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2. Whole genome sequencing of Trypanosoma cruzi field isolates reveals extensive genomic variability and complex aneuploidy patterns within TcII DTU

Author

Reis-Cunha, João Luís, Baptista, Rodrigo P., Rodrigues-Luiz, Gabriela F., Coqueiro-dos-Santos, Anderson, Valdivia, Hugo O., de Almeida, Laila Viana, Cardoso, Mariana Santos, D’Ávila, Daniella Alchaar, Dias, Fernando Hugo Cunha, Fujiwara, Ricardo Toshio, Galvão, Lúcia M. C., Chiari, Egler, Cerqueira, Gustavo Coutinho, and Bartholomeu, Daniella C.

Published
2018
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3. Trypanosoma cruzi as an effective cancer antigen delivery vector

Author

Junqueira, Caroline, Santos, Luara I., Galvão-Filho, Bruno, Teixeira, Santuza M., Rodrigues, Flávia G., DaRocha, Wanderson D., Chiari, Egler, Jungbluth, Achim A., Ritter, Gerd, Gnjatic, Sacha, Old, Lloyd J., and Gazzinelli, Ricardo T.

Published
2011

4. Novel Derivatives of Kaurenoic Acid

Author

Vieira Henriete S., Takahashi Jacqueline A., Oliveira Alaíde B. de, Chiari Egler, and Boaventura Maria Amélia D.

Subjects
kaurenoic acid, kaurenic hydrochloride salts, kauranic oximes, trypanocidal activity, Chemistry, QD1-999
Abstract

Kaurenoic acid, a kauranic diterpenoid, presents in vitro activity against trypomastigote forms of Trypanosoma cruzi, showing, however, lytic activity on blood erythrocytes, as a side effect. The syntheses of twelve new derivatives of kaurenoic acid, four amides, four amines (and three hydroclorides) and four oximes, was carried out aiming at the improvement of the therapeutic activity and without the side effect. Among the derivatives prepared, one compound showed enhanced trypanocidal activity in vitro towards Trypanosoma cruzi trypomastigote erythrocytic forms, when compared to kaurenoic acid, but continued to show discrete lytic activity on erythrocytes; another compound showed a level of activity similar to that of kaurenoic acid, but without lysis.

Published
2002

5. Aminoquinolone WR6026 as a feasible substitute for gentian violet in Chagas' disease prophylaxis in preserved blood for transfusional purposes

Author

Moraes-Souza Helio, Pianetti Gisele Marilia, Barretto Orlando César de Oliveira Pereira, Nonoyama Kimyo, Grolg M., and Chiari Egler

Subjects
Transfusion-associated Chagas' disease, Chemoprophylaxis, Aminoquinolone, Blood transfusion, Arctic medicine. Tropical medicine, RC955-962
Abstract

The search for a colorless, nontoxic and efficient drug to prevent transfusion-associated Chagas' disease (TACD) has been underway unsuccessfully since 1953 when gentian violet was preconized and to date is still being used as the only in vitro trypanocidal agent. The recent findings of aminoquinolone "WR6026" as a trypanocidal agent, led the authors to study the metabolism of red cells stored with this compound, the main objective of which was to define its applicability in TACD control. Ten units of human whole blood collected in CPDA-1 were divided into two equal satellite bags. One had "WR6026" (final concentration 62.5µg/mL) added and the other was used as a control, both were stored at 4ºC. At baseline, day 7, 14, 21 and 28, samples were taken for the following measurements: adenosine triphosphate (ATP), hemoglobin, electrolytes (sodium and potassium), gases (pO2 and pCO2) and osmotic fragility. The results of tests and control were analyzed through parametric t-student test. The results were similar in both groups throughout the experiment except for the level of ATP on day 14, which presented significantly higher values in the tests when compared with the controls (p = 0.012). It was concluded that WR6026 does not interfere in the preservation and probably the viability of the erythrocytes also until day 28 of storage. Consequently the authors suggest that WR6026 could emerge as a colorless substitute for gentian violet in the control of TACD in endemic areas.

