Synthesis and antimalarial activity of calothrixins A and B, and their N-alkyl derivatives

Authors :: Matsumoto, Kohji
Choshi, Tominari
Hourai, Mai
Zamami, Yoshito
Sasaki, Kenji
Abe, Takumi
Ishikura, Minoru
Hatae, Noriyuki
Iwamura, Tatsunori
Tohyama, Shigeo
Nobuhiro, Junko
Hibino, Satoshi
Source :: 福山大学薬学部研究年報 = Annual report of the Faculty of Pharmacy & Pharmaceutical Sciences, Fukuyama University. 31:22-22
Publication Year :: 2013
Publisher :: 福山大学薬学部, 2013.
Abstract: We synthesized calothrixin B using our developed biomimetic method and derived N-alkyl-calothrixins A and B. The in vitro antimalarial activity of the calothrixin derivatives, including calothrixins A and B, against the Plasmodium falciparum FCR-3 strain was evaluated. All test compounds exhibited antimalarial activity over a concentration range of 6.4×10(-6)-1.2×10(-7) M.

Subjects :: Antimalarials
Structure-Activity Relationship
Alkylation
Molecular Structure
parasitic diseases
Plasmodium falciparum
Indole Alkaloids

Language :: English
ISSN :: 0288724X
Volume :: 31
Database :: OpenAIRE
Journal :: 福山大学薬学部研究年報 = Annual report of the Faculty of Pharmacy & Pharmaceutical Sciences, Fukuyama University
Accession number :: edsair.jairo.........cfd53d5affcf496007be1172b81ccd7f

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