1. Golgi complex fragmentation in G2/M transition: An organelle-based cell-cycle checkpoint
- Author
-
Maria Luisa Barretta, Romina Ines Cervigni, Antonino Colanzi, and Daniela Corda
- Subjects
G2 Phase ,Cell cycle checkpoint ,Cell division ,Clinical Biochemistry ,Golgi Apparatus ,Mitosis ,Biology ,Biochemistry ,symbols.namesake ,Organelle ,Genetics ,Animals ,Humans ,Fragmentation (cell biology) ,Molecular Biology ,Golgi Matrix Proteins ,Membrane Proteins ,Intracellular Membranes ,Cell Biology ,Cell cycle ,Golgi apparatus ,Rats ,Cell biology ,Golgi ribbon ,cell cycle ,mitosis ,membranes ,organelles ,CtBP1-S/BARS ,GRASP-55 ,GRASP-65 ,DNA-Binding Proteins ,Repressor Proteins ,Alcohol Oxidoreductases ,Golgi disassembly ,symbols ,Carrier Proteins ,HeLa Cells - Abstract
In mammalian cells, the Golgi complex is organized into a continuous membranous system known as the Golgi ribbon, which is formed by individual Golgi stacks that are laterally connected by tubular bridges. During mitosis, the Golgi ribbon undergoes extensive fragmentation through a multistage process that is required for its correct partitioning into the daughter cells. Importantly, inhibition of this Golgi disassembly results in cell-cycle arrest at the G2 stage, suggesting that accurate inheritance of the Golgi complex is monitored by a "Golgi mitotic checkpoint." Here, we discuss the mechanisms and regulation of the Golgi ribbon breakdown and briefly comment on how Golgi partitioning may inhibit G2/M transition.
- Published
- 2012