Published
2002

6. Usefulness of microsatellite typing in population genetic studies of Trypanosoma cruzi

Author

Macedo Andrea M, Pimenta Juliana R, Aguiar Renato S de, Melo Anna Izabel R, Chiari Egler, Zingales Bianca, Pena Sérgio DJ, and Oliveira Riva P

Subjects
Trypanosoma cruzi, microsatellites, genetic typing, rDNA classification, phylogenetic inference, Microbiology, QR1-502, Infectious and parasitic diseases, RC109-216
Abstract

Through microsatellite analysis of 53 monoclonal populations of Trypanosoma cruzi, we found a remarkable degree of genetic polymorphism with no single multilocus genotype being observed more than once. The microsatellite profile proved to be stable during 70 generations of the CL Brener clone in culture. The microsatellite profiling presented also high diagnostic sensitivity since DNA amplifications could be achieved with less than 100 fg DNA, corresponding to half parasite total DNA content. Based on these technical attributes the microsatellite assay turns out to be an important tool for direct typing T. cruzi in biological samples. By using this approach we were able to type T. cruzi in feces of artificially infected bugs and in single cells sorted by FACS. The microsatellites have shown to be excellent markers for T. cruzi phylogenetic reconstruction. We used maximum parsimony based on the minimum number of mutational steps to build an unrooted Wagner network, which confirms previous conclusions based on the analysis of the D7 domain of the LSU rDNA gene that T. cruzi is composed by two major groups. We also obtained evidence that strains belonging to rRNA group 2 are subdivided into two genetically distant clusters, and that one of these clusters is more related to rRNA group 1/2. These results suggest different origins for these strains.

Published
2001

7. α-Gal immunization positively impacts Trypanosoma cruzi colonization of heart tissue in a mouse model

Author

Rodrigues da Cunha, Gisele Macêdo, primary, Azevedo, Maíra Araújo, additional, Nogueira, Denise Silva, additional, Clímaco, Marianna de Carvalho, additional, Valencia Ayala, Edward, additional, Jimenez Chunga, Juan Atilio, additional, La Valle, Raul Jesus Ynocente, additional, da Cunha Galvão, Lucia Maria, additional, Chiari, Egler, additional, Brito, Carlos Ramon Nascimento, additional, Soares, Rodrigo Pedro, additional, Nogueira, Paula Monalisa, additional, Fujiwara, Ricardo Toshio, additional, Gazzinelli, Ricardo, additional, Hincapie, Robert, additional, Chaves, Carlos-Sanhueza, additional, Oliveira, Fabricio Marcus Silva, additional, Finn, M. G., additional, and Marques, Alexandre Ferreira, additional

Published
2021
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8. Inter-relações entre os ciclos de transmissão do Trypanosoma cruzi no município de Bambuí, Minas Gerais, Brasil

Author

Fernandes Alexandre José, Diotaiuti Liléia, Dias João Carlos P., Romanha Álvaro José, and Chiari Egler

Subjects
Doença de Chagas, Trypanosoma cruzi, Ciclos de Transmissão, Reservatórios, Zimodema, Medicine, Public aspects of medicine, RA1-1270
Abstract

