1. CD68-Negative Histiocytoses with Cardiac Involvement, Associated with COVID-19.
- Author
-
Mitrofanova L, Korneva L, Makarov I, Bortsova M, Sitnikova M, Ryzhkova D, Kudlay D, and Starshinova A
- Subjects
- Humans, Male, Female, Middle Aged, Aged, Erdheim-Chester Disease metabolism, Erdheim-Chester Disease pathology, Erdheim-Chester Disease diagnosis, Spike Glycoprotein, Coronavirus metabolism, Infant, CD68 Molecule, Receptors, Cell Surface, COVID-19 metabolism, COVID-19 pathology, COVID-19 complications, COVID-19 virology, Antigens, Differentiation, Myelomonocytic metabolism, Antigens, CD metabolism, SARS-CoV-2 metabolism, Histiocytosis pathology, Histiocytosis metabolism
- Abstract
Histiocytoses are rare diseases characterised by infiltration of affected organs by myeloid cells with a monocyte or dendritic cell phenotype. Symptoms can range from self-resolving localised forms to multisystemic lesions requiring specific treatment. To demonstrate extremely rare cases of CD68-negative cardiac histiocytosis with expression of SARS-CoV-2 antigen in infiltrate cells. We demonstrated a case of Erdheim-Chester disease in a 67-year-old man with pericardial involvement and positive dynamics with vemurafenib treatment, an autopsy case of xanthogranulomatous myopericarditis in a 63-year-old man, surgical material of xanthogranulomatous constrictive pericarditis in a 57-year-old man, and an autopsy case of xanthogranulomatosis in a 1-month-old girl. In all cases, xanthogranuloma cells expressed CD163, many of them spike protein SARS-CoV-2, while CD68 expression was detected only in single cells. In this article, we demonstrated four cases of extremely rare CD68-negative cardiac xanthogranulomatosis in three adults and one child with expression of the spike protein SARS-CoV-2 in M2 macrophages. This potential indirect association between COVID-19 and the development of histiocytosis in these patients warrants further investigation. To substantiate this hypothesis, more extensive research is needed.
- Published
- 2024
- Full Text
- View/download PDF