroideremia and RPGR-associated retinitis pigmentosa (RP) are two distinct inherited rod-cone degenerations, where good visual acuity (VA) is maintained until late disease stages, limiting its usefulness as a disease marker. Low luminance VA and low luminance deficit (standard VA minus low luminance VA) may be more sensitive visual function measures. Methods: Standard VA was obtained using Early Treatment Diabetic Retinopathy Study letter charts (Precision Vision, Bloomington, IL, USA). Low luminance VA was assessed using a 2.0-log unit neutral density filter, with the same chart setup, without formal dark adaptation. Mean central retinal sensitivity was assessed using MAIA microperimetry (Centervue SpA, Padova, Italy). Optical coherence tomography imaging was attained with Heidelberg Eye Explorer software (Heidelberg Engineering, Heidelberg, Germany). Results: Twenty-four male participants with confirmed pathogenic RPGR mutations, 44 male participants with confirmed pathogenic CHM mutations, and 62 age-matched controls underwent clinical assessment prior to clinical trial recruitment. Low luminance VA was significantly reduced in both disease groups compared to controls. The low luminance deficit correlated with microperimetry retinal sensitivity and ellipsoid zone width. Eleven participants with moderate VA had poor low luminance VA (subsequently a large low luminance deficit), no detectable microperimetry sensitivity, and severely constricted ellipsoid zone widths. Conclusions:Low luminance VA and subsequently low luminance deficit are useful markers of central macular visual function in both choroideremia and RPGR-associated RP, when standard VA is preserved. Translational Relevance: Low luminance visual acuity and low luminance deficit are useful vision measures in two distinct rod-cone degenerations and may be useful in other retinal degenerations.

Purpose: The measurement of standard visual acuity (VA) is the most well‐known part of any ophthalmic examination to indicate visual function. Despite this, it is insensitive in detecting early disease changes. Therefore, other visual function tests have been developed including low luminance VA (LLVA) and low luminance deficit (LLD). This scoping literature review aims to summarise the current published applications of LLVA and LLD assessments to evaluate their utility as clinical markers and research outcome measures in a variety of ophthalmic conditions. Recent findings: Sixty‐five peer‐reviewed publications were included. LLVA was pioneered for use in geographic atrophy, a subtype of age‐related macular degeneration, which remains the mainstay of its clinical application. However, other studies have reported additional useful applications in inherited retinal diseases including rare maculopathies and rod‐cone dystrophies. Although there are some variations in testing methodology, use of the standard Early Treatment Diabetic Retinopathy Study (ETDRS) chart with a 2.0 log unit neutral density filter is the most popular approach. The optimal testing luminance is still to be defined. Summary: Overall, LLVA is an earlier clinical marker of change in central retinal function than standard VA. It has been shown to be a risk factor for disease progression and a better indicator of a patient’s level of everyday visual function. It is inexpensive and simple to implement using readily available standard ophthalmic equipment.

Data were collected using multimodal monitoring technologies pairing sound recorders with time-lapse camera systems. In the spring of 2015, 2016, and 2017, sound recordings and imagery were collected at a wet meadow and forested slough in the Central Platte River Valley of Nebraska. Boreal chorus frog (Pseudacris maculata) calling activity was obtained from analysing sound recordings. Habitat metrics including vegetation phenology and wet meadow hydropattern were derived from image analysis. This dataset can be used to assess phenology, anuran vocalization activity, and environmental change, as well as to further understanding of wetland ecology. Data are co-submitted with manuscript Brinley Buckley, E. M., Gottesman, B. L., Caven, A. J., Harner, M. J., and Pijanowski, B. C., Assessing ecological and environmental influences on Boreal Chorus Frog (Pseudacris maculata) spring calling phenology using multimodal passive monitoring technologies. Ecological Indicators (In Press).

