1,394 results
Search Results
2. The structural heart disease interventional imager rationale, skills and training: a position paper of the European Association of Cardiovascular Imaging
- Author
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Francesco Faletra, Eustachio Agricola, Hani Mahmoud-Elsayed, Nina Ajmone Marsan, Ralph Stephan von Bardeleben, Marc R. Dweck, Erwan Donal, Mark J. Monaghan, Thor Edvardsen, Francesco Ancona, Bogdan A. Popescu, Pal Maurovich-Hovart, José Luis Zamorano, Nina Wunderlich, Martin J. Swaans, Bernard Cosyns, Patrizio Lancellotti, Leyla Elif Sade, José M. C. Ribeiro, Eric Brochet, Agricola, Eustachio, Ancona, Francesco, Brochet, Eric, Donal, Erwan, Dweck, Marc, Faletra, Francesco, Lancellotti, Patrizio, Mahmoud-Elsayed, Hani, Marsan, Nina Ajmone, Maurovich-Hovart, Pal, Monaghan, Mark, Ribeiro, José, Sade, Leyla Elif, Swaans, Martin, Von Bardeleben, Ralph Stephan, Wunderlich, Nina, Zamorano, Jose-Lui, Popescu, Bogdan A, Cosyns, Bernard, Edvardsen, Thor, Istituti di Ricovero e Cura a Carattere Scientifico (IRCCS), Ospedale San Raffaele, AP-HP - Hôpital Bichat - Claude Bernard [Paris], Assistance publique - Hôpitaux de Paris (AP-HP) (AP-HP), Laboratoire Traitement du Signal et de l'Image (LTSI), Université de Rennes 1 (UR1), Université de Rennes (UNIV-RENNES)-Université de Rennes (UNIV-RENNES)-Institut National de la Santé et de la Recherche Médicale (INSERM), CHU Pontchaillou [Rennes], University of Edinburgh, Cardiocentro Ticino [Lugano], Universität Zürich [Zürich] = University of Zurich (UZH), Università degli studi di Bari Aldo Moro (UNIBA), Leiden University Medical Center (LUMC), Semmelweis University of Medicine [Budapest], King‘s College London, Başkent University Hospital [Adana, Turkey], St. Antonius Hospital [Nieuwegein], University Medical Center [Mainz], Hospital Universitario Ramón y Cajal [Madrid], Universidad de Alcalá - University of Alcalá (UAH), Université de Médecine Carol Davila, Universitair Ziekenhus Brussel (UZ Brussel), Oslo University Hospital [Oslo], Université de Rennes (UR)-Institut National de la Santé et de la Recherche Médicale (INSERM), Università degli studi di Bari Aldo Moro = University of Bari Aldo Moro (UNIBA), Universitair Ziekenhuis Brussel = University Hospital of Brussels (UZ Brussel), Jonchère, Laurent, Clinical sciences, Cardio-vascular diseases, Cardiology, and Universiteit Leiden
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medicine.medical_specialty ,Cardiac Catheterization ,Certification ,Heart Diseases ,education ,Psychological intervention ,Context (language use) ,030204 cardiovascular system & hematology ,Subspecialty ,Interventional imaging ,Multimodality ,03 medical and health sciences ,0302 clinical medicine ,medicine ,Medical imaging ,Humans ,Radiology, Nuclear Medicine and imaging ,Medical physics ,030212 general & internal medicine ,Structural heart disease ,Cardiac imaging ,[SDV.IB] Life Sciences [q-bio]/Bioengineering ,business.industry ,General Medicine ,Percutaneous treatment of structural heart disease ,3. Good health ,Cardiac Imaging Techniques ,Position paper ,[SDV.IB]Life Sciences [q-bio]/Bioengineering ,Cardiology and Cardiovascular Medicine ,business - Abstract
Percutaneous therapeutic options for an increasing variety of structural heart diseases (SHD) have grown dramatically. Within this context of continuous expansion of devices and procedures, there has been increased demand for physicians with specific knowledge, skills, and advanced training in multimodality cardiac imaging. As a consequence, a new subspecialty of ‘Interventional Imaging’ for SHD interventions and a new dedicated professional figure, the ‘Interventional Imager’ with specific competencies has emerged. The interventional imager is an integral part of the heart team and plays a central role in decision-making throughout the patient pathway, including the appropriateness and feasibility of a procedure, pre-procedural planning, intra-procedural guidance, and post-procedural follow-up. However, inherent challenges exist to develop a training programme for SHD imaging that differs from traditional cardiovascular imaging pathways. The purpose of this document is to provide the standard requirements for the training in SHD imaging, as well as a starting point for an official certification process for SHD interventional imager.
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- 2021
3. Appropriate use criteria for cardiovascular MRI: SIC - SIRM position paper Part 2 (myocarditis, pericardial disease, cardiomyopathies and valvular heart disease)
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Gianluca Pontone, Cesare Mantini, Aurelio Secinaro, Marco Francone, Mark G. Rabbat, Gesualdo Polizzi, Luigi Natale, Antonio Esposito, Chiara Lanzillo, Viviana Maestrini, Andrea Barison, Francesco Secchi, Marta Focardi, Ciro Indolfi, Giuseppe Mercuro, Giovanni Donato Aquaro, Ernesto Di Cesare, Luigi Lovato, Manuel De Lazzari, Francesco De Cobelli, Silvia Castelletti, Paolo Renzi, Francone, M., Aquaro, G. D., Barison, A., Castelletti, S., de Cobelli, F., de Lazzari, M., Esposito, A., Focardi, M., di Renzi, P., Indolfi, C., Lanzillo, C., Lovato, L., Maestrini, V., Mercuro, G., Natale, L., Mantini, C., Polizzi, G., Rabbat, M., Secchi, F., Secinaro, A., di Cesare, E., and Pontone, G.
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medicine.medical_specialty ,Myocarditis ,Cardiac magnetic resonance ,Cardiology ,Heart Valve Diseases ,Magnetic Resonance Imaging, Cine ,Disease ,030204 cardiovascular system & hematology ,Guideline ,Appropriate Use Criteria ,cardiac magnetic resonance ,03 medical and health sciences ,0302 clinical medicine ,Medical ,Medicine ,Humans ,Pericarditis ,030212 general & internal medicine ,Intensive care medicine ,Cardiac imaging ,Societies, Medical ,Pericardial disease ,medicine.diagnostic_test ,business.industry ,valvular heart disease ,Magnetic resonance imaging ,General Medicine ,medicine.disease ,Prognosis ,Magnetic Resonance Imaging ,Quality Improvement ,radiology ,Data Accuracy ,Italy ,Cine ,cardiology ,cardiovascular system ,Radiology ,Cardiomyopathies ,Position paper ,Cardiology and Cardiovascular Medicine ,business ,Societies ,guideline - Abstract
Cardiovascular magnetic resonance (CMR) has emerged as an accurate diagnostic technique for the evaluation of patients with cardiac disease in the majority of clinical settings, thanks to an established additional diagnostic and prognostic value. This document has been developed by a joined group of experts of the Italian Society of Cardiology (SIC) and Italian Society of Radiology (SIRM) to provide a summary about the current state of technology and clinical applications of CMR, to improve the clinical diagnostic pathways and to promote its inclusion in clinical practice. The writing committee consisted of members and experts of both societies in order to develop a more integrated approach in the field of cardiac imaging. This section 2 will cover myocarditis, pericardial disease, cardiomyopathies and valvular heart disease.
