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1. Extended-Duration Betrixaban Reduces the Risk of Stroke Versus Standard-Dose Enoxaparin Among Hospitalized Medically Ill Patients

Author

Legkonogov, O., Ramacciotti, E., Mikhailova, E., Koryk, V., Adzerikho, I., Schoenerr, H., Mathies, R., Konig, J., Huber, K., Rubinfeld, A., Finfer, S., Manenti, E., Bott, M., Blessing, E., Beyer-Westendorf, J., Coughlin, P., Baker, R., Poy, C., Dengler, T., Parody, M., Oliva, M., Macin, S., Jure, H., Ferrari, A. E., Dziewas, R., Genth-Zotz, S., Hamann, F., Horacek, T., Klimpe, S., Mitkovskaya, N., Kroning, R., Lapp, H., Lawall, H., Licka, M., Rizos, T., Tiefenbacher, C., Weimar, C., Alkonyi, B., Falukozy, J., Futo, L., Katona, A., Berrouschot, J., Kirschner, R., Amann, B., Paposhvili, K., Pagava, Z., Kristof, P., Lakatos, F., Laszlo, Z., Freire, A., Lupkovics, G., Megreladze, I., Kobulia, B., Khintibidze, I., Khabeishvili, G., Datikashvili-David, I., Simoneau, G., Merkely, B., Andras, C. Nagy, Nemeth, L., Papp, A., Soltesz, P., Fiss, E., Schmidt, J., Roy, P-M., Quere, I., Proust, A., Pottier, P., Pernod, G., Payot, L., Bizzacchi, J. Annichino, Lienart, F., Paleiron, N., Montaclair, K., Mismetti, P., Messas, E., Lacroix, P., Grange, C., Falvo, N., El Kouri, D., Decoulx, E., Debourdeau, P., De Geeter, G., Brisot, D., Belhassane, A., Aquilanti, S., Agraou, B., Vikman, S., Tatlisumak, T., Saarinen, J., Kaaja, R., Honkaniemi, J., Airaksinen, J., Uuetoa, T., Lember, M., Urhammer, S., Tuxen, C., Storgaard, M., Lassen, M., Christensen, H., Vyhnanek, M., Vejvoda, J., Spacek, R., Reiterer, P., Podpera, I., Mikulova, J., Lang, P., Jajtner, P., Hubac, J., Horny, I., Holaj, R., Herold, M., Havelka, J., Francek, L., Dusek, J., Dunaj, M., Cizek, V., Chochola, J., Chlumsky, J., Cermak, O., Skerk, V., Vagic, J. Sikic, Marusic, S., Knezevic, A., Kalinic-Grgorinic, H., Jakopovic, M., Francetic, I., Ciglenecki, N., Car, S., Butkovic-Soldo, S., Cardenas, S. Potthoff, Lazcano, M. Opazo, Alarcon, M. Arias, Verreault, S., Provencher, S., Pearce, M., Le Gal, G., Douketis, J., Dhar, A., Tokmakova, M., Todorov, G., Syulemzova, S., Raymuno, S., Rocha, A., Dimov, B., Grigorov, M., Kalpachki, R., Kamenova, Z., Bello, F., Harrington, Robert A., Bandman, Olga, Kostadinova, M., Milanova, M., Dive, A., Pencheva, G., Sudar, Z., Szabo, G., Szegedi, N., Timar, G., Valco, J., Delforge, M., Vertes, A., Efrati, S., Elias, M., Gafter, A., Nazliel, BİJEN, Hayek, T., Hussein, O., Lishner, M., Lugassy, G., Cerveri, I., D'Angelo, A., De Pellegrin, A., Imberti, D., Landolfi, R., Runev, N., Lembo, G., Lodigiani, C., Moia, M., Molteni, M., Mumoli, N., Novo, S., Orlandini, F., Stoeva, N., Parisi, R., Pizzini, A., Pomero, F., Salvi, A., Schenone, A., Gold, Alex, Visona, A., Martinova, V., Pontaga, N., Rozitis, V., Stukena, I., Alekniene, B., Basijokiene, V., Butkiene, Z., Griskeviciene, V., Naudziunas, A., Stoyanov, M., Norvaisiene, R., Norviliene, R., Petrauskiene, R., Poskiene, R., Susinskiene, D., Valavicius, A., Castillo Leon, R., Pimanov, S., Polonetsy, L., Pereyra, R. Cotrina, Karlo, L. Farjardo, Horna, M., Soroka, N., Salas, M., Yanez, L. Toche, Fryze, W., Gaciong, Z., Gniot, J., Gorecka, D., Gruenpeter, P., Grzelakowski, P., Jastrzebski, D., Kucharski, L., Mirek-Bryniarska, E., Pulkowski, G., Sobkowicz, B., Sulik, P., Walasek, L., Blockmans, D., Waldemar, K., Wrzesinski, K., Balogh, Z. E., Bojinca, M., Marin, I., Musetescu, R., Podoleanu, C., Popescu, M., Stamate, S., Stanciulescu, G., Vida-Simiti, L., Abashev, A., Andreev, D., Apartsin, K., Arkhipov, M., Averkov, O., Barbarash, O., Belskaya, G., Bogdanov, E., Boldueva, S., Chefranova, Z., Dovgalevskiy, Y., Ershova, O., Goloshchekin, B., Khachatryan, N., Klein, G., Kobalava, Z., Kosmacheva, E., Kostenko, V., Malygin, A., Martynenko, T., Martynenko, V., Maslova, N., Mordovin, V., Nikolaev, K., Nilk, R., Popov, D., Privalova, E., Reshetko, O., Shapovalova, Y., Shpagina, L., Shvarts, Y., Simanenkov, V., Solovyov, O., Vishneva, E., Vishnevskiy, A., Apostolovic, S., Celic, V., Ilic, S., Kovacevic-Kuzmanovic, A., Miloradovic, V., Bodikova, S., Cervenakova, A., Dvorak, M., Herman, O., Hrubon, A., Kokles, M., Krastev, G., Payer, J., Prokop, D., Spisakova, M., Adler, D., Basson, M., Breedt, J., Engelbrecht, J., Mitha, I., Van Dyk, C., Alvarez Sala, L. A., Barbagelata Lopez, C., Bisbe, J., Castro Guardiola, A., Cepeda, J. M., Cereto, F., Diaz Santos, E., Ferrer, R., Gomez Cerezo, J., Hernandez, Adrian