On 21 August 2017, a total solar eclipse crossed the continental United States, providing a unique natural experiment to observe how wildlife and plants respond to rapid and drastic changes in photic conditions using a multi-modal suite of tools. We installed passive time-lapse and infrared cameras, sound recorders, and data loggers in the Central Platte River Valley of Nebraska to study this phenomenon. The eclipse lasted about three hours, and complete obscuration of the sun (totality) lasted for about 2 min and 30 sec. Light values, measured with time-lapse camera systems, decreased 67% on average during totality relative to the daily mean light value. Ambient temperatures decreased by 6.7 °C on average (12% of the daily mean) approximately 11–16 min after totality; concurrently, humidity increased by an average of 12% of the daily mean. We found evidence for altered acoustic activity in response to the eclipse, including site and species-specific changes in the call activities of late season breeding birds and insects in the orders orthoptera and hemiptera. In addition, acoustic indices were differentially correlated with changes in photic and thermal conditions. However, we did not observe changes in flowering plants nor detect bat activity at known night roost and foraging areas. Historically, observations during rare occurrences, such as a total solar eclipse, were anecdotal or limited in scope, and thus, how they changed the light, sound, and meteorological conditions on the landscape were difficult to validate and measure. In comparison, anthropogenic disturbances, including impacts from light pollution and climate change, often take place slowly over long periods, and therefore, can be complex and challenging to assess. Documentation of this stochastic occurrence, with an immediate change in environmental conditions, highlights the utility of passive multimedia technologies to increase our capacity to monitor ecosystem dynamics and chronicle the variations of abiotic properties of a landscape and concomitant responses of organisms with varying sensory abilities.

The datasets in this article are associated with the research article ‘Assessing biological and environmental effects of a total solar eclipse with passive multimodal technologies’ (Brinley Buckley et al., 2018). We documented biotic and abiotic changes during a total solar eclipse on 21 August 2017, in south-central Nebraska, USA, with a multimodal suite of tools, including time-lapse camera systems, data loggers, and sound recording devices. Time-lapse images were used to approximate changes in light, data loggers were used to record temperature and humidity, and sound recordings were used to calculate acoustic indices characterizing variation in the soundscape, as well as to manually identify and estimate avian vocalization activity.

Drawing from positive organizational behavior, psychological capital has been shown to be a beneficial resource allowing leaders to remain positive and future-oriented. While having hope, optimism, confidence, and resilience are particularly effective in periods of great risk and uncertainty, extreme environments likely affect leaders’ psychological capital, as evidenced by changes to these comprising factors. Answering several recent calls for historical and narrative-based approaches to leadership in extreme events, we use content analysis and historiometrics in the case of Benjamin Montgomery, the first African American plantation owner in the post–Civil War U.S. South, who faced a sequence of extreme events after purchasing the plantation on which he was formerly a slave. We triangulate our examination through the letters Montgomery penned to his former owner Joseph Davis—the older brother of Confederacy President Jefferson Davis, records on the focal actors, and historical documents from the period. We then reconstruct and examine the relative contextual severity and its impact on Montgomery’s psychological capital across a 6-year period directly following the Civil War (1865-1870). We find that while unfamiliar extreme episodes erode leader psychological capital, those resources are restored when such periods are overcome and experience is gained. We also reconsider psychological capital as a profile multidimensional construct and show underlying pairs of dimensions, which we label as overt positivity (optimism and resilience) and realistic positivity (hope and confidence), trend similarly yet remain distinct from the other pair. The implications of these findings and future directions are then discussed.

The COVID-19 pandemic has altered the business world in historic proportions. Whereas the short-term effects have been felt by many, the long-term effects of the pandemic will likely create paradigm shifts of unknown impact. The novelty of this situation has had drastic and potentially lasting organizational effects. We use existing research to explore and presage the effects of these paradigm shifts across multiple domains including: job security, financial consequences, remote work, worker wellbeing, and career attitudes. By exploring the implications in each area of business, the hope is that researchers and practitioners can better prepare for a post-pandemic future.

