80 results on '"Andrzej Janusz"'
Search Results
2. Method for leak detection and location for gas networks
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Kwestarz, Małgorzata Amanda, primary, Osiadacz, Andrzej Janusz, additional, and Kotyński, Łukasz, additional
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- 2023
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3. Learning multimodal entity representations and their ensembles, with applications in a data-driven advisory framework for video game players
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Andrzej Janusz, Daniel Kałuża, Maciej Matraszek, Łukasz Grad, Maciej Świechowski, and Dominik Ślęzak
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Information Systems and Management ,Artificial Intelligence ,Control and Systems Engineering ,Software ,Computer Science Applications ,Theoretical Computer Science - Published
- 2022
4. The influence of HIP process on critical parameters of MgB2/Fe wires with big boron grains and without barriers
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Gajda, Daniel, Morawski, Andrzej, Zaleski, Andrzej Janusz, Akdoğan, Mustafa, Yetiş, Hakan, Karaboğa, Fırat, Cetner, Tomasz, and Belenli, Ibrahim
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- 2016
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5. BrightBox — A rough set based technology for diagnosing mistakes of machine learning models
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Andrzej Janusz, Andżelika Zalewska, Łukasz Wawrowski, Piotr Biczyk, Jan Ludziejewski, Marek Sikora, and Dominik Ślęzak
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Software - Published
- 2023
6. Various manifestations of weak magnetism and superconductivity in inclination interfaces of Bi, Sb and Bi1-xSbx
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Muntyanu Fiodor M., Nenkov Konstantin A., Zaleski Andrzej Janusz, Condrea Elena, and Chistol Vitalie
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Antimony ,superconductivitate și ferromagnetism ,TK7800-8360 ,Physics ,QC1-999 ,bismut ,interfață bicristalină ,stibiu ,aliaje bismut-stibiu ,izolator topologic 3D ,Bicrystal interface ,bismuth–antimony alloys ,3D topological insulator ,Electronics ,Bismuth ,Superconductivity and ferromagnetism - Abstract
The magnetic properties of the nano-width bicrystal interfaces (CIs) of Bi, Sb and 3D topological insulator Bi1xSbx (0.06 ≤ x ≤ 0.2) are studied in a temperature range of 1.6–300 K. These materials do not show superconductivity under normal rhombohedral conditions and are anomalous diamagnetics. At the same time, two superconducting phases with Tc ≤ 21 K and magnetic hysteresis loops against a diamagnetic background typical for strong type II superconductors are identified in Bi interfaces. At the CIs of Bi1xSbx (0.06 ≤ x ≤ 0.2), as well as Sb, a superconducting transition and a ferromagnetic hysteresis loop or a dual loop (superimposed ferromagnetic and superconducting loops) against a paramagnetic background are observed; they indicate the simultaneous occurrence of superconductivity and weak ferromagnetism, which is specific to 3D topological insulators. The revealed coexistence of superconductivity and weak magnetism at these CIs is of significant interest for the fundamental physics and future applications in quantum computing and spintronic devices.Proprietățile magnetice ale interfețelor bicristaline (CIs) de nano-lățime din Bi, Sb și 3D izolator topologic Bi1-xSbx (0,06≤x≤0,2) au fost studiate în intervalul de temperatură 1.6-300K. Aceste materiale nu prezintă supraconductibilitate în condiții romboedrice normale și sunt diamagnetici anormali. În același timp, două faze supraconductoare cu Tc ≤21K și bucle de istereză magnetică pe un fundal diamagnetic tipic pentru superconductorii puternici de tip II au fost identificate în interfețele Bi. În CIs ale Bi1-xSbx (0,06≤x≤0,2), precum și ale Sb s-au observat tranziții supraconductoare și bucle de istereză feromagnetică sau bucle duale (bucle feromagnetice și de tip supraconductor suprapuse) pe un fundal paramagnetic, indicând prezenţa simultană a supraconductivității și feromagnetismului slab, specificâ izolatorilor topologici 3D. Coexistența supraconductivității și a magnetismului slab in aceste CIs manifestă un interes sporit pentru fizica fundamentală și aplicațiile viitoare în computing cuantic și dispozitive spintronice.
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- 2021
7. KnowledgePit Meets BrightBox: A Step Toward Insightful Investigation of the Results of Data Science Competitions
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Andrzej Janusz and Dominik Ślęzak
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- 2022
8. Physicians’ attitudes toward beta‐blockers for the treatment of hypertension in Italy, Poland, and Turkey
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Aleksander Prejbisz, Francesca Donnaloja, Piotr Dobrowolski, Alessia Tettamanti, Andrzej Januszewicz, Mehdi Zoghi, and Claudio Ferri
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antihypertensive agents ,hypertension ,nebivolol ,survey ,β‐blockers ,Diseases of the circulatory (Cardiovascular) system ,RC666-701 - Abstract
Abstract Despite substantial progress in understanding the complex pathophysiology, hypertension remains a serious public health challenge affecting over 1.2 billion adults aged 30–79 years worldwide. Appropriate knowledge of the different pharmaceutical classes of antihypertensive agents and an understanding of the characteristics of individual molecules are essential to optimize clinical outcomes in patients with hypertension. We conducted a computer‐assisted web interviewing (CAWI) quantitative survey in Italy, Poland, and Turkey to investigate physicians’ prescriptions, knowledge, and perceptions of antihypertensive drugs with a focus on β‐blockers, to assess antihypertensive usage patterns and the reasons underlying prescription choices. The survey findings show that β‐blockers retain a pivotal role in the management of hypertension and are prescribed more often for patients with cardiovascular comorbidities than for patients with diabetic comorbidities. In all three countries, nebivolol is the only β‐blocker among the ones analyzed which is consistently prescribed to 20% or more of patients and is overall the most prescribed one for the population with comorbid diabetes. In terms of specific β‐blockers’ features, this study revealed knowledge gaps that underline the need for educational activities focused on the differences among β‐blockers, which are important in choosing the most suitable agent for individualized antihypertensive therapy.
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- 2024
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9. Randomised, double-blind, placebo-controlled study evaluating the effect of allopurinol on the risk of cardiovascular events in patients with high and very high cardiovascular risk, including the presence of long-COVID-19 syndrome: the ALL-VASCOR study protocol
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Krzysztof Narkiewicz, Aleksander Prejbisz, Andrzej Januszewicz, Katarzyna Lewandowska, Dawid Lipski, Paweł Uruski, Jacek Wolf, Marek Rajzer, Andrzej Więcek, and Andrzej Tykarski
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Medicine - Abstract
Introduction Numerous studies, but not all, have suggested a positive effect of allopurinol on the cardiovascular system. The randomised, double-blind, placebo-controlled study evaluating the effect of allopurinol on the risk of cardiovascular events in patients with high and very high cardiovascular risk, including the presence of long-COVID-19 syndrome (ALL-VASCOR) study aims to evaluate the efficacy of allopurinol therapy for improving cardiovascular outcomes in patients at high and very high cardiovascular risk excluding ischaemic heart disease. This is particularly important due to the high cost of cardiovascular disease treatment and its status as one of the leading causes of mortality.Methods and analysis The ALL-VASCOR study is a randomised, double-blind, placebo-controlled, multicentre trial that examines the effect of allopurinol therapy (200–500 mg of allopurinol daily) versus an equivalent dose of placebo on the risk of cardiovascular events in 1116 patients aged 40–70 with serum uric acid levels above 5 mg/dL at high and very high risk of cardiovascular disease. The ALL-VASCOR study will also assess the occurrence of long-COVID-19 syndrome. The study will measure primary and secondary as well as additional endpoints and the planned intervention will end on 31 July 2028 unless advised otherwise by the Safe Monitoring Board or other applicable authorities. Participant recruitment is planned to begin in March 2024 in Poland.Ethics and dissemination The study was ethically approved by the Bioethics Committee of Poznan University of Medical Sciences (No 03/23, 12 January 2023). The results are expected after 2028 and will be disseminated in peer-reviewed journals and at international conferences.Protocol version number 01–15 November 2022.Trial registration number EudraCT: 2022-003573-32, 27 October 2022, ClinicalTrials: NCT05943821, 13 July 2023.
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- 2024
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10. Why were the 2023 Guidelines of the European Society of Hypertension not developed as Joint Guidelines together with the European Society of Cardiology?
