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1. Low-density lipoprotein particle profiles compared with standard lipids measurements in the association with asymptomatic intracranial artery stenosis

Author

Vu, Thien, Yano, Yuichiro, Pham, Huy Kien Tai, Mondal, Rajib, Ohashi, Mizuki, Kitaoka, Kaori, Moniruzzaman, Mohammad, Torii, Sayuki, Shiino, Akihiko, Tsuji, Atsushi, Hisamatsu, Takashi, Okamura, Tomonori, Kondo, Keiko, Kadota, Aya, Watanabe, Yoshiyuki, Nozaki, Kazuhiko, Ueshima, Hirotsugu, and Miura, Katsuyuki

Published
2024
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5. Coronary Artery Calcium Progression Among the US and Japanese Men

Author

Hisamatsu, Takashi, Liu, Kiang, Chan, Cheeling, Krefman, Amy E, Fujiyoshi, Akira, Budoff, Matthew J, Miura, Katsuyuki, Lloyd-Jones, Donald M, and Ueshima, Hirotsugu

Subjects
Biomedical and Clinical Sciences, Cardiovascular Medicine and Haematology, Clinical Sciences, Behavioral and Social Science, Clinical Research, Heart Disease - Coronary Heart Disease, Heart Disease, Atherosclerosis, Prevention, Cardiovascular, Black or African American, Aged, Asian, Computed Tomography Angiography, Coronary Angiography, Coronary Artery Disease, Disease Progression, Health Status Disparities, Hispanic or Latino, Humans, Incidence, Japan, Longitudinal Studies, Male, Middle Aged, Prognosis, Prospective Studies, Racial Groups, Risk Assessment, Risk Factors, Severity of Illness Index, United States, Vascular Calcification, White People, coronary disease, ethnic groups, humans, risk factors, Cardiovascular System & Hematology, Cardiovascular medicine and haematology, Clinical sciences
Abstract

Background The risk of coronary heart disease remains low in Japan, although distributions of several coronary risk factors have become comparable with those in the United States. We prospectively compared coronary atherosclerosis burden, measured with coronary artery calcium (CAC) progression, between men in the 2 countries. Methods In 2 population-based samples of 1712 US White, Black, Hispanic, Chinese men (baseline, 2000-2002) and 697 Japanese men in Japan (2006-2008) aged 45-74 years without clinical cardiovascular disease, we quantified CAC progression by serial computed tomography with medians of 3.4 and 5.2 years between scans, respectively. Results Among White, Black, Hispanic, Chinese, and Japanese men free of baseline CAC, CAC incidence was observed in 35.2%, 26.9%, 29.2%, 18.9%, and 29.2%, respectively. After adjustment for times between scans, demographics, behaviors, coronary risk factors, and their changes between scans, White men had significantly higher CAC incidence than Japanese men (relative risk, 1.68; 95% CI, 1.13-2.50). Among those with detectable baseline CAC, after similar adjustments, all the US race/ethnic groups had significantly greater annual changes in CAC score (mean [95% CI]: 39.4 [35.2-43.6] for White, 26.9 [21.4-32.4] for Black, 30.6 [24.7-36.5] for Hispanic, and 30.2 [22.6-37.8] for Chinese men) than Japanese men (15.9 [10.1-21.8]). Conclusions We found a higher CAC incidence among US White men and greater increases in existing CAC among all the US race/ethnic groups than among Japanese men in Japan. These differences persisted despite adjustment for differences in coronary risk factors.

Published
2019

7. Association of Anthropometric and CT-Based Obesity Indices with Subclinical Atherosclerosis

Author

Higo, Yosuke, primary, Hisamatsu, Takashi, additional, Nakagawa, Yoshihisa, additional, Sawayama, Yuichi, additional, Yano, Yuichiro, additional, Kadota, Aya, additional, Fujiyoshi, Akira, additional, Kadowaki, Sayaka, additional, Torii, Sayuki, additional, Kondo, Keiko, additional, Watanabe, Yoshiyuki, additional, Ueshima, Hirotsugu, additional, and Miura, Katsuyuki, additional

Published
2024
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9. Relationship between Serum Irisin Levels and MRI-Measured Cerebral Small Vessel Disease in Japanese Men

