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Indeterminate cell histiocytosis: a case report.
- Source :
-
The Kaohsiung journal of medical sciences [Kaohsiung J Med Sci] 2004 Jan; Vol. 20 (1), pp. 24-30. - Publication Year :
- 2004
-
Abstract
- Indeterminate cell histiocytosis is a rare neoplasm composed of cells with mixed characteristics of Langerhans cells and non-Langerhans cells. An otherwise healthy, 36-year-old woman presented with asymptomatic generalized papules and nodules that had appeared on all four extremities, the trunk, and cheeks in the previous 6 months. The lesions were firm, painless, non-pruritic, and slightly flesh-yellow or reddish-brown in color. Histopathologic, immunohistochemical examination and electron microscopic studies showed characteristic findings of indeterminate cell histiocytosis: diffuse proliferative histiocytes infiltrating the dermis without epidermotropism or atypia; neoplastic cells expressing markers characteristic of both Langerhans cells (CD1a, S-100) and focal monocytes/macrophages (Factor XIIIa, CD68); and no Birbeck granules within the cytoplasm of the neoplastic cells. Flow cytometry revealed more CD34+ cells in the peripheral blood of the patient than in peripheral blood from a control. Interestingly, the patient responded favorably to psoralen ultraviolet A-range treatment. Herein, we present this case and review the literature.
Details
- Language :
- English
- ISSN :
- 1607-551X
- Volume :
- 20
- Issue :
- 1
- Database :
- MEDLINE
- Journal :
- The Kaohsiung journal of medical sciences
- Publication Type :
- Academic Journal
- Accession number :
- 15481563
- Full Text :
- https://doi.org/10.1016/S1607-551X(09)70080-4