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6. Optimization of an O2-balanced bioartificial pancreas for type 1 diabetes using statistical design of experiment.

Author

Mouré, Anne, Bekir, Sawsen, Bacou, Elodie, Pruvost, Quentin, Haurogné, Karine, Allard, Marie, De Beaurepaire, Laurence, Bosch, Steffi, Riochet, David, Gauthier, Olivier, Blancho, Gilles, Soulillou, Jean-Paul, Poncelet, Denis, Mignot, Grégoire, Courcoux, Philippe, Jegou, Dominique, Bach, Jean-Marie, and Mosser, Mathilde

Subjects
TYPE 1 diabetes, ISLANDS of Langerhans, EXPERIMENTAL design, ARTIFICIAL pancreases, RESPONSE surfaces (Statistics), PANCREAS, ISLANDS
Abstract

A bioartificial pancreas (BAP) encapsulating high pancreatic islets concentration is a promising alternative for type 1 diabetes therapy. However, the main limitation of this approach is O2 supply, especially until graft neovascularization. Here, we described a methodology to design an optimal O2-balanced BAP using statistical design of experiment (DoE). A full factorial DoE was first performed to screen two O2-technologies on their ability to preserve pseudo-islet viability and function under hypoxia and normoxia. Then, response surface methodology was used to define the optimal O2-carrier and islet seeding concentrations to maximize the number of viable pseudo-islets in the BAP containing an O2-generator under hypoxia. Monitoring of viability, function and maturation of neonatal pig islets for 15 days in vitro demonstrated the efficiency of the optimal O2-balanced BAP. The findings should allow the design of a more realistic BAP for humans with high islets concentration by maintaining the O2 balance in the device. [ABSTRACT FROM AUTHOR]

Published
2022
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7. Additional file 2: of Effects of divergent selection upon adrenocortical activity on immune traits in pig

Author

HervÊ, Julie, Terenina, Elena, HaurognÊ, Karine, Bacou, Elodie, Kulikova, Elizaveta, Allard, Marie, Billon, Yvon, Bach, Jean-Marie, MormèDe, Pierre, and Lieubeau, Blandine

Abstract

Table S1. Variableâ s contributions to the first two dimensions of the PCA. Variables that contributed to more than 10% to one axis are underlined. (PDF 35 kb)

Published
2019
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8. Additional file 1: of Effects of divergent selection upon adrenocortical activity on immune traits in pig

Author

Hervé, Julie, Terenina, Elena, Haurogné, Karine, Bacou, Elodie, Kulikova, Elizaveta, Allard, Marie, Billon, Yvon, Bach, Jean-Marie, Mormède, Pierre, and Lieubeau, Blandine

Abstract

Figure S1. PCA variables’ correlogram. Correlations of each variable to the first two dimensions of the PCA are shown. CTL, CD8αhi cytotoxic T lymphocytes. (PDF 129 kb)

Published
2019
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9. Additional file 3: of Effects of divergent selection upon adrenocortical activity on immune traits in pig

Author

Hervé, Julie, Terenina, Elena, Haurogné, Karine, Bacou, Elodie, Kulikova, Elizaveta, Allard, Marie, Billon, Yvon, Bach, Jean-Marie, Mormède, Pierre, and Lieubeau, Blandine

Subjects
3. Good health
Abstract

Figure S2. Gating strategy for non B-lymphocyte subsets analysis. Representative flow cytometry profile is shown. Nucleated single cells were identified as DRAQ5-positive cells. Among SSC-Alo cells, CD4/CD8α/CD3 co-staining allowed the determination of 6 lymphocyte subsets as mentioned on the plots. (PDF 935 kb)

10. Additional file 3: of Effects of divergent selection upon adrenocortical activity on immune traits in pig

Author

Hervé, Julie, Terenina, Elena, Haurogné, Karine, Bacou, Elodie, Kulikova, Elizaveta, Allard, Marie, Billon, Yvon, Bach, Jean-Marie, Mormède, Pierre, and Lieubeau, Blandine

Subjects
3. Good health
Abstract

Figure S2. Gating strategy for non B-lymphocyte subsets analysis. Representative flow cytometry profile is shown. Nucleated single cells were identified as DRAQ5-positive cells. Among SSC-Alo cells, CD4/CD8α/CD3 co-staining allowed the determination of 6 lymphocyte subsets as mentioned on the plots. (PDF 935 kb)

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