Author

Moniruzzaman, Mohammad, primary, Kadota, Aya, additional, Hisamatsu, Takashi, additional, Segawa, Hiroyoshi, additional, Kondo, Keiko, additional, Torii, Sayuki, additional, Miyagawa, Naoko, additional, Fujiyoshi, Akira, additional, Yano, Yuichiro, additional, Watanabe, Yoshiyuki, additional, Shiino, Akihiko, additional, Nozaki, Kazuhiko, additional, Ueshima, Hirotsugu, additional, and Miura, Katsuyuki, additional

Published
2023
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12. Association of blood levels of marine omega-3 fatty acids with coronary calcification and calcium density in Japanese men

Author

Sekikawa, Akira, Mahajan, Hemant, Kadowaki, Sayaka, Hisamatsu, Takashi, Miyagawa, Naoko, Fujiyoshi, Akira, and Kadota, Aya

Subjects
Calcification (Physiology) -- Analysis, Atherosclerosis -- Development and progression -- Risk factors -- Analysis, Omega 3 fatty acids -- Analysis, Unsaturated fatty acids -- Analysis, Epidemiology -- Analysis, Medical schools -- Analysis, CAT scans, Clinical trials, Fatty acids, Tomography, Food/cooking/nutrition, Health
Abstract

Background/objectives: Clinical trials of eicosapentaenoic acid (EPA) among high-risk groups in Japan in which consumption of mairne-omega-3 fatty acids (OM3) is much higher than other countries showed slower progression of coronary atherosclerosis. We aimed to determine the cross-sectional associations of coronary artery calcification (CAC) and calcium density with OM3, EPA, and docosahexaenoic acid (DHA), two principal OM3, in the general population in Japan. Subjects/methods: The Shiga Epidemiological Study of Subclinical Atherosclerosis examined a population-based sample of 1074 men aged 40-79 in 2006-08 for computed tomography-measured CAC score (CCS), a well-established biomarker of coronary atherosclerosis, CAC density score (CDS), a potential marker of plaque stabilization, serum levels of OM3, and risk factors. Results: Prevalence of CCS > 0, [greater than or equal to] 100, and [greater than or equal to] 300 was 65.8%, 25.9%, and 12.9%, respectively; the mean (SD) OM3, EPA, and DHA were 10.1% (3.2), 3.2% (1.7), and 5.9% (1.6), respectively. Odds ratios (95% CI, p-value) of CCS 0, 100, and 300 in ordinal logistic regression associated with 1 SD increase of OM3, EPA, and DHA were 0.91 (0.81-1.03, p = 0.12), 0.99 (0.88-1.11, p = 0.87) and 0.84 (0.74-0.94, p = < 0.01), respectively. The inverse association of DHA with CCS remained significant in multivariate-adjusted model: odds ratio of 0.87 (0.77-0.99, p = 0.03). Blood levels of OM3, EPA, or DHA did not have any significant associations with CDS. Conclusions: DHA but not EPA had a significant inverse association with coronary atherosclerosis in the general population with high levels of OM3. Future trials are warranted comparing the effect of high-dose DHA and EPA on atherosclerosis and cardiovascular outcomes., Author(s): Akira Sekikawa [sup.1], Hemant Mahajan [sup.1], Sayaka Kadowaki [sup.2], Takashi Hisamatsu [sup.3], Naoko Miyagawa [sup.2], Akira Fujiyoshi [sup.2], Aya Kadota [sup.4], Hiroshi Maegawa [sup.5], Kiyoshi Murata [sup.6], Katsuyuki Miura [...]

Published
2019
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14. Lifetime cigarette smoking is associated with abdominal obesity in a community-based sample of Japanese men: The Shiga Epidemiological Study of Subclinical Atherosclerosis (SESSA)

Author

Fujiyoshi, Akira, Miura, Katsuyuki, Kadowaki, Sayaka, Azuma, Koichiro, Tanaka, Sachiko, Hisamatsu, Takashi, Arima, Hisatomi, Kadota, Aya, Miyagawa, Naoko, Takashima, Naoyuki, Ohkubo, Takayoshi, Saitoh, Yoshino, Torii, Sayuki, Miyazawa, Itsuko, Maegawa, Hiroshi, Murata, Kiyoshi, and Ueshima, Hirotsugu

Published
2016
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15. Non-missense variants ofKCNH2show better outcomes in type 2 long QT syndrome

