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4 results on '"George L van Driem"'

1. A linguistically informed autosomal STR survey of human populations residing in the greater Himalayan region.

Author

Thirsa Kraaijenbrink, Kristiaan J van der Gaag, Sofia B Zuniga, Yali Xue, Denise R Carvalho-Silva, Chris Tyler-Smith, Mark A Jobling, Emma J Parkin, Bing Su, Hong Shi, Chun-Jie Xiao, Wen-Ru Tang, V K Kashyap, R Trivedi, T Sitalaximi, Jheelam Banerjee, Karma Tshering of Gaselô, Nirmal M Tuladhar, Jean-Robert M L Opgenort, George L van Driem, Guido Barbujani, and Peter de Knijff

Subjects
Medicine, Science
Abstract

The greater Himalayan region demarcates two of the most prominent linguistic phyla in Asia: Tibeto-Burman and Indo-European. Previous genetic surveys, mainly using Y-chromosome polymorphisms and/or mitochondrial DNA polymorphisms suggested a substantially reduced geneflow between populations belonging to these two phyla. These studies, however, have mainly focussed on populations residing far to the north and/or south of this mountain range, and have not been able to study geneflow patterns within the greater Himalayan region itself. We now report a detailed, linguistically informed, genetic survey of Tibeto-Burman and Indo-European speakers from the Himalayan countries Nepal and Bhutan based on autosomal microsatellite markers and compare these populations with surrounding regions. The genetic differentiation between populations within the Himalayas seems to be much higher than between populations in the neighbouring countries. We also observe a remarkable genetic differentiation between the Tibeto-Burman speaking populations on the one hand and Indo-European speaking populations on the other, suggesting that language and geography have played an equally large role in defining the genetic composition of present-day populations within the Himalayas.

Published
2014
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2. Allele frequency distribution for 21 autosomal STR loci in Bhutan

Author

Thirsa Kraaijenbrink, George L. van Driem, Karma Tshering of Gaselô, and Peter de Knijff

Subjects
Genetics, Heterozygote, Biology, DNA Fingerprinting, Polymerase Chain Reaction, Pathology and Forensic Medicine, Genetics, Population, Gene Frequency, Tandem Repeat Sequences, Multiplex polymerase chain reaction, Population data, Str loci, Humans, Microsatellite, Allele, Bhutan, Law, Allele frequency
Abstract

The allele frequency distributions of 21 autosomal loci contained in the AmpFlSTR 1 Identifiler TM , the Powerplex 1 16 and the FFFL 1 multiplex PCR kits, was studied in 953 unrelated individuals from Nepal. Several new alleles (i.e. not yet reported in the NIST Short Tandem Repeat DNA Internet DataBase [http://www.cstl.nist.gov/biotech/strbase/]) have been detected in the process. # 2006 Elsevier Ireland Ltd. All rights reserved.

Published
2007
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3. 26-Locus Y-STR typing in a Bhutanese population sample

Author

Emma J. Parkin, Thirsa Kraayenbrink, George L. van Driem, Karma Tshering of Gaselô, Peter de Knijff, and Mark A. Jobling

Subjects
Male, Genetics, education.field_of_study, Chromosomes, Human, Y, Amelogenin, STR multiplex system, Population, Haplotype, Locus (genetics), Biology, DNA Fingerprinting, Polymerase Chain Reaction, Pathology and Forensic Medicine, Genetics, Population, Dental Enamel Proteins, Gene Frequency, DNA profiling, Tandem Repeat Sequences, Multiplex polymerase chain reaction, Humans, Y-STR, Multiplex, Bhutan, education, Law
Abstract

26 Y chromosome short tandem repeat (STR) loci were amplified in a sample of 856 unrelated males from Bhutan, using two multiplex polymerase chain reaction (PCR) assays. The first multiplex is the Y-STR 20plex described by Butler et al. [J.M. Butler, R. Schoske, P.M. Vallone, M.C. Kline, A.J. Redd, M.F. Hammer, A novel multiplex for simultaneous amplification of 20 Y chromosome STR markers, Forensic Sci. Int. 129 (2002) 10-24], and the second is a novel (but overlapping) 14plex that targets six additional Y-STRs (DYS425, DYS434, DYS435, DYS436, DYS461, DYS462) and also amplifies the amelogenin locus. The 26-loci give a discriminating power of 0.9957, though even at this resolution one haplotype occurs 24 times. We identify novel alleles at five loci and microvariants at a further three, which were characterised by sequencing. Extended (11-locus) haplotypes for these samples have been submitted to the Y-STR Haplotype Reference Database (YHRD).

Published
2006
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