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目的探讨基因多态性对先天性心脏病儿童心脏介入手术中舒芬太尼（SUF）药代动力学的影响。方法选择年龄6~72月，ASA分级Ⅱ级并拟行心脏介入手术的患儿168例。使用丙泊酚2 mg·kg-1、SUF 0.3 μg·kg-1及苯磺顺阿曲库铵0.2 mg·kg-1行麻醉诱导，丙泊酚8 mg·kg-1·h-1维持麻醉。采用稀释采样法收集给予SUF后5、10、20、30、45、60、75、90 min的血液标本。使用UHPLC-MS/MS法测定血浆中SUF的药物浓度，并用Phoenix WinNonlinTM软件计算药代动力学参数。基因型检测采用基质辅助激光解析电离飞行时间质谱进行检测。应用SNPStats对基因型数据和药代动力学数据进行分析，选择赤池信息量准则数值最小的模型为最优模型。结果共纳入可能影响SUF药代动力学和药效学相关的靶点、代谢酶、转运体及通路相关的9个基因中30个单核苷酸多态性位点。发现基因ABCG2 rs2054576和OPRM1 rs4870266与SUF药物暴露量相关（P OPRM1 rs2236257与SUF表观分布容积相关（PCYP3A4 rs2246709和OPRM1 rs2236257，rs4870266与SUF药物清除率相关（PABCG2 rs2054576，CYP3A4 rs2246709和OPRM1 rs2236257，rs4870266的基因多态性可显著地影响SUF的药代动力学变化。

近年来，随着全球经济快速发展和城镇化加速，城市能耗及排放持续增长，面临严峻的资源短缺和环境污染问题。为满足城市居民多样化的能源需求，以及能源系统安全高效、清洁低碳的转型要求，城市能源系统应运而生，并迅速成为能源领域的研究热点。针对城市能源系统的规划设计及能耗分析，各国研究学者已经开发了一系列相关工具，然而各类工具的开发目的及开发者专业背景存在差异，其适用场景不尽相同，且模型的时间和空间颗粒度也存在较大差异。通过聚焦城市能源系统的规划设计及能耗分析工具，分别选取对比典型商用工具的功能和特性，并结合应用案例对工具的适用性进行分析，为相关工具的后续开发及应用提供参考。

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Summary Building a new development pattern is a strategic choice made in the light of China's own development stage and conditions, taking full account of economic globalization and changes in the external environment. It is an inevitable choice for China to rebuild its competitive advantage after entering a new development stage. In-depth exploration of the industrial policy system's evolution and main trends that adapt to the new development pattern is not only the need for actively responding to the actions of developed countries to suppress China with the stick of industrial policy. but also the need for promoting China's high-quality development. For more than 40 years since the reform and opening up, the main goal of industrial policy system has been to promote China's economic growth. The selective industrial policy committed to catching up with developed countries has promoted economic growth, but also caused great damage to the market environment of fair competition. Under the new development pattern, stimulating internal competition and strengthening external security have become the new main goals of industrial policy system. To build a new development pattern, industrial policy is still an indispensable tool for promoting domestic and international double circulation and promoting high-quality economic development due to great changes in internal and external environment and factors such as the development environment of the times and industrial policy objectives. However, the previous industrial policy objectives and pattern should be adjusted and upgraded. The narrow industrial policy which is represented by industrial structure policy and industrial development policy with selective characteristics, scientific and technological innovation policy and competition policy and some other polices together constitute the broad industrial policy system closely related to economic development, but the implications of above policies overlap. Based on the perspective of economic development stage, this paper clarifies the integration. coordination withdrawal and reconstruction of industrial policy, scientific and technological innovation policy and competition policy. And we clarify the evolution of the three types of policies in the four stages of economic development, and try to explore the basic role of various policies in the construction of new development pattern. The new development pattern that makes the national economy supply and demand to achieve a virtuous cycle is a dynamic process. It requires that industrial policy and competition policy, special science and technology innovation policy dedicated to overcome the"stuck neck" difficulties and conventional science and technology innovation policy are balanced and coordinated with each other. Based on the above analysis, this paper proposes that under the diversified policy goals of the new development pattern. the relationship between the three types of economic policies is not the opposite but the complementary and coordinated. And China's policy system should be structured as follows: competition policy should be the basis of all policies: industrial policy and competition policy coordinate with each other; selective industrial policy gradually gives way to functional industrial policy; science and technology policy pay more attention to the front of the innovation chain than the back and the new nationwide system keeps the selective character. Finally, this paper further puts forward some suggestions to improve the industrial policy system under the new development pattern. such as establishing anti-monopoly law enforcement agencies. establishing a multi-level policy coordination mechanism. improving the whole-process governance mechanism of industrial policy. The conclusion in this paper is of great significance for exploring what kind of industrial policy system is needed in the new development pattern and what is the evolution trend of China's industrial policy system in the future. It also provides institutional innovation impetus and important policy tools for China to build a new development pattern. [ABSTRACT FROM AUTHOR]