Author

Aizawa, Takanori, primary, Wada, Yuko, additional, Hasegawa, Kanae, additional, Huang, Hai, additional, Imamura, Tomohiko, additional, Gao, Jingshan, additional, Kashiwa, Asami, additional, Kohjitani, Hirohiko, additional, Fukuyama, Megumi, additional, Kato, Koichi, additional, Kato, Eri Toda, additional, Hisamatsu, Takashi, additional, Ohno, Seiko, additional, Makiyama, Takeru, additional, Kimura, Takeshi, additional, and Horie, Minoru, additional

Published
2023
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16. Abstract P671: Association Between Renal Function and Silent Cerebrovascular Disease in Japanese Men

Author

Miyagawa, Naoko, primary, Takashima, Naoyuki, additional, Kadota, Aya, additional, Fujiyoshi, Akira, additional, Torii, Sayuki, additional, Segawa, Hiroyoshi, additional, Miyazawa, Itsuko, additional, Kume, Shinji, additional, Kondo, Keiko, additional, Hisamatsu, Takashi, additional, Yano, Yuichiro, additional, Shiino, Akihiko, additional, Nozaki, Kazuhiko, additional, Ueshima, Hirotsugu, additional, and Miura, Katsuyuki, additional

Published
2023
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17. Association and dose-response relationship between exposure to alcohol advertising media and current drinking: a nationwide cross-sectional study of Japanese adolescents

Author

Yoshida, Keita, primary, Kanda, Hideyuki, additional, Hisamatsu, Takashi, additional, Kuwabara, Yuki, additional, Kinjo, Aya, additional, Yoshimoto, Hisashi, additional, Ito, Teruna, additional, Kasuga, Hideaki, additional, Minobe, Ruriko, additional, Maesato, Hitoshi, additional, Jike, Maki, additional, Matsumoto, Yuuki, additional, Otsuka, Yuichiro, additional, Itani, Osamu, additional, Kaneita, Yoshitaka, additional, Higuchi, Susumu, additional, and Osaki, Yoneatsu, additional

Published
2023
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19. Relationship between Kidney Function and Subclinical Atherosclerosis Progression Evaluated by Coronary Artery Calcification

Author

Ganbaatar, Namuun, primary, Kadota, Aya, additional, Hisamatsu, Takashi, additional, Araki, Shin-Ichi, additional, Kume, Shinji, additional, Fujiyoshi, Akira, additional, Kadowaki, Sayaka, additional, Torii, Sayuki, additional, Kondo, Keiko, additional, Segawa, Hiroyoshi, additional, Salman, Ebtehal, additional, Miyazawa, Itsuko, additional, Yamamoto, Takashi, additional, Nakagawa, Yoshihisa, additional, Maegawa, Hiroshi, additional, Miura, Katsuyuki, additional, and Ueshima, Hirotsugu, additional

Published
2022
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20. Non-missense variants of KCNH2 show better outcomes in type 2 long QT syndrome.

Author

Aizawa, Takanori, Wada, Yuko, Hasegawa, Kanae, Huang, Hai, Imamura, Tomohiko, Gao, Jingshan, Kashiwa, Asami, Kohjitani, Hirohiko, Fukuyama, Megumi, Kato, Koichi, Kato, Eri Toda, Hisamatsu, Takashi, Ohno, Seiko, Makiyama, Takeru, Kimura, Takeshi, and Horie, Minoru

Abstract

Aims More than one-third of type 2 long QT syndrome (LQT2) patients carry KCNH2 non-missense variants that can result in haploinsufficiency (HI), leading to mechanistic loss-of-function. However, their clinical phenotypes have not been fully investigated. The remaining two-thirds of patients harbour missense variants, and past studies uncovered that most of these variants cause trafficking deficiency, resulting in different functional changes: either HI or dominant-negative (DN) effects. In this study, we examined the impact of altered molecular mechanisms on clinical outcomes in LQT2 patients. Methods and results We included 429 LQT2 patients (234 probands) carrying a rare KCNH2 variant from our patient cohort undergoing genetic testing. Non-missense variants showed shorter corrected QT (QTc) and less arrhythmic events (AEs) than missense variants. We found that 40% of missense variants in this study were previously reported as HI or DN. Non-missense and HI-groups had similar phenotypes, while both exhibited shorter QTc and less AEs than the DN-group. Based on previous work, we predicted the functional change of the unreported variants—whether they cause HI or DN via altered functional domains—and stratified them as predicted HI (pHI)- or pDN-group. The pHI-group including non-missense variants exhibited milder phenotypes compared to the pDN-group. Multivariable Cox model showed that the functional change was an independent risk of AEs (P = 0.005). Conclusion Stratification based on molecular biological studies enables us to better predict clinical outcomes in the patients with LQT2. [ABSTRACT FROM AUTHOR]