Neste trabalho apresentamos um estudo das inter-relações recentes entre os ciclos de transmissão silvestre e doméstico do T. cruzi no município de Bambuí, Minas Gerais, Brasil. No final da década de 1930, o Panstrongylus megistus era encontrado em 75% das casas. Subseqüentemente, o Triatoma infestans tornou-se a espécie predominante, sendo encontrada em 20% das residências urbanas e em mais de 60% das periurbanas. Com as intensas campanhas de borrifação desenvolvidas entre 1956 e 1969, o T. infestans foi erradicado do município, e a transmissão da doença de Chagas ao homem, interrompida, com aparecimento de P. megistus em residências rurais. Amostras de T. cruzi isoladas via xenodiagnóstico e hemocultura de 43 gambás (Didelphis albiventris) capturados em ambiente peridomiciliar e silvestre foram caracterizadas isoenzimaticamente e, independentemente da via de isolamento, apresentaram perfil de zimodema Z1. Por meio do Programa de Vigilância Epidemiológica da doença de Chagas, no período de agosto de 1986 a dezembro de 1988, 154 exemplares de P. megistus foram capturados pela população no peridomicílio e intradomicílio rural, estando 9,8% infectados pelo T. cruzi. Na caracterização isoenzimática de 13 amostras de T. cruzi isoladas desses triatomíneos, seis pertenciam ao zimodema Z1 (ciclo de transmissão silvestre), e sete ao Z2 (ciclo de transmissão doméstico). A captura de exemplares de P. megistus no intradomicílio, naturalmente infectados com parasitas de ambos os ciclos, indica a superposição dos ciclos de transmissão da doença de Chagas no município de Bambuí. Outra evidência da inter-relação dos ciclos pôde ser observada no isolamento de T. cruzi Z2 de um gato e a participação do cão como reservatório de T. cruzi Z1. A presença do P. megistus no peridomicílio representa importante elo entre o ambiente silvestre e o intradomicílio, servindo como veiculador do T. cruzi Z1 e na manutenção de ciclos de transmissão do T. cruzi Z2 no peridomicílio e domicílio, propiciando de forma gradual a reinfestação do município caso a Vigilância Epidemiológica seja interrompida.

Published
1994

12. NOD2 receptor is crucial for protecting against the digestive form of Chagas disease

Author

Pereira, Nathalie de Sena, primary, Queiroga, Tamyres Bernadete Dantas, additional, da Silva, Denis Dantas, additional, Nascimento, Manuela Sales Lima, additional, Andrade, Cléber Mesquita de, additional, Souto, Janeusa Trindade de, additional, Ricci, Mayra Fernanda, additional, Arantes, Rosa Maria Esteves, additional, Zamboni, Dario Simões, additional, Chiari, Egler, additional, Câmara, Antônia Cláudia Jácome da, additional, Galvão, Lúcia Maria da Cunha, additional, and Guedes, Paulo Marcos Matta, additional

Published
2020
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13. Differential Modulation of Mouse Heart Gene Expression by Infection With Two Trypanosoma cruzi Strains: A Transcriptome Analysis

Author

Castro, Tiago Bruno Rezende de, primary, Canesso, Maria Cecilia Campos, additional, Boroni, Mariana, additional, Chame, Daniela Ferreira, additional, Souza, Daniela de Laet, additional, Toledo, Nayara Evelin de, additional, Tahara, Eric Birelli, additional, Pena, Sergio Danilo, additional, Machado, Carlos Renato, additional, Chiari, Egler, additional, Macedo, Andrea, additional, and Franco, Gloria Regina, additional

Published
2020
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15. Comparison of phenol-chloroform and a commercial deoxyribonucleic acid extraction kit for identification of bloodmeal sources from triatomines (Hemiptera: Reduviidae)

Author

Silva, Andressa Noronha Barbosa da, primary, Souza, Rita de Cássia Moreira de, additional, Honorato, Nathan Ravi Medeiros, additional, Martins, Rand Randall, additional, Câmara, Antônia Claudia Jácome da, additional, Galvão, Lúcia Maria da Cunha, additional, and Chiari, Egler, additional

Published
2020
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16. First report of Psammolestes tertius Lent & Jurberg, 1965 (Hemiptera, Reduviidae, Triatominae) in Rio Grande do Norte state, Brazil

Author

Noronha Barbosa da Silva, Andressa, Diotaiuti, Liléia, Jácome da Câmara, Antonia Claudia, Câmara de Oliveira, Pedro Igor, Cunha Galvão , Lúcia Maria, Chiari , Egler, and Moreira de Souza, Rita de Cássia

Subjects
Chagas disease, conservation units, caatinga, geographical distribution, ecological station, vector
Abstract

We report the first known occurrence of Psammolestes tertius Lent & Jurberg, 1965 (Hemiptera, Reduviidae, Triatominae) in the state of Rio Grande do Norte, Brazil. In 2009 and 2017, 2 adult specimens, a female and a male respectively, were collected at the Seridó Ecological Station, which is located in the municipality of Serra Negra do Norte. These records broadens the geographical distribution of P. tertius in Brazil and the biodiversity of triatomines in Rio Grande do Norte.