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- 2021
4. Imaging the adult with congenital heart disease: a multimodality imaging approach—position paper from the EACVI
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Giovanni, Di Salvo, Owen, Miller, Sonya, Babu Narayan, Wei, Li, Werner, Budts, Emanuela R, Valsangiacomo Buechel, Alessandra, Frigiola, Annemien E, van den Bosch, Beatrice, Bonello, Luc, Mertens, Tarique, Hussain, Victoria, Parish, Gilbert, Habib, Thor, Edvardsen, Tal, Geva, Helmut, Baumgartner, Michael A, Gatzoulis, Bernard, Cosyns, University of Zurich, Di Salvo, Giovanni, British Heart Foundation, Clinical sciences, Cardio-vascular diseases, Cardiology, Microbes évolution phylogénie et infections (MEPHI), Centre National de la Recherche Scientifique (CNRS)-Institut de Recherche pour le Développement (IRD)-Aix Marseille Université (AMU), and Institut de Recherche pour le Développement (IRD)-Aix Marseille Université (AMU)-Centre National de la Recherche Scientifique (CNRS)
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Cardiac & Cardiovascular Systems ,Heart disease ,medicine.medical_treatment ,RIGHT-VENTRICULAR FUNCTION ,SYSTEMIC RIGHT VENTRICLE ,TERM FOLLOW-UP ,030204 cardiovascular system & hematology ,Diagnostic tools ,Multimodal Imaging ,030218 nuclear medicine & medical imaging ,Congenital ,0302 clinical medicine ,[SDV.MHEP.MI]Life Sciences [q-bio]/Human health and pathology/Infectious diseases ,ACHD ,echocardiography ,REPAIRED TETRALOGY ,ARTERIAL SWITCH OPERATION ,AMERICAN SOCIETY ,Cardiac imaging ,Heart Defects ,Cardiac catheterization ,education.field_of_study ,Radiology, Nuclear Medicine & Medical Imaging ,General Medicine ,3. Good health ,cardiac computed tomography ,cardiovascular magnetic resonance imaging ,multimodality imaging ,Adult ,Heart Defects, Congenital ,Humans ,CARDIOVASCULAR MAGNETIC-RESONANCE ,Cardiology and Cardiovascular Medicine ,Multimodal Imaging/methods ,Life Sciences & Biomedicine ,FUNCTIONAL SINGLE VENTRICLE ,medicine.medical_specialty ,Population ,610 Medicine & health ,2705 Cardiology and Cardiovascular Medicine ,Multimodality ,03 medical and health sciences ,medicine ,Medical imaging ,2741 Radiology, Nuclear Medicine and Imaging ,Radiology, Nuclear Medicine and imaging ,10220 Clinic for Surgery ,Intensive care medicine ,education ,Science & Technology ,Heart Defects, Congenital/diagnostic imaging ,PULMONARY VALVE-REPLACEMENT ,business.industry ,2016–2018 EACVI Scientific Documents Committee ,medicine.disease ,WAVE DOPPLER-ECHOCARDIOGRAPHY ,10036 Medical Clinic ,Cardiovascular System & Cardiology ,Position paper ,business - Abstract
International audience; Advances in the diagnosis and management of congenital heart disease have led to a marked improvement in the survival of adult with congenital heart disease (ACHD) patients. However, ACHD patients are a heterogeneous population, with a large spectrum of anatomic substrates even within specific lesions. In addition, the nature of previous surgery and other intervention is highly variable rendering each patient unique and residual anatomic and haemodynamic abnormalities are very common. As the ACHD population continues to age, acquired heart disease will also require cardiac imaging assessment. It is increasingly recognized in ACHD community that the diagnostic utility of a multimodality cardiovascular approach is greater than the sum of individual tests. In ACHD patients, diagnostic information can be obtained using a variety of diagnostic tools. The aims of this document are to describe the role of each diagnostic modality in the care of ACHD patients and to provide guidelines for a multimodality approach. The goal should be to provide the most appropriate and cost-effective diagnostic pathway for each individual ACHD patient.
- Published
- 2018
5. The Current State and Path Forward For Enterprise Image Viewing: HIMSS-SIIM Collaborative White Paper
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Christopher J. Roth, Louis M. Lannum, Alexander J. Towbin, and Donald K. Dennison
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Diagnostic Imaging ,Imaging informatics ,genetic structures ,Computer science ,education ,Specialty ,ComputingMethodologies_IMAGEPROCESSINGANDCOMPUTERVISION ,Image viewer ,Image display ,computer.software_genre ,Image distribution ,Enterprise imaging ,030218 nuclear medicine & medical imaging ,Management Information Systems ,03 medical and health sciences ,0302 clinical medicine ,White paper ,Digital imaging and communications in medicine (DICOM) ,Integrating healthcare enterprise (IHE) ,Electronic Health Records ,Humans ,Radiology, Nuclear Medicine and imaging ,Use case ,Implementation ,PACS ,Medicine(all) ,Review Paper ,Cardiology PACS ,Radiological and Ultrasound Technology ,Multimedia ,Clinical image viewing ,Interpretation (philosophy) ,Electronic medical record (EMR) ,Enterprise PACS ,Computer Science Applications ,Management information systems ,Radiology Information Systems ,030220 oncology & carcinogenesis ,computer ,Cardiac imaging ,PATH (variable) ,Forecasting - Abstract
Clinical specialties have widely varied needs for diagnostic image interpretation, and clinical image and video image consumption. Enterprise viewers are being deployed as part of electronic health record implementations to present the broad spectrum of clinical imaging and multimedia content created in routine medical practice today. This white paper will describe the enterprise viewer use cases, drivers of recent growth, technical considerations, functionality differences between enterprise and specialty viewers, and likely future states. This white paper is aimed at CMIOs and CIOs interested in optimizing the image-enablement of their electronic health record or those who may be struggling with the many clinical image viewers their enterprises may employ today.