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Reinhold Kreutz, Michel Azizi, Guido Grassi, Andrzej Januszewicz, Thomas Kahan, Empar Lurbe, Jorge Polonia, Konstantinos Tsioufis, Thomas Weber, Bryan Williams, and Giuseppe Mancia
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Diseases of the circulatory (Cardiovascular) system ,RC666-701 - Published
- 2024
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11. Network Device Workload Prediction: A Data Mining Challenge at Knowledge Pit
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Andrzej Janusz, Piotr Biczyk, Mateusz Przyborowski, and Dominik Slezak
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Computer science ,Association (object-oriented programming) ,020208 electrical & electronic engineering ,02 engineering and technology ,Workload prediction ,computer.software_genre ,Networking hardware ,Competition (economics) ,Upload ,020204 information systems ,0202 electrical engineering, electronic engineering, information engineering ,Data mining ,Baseline (configuration management) ,computer - Abstract
We describe the 7th edition of the international data mining competition held at Knowledge Pit in association with the FedCSIS conference series. The goal was to predict workload-related characteristics of monitored network devices. We analyze solutions uploaded by the most successful participants. We investigate prediction errors which had the greatest influence on their results. We also present our own baseline solution which turned out to be the most reliable in the final evaluation.
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- 2020
12. On Positive-Correlation-Promoting Reducts
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Joanna Henzel, Andrzej Janusz, Marek Sikora, and Dominik Ślęzak
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Discrete mathematics ,0209 industrial biotechnology ,Rule induction ,Binary number ,Feature selection ,02 engineering and technology ,Positive correlation ,R package ,020901 industrial engineering & automation ,Knowledge extraction ,0202 electrical engineering, electronic engineering, information engineering ,020201 artificial intelligence & image processing ,Rough set ,Row ,Mathematics - Abstract
We introduce a new rough-set-inspired binary feature selection framework, whereby it is preferred to choose attributes which let us distinguish between objects (cases, rows, examples) having different decision values according to the following mechanism: for objects u1 and u2 with decision values \(dec(u1)=0\) and \(dec(u2)=1\), it is preferred to select attributes a such that \(a(u1)=0\) and \(a(u2)=1\), with the secondary option – if the first one is impossible – to select a such that \(a(u1)=1\) and \(a(u2)=0\). We discuss the background for this approach, originally inspired by the needs of the genetic data analysis. We show how to derive the sets of such attributes – called positive-correlation-promoting reducts (PCP reducts in short) – using standard calculations over appropriately modified rough-set-based discernibility matrices. The proposed framework is implemented within the RoughSets R package which is widely used for the data exploration and knowledge discovery purposes.
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- 2020
13. A framework for learning and embedding multi-sensor forecasting models into a decision support system: A case study of methane concentration in coal mines
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Marek Sikora, Dominik Ślęzak, Andrzej Janusz, Łukasz Wróbel, Marek Grzegorowski, Michał Kozielski, Sebastian Stawicki, and Sinh Hoa Nguyen
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Decision support system ,Information Systems and Management ,Computer science ,business.industry ,Feature extraction ,Coal mining ,02 engineering and technology ,computer.software_genre ,Computer Science Applications ,Theoretical Computer Science ,Task (project management) ,Data set ,Artificial Intelligence ,Control and Systems Engineering ,Feature (computer vision) ,Analytics ,020204 information systems ,0202 electrical engineering, electronic engineering, information engineering ,Embedding ,020201 artificial intelligence & image processing ,Data mining ,business ,computer ,Software - Abstract
We introduce a new approach for learning forecasting models over large multi-sensor data sets, including the steps of sliding-window-based feature extraction and rough-set-inspired feature subset ensemble selection. We show how to integrate this approach with the major data-processing-related components of DISESOR – a decision support system which is a coherent and complete framework for exploring streams of sensor readings registered in underground coal mines. As a case study, we report our experiments related to the task of methane concentration forecasting. The contributions in this paper refer to both the analysis how the nature of sensor readings influenced the architecture of the developed system and the empirical proof that the designed methods for data processing and analytics turned out to be efficient in practice.
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- 2018
14. Association of adrenal steroids with metabolomic profiles in patients with primary and endocrine hypertension
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Robin Knuchel, Zoran Erlic, Sven Gruber, Laurence Amar, Casper K. Larsen, Anne-Paule Gimenez-Roqueplo, Paolo Mulatero, Martina Tetti, Alessio Pecori, Christina Pamporaki, Katharina Langton, Mirko Peitzsch, Filippo Ceccato, Aleksander Prejbisz, Andrzej Januszewicz, Christian Adolf, Hanna Remde, Livia Lenzini, Michael Dennedy, Jaap Deinum, Emily Jefferson, Anne Blanchard, Maria-Christina Zennaro, Graeme Eisenhofer, and Felix Beuschlein
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metabolomics ,adrenal steroids ,endocrine hypertension ,primary hypertension ,pheochromocytoma ,primary aldosteronism ,Diseases of the endocrine glands. Clinical endocrinology ,RC648-665 - Abstract
IntroductionEndocrine hypertension (EHT) due to pheochromocytoma/paraganglioma (PPGL), Cushing’s syndrome (CS), or primary aldosteronism (PA) is linked to a variety of metabolic alterations and comorbidities. Accordingly, patients with EHT and primary hypertension (PHT) are characterized by distinct metabolic profiles. However, it remains unclear whether the metabolomic differences relate solely to the disease-defining hormonal parameters. Therefore, our objective was to study the association of disease defining hormonal excess and concomitant adrenal steroids with metabolomic alterations in patients with EHT.MethodsRetrospective European multicenter study of 263 patients (mean age 49 years, 50% females; 58 PHT, 69 PPGL, 37 CS, 99 PA) in whom targeted metabolomic and adrenal steroid profiling was available. The association of 13 adrenal steroids with differences in 79 metabolites between PPGL, CS, PA and PHT was examined after correction for age, sex, BMI, and presence of diabetes mellitus.ResultsAfter adjustment for BMI and diabetes mellitus significant association between adrenal steroids and metabolites – 18 in PPGL, 15 in CS, and 23 in PA – were revealed. In PPGL, the majority of metabolite associations were linked to catecholamine excess, whereas in PA, only one metabolite was associated with aldosterone. In contrast, cortisone (16 metabolites), cortisol (6 metabolites), and DHEA (8 metabolites) had the highest number of associated metabolites in PA. In CS, 18-hydroxycortisol significantly influenced 5 metabolites, cortisol affected 4, and cortisone, 11-deoxycortisol, and DHEA each were linked to 3 metabolites.DiscussionsOur study indicates cortisol, cortisone, and catecholamine excess are significantly associated with metabolomic variances in EHT versus PHT patients. Notably, catecholamine excess is key to PPGL’s metabolomic changes, whereas in PA, other non-defining adrenal steroids mainly account for metabolomic differences. In CS, cortisol, alongside other non-defining adrenal hormones, contributes to these differences, suggesting that metabolic disorders and cardiovascular morbidity in these conditions could also be affected by various adrenal steroids.
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- 2024
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15. Decision bireducts and decision reducts – a comparison
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Dominik Ślęzak, Sebastian Widz, Andrzej Janusz, and Sebastian Stawicki
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Computational complexity theory ,business.industry ,Applied Mathematics ,010102 general mathematics ,Decision tree ,Evidential reasoning approach ,02 engineering and technology ,Decision rule ,Machine learning ,computer.software_genre ,01 natural sciences ,Theoretical Computer Science ,Artificial Intelligence ,Simple (abstract algebra) ,0202 electrical engineering, electronic engineering, information engineering ,Influence diagram ,020201 artificial intelligence & image processing ,Artificial intelligence ,0101 mathematics ,business ,Completeness (statistics) ,computer ,Software ,Optimal decision ,Mathematics - Abstract
In this paper we revise the notion of decision bireducts. We show new interpretations and we prove several important and practically useful facts regarding this notion. We also explain the way in which some of the well-known algorithms for computation of decision reducts can be modified for the purpose of computing decision bireducts. For the sake of completeness of our study we extend our investigations to relations between decision bireducts and so-called approximate decision reducts. We compare different formulations of those two approaches and draw analogies between them. We also report new results related to NP-hardness of searching for optimal decision bireducts and approximate decision reducts from data. Finally, we present new results of empirical tests which demonstrate usefulness of decision bireducts in a construction of efficient, yet simple ensembles of classification models.