Published
2018

18. Synanthropic triatomines (Hemiptera: Reduviidae): infestation, colonization, and natural infection by trypanosomatids in the State of Rio Grande do Norte, Brazil

Author

Barbosa-Silva, Andressa Noronha, primary, Souza, Rita de Cássia Moreira de, additional, Diotaiuti, Liléia, additional, Aguiar, Lúcia Maria Abrantes, additional, Câmara, Antonia Cláudia Jácome da, additional, Galvão, Lúcia Maria da Cunha, additional, and Chiari, Egler, additional

Published
2019
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21. Innate immune receptors over expression correlate with chronic chagasic cardiomyopathy and digestive damage in patients

Author

Pereira, Nathalie de Sena, primary, Queiroga, Tamyres Bernadete Dantas, additional, Nunes, Daniela Ferreira, additional, Andrade, Cléber de Mesquita, additional, Nascimento, Manuela Sales Lima, additional, Do-Valle-Matta, Maria Adelaide, additional, Câmara, Antônia Cláudia Jácome da, additional, Galvão, Lúcia Maria da Cunha, additional, Guedes, Paulo Marcos Matta, additional, and Chiari, Egler, additional

Published
2018
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25. 2 nd Brazilian Consensus on Chagas Disease, 2015

Author

Dias, João Carlos Pinto, primary, Ramos Jr., Alberto Novaes, additional, Gontijo, Eliane Dias, additional, Luquetti, Alejandro, additional, Shikanai-Yasuda, Maria Aparecida, additional, Coura, José Rodrigues, additional, Torres, Rosália Morais, additional, Melo, José Renan da Cunha, additional, Almeida, Eros Antonio de, additional, Oliveira Jr., Wilson de, additional, Silveira, Antônio Carlos, additional, Rezende, Joffre Marcondes de, additional, Pinto, Fabiane Scalabrini, additional, Ferreira, Antonio Walter, additional, Rassi, Anis, additional, Fragata Filho, Abílio Augusto, additional, Sousa, Andréa Silvestre de, additional, Correia, Dalmo, additional, Jansen, Ana Maria, additional, Andrade, Glaucia Manzan Queiroz, additional, Britto, Constança Felícia De Paoli de Carvalho, additional, Pinto, Ana Yecê das Neves, additional, Rassi Jr., Anis, additional, Campos, Dayse Elisabeth, additional, Abad-Franch, Fernando, additional, Santos, Silvana Eloi, additional, Chiari, Egler, additional, Hasslocher-Moreno, Alejandro Marcel, additional, Moreira, Eliane Furtado, additional, Marques, Divina Seila de Oliveira, additional, Silva, Eliane Lages, additional, Marin-Neto, José Antonio, additional, Galvão, Lúcia Maria da Cunha, additional, Xavier, Sergio Salles, additional, Valente, Sebastião Aldo da Silva, additional, Carvalho, Noêmia Barbosa, additional, Cardoso, Alessandra Viana, additional, Silva, Rafaella Albuquerque e, additional, Costa, Veruska Maia da, additional, Vivaldini, Simone Monzani, additional, Oliveira, Suelene Mamede, additional, Valente, Vera da Costa, additional, Lima, Mayara Maia, additional, and Alves, Renato Vieira, additional

Published
2016
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26. II Consenso Brasileiro em Doença de Chagas, 2015