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- 2016
6. Research in cardiac radiology: a European Society of Radiology white paper
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ESR Executive Council 2009 and ESR Working Group on Cardiac Imaging Research of the European Society of Cardiac Radiology
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- 2010
- Full Text
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7. Reporting nuclear cardiology: a joint position paper by the European Association of Nuclear Medicine (EANM) and the European Association of Cardiovascular Imaging (EACVI)
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Erwan Donal, Marcus Hacker, Denis Agostini, Philipp A. Kaufmann, Lars Edenbrandt, Riemert Slart, Albert Flotats, Alessia Gimelli, Juhani Knuuti, Elin Trägårdh, Patrizio Lancellotti, Oliver Lindner, Koen Nieman, Christopher Übleis, Victoria Delgado, Gilbert Habib, Maurizio Galderisi, Hein J. Verberne, Thor Edvardsen, Birger Hesse, Anastasia Kitsiou, Raphael Rosenhek, Vascular Ageing Programme (VAP), Cardiovascular Centre (CVC), Translational Immunology Groningen (TRIGR), Basic and Translational Research and Imaging Methodology Development in Groningen (BRIDGE), Trägårdh, E, Hesse, B, Knuuti, J, Flotats, A, Kaufmann, P. A., Kitsiou, A, Hacker, M, Verberne, H. J., Edenbrandt, L, Delgado, V, Donal, E, Edvardsen, T, Galderisi, Maurizio, Habib, G, Lancellotti, P, Nieman, K, Rosenhek, R, Agostini, D, Gimelli, A, Lindner, O, Slart, R, Ubleis, C., Amsterdam Cardiovascular Sciences, and Nuclear Medicine
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Male ,Practice guideline ,medicine.medical_specialty ,Patient demographics ,Single-photon emission computed tomography ,Sensitivity and Specificity ,Terminology ,Internal medicine ,medicine ,Medical imaging ,Humans ,Radiology, Nuclear Medicine and imaging ,Medical physics ,Radionuclide Imaging ,Image display ,Societies, Medical ,Cardiac imaging ,Nuclear medicine report ,Tomography, Emission-Computed, Single-Photon ,Cardiac Imaging Technique ,medicine.diagnostic_test ,business.industry ,Medicine (all) ,Nuclear cardiology ,General Medicine ,Europe ,Cardiac Imaging Techniques ,Positron emission tomography ,Positron-Emission Tomography ,Practice Guidelines as Topic ,Cardiology ,Position paper ,Female ,Nuclear Medicine ,Cardiology and Cardiovascular Medicine ,Nuclear medicine ,business ,Human - Abstract
The report of an imaging procedure is a critical component of an examination, being the final and often the only communication from the interpreting physician to the referring or treating physician. Very limited evidence and few recommendations or guidelines on reporting imaging studies are available; therefore, an European position statement on how to report nuclear cardiology might be useful. The current paper combines the limited existing evidence with expert consensus, previously published recommendations as well as current clinical practices. For all the applications discussed in this paper (myocardial perfusion, viability, innervation, and function as acquired by single photon emission computed tomography and positron emission tomography or hybrid imaging), headings cover laboratory and patient demographics, clinical indication, tracer administration and image acquisition, findings, and conclusion of the report. The statement also discusses recommended terminology in nuclear cardiology, image display, and preliminary reports. It is hoped that this statement may lead to more attention to create well-written and standardized nuclear cardiology reports and eventually lead to improved clinical outcome.
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- 2015
8. Cardiovascular imaging 2020 in the international journal of cardiovascular imaging: the 10 most downloaded papers in the year 2020
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Arthur E. Stillman and Johan H. C. Reiber
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Editor’s Note ,medicine.medical_specialty ,business.industry ,Bibliometrics ,Cardiovascular Diseases ,Predictive Value of Tests ,Humans ,Medicine ,Radiology, Nuclear Medicine and imaging ,Medical physics ,Cardiology and Cardiovascular Medicine ,business ,Editorial Policies ,Cardiac imaging - Published
- 2021
9. ESC Working Group on Myocardial Function Position Paper: how to study the right ventricle in experimental models
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Haemodynamics ,Functional evaluation ,Right ventricle function ,Experimental myocardial preparations ,Chronic overload ,Cardiac imaging - Abstract
The right ventricle has become an increasing focus in cardiovascular research. In this position paper, we give a brief overview of the specific pathophysiological features of the right ventricle, with particular emphasis on functional and molecular modifications as well as therapeutic strategies in chronic overload, highlighting the differences from the left ventricle. Importantly, we put together recommendations on promising topics of research in the field, experimental study design, and functional evaluation of the right ventricle in experimental models, from non-invasive methodologies to haemodynamic evaluation and ex vivo set-ups.
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- 2014
10. Reporting nuclear cardiology: a joint position paper by the European Association of Nuclear Medicine (EANM) and the European Association of Cardiovascular Imaging (EACVI)
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Tragardh, E, Hesse, B, Knuuti, J, Flotats, A, Kaufmann, PA, Kitsiou, A, Hacker, M, Verberne, HJ, and Edenbrandt, L
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Nuclear cardiology ,Cardiac imaging ,Nuclear medicine reports ,Practice guidelines - Abstract
The report of an imaging procedure is a critical component of an examination, being the final and often the only communication from the interpreting physician to the referring or treating physician. Very limited evidence and few recommendations or guidelines on reporting imaging studies are available; therefore, an European position statement on how to report nuclear cardiology might be useful. The current paper combines the limited existing evidence with expert consensus, previously published recommendations as well as current clinical practices. For all the applications discussed in this paper (myocardial perfusion, viability, innervation, and function as acquired by single photon emission computed tomography and positron emission tomography or hybrid imaging), headings cover laboratory and patient demographics, clinical indication, tracer administration and image acquisition, findings, and conclusion of the report. The statement also discusses recommended terminology in nuclear cardiology, image display, and preliminary reports. It is hoped that this statement may lead to more attention to create well-written and standardized nuclear cardiology reports and eventually lead to improved clinical outcome.
- Published
- 2015
11. The Early Repolarization Pattern: A Consensus Paper.
- Author
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Macfarlane, Peter W., Antzelevitch, Charles, Haissaguerre, Michel, Huikuri, Heikki V., Potse, Mark, Rosso, Raphael, Sacher, Frederic, Tikkanen, Jani T., Wellens, Hein, and Yan, Gan-Xin
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CARDIAC arrest , *ELECTROCARDIOGRAPHY , *CARDIAC imaging , *HEART conduction system , *CARDIAC research , *DIAGNOSIS ,BRUGADA syndrome diagnosis - Abstract
The term early repolarization has been in use for more than 50 years. This electrocardiographic pattern was considered benign until 2008, when it was linked to sudden cardiac arrest due to idiopathic ventricular fibrillation. Much confusion over the definition of early repolarization followed. Thus, the objective of this paper was to prepare an agreed definition to facilitate future research in this area. The different definitions of the early repolarization pattern were reviewed to delineate the electrocardiographic measures to be used when defining this pattern. An agreed definition has been established, which requires the peak of an end-QRS notch and/or the onset of an end-QRS slur as a measure, denoted Jp, to be determined when an interpretation of early repolarization is being considered. One condition for early repolarization to be present is Jp ≥0.1 mV, while ST-segment elevation is not a required criterion. [ABSTRACT FROM AUTHOR]
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- 2015
- Full Text
- View/download PDF
12. ESC Working Group on Myocardial Function Position Paper: how to study the right ventricle in experimental models.
- Author
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Leite‐Moreira, Adelino F., Lourenço, André P., Balligand, Jean‐Luc, Bauersachs, Johann, Clerk, Angela, De Windt, Leon J., Heymans, Stephane, Hilfiker‐Kleiner, Denise, Hirsch, Emilio, Iaccarino, Guido, Kaminski, Karol A., Knöll, Ralph, Mayr, Manuel, Tarone, Guido, Thum, Thomas, and Tocchetti, Carlo G.