F., Gonzales-Porras, J. R., Grandes, J., Cohen, Alexander T., Gibson, C. Michael, Chi, Gerald, Halaby, Rim, Korjian, Serge, Daaboul, Yazan, Jain, Purva, Arbetter, Douglas, Goldhaber, Samuel Z., Hull, Russel, Jimenez, D., Mellibovsky, L., Richart, C., Riera, A., Trujillo, J., Vargas Nunez, J. A., Villalta, J., Akgul, O., Guneri, S., Kilichesmez, K., Kirma, C., Kutluk, H., Okumus, G., Tigen, K., Topcuoglu, M., Tuncay, E., Abrahamovych, O., Batushkin, V., Brozhyk, J., Burmak, I., Godlevska, O., Goloborodko, A., Goloborodko, B., Goncharova, Y., Gryb, V., Karpenko, O., Kopytsya, M., Zakai, N., Yousef, K., Wichman, T., Whitman, B., Welker, J., Welch, M., Warner, A., Updegrove, J., Tuck, M., Stoltz, S., Sokol, S., Sharma, S., Shammas, N., Saba, F., Rodriguez, W., Rees, C., Rastogi, P., Rajan, R., Quintana, O., Pullman, J., Pratt, R., Pineda, L., Pearl, R., Parthiban, K., Overcash, J., Ortel, T., Ohaju, V., Nadar, V., Mittal, M., Milling, T., McLaren, G., Margolis, B., Mahal, S., Macchiavelli, A., Lopez, J., Lerner, R., Kung, M., Kouras, F., Kazimir, M., Kao, C-K., Kabler, H., Ioachimescu, O., Hazelrigg, M., Hamad, A., Haidar, A., Hahn, B., Goytia-Leos, D., Gaggin, H., Fulmer, J., Koshlia, V., Fraiz, J., Krakhmalova, O., Fermann, G., Farley, B., Doshi, A., Dhingra, R., Cornell, J., Concha, M., Clark, C., Chang, H., Carman, T., Bidair, M., Bercz, P., Bastani, A., Barney, J., Baker, S., Anderson, C., Amin, M., Almasri, E., Natarajan, I., McCollum, C., MacCallum, P., Davis, M., Body, R., Yagensky, A., Voronkov, L., Vishnivestsky, I., Vakaliuk, I., Ursol, G., Tseluyko, V., Kyrychenko, I., Svyshchenko, Y., Svyridova, I., Ryabichenko, T., Rudenko, L., Reshotko, D., Perepeliuk, M., Parkhomenko, O., Nikonov, V., Maslovaskyi, V., Malynovsky, Y., Sergeeva, E., and Kolman, P. more...

Subjects
Male, medicine.medical_specialty, Pyridines, Intracranial Hemorrhages, 030204 cardiovascular system & hematology, 03 medical and health sciences, chemistry.chemical_compound, 0302 clinical medicine, Medical illness, Physiology (medical), medicine, Humans, 030212 general & internal medicine, Enoxaparin, Intensive care medicine, Stroke, Aged, business.industry, Anticoagulants, Venous Thromboembolism, medicine.disease, Thrombosis, chemistry, Betrixaban, Benzamides, Emergency medicine, Female, Cardiology and Cardiovascular Medicine, business, Complication, Venous thromboembolism
Abstract

Background: Stroke is a morbid and potentially mortal complication among patients hospitalized with acute medical illness. The potential of extended-duration thromboprophylaxis with the factor Xa inhibitor betrixaban to reduce the risk of stroke compared with standard-dose enoxaparin in this population was assessed in this retrospective APEX trial substudy (Acute Medically Ill Venous Thromboembolism Prevention With Extended Duration Betrixaban). Methods: Hospitalized acutely medically ill subjects (n=7513) were randomized in a double-dummy double-blind fashion to either extended-duration oral betrixaban (80 mg once daily for 35–42 days) or standard-dose subcutaneous enoxaparin (40 mg once daily for 10±4 days) for venous thromboprophylaxis. Stroke events were adjudicated by an independent, blinded event adjudication committee. Results: The mean age of study participants was 76 years; 45% were male; 13% had had a stroke; and 45% had congestive heart failure. There were fewer all-cause strokes (0.54% versus 0.97%; relative risk [RR]=0.56; 95% confidence interval, 0.32–0.96; P =0.032; adjusted RR=0.43%; number needed to treat=233) and ischemic strokes (0.48% versus 0.91%; RR=0.53; 95% confidence interval, 0.30–0.94; P =0.026; adjusted RR=0.43%; number needed to treat=233) among patients treated with betrixaban versus enoxaparin through 77 days of follow-up. Among high-risk subjects, those with congestive heart failure or ischemic stroke as their index event, betrixaban reduced the risk of all-cause stroke (0.72% versus 1.48%; RR=0.49; 95% confidence interval, 0.26–0.90; P =0.019; adjusted RR=0.76%; number needed to treat=132) and ischemic stroke (0.63% versus 1.38%; RR=0.45; 95% confidence interval, 0.24–0.87; P =0.014; adjusted RR=0.75%; number needed to treat=134) compared with enoxaparin. Conclusions: Among hospitalized medically ill patients, extended-duration betrixaban significantly reduced all-cause stroke and ischemic stroke through 77 days of follow-up Clinical Trial Registration: URL: http://www.clinicaltrials.gov . Unique identifier: NCT01583218. more...