Author

Carlos Pinto Dias, João, primary, Novaes Ramos, Alberto, additional, Dias Gontijo, Eliane, additional, Luquetti, Alejandro, additional, Aparecida Shikanai-Yasuda, Maria, additional, Rodrigues Coura, José, additional, Morais Torres, Rosália, additional, Renan da Cunha Melo, José, additional, Antonio de Almeida, Eros, additional, de Oliveira Jr, Wilson, additional, Carlos Silveira, Antônio, additional, Marcondes de Rezende, Joffre, additional, Scalabrini Pinto, Fabiane, additional, Walter Ferreira, Antonio, additional, Rassi, Anis, additional, Augusto Fragata Filho, Abílio, additional, Silvestre de Sousa, Andréa, additional, Correia Filho, Dalmo, additional, Maria Jansen, Ana, additional, Manzan Queiroz Andrade, Glaucia, additional, Felícia De Paoli de Carvalho Britto, Constança, additional, Yecê das Neves Pinto, Ana, additional, Rassi Jr, Anis, additional, Elisabeth Campos, Dayse, additional, Abad-Franch, Fernando, additional, Eloi Santos, Silvana, additional, Chiari, Egler, additional, Marcel Hasslocher-Moreno, Alejandro, additional, Furtado Moreira, Eliane, additional, Seila de Oliveira Marques, Divina, additional, Lages Silva, Eliane, additional, Antonio Marin-Neto, José, additional, Maria da Cunha Galvão, Lúcia, additional, Salles Xavier, Sergio, additional, Aldo da Silva Valente, Sebastião, additional, Barbosa Carvalho, Noêmia, additional, Viana Cardoso, Alessandra, additional, Albuquerque e Silva, Rafaella, additional, Maia da Costa, Veruska, additional, Monzani Vivaldini, Simone, additional, Mamede Oliveira, Suelene, additional, da Costa Valente, Vera, additional, Maia Lima, Mayara, additional, and Vieira Alves, Renato, additional

Published
2016
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27. Inflammation Enhances the Risks of Stroke and Death in Chronic Chagas Disease Patients

Author

Guedes, Paulo Marcos Matta, primary, Andrade, Cléber Mesquita de, additional, Nunes, Daniela Ferreira, additional, de Sena Pereira, Nathalie, additional, Queiroga, Tamyres Bernadete Dantas, additional, Machado-Coelho, George Luiz Lins, additional, Nascimento, Manuela Sales Lima, additional, Do-Valle-Matta, Maria Adelaide, additional, Câmara, Antônia Cláudia Jácome da, additional, Chiari, Egler, additional, and Galvão, Lúcia Maria da Cunha, additional

Published
2016
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28. Alterações hematológicas durante a infecção canina experimental por Trypanosoma cruzi

Author

Guedes,Paulo Marcos Matta, Veloso,Vanja Maria, Mineo,Tiago Wilson Patriarca, Santiago-Silva,Juliana, Crepalde,Geovan, Caldas,Ivo Santana, Nascimento,Manuela Sales Lima, Lana,Marta, Chiari,Egler, Galvão,Lúcia Maria da Cunha, and Bahia,Maria Terezinha

Subjects
leukocytosis, Trypanosoma cruzi, Beagle dogs, leucocitose, parasitic diseases, linfocitose, parasitemia, cães Beagle, lymphocytosis, anemia
Abstract

