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Golgi complex fragmentation in G2/M transition: An organelle-based cell-cycle checkpoint
- Source :
- IUBMB life, 64 (2012): 661–670. doi:10.1002/iub.1054, info:cnr-pdr/source/autori:Corda D, Barretta ML, Cervigni RI, Colanzi A./titolo:Golgi complex fragmentation in G2%2FM transition: An organelle-based cell-cycle checkpoint/doi:10.1002%2Fiub.1054/rivista:IUBMB life (Print)/anno:2012/pagina_da:661/pagina_a:670/intervallo_pagine:661–670/volume:64
- Publication Year :
- 2012
- Publisher :
- Wiley, 2012.
-
Abstract
- In mammalian cells, the Golgi complex is organized into a continuous membranous system known as the Golgi ribbon, which is formed by individual Golgi stacks that are laterally connected by tubular bridges. During mitosis, the Golgi ribbon undergoes extensive fragmentation through a multistage process that is required for its correct partitioning into the daughter cells. Importantly, inhibition of this Golgi disassembly results in cell-cycle arrest at the G2 stage, suggesting that accurate inheritance of the Golgi complex is monitored by a "Golgi mitotic checkpoint." Here, we discuss the mechanisms and regulation of the Golgi ribbon breakdown and briefly comment on how Golgi partitioning may inhibit G2/M transition.
- Subjects :
- G2 Phase
Cell cycle checkpoint
Cell division
Clinical Biochemistry
Golgi Apparatus
Mitosis
Biology
Biochemistry
symbols.namesake
Organelle
Genetics
Animals
Humans
Fragmentation (cell biology)
Molecular Biology
Golgi Matrix Proteins
Membrane Proteins
Intracellular Membranes
Cell Biology
Cell cycle
Golgi apparatus
Rats
Cell biology
Golgi ribbon
cell cycle
mitosis
membranes
organelles
CtBP1-S/BARS
GRASP-55
GRASP-65
DNA-Binding Proteins
Repressor Proteins
Alcohol Oxidoreductases
Golgi disassembly
symbols
Carrier Proteins
HeLa Cells
Subjects
Details
- ISSN :
- 15216543
- Volume :
- 64
- Database :
- OpenAIRE
- Journal :
- IUBMB Life
- Accession number :
- edsair.doi.dedup.....245df16427e3ae3f48218ddd979d7076