Published
2017
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2. Management and 1‐Year Outcomes of Patients With Newly Diagnosed Atrial Fibrillation and Chronic Kidney Disease: Results From the Prospective GARFIELD‐AF Registry

Author

Goto, Shinya, primary, Angchaisuksiri, Pantep, additional, Bassand, Jean‐Pierre, additional, Camm, A. John, additional, Dominguez, Helena, additional, Illingworth, Laura, additional, Gibbs, Harry, additional, Goldhaber, Samuel Z., additional, Goto, Shinichi, additional, Jing, Zhi‐Cheng, additional, Haas, Sylvia, additional, Kayani, Gloria, additional, Koretsune, Yukihiro, additional, Lim, Toon Wei, additional, Oh, Seil, additional, Sawhney, Jitendra P. S., additional, Turpie, Alexander G. G., additional, van Eickels, Martin, additional, Verheugt, Freek W. A., additional, Kakkar, Ajay K., additional, Fitzmaurice, David A., additional, Hacke, Werner, additional, Mantovani, Lorenzo G., additional, Misselwitz, Frank, additional, Pieper, Karen S., additional, Fox, Keith A. A., additional, Gersh, Bernard J., additional, Luciardi, Hector Lucas, additional, Brodmann, Marianne, additional, Cools, Frank, additional, Barretto, Antonio Carlos Pereira, additional, Connolly, Stuart J., additional, Spyropoulos, lex, additional, Eikelboom, John, additional, Corbalan, Ramon, additional, Hu, Dayi, additional, Jansky, Petr, additional, Nielsen, Jørn Dalsgaard, additional, Ragy, Hany, additional, Raatikainen, Pekka, additional, Le Heuzey, Jean‐Yves, additional, Darius, Harald, additional, Keltai, Matyas, additional, Kakkar, Sanjay, additional, Agnelli, Giancarlo, additional, Ambrosio, Giuseppe, additional, Sánchez Díaz, Carlos Jerjes, additional, Ten Cate, Hugo, additional, Atar, Dan, additional, Stepinska, Janina, additional, Panchenko, Elizaveta, additional, Jacobson, Barry, additional, Viñolas, Xavier, additional, Rosenqvist, Marten, additional, Steffel, Jan, additional, Oto, Ali, additional, Parkhomenko, Alex, additional, Mahmeed, Wael Al, additional, Fitzmaurice, David, additional, Chen, K. N., additional, Zhao, Y. S., additional, Zhang, H. Q., additional, Chen, J. Z., additional, Cao, S. P., additional, Wang, D. W., additional, Yang, Y. J., additional, Li, W. H., additional, Yin, Y. H., additional, Tao, G. Z., additional, Yang, P., additional, Chen, Y. M., additional, He, S. H., additional, Wang, Y. (Ying), additional, Wang, Y. (Yong), additional, Fu, G. S., additional, Li, X., additional, Wu, T. G., additional, Cheng, X. S., additional, Yan, X. W., additional, Zhao, R. P., additional, Chen, M. S., additional, Xiong, L. G., additional, Chen, P., additional, Jiao, Y., additional, Guo, Y., additional, Xue, L., additional, Wang, F. Z., additional, Li, H., additional, Yang, Z. M., additional, Bai, C. L., additional, Chen, J., additional, Chen, J. Y., additional, Chen, X., additional, Feng, S., additional, Fu, Q. H., additional, Gao, X. J., additional, Guo, W. N., additional, He, R. H., additional, He, X. A., additional, Hu, X. S., additional, Huang, X. F., additional, Li, B., additional, Li, J., additional, Li, L., additional, Li, Y. H., additional, Liu, T. T., additional, Liu, W. L., additional, Liu, Y. Y., additional, Lu, Z. C., additional, Luo, X. L., additional, Ma, T. Y., additional, Peng, J. Q., additional, Sheng, X., additional, Shi, X. J., additional, Sun, Y. H., additional, Tian, G., additional, Wang, K., additional, Wang, L., additional, Wu, R. N., additional, Xie, Q., additional, Xu, R. Y., additional, Yang, J. S., additional, Yang, L. L., additional, Yang, Q., additional, Ye, Y., additional, Yu, H. Y., additional, Yu, J. H., additional, Yu, T., additional, Zhai, H., additional, Zhan, Q., additional, Zhang, G. S., additional, Zhang, Q., additional, Zhang, R., additional, Zhang, Y., additional, Zheng, W. Y., additional, Zhou, B., additional, Zhou, Z. H., additional, Zhu, X. Y., additional, Oda, H. (Hiroshi), additional, Nakamura, (Tadashi), additional, Nakamura, T. (Tsugihiro), additional, Fujiura, Y. (Yoshihisa), additional, Saito, K. (Katsumi), additional, Saito, K. (Kazuyuki), additional, Fujiura, Y. (Yoshitake), additional, Nakamura, Y. (Yoichi), additional, Oda, H. (Hiroyuki), additional, Morii, S., additional, Shiga, Y. (Yuhei), additional, Nii, K., additional, Nakamura, Y. (Yuichiro), additional, Fujii, M., additional, Abe, M. (Masahiko), additional, Abe, M. (Masatake), additional, Abe, M. (Mitsunori), additional, Saito, T., additional, Mito, T., additional, Nagao, K., additional, Minami, J., additional, Mita, T., additional, Sakuma, I., additional, Taguchi, T., additional, Marusaki, S., additional, Doi, H., additional, Tanaka, M., additional, Fujito, T., additional, Matsuta, M., additional, Kusumoto, T., additional, Kakinoki, S., additional, Ashida, K., additional, Yoshizawa, N., additional, Agata, J., additional, Arasaki, O., additional, Manita, M., additional, Ikemura, M., additional, Fukuoka, S., additional, Murakami, H., additional, Matsukawa, S., additional, Hata, Y., additional, Taniguchi, T., additional, Ko, T., additional, Kubo, H., additional, Imamaki, M., additional, Akiyama, M., additional, Inagaki, M., additional, Odakura, H., additional, Ueda, T., additional, Katsube, Y., additional, Nakata, A., additional, Watanabe, H., additional, Techigawara, M., additional, Igarashi, M., additional, Taga, K., additional, Kimura, T., additional, Tomimoto, S., additional, Shibuya, M., additional, Nakano, M., additional, Ito, K., additional, Seo, T., additional, Hiramitsu, S., additional, Hosokawa, H., additional, Hoshiai, M., additional, Hibino, M., additional, Miyagawa, K., additional, Horie, H. (Hajime), additional, Sugishita, N., additional, Shiga, Y. (Yukio), additional, Soma, A., additional, Neya, K., additional, Yoshida, T. (Tetsuro), additional, Yoshida, T. (Tomoki), additional, Mizuguchi, M., additional, Ishiguro, M., additional, Minagawa, T., additional, Wada, M., additional, Mukawa, H., additional, Okuda, F., additional, Nagasaka, S., additional, Abe, Y., additional, Adachi, S. (Sen), additional, Adachi, S. (Susumu), additional, Adachi, T., additional, Akahane, K., additional, Amano, T., additional, Aoki, K., additional, Aoyama, T., additional, Arai, H., additional, Arima, S., additional, Arino, T., additional, Asano, H., additional, Asano, T., additional, Azuma, J., additional, Baba, T., additional, Betsuyaku, T., additional, Chibana, H., additional, Date, H., additional, Doiuchi, J., additional, Emura, Y., additional, Endo, M., additional, Fujii, Y., additional, Fujiki, R., additional, Fujisawa, A., additional, Fujisawa, Y., additional, Fukuda, T., additional, Fukui, T., additional, Furukawa, N., additional, Furukawa, T., additional, Furumoto, W., additional, Goto, T., additional, Hamaoka, M., additional, Hanazono, N., additional, Hasegawa, K., additional, Hatsuno, T., additional, Hayashi, Y., additional, Higuchi, K., additional, Hirasawa, K., additional, Hirayama, H., additional, Hirose, M., additional, Hirota, S., additional, Honda, M., additional, Horie, H. (Hideki), additional, Ido, T., additional, Iiji, O., additional, Ikeda, H., additional, Ikeda, K., additional, Ikeoka, K., additional, Imaizumi, M., additional, Inaba, H., additional, Inoue, T., additional, Iseki, F., additional, Ishihara, A., additional, Ishioka, N., additional, Ito, N., additional, Iwase, T., additional, Kakuda, H., additional, Kamata, J., additional, Kanai, H., additional, Kanda, H., additional, Kaneko, M., additional, Kano, H., additional, Kasai, T., additional, Kato, T., additional, Kato, Y., additional, Kawada, Y., additional, Kawai, K., additional, Kawakami, K., additional, Kawakami, S., additional, Kawamoto, T., additional, Kawano, S., additional, Kim, J., additional, Kira, T., additional, Kitazawa, H., additional, Kitazumi, H., additional, Kito, T., additional, Kobayashi, T., additional, Koeda, T., additional, Kojima, J., additional, Komatsu, H., additional, Komatsu, I., additional, Koshibu, Y., additional, Kotani, T., additional, Kozuka, T., additional, Kumai, Y., additional, Kumazaki, T., additional, Maeda, I., additional, Maeda, K., additional, Maruyama, Y., additional, Matsui, S., additional, Matsushita, K., additional, Matsuura, Y., additional, Mineoi, K., additional, Mitsuhashi, H., additional, Miura, N., additional, Miyaguchi, S., additional, Miyajima, S., additional, Miyamoto, H., additional, Miyashita, A., additional, Miyata, S., additional, Mizuguchi, I., additional, Mizuno, A., additional, Mori, T., additional, Moriai, O., additional, Morishita, K., additional, Murai, O., additional, Nagai, S. (Sho), additional, Nagai, S. (Shunichi), additional, Nagata, E., additional, Nagata, H., additional, Nakagomi, A., additional, Nakahara, S., additional, Nakamura, M., additional, Nakamura, R., additional, Nakanishi, N., additional, Nakayama, T., additional, Nakazato, R., additional, Nanke, T., additional, Nariyama, J., additional, Niijima, Y., additional, Niinuma, H., additional, Nishida, Y., additional, Nishihata, Y., additional, Nishino, K., additional, Nishioka, H., additional, Nishizawa, K., additional, Niwa, I., additional, Nomura, K., additional, Nomura, S., additional, Nozoe, M., additional, Ogawa, T., additional, Ohara, N., additional, Okada, M., additional, Okamoto, K., additional, Okita, H., additional, Okuyama, M., additional, Ono, H., additional, Ono, T., additional, Onuki Pearce, Y., additional, Oriso, S., additional, Ota, A., additional, Otaki, E., additional, Saito, Y., additional, Sakai, H., additional, Sakamoto, N., additional, Sakamoto, Y., additional, Samejima, Y., additional, Sasagawa, Y., additional, Sasaguri, H., additional, Sasaki, A., additional, Sasaki, T., additional, Sato, K. (Kazuki), additional, Sato, K. (Kiyoharu), additional, Sawano, M., additional, Seki, S., additional, Sekine, Y., additional, Seta, Y., additional, Sezaki, K., additional, Shibata, N., additional, Shiina, Y., additional, Shimono, H., additional, Shimoyama, Y., additional, Shindo, T., additional, Shinohara, H., additional, Shinohe, R., additional, Shinozuka, T., additional, Shirai, T., additional, Shiraiwa, T., additional, Shozawa, Y., additional, Suga, T., additional, Sugimoto, C., additional, Suzuki, K. (Kazuo), additional, Suzuki, K. (Keita), additional, Suzuki, S. (Shu), additional, Suzuki, S. (Shunji), additional, Suzuki, S. (Susumu), additional, Suzuki, Y., additional, Tada, M., additional, Taguchi, A., additional, Takagi, T., additional, Takagi, Y., additional, Takahashi, K., additional, Takahashi, S., additional, Takai, H., additional, Takanaka, C., additional, Take, S., additional, Takeda, H., additional, Takei, K., additional, Takenaka, K., additional, Tana, T., additional, Tanabe, G., additional, Taya, K., additional, Teragawa, H., additional, Tohyo, S., additional, Toru, S., additional, Tsuchiya, Y., additional, Tsuji, T., additional, Tsuzaki, K., additional, Uchiyama, H., additional, Ueda, O., additional, Ueyama, Y., additional, Wakaki, N., additional, Wakiyama, T., additional, Washizuka, T., additional, Watanabe, M., additional, Yamada, T., additional, Yamagishi, T., additional, Yamaguchi, H., additional, Yamamoto, K. (Kenichi), additional, Yamamoto, K. (Kentaro), additional, Yamamoto, K. (Kunihiko), additional, Yamamoto, T., additional, Yamaura, M., additional, Yamazoe, M., additional, Yasui, K., additional, Yokoyama, Y., additional, Yoshida, K., additional, Ching, C. K., additional, Foo, C. G., additional, Chow, J. H., additional, Chen, D. D., additional, Jaufeerally, F. R., additional, Lee, Y. M., additional, Lim, G., additional, Lim, W. T., additional, Thng, S., additional, Yap, S. Y., additional, Yeo, C., additional, Pak, H. N., additional, Kim, J.‐B., additional, Kim, J. H., additional, Jang, S.‐W., additional, Kim, D. H., additional, Ryu, D. R., additional, Park, S. W., additional, Kim, D.‐K., additional, Choi, D. J., additional, Oh, Y. S., additional, Cho, M.‐C., additional, Kim, S.‐H., additional, Jeon, H.‐K., additional, Shin, D.‐G., additional, Park, J. S., additional, Park, H. K., additional, Han, S.‐J., additional, Sung, J. H., additional, Cho, J.‐G., additional, Nam, G.‐B., additional, On, Y. K., additional, Lim, H. E., additional, Kwak, J. J., additional, Cha, T.