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Hydrodynamical interaction in circumbinary discs (CBDs) plays a crucial role in various astrophysical systems, ranging from young stellar binaries to supermassive black hole binaries in galactic centres. Most previous simulations of binary-disc systems have adopted locally isothermal equation of state. In this study, we use the grid-based code Athena++ to conduct a suite of two-dimensional viscous hydrodynamical simulations of circumbinary accretion on a Cartesian grid, resolving the central cavity of the binary. The gas thermodynamics is treated by thermal relaxation towards an equilibrium temperature (based on the constant − β cooling ansatz, where β is the cooling time in units of the local Keplerian time). Focusing on equal mass, circular binaries in CBDs with (equilibrium) disc aspect ratio H / R  = 0.1, we find that the cooling of the disc gas significantly influences the binary orbital evolution, accretion variability, and CBD morphology, and the effect depends sensitively on the disc viscosity prescriptions. When adopting a constant kinematic viscosity, a finite cooling time (β ≳ 0.1) leads to a binary inspiral as opposed to an outspiral and the CBD cavity becomes more symmetric. When adopting a dynamically varying α-viscosity, binary inspiral only occurs within a narrow range of cooling time (corresponding to β around 0.5). [ABSTRACT FROM AUTHOR]

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Aim To investigate the relationship between apolipoprotein E (ApoE) receptor 2 (ApoER2) degradation by proprotein convertase subtilisin kexin 9 (PCSK9) and the anti-inflammatory effect of ApoE/ApoER2. Methods Human umbilical vein endothelial cells (HUVEC) and HepG2 cells were cultured in vitro, Western blot and ELISA were used to detect the effects of lipopolysaccharide (LPS) on the expression and secretion of Toll-like receptor (TLR4), tumor necrosis factor-α (TNF-α), interleukin-6 (IL-6) and PCSK9 in HUVEC; the effects of ApoE3 on the expression and secretion of TNF-α, IL-6, PCSK9 and ApoER2 in HUVEC induced by LPS; the effects of three isoforms of ApoE (ApoE2, ApoE3 and ApoE4) on the expression of PCSK9 and ApoER2 in HUVEC and HepG2 cells under non-inflammatory conditions; and the effects of PCSK9 on the expression and secretion of ApoER2, TNF-α and IL-6 in HUVEC. Results Western blot and ELISA showed that LPS up-regulated the expression and secretion of TLR4, TNF-α, IL-6 and PCSK9 in HUVEC; ApoE3 inhibited LPS-induced inflammatory responses, and up-regulated ApoER2 expression and secretion; the three isoforms of ApoE (ApoE2, ApoE3 and ApoE4) had no effect on the expression of PCSK9 and ApoER2 in HUVEC and HepG2 cells under non-inflammatory conditions. Different doses (0, 0. 5, 1. 0 and 2. 5 mg/L) of recombinant human PCSK9 were used to treat HUVEC for 24 h, Western blot and ELISA showed that PCSK9 up-regulated the ex-pression and secretion of TNF-α and IL-6, and down-regulated the expression of ApoER2. Conclusion PCSK9 antagonizes the anti-inflammatory effects of ApoE/ApoER2 by degrading ApoER2. [ABSTRACT FROM AUTHOR]

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Objective To analyze clinical characteristics and risk factors of pulmonary infection caused by extensively drug-resistant Acinetobacter baumannii (XDRAB), evaluate antimicrobial therapy and prognosis of XDRAB patients, aiming to provide references for effective prevention and control of nosocomial infection and clinical diagnosis and treatment. Methods Patients with XDRAB isolated from the lower respiratory tract specimens were collected. The number of repeated cases and colonization strains were excluded. The case data were analyzed and summarized by the method of retrospective case analysis. Results A total of 210 XDRAB strains were detected. The distribution of clinical departments was mainly concentrated in the ICU, with 108 cases (51.4%). Respiratory diseases (OR = 2.294, 95% CI: 1.018-5.170, P < 0.05), carbapenems (OR = 12.723, 95% CI: 4.585-35.306, P < 0.05), quinolones (OR= 10.100, 95% CI: 1.950-52.317, P < 0.05), β-lactam inhibitors (OR = 4.012, 95% CI: 1.659-9.702, P < 0.05) were the independent risk factors for XDRAB infection. The non-improvement rate in the XDRAB group was higher than that in the non-XDRAB group (χ² = 94.500, P < 0.05). Conclusions The proportion of XDRAB isolated from the ICU is the highest. Respiratory diseases and antibacterial drugs (carbapenems, β-lactam inhibitors, quinolones) are the independent risk factors for XDRAB infection. The prognosis of XDRAB infected patients is poor. [ABSTRACT FROM AUTHOR]

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This paper first systematically describes the theoretical mechanism of the digital economy affecting economic growth and income inequality, then calculates and analyzes the development trend of regional Gini coefficient and regional differences, and finally carries out an empirical test based on China’s provincial panel data. The study shows that:（1） the annual average Gini coefficient in China from 2010-2018 shows a trend of rising and then falling, and has significant regional heterogeneity, in which the income gap is the smallest in the northeast, followed by the east and central, while the west is the most severe.（2） The development of China’s digital economy can balance efficiency and equity. Specifically, every 1% increase in the digital economy will significantly contribute to a 0.053 unit increase in per capita income and a significant 0.046 unit decrease in the Gini coefficient.（3） The regional heterogeneity test shows that digital economy is conducive to improving the per capita income level and narrowing the income gap in various regions, and the impact effect is that the low-income group is better than the middle-income group and better than the high-income group.（4） Time heterogeneity test shows that the impact of digital economy on per capita income is significantly positive in both stages, but the boosting effect in the second stage is significantly higher than that in the first stage; the impact of digital economy on income inequality is significantly positive in the first stage and significantly negative in the second stage.（5） The mechanism test shows that promoting individual employment opportunities and improving family income are important channels for the digital economy to reduce income inequality. This study provides policy implications for China to grasp the opportunities of digital economy development and achieve the goal of common prosperity with a balance of efficiency and equity. [ABSTRACT FROM AUTHOR]

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Copyright of Journal of Shanghai Jiaotong University (Medical Science) is the property of Journal of Shanghai Jiaotong University (Medical Science) and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)

Copyright of Food Research & Development is the property of Food Research & Development Editorial Department and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)

To control the formation of polycyclic aromatic hydrocarbons (PAHs) and reduce the carbon deposition phenomenon on the surface of oxygen earner, the mechanical mixing method to prepare CaSO4/bentonite oxygen carrier was adopted to react with coal in a simulated chemical-looping combustion (CLC) fuel reactor. Gas chromatography was employed for qualitative and quantitative analysis on PAHs. The emission characteristics of PAHs were discussed at different coal types, temperatures and oxygen carriers/coal ratios. The results show that with the volatile increasing, the total amount of PAHs formation at different coal types is in the order as anthracite< bituminous coal 1< bituminous coal 2< bituminous coal 3. PAHs formation is also influenced by carbon content, n( H )/n( C ) and n( O )/n( C ) ratio. In the CLC process, 2-ring and 3-ring PAHs are predominant as 4-ring and 5-ring PAHs are relatively small, while 6- ring PAHs is not produced. When the temperature is 900 ℃ and oxygen carrier/coal ratio is 2. 4, the total amount of PAHs formation is the least in the reaction of CaSO4/bentonite oxygen earner and bituminous coal 3. [ABSTRACT FROM AUTHOR]

The ultra-fine grinding kinetic model for pulverized coal based on the mechanism of grinding process can be used to predict the particle size distribution of the products in the grinding process, provide a guidance for optimizing the mill efficiency, and reduce the process energy consumption. It is very important for the preparation of ultra-clean coal powder with low ash content. In this paper, by using an orthogonal design of Taguchi plan, the effects of the physical parameters of different coals, the size of grinding medium and the specific load of pulverized coal on the ultra-fine grinding process are investigated by using a 1. 5 L vertical stirred ball mill in the laboratory. A mechanistic approach based model, matrix population balance model( M-PBM), is proposed to predict the particle size distribution of the ultra-fine grinding products by the stirred ball mill, and by combining the Rosin-Rammler particle size distribution model, the particle size corresponding to any cumulative content under sieve can be accurately predicted. By range analysis, the influences of coal ash content, the size of grinding medium and the specific load of pulverized coal on the energy consumption and specific flux of ultra-fine grinding are discussed. Based on the analysis of coal-ash dissociation process in the ultra-fine grinding of pulverized coal and by combining Tomoyoshi’s energy consumption formula relating specific surface area of particles, the relationship between coal ash content and energy consumption is discussed, and the formulas relating coal ash content, grinding medium size, the specific load of pulverized coal with specific grinding flux and with energy consumption are further established. It is found that the particle size reduction during the ultra-fine wet grinding process of stirring ball mill conforms to the first-order linear kinetic hypothesis. Under a fixed rotating speed of agitating shaft and within the considered particle size reduction range, the ash content of coal has the greatest influence on the specific flux and energy consumption of the stirring ball mill. Within the ultrafine grinding size range which is below 10 μm( p50), the established formulas of specific flux and energy consumption show that the increase in ash content, decrease in grinding medium size( 0. 3-1. 8 mm) and increase in the specific load of pulverized coal will lead to the decrease in energy consumption and increase in specific flux, respectively. [ABSTRACT FROM AUTHOR]

Objective To investigate the effect of f fine nursing management for patients undergoing simultaneous bilateral lobectomy. Methods Totally 52 patients under simultaneous bilateral lobectomy were randomly divided into the control group and observation group, with 26 cases in each group. The control group received routine nursing interventions during perioperative period. The observation group was given fine nursing management. The indwelling time of catheter, length of postoperative hospital stay, hospitalization costs and postoperative complications were recorded. Results The indwelling time of drainage tube and length of postoperative hospital stay in the observation group were shorter than those in the control group(P＜0. 05). There was a case of pneumothorax, 1 case of stage I pressure injury, 5 cases of arrhythmia, 2 cases of breathing difficulties and 2 cases of incision infection in the observation group. There was a case of pneumothorax, 3 cases of stage I pressure injury, 5 cases of arrhythmia, 1 case of breathing difficulties, 5 cases of incision infection and 1 case of death in the control group. Conclusion Implementation of fine nursing management is effective to shorten indwelling time of drainage tube and length of postoperative hospital stay of patients undergoing simultaneous bilateral lobectomy. (目的 探讨同期双侧肺叶切除围手术期实施精细化护理干预的效果。方法 选取2015年1月—2021年12月医院收治的行同期双侧肺叶切除患者52例, 随机分为对照组和观察组, 各26例。对照组围手术期采取常规护理, 观察组围术期采取精细化护理干预。记录和分析两组患者引流管留置时间、术后平均住院日、住院费用和术后并发症。结果 观察组患者引流管留置时间、术后平均住院日较对照组缩短, 差异有统计学意义(P＜0. 05)。观察组术后发生气胸1例, I期压疮1例, 心律失常5例, 呼吸困难2例, 切口感染2例; 对照组术后气胸1例, I期压疮3例, 心律失常5例, 呼吸困难1例, 切口感染5例, 死亡1例。结论 同期双侧肺叶切除围手术期实施精细化护理干预, 能缩短患者引流管留置时间和术后平均住院日, 对促进患者术后康复具有积极意义。)

Objective To investigate the effect of hierarchical nursing based on fall risk assessment for prevention of falls in elderly patients with Parkinson's disease (PD). Methods Totally 200 PD patients were randomly divided into the control group and observation group, with 100 cases in each group. The control group received routine fall prevention and management, while the observation group received hierarchical nursing based on fall risk assessment. The self-made Knowledge-Attitude-Practice (KAP) questionnaire was used to assess the patients’ fall prevention awareness. The Client Satisfaction Questionnaire(CSQ) was used to assess patients’ satisfaction with nursing service. The incidence of falls in a one-year follow-up was observed. Results Total score of KAP and dimension scores of knowledge, attitude and practice were increased in both two groups after interventions, and total score of KAP in the observation group was higher than that in the control group (P＜0. 01). The overall satisfaction rate of the observation group was higher than that of the control group (P＜0. 05). The incidence of falls of the observation group was lower than that of the control group after a one-year follow-up (P＜0. 05). Conclusion The hierarchical nursing based on fall risk assessment for prevention of falls is effective to enhance the knowledge, attitude and practice skills of PD patients, improve the quality of falls prevention and management, and reduce the incidence of falls. (目的 探讨基于跌倒风险评估的分层护理干预对老年帕金森病(PD)患者知信行水平的影响及预防跌倒的效果。方法 选取医院神经内科2018年3月—2020年3月收治的200例老年PD患者作研究对象, 随机分成对照组和观察组, 各100例。对照组实施常规预防跌倒护理干预, 观察组在对照组基础上实施基于跌倒风险评估的分层护理干预。运用自制知信行量表(KAP)问卷评估患者知信行水平, 运用顾客满意度量表(CSQ)评价患者对护理服务的满意度, 记录随访1年期间跌倒发生情况。结果 实施护理干预后, 两组知识、信念、行为维度得分和KAP问卷总分均较干预前提高, 且观察组知识、信念、行为维度得分和KAP问卷总分高于对照组, 差异有统计学意义(P＜0. 01)。观察组总满意度高于对照组(P＜0. 05)。随访1年时观察组总跌倒发生率低于对照组(P＜0. 01)。结论 基于跌倒风险评估的分层护理干预能提升PD患者的护理效果, 提高患者知信行水平, 降低跌倒发生率。)

Based on the characteristics of spraying inspiration and stirring inspiration,a novel jet-stirring coupling flotation device was designed.In order to study its inspiration method,its air-suction mechanism was analyzed theoretically,and also the experimental investigation of the device on the relationship between coupling inspiratory capacity and jet flow and the relationship between stirring inspiratory capacity and impeller rotational speed was conducted by controlling the input frequency of circulating pump motor to adjust jet flow and control liquid level.The results show that the stirring inspiratory capacity increases in a quadratic function with the increase of impeller rotational speed,and the coupling inspiratory capacity increases in an approximate linear with the increase of jet flow;influenced by impeller rotation and liquid level,the coupling inspiratory region and stirring inspiratory region inhale air together under a shallow level (hy≤140 mm),and the coupling inspiratory region inhales air while the stirring inspiratory capacity is low or even zero under deep level (hy>140 mm);and the coupling inspiratory capacity increases first and then decreases with liquid level goes up at low jet flow (motor frequency is less than 35 Hz),and increases with the increase of liquid level at high jet flow (motor frequency is more than 30 Hz);however,the stirring inspiration capacity is sharply reduced with liquid level rising.The maximum total inspiratory capacity is about 4.03 L/min in the deepest liquid level 230 mm and the maximum frequency 50 Hz,and basically satisfies the requirement of air-suction for flotation.The study of air-suction mechanism provides a fundamental basis for a further separation study of the device. [ABSTRACT FROM AUTHOR]