Search

Your search keyword '"Bendix, Knud"' showing total 39 results
Start Over Author "Bendix, Knud" Search Limiters Full Text
39 results on '"Bendix, Knud"'

7. Proteomic profiling identifies outcome-predictive markers in patients with peripheral T-cell lymphoma, not otherwise specified

Author

Ludvigsen, Maja, primary, Bjerregård Pedersen, Martin, additional, Lystlund Lauridsen, Kristina, additional, Svenstrup Poulsen, Tim, additional, Hamilton-Dutoit, Stephen Jacques, additional, Besenbacher, Søren, additional, Bendix, Knud, additional, Møller, Michael Boe, additional, Nørgaard, Peter, additional, d’Amore, Francesco, additional, and Honoré, Bent, additional

Published
2018
Full Text
View/download PDF

8. DUSP22 and TP63 rearrangements predict outcome of ALK-negative anaplastic large cell lymphoma:a Danish cohort study

Author

Pedersen, Martin Bjerregård, Hamilton-Dutoit, Stephen Jacques, Bendix, Knud, Ketterling, Rhett P, Bedroske, Patrick P, Luoma, Ivy M, Sattler, Christopher A, Boddicker, Rebecca L, Bennani, N Nora, Nørgaard, Peter, Møller, Michael Boe, Steiniche, Torben, d'Amore, Francesco, Feldman, Andrew L, Pedersen, Martin Bjerregård, Hamilton-Dutoit, Stephen Jacques, Bendix, Knud, Ketterling, Rhett P, Bedroske, Patrick P, Luoma, Ivy M, Sattler, Christopher A, Boddicker, Rebecca L, Bennani, N Nora, Nørgaard, Peter, Møller, Michael Boe, Steiniche, Torben, d'Amore, Francesco, and Feldman, Andrew L

Published
2017

11. HLA Associations and Risk of Posttransplant Lymphoproliferative Disorder in a Danish Population-Based Cohort

Author

Vase, Maja Ølholm, primary, Maksten, Eva Futtrup, additional, Strandhave, Charlotte, additional, Søndergaard, Esben, additional, Bendix, Knud, additional, Hamilton-Dutoit, Stephen, additional, Andersen, Claus, additional, Møller, Michael Boe, additional, Sørensen, Søren Schwartz, additional, Kampmann, Jan, additional, Eiskjær, Hans, additional, Iversen, Martin, additional, Weinreich, Ilse Duus, additional, Møller, Bjarne, additional, Jespersen, Bente, additional, and d'Amore, Francesco, additional

Published
2015
Full Text
View/download PDF

12. Proteomic Analysis Identifies Outcome-Predictive Clusters in Patients with Peripheral T-Cell Lymphoma, Not Otherwise Specified

Author

Ludvigsen, Maja, primary, Pedersen, Martin Bjerregaard, additional, Hamilton-Dutoit, Stephen Jacques, additional, Bendix, Knud, additional, Møller, Michael Boe, additional, Nørgaard, Peter H., additional, Poulsen, Tim Svenstrup, additional, Besenbacher, Søren, additional, d'Amore, Francesco, additional, and Honoré, Bent, additional

Published
2014
Full Text
View/download PDF

13. Identification of a Subset of Peripheral T-Cell Lymphoma, Not Otherwise Specified, Characterized By FOXP3-Positive Regulatory T-Cell Phenotype, HTLV-1 Negativity and Poor Outcome

Author

Pedersen, Martin Bjerregaard, primary, Hamilton-Dutoit, Stephen Jacques, additional, Bendix, Knud, additional, Nørgaard, Peter H., additional, Michael, Møller Boe, additional, Raffeld, Mark, additional, Pittaluga, Stefania, additional, Steiniche, Torben, additional, Bergmann, Anke, additional, Vater, Inga, additional, Siebert, Reiner, additional, Chan, Wing-Chung, additional, and d'Amore, Francesco, additional

Published
2014
Full Text
View/download PDF

14. Tumor Microenvironmental Features and Outcome in Post-Transplant Lymphoproliferative Disorder

Author

Vase, Maja Ølholm, primary, Maksten, Eva, additional, Bendix, Knud, additional, Hamilton-Dutoit, Stephen Jacques, additional, Andersen, Claus, additional, Møller, Michael B., additional, Sørensen, Søren Schwartz, additional, Jespersen, Bente, additional, Kampmann, Jan, additional, Rabinovich, Gabriel, additional, Søndergård, Esben, additional, Nielsen, Patricia Switten, additional, and d'Amore, Francesco, additional

Published
2014
Full Text
View/download PDF

15. Clinical Outcome Determinants for Sequentially Transformed Indolent Lymphomas Treated with or without Autologous Stem Cell Transplantation

Author

Madsen, Charlotte, primary, Pedersen, Martin Bjerregaard, additional, Vase, Maja Ølholm, additional, Segel, Erik, additional, Bendix, Knud, additional, Jensen, Bo Amdi, additional, Jensen, Paw, additional, Moeller, Michael Boe, additional, Johansen, Preben, additional, Munksgaard, Lars, additional, Brown, Peter de Nully, additional, and d'Amore, Francesco, additional