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- 2017
16. Clash Royale Challenge: How to Select Training Decks for Win-rate Prediction
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Andrzej Janusz, Marek Grzegorowski, and Lukasz Grad
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Scope (project management) ,Computer science ,Association (object-oriented programming) ,02 engineering and technology ,010501 environmental sciences ,Collision ,01 natural sciences ,Data science ,Training (civil) ,Task (project management) ,Competition (economics) ,020204 information systems ,Active learning ,0202 electrical engineering, electronic engineering, information engineering ,Information system ,0105 earth and related environmental sciences - Abstract
We summarize the sixth data mining competition organized at the Knowledge Pit platform in association with the Federated Conference on Computer Science and Information Systems series, titled Clash Royale Challenge: How to Select Training Decks for Win-rate Prediction. We outline the scope of this challenge and briefly present its results. We also discuss the problem of acquiring knowledge about new notions from video games through an active learning cycle. We explain how this task is related to the problem considered in the challenge and share results of experiments that we conducted to demonstrate usefulness of the active learning approach in practice.
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- 2019
17. The Hypertension Excellence Centre programme of the European Society of Hypertension – current status, activities and reshaping for the future
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Thomas Weber, Michael Doumas, Christian Delles, Bojan Jelakovic, Margus Viigimaa, Krzysztof Narkiewicz, Andrzej Januszewicz, Reinhold Kreutz, Guido Grassi, and Giuseppe Mancia
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european society of hypertension ,excellence centre ,hypertension ,research ,Diseases of the circulatory (Cardiovascular) system ,RC666-701 - Abstract
Purpose To describe the history of the Excellence Centre (EC) programme of the European Society of Hypertension (ESH) since the beginning in 2006, its achievements, and its future developments. Materials and Methods We list the number of ECs per country, the research projects performed so far, and the organisational steps needed to reshape the EC programme for the future. Results In August 2023, the ESH EC programme includes 118 registered ECs in 21 European and 7 non-European countries. Updates about the formal steps for application, re-application, transfer of EC and retirement of EC heads are given. Conclusions The EC programme of the ESH has been a success from the beginning. Further refinements will make it fit for the next decades.
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- 2023
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18. Toward an Intelligent HS Deck Advisor: Lessons Learned from AAIA'18 Data Mining Competition
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Jacek Puczniewski, Tomasz Tajmajer, Andrzej Janusz, Dominik Slezak, Lukasz Grad, and Maciej Swiechowski
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Artificial neural network ,Scope (project management) ,Computer science ,02 engineering and technology ,010501 environmental sciences ,computer.software_genre ,01 natural sciences ,Deck ,Task (project management) ,Competition (economics) ,0202 electrical engineering, electronic engineering, information engineering ,Task analysis ,020201 artificial intelligence & image processing ,Data mining ,computer ,0105 earth and related environmental sciences - Abstract
We summarize AAIA'18 Data Mining Competition organized at the Knowledge Pit platform. We explain the competition's scope and outline its results. We also review several approaches to the problem of representing Hearthstone decks in a vector space. We divide such approaches into categories based on a type of the data about individual cards that they use. Finally, we outline experiments aiming to evaluate usefulness of various deck representations for the task of win-rates prediction.
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- 2018
19. Improving Hearthstone AI by Combining MCTS and Supervised Learning Algorithms
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Andrzej Janusz, Tomasz Tajmajer, and Maciej Swiechowski
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FOS: Computer and information sciences ,Computer Science - Machine Learning ,Artificial neural network ,Computer science ,Heuristic ,business.industry ,Computer Science - Artificial Intelligence ,ComputingMilieux_PERSONALCOMPUTING ,02 engineering and technology ,Machine learning ,computer.software_genre ,Machine Learning (cs.LG) ,Prediction algorithms ,Tree (data structure) ,Artificial Intelligence (cs.AI) ,020204 information systems ,0202 electrical engineering, electronic engineering, information engineering ,020201 artificial intelligence & image processing ,State (computer science) ,Artificial intelligence ,business ,Video game ,computer ,Supervised training - Abstract
We investigate the impact of supervised prediction models on the strength and efficiency of artificial agents that use the Monte-Carlo Tree Search (MCTS) algorithm to play a popular video game Hearthstone: Heroes of Warcraft. We overview our custom implementation of the MCTS that is well-suited for games with partially hidden information and random effects. We also describe experiments which we designed to quantify the performance of our Hearthstone agent's decision making. We show that even simple neural networks can be trained and successfully used for the evaluation of game states. Moreover, we demonstrate that by providing a guidance to the game state search heuristic, it is possible to substantially improve the win rate, and at the same time reduce the required computations., Proceedings of the 2018 IEEE Conference on Computational Intelligence and Games (CIG'18); pages 445-452; ISBN: 978-1-5386-4358-7
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- 2018
20. Implementing algorithms of rough set theory and fuzzy rough set theory in the R package 'RoughSets'
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Dominik Śle¸zak, Chris Cornelis, Francisco Herrera, Andrzej Janusz, José Manuel Benítez, Christoph Bergmeir, and Lala Septem Riza
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Information Systems and Management ,Discretization ,Computer science ,Rule induction ,Dominance-based rough set approach ,Feature selection ,computer.software_genre ,Computer Science Applications ,Theoretical Computer Science ,k-nearest neighbors algorithm ,Data modeling ,Artificial Intelligence ,Control and Systems Engineering ,Instance selection ,Rough set ,Data mining ,computer ,Algorithm ,Software - Abstract
The package RoughSets , written mainly in the R language, provides implementations of methods from the rough set theory (RST) and fuzzy rough set theory (FRST) for data modeling and analysis. It considers not only fundamental concepts (e.g., indiscernibility relations, lower/upper approximations, etc.), but also their applications in many tasks: discretization, feature selection, instance selection, rule induction, and nearest neighbor-based classifiers. The package architecture and examples are presented in order to introduce it to researchers and practitioners. Researchers can build new models by defining custom functions as parameters, and practitioners are able to perform analysis and prediction of their data using available algorithms. Additionally, we provide a review and comparison of well-known software packages. Overall, our package should be considered as an alternative software library for analyzing data based on RST and FRST.
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- 2014
21. Open cell foams Pd/Co3O4/ZrO2 catalyst for the lean combustion of methane
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Giuliana Ercolino, Carmen Williana Moncada Quintero, Gudyka, S., Stelmachowski, Pawel Jan, Kotarba, Andrzej Janusz, and Stefania Specchia
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- 2017
22. Helping AI to Play Hearthstone: AAIA'17 Data Mining Challenge
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Maciej Swiechowski, Tomasz Tajmajer, and Andrzej Janusz
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FOS: Computer and information sciences ,Artificial neural network ,Scope (project management) ,Computer Science - Artificial Intelligence ,Computer science ,Monte Carlo tree search ,Context (language use) ,02 engineering and technology ,computer.software_genre ,Intelligent agent ,Artificial Intelligence (cs.AI) ,Action (philosophy) ,Computer Science - Computer Science and Game Theory ,020204 information systems ,0202 electrical engineering, electronic engineering, information engineering ,020201 artificial intelligence & image processing ,Data mining ,computer ,Computer Science and Game Theory (cs.GT) - Abstract
This paper summarizes the AAIA'17 Data Mining Challenge: Helping AI to Play Hearthstone which was held between March 23, and May 15, 2017 at the Knowledge Pit platform. We briefly describe the scope and background of this competition in the context of a more general project related to the development of an AI engine for video games, called Grail. We also discuss the outcomes of this challenge and demonstrate how predictive models for the assessment of player's winning chances can be utilized in a construction of an intelligent agent for playing Hearthstone. Finally, we show a few selected machine learning approaches for modeling state and action values in Hearthstone. We provide evaluation for a few promising solutions that may be used to create more advanced types of agents, especially in conjunction with Monte Carlo Tree Search algorithms., Comment: Federated Conference on Computer Science and Information Systems, Prague (FedCSIS-2017) (Prague, Czech Republic)
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- 2017
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23. Rough Set Methods for Attribute Clustering and Selection
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Dominik Ślęzak and Andrzej Janusz
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Reduct ,business.industry ,Computer science ,Computation ,media_common.quotation_subject ,Machine learning ,computer.software_genre ,Artificial Intelligence ,Quality (business) ,Rough set ,Artificial intelligence ,Data mining ,Heuristics ,Greedy algorithm ,business ,Cluster analysis ,computer ,Selection (genetic algorithm) ,media_common - Abstract
In this study we investigate methods for attribute clustering and their possible applications to the task of computation of decision reducts from information systems. We focus on high-dimensional datasets, that is, microarray data. For this type of data, the traditional reduct construction techniques either can be extremely computationally intensive or can yield poor performance in terms of the size of the resulting reducts. We propose two reduct computation heuristics that combine the greedy search with a diverse selection of candidate attributes. Our experiments confirm that by proper grouping of similar—in some sense interchangeable—attributes, it is possible to significantly decrease computation time, as well as to increase a quality of the obtained reducts (i.e., to decrease their average size). We examine several criteria for attribute clustering, and we also identify so-called garbage clusters, which contain attributes that can be regarded as irrelevant.
