Search

Summary A hallmark of Parkinson's disease (PD) is the preferential loss of substantia nigra dopamine neurons. Here, we identify a new par kin i nteracting s ubstrate, PARIS (ZNF746), whose levels are regulated by the ubiquitin proteasome system via binding to and ubiquitination by the E3 ubiquitin ligase, parkin. PARIS is a KRAB and zinc finger protein that accumulates in models of parkin inactivation and in human PD brain. PARIS represses the expression of the transcriptional coactivator, PGC-1α and the PGC-1α target gene, NRF-1 by binding to insulin response sequences in the PGC-1α promoter. Conditional knockout of parkin in adult animals leads to progressive loss of dopamine (DA) neurons in a PARIS-dependent manner. Moreover, overexpression of PARIS leads to the selective loss of DA neurons in the substantia nigra, and this is reversed by either parkin or PGC-1α coexpression. The identification of PARIS provides a molecular mechanism for neurodegeneration due to parkin inactivation. PaperClip

In this study, we have developed high performance TFT (thin film transistor) and a 7.4-inch high resolution LCD (liquid crystal display) panel of full color WSXGA (1600 × RGB × 1024, 257 ppi, 43% aperture ratio) format using ‘sequential lateral solidification (SLS)’ laser crystallization process [Y.J. Kim et al., Grain boundary effect on the characteristics of the high-performance poly-Si TFTs crystallized by SLS Technique, AM-LCD (2005) 249–251]. The gate and data driver circuits were integrated on panel and the integrated drivers comprise a sequential analog sampling data driver and a dual logic gate scanner for redundancy. In addition, we have improved key process for fine image quality. Metal lines used Cu/MoX (5000 A/300 A) for uniform data transfer and array on BM (black matrix) structure for lager aperture ratio was adopted.

We present the latest results of the use of soluble materials such as organic semiconductors (OSCs) or gate-dielectrics for simplified processing of organic thin-film transistors (OTFTs). In this paper, we described our fabrication of a solution-processed OTFT with 6,13-bis(triisopropylsilylethynyl) pentacene (TIPS-pentacene) as the OSC and siloxane-based spin-on glass (SOG) as the inorganic gate-dielectric. Also, synthesized TIPS-pentacene and SOG were examined for use as the OSC and gate-dielectric in an OTFT. From electrical measurements, we obtained device performance characteristics such as charge carrier mobility, threshold voltage, current ON/OFF ratio, and subthreshold swing, which were 6.48 times 10-3 cm2/V ldr s, -13 V, ~100, and 1.83 V/dec, respectively.

By the integrated drive circuitry with laser crystallization process, the gate and data driver circuits required for full color WVGA(800 × RGB × 480) LCD are integrated on panel. The integrated driver comprises a sequential analog sampling data driver and a dual logic gate scanner for redundancy. The characteristics and uniformities of the LTPS (low temperature polycrystalline silicon) devices have been remarkably enhanced by applying stacked SiO2 and SiNx buffer layers and surface treatment.