Published
2014
Full Text
View/download PDF

16. Reasons for treating secondary AML as de novo AML

Author

Ostgård, Lene Sofie Granfeldt, Kjeldsen, Eigil, Holm, Mette Skov, Brown, Peter De Nully, Pedersen, Bjarne Bach, Bendix, Knud, Johansen, Preben, Kristensen, Jørgen Schøler, Nørgaard, Jan Maxwell, Ostgård, Lene Sofie Granfeldt, Kjeldsen, Eigil, Holm, Mette Skov, Brown, Peter De Nully, Pedersen, Bjarne Bach, Bendix, Knud, Johansen, Preben, Kristensen, Jørgen Schøler, and Nørgaard, Jan Maxwell

Abstract

In a Danish bi-regional registry-based study, we conducted an analysis of the incidence and clinical importance of secondary acute myeloid leukaemia (AML). In a total of 630 cases of AML, we found 157 (25%) cases of secondary AML. The secondary leukaemia arose from MDS (myelodysplastic syndrome) in 77 cases (49%), CMPD (chronic myeloproliferative disorder) in 43 cases (27%) and was therapy-related AML (t-AML) in 37 cases (24%). Median age at diagnosis of AML was 69 yr in secondary cases when compared to 66 yr in de novo cases (P = 0.006). In univariate analyses, secondary AML was associated with an inferior complete remission (CR) rate (P = 0.008) and poorer overall survival (OS, P = 0.003) whereas in complete remitters, disease-free survival (DFS) of secondary cases was equal to that of de novo cases. Interestingly, in all further analyses of CR-rates, OS and DFS, when correcting for the influence of age, cytogenetic abnormalities, performance status and leucocyte count (WBC), presence of secondary AML completely lost prognostic significance. We conclude that the presence of secondary AML does not per se convey an unfavourable prognosis and that patients with secondary AML should be offered the chance of benefiting from treatment according to current frontline AML protocols.

Published
2010

23. Different Cytogenetic Patterns in Specified Categories of Secondary AML: Results of a Population-Based Registry Study,

Author

Norgaard, Jan M., primary, Oestgaard, Lene S.G., additional, Andersen, Mette K., additional, Kallenbach, Maria, additional, Johansen, Preben, additional, Bendix, Knud, additional, Kerndrup, Gitte, additional, Preiss, Birgitte, additional, Dufva, Inge, additional, Timshel, Susanne, additional, Kristensen, Joergen, additional, and Brown, Peter de Nully, additional

Published
2011
Full Text
View/download PDF

24. Development of a Splenic Marginal Zone Lymphoma Associated with Active Chronic Visceral Leishmaniasis

Author

Vase, Maja Ølholm, primary, Hellberg, Ylva Kristina, additional, Larsen, Carsten Schade, additional, Petersen, Jørgen Eskild, additional, Schaumburg, Henrik, additional, Bendix, Knud, additional, Ravel, Christophe, additional, Bastien, Patrick, additional, Christensen, Mariann, additional, Nyvold, Charlotte Guldborg, additional, and d'Amore, Francesco, additional

Published
2011
Full Text
View/download PDF

28. Laser-assisted microdissection of membrane-mounted paraffin sections for polymerase chain reaction analysis:Identification of cell populations using immunohistochemistry and in situ hybridization

Author

Gjerdrum, Lise Mette, Lielpetere, Ilze, Rasmussen, Lars Melholt, Bendix, Knud, Hamilton-Dutoit, Stephen, Gjerdrum, Lise Mette, Lielpetere, Ilze, Rasmussen, Lars Melholt, Bendix, Knud, and Hamilton-Dutoit, Stephen

Abstract

Laser microbeam microdissection (LMM) is an increasingly important method for obtaining pure cell samples for genetic and proteomic analysis. Immuno-histochemistry (IHC) and in situ hybridization (ISH) are useful techniques for targeting specific cell populations for microdissection but are difficult to apply with the tissue support membranes often used during LMM. Using detection of cytokeratins and Epstein-Barr virus gene products in head and neck carcinoma as a model, we describe optimized protocols for membrane and section preparation and for low temperature antigen retrieval that allow IHC and ISH to be used reliably on membrane mounted paraffin tissue sections. Visualization of cellular targets was markedly improved by staining and this could be further improved using a variety of optical media before microdissection. Tissue fragments thus stained were suitable for subsequent polymerase chain reaction analysis of extracted DNA using standard techniques. These IHC and ISH procedures are generally applicable and will be useful for detecting a wide range of antigens and nucleic acids in paraffin sections in conjunction with LMM.

Published
2001

30. Expression Pattern and Prognostic Impact of Vascular Endothelial Growth Factors VEGF and VEGF-C and Their Receptors Flt-1, KDR and Flt-4 in Peripheral T-Cell Lymphomas.