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- 2014
24. Metabolic syndrome – a new definition and management guidelines. A joint position paper by the Polish Society of Hypertension, Polish Society for the Treatment of Obesity, Polish Lipid Association, Polish Association for Study of Liver, Polish Society of Family Medicine, Polish Society of Lifestyle Medicine, Division of Prevention and Epidemiology Polish Cardiac Society, 'Club 30' Polish Cardiac Society, and Division of Metabolic and Bariatric Surgery Society of Polish Surgeons
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Piotr Dobrowolski, Aleksander Prejbisz, Alina Kuryłowicz, Alicja Baska, Paweł Burchardt, Krzysztof Chlebus, Grzegorz Dzida, Piotr Jankowski, Jerzy Jaroszewicz, Paweł Jaworski, Karol Kamiński, Agnieszka Kapłon-Cieślicka, Marek Klocek, Michał Kukla, Artur Mamcarz, Agnieszka Mastalerz-Migas, Krzysztof Narkiewicz, Lucyna Ostrowska, Daniel Śliż, Wiesław Tarnowski, Jacek Wolf, Mariusz Wyleżoł, Tomasz Zdrojewski, Maciej Banach, Andrzej Januszewicz, and Paweł Bogdański
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Medicine - Published
- 2022
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25. Tagging Firefighter Activities at the Emergency Scene: Summary of AAIA’15 Data Mining Competition at Knowledge Pit
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Andrzej Janusz, Dominik Slezak, Adam Krasuski, Michal Meina, Krzysztof Rykaczewski, and Bartosz Celmer
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Competition (economics) ,Data set ,Units of measurement ,Decision support system ,Data acquisition ,Scope (project management) ,Process (engineering) ,Computer science ,Data mining ,computer.software_genre ,Wireless sensor network ,computer - Abstract
In this paper, we summarize AAIA'15 data mining competition: Tagging Firefighter Activities at a Fire Scene, which was held between March 9 and July 6, 2015. We describe the scope and background of the competition. We also reveal details regarding the data set used in the competition, which was collected and tagged specifically for the purpose of this data challenge. We explain the data acquisition process which involved using a body sensor network system consisting of several inertial measurement units and a physiological data sensor. Finally, we briefly discuss submitted results with respect to their possible real-life application in our decision support system.
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- 2015
26. Prevalence and clinical implications of atrial fibrillation in patients hospitalized due to COVID-19: Data from a registry in Poland
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Michał Terlecki, Wiktoria Wojciechowska, Marek Klocek, Tomasz Drożdż, Maryla Kocowska-Trytko, Paweł Lis, Christopher Pavlinec, Jan W. Pęksa, Michał Kania, Zbigniew Siudak, Andrzej Januszewicz, Reinhold Kreutz, Maciej Małecki, Tomasz Grodzicki, Marek Rajzer, and CraCov HHS Investigators
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atrial fibrillation ,COVID-19 ,prognosis ,anticoagulation ,NOAC drugs ,MACE ,Diseases of the circulatory (Cardiovascular) system ,RC666-701 - Abstract
BackgroundAtrial fibrillation (AF) is a common arrhythmia with increasing prevalence with respect to age and comorbidities. AF may influence the prognosis in patients hospitalized with Coronavirus disease 2019 (COVID-19). We aimed to assess the prevalence of AF among patients hospitalized due to COVID-19 and the association of AF and in-hospital anticoagulation treatment with prognosis.Methods and resultsWe assessed the prevalence of AF among patients hospitalized due to COVID-19 and the association of AF and in-hospital anticoagulation treatment with prognosis. Data of all COVID-19 patients hospitalized in the University Hospital in Krakow, Poland, between March 2020 and April 2021, were analyzed. The following outcomes: short-term (30-days since hospital admission) and long-term (180-days after hospital discharge) mortality, major cardiovascular events (MACEs), pulmonary embolism, and need for red blood cells (RBCs) transfusion, as a surrogate for major bleeding events during hospital stay were assessed. Out of 4,998 hospitalized patients, 609 had AF (535 pre-existing and 74 de novo). Compared to those without AF, patients with AF were older and had more cardiovascular disorders. In adjusted analysis, AF was independently associated with an increased risk of short-term {p = 0.019, Hazard Ratio [(HR)] 1.236; 95% CI: 1.035–1.476} and long-term mortality (Log-rank p
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- 2023
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27. METHOD FOR LEAK DETECTION AND LOCATION FOR GAS NETWORKS.
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KWESTARZ, MAŁGORZATA AMANDA, OSIADACZ, ANDRZEJ JANUSZ, and KOTYŃSKI, ŁUKASZ
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LEAK detection ,GAS leakage ,NATURAL gas pipelines ,GAS flow ,PIPELINES ,MATHEMATICAL models - Abstract
Leak detection in transmission pipelines is important for safe operation of pipelines. The probability of leaks may be occurred at any time and location, therefore pipeline leak detection systems play a key role in minimization of the occurrence of leaks probability and their impacts. During the operation of the network there are various accidents or intentional actions that lead to leaks of gas pipelines. For each network failure, a quick reaction is needed before it causes more damage. Methods that are used to detect such network failures are three-staged-: early identification of leakage, an accurate indication of its location and determine the amount of lost fluid. Methods for leak detection can be divided into two main groups: external methods (hardware) and internal methods (software). External leak detection methods require additional, often expensive equipment mounted on the network, or use systems that could display only local damage on the pipeline. The alternative are the internal methods which use available network measurements and signalling gas leakage signal based on the mathematical models of the gas flow. In this paper, a new method of leak detection based on a mathematical model of gas flow in a transient state has been proposed. [ABSTRACT FROM AUTHOR]
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- 2019
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28. Key Risk Factors for Polish State Fire Service: a Data Mining Competition at Knowledge Pit
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Adam Krasuski, Mariusz Rosiak, Andrzej Janusz, Hung Son Nguyen, Dominik Slezak, and Sebastian Stawicki
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Competition (economics) ,Service (systems architecture) ,Scope (project management) ,Order (exchange) ,Computer science ,Data analysis ,Key (cryptography) ,Context (language use) ,Data mining ,Architecture ,computer.software_genre ,computer - Abstract
In this paper we summarize AAIA'14 Data Mining Competition: Key risk factors for Polish State Fire Service which was held between February 3, 2014 and May 5, 2014 at the Knowledge Pit platform http://challenge.mimuw.edu.pl/. We describe the scope and background of this competition and we explain in details the evaluation procedure. We also briefly overview the results of this analytical challenge, showing the way in which those results can be beneficial to one of our other projects which is related to the problem of improving firefighter safety at a fire scene. Finally, we reveal some technical details regarding the architecture and functionalities of the Knowledge Pit competition platform, which we are developing in order to facilitate solving of practical problems that require advanced data analytics.
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- 2014
29. Genetic investigation of fibromuscular dysplasia identifies risk loci and shared genetics with common cardiovascular diseases
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Adrien Georges, Min-Lee Yang, Takiy-Eddine Berrandou, Mark K. Bakker, Ozan Dikilitas, Soto Romuald Kiando, Lijiang Ma, Benjamin A. Satterfield, Sebanti Sengupta, Mengyao Yu, Jean-François Deleuze, Delia Dupré, Kristina L. Hunker, Sergiy Kyryachenko, Lu Liu, Ines Sayoud-Sadeg, Laurence Amar, Chad M. Brummett, Dawn M. Coleman, Valentina d’Escamard, Peter de Leeuw, Natalia Fendrikova-Mahlay, Daniella Kadian-Dodov, Jun Z. Li, Aurélien Lorthioir, Marco Pappaccogli, Aleksander Prejbisz, Witold Smigielski, James C. Stanley, Matthew Zawistowski, Xiang Zhou, Sebastian Zöllner, FEIRI investigators, International Stroke Genetics Consortium (ISGC) Intracranial Aneurysm Working Group, MEGASTROKE, Philippe Amouyel, Marc L. De Buyzere, Stéphanie Debette, Piotr Dobrowolski, Wojciech Drygas, Heather L. Gornik, Jeffrey W. Olin, Jerzy Piwonski, Ernst R. Rietzschel, Ynte M. Ruigrok, Miikka Vikkula, Ewa Warchol Celinska, Andrzej Januszewicz, Iftikhar J. Kullo, Michel Azizi, Xavier Jeunemaitre, Alexandre Persu, Jason C. Kovacic, Santhi K. Ganesh, and Nabila Bouatia-Naji
- Subjects
Science - Abstract
Fibromuscular dysplasia is a cardiovascular disease affecting mostly women with a mostly unknown genetic basis. Here the authors have performed a genome-wide association meta-analysis of Fibromuscular dysplasia to identify genetic loci, some of which are shared with common cardiovascular disease and traits.