Published
2023
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22. Comparison of HOMA-IR, HOMA-β% and disposition index between US white men and Japanese men in Japan: the ERA JUMP study

Author

Ahuja, Vasudha, Kadowaki, Takashi, Evans, Rhobert W., Kadota, Aya, Okamura, Tomonori, El Khoudary, Samar R., Fujiyoshi, Akira, Barinas-Mitchell, Emma J. M., Hisamatsu, Takashi, Vishnu, Abhishek, Miura, Katsuyuki, Maegawa, Hiroshi, El-Saed, Aiman, Kashiwagi, Atsunori, Kuller, Lewis H., Ueshima, Hirotsugu, Sekikawa, Akira, and for the ERA JUMP Study Group

Published
2015
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23. Association of Alcohol Consumption With Fat Deposition in a Community-Based Sample of Japanese Men: The Shiga Epidemiological Study of Subclinical Atherosclerosis (SESSA)

Author

Sumi, Masaki, Hisamatsu, Takashi, Fujiyoshi , Akira, Kadota, Aya, Miyagawa, Naoko, Kondo, Keiko, Kadowaki, Sayaka, Suzuki , Sentaro, Torii, Sayuki, Zaid Maryam, Sato, Atsushi, Arima, Hisatomi, Terada, Tomohiro, Miura, Katsuyuki, Ueshima , Hirotsugu, Horie Minoru, Nakano Yasutaka, Yamamoto Takashi, Hayashi Hideki, Ogawa Emiko, Maegawa Hiroshi, Miyazawa Itsuko, Murata Kiyoshi, Mitsunami Kenichi, Nozaki Kazuhiko, Tooyama Ikuo, Shiino Akihiko, Tsuru Teruhiko, Ogita Hisakazu, Shimizu Akio, Miyamatsu Naomi, Kita Toru, Kimura Takeshi, Nishio Yoshihiko, Nakamura Yasuyuki, Okamura Tomonori, Sekikawa Akira, Barinas-Mitchell Emma J. M., Edmundowicz Daniel, Ohkubo Takayoshi, Hozawa Atsushi, Murakami Yoshitaka, Okuda Nagako, Arima Hisatomi, Kita Yoshikuni, Hisamatsu Takashi, Higashiyama Aya, Nagasawa Shinya, Azuma Koichiro, Yanagita Masahiko, Abbott Robert D., Kadota Aya, Ohno Seiko, Fujiyoshi Akira, Takashima Naoyuki, Kadowaki Takashi, Kadowaki Sayaka, Miyagawa Naoko, Kondo Keiko, Torii Sayuki, Saito Yoshino, Suzuki Sentaro, Ito Takahiro, Satoh Atsushi, and Yamazoe Masahiro

Subjects
Adult, Male, medicine.medical_specialty, Alcohol Drinking, Epidemiology, alcohol consumption, Population, Adipose tissue, 030209 endocrinology & metabolism, Intra-Abdominal Fat, 03 medical and health sciences, 0302 clinical medicine, Japan, Internal medicine, medicine, Humans, 030212 general & internal medicine, visceral adipose tissue, Adverse effect, education, Nutrition, Aged, lcsh:R5-920, education.field_of_study, Anthropometry, business.industry, anthropometric obesity indice, Confounding, nutritional and metabolic diseases, General Medicine, Middle Aged, medicine.disease, fat deposition, Obesity, Subcutaneous Fat, Abdominal, Epidemiologic Studies, Cross-Sectional Studies, Population Surveillance, Original Article, lcsh:Medicine (General), Tomography, X-Ray Computed, business, Body mass index
Abstract

Background: Excessive alcohol intake has been shown to be associated with cardiovascular disease via metabolic pathways. However, the relationship between alcohol intake and obesity has not been fully elucidated. We aimed to examine the association of alcohol consumption with fat deposition and anthropometric measures. Methods: From 2006–2008, we conducted a cross-sectional study in a population-based sample of Japanese men aged 40 through 79 years. Areas of abdominal visceral adipose tissue (VAT) and subcutaneous adipose tissue (SAT) were calculated using computed tomography imaging. Based on a questionnaire, we classified participants into five groups according to weekly alcohol consumption, excluding former drinkers: non-drinkers (0 g/week), 0.1–160.9, 161–321.9, 322–482.9, and ≥483 g/week. Multivariable linear regression was used to estimate adjusted means of obesity indices for each group. Results: We analyzed 998 men (mean age and body mass index [BMI], 63.8 years and 23.6 kg/m2, respectively). Higher weekly alcohol consumption was strongly and significantly associated with higher abdominal VAT area, percentage of VAT, and VAT-to-SAT ratio (all P for trend