To confirm that Beagle dogs are a good experimental model for Chagas disease, we evaluated hematological alterations during the acute and chronic phases in Beagle dogs infected with the Y, Berenice-78 (Be-78) and ABC strains of Trypanosomacruzi, correlating clinical signs with the parasitemia curve. We demonstrate that the acute phase of infection was marked by lethargy and loss of appetite. Simultaneously, we observed anemia, leukocytosis and lymphocytosis. Also,we describe hematological alterations and clinical signs that were positively correlated with the parasitemia during the experimental infection with the three strains of T.cruzi, and demonstrate that experimental infection of Beagle is a trustworthy model for Chagas disease. Para confirmar que cães Beagle são um bom modelo para doença de Chagas, foram avaliadas as alterações hematológicas durante as fases aguda e crônica em cães Beagle infectados com as cepas Y, Berenice-78 (Be-78) e ABC de Trypanosomacruzi, correlacionando os sinais clínicos com a curva de parasitemia. Foi demonstrado que a fase aguda da infecção foi marcada por letargia e perda de apetite. Simultaneamente, observou-se anemia, leucocitose e linfocitose. Ainda, foram descritas alterações hematológicas e sinais clínicos positivamente correlacionados com a parasitemia durante a infecção experimental com as três cepas de T.cruzi estudadas, demonstrando que a infecção em cães Beagle constitui um modelo fidedigno para a doença de Chagas.

Published
2012

29. Hematological alterations during experimental canine infection by Trypanosoma cruzi

Author

Guedes, Paulo Marcos da Matta, Veloso, Vanja Maria, Mineo, Tiago Wilson Patriarca, Silva, Juliana Santiago, Crepalde, Geovam Pereira, Caldas, Ivo Santana, Nascimento, Manuela Sales Lima, Lana, Marta de, Chiari, Egler, Galvão, Lúcia Maria da Cunha, and Bahia, Maria Terezinha

Subjects
Trypanosoma cruzi, Beagle dogs, parasitic diseases, Lymphocytosis, Parasitemia
Abstract

Para confirmar que cães Beagle são um bom modelo para doença de Chagas, foram avaliadas as alterações hematológicas durante as fases aguda e crônica em cães Beagle infectados com as cepas Y, Berenice-78 (Be-78) e ABC de Trypanosoma cruzi, correlacionando os sinais clínicos com a curva de parasitemia. Foi demonstrado que a fase aguda da infecção foi marcada por letargia e perda de apetite. Simultaneamente, observou-se anemia, leucocitose e linfocitose. Ainda, foram descritas alterações hematológicas e sinais clínicos positivamente correlacionados com a parasitemia durante a infecção experimental com as três cepas de T. cruzi estudadas, demonstrando que a infecção em cães Beagle constitui um modelo fidedigno para a doença de Chagas. To confirm that Beagle dogs are a good experimental model for Chagas disease, we evaluated hematological alterations during the acute and chronic phases in Beagle dogs infected with the Y, Berenice-78 (Be-78) and ABC strains of Trypanosoma cruzi, correlating clinical signs with the parasitemia curve. We demonstrate that the acute phase of infection was marked by lethargy and loss of appetite. Simultaneously, we observed anemia, leukocytosis and lymphocytosis. Also,we describe hematological alterations and clinical signs that were positively correlated with the parasitemia during the experimental infection with the three strains of T. cruzi, and demonstrate that experimental infection of Beagle is a trustworthy model for Chagas disease.

Published
2012

30. Characteristics of Triatomine infestation and natural Trypanosoma cruzi infection in the State of Rio Grande do Norte, Brazil

Author

Barbosa-Silva, Andressa Noronha, primary, Câmara, Antonia Cláudia Jácome da, additional, Martins, Kiev, additional, Nunes, Daniela Ferreira, additional, Oliveira, Pedro Igor Câmara de, additional, Azevedo, Paulo Roberto Medeiros de, additional, Chiari, Egler, additional, and Galvão, Lúcia Maria da Cunha, additional

Published
2016
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33. Dados clínicos, laboratoriais e epidemiológicos de pacientes chagásicos residentes no noroeste do Paraná, Brazil

Author

Gomes, Mônica Lúcia, Cassarotti, Dirceu José, Ramos, Miria, Zanzarini, Paulo Donizete, Galvão, Lúcia Maria Cunha, Chiari, Egler, and Marques-Araújo, Silvana

Subjects
PCR, 2.00.00.00-6 Ciências Biológicas, hemocultura, dados epidemiológicos, doença de Chagas, anticorpos líticos, noroeste do Paraná
Abstract