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- 2021
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30. Hypertension healthcare professional beliefs and behaviour regarding patient medication adherence: a survey conducted among European Society of Hypertension Centres of Excellence
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Michel Burnier, Aleksander Prejbisz, Thomas Weber, Michel Azizi, Vitoria Cunha, Jorie Versmissen, Pankaj Gupta, Jan Vaclavik, Andrzej Januszewicz, Alexandre Persu, Reinhold Kreutz, and on behalf of the Working Group on Cardiovascular Therapy and Adherence of the European Society of Hypertension
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adherence ,hypertension ,healthcare professionals ,pharmacotherapy ,chemical detection ,beliefs ,survey ,Diseases of the circulatory (Cardiovascular) system ,RC666-701 - Abstract
Purpose Little is known on the beliefs, perceptions and practices of hypertension specialists in addressing non-adherence to therapy. Therefore, a survey was undertaken amongst healthcare professionals (HCPs) managing hypertension in the European Society of Hypertension (ESH) Centres of Excellence. Materials and methods Cross-sectional data were obtained between December 2020 and April 2021 using an online anonymous structured questionnaire including 26 questions/136 items, that was sent to all ESH Excellence centres. Results Overall 67 from 187 centres (37.3%) responded and 200 HCPs from 30 countries answered the questionnaire. Participants (60% men) were mainly physicians (91%) and nurses (8%) from University hospitals (77%). Among physicians, 83% had >10 years professional experience. Average time dedicated to discuss medications was 1-5 min in 48% and 6-10 min in 29% of cases. Interviews with patients about adherence were the most frequently used assessment method. Chemical detection of medications in urine was available in 36% of centres. One third of physicians involved their patients regularly in treatment decisions. The most frequent methods to improve adherence included simplification of medication therapy, more frequent visits, and home blood pressure monitoring. Conclusions The level of implementation of tools to detect and improve adherence in hypertension management by HCPs in ESH excellence centres is low. Structured educational activities focussing on adherence management and access to the newest objective measures to detect non-adherence might improve these deficits.
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- 2021
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31. Optimized procedures for testing plasma metanephrines in patients on hemodialysis
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Christina Pamporaki, Aleksander Prejbisz, Robert Małecki, Frank Pistrosch, Mirko Peitzsch, Steffen Bishoff, Petra Mueller, Iris Meyer, Doreen Reimann, Katarzyna Hanus, Andrzej Januszewicz, Stefan R. Bornstein, Simon Parmentier, Carola Kunath, Jacques W. M. Lenders, Graeme Eisenhofer, and Jens Passauer
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Medicine ,Science - Abstract
Abstract Diagnosis of pheochromocytomas and paragangliomas in patients receiving hemodialysis is troublesome. The aim of the study was to establish optimal conditions for blood sampling for mass spectrometric measurements of normetanephrine, metanephrine and 3-methoxytyramine in patients on hemodialysis and specific reference intervals for plasma metanephrines under the most optimal sampling conditions. Blood was sampled before and near the end of dialysis, including different sampling sites in 170 patients on hemodialysis. Plasma normetanephrine concentrations were lower (P
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- 2021
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32. Imaging the eye and its relevance to diabetes care
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Nicola Quinn, Alicia Jenkins, Chris Ryan, Andrzej Januszewski, Tunde Peto, and Laima Brazionis
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Artificial intelligence ,Diabetic retinopathy ,Retinal vessels ,Diseases of the endocrine glands. Clinical endocrinology ,RC648-665 - Abstract
Abstract Diabetes is a major cause of vision loss globally, yet this devastating complication is largely preventable. Early detection and treatment of diabetic retinopathy necessitates screening. Ocular imaging is widely used clinically, both for the screening and management of diabetic retinopathy. Common eye conditions, such as glaucoma, cataracts and retinal vessel thrombosis, and signs of systemic conditions, such as hypertension, are frequently revealed. As well as imaging by a skilled clinician during an eye examination, non‐ophthalmic clinicians, such as general practitioners, endocrinologists, nurses and trained health workers, can also can carry out diabetic eye screening. This process usually comprises local imaging with remote grading, mostly human grading. However, grading incorporating artificial intelligence is emerging. In a clinical research context, retinal vasculature analyses using semi‐automated software in many populations have identified associations between retinal vessel geometry, such as vessel caliber, and the risk of diabetic retinopathy and other chronic complications of type 1 and type 2 diabetes. Similarly, evaluation of corneal nerves by corneal confocal microscopy is revealing diabetes‐related abnormalities, and associations with and predictive power for other chronic diabetes complications. As yet, the value of retinal vessel geometry and corneal confocal microscopy measures at an individual level is uncertain. In this article, targeting non‐ocular clinicians and researchers, we review existent and emerging ocular imaging and grading tools, including artificial intelligence, and their associations between ocular imaging findings and diabetes and its chronic complications.
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- 2021
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33. Intrarenal hemodynamics and kidney function in pheochromocytoma and paraganglioma before and after surgical treatment
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Magdalena Januszewicz, Piotr Dobrowolski, Andrzej Januszewicz, Ewa Warchoł-Celińska, Katarzyna Jóźwik-Plebanek, Daria Motyl, Marek Kabat, Mariola Pęczkowska, Ilona Michałowska, Urszula Ambroziak, Sadegh Toutounchi, Zbigniew Gałązka, Louisiane Courcelles, Marco Pappaccogli, Graeme Eisenhofer, Alexandre Persu, Jacques W. M. Lenders, Jacek Kądziela, and Aleksander Prejbisz
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pheochromocytoma and paraganglioma ,kidney ,renal resistance index ,ppgl ,catecholamines ,Diseases of the circulatory (Cardiovascular) system ,RC666-701 - Abstract
Purpose Current evidence regarding renal involvement in pheochromocytoma and paraganglioma (PPGL) is scant. More accurate diagnostic methods, such as renal Doppler ultrasound for intrarenal hemodynamic studies, may provide more detailed information on renal function. It might be postulated that renal function in PPGL patients might be altered by high blood pressure and excess secretion of catecholamines. The aim of this prospective study was to assess intrarenal blood flow parameters in PPGL patients included in the prospective monoamine-producing tumour (PMT) study and to evaluate the effects of normalisation of catecholamine production after surgical treatment on long-term renal function. Materials and methods Seventy consecutive patients (aged 46.5 ± 14.0 years) with PPGL were included. Forty-eight patients from the PMT study cohort, matched for age, gender, blood pressure level and presence of hypertension, served as a control group. Renal artery doppler ultrasound spectral analysis included mean resistance index (RRI) and pulsatility index (PI). Forty-seven patients completed 12 months follow-up. Results There were no differences in renal parameters such as RRI, PI and kidney function between PPGL and non-PPGL patients as assessed by renal ultrasound, serum creatinine, eGFR and albumin excretion rate. No correlations between kidney function parameters, intrarenal doppler flow parameters and plasma catecholamines were observed in PPGL patients. At 12 months after surgery, no differences in creatinine level, eGFR, albumin excretion rate, RI and PI were found as compared to baseline results. Conclusions In contrast to patients with other forms of secondary hypertension, our study did not show differences in intrarenal blood flow parameters and renal function between PPGL and non-PPGL subjects. Intrarenal hemodynamics and renal function did not change after normalisation of catecholamine levels by surgical treatment.
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- 2021
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34. Sinfonia Concertante For String Quartet and Orchestra
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Tereszkowski, Andrzej Janusz
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Andrzej Tereszkowski ,Sinfonia Concertante ,String Quartet no. 4 ,Contemporary Canadian Music ,String Quartet and Orchestra - Abstract
The primary goal o fSinfonia Concertante is to explore aformal design where a three movement chamber work is embedded within a larger, one movement orchestral composition. This unusualform presents a unique challenge, since the quartet is a completework in and ofitself, great care must be taken when adding orchestral interludes and layers on top ofthe string quartet t&preserveformal balance. The solution was tofirst compose the chamber work (i. Nocturne and Scherzando, ii. Humoresque, Hi. Metamorphosis), then to compose the connective orchestral materials (i. Introduction, ii. Intermezzo, Hi. Lullaby), and then to add a layer o f orchestral counterpoint on top o f the movements o f the string quartet. The end result is a truly original composition which, despite the challenges o f the design, achieves all the goals I set out to accomplish.
