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Your search keyword '"Ishikura, Minoru"' showing total 17 results
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17 results on '"Ishikura, Minoru"'

1. Palladium-catalyzed carbonylative cross-coupling reaction with triethyl-(1-methylindol-2-yl)borate: a simple route to 1-methylindol-2-yl ketones

Author

Ishikura, Minoru and Terashima, Masanao

Subjects
Borates -- Research, Palladium catalysts -- Analysis, Stereochemistry -- Analysis, Biological sciences, Chemistry
Abstract

Indolylborates, prepared in situ from 2-bithio-1-methylindol and triethyl borane, form indol-2-yl-ketones by palladium-catalyzed carbonylative cross-coupling reactions. These reactions are fast under carbon monoxide in THF with vinyltriflates at 60 degrees C. All reactions are done in a single vessel. Stereochemistries of the compounds are assigned by NOE studies.

Published
1994

2. Indium(III)-catalyzed tandem reaction with alkynylbenzaldehydes and alkynylanilines to heteroaromatic compounds

Author

Yanada Reiko, Hashimoto, Kana, Tokizane, Rie, Miwa, Yoshihisa, Minami, Hideki, Yanada, Kazuo, Ishikura, Minoru, and Takemoto, Yoshiji

Subjects
Aldehydes -- Chemical properties, Aniline -- Chemical properties, Catalysis -- Analysis, Ring formation (Chemistry) -- Analysis, Indium -- Chemical properties, Biological sciences, Chemistry
Abstract

The development of a new atom-economical In[(OTf).sub.3]-catalyzed synthesis of ring-condensed heteroaromatic compounds via a domino intramolecular nucleophilic attack/intermolecular cycloaddition/dehydration reaction is reported. The synthesis used readily available ortho-alkynylanilines and ortho-alkynylbenzaldehydes as starting materials.

Published
2008

3. A novel synthesis of 3,4,5,6-tetrahydro-7-hydroxy-1H-azepino[5,4,3-cd] indole derivatives from serotonin1

Author

Yamada, Koji, Teranishi, Sakiko, Miyashita, Ayako, Ishikura, Minoru, and Somei, Masanori

Abstract

Utilizing novel Nb-substituted serotonins, 5-and/or 6-substituted 3,4,5,6-tetrahydro-7-hydroxy-1H-azepino[5,4,3-cd]indole derivatives are produced simply by treating serotonins with aldehydes under basic conditions. Synthesis of 2,2a,3,4,5,6-hexahydro-7-hydroxy-1H-azepino[5,4,3-cd]indole-2-one derivatives is also reported. © 2011 The Japan Institute of Heterocyclic Chemistry.

Published
2011

4. Synthesis and antimalarial activity of calothrixins A and B, and their N-alkyl derivatives

Author

Matsumoto, Kohji, Choshi, Tominari, Hourai, Mai, Zamami, Yoshito, Sasaki, Kenji, Abe, Takumi, Ishikura, Minoru, Hatae, Noriyuki, Iwamura, Tatsunori, Tohyama, Shigeo, Nobuhiro, Junko, and Hibino, Satoshi

Subjects
Antimalarials, Structure-Activity Relationship, Alkylation, Molecular Structure, parasitic diseases, Plasmodium falciparum, Indole Alkaloids
Abstract

We synthesized calothrixin B using our developed biomimetic method and derived N-alkyl-calothrixins A and B. The in vitro antimalarial activity of the calothrixin derivatives, including calothrixins A and B, against the Plasmodium falciparum FCR-3 strain was evaluated. All test compounds exhibited antimalarial activity over a concentration range of 6.4×10(-6)-1.2×10(-7) M.

Published
2013

17. Synthesis of carbocyclic nucleosides bearing a cyclopropane ring

Author

Yamatoya, Yoshitsugu, Ishikura, Minoru, and Katagiri, Nobuya

Abstract

A carbocyclic cyclopropane fused nucleoside, 9-(<it>c</it>-4-hydroxy- methylbicyclo[3.1.0]hex-<it>r</it>-2-yl)-9H-adenine, has been efficiently synthesized from 2-azabicyclo-[2.2.1]hex-5-en-3-one(ABH) in 6 steps, namely cyclopropanation, reductive amide cleavage (RAC) reaction and adenine ring construction.

Published
1999
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