Published
2019

24. Relationship of Four Blood Pressure Indexes to Subclinical Cerebrovascular Diseases Assessed by Brain MRI in General Japanese Men

Author

Salman, Ebtehal, primary, Kadota, Aya, additional, Hisamatsu, Takashi, additional, Segawa, Hiroyoshi, additional, Torii, Sayuki, additional, Fujiyoshi, Akira, additional, Kondo, Keiko, additional, Watanabe, Yoshiyuki, additional, Arima, Hisatomi, additional, Shiino, Akihiko, additional, Nozaki, Kazuhiko, additional, Ueshima, Hirotsugu, additional, and Miura, Katsuyuki, additional

Published
2022
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25. A Comparison of Segment-Specific and Composite Measures of Carotid Intima-Media Thickness and their Relationships with Coronary Calcium

Author

Zaid, Maryam, primary, Fujiyoshi, Akira, additional, Hisamatsu, Takashi, additional, Kadota, Aya, additional, Kadowaki, Sayaka, additional, Satoh, Atsushi, additional, Sekikawa, Akira, additional, Barinas-Mitchell, Emma, additional, Horie, Minoru, additional, Miura, Katsuyuki, additional, and Ueshima, Hirotsugu, additional

Published
2022
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26. Cross-Sectional Comparison of Coronary Artery Calcium Scores Between Caucasian Men in the United States and Japanese Men in Japan: The Multi-Ethnic Study of Atherosclerosis and the Shiga Epidemiological Study of Subclinical Atherosclerosis

Author

Fujiyoshi, Akira, Miura, Katsuyuki, Ohkubo, Takayoshi, Kadowaki, Takashi, Kadowaki, Sayaka, Zaid, Maryam, Hisamatsu, Takashi, Sekikawa, Akira, Budoff, Matthew J., Liu, Kiang, Ueshima, Hirotsugu, Fujiyoshi, Akira, Miura, Katsuyuki, Ohkubo, Takayoshi, Kadowaki, Takashi, Kadowaki, Sayaka, Zaid, Maryam, Hisamatsu, Takashi, Ueshima, Hirotsugu, Miura, Katsuyuki, Hisamatsu, Takashi, Ueshima, Hirotsugu, Ohkubo, Takayoshi, Sekikawa, Akira, Budoff, Matthew J., and Liu, Kiang

Published
2014
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28. Differences Between Coronary Artery Calcification and Aortic Artery Calcification in Relation to Cardiovascular Disease Risk Factors in Japanese Men

Author

Kimani Cecilia, Kadota Aya, Miura Katsuyuki, Fujiyoshi Akira, Zaid Maryam, Kadowaki Sayaka, Hisamatsu Takashi, Arima Hisatomi, Horie Minoru, Ueshima Hirotsugu, Yamamoto Takashi, Maegawa Hiroshi, Murata Kiyoshi, Nozaki Kazuhiko, Shiino Akihiko, Toyama Ikuo, Tsuru Teruhiko, Ogita Hisakazu, Takashima Naoyuki, Kadowaki Takashi, Miyamatsu Naomi, Miyagawa Naoko, Torii Sayuki, Hayashi Hideki, Nakano Yasutaka, Ogawa Emiko, Miyazawa Itsuko, Shimizu Akio, Abbott Robert D., Kondo Keiko, Suzuki Sentaro, Ito Takahiro, Andoh Akira, Kunimura Ayako, Nishio Yoshihiko, Mitsunami Kenichi, Kita Toru, Kimura Takeshi, Tabara Yasuharu, Nakamura Yasuyuki, Okamura Tomonori, Sekikawa Akira, Barinas-Mitchell Emma J. M., Ohkubo Takayoshi, Kita Yoshikuni, Murakami Yoshitaka, Hozawa Atsushi, Okuda Nagako, Higashiyama Aya, Ohno Seiko, Nagasawa Shinya, Yamazo Masahiro, Saito Yoshino, Edmundowicz Daniel, Satoh Atsushi, Azuma Koichiro, Yanagita Masahiko, Sawamura Tatsuya, and Igase Michiya