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- 2011
35. Improving reachability analysis of infinite state systems by specialization
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Andrzej Janusz, Fabio FIORAVANTI, Valerio Senni, Maurizio Proietti, and Alberto Pettorossi
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Algebra and Number Theory ,Theoretical computer science ,Computer science ,Relaxation (iterative method) ,Program transformation ,State (functional analysis) ,Abstract interpretation ,Satisfiability ,Program verification ,program transformation ,Theoretical Computer Science ,Transformation (function) ,Computational Theory and Mathematics ,Reachability ,Computer Science::Logic in Computer Science ,Specialization (logic) ,Constraint logic programming ,Settore ING-INF/05 - Sistemi di Elaborazione delle Informazioni ,Algorithm ,Reactive system ,Information Systems ,Real number ,Mathematics - Abstract
We consider infinite state reactive systems specified by using linear constraints over the integers, and we address the problem of verifying safety properties of these systems by applying reachability analysis techniques. We propose a method based on program specialization, which improves the effectiveness of the backward and forward reachability analyses. For backward reachability our method consists in: (i) specializing the reactive system with respect to the initial states, and then (ii) applying to the specialized system the reachability analysis that works backwards from the unsafe states. For reasons of efficiency, during specialization we make use of a relaxation from integers to reals. In particular, we test the satisfiability or entailment of constraints over the real numbers, while preserving the reachability properties of the reactive systems when constraints are interpreted over the integers. For forward reachability our method works as for backward reachability, except that the role of the initial states and the unsafe states are interchanged. We have implemented our method using the MAP transformation system and the ALV verification system. Through various experiments performed on several infinite state systems, we have shown that our specialization-based verification technique considerably increases the number of successful verifications without a significant degradation of the time performance.
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- 2011
36. RSCTC’2010 Discovery Challenge: Mining DNA Microarray Data for Medical Diagnosis and Treatment
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Lihe Guan, Ze Chen, Hung Son Nguyen, Vladimir Nikulin, Jan G. Bazan, Tian-Hsiang Huang, Guoyin Wang, Matko Bošnjak, Huan Luo, Marcin Wojnarski, Geoffrey J. McLachlan, Dragan Gamberger, Andrzej Janusz, Feng Hu, Juan Gao, Chuanjiang Luo, Yuanxia Shen, and Szczuka, M.
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Computer science ,Event (computing) ,Dna microarray data ,RSCTC'2010 ,Data Mining ,Challenge ,Microarray ,Medical Diagnosis ,Feature selection ,Anomaly detection ,Rough set ,Medical diagnosis ,Data science ,Task (project management) - Abstract
RSCTC'2010 Discovery Challenge was a special event of Rough Sets and Current Trends in Computing conference. The challenge was organized in the form of an interactive on-line competition, at TunedIT.org platform, in days between Dec 1, 2009 and Feb 28, 2010. The task was related to feature selection in analysis of DNA microarray data and classification of samples for the purpose of medical diagnosis or treatment. Prizes were awarded to the best solutions. This paper describes organization of the competition and the winning solutions.
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- 2010
37. Renal denervation: can we press the 'ON' button again in 2020?
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Jacek Kądziela, Ewa Warchoł-Celińska, Aleksander Prejbisz, Andrzej Januszewicz, Adam Witkowski, and Konstantinos Tsioufis
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renal denervation ,atrial fibrillation ,hypertension ,Medicine - Abstract
In December 2018, an article summarizing available results of randomized studies on renal denervation (RDN), entitled “Renal denervation: can we press the ON button again?” was published in the Advances in Interventional Cardiology. Since then, several positive reports, including SPYRAL HTN OFF-MED Pivotal trial have been presented. In the current review the authors discuss the latest data on RDN in arterial hypertension treatment and try to answer the burning question: can we press the ON button again in 2020? The results of recently published studies potentially justify new recommendations for the use of RDN in clinical practice in appropriately selected patients in the new hypertension guidelines. The current review also summarizes the results of trials on RDN applied in another potential indication – atrial fibrillation. Six most important, prospective, randomized trials assessing RDN as adjunct therapy to pulmonary vein isolation for treatment of atrial fibrillation were discussed. In 5 studies, patients had uncontrolled BP despite treatment with three antihypertensive agents. The ratio for recurrence of atrial fibrillation for pulmonary vein isolation with RDN procedure was reduced by 57% as compared to pulmonary vein isolation (PVI) alone. BP was also reduced significantly after RDN in this subset of patients. Further multicenter studies involving standardized PVI and RDN procedures are needed.
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- 2020
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38. MRS HEVELIUS — THE FIRST FEMALE ASTRONOMER IN POLAND
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ANDRZEJ JANUSZAJTIS
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Information technology ,T58.5-58.64 - Published
- 2021
39. Preanalytical Pitfalls in Untargeted Plasma Nuclear Magnetic Resonance Metabolomics of Endocrine Hypertension
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Nikolaos G. Bliziotis, Leo A. J. Kluijtmans, Gerjen H. Tinnevelt, Parminder Reel, Smarti Reel, Katharina Langton, Mercedes Robledo, Christina Pamporaki, Alessio Pecori, Josie Van Kralingen, Martina Tetti, Udo F. H. Engelke, Zoran Erlic, Jasper Engel, Timo Deutschbein, Svenja Nölting, Aleksander Prejbisz, Susan Richter, Jerzy Adamski, Andrzej Januszewicz, Filippo Ceccato, Carla Scaroni, Michael C. Dennedy, Tracy A. Williams, Livia Lenzini, Anne-Paule Gimenez-Roqueplo, Eleanor Davies, Martin Fassnacht, Hanna Remde, Graeme Eisenhofer, Felix Beuschlein, Matthias Kroiss, Emily Jefferson, Maria-Christina Zennaro, Ron A. Wevers, Jeroen J. Jansen, Jaap Deinum, and Henri J. L. M. Timmers
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confounders ,metabolomics ,multicenter ,plasma NMR ,preanalytical conditions ,Microbiology ,QR1-502 - Abstract
Despite considerable morbidity and mortality, numerous cases of endocrine hypertension (EHT) forms, including primary aldosteronism (PA), pheochromocytoma and functional paraganglioma (PPGL), and Cushing’s syndrome (CS), remain undetected. We aimed to establish signatures for the different forms of EHT, investigate potentially confounding effects and establish unbiased disease biomarkers. Plasma samples were obtained from 13 biobanks across seven countries and analyzed using untargeted NMR metabolomics. We compared unstratified samples of 106 PHT patients to 231 EHT patients, including 104 PA, 94 PPGL and 33 CS patients. Spectra were subjected to a multivariate statistical comparison of PHT to EHT forms and the associated signatures were obtained. Three approaches were applied to investigate and correct confounding effects. Though we found signatures that could separate PHT from EHT forms, there were also key similarities with the signatures of sample center of origin and sample age. The study design restricted the applicability of the corrections employed. With the samples that were available, no biomarkers for PHT vs. EHT could be identified. The complexity of the confounding effects, evidenced by their robustness to correction approaches, highlighted the need for a consensus on how to deal with variabilities probably attributed to preanalytical factors in retrospective, multicenter metabolomics studies.
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- 2022
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40. Prevalence of smoking and clinical characteristics in fibromuscular dysplasia. The ARCADIA-POL study
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Piotr Dobrowolski, Magdalena Januszewicz, Helena Witowicz, Ewa Warchoł-Celińska, Anna Klisiewicz, Urszula Skrzypczyńska-Banasik, Marek Kabat, Katarzyna Kowalczyk, Anna Aniszczuk-Hybiak, Elżbieta Florczak, Adam Witkowski, Andrzej Tykarski, Krystyna Widecka, Małgorzata Szczerbo-Trojanowska, Witold Śmigielski, Wojciech Drygas, Ilona Michałowska, Piotr Hoffman, Aleksander Prejbisz, and Andrzej Januszewicz
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smoking ,fibromuscular dysplasia ,hypertension ,target organ damage ,Diseases of the circulatory (Cardiovascular) system ,RC666-701 - Abstract
Purpose: Smoking was identified as a potential factor contributing to fibromuscular dysplasia (FMD). To evaluate the prevalence of smoking and clinical characteristics in FMD subjects. Material and Methods: We analysed 190 patients with confirmed FMD in at least one vascular bed. The rate of smokers in FMD patients was compared to that in two control groups selected from a nationwide survey. Results: The rate of smokers in FMD patients was 42.6%. There were no differences in frequency of smokers between FMD patients and: a group of 994 matched control subjects from general population and a group of matched hypertensive subjects. There were no differences in the characteristics of FMD (including rates of multisite FMD and significant renal artery stenosis) and its complications (including rates of dissections and aneurysms) between smokers and non-smokers. Smokers as compared with non-smokers were characterized by higher left ventricle mass index. Conclusions: There is no difference in the rate of smokers between FMD patients and subjects from the general population. Moreover, we did not find any association between smoking and clinical characteristics of FMD patients nor its extent and vascular complications. Our results do not support the hypothesis that smoking is involved in the pathophysiology of FMD.