Clinical, laboratory and epidemiological data of 48 chagasic patients living in the northwestern region of the State of Paraná were analyzed. The clinical study revealed abnormalities in 59.5% of electrocardiograms and 27% of chest x-rays. Prior to etiologic treatment, all patients had positive IIF and ELISA, except for one case with a IIF titer of 20. Hemoculture, CoML and PCR were positive in 41.7%, 89.6% and 83.3% of subjects respectively. The subjects included women (52.1%) and men (47.9%) with average age of 46.9 ± 10.1 years mainly from the States of Minas Gerais and São Paulo (70.9%) and Paraná (18.8%). The majority acquired the infection through vector contact (95.8%) and 79.2% discovered the disease because they felt ill and looked for medical care, while 8.3% discovered their illness through blood donation. Understanding the clinical, laboratory and epidemiological data of chagasic patients is of considerable importance in order to formulate etiologic treatment proposals for these patients. The majority of the subjects in this study are in the productive phase of their lives and do not present clinical abnormalities, thus raising questions related to treatment which will be evaluated in future studies. Neste trabalho, foram avaliados os dados clínicos, laboratoriais e epidemiológicos de 48 pacientes chagásicos residentes na região noroeste do Paraná. No estudo clínico, o eletrocardiograma e o raio-X de tórax estavam alterados em 59,5% e 27% dos pacientes, respectivamente. Dos testes laboratoriais realizados antes de se propor o tratamento etiológico, a IFI e ELISA apresentaram resultados positivos em todos os pacientes, exceto um caso com título da IFI 20. A hemocultura, LMCo e PCR foram positivas em 41,7%, 89,6% e 83,3%, respectivamente. Observamos que 52,1% da população era feminina e 47,1% masculina com idade média de 46,9 ± 10,1 anos. Quanto à procedência, 70,9% eram procedentes de Minas Gerais e São Paulo e 18,8% relataram ser paranaenses. A grande maioria (95,8%) adquiriu a infecção por via vetorial, 79,2% descobriu a doença de Chagas ao procurar o médico e 8,3% quando foi doar sangue. O estudo dos dados clínicos, laboratoriais e epidemiológicos de pacientes chagásicos torna-se hoje de maior interesse porque, diante desse quadro devemos propor o tratamento etiológico desses pacientes. A grande maioria dos pacientes desse estudo está na fase produtiva de suas vidas e não apresenta alterações clínicas, fatos que levaram a proposição do tratamento etiológico desses pacientes, etapa esta que será avaliada em trabalhos futuros.

Published
2008

35. First evidence of Trypanosoma rangeli in the southeast of Brazil, an endemic region to Chagas' disease

Author

Ramirez,Luis Eduardo, Machado,Maria Inês, Maywald,Paula G., Matos,Aldo, Chiari,Egler, and Silva,Eliane Lages

Subjects
Chagas' disease, Tripanosoma rangeli, Trypanosoma rangeli, Didelphis albiventris, Doença de Chagas
Abstract

Informa-se, pela primeira vez, os achados de Trypanosoma rangeli no Triângulo Mineiro, Sudeste do Brasil, área altamente endêmica para doença de Chagas, assim como a infecção natural da espécie Didelphis albiventris.com este mesmo tripanosoma. Estes foram demonstrados por esfregaços sangüíneos, xenodiagnóstico, hemocultura, microhematócrito e PCR. A PCR foi realizada nas fezes e hemolinfa de Triatoma infestans, usando como controle cepas de T. rangeli provenientes da Colômbia. This short communication informs the discovery of Trypanosoma rangeli for the first time at Triângulo Mineiro region, South-east of Brazil, a highly endemic area of Chagas'disease and also the natural infection of Didelphis albiventris with the same trypanosome. Both the findings were demonstrated through blood smears, xenodiagnosis, microhematocrit technics and PCR. The last one was realized in faeces and hemolymph of Triatoma infestans utilizing as controls strains of T. rangeli from Colombia.