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HEART function tests , *RIGHT heart ventricle , *CARDIOVASCULAR diseases , *PATHOLOGICAL physiology , *CARDIAC imaging - Abstract
The right ventricle has become an increasing focus in cardiovascular research. In this position paper, we give a brief overview of the specific pathophysiological features of the right ventricle, with particular emphasis on functional and molecular modifications as well as therapeutic strategies in chronic overload, highlighting the differences from the left ventricle. Importantly, we put together recommendations on promising topics of research in the field, experimental study design, and functional evaluation of the right ventricle in experimental models, from non-invasive methodologies to haemodynamic evaluation and ex vivo set-ups. [ABSTRACT FROM AUTHOR]
- Published
- 2014
- Full Text
- View/download PDF
13. Reporting nuclear cardiology: a joint position paper by the European Association of Nuclear Medicine (EANM) and the European Association of Cardiovascular Imaging (EACVI)
- Author
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Trägårdh, Elin, Hesse, Birger, Knuuti, Juhani, Flotats, Albert, Kaufmann, Philipp A, Kitsiou, Anastasia, Hacker, Marcus, Verberne, Hein J, Edenbrandt, Lars, Delgado, V, Donal, E, Edvardsen, Thor, Galderisi, Maurizio, Habib, Gilbert, Lancellotti, Patrizio, Nieman, K, Rosenhek, R, EACVI, Agostini, D, Gimelli, A, Lindner, Oliver, Slart, Riemer H J A, Übleis, Christopher, EANM, University of Zurich, and Trägårdh, Elin
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2741 Radiology, Nuclear Medicine and Imaging ,610 Medicine & health ,Nuclear cardiology ,142-005 142-005 ,Cardiac imaging ,Nuclear medicine reports ,2705 Cardiology and Cardiovascular Medicine ,Practice guidelines - Published
- 2015
14. Research in cardiac radiology: a European Society of Radiology white paper
- Subjects
Magnetic resonance imaging ,ComputerSystemsOrganization_COMPUTERSYSTEMIMPLEMENTATION ,PET/CT ,Research ,cardiovascular system ,ComputerSystemsOrganization_SPECIAL-PURPOSEANDAPPLICATION-BASEDSYSTEMS ,Statement ,Cardiac imaging ,Computed tomography - Abstract
The past, present and future status of the practice of cardiac imaging is discussed, especially as it relates to cardiac imaging research. Recommendations for the future development are given; these emphasize the importance of multidisciplinary collaboration.
- Published
- 2010
15. Reporting nuclear cardiology: a joint position paper by the European Association of Nuclear Medicine (EANM) and the European Association of Cardiovascular Imaging (EACVI).
- Author
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Trägaårdh, Elin, Hesse, Birger, Knuuti, Juhani, Flotats, Albert, Kaufmann, Philipp A., Kitsiou, Anastasia, Hacker, Marcus, Verberne, Hein J., and Edenbrandt, Lars
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HEART anatomy ,MYOCARDIUM physiology ,ACADEMIC medical centers ,CARDIOLOGY ,CARDIOPULMONARY system ,DEMOGRAPHY ,DEOXY sugars ,DIAGNOSTIC imaging ,EXERCISE tests ,CARDIAC patients ,LEFT heart ventricle ,HEART physiology ,CARDIAC radionuclide imaging ,MEDICAL protocols ,MEDICAL societies ,NUCLEAR medicine ,PHYSICIANS ,RADIOPHARMACEUTICALS ,REPORT writing ,POSITRON emission tomography ,X-ray spectroscopy ,CORONARY angiography - Abstract
The report of an imaging procedure is a critical component of an examination, being the final and often the only communication from the interpreting physician to the referring or treating physician. Very limited evidence and few recommendations or guidelines on reporting imaging studies are available; therefore, an European position statement on how to report nuclear cardiology might be useful. The current paper combines the limited existing evidence with expert consensus, previously published recommendations as well as current clinical practices. For all the applications discussed in this paper (myocardial perfusion, viability, innervation, and function as acquired by single photon emission computed tomography and positron emission tomography or hybrid imaging), headings cover laboratory and patient demographics, clinical indication, tracer administration and image acquisition, findings, and conclusion of the report. The statement also discusses recommended terminology in nuclear cardiology, image display, and preliminary reports. It is hoped that this statement may lead to more attention to create well-written and standardized nuclear cardiology reports and eventually lead to improved clinical outcome. [ABSTRACT FROM AUTHOR]