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- 2019
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41. Author Correction: Genetic investigation of fibromuscular dysplasia identifies risk loci and shared genetics with common cardiovascular diseases
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Adrien Georges, Min-Lee Yang, Takiy-Eddine Berrandou, Mark K. Bakker, Ozan Dikilitas, Soto Romuald Kiando, Lijiang Ma, Benjamin A. Satterfield, Sebanti Sengupta, Mengyao Yu, Jean-François Deleuze, Delia Dupré, Kristina L. Hunker, Sergiy Kyryachenko, Lu Liu, Ines Sayoud-Sadeg, Laurence Amar, Chad M. Brummett, Dawn M. Coleman, Valentina d’Escamard, Peter de Leeuw, Natalia Fendrikova-Mahlay, Daniella Kadian-Dodov, Jun Z. Li, Aurélien Lorthioir, Marco Pappaccogli, Aleksander Prejbisz, Witold Smigielski, James C. Stanley, Matthew Zawistowski, Xiang Zhou, Sebastian Zöllner, FEIRI investigators, International Stroke Genetics Consortium (ISGC) Intracranial Aneurysm Working Group, MEGASTROKE, Philippe Amouyel, Marc L. De Buyzere, Stéphanie Debette, Piotr Dobrowolski, Wojciech Drygas, Heather L. Gornik, Jeffrey W. Olin, Jerzy Piwonski, Ernst R. Rietzschel, Ynte M. Ruigrok, Miikka Vikkula, Ewa Warchol Celinska, Andrzej Januszewicz, Iftikhar J. Kullo, Michel Azizi, ARCADIA Investigators, Xavier Jeunemaitre, Alexandre Persu, Jason C. Kovacic, Santhi K. Ganesh, and Nabila Bouatia-Naji
- Subjects
Science - Published
- 2022
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42. Renal denervation – can we press the 'ON' button again?
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Jacek Kądziela, Ewa Warchoł-Celińska, Aleksander Prejbisz, Andrzej Januszewicz, Adam Witkowski, and Konstantinos Tsioufis
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renal denervation ,resistant hypertension ,review ,Medicine - Abstract
Nearly ten years ago percutaneous renal denervation (RDN) was introduced in clinical trials as a possible method of interventional treatment of resistant hypertension. The promising results of the first clinical trials initiated the intensive development of this method. However, the role of percutaneous renal denervation in the treatment of patients with resistant hypertension has been questioned since the results of the Symplicity HTN-3 trial have been published. It also resulted in downgrading the indications for RDN in the European Society of Cardiology/European Society of Hypertension Guidelines 2018. The authors discuss potential shortcomings of that trial, describe new generation devices and present the results of recently published trials: SPYRAL HTN-OFF MED, SPYRAL HTN-ON MED, RADIANCE-HTN SOLO and RADIOSOUND-HTN. The results of studies in patients with obstructive sleep apnea are also summarized and discussed. The upcoming large trials (SPYRAL PIVOTAL, RADIANCE II) are outlined – the results of those trials are expected to be published in the next 2–3 years. Until then, according to the European guidelines, the use of device-based therapies is not recommended for the treatment of hypertension, unless in the context of clinical studies and randomized controlled trials.
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- 2018
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43. Missed clinical clues in patients with pheochromocytoma/paraganglioma discovered by imaging
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Natalie Rogowski-Lehmann, Aikaterini Geroula, Aleksander Prejbisz, Henri J L M Timmers, Felix Megerle, Mercedes Robledo, Martin Fassnacht, Stephanie M J Fliedner, Martin Reincke, Anthony Stell, Andrzej Januszewicz, Jacques W M Lenders, Graeme Eisenhofer, and Felix Beuschlein
- Subjects
pheochromocytoma ,paraganglioma ,imaging ,signs and symptoms ,prospective ,Diseases of the endocrine glands. Clinical endocrinology ,RC648-665 - Abstract
Background: Pheochromocytomas and paragangliomas (PPGLs) are rare but potentially harmful tumors that can vary in their clinical presentation. Tumors may be found due to signs and symptoms, as part of a hereditary syndrome or following an imaging procedure. Objective: To investigate potential differences in clinical presentation between PPGLs discovered by imaging (iPPGLs), symptomatic cases (sPPGLs) and those diagnosed during follow-up because of earlier disease/known hereditary mutations (fPPGL). Design: Prospective study protocol, which has enrolled patients from six European centers with confirmed PPGLs. Data were analyzed from 235 patients (37 iPPGLs, 36 sPPGLs, 27% fPPGLs) and compared for tumor volume, biochemical profile, mutation status, presence of metastases and self-reported symptoms. iPPGL patients were diagnosed at a significantly higher age than fPPGLs (P < 0.001), found to have larger tumors (P = 0.003) and higher metanephrine and normetanephrine levels at diagnosis (P = 0.021). Significantly lower than in sPPGL, there was a relevant number of self-reported symptoms in iPPGL (2.9 vs 4.3 symptoms, P < 0.001). In 16.2% of iPPGL, mutations in susceptibility genes were detected, although this proportion was lower than that in fPPGL (60.9%) and sPPGL (21.5%). Patients with PPGLs detected by imaging were older, have higher tumor volume and more excessive hormonal secretion in comparison to those found as part of a surveillance program. Presence of typical symptoms indicates that in a relevant proportion of those patients, the PPGL diagnosis had been delayed. Précis: Pheochromocytoma/paraganglioma discovered by imaging are often symptomatic and carry a significant proportion of germline mutations in susceptibility genes.
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- 2018
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44. HISTORY OF SCIENCE IN GDAŃSK - PART III
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ANDRZEJ JANUSZAJTIS
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history of science ,history of Gdańsk ,Information technology ,T58.5-58.64 - Abstract
This is the first part of the book entitled History of Science and Technology in Gdańsk, edited in 2014 for the 110th anniversary of the Gdańsk University of Technology (Politechnika Gdańska). It begins with a concise history of the local education with emphasis laid on schooling in the field of technology. It is followed by the history of the University of Technology founded in 1904 as German Hochschule but always having many Polish students. In 1945 it was transformed into a Polish university. The next sections are devoted to the prominent scientists of the old Gdańsk and their worldwide important achievements, not always sufficiently popularized. Many of them were members of foreign academies and scientific societies including the Royal Society of London. Then, the scientific societies of the past Gdańsk are presented, including but not limited to the Experimental Physics Society (later Naturforschende Gesellschaft), one of the first such institutions in the world. Last but not least, scientists of the beginning of the 20th century are presented as well as the pioneers of science in Gdańsk after World War II, who had to rebuild the destroyed infrastructure and create the scientific life in Gdańsk from scratch.
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- 2021
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45. Psychomotor hyperactivity: diagnostic criteria, unfolding over time, and difficulties at different stages of development
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Elżbieta Januszewska and Andrzej Januszewski
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diagnoza ADHD ,zaburzenia współwystępujące z ADHD ,Philosophy. Psychology. Religion ,Ethics ,BJ1-1725 - Abstract
Attention deficit hyperactivity disorder is most commonly diagnosed at school age, when it reveals itself through the difficulties children face in connection with such things as attention deficit, excessive hyperactivity and impulsiveness, all of which may problematize studying at school. It should be noted that the initial symptoms of ADHD, which may already be present in early childhood, can alter with age, and may also change according to situation. The aim of this article is to explore the diagnostic criteria for attention deficit hyperactivity disorder while giving special consideration to the different symptoms occurring at successive stages of child development and also outlining those behavioural and emotional disorders that co-occur with ADHD.