Subjects
Adult, Male, medicine.medical_specialty, Aortic Diseases, Renal function, Blood lipids, Coronary Artery Disease, 030204 cardiovascular system & hematology, Coronary artery, Logistic regression, Calcification, 03 medical and health sciences, 0302 clinical medicine, Japan, Internal medicine, Internal Medicine, Humans, Medicine, cardiovascular diseases, Vascular Calcification, Generalized estimating equation, Aorta, Aged, 2. Zero hunger, business.industry, Incidence, Biochemistry (medical), nutritional and metabolic diseases, Odds ratio, Middle Aged, Prognosis, medicine.disease, Coronary Vessels, Aortic artery, Cardiovascular diseases, Risk factors, 3. Good health, Blood pressure, Cardiology, Original Article, Cardiology and Cardiovascular Medicine, business, Body mass index, 030217 neurology & neurosurgery, Follow-Up Studies
Abstract

Aims: Calcification in the coronary and aortic arteries has been linked to cardiovascular morbidity and mortality. The pathophysiological influence of aortic artery calcification (AAC) differs from that of coronary artery calcification (CAC). We aimed to compare the relationships between CAC and AAC and cardiovascular disease (CVD) risk factors. Methods: We examined a random sample of 1035 Japanese men aged 40–79 years. CAC and AAC were measured by computed tomography and scored according to the Agatston method. Using a logistic regression, we calculated the odds ratio (OR) as being in the highest quintile (Q5) of the calcification score compared to the lower quintiles (Q1–Q4) per 1 standard deviation higher CVD risk factor. Models were simultaneously adjusted for age, body mass index (BMI), systolic blood pressure, smoking (pack-year), alcohol intake, hemoglobin A1c, uric acid, estimated glomerular filtration rate (eGFR), serum lipids, and C-reactive protein. Differences in ORs were investigated using a generalized estimating equation. We performed a multiple linear regression using log-transformed CAC and AAC values as dependent variables. Results: CAC and AAC were independently associated with age (OR, 95% CI: 2.30 [1.77–2.98] for CAC and 3.48 [2.57–4.73] for AAC), p for difference < 0.001), systolic blood pressure (1.29 [1.08–1.53] and 1.28 [1.07–1.54], p for difference = 0.270), and smoking (1.22, [1.04–1.43] and 1.34 [1.13–1.58]) p for difference = 0.071). Alcohol correlated with AAC only (1.17 [0.97–1.41] for CAC and 1.42 [1.16–1.73] for AAC, p for difference = 0.020). Conclusions: CAC and AAC were associated with similar CVD risk factors. The strength of association slightly differed between CAC and AAC.

Published
2019

29. Abstract P096: Association Of Accurately Measured Office, Self-measured Home, And Ambulatory Blood Pressure And Their Variability With Intracranial Arterial Stenosis

Author

Hisamatsu, Takashi, primary, Ohkubo, Takayoshi, additional, Fujiyoshi, Akira, additional, Torii, Sayuki, additional, Segawa, Hiroyoshi, additional, Kondo, Keiko, additional, Kadota, Aya, additional, Takashima, Naoyuki, additional, Shitara, Satoshi, additional, Arima, Hisatomi, additional, Nakagawa, Yoshihisa, additional, Watanabe, Yoshiyuki, additional, Shiino, Akihiko, additional, Nozaki, Kazuhiko, additional, Ueshima, Hirotsugu, additional, and Miura, Katsuyuki, additional

Published
2021
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34. Association between Psychological Factors and Evacuation Status and the Incidence of Cardiovascular Diseases after the Great East Japan Earthquake: A Prospective Study of the Fukushima Health Management Survey

Author

Sanoh, Toshiki, primary, Eguchi, Eri, additional, Ohira, Tetsuya, additional, Hayashi, Fumikazu, additional, Maeda, Masaharu, additional, Yasumura, Seiji, additional, Suzuki, Yuriko, additional, Yabe, Hirooki, additional, Takahashi, Atsushi, additional, Takase, Kanae, additional, Harigane, Mayumi, additional, Hisamatsu, Takashi, additional, Ogino, Keiki, additional, Kanda, Hideyuki, additional, and Kamiya, Kenji, additional