Published
1998

36. Unequivocal Identification of Subpopulations in Putative Multiclonal Trypanosoma cruzi Strains by FACs Single Cell Sorting and Genotyping

Author

Valadares, Helder Magno Silva, primary, Pimenta, Juliana Ramos, additional, Segatto, Marcela, additional, Veloso, Vanja Maria, additional, Gomes, Mônica Lúcia, additional, Chiari, Egler, additional, Gollob, Kenneth John, additional, Bahia, Maria Terezinha, additional, de Lana, Marta, additional, Franco, Glória Regina, additional, Machado, Carlos Renato, additional, Pena, Sérgio Danilo Junho, additional, and Macedo, Andréa Mara, additional

Published
2012
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37. Hematological alterations during experimental canine infection by Trypanosoma cruzi

Author

Guedes, Paulo Marcos Matta, primary, Veloso, Vanja Maria, additional, Mineo, Tiago Wilson Patriarca, additional, Santiago-Silva, Juliana, additional, Crepalde, Geovan, additional, Caldas, Ivo Santana, additional, Nascimento, Manuela Sales Lima, additional, Lana, Marta, additional, Chiari, Egler, additional, Galvão, Lúcia Maria da Cunha, additional, and Bahia, Maria Terezinha, additional

Published
2012
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39. Membrane Cholesterol Regulates Lysosome-Plasma Membrane Fusion Events and Modulates Trypanosoma cruzi Invasion of Host Cells

Author

Hissa, Bárbara, primary, Duarte, Jacqueline G., additional, Kelles, Ludmila F., additional, Santos, Fabio P., additional, del Puerto, Helen L., additional, Gazzinelli-Guimarães, Pedro H., additional, de Paula, Ana M., additional, Agero, Ubirajara, additional, Mesquita, Oscar N., additional, Guatimosim, Cristina, additional, Chiari, Egler, additional, and Andrade, Luciana O., additional

Published
2012
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40. Coinfection with Different Trypanosoma cruzi Strains Interferes with the Host Immune Response to Infection

Author

Rodrigues, Claudiney Melquíades, primary, Valadares, Helder Magno Silva, additional, Francisco, Amanda Fortes, additional, Arantes, Jerusa Marilda, additional, Campos, Camila França, additional, Teixeira-Carvalho, Andréa, additional, Martins-Filho, Olindo Assis, additional, Araujo, Márcio Sobreira Silva, additional, Arantes, Rosa Maria Esteves, additional, Chiari, Egler, additional, Franco, Glória Regina, additional, Machado, Carlos Renato, additional, Pena, Sérgio Danilo Junho, additional, Faria, Ana Maria Caetano, additional, and Macedo, Andréa Mara, additional

Published
2010
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42. The MHC Gene Region of Murine Hosts Influences the Differential Tissue Tropism of Infecting Trypanosoma cruzi Strains

Author

Freitas, Jorge M., primary, Andrade, Luciana O., additional, Pires, Simone F., additional, Lima, Ricardo, additional, Chiari, Egler, additional, Santos, Ricardo R., additional, Soares, Milena, additional, Machado, Carlos R., additional, Franco, Gloria R., additional, Pena, Sergio D. J., additional, and Macedo, Andrea M., additional

Published
2009
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44. Ancestral Genomes, Sex, and the Population Structure of Trypanosoma cruzi

Author

de Freitas, Jorge M., primary, Augusto-Pinto, Luiz, additional, Pimenta, Juliana R, additional, Bastos-Rodrigues, Luciana, additional, Gonçalves, Vanessa F, additional, Teixeira, Santuza M. R, additional, Chiari, Egler, additional, Junqueira, Ângela C. V, additional, Fernandes, Octavio, additional, Macedo, Andréa M, additional, Machado, Carlos Renato, additional, and Pena, Sérgio D. J, additional

Published
2006
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