In vivo bioluminescent imaging allows the detection of reporter gene expression in rodents in real time. Here we describe a novel technology whereby we can generate somatotransgenic rodents with the use of a viral vector carrying a luciferase transgene. We are able to achieve long term luciferase expression by a single injection of lentiviral or adeno-associated virus vectors to newborn mice. Further, we describe whole body bioluminescence imaging of conscious mice in a noninvasive manner, thus enforcing the 3R’s (replacement, reduction, and refinement) of biomedical animal research.

Purpose Mean retinal sensitivity is the main output measure used in microperimetry. It is, however, of limited use in patients with poor vision because averaging is weighted toward zero in those with significant scotomas creating an artificial floor effect. In contrast, volumetric measures avoid these issues and are displayed graphically as a hill of vision. Methods An open-source program was created to manipulate raw sensitivity threshold data files obtained from MAIA microperimetry. Thin plate spline interpolated heat maps and three-dimensional hill of vision plots with an associated volume were generated. Retrospective analyses of microperimetry volumes were undertaken in patients with a range of retinal diseases to assess the qualitative benefits of three-dimensional visualization and volumetric measures. Simulated pathology was applied to radial grid patterns to investigate the performance of volumetric sensitivity in nonuniform grids. Results Volumetric analyses from microperimetry in RPGR-related retinitis pigmentosa, choroideremia, Stargardt disease, and age-related macular degeneration were analyzed. In simulated nonuniform testing grids, volumetric sensitivity was able to detect differences in retinal sensitivity where mean sensitivity could not. Conclusions Volumetric measures do not suffer from averaging issues and demonstrate superior performance in nonuniform testing grids. Additionally, volume measures enable detection of localized retinal sensitivity changes that might otherwise be undetectable in a mean change. Translational relevance As microperimetry has become an outcome measure in several gene-therapy clinical trials, three-dimensional visualization and volumetric sensitivity enables a complementary analysis of baseline disease characteristics and subsequent response to treatment, both as a signal of safety and efficacy.

Time banditry recently has been introduced as a distinct construct in the counterproductive work behavior literature. Employees are engaged in time banditry when they pursue non–task-related activities during work time. We posit that they capitalize on the ambiguity in most work environments to manage impressions that their time banditry behavior really is productive and not counterproductive work behavior. In this investigation, two studies were conducted to explore variables that can be used to classify time bandits into four different categories. Discriminant function analysis was used to determine individual-level and job-level factors that classify time bandits. Results revealed that both situational and dispositional variables can be used to predict time bandit type. Suggestions for future research and implications for managing, reducing, and changing time banditry behaviors are discussed.

Bioluminescence imaging enables noninvasive quantification of luciferase reporter gene expression in transgenic tissues of living rodents. Luciferase transgene expression can be regulated by endogenous gene promoters after targeted knock-in of the reporter gene, usually within the first intron of the gene. Even using CRISPR/Cas9 mediated genome editing this can be a time consuming and costly process. The generation of germline transgenic (GLT) rodents by targeted genomic integration of a gene expression cassette in embryonic stem (ES) cells is commonplace but results in the wastage of large numbers of animals during colony generation, back-crossing and maintenance. Using a synthetic/truncated promoter-driven luciferase gene to study promoter activity in a given tissue or organ of a GLT also often results in unwanted background luciferase activity during whole-body bioluminescent imaging as every cell contains the reporter. We have developed somatotransgenic bioimaging; a method to generate tissue-restricted transcription factor activated luciferase reporter (TFAR) cassettes in rodents that substantially reduces the number of animals required for experimentation. Bespoke designed TFARs are delivered to newborn pups using viral vectors targeted to specific organs by tissue-tropic pseudotypes. Retention and proliferation of TFARs is facilitated by stem/progenitor cell transduction and immune tolerance to luciferase due to the naïve neonatal immune system. We have successfully applied both lentiviral and adeno-associated virus (AAV) vectors in longitudinal rodent studies, targeting TFARs to the liver and brain during normal development and in well-established disease models. Development of somatotransgenic animals has broad applicability to non-invasively determine mechanistic insights into homeostatic and disease states and assess toxicology and efficacy testing. Somatotransgenic bioimaging technology is superior to current whole-body, light-emitting transgenic models as it reduces the numbers of animals used by generating only the required number of animals. It is also a refinement over current technologies given the ability to use conscious, unrestrained animals.