- Published
- 2015
- Full Text
- View/download PDF
16. The use of weather nowcasting convolutional neural network extrapolators in cardiac PET imaging.
- Author
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Sloka, Scott
- Subjects
CONVOLUTIONAL neural networks ,POSITRON emission tomography ,CARDIAC imaging ,ARTIFICIAL neural networks ,WEATHER forecasting - Abstract
Introduction: Algorithms to predict short‐term changes in local weather modalities have been used in meteorology for many years. These algorithms predict the temporospatial change in the movement of weather patterns such as cloud cover or precipitation. This paper extends convolutional neural network models for weather prediction/nowcasting to predict evolution in the extrapolation of sequentially acquired count data seen with cardiac positron tomography (PET) data to expected value temporally rather than spatially. Methods: Six different algorithms used for nowcasting were modified and applied to confirm the approach. These algorithms were trained on an image data set of both simulated ellipsoids and simulated cardiac PET data. The peak signal‐to‐noise ratio (PSNR) and structural similarity (SSIM) were calculated for each of these trained models. They were compared to the BM3D denoising algorithm as a baseline comparison to a standard method of image denoising. Results: Most of the implemented algorithms showed a significant improvement in both PSNR and SSIM when compared with the baseline standard, especially when the algorithms were implemented in combination. The best results were obtained with a combination of the ConvLSTM and TrajGRU algorithms with a PSNR improvement over the standard of 5 and more than double the SSIM metric. Conclusion: This approach of using serially acquired count data to extrapolate a future expected representation through convolutional neural networks has been shown to produce accurate representations of the expected value when compared with a baseline analytic methodology. This paper confirms that algorithms such as these can be used to substantially improve image estimation and shows significant improvement over a baseline standard. [ABSTRACT FROM AUTHOR]
- Published
- 2023
- Full Text
- View/download PDF
17. Prevalence of left ventricular systolic dysfunction by single echocardiographic view: towards an evidence-based point of care cardiac ultrasound scanning protocol
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Christina Luong, John Jue, Kenneth Gin, Michael Tsang, Shekoofeh Saboktakin Rizi, Darwin F. Yeung, Teresa S.M. Tsang, and Eric C. Sayre
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medicine.medical_specialty ,Original Paper ,Left ventricular dysfunction ,Ejection fraction ,business.industry ,Cardiac Ultrasound ,McNemar's test ,medicine.anatomical_structure ,Single view ,Parasternal line ,Echocardiography ,Internal medicine ,Cardiac ultrasound ,medicine ,Cardiology ,Radiology, Nuclear Medicine and imaging ,Regional wall motion abnormality ,Cardiology and Cardiovascular Medicine ,business ,Papillary muscle ,Cardiac imaging ,Point of care - Abstract
Limited views are often obtained in the setting of cardiac ultrasound, however, the likelihood of missing left ventricular (LV) dysfunction based on a single view is not known. We sought to determine the echo views that were least likely to miss LV systolic dysfunction in consecutive transthoracic echocardiograms (TTEs). Structured data from TTEs performed at 2 hospitals from September 25, 2017, to January 15, 2019, were screened. Studies of interest were those with reported LV dysfunction. Views evaluated were the parasternal long-axis (PLAX), parasternal-short axis at mitral (PSAX M), papillary muscle (PSAX PM), and apical (PSAX A) levels, apical 2 (AP2), apical 3 (AP3), and apical 4 (AP4) chamber views. The probability that a view contained at least 1 abnormal segment was determined and analyzed with McNemar’s test for 21 adjusted pair-wise comparisons. There were 4102 TTE studies included for analysis. TTEs on males comprised 72.7% of studies with a mean LV ejection fraction of 42.8 ± 9.7%. The echo view with the greatest likelihood of encompassing an abnormal segment was the AP2 view with a prevalence of 93.4% (p 82% of the time in the setting of LV systolic dysfunction, with a prevalence of up to 93.4% in the apical windows. Supplementary Information The online version contains supplementary material available at 10.1007/s10554-021-02460-4.
- Published
- 2021
18. Technological Advances in SPECT and SPECT/CT Imaging.
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Bouchareb, Yassine, AlSaadi, Afrah, Zabah, Jawa, Jain, Anjali, Al-Jabri, Aziza, Phiri, Peter, Shi, Jian Qing, Delanerolle, Gayathri, and Sirasanagandla, Srinivasa Rao
- Subjects
COMPUTED tomography ,SEMICONDUCTOR detectors ,AVALANCHE photodiodes ,CARDIAC imaging ,RADIOLOGY - Abstract
Single photon emission tomography/computed tomography (SPECT/CT) is a mature imaging technology with a dynamic role in the diagnosis and monitoring of a wide array of diseases. This paper reviews the technological advances, clinical impact, and future directions of SPECT and SPECT/CT imaging. The focus of this review is on signal amplifier devices, detector materials, camera head and collimator designs, image reconstruction techniques, and quantitative methods. Bulky photomultiplier tubes (PMTs) are being replaced by position-sensitive PMTs (PSPMTs), avalanche photodiodes (APDs), and silicon PMs to achieve higher detection efficiency and improved energy resolution and spatial resolution. Most recently, new SPECT cameras have been designed for cardiac imaging. The new design involves using specialised collimators in conjunction with conventional sodium iodide detectors (NaI(Tl)) or an L-shaped camera head, which utilises semiconductor detector materials such as CdZnTe (CZT: cadmium–zinc–telluride). The clinical benefits of the new design include shorter scanning times, improved image quality, enhanced patient comfort, reduced claustrophobic effects, and decreased overall size, particularly in specialised clinical centres. These noticeable improvements are also attributed to the implementation of resolution-recovery iterative reconstructions. Immense efforts have been made to establish SPECT and SPECT/CT imaging as quantitative tools by incorporating camera-specific modelling. Moreover, this review includes clinical examples in oncology, neurology, cardiology, musculoskeletal, and infection, demonstrating the impact of these advancements on clinical practice in radiology and molecular imaging departments. [ABSTRACT FROM AUTHOR]
- Published
- 2024
- Full Text
- View/download PDF
19. Mechanical concordance between left atrium and left atrial appendage in nonvalvular atrial fibrillation: can it be exploited to avoid transesophageal echocardiography prior to electrical cardioversion during Covid-19 pandemic?