‐J., additional, Hong, T. J., additional, Park, S. H., additional, Yoon, J. H., additional, Kim, N.‐H., additional, Kim, K.‐S., additional, Jung, B. C., additional, Hwang, G.‐S., additional, Kim, C.‐J., additional, Kim, D. B., additional, Ahn, J. J., additional, An, H. J., additional, Bae, H., additional, Baek, A. L., additional, Chi, W. J., additional, Choi, E. A., additional, Choi, E. H., additional, Choi, H. K., additional, Choi, H. S., additional, Han, S., additional, Heo, E. S., additional, Her, K. O., additional, Hwang, S. W., additional, Jang, E. M., additional, Jang, H.‐S., additional, Jang, S., additional, Jeon, H.‐G., additional, Jeon, S. R., additional, Jeon, Y. R., additional, Jeong, H. K., additional, Jung, I.‐A., additional, Kim, H. J. (Hyeon Jeong), additional, Kim, H. J. (Hyun Ju), additional, Kim, J. S. (Ji Seon), additional, Kim, J. S. (Jung Sook), additional, Kim, J. A., additional, Kim, K. T., additional, Kim, M. S., additional, Kim, S. H. (Sang Hee), additional, Kim, S. H. (Sang Hyun), additional, Kim, Y.‐I., additional, Lee, C. S., additional, Lee, E. H., additional, Lee, G. H., additional, Lee, H. Y., additional, Lee, H.‐Y., additional, Lee, K. H., additional, Lee, K. R., additional, Lee, M. S., additional, Lee, M.‐Y., additional, Lee, R. W., additional, Lee, S. E., additional, Lee, S. H., additional, Lee, S., additional, Lee, W. Y., additional, Noh, I. K., additional, Park, A. R., additional, Park, B. R., additional, Park, H. N., additional, Park, J. H., additional, Park, M., additional, Park, Y., additional, Seo, S.‐Y., additional, Shim, J., additional, Sim, J. H., additional, Sohn, Y. M., additional, Son, W. S., additional, Son, Y. S., additional, Song, H. J., additional, Wi, H. K., additional, Woo, J. J., additional, Ye, S., additional, Yim, K. H., additional, Yoo, K. M., additional, Yoon, E. J., additional, Yun, S. Y., additional, Chawanadelert, S., additional, Mongkolwongroj, P., additional, Kanokphatcharakun, K., additional, Cheewatanakornkul, S., additional, Laksomya, T., additional, Pattanaprichakul, S., additional, Chantrarat, T., additional, Rungaramsin, S., additional, Silaruks, S., additional, Wongcharoen, W., additional, Siriwattana, K., additional, Likittanasombat, K., additional, Katekangplu, P., additional, Boonyapisit, W., additional, Cholsaringkarl, D., additional, Chatlaong, B., additional, Chattranukulchai, P., additional, Santanakorn, Y., additional, Hutayanon, P., additional, Khunrong, P., additional, Bunyapipat, T., additional, Jai‐Aue, S., additional, Kaewsuwanna, P., additional, Bamungpong, P., additional, Gunaparn, S., additional, Hongsuppinyo, S., additional, Inphontan, R., additional, Khattaroek, R., additional, Khunkong, K., additional, Kitmapawanont, U., additional, Kongsin, C., additional, Naratreekoon, B., additional, Ninwaranon, S., additional, Phangyota, J., additional, Phrommintikul, A., additional, Phunpinyosak, P., additional, Pongmorakot, K., additional, Poomiphol, S., additional, Pornnimitthum, N., additional, Pumprueg, S., additional, Ratchasikaew, S., additional, Sanit, K., additional, Sawanyawisuth, K., additional, Silaruks, B., additional, Sirichai, R., additional, Sriwichian, A., additional, Suebjaksing, W., additional, Sukklad, P., additional, Suttana, T., additional, Tangsirira, A., additional, Thangpet, O., additional, Tiyanon, W., additional, Vorasettakarnkij, Y., additional, Wisaratapong, T., additional, Wongtheptien, W., additional, Wutthimanop, A., additional, Yawila, S., additional, Altun, A., additional, Ozdogru, I., additional, Ozdemir, K., additional, Yilmaz, O., additional, Aydinlar, A., additional, Yilmaz, M. B., additional, Yeter, E., additional, Ongen, Z., additional, Cayli, M., additional, Pekdemir, H., additional, Ozdemir, M., additional, Sucu, M., additional, Sayin, T., additional, Demir, M., additional, Yorgun, H., additional, Ersanli, M., additional, Okuyan, E., additional, Aras, D., additional, Abdelrahman, H., additional, Aktas, O., additional, Alpay, D., additional, Aras, F., additional, Bireciklioglu, M. F., additional, Budeyri, S., additional, Buyukpapuc, M., additional, Caliskan, S., additional, Esen, M., additional, Felekoglu, M. A., additional, Genc, D., additional, Ikitimur, B., additional, Karaayvaz, E. B., additional, Kılıç Karataş, S., additional, Okutucu, S., additional, Ozcelik, E., additional, Quisi, A., additional, Sag, H., additional, Sahiner, L., additional, Sayin, B. Y., additional, Seker, T., additional, Uzun Alkan, D., additional, Yildirim, E., additional, Yildirim, R., additional, Yilmaz, F., additional, Yuksekdag, V., additional, Vensentini, N., additional, Ingaramo, A. C., additional, Sambadaro, G. A., additional, Fernandez Caputi, V., additional, Berman, S. G., additional, Dragotto, P., additional, Kleiban, A. J., additional, Centurion, N., additional, Giacomi, G., additional, Ahuad Guerrero, R. A., additional, Conde, D., additional, Zapata, G., additional, Di Paola, L. A., additional, Ramos, J. L., additional, Dran, R. D., additional, Egido, J., additional, Fernandez, A. A., additional, Fosco, M. J., additional, Sassone, S., additional, Sinisi, V. A., additional, Cartasegna, L. R., additional, Berli, M. A., additional, Gomez Vilamajo, O. A., additional, Ferroni, F., additional, Alaguibe, E. D., additional, D'Amelio, A. Alvarez, additional, Arabetti, C., additional, Arias, L., additional, Belardi, J. A., additional, Bergesio, L., additional, Berli, F., additional, Berli, M., additional, Borchowiec, S., additional, Buzzetti, C., additional, Cabrini, R., additional, Campisi, V., additional, Cappi, A. L., additional, Carrizo, R., additional, Colombo Berra, F., additional, Costabel, J. P., additional, Costamagna, O. J. A., additional, Damonte, A. A., additional, De Urquiza, I. N., additional, Diez, F., additional, Edén, M. F., additional, Fanuele, M., additional, Fernandez Voena, F., additional, Foa Torres, M., additional, Funosas, C., additional, Giacomi, M. P., additional, Gimenez, C. H., additional, Gurfinkel, E. P., additional, Had, M. de