1. Effect of vitamin D on clinical outcomes in patients with thermal injury.
- Author
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Pirdastan, Sepide, Mahdavi Roshan, Marjan, Mobayen, Mohammadreza, Asadzadegan, Reza, Ebrahim Ghafari, Mohammad, Mazhari, Seyed Amirhossein, Sadeghi, Mahsa, Bagheri Toolaroud, Parissa, and Alizadeh Otaghvar, Hamidreza
- Subjects
LENGTH of stay in hospitals ,STATISTICS ,BURNS & scalds ,MANN Whitney U Test ,FISHER exact test ,VITAMIN D ,INFECTION ,DESCRIPTIVE statistics ,CHI-squared test ,VITAMIN D deficiency ,LOGISTIC regression analysis ,DATA analysis software ,LONGITUDINAL method ,DISEASE complications - Abstract
Evaluating complications and mortality risks in burn patients is crucial for effective treatment planning and improving survival rates. This study investigated the relationship between the serum vitamin D level and the clinical outcomes of adult burns patients. This was a prospective cohort of adult patients hospitalized due to thermal burns at a burn centre in the north of Iran. Based on the level of 25 hydroxyvitamin D measured upon admission, patients were divided into two groups of patients with sufficient 25 hydroxyvitamin D level and insufficient 25 hydroxyvitamin D level. Descriptive statistics were used for baseline demographics. Univariate analysis was conducted using Mann–Whitney U, Chi‐square, independent samples, and Fisher's exact tests. A multivariate logistic regression was performed to adjust for the effects of confounding variables. Statistical analyses were conducted using SPSS 28.0 software. A total of 220 patients were included in the study. The average total body surface area burned was 30.52 ± 9.34. Patients with insufficient vitamin D levels had longer hospital stays (12.53 vs. 11.45) and longer stays in the intensive care unit (ICU) (3.32 vs. 2.40) than those with appropriate vitamin D levels. Participants with insufficient vitamin D levels exhibited a numerically higher incidence of infections than those with adequate levels (p < 0.05). The multivariate regression found that vitamin D deficiency levels were associated with increased infection rates and prolonged hospital stay. This study suggests that vitamin D deficiency is a significant risk factor for adverse clinical outcomes in burn patients. Further research is needed to confirm these associations and to explore potential interventions to optimize vitamin D status in this patient population. [ABSTRACT FROM AUTHOR]
- Published
- 2024
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