Published
2020
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35. Cardiac Conduction Disorders as Markers of Cardiac Events in Myotonic Dystrophy Type 1

Author

Itoh, Hideki, primary, Hisamatsu, Takashi, additional, Tamura, Takuhisa, additional, Segawa, Kazuhiko, additional, Takahashi, Toshiaki, additional, Takada, Hiroto, additional, Kuru, Satoshi, additional, Wada, Chizu, additional, Suzuki, Mikiya, additional, Suwazono, Shugo, additional, Sasaki, Shingo, additional, Okumura, Ken, additional, Horie, Minoru, additional, Takahashi, Masanori P., additional, and Matumura, Tsuyoshi, additional

Published
2020
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36. Proteinuria and Reduced Estimated Glomerular Filtration Rate are Independently Associated With Lower Cognitive Abilities in Apparently Healthy Community-Dwelling Elderly Men in Japan: A Cross-sectional Study

Author

Fujiyoshi, Akira, primary, Miura, Katsuyuki, additional, Ohkubo, Takayoshi, additional, Miyagawa, Naoko, additional, Saito, Yoshino, additional, Miyazawa, Itsuko, additional, Shiino, Akihiko, additional, Kadota, Aya, additional, Kadowaki, Sayaka, additional, Hisamatsu, Takashi, additional, Torii, Sayuki, additional, Takashima, Naoyuki, additional, Tooyama, Ikuo, additional, and Ueshima, Hirotsugu, additional

Published
2020
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37. Elevated Fasting Blood Glucose Levels Are Associated With Lower Cognitive Function, With a Threshold in Non-Diabetic Individuals: A Population-Based Study

Author

Liu, Ziyi, primary, Zaid, Maryam, additional, Hisamatsu, Takashi, additional, Tanaka, Sachiko, additional, Fujiyoshi, Akira, additional, Miyagawa, Naoko, additional, Ito, Takahiro, additional, Kadota, Aya, additional, Tooyama, Ikuo, additional, Miura, Katsuyuki, additional, and Ueshima, Hirotsugu, additional

Published
2020
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39. Lipoprotein particles and coronary artery calcium in middle-aged US-White and Japanese men

Author

Mahajan, Hemant, primary, Zaid, Maryam, additional, Mackey, Rachel, additional, Kadota, Aya, additional, Vishnu, Abhishek, additional, Fujiyoshi, Akira, additional, Vasudha, Ahuja, additional, Hisamatsu, Takashi, additional, Evans, Rhobert, additional, Okamura, Tomonori, additional, Miura, Katsuyuki, additional, Kuller, Lewis, additional, Ueshima, Hirotsugu, additional, and Sekikawa, Akira, additional

Published
2019
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40. Coronary Artery Calcification for Prevention of Atherosclerotic Cardiovascular Disease

Author

Hisamatsu, Takashi

Subjects
primary prevention, nutritional and metabolic diseases, atherosclerotic cardiovascular disease, epidemiology, cardiovascular diseases, coronary artery calcification
Abstract

Atherosclerotic cardiovascular disease （ASCVD）,including coronary heart disease, remains a major cause of death and disability among developed countries. Coronary artery calcification （CAC）, which is detected by computed tomography scanning, is a well-known measure of subclinical atherosclerosis. CAC is considered to have important implications for understanding the long-term accumulated burden of cardiovascular risk factors and for the possibility of reclassification at the preclinical phase for preventing ASCVD. This review focuses on CAC and its usability in primary prevention of ASCVD. Numerous epidemiological studies, mainly in Western countries, have indicated that, among asymptomatic individuals, the CAC score is associated with future ASCVD. Additionally, the CAC score provides improved predictive values for estimating the risk of ASCVD beyond traditional cardiovascular risk factors. However, a lack of evidence for this score in other populations warrants further investigations. Clinical trials are also necessary to demonstrate the usefulness and safety of CAC screening for primary prevention of ASCVD.