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- 2017
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46. Stent sizing strategies in renal artery stenting: the comparison of conventional invasive renal angiography with renal computed tomographic angiography
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Jacek Kadziela, Ilona Michalowska, Jerzy Pregowski, Hanna Janaszek-Sitkowska, Katarzyna Lech, Marek Kabat, Adam Staruch, Andrzej Januszewicz, and Adam Witkowski
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renal artery stenosis ,renal artery stenting ,computed tomographic angiography ,conventional angiography ,renovascular hypertension ,Medicine - Abstract
Introduction : Randomized trials comparing invasive treatment of renal artery stenosis with standard pharmacotherapy did not show substantial benefit from revascularization. One of the potential reasons for that may be suboptimal procedure technique. Aim : To compare renal stent sizing using two modalities: three-dimensional renal computed tomography angiography (CTA) versus conventional angiography. Material and methods: Forty patients (41 renal arteries), aged 65.1 ±8.5 years, who underwent renal artery stenting with preprocedural CTA performed within 6 months, were retrospectively analyzed. In CTA analysis, reference diameter (CTA-D) and lesion length (CTA_LL) were measured and proposed stent diameter and length were recorded. Similarly, angiographic reference diameter (ANGIO_D) and lesion length (ANGIO_LL) as well as proposed stent dimensions were obtained by visual estimation. Results: The median CTA_D was 0.5 mm larger than the median ANGIO_D (p < 0.001). Also, the proposed stent diameter in CTA evaluation was 0.5 mm larger than that in angiography (p < 0.0001). The median CTA_LL was 1 mm longer than the ANGIO_LL (p = NS), with significant correlation of these variables (r = 0.66, p < 0.0001). The median proposed stent length with CTA was equal to that proposed with angiography. The median diameter of the implanted stent was 0.5 mm smaller than that proposed in CTA (p < 0.0005) and identical to that proposed in angiography. The median length of the actual stent was longer than that proposed in angiography (p = 0.0001). Conclusions : Renal CTA has potential advantages as a tool adjunctive to angiography in appropriate stent sizing. Careful evaluation of the available CTA scans may be beneficial and should be considered prior to the planned procedure.
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- 2016
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47. Forty-two-year-old female patient with resistant hypertension, bilateral renal fibromuscular dysplasia and intracranial aneurysm
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Anna M. Kaszuba, Aleksander Prejbisz, Jacek Kądziela, Urszula Ambroziak, Małgorzata Szczerbo-Trojanowska, and Andrzej Januszewicz
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Medicine - Published
- 2016
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48. The issue of treatment-resistant hypertension in clinical practice
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Andrzej Januszewicz and Aleksander Prejbisz
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resistant hypertension ,occurrence ,causes ,diagnostics ,pharmacological treatment ,surgical treatment ,Medicine - Abstract
Resistant hypertension is defined as a clinical situation characterised by a failure to achieve lower systolic and diastolic blood pressure levels below 140 mm Hg and 90 mm Hg, respectively, despite the use of the principles of lifestyle modification as well as pharmacological treatment, including a diuretic as well as two other antihypertensives belonging to different groups, administered at adequate doses (mineralocorticoid receptor may not be included in the regimen). Previous studies suggest that the prevalence of resistant hypertension in the population of patients receiving antihypertensive treatment is 13%. According to a Polish nationwide survey NATPOL 2011, 13% of patients treated due to hypertension suffer from resistant hypertension. It was noted that factors predisposing and/or related to the development of resistant hypertension primarily include: advanced age, high/increased baseline blood pressure (systolic pressure in particular), obesity, excessive salt intake, chronic renal disease and diabetes. There is a consistent view that apart from non-compliance with lifestyle modification, an inadequate antihypertensive regimen and/or non-compliance with therapeutic indications are among the most common causes of treatment-resistant hypertension. Current recommendations for the management of patients with resistant hypertension also stress the importance of identifying the causes of secondary hypertension. This represents a very important element in the management of resistant hypertension and may facilitate pharmacological treatment. In the case of failure to achieve blood pressure target values, it is recommended to include a drug belonging to aldosterone receptor antagonists. If both, non-pharmacological and pharmacological therapies prove inefficient, surgical treatment of resistant hypertension may be considered in selected cases.
- Published
- 2014
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49. Effect of Arteriovenous Anastomosis on Blood Pressure Reduction in Patients With Isolated Systolic Hypertension Compared With Combined Hypertension
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Christian Ott, Melvin D. Lobo, Paul A. Sobotka, Felix Mahfoud, Alice Stanton, John Cockcroft, Neil Sulke, Eamon Dolan, Markus van der Giet, Joachim Hoyer, Stephen S. Furniss, John P. Foran, Adam Witkowski, Andrzej Januszewicz, Danny Schoors, Konstantinos Tsioufis, Benno J. Rensing, Manish Saxena, Benjamin Scott, G. André Ng, Stephan Achenbach, Roland E. Schmieder, Michael Schmid, Ajay Jain, Charles Knight, Anthony Mathur, Peter Balmforth, Sandra F. Luitjens, Gerard Smits, Dhanraj Mungur, Aleksander Prejbisz, Jacek Kadziela, Elżbieta Florczak, Joseph Galvin, and Kyriakos Dimitriadis
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arteriovenous anastomosis ,combined hypertension ,isolated systolic hypertension ,treatment resistant hypertension ,Diseases of the circulatory (Cardiovascular) system ,RC666-701 - Abstract
BackgroundOptions for interventional therapy to lower blood pressure (BP) in patients with treatment‐resistant hypertension include renal denervation and the creation of an arteriovenous anastomosis using the ROX coupler. It has been shown that BP response after renal denervation is greater in patients with combined hypertension (CH) than in patients with isolated systolic hypertension (ISH). We analyzed the effect of ROX coupler implantation in patients with CH as compared with ISH. Methods and ResultsThe randomized, controlled, prospective ROX Control Hypertension Study included patients with true treatment‐resistant hypertension (office systolic BP ≥140 mm Hg, average daytime ambulatory BP ≥135/85 mm Hg, and treatment with ≥3 antihypertensive drugs including a diuretic). In a post hoc analysis, we stratified patients with CH (n=31) and ISH (n=11). Baseline office systolic BP (177±18 mm Hg versus 169±17 mm Hg, P=0.163) and 24‐hour ambulatory systolic BP (159±16 mm Hg versus 154±11 mm Hg, P=0.463) did not differ between patients with CH and those with ISH. ROX coupler implementation resulted in a significant reduction in office systolic BP (CH: −29±21 mm Hg versus ISH: −22±31 mm Hg, P=0.445) and 24‐hour ambulatory systolic BP (CH: −14±20 mm Hg versus ISH: −13±15 mm Hg, P=0.672), without significant differences between the two groups. The responder rate (office systolic BP reduction ≥10 mm Hg) after 6 months was not different (CH: 81% versus ISH: 82%, P=0.932). ConclusionsOur data suggest that creation of an arteriovenous anastomosis using the ROX coupler system leads to a similar reduction of office and 24‐hour ambulatory systolic BP in patients with combined and isolated systolic hypertension. Clinical Trial RegistrationURL: http://www.clinicaltrials.gov. Unique identifier: NCT01642498.
- Published
- 2016
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50. A Clinical Efficacy of PRRT in Patients with Advanced, Nonresectable, Paraganglioma-Pheochromocytoma, Related to SDHx Gene Mutation
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Agnieszka Kolasinska-Ćwikła, Mariola Pęczkowska, Jarosław B. Ćwikła, Ilona Michałowska, Jakub M. Pałucki, Lisa Bodei, Anna Lewczuk-Myślicka, and Andrzej Januszewicz
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paraganglioma/pheochromocytoma (PPGL) ,peptide receptor radionuclide therapy (PRRT) ,SDHx genes mutation ,Medicine - Abstract
Paragangliomas and pheochromytomas (PPGLs) exhibit variable malignancy, advanced/hormonally active/progressive need therapy. PRRT (Peptide Receptor Radionuclide Therapy) could be an option for these patients. To evaluate the effectiveness of PRRT (90Y DOTATATE), based on overall survival (OS) and progression-free survival (PFS), in patients with PPGLs, related to SDHx gene mutation, we conducted a prospective open-label, single-center, phase II study. Thirteen patients were observed, eight PGL1 and five PGL4, all with advanced, non-resectable tumors, and eight had metastases. All were treated with 90Y DOTATATE. Efficacy was based on OS and PFS, and radiological response was based on RECIST. Hormonal activity was evaluated using serum-fractionated free catecholamines. Eight subjects had a clinical response, three were stable, and two exhibited disease progression. Among four patients with hormonally-active PPGLs, three showed a reduction and one showed normalization. OS for all was 68.0 months; PFS was 35.0 months. OS in PGL4 = 25.0 vs. N.R. (not reached) in PGL1. PFS in PGL4 = 12.0 vs. N.R. in PGL1. A difference was seen in the OS and PFS in patients who did not respond clinically, compared to those who did, OS = 22.0 vs. N.R. PFS = 7.0 vs. N.R. A difference in the OS and PFS was noted in patients with liver and bone involvement compared to those without. PRRT is an effective therapy in selected population of patients with SDHx, in those with locally-advanced, non-resectable tumors. Furthermore, it is effective regardless of the secretory status.
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- 2019
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