Author

Jørgensen, Judit M., primary, Sørensen, Flemming B., additional, Bendix, Knud, additional, Nielsen, Johan L., additional, Funder, Anette D., additional, Tainola, Tapio, additional, Karkkainen, Marika, additional, Sørensen, Annette B., additional, Pedersen, Finn S., additional, Kühle, Astrid V., additional, and d’Amore, Francesco, additional

Published
2007
Full Text
View/download PDF

37. High Intratumoral Galectin-1 Is Associated with Adverse Outcome in ALK-Negative, CD30-Positive Peripheral T-Cell Lymphomas

Author

Holst, Johanne Marie, Ludvigsen, Maja, Dutoit, Stephen, Bendix, Knud, Plesner, Trine Lindhardt, Noergaard, Peter, Møller, Michael Boe, Steiniche, Torben, Rabinovich, Gabriel, d'Amore, Francesco, and Pedersen, Martin Bjerregård

Abstract

Galectin-1 (Gal-1) has been associated with prognosis in several cancers including lymphomas. CD30-dependent cell signaling mediated by Gal-1 has been proposed in CD30-positive lymphomas and cell lines. Still, Gal-1 expression has not been systematically assessed as a possible prognosticator in nodal peripheral T-cell lymphomas (PTCL).

Published
2017
Full Text
View/download PDF

38. Acute renal failure and normal blood count: A rare presentation of T-cell acute lymphoblastic leukemia.

Author

Asdahl PH, Warner LF, Bendix K, and Hasle H

Abstract

A 10-year-old boy presented with headache and visual disturbance. During work-up in hospital he developed acute renal failure with a maximum creatinine level of 534 μmol/l. Complete blood count was normal. Kidney and bone marrow biopsy both showed massive infiltration of lymphoblasts of T-cell linage. Renal function normalized rapidly on prednisolone therapy. Kidney involvement in acute lymphoblastic leukemia is uncommon and renal failure due to leukemic infiltration is only sporadically reported. This case emphasizes the importance of kidney and bone marrow biopsy in cases of unexplained acute renal failure even with normal hematology.

Published
2013
Full Text
View/download PDF

39. Tumor-infiltrating macrophages correlate with adverse prognosis and Epstein-Barr virus status in classical Hodgkin's lymphoma.

Author

Kamper P, Bendix K, Hamilton-Dutoit S, Honoré B, Nyengaard JR, and d'Amore F

Subjects
Adolescent, Adult, Aged, Aged, 80 and over, Child, Epstein-Barr Virus Infections complications, Epstein-Barr Virus Infections virology, Female, Herpesvirus 4, Human isolation & purification, Hodgkin Disease metabolism, Hodgkin Disease pathology, Humans, Immunoenzyme Techniques, In Situ Hybridization, Fluorescence, Macrophages immunology, Male, Middle Aged, Pilot Projects, Prognosis, Survival Rate, Tissue Array Analysis, Validation Studies as Topic, Young Adult, Antigens, CD metabolism, Antigens, Differentiation, Myelomonocytic metabolism, Antineoplastic Combined Chemotherapy Protocols therapeutic use, Biomarkers, Tumor metabolism, Epstein-Barr Virus Infections diagnosis, Hodgkin Disease virology, Macrophages pathology, Receptors, Cell Surface metabolism
Abstract

Background: Classical Hodgkin's lymphoma is characterized by a minority of neoplastic cells surrounded by a heterogeneous background population of non-neoplastic cells including lymphoma-associated macrophages. High levels of expression of both the monocyte/macrophage lineage-associated antigens CD68 and CD163 have been suggested to have pro-tumor effects. The aim of our study was to correlate expression of CD68 and CD163 with the clinico-pathological features and prognosis of a cohort of patients with previously untreated Hodgkin's lymphoma., Design and Methods: A tissue microarray was constructed from paraffin-embedded tumor tissues from 288 cases of classical Hodgkin's lymphoma. CD68 and CD163 expression was assessed immunohistochemically and the degree of macrophage infiltration within the tumor was scored using point grid counting. Clinical data were obtained from clinical records., Results: The patients' median age was 37 years (range, 6-86 years). The male to female ratio was 1.2. In classical Hodgkin's lymphoma (n = 288) high CD68 and CD163 expression correlated, at the univariate level, with poorer overall survival (P=0.002 and P=0.03, respectively) and event-free survival (P=0.03 and P=0.04, respectively). At the multivariate level, high CD68 expression remained significantly predictive of overall survival (P=0.004). In addition, we demonstrated that both high CD68 and CD163 expression were associated with the presence of Epstein-Barr virus in the neoplastic cells (P=0.001 and P=0.0002, respectively)., Conclusions: In classical Hodgkin's lymphoma, high expression of the macrophage/monocyte-related antigens CD68 and CD163 correlates with adverse outcome and with the presence of Epstein-Barr virus in the tumor cell population.

Published
2011
Full Text
View/download PDF

Catalog

Books, media, physical & digital resources
See catalog results