L. M., additional, Hansen, V., additional, Hrabar, A. D., additional, Ingratta, M., additional, Lopez, A., additional, Maehara, G., additional, Maffei, L., additional, Martinelli, A., additional, Martinelli, C., additional, Matkovich, J., additional, Mautner, B., additional, Meirino, A., additional, Munguia, R., additional, Navarro, A., additional, Novas, V., additional, Prados, G. Perez, additional, Pontoriero, J., additional, Potito, R. N., additional, Ricotti, C., additional, Rodriguez, M. A., additional, Rolandi, F., additional, Palladino, . E. Said, additional, Salinger, M., additional, Sanziani, L. S., additional, Schygiel, P. O., additional, Sossich, A., additional, Tinto, J. F., additional, Tonelli, L., additional, Tufare, A. L., additional, Vallejo, M., additional, Yunis, M. E., additional, Zillo, M., additional, Zurbrigk, F. J., additional, Sobral Filho, D. C., additional, Jaber, J., additional, Armaganijan, D., additional, Faria Neto, J., additional, Steffens, A., additional, de Souza, W. Kunz Sebba Barroso, additional, de Souza Neto, J. D., additional, Ribeiro, J. M., additional, Silveira Teixeira, M., additional, Ferreira Rossi, P. R., additional, Pires, L., additional, Moreira, D., additional, Moura Jorge, J. C., additional, Lorga Filho, A. Menezes, additional, Bodanese, L. C., additional, Montera, M. Westerlund, additional, Del Carlo, C. H., additional, Da Rocha Rodrigues, T., additional, Alves da Costa, F. A., additional, Lopes, A., additional, Lopes, R., additional, Araújo, G. R., additional, Fernandes Manenti, E. R., additional, Kerr Saraiva, J. F., additional, Ferreira Braga, J. C., additional, Negri, A., additional, Souto, L., additional, Moncada, C., additional, Precoma, D. Bertolim, additional, Roquette, F., additional, Reis, G., additional, Ramos Filho, R. A., additional, Figueiredo, E. Lanna, additional, Botelho, R. Vieira, additional, Tavares, C. Munhoz da Fontoura, additional, Costantini Frack, C. 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Codonho, additional, Correa, C., additional, Costa, M., additional, Costantini Ortiz, C., additional, da Silva, L. S., additional, da Silva Paulitsch, F., additional, da Silveira, J. A., additional, Daros, E., additional, de Araújo, G. R., additional, Del Monaco, M. I., additional, Dias, C., additional, Dias, M. A., additional, Drummond Wainstein, A. P., additional, Pizzato, P. Ely, additional, Esteves, D. C., additional, Fabri, P., additional, Félix Lorenzato Fonseca, T., additional, Fernandes, E., additional, Fonseca, C., additional, Costantini, C. R. Frack, additional, Ferraz, R. Franchin, additional, Freire, F., additional, Gottardo, P., additional, Guanaes, D., additional, Guizzardi, S., additional, Magedanz, E. Hettwer, additional, Igansi, F., additional, Jannuzzi, F., additional, Junior, G., additional, Komar, D., additional, Lino, E. G., additional, Lopes, D., additional, da Silva Júnior, O. Lourenço, additional, Lustosa, E., additional, Macagnan, A. P., additional, Marinho, M. C., additional, Mazzoni, M., additional, Melo, G., additional, Mortari, L., additional, Mouco, O. M. C. C., additional, Nanzer Vital, C., additional, Ormundo, C., additional, Oss Emmer, S., additional, Palmegiani, E., additional, Pavani, R., additional, Pereira, L., additional, Pereira, V. L., additional, Perreira, R., additional, Poletti, S., additional, Quaia Fortunato, S. C., additional, Queirantes, C., additional, Pereira, N. Ramos, additional, Rech, R. L., additional, Ribeiro, S., additional, Rodrigues, A., additional, Roesch, H., additional, Reichert, T. Ruaro, additional, Santos, D., additional, Santos, I., additional, Santos, M., additional, Seroqui, M. V., additional, Silva, S., additional, Soares, L., additional, Spolaor, L., additional, Stoll, C., additional, Duda, N. Toazza, additional, Trama, L., additional, Unterkircher, B., additional, Valois, M. 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Ibsen I., additional, Bang‐Hansen, T., additional, Ellervik, C., additional, Eriksen, E., additional, Jensen, L., additional, Jensen, M., additional, Leth, M., additional, Nygaard, A., additional, Park, J., additional, Schou, M., additional, Therkelsen, A., additional, Tilma, J., additional, Vesterager, K., additional, Airaksinen, J., additional, Arola, O., additional, Koistinen, J., additional, Nappila, H., additional, Peltomäki, K., additional, Rasanen, V., additional, Vasankari, T., additional, Le Heuzey, J.‐Y., additional, Galinier, M., additional, Gottwalles, Y., additional, Paganelli, F., additional, Loiselet, P., additional, Muller, J.‐J., additional, Koujan, M. 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P., additional, Fedorowsky, A., additional, Casassus, F., additional, Berneau, J.‐B., additional, Chemin, F., additional, Falvo, N., additional, Perron, J.‐M., additional, Poulard, J.‐E., additional, Barreau, A., additional, Beltra, C., additional, Corrihons, E., additional, Decarsin, N., additional, Dubois, B., additional, Ducasse, E., additional, Giry, X., additional, Kemmel, A., additional, Ledure, S., additional, Lemaire, N., additional, Robin, F., additional, Rosolin, N., additional, Sanchez, D., additional, Suissa, A., additional, Königer, G., additional, Purr, J., additional, Gerbaulet, U., additional, Kellner, B.‐T., additional, Kopf, A., additional, Schäfer, T., additional, Zauzig, H., additional, Riegel, P., additional, Hohensee, H., additional, Eißfeller, E., additional, Eder, W., additional, Rehling, G., additional, Glatzel, D., additional, Zutz, S., additional, Heinz, G.‐U., additional, Menke, H., additional, Pustelnik, A., additional, Sandow, P., additional, Ludwig, N., 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Published
2019
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3. Extended Thromboprophylaxis with Betrixaban in Acutely Ill Medical Patients