Published
2017

41. Liver fat accumulation assessed by computed tomography is an independent risk factor for diabetes mellitus in a population-based study: SESSA (Shiga Epidemiological Study of Subclinical Atherosclerosis)

Author

FUSE, Keiko, KADOTA, Aya, KONDO, Keiko, MORINO, Katsutaro, FUJIYOSHI, Akira, HISAMATSU, Takashi, KADOWAKI, Sayaka, MIYAZAWA, Itsuko, UGI, Satoshi, MAEGAWA, Hiroshi, MIURA, Katsuyuki, UESHIMA, Hirotsugu, and Shiga, Epidemiological Study of Subclinical Atherosclerosis (SESSA) Research Group

Subjects
Male, medicine.medical_specialty, Endocrinology, Diabetes and Metabolism, Population, 030209 endocrinology & metabolism, Gastroenterology, 03 medical and health sciences, 0302 clinical medicine, Endocrinology, Insulin resistance, Diabetes mellitus, Risk Factors, Internal medicine, Fatty liver, Internal Medicine, medicine, Humans, 030212 general & internal medicine, Longitudinal Studies, Prospective Studies, Risk factor, education, education.field_of_study, business.industry, Incidence (epidemiology), General Medicine, Odds ratio, Middle Aged, medicine.disease, Confidence interval, Epidemiologic Studies, Diabetes Mellitus, Type 2, Female, business, Tomography, X-Ray Computed, CT
Abstract

AIMS:Ectopic fat accumulation is related to insulin resistance and diabetes mellitus (DM). However, the effect of fatty liver on DM in non-obese individuals has not been clarified. We investigated whether liver fat accumulation assessed by computed tomography (CT) is associated with the incidence of DM., METHODS:In a prospective population-based study, 640 Japanese men were followed up for 5 years. The liver to spleen (L/S) ratio of the CT attenuation value was used as the liver fat accumulation index. We calculated the odds ratio (OR) and 95% confidence interval (CI) for the DM incidence of per 1 standard deviation (SD) lower L/S and those of L/S < 1.0 compared with L/S ≥ 1.0, using logistic regression models., RESULTS:Both per 1 SD lower L/S and L/S < 1.0 were significantly associated with a risk for DM incidence (1 SD lower L/S: OR = 1.57, 95%CI = 1.14-2.16; L/S < 1.0: OR = 2.27, 95%CI = 1.00-5.14). The relationship between L/S and incidence of DM was consistent in the obese and non-obese groups, with thresholds of BMI 25 kg/m2, waist circumference 85 cm, or visceral adipose tissue 100 cm2., CONCLUSIONS:Liver fat accumulation assessed by CT was associated with the incidence of DM.

Published
2020

42. Abstract P009: Association Between Intracranial Subclinical Vessel Diseases and Cognition in a Community-Based Sample of Japanese Men: Shiga Epidemiological Study of Subclinical Atherosclerosis (SESSA)

Author

Ito, Takahiro, primary, Fujiyoshi, Akira, additional, Ohkubo, Takayoshi, additional, Shiino, Akihiko, additional, Nozaki, Kazuhiko, additional, Miyagawa, Naoko, additional, Torii, Sayuki, additional, Hisamatsu, Takashi, additional, Miura, Katsuyuki, additional, and Ueshima, Hirotsugu, additional

Published
2019
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47. Data on alcohol consumption and coronary artery calcification among asymptomatic middle-aged men for the ERA-JUMP study

Author

Mahajan, Hemant, primary, Choo, Jina, additional, Masaki, Kamal, additional, Fujiyoshi, Akira, additional, Guo, Jingchuan, additional, Hisamatsu, Takashi, additional, Evans, Rhobert, additional, Shangguan, Siyi, additional, Willcox, Bradley, additional, Okamura, Tomonori, additional, Vishnu, Abhishek, additional, Barinas-Mitchell, Emma, additional, Ahuja, Vasudha, additional, Miura, Katsuyuki, additional, Kuller, Lewis, additional, Shin, Chol, additional, Ueshima, Hirotsugu, additional, and Sekikawa, Akira, additional

Published
2018
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50. Abstract P014: Lower eGFR and Proteinuria Were Independently Associated With Lower Cognitive Abilities in Community-dwelling Men in Japan: SESSA study

Author

Fujiyoshi, Akira, primary, Ohkubo, Takayoshi, additional, Miura, Katsuyuki, additional, Shiino, Akihiko, additional, Miyagawa, Naoko, additional, Takashima, Naoyuki, additional, Saitoh, Yoshino, additional, Torii, Sayuki, additional, Kadota, Aya, additional, Kadowaki, Sayaka, additional, Hisamatsu, Takashi, additional, Miyazawa, Itsuko, additional, Tooyama, Ikuo, additional, and Ueshima, Hirotsugu, additional

Published
2017
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