Over 80% of the Mid-Continent Sandhill Crane (Antigone canadensis) Population (MCP), estimated at over 660,000 individuals, stops in the Central Platte River Valley (CPRV) during spring migration from mid-February through mid-April. Research suggests that the MCP may be shifting its distribution spatially and temporally within the CPRV. From 2002 to 2017, we conducted weekly aerial surveys of Sandhill Cranes staging in the CPRV to examine temporal and spatial trends in their abundance and distribution. Then, we used winter temperature and drought severity measures from key wintering and early migratory stopover locations to assess the impacts of weather patterns on annual migration chronology in the CPRV. We also evaluated channel width and land cover characteristics using aerial imagery from 1938, 1998, and 2016 to assess the relationship between habitat change and the spatial distribution of the MCP in the CPRV. We used generalized linear models, cumulative link models, and Akaike's information criterion corrected for small sample sizes (AICc) to compare temporal and spatial models. Temperatures and drought conditions at wintering and migration locations that are heavily used by Greater Sandhill Cranes (A. c. tabida) best predicted migration chronology of the MCP to the CPRV. The spatial distribution of roosting Sandhill Cranes from 2015 to 2017 was best predicted by the proportion of width reduction in the main channel since 1938 (rather than its width in 2016) and the proportion of land cover as prairie-meadow habitat within 800 m of the Platte River. Our data suggest that Sandhill Cranes advanced their migration by an average of just over 1 day per year from 2002 to 2017, and that they continued to shift eastward, concentrating at eastern reaches of the CPRV. Climate change, land use change, and habitat loss have all likely contributed to Sandhill Cranes coming earlier and staying longer in fewer reaches of the CPRV, increasing their site use intensity. These historically unprecedented densities may present a disease risk to Sandhill Cranes and other waterbirds, including Whooping Cranes (Grus americana). Our models suggest that conservation actions may be maintaining Sandhill Crane densities in areas that would otherwise be declining in use. We suggest that management actions intended to mitigate trends in the distribution of Sandhill Cranes, including wet meadow restoration, may similarly benefit prairie- and braided river–endemic species of concern.

We have previously designed a library of lentiviral vectors to generate somatic-transgenic rodents to monitor signalling pathways in diseased organs using whole-body bioluminescence imaging, in conscious, freely moving rodents. We have now expanded this technology to adeno-associated viral vectors. We first explored bio-distribution by assessing GFP expression after neonatal intravenous delivery of AAV8. We observed widespread gene expression in, central and peripheral nervous system, liver, kidney and skeletal muscle. Next, we selected a constitutive SFFV promoter and NFκB binding sequence for bioluminescence and biosensor evaluation.An intravenous injection of AAV8 containing firefly luciferase and eGFP under transcriptional control of either element resulted in strong and persistent widespread luciferase expression. A single dose of LPS-induced a 10-fold increase in luciferase expression in AAV8-NFκB mice and immunohistochemistry revealed GFP expression in cells of astrocytic and neuronal morphology. Importantly, whole-body bioluminescence persisted up to 240 days.To further restrict biosensor activity to the CNS, we performed intracerebroventricular injection of each vector. We observed greater restriction of bioluminescence to the head and spine with both vectors. Immunohistochemistry revealed strongest expression in cells of neuronal morphology. LPS administration stimulated a 4-fold increase over baseline bioluminescence.We have validated a novel biosensor technology in an AAV system by using an NFκB response element and revealed its potential to monitor signalling pathway in a non-invasive manner using a model of LPS-induced inflammation. This technology employs the 3R’s of biomedical animal research, complements existing germline-transgenic models and may be applicable to other rodent disease models with the use of different response elements.