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Gian Luigi Nicolosi, Giuseppe Ambrosio, Andrea Sonaglioni, Gian Franco Gensini, and Michele Lombardo
- Subjects
Male ,medicine.medical_specialty ,Concordance ,Electric Countershock ,Predictive Value of Tests ,Statistical significance ,Internal medicine ,Atrial Fibrillation ,Left atrial appendage thrombosis ,Humans ,Medicine ,Atrial Appendage ,Radiology, Nuclear Medicine and imaging ,Heart Atria ,Transesophageal echocardiography ,Pandemics ,Cardiac imaging ,Retrospective Studies ,Original Paper ,Framingham Risk Score ,Ejection fraction ,SARS-CoV-2 ,business.industry ,COVID-19 ,Atrial fibrillation ,Gold standard (test) ,medicine.disease ,Thrombosis ,Cardiology ,Nonvalvular atrial fibrillation ,Female ,Cardiology and Cardiovascular Medicine ,business ,Echocardiography, Transesophageal ,Left atrial myocardial strain analysis - Abstract
Transesophageal echocardiography (TEE) is the gold standard for assessing left atrial appendage (LAA) mechanic and thrombosis (LAAT); however, TEE is a high-risk procedure for viral transmission during coronavirus disease 2019 (COVID-19) pandemic. We investigated whether deformation indices of left atrium (LA) at transthoracic echocardiography (TTE) correlate with those of LAA assessed by TEE in nonvalvular atrial fibrillation (NVAF) patients undergoing electrical cardioversion (ECV). Consecutive patients with NVAF of ≥ 48 h or unknown duration, who underwent TEE and TTE at our Institution before ECV were retrospectively investigated. Standard echo-Doppler and LA and LAA myocardial strain and strain rate parameters were analyzed. A total of 115 NVAF patients (71.3 ± 8.1 yr/o, 59.1% men) were included: LAAT was diagnosed in 25 (21.7%) patients. Compared to patients without LAAT, those with LAAT had significantly higher CHA2DS2-VASc Risk score (4.5 ± 1.4 vs. 3.5 ± 1.1, p
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- 2021
20. Clinical and cardiac magnetic resonance findings in post-COVID patients referred for suspected myocarditis
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Marco Schmidt, Edelgard Lindhoff-Last, Rajendra H. Mehta, Philipp Breitbart, Axel Schmermund, Alexander Koch, Annett Magedanz, Holger Eggebrecht, and Thomas Voigtländer
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Adult ,Male ,medicine.medical_specialty ,Myocarditis ,Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) ,Disease ,Chest pain ,Ventricular Function, Left ,Electrocardiography ,Fibrosis ,Internal medicine ,medicine ,Humans ,Cardiac imaging ,Original Paper ,Ejection fraction ,business.industry ,MR-tomography ,COVID-19 ,Heart ,Stroke Volume ,General Medicine ,Middle Aged ,medicine.disease ,Magnetic Resonance Imaging ,Myocardial inflammation ,Echocardiography ,Cardiology ,Female ,medicine.symptom ,Cardiology and Cardiovascular Medicine ,business ,Cardiac magnetic resonance - Abstract
Objectives We assessed possible myocardial involvement in previously cardiac healthy post-COVID patients referred for persisting symptoms with suspected myocarditis. Background Prior studies suggested myocardial inflammation in patients with coronavirus-induced disease 2019 (COVID-19). However, the prevalence of cardiac involvement among COVID patients varied between 1.4 and 78%. Methods A total of 56 post-COVID patients without previous heart diseases were included consecutively into this study. All patients had positive antibody titers against SARS-CoV-2. Patients were referred for persistent symptoms such as chest pain/discomfort, shortness of breath, or intolerance to activity. All patients underwent standardized cardiac assessment including electrocardiogram (ECG), cardiac biomarkers, echocardiography, and cardiac magnetic resonance (CMR). Results 56 Patients (46 ± 12 years, 54% females) presented 71 ± 66 days after their COVID-19 disease. In most patients, the course of COVID-19 was mild, with hospital treatment being necessary in five (9%). At presentation, patients most often reported persistent fatigue (75%), chest pain (71%), and shortness of breath (66%). Acute myocarditis was confirmed by T1/T2-weighed CMR and elevated NTpro-BNP levels in a single patient (2%). Left ventricular ejection fraction was 56% in this patient. Additional eight patients (14%) showed suspicious CMR findings, including myocardial edema without fibrosis (n = 3), or non-ischemic myocardial injury suggesting previous inflammation (n = 5). However, myocarditis could ultimately not be confirmed according to 2018 Lake Louise criteria; ECG, echo and lab findings were inconspicuous in all eight patients. Conclusions Among 56 post-COVID patients with persistent thoracic complaints final diagnosis of myocarditis could be confirmed in a single patient using CMR. Graphic abstract
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- 2021
21. Comparing downstream consequences of normal exercise stress echocardiograms and cardiac computed tomography angiography scans in patients suspected of having of obstructive coronary artery disease: a retrospective cohort study of Tricare beneficiaries
- Author
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Brandon L Walker, Kevin A Loudermilk, Samuel J Farrell, Andrew C Wyatt, Chu-Chiao Chu, Andrea N Keithler, Dustin M. Thomas, Susan G Williams, Jessica Rouse, Rosco S Gore, Cory G. Madigan, Michael B Adams, Laith R Dinkha, and Robert T Hoard
- Subjects
medicine.medical_specialty ,Computed Tomography Angiography ,Coronary Artery Disease ,Coronary Angiography ,Medicare ,Coronary artery disease ,Predictive Value of Tests ,Cardiac computed tomography angiography ,Internal medicine ,Cardiac CT ,Stress Echocardiography ,medicine ,Humans ,Fee Schedule ,Downstream testing ,Radiology, Nuclear Medicine and imaging ,In patient ,Cardiac imaging ,Aged ,Retrospective Studies ,Original Paper ,business.industry ,Exercise stress ,Retrospective cohort study ,medicine.disease ,United States ,Stress echocardiography ,Cardiology ,Cardiology and Cardiovascular Medicine ,business - Abstract
To compare overall number of downstream tests and total costs between negative exercise stress echocardiograms (ESE) or cardiac computed tomography angiography scans (CCTA) in symptomatic Tricare beneficiaries suspected of having coronary artery disease (CAD). This is a retrospective cohort study examining 651 propensity-matched patients who underwent ESE or CCTA with normal results between 2008 and 2014 at the United States’ largest Department of Defense hospital. The total number of additional downstream tests over the next five years was determined. The total costs associated with each arm, inclusive of the initial test and all subsequent tests, were calculated using the 2018 Medicare Physician Fee Schedule. 18.5 percent of patients with a normal ESE result underwent some additional form of cardiac testing over the five years after initial testing compared to 12.8 percent of patients with a normal CCTA. The absolute difference in total number of downstream tests between both study groups was 5.7 percent (p = 0.03). When factoring the costs of the initial test as well as the downstream tests, the ESE group was associated with overall lower costs compared to the CCTA group, 351 United States Dollars (USD) versus 496 USD (p