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Engelbrecht, J., Finfer, S., Van Dyk, C., Cohen, Alexander, Grandes, J., Cepeda, J. M., NAZLIEL, BİJEN, Cohen, Alexander T., Efrati, S., Zakai, N., Yousef, K., Wichman, T., Whitman, B., Welker, J., Welch, M., Warner, A., Updegrove, J., Tuck, M., Stoltz, S., Sokol, S., Sharma, S., Shammas, N., Saba, F., Rodriguez, W., Rees, C., Rastogi, P., Rajan, R., Quintana, O., Pullman, J., Pratt, R., Pineda, L., Pearl, R., Parthiban, K., Overcash, J., Ortel, T., Ohaju, V., Nadar, V., Mittal, M., Milling, T., McLaren, G., Margolis, B., Mahal, S., Macchiavelli, A., Lopez, J., Lerner, R., Kung, M., Kouras, F., Kazimir, M., Kao, C-K., Kabler, H., Ioachimescu, O., Hazelrigg, M., Hamad, A., Haidar, A., Hahn, B., Goytia-Leos, D., Gaggin, H., Fulmer, J., Fraiz, J., Fermann, G., Farley, B., Doshi, A., Dhingra, R., Cornell, J., Concha, M., Clark, C., Chang, H., Carman, T., Bidair, M., Bercz, P., Bastani, A., Barney, J., Baker, S., Anderson, C., Amin, M., Almasri, E., Natarajan, I., McCollum, C., MacCallum, P., Davis, M., Body, R., Yagensky, A., Voronkov, L., Vishnivestsky, I., Vakaliuk, I., Ursol, G., Tseluyko, V., Svyshchenko, Y., Svyridova, I., Ryabichenko, T., Rudenko, L., Alekniene, B., Reshotko, D., Perepeliuk, M., Parkhomenko, O., Nikonov, V., Maslovaskyi, V., Malynovsky, Y., Legkonogov, O., Kyrychenko, I., Krakhmalova, O., Koshlia, V., Kopytsya, M., Karpenko, O., Gryb, V., Goncharova, Y., Goloborodko, B., Goloborodko, A., Godlevska, O., Burmak, I., Brozhyk, J., Batushkin, V., Abrahamovych, O., Tuncay, E., Topcuoglu, M., Tigen, K., Okumus, G., Kutluk, H., Kirma, C., Kilichesmez, K., Guneri, S., Akgul, O., Villalta, J., Vargas Nunez, J. A., Trujillo, J., Riera, A., Richart, C., Mellibovsky, L., Jimenez, D., Gonzales-Porras, J. R., Gomez Cerezo, J., Ferrer, R., Diaz Santos, E., Cereto, F., Castro Guardiola, A., Bisbe, J., Barbagelata Lopez, C., Alvarez Sala, L. A., Mitha, I., Breedt, J., Basson, M., Adler, D., Spisakova, M., Prokop, D., Payer, J., Krastev, G., Kokles, M., Hrubon, A., Herman, O., Dvorak, M., Cervenakova, A., Bodikova, S., Miloradovic, V., Kovacevic-Kuzmanovic, A., Ilic, S., Celic, V., Apostolovic, S., Vishnevskiy, A., Vishneva, E., Solovyov, O., Simanenkov, V., Shvarts, Y., Shpagina, L., Shapovalova, Y., Sergeeva, E., Reshetko, O., Privalova, E., Popov, D., Nilk, R., Nikolaev, K., Mordovin, V., Maslova, N., Martynenko, V., Martynenko, T., Malygin, A., Kostenko, V., Kosmacheva, E., Kobalava, Z., Klein, G., Khachatryan, N., Goloshchekin, B., Ershova, O., Dovgalevskiy, Y., Chefranova, Z., Boldueva, S., Bogdanov, E., Belskaya, G., Barbarash, O., Averkov, O., Arkhipov, M., Apartsin, K., Andreev, D., Abashev, A., Vida-Simiti, L., Stanciulescu, G., Stamate, S., Harrington, Robert A., Goldhaber, Samuel Z., Hull, Russell D., Popescu, M., Wiens, Brian L., Gold, Alex, Hernandez, Adrian F., Gibson, C. Michael, Harrington, Robert, Hull, Russell, Goldhaber, Samuel, Hernandez, Adrian, Ceresetto, Jose Manuel, Colquhoun, David, Pilger, Ernst, Polonetsky, Leonid, Podoleanu, C., Musetescu, R., Marin, I., Bojinca, M., Motte, Serge, Saraiva, Jose Francisco, Balogh, Z. E., Wrzesinski, K., Waldemar, K., Walasek, L., Raev, Dimitar, Mincheva, Valentina, Kahn, Susan, Sulik, P., Canon, Claudia Olivares, Malojcic, Branko, Mayer, Otto, Husted, Steen, Marandi, Toomas, Lassila, Riitta, Mottier, Dominique, Shaburishvili, Tamaz, Bauersachs, Rupert, Zeymer, Uwe, Hajko, Erik, Sobkowicz, B., Zeltser, David, Ageno, Walter, Krievins, Dainis, Bagdonas, Alfredas, Osores, Juan Lema, Tomkowski, Witold, Mot, Stefan, Panchenko, Elizaveta, Tan, Ru San, Gaspar, Ludovit, Jacobson, Barry, Monreal, Manuel, Ongen, Gul, Parkhomenko, Alexander, Uprichard, James, Pulkowski, G., Mirek-Bryniarska, E., Kucharski, L., Jastrzebski, D., Yusen, Roger, Grzelakowski, P., Merli, Geno, Gruenpeter, P., Gorecka, D., Gniot, J., Gaciong, Z., Fryze, W., Peacock, Frank, Schellong, Sebastian, Januzzi, James, Piovella, Franco, Cochet, Madeleine, Michalak, Nathan, Stepanchak, Maria, Spielman, Kathryn, Neal, Brandon, Florea, Ana, Chi, Gerald, Szlosek, Donald, Jain, Purva, Popma, Christopher, Korjian, Serge, Daaboul, Yazan, Halaby, Rim, Yanez, L. Toche, Lemor, Alejandro, Zacarkim, Marcelo, Romero, Gonzalo, Hernandez Elenes, Jesus Rosario, Alvarado, Alonso, Susheela, Ammu, Leitao, Meghan, Salas, M., Bandman, Olga, Horna, M., Strumph, Peter, Vinh, Nancy, Visona, A., Kostadinova, M., Vance, Annemarie, Moia, M., Wiens, Brian, Orlandini, F., Parisi, R., Pontaga, N., Smoak, Carey, Storgaard, M., Molteni, M., Castelino, Rennie, Goodman, Shelly, Stukena, I., Leeds, Janet, al-Khalidi, Hussein, Milanova, M., Karlo, L. Farjardo, Leimberger, Jeffrey, Phillips, Thomas, Rizos, T., Pencheva, G., Pomero, F., Francis, Charles, Novo, S., Pereyra, R. Cotrina, Tiefenbacher, C., Buller, Harry, Roberts, Robin, Prins, Martin, Weimar, C., Tuxen, C., Urhammer, S., Lember, M., Runev, N., Uuetoa, T., Spyropoulos, Alex, Carrier, Marc, Alkonyi, B., Lopes, Renato D., Horacek, T., Airaksinen, J., Honkaniemi, J., Pottier, P., Falukozy, J., Kaaja, R., Stoeva, N., Saarinen, J., Stoyanov, M., Pizzini, A., Devor, Adam, Tatlisumak, T., Kolls, Bradley, Dedrick, Joseph, Todd, Jamie, Jones, William Schuyler, Vikman, S., Agraou, B., Futo, L., Castillo Leon, R., Eapen, Zubin, Katona, A., Proust, A., Quere, I., Kirschner, R., Syulemzova, S., Valavicius, A., Todorov, G., Tokmakova, M., Dhar, A., Klimpe, S., Ahmad, Tariq, Brenna, J. Matthew, Douketis, J., Le Gal, G., Pearce, M., Susinskiene, D., Brito, Flavio, Provencher, S., Rozitis, V., Roy, P-M., Kroning, R., Gulack, Brian, Schmidt, J., Meza, James, Parikh, Kishan, Cooper, Lauren, Poskiene, R., Aquilanti, S., Lapp, H., Kristof, P., Lakatos, F., Laszlo, Z., Belhassane, A., Petrauskiene, R., Pagidipati, Neha, Simoneau, G., Verreault, S., Guimaraes, Patricia, Brisot, D., Perkins, Lynn M., De Geeter, G., Debourdeau, P., Alarcon, M. Arias, Lupkovics, G., Norviliene, R., Wilson, Matthew, Merkely, B., Lazcano, M. Opazo, Collier, Jeannie, Andras, C. Nagy, Cardenas, S. Potthoff, Butkovic-Soldo, S., Norvaisiene, R., Decoulx, E., Hayden, Nikieia, El Kouri, D., Car, S., Nemeth, L., Leizorovicz, Alain, Ciglenecki, N., Naudziunas, A., Datikashvili-David, I., Francetic, I., Jakopovic, M., Becker, Francois, Jennings, Lisa, Khabeishvili, G., Bello, F., Ferrari, A. E., Jure, H., Macin, S., Griskeviciene, V., Kalinic-Grgorinic, H., Falvo, N., Khintibidze, I., Grange, C., Kobulia, B., Knezevic, A., Megreladze, I., Marusic, S., Papp, A., Pagava, Z., Lawall, H., Oliva, M., Paposhvili, K., Parody, M., Amann, B., Soltesz, P., Sudar, Z., Butkiene, Z., Szabo, G., Vagic, J. Sikic, Szegedi, N., Poy, C., Timar, G., Skerk, V., Cermak, O., Valco, J., Baker, R., Coughlin, P., Vertes, A., Rubinfeld, A., Elias, M., Berrouschot, J., Gafter, A., Hayek, T., Chlumsky, J., Lacroix, P., Messas, E., Chochola, J., Cizek, V., Basijokiene, V., Hussein, O., Dunaj, M., Dusek, J., Huber, K., Lishner, M., Lugassy, G., Cerveri, I., D'Angelo, A., De Pellegrin, A., Francek, L., Havelka, J., Konig, J., Beyer-Westendorf, J., Herold, M., Holaj, R., Imberti, D., Landolfi, R., Blessing, E., Mathies, R., Schoenerr, H., Adzerikho, I., Koryk, V., Licka, M., Martinova, V., Horny, I., Mikhailova, E., Mitkovskaya, N., Pimanov, S., Polonetsy, L., Soroka, N., Blockmans, D., Delforge, M., Dive, A., Lienart, F., Bizzacchi, J. Annichino, Fiss, E., Mismetti, P., Freire, A., Hubac, J., Jajtner, P., Manenti, E., Ramacciotti, E., Lembo, G., Raymuno, S., Rocha, A., Kolman, P., Lang, P., Bott, M., Dengler, T., Mikulova, J., Dimov, B., Podpera, I., Reiterer, P., Dziewas, R., Montaclair, K., Genth-Zotz, S., Hamann, F., Paleiron, N., Spacek, R., Payot, L., Vejvoda, J., Vyhnanek, M., Christensen, H., Salvi, A., Lodigiani, C., Pernod, G., Grigorov, M., Lassen, M., Mumoli, N., Kalpachki, R., Kamenova, Z., Schenone, A., Guy's and St Thomas' Hospital [London], Stanford Medicine, Stanford University, Brigham and Women's Hospital [Boston], Thrombosis Research Unit, University of Calgary, Portola Pharmaceuticals (Portola), PORTOLA PHARMACEUTICALS, Division of Cardiology, Duke University Medical Center, Duke Clinical Research Institute (DCRI - DURHAM), Duke University [Durham], Beth Israel Deaconess Medical Center [Boston, USA], Harvard Medical School [Boston] (HMS), Groupe d'Etude de la Thrombose de Bretagne Occidentale (GETBO), Institut Brestois Santé Agro Matière (IBSAM), Université de Brest (UBO)-Université de Brest (UBO)-Université de Brest (UBO), Centre d'Investigation Clinique (CIC - Brest), Université de Brest (UBO)-Institut National de la Santé et de la Recherche Médicale (INSERM), Université de Brest (UBO)-Institut Brestois Santé Agro Matière (IBSAM), and Université de Brest (UBO)-Université de Brest (UBO) more...

Subjects
Male, Pyridines, Medizin, 030204 cardiovascular system & hematology, law.invention, chemistry.chemical_compound, 0302 clinical medicine, Randomized controlled trial, Risk Factors, law, 030212 general & internal medicine, ComputingMilieux_MISCELLANEOUS, Ultrasonography, Venous Thrombosis, Factors de risc en les malalties, Medicine (all), Acute Disease, Adult, Aged, Benzamides, Double-Blind Method, Drug Administration Schedule, Factor Xa Inhibitors, Female, Fibrin Fibrinogen Degradation Products, Hemorrhage, Hospitalization, Humans, Middle Aged, Pulmonary Embolism, Venous Thromboembolism, General Medicine, 3. Good health, Pulmonary embolism, Venous thrombosis, Cohort, medicine.medical_specialty, Patients, Risk factors in diseases, Placebo, 03 medical and health sciences, [SDV.MHEP.CSC]Life Sciences [q-bio]/Human health and pathology/Cardiology and cardiovascular system, Internal medicine, Thromboembolism, medicine, Pacients, Betrixaban, Thromboprophylaxis, Acutely Ill Medical Patients, Tromboembolisme, business.industry, Settore MED/09 - MEDICINA INTERNA, ta3121, Population cohort, medicine.disease, Surgery, chemistry, Once daily, business
Abstract

Background\ud Patients with acute medical illnesses are at prolonged risk for venous thrombosis. However, the appropriate duration of thromboprophylaxis remains unknown.\ud \ud Methods\ud Patients who were hospitalized for acute medical illnesses were randomly assigned to receive subcutaneous enoxaparin (at a dose of 40 mg once daily) for 10±4 days plus oral betrixaban placebo for 35 to 42 days or subcutaneous enoxaparin placebo for 10±4 days plus oral betrixaban (at a dose of 80 mg once daily) for 35 to 42 days. We performed sequential analyses in three prespecified, progressively inclusive cohorts: patients with an elevated d-dimer level (cohort 1), patients with an elevated d-dimer level or an age of at least 75 years (cohort 2), and all the enrolled patients (overall population cohort). The statistical analysis plan specified that if the between-group difference in any analysis in this sequence was not significant, the other analyses would be considered exploratory. The primary efficacy outcome was a composite of asymptomatic proximal deep-vein thrombosis and symptomatic venous thromboembolism. The principal safety outcome was major bleeding.\ud \ud Results\ud A total of 7513 patients underwent randomization. In cohort 1, the primary efficacy outcome occurred in 6.9% of patients receiving betrixaban and 8.5% receiving enoxaparin (relative risk in the betrixaban group, 0.81; 95% confidence interval [CI], 0.65 to 1.00; P=0.054). The rates were 5.6% and 7.1%, respectively (relative risk, 0.80; 95% CI, 0.66 to 0.98; P=0.03) in cohort 2 and 5.3% and 7.0% (relative risk, 0.76; 95% CI, 0.63 to 0.92; P=0.006) in the overall population. (The last two analyses were considered to be exploratory owing to the result in cohort 1.) In the overall population, major bleeding occurred in 0.7% of the betrixaban group and 0.6% of the enoxaparin group (relative risk, 1.19; 95% CI, 0.67 to 2.12; P=0.55).\ud \ud Conclusions\ud Among acutely ill medical patients with an elevated d-dimer level, there was no significant difference between extended-duration betrixaban and a standard regimen of enoxaparin in the prespecified primary efficacy outcome. However, prespecified exploratory analyses provided evidence suggesting a benefit for betrixaban in the two larger cohorts. (Funded by Portola Pharmaceuticals; APEX ClinicalTrials.gov number, NCT01583218. opens in new tab.) more...

Published
2016
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