Preterm birth is a serious global health problem and the leading cause of infant death before 5 years of age. At least 40% of cases are associated with infection. The most common way for pathogens to access the uterine cavity is by ascending from the vagina. Bioluminescent pathogens have revolutionized the understanding of infectious diseases. We hypothesized that bioluminescent Escherichia coli can be used to track and monitor ascending vaginal infections. Two bioluminescent strains were studied: E. coli K12 MG1655-lux, a nonpathogenic laboratory strain, and E. coli K1 A192PP-lux2, a pathogenic strain capable of causing neonatal meningitis and sepsis in neonatal rats. On embryonic day 16, mice received intravaginal E. coli K12, E. coli K1, or phosphate-buffered saline followed by whole-body bioluminescent imaging. In both cases, intravaginal delivery of E. coli K12 or E. coli K1 led to bacterial ascension into the uterine cavity, but only E. coli K1 induced preterm parturition. Intravaginal administration of E. coli K1 significantly reduced the proportion of pups born alive compared with E. coli K12 and phosphate-buffered saline controls. However, in both groups of viable pups born after bacterial inoculation, there was evidence of comparable brain inflammation by postnatal day 6. This study ascribes specific mechanisms by which exposure to intrauterine bacteria leads to premature delivery and neurologic inflammation in neonates.

In this article, we proffer a theoretical integration of current emotions research and impression management (IM) tactics as applied to the workplace. Both IM and emotions frequently occur in organizational settings, but research has yet to consider how their simultaneous implementation may impact the ability of an individual to influence the perceptions others form of them. By integrating the emotions as social information model and a cybernetic model of IM, we attempt to explain the linkage between actor implementation of IM behaviour, paired affective displays, and downstream processing and resultant behaviour by a target. Situational and personal moderators that may impact this process are also discussed. Successful application of emotions in IM can have wide-ranging implications for outcomes of interest in human resource management, and these are discussed within several IM frameworks. Practitioner points We integrate theory and research on emotions and IM to help develop an understanding of their impact on others in the workplace. A model is provided to show how this integration may influence human resource management. Examples of this integration are shown via extant IM frameworks.

Purpose – The purpose of this paper is to examine how the effectiveness of delegation as a management practice is impacted by various factors such as manager cognition, perceived subordinate competence, and cultural differences. This research may help global business leaders to better understand how cultural differences may impact managerial functions and how to manage culturally diverse employees. Design/methodology/approach – This paper is based upon a conceptual discussion of delegation as it has been studied in the past and a reflection on the ways in which past research can usefully inform current trends in the use of delegation as a management practice. Findings – A model is proposed that suggests that the effectiveness of delegation in a local context is a function of the global leader’s cognitions and perceptions of their subordinates. Further, it suggests that this relationship is moderated by the local cultural context in that some cultures may be opposed to being delegated authority. Research limitations/implications – This paper presents a conceptual framework and therefore empirical applicability of this model must be proven. Originality/value – Delegation is an under-researched management practice. This paper contributes to the delegation literature by exploring its value to management in a global context.

The construct validity of employment interviews is the greatest challenge faced by employment interview researchers. In this paper, we discuss the theoretical and methodological issues which have an influence upon the construct validity of employment interviews. We pay special attention to issues that emerge at the conceptual development and design stage of interviews. So far, the structuring of employment interviews has been the primary method of improving construct validity. We argue that construct validity can be further improved by bringing theoretical rigor in the design of interviews. For this purpose, we propose steps to reframe the interview dimensions in theoretical frameworks of job performance, to explicate the nomological network of interview constructs, to clarify the validation strategy, and to improve the questions and assessment keys. In the end, we provide an example to illustrate the application of these steps.

Supportive supervision is doubtlessly beneficial in many instances in organizations. Paustian- Underdahl, Shanock, Rogelberg, Scott, Justice, and Altman () have examined the predictors of supportive supervision. We might suggest that they have underidentified those factors that impact the potential influence of supportive supervision and suggest a more comprehensive approach to this important variable. [ABSTRACT FROM AUTHOR]