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- 2021
22. Echocardiography and EuroSCORE II for the stratification of low-gradient severe aortic stenosis and preserved left ventricular ejection fraction
- Author
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Brandon Stacey, Sanjay Gandhi, Neal D. Kon, Min Pu, Yan Fan, Robert J. Applegate, Edward H. Kincaid, David Zhao, and Hong Shen
- Subjects
Aortic valve ,medicine.medical_specialty ,Ventricular Function, Left ,Euroscore ii ,Predictive Value of Tests ,Internal medicine ,medicine ,Humans ,Radiology, Nuclear Medicine and imaging ,Cardiac imaging ,Original Paper ,Aortic valve intervention ,Ejection fraction ,business.industry ,Aortic stenosis ,EuroSCORE ,Stroke Volume ,Stroke volume ,Aortic Valve Stenosis ,EuroSCORE II ,medicine.disease ,Stenosis ,medicine.anatomical_structure ,Echocardiography ,Heart failure ,Cardiology ,Cardiology and Cardiovascular Medicine ,business - Abstract
The purpose of this study was to explore the utility of echocardiography and the EuroSCORE II in stratifying patients with low-gradient severe aortic stenosis (LG SAS) and preserved left ventricular ejection fraction (LVEF ≥ 50%) with or without aortic valve intervention (AVI). The study included 323 patients with LG SAS (aortic valve area ≤ 1.0 cm2 and mean pressure gradient
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- 2021
23. Left ventricular global longitudinal strain in low cardiac risk outpatients who recently recovered from coronavirus disease 2019
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Ali Rıza Akyüz, Selim Kul, Ahmet Özderya, Ali Hakan Konuş, Muhammet Rasit Sayin, Sinan Şahin, Ezgi Kalaycıoğlu, and Turhan Turan
- Subjects
Adult ,medicine.medical_specialty ,Low cardiac risk ,Longitudinal strain ,Coronavirus disease 2019 (COVID-19) ,SARS coronavirus ,Population ,Ventricular global longitudinal strain ,Logistic regression ,Asymptomatic ,Ventricular Function, Left ,Ventricular Dysfunction, Left ,Predictive Value of Tests ,Internal medicine ,Outpatients ,medicine ,Humans ,Radiology, Nuclear Medicine and imaging ,education ,Home quarantine ,Cardiac imaging ,Subclinical infection ,education.field_of_study ,Original Paper ,business.industry ,SARS-CoV-2 ,COVID-19 ,Stroke Volume ,Odds ratio ,Cardiology ,medicine.symptom ,Cardiology and Cardiovascular Medicine ,business - Abstract
The cardiac sequelae of coronavirus disease 2019 (COVID-19), a worldwide global pandemic, are still uncertain, particularly in the asymptomatic, low cardiac risk outpatient population. This study aims to evaluate the asymptomatic, low cardiac risk out-patient population who recently recovered from COVID-19, using 2-D left ventricular-global longitudinal strain (LV-GLS) proven to be capable of detecting subclinical myocardial injury. Out of 305 COVID-19 positive patients, 70 asymptomatic out-patients were determined as the study group and 70 age and sex-matched healthy adults as the control group. The echocardiographic examination was performed with the Philips IE33 system, and LV-GLS was measured using commercially available software QLAB 9 (cardiac motion quantification; Philips Medical Systems). The absolute value of LV-GLS ≤ 18 did deem to be impaired LV-GLS. The absolute value of LV-GLS was statistically significantly lower in the COVID-19 group than in healthy controls (19.17 ± 2.65 vs. 20.07 ± 2.19, p = 0.03). The correlation between having recovered from COVID-19 and impaired LV-GLS (≤18) did detect with the Pearson correlation test (p = 0.02). Having recovered from COVID-19 was found as a predictor for detecting impaired LV-GLS (≤18) in the multivariable logistic regression analysis (odds ratio, 0.133 (0.038-0.461); 95% CI, p = 0.001). This study suggests that COVID-19 may cause subclinical LV dysfunction detected by LV-GLS during early recovery even in a population of patients at low cardiac risk, asymptomatic, and recovered with home quarantine. The study findings indicate that the long-term cardiovascular follow-up of these patients may be more important than thought.
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- 2021
24. In vivo assessment of endothelial permeability of coronary lesions with variable degree of stenosis using an albumin-binding MR probe
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Thomas Wurster, Ulf Landmesser, Youssef S. Abdelwahed, Marcus R. Makowski, Carsten Skurk, Andreas Schuster, Michel Noutsias, Leif-Christopher Engel, Boris Bigalke, René M. Botnar, Kevin Gigengack, Bernd Hamm, Alexander Lauten, and Costantia Manes
- Subjects
Endothelial damage ,Contrast Media ,Constriction, Pathologic ,Molecular MRI ,030204 cardiovascular system & hematology ,Coronary Angiography ,Permeability ,030218 nuclear medicine & medical imaging ,Coronary artery disease ,03 medical and health sciences ,0302 clinical medicine ,Predictive Value of Tests ,Albumins ,Humans ,Medicine ,Radiology, Nuclear Medicine and imaging ,Prospective Studies ,Target-specific MR probe ,Cardiac imaging ,Stenosis ,Original Paper ,QCA ,medicine.diagnostic_test ,business.industry ,Coronary Stenosis ,Area under the curve ,Gadofosveset ,Magnetic resonance imaging ,medicine.disease ,Magnetic Resonance Imaging ,ddc ,Angiography ,Biomarker (medicine) ,Cardiology and Cardiovascular Medicine ,business ,Nuclear medicine ,medicine.drug - Abstract
MR imaging with an albumin-binding probe enables the visualization of endothelial permeability and damage in the arterial system. The goal of this study was to compare signal enhancement of lesions with different grades of stenosis segments on molecular CMR in combination with the albumin-binding probe gadofosveset. This prospective clinical study included patients with symptoms suggestive of coronary artery disease (CAD). Patients underwent gadofosveset-enhanced cardiovascular magnetic resonance (CMR) imaging and x-ray angiography (QCA) within 24 h. CMR imaging was performed prior to and 24 h following the administration of gadofosveset. Contrast-to-noise ratios (CNRs) between segments with different grades of stenosis were compared. Overall, n = 203 segments of 26 patients were included. Lesions with more than > 70% stenosis demonstrated significantly higher CNRs compared to lesions p 70% stenosis showed significant higher signal enhancement compared to segments located upstream of these lesions (7.3 ± 8.8 vs. 2.8 ± 2.2; p = 0.02). No difference in signal enhancement between segments proximal and distal of lesions with stenosis greater than 50% was measured (3.3 ± 2.8 vs. 2.4 ± 2.7; p = 0.18). ROC analysis for the detection of lesions ≥ 70% revealed an area under the curve of 0.774 (95% CI 0.681–0.866). This study suggests that relevant coronary stenosis and their down-stream segments are associated with increased signal enhancement on Gadofosveset-enhanced CMR, suggesting a higher endothelial permeability in these lesions. An albumin-binding MR probe could represent a novel in vivo biomarker for the identification and characterization of these vulnerable coronary segments.
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- 2021
25. Discordance in the diagnostic assessment of vulnerable plaques between radiofrequency intravascular ultrasound versus optical coherence tomography among patients with acute myocardial infarction: insights from the IBIS-4 study
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Yasushi Ueki, Giovanni Pedrazzini, Konstantinos C. Koskinas, Masanori Taniwaki, Marco Roffi, Kyohei Yamaji, Lorenz Räber, Tatsuhiko Otsuka, Lene Holmvang, Sylvain Losdat, Maria D. Radu, Jouke Dijkstra, Stephan Windecker, Rafaela Maldonado, Alexios Karagiannis, and Hector M. Garcia-Garcia
- Subjects
genetic structures ,medicine.medical_treatment ,Myocardial Infarction ,Lumen (anatomy) ,610 Medicine & health ,Fibroatheroma ,Coronary Artery Disease ,030204 cardiovascular system & hematology ,Lesion ,03 medical and health sciences ,0302 clinical medicine ,Optical coherence tomography ,Predictive Value of Tests ,Intravascular ultrasound ,Humans ,Medicine ,Radiology, Nuclear Medicine and imaging ,cardiovascular diseases ,030212 general & internal medicine ,Myocardial infarction ,Ultrasonography, Interventional ,Cardiac imaging ,Original Paper ,medicine.diagnostic_test ,business.industry ,Percutaneous coronary intervention ,medicine.disease ,Coronary Vessels ,Plaque, Atherosclerotic ,eye diseases ,Coronary arteries ,medicine.anatomical_structure ,Radiofrequency ,sense organs ,medicine.symptom ,Cardiology and Cardiovascular Medicine ,business ,Nuclear medicine ,Tomography, Optical Coherence - Abstract
We aimed to evaluate the diagnostic agreement between radiofrequency (RF) intravascular ultrasound (IVUS) and optical coherence tomography (OCT) for thin-cap fibroatheroma (TCFA) in non-infarct-related coronary arteries (non-IRA) in patients with ST-segment elevation myocardial infarction (STEMI). In the Integrated Biomarker Imaging Study (IBIS-4), 103 STEMI patients underwent OCT and RF-IVUS imaging of non-IRA after successful primary percutaneous coronary intervention and at 13-month follow-up. A coronary lesion was defined as a segment with ≥ 3 consecutive frames (≈1.2 mm) with plaque burden ≥ 40% as assessed by grayscale IVUS. RF-IVUS-derived TCFA was defined as a lesion with > 10% confluent necrotic core abutting to the lumen in > 10% of the circumference. OCT-TCFA was defined by a minimum cap thickness
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- 2021
26. Echocardiographic assessment of the right ventricle in COVID-19: a systematic review
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Giovanni Pedrazzini, Gregorio Tersalvi, Alessio Gasperetti, Mattia Busana, Dario Winterton, Marco Vicenzi, Luigi Biasco, and Simone Ghidini
- Subjects
medicine.medical_specialty ,Coronavirus disease 2019 (COVID-19) ,Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) ,Heart Ventricles ,Ventricular Dysfunction, Right ,MEDLINE ,Pulmonary hypertension ,Predictive Value of Tests ,Internal medicine ,medicine ,Humans ,Radiology, Nuclear Medicine and imaging ,Cardiac imaging ,Review Paper ,business.industry ,SARS-CoV-2 ,COVID-19 ,medicine.disease ,medicine.anatomical_structure ,Ventricle ,Echocardiography ,Predictive value of tests ,Right heart ,Cardiology ,Right ventricle ,Cardiology and Cardiovascular Medicine ,business - Abstract
Cardiac involvement has been frequently reported in COVID-19 as responsible of increased morbidity and mortality. Given the importance of right heart function in acute and chronic respiratory diseases, its assessment in SARS-CoV-2 infected patients may add prognostic accuracy. Transthoracic echocardiography has been proposed to early predict myocardial injury and risk of death in hospitalized patients. This systematic review presents the up-to-date sum of literature regarding right ventricle ultrasound assessment. We evaluated commonly used echocardiographic parameters to assess RV function and discussed their relationship with pathophysiological mechanisms involved in COVID-19. We searched Medline and Embase for studies that used transthoracic echocardiography for right ventricle assessment in patients with COVID-19.
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- 2021
27. Comparison between myocardial function assessed by echocardiography during hospitalization for COVID-19 and at 4 months follow-up
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B. van den Borst, T M H Eijsvogels, B. M. A. van Bakel, Anthonie L. Duijnhouwer, Robin Nijveldt, A.P.J. van Dijk, F.L. van de Veerdonk, A C Dimitriu-Leen, P C Koopmans, R R J van Kimmenade, J. Vos, Frank H. Bosch, Q. de Mast, and F M A van den Heuvel
- Subjects
Male ,medicine.medical_specialty ,Coronavirus disease 2019 (COVID-19) ,Vascular damage Radboud Institute for Health Sciences [Radboudumc 16] ,lnfectious Diseases and Global Health Radboud Institute for Molecular Life Sciences [Radboudumc 4] ,Subgroup analysis ,030204 cardiovascular system & hematology ,Single Center ,Communicable Diseases ,Healthcare improvement science Radboud Institute for Health Sciences [Radboudumc 18] ,03 medical and health sciences ,0302 clinical medicine ,Predictive Value of Tests ,Internal medicine ,medicine ,Humans ,Radiology, Nuclear Medicine and imaging ,030212 general & internal medicine ,Prospective Studies ,Prospective cohort study ,Cardiac imaging ,Original Paper ,Ejection fraction ,business.industry ,SARS-CoV-2 ,COVID-19 ,Stroke Volume ,Stroke volume ,Middle Aged ,Hospitalization ,lnfectious Diseases and Global Health Radboud Institute for Health Sciences [Radboudumc 4] ,Echocardiography ,Predictive value of tests ,Cardiology ,Myocardial function ,Female ,Cardiology and Cardiovascular Medicine ,business ,Follow-Up Studies - Abstract
Contains fulltext : 244778.pdf (Publisher’s version ) (Open Access) In patients hospitalized for corona virus infectious disease 19 (COVID-19) it is currently unknown whether myocardial function changes after recovery and whether this is related to elevated cardiac biomarkers. In this single center, prospective cohort study we consecutively enrolled hospitalized COVID-19 patients between 1 April and 12 May 2020. All patients underwent transthoracic echocardiography (TTE) evaluation during hospitalization and at a median of 131 days (IQR; 116-136) follow-up. Of the 51 patients included at baseline, 40 (age: 62 years (IQR; 54-68), 78% male) were available for follow-up TTE. At baseline, 68% of the patients had a normal TTE, regarding left ventricular (LV) and right ventricular (RV) volumes and function, compared to 83% at follow-up (p = 0.07). Median LV ejection fraction (60% vs. 58%, p = 0.54) and tricuspid annular plane systolic excursion (23 vs 22 mm, p = 0.18) were comparable between hospitalization and follow-up, but a significantly lower RV diameter (39 vs. 34 mm, p = 0.002) and trend towards better global longitudinal strain (GLS) (- 18.5% vs - 19.1%, p = 0.07) was found at follow-up. Subgroup analysis showed no relation between patients with and without elevated TroponinT and/or NT-proBNP during hospitalization and myocardial function at follow-up. Although there were no significant differences in individual myocardial function parameters at 4 months follow-up compared to hospitalisation for COVID-19, there was an overall trend towards normalization in myocardial function, predominantly due to a higher rate of normal GLS at follow-up. 01 december 2021
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- 2021
28. Regional myocardial function at preclinical disease stage of hypertrophic cardiomyopathy in female gene variant carriers
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Tjeerd Germans, Celine Seegers, Albert C. van Rossum, Pierre Croisille, Patrick Clarysse, Jolanda van der Velden, Rahana Y. Parbhudayal, Cardiology, ACS - Heart failure & arrhythmias, Physiology, Modeling & analysis for medical imaging and Diagnosis (MYRIAD), Centre de Recherche en Acquisition et Traitement de l'Image pour la Santé (CREATIS), Université Jean Monnet [Saint-Étienne] (UJM)-Hospices Civils de Lyon (HCL)-Institut National des Sciences Appliquées de Lyon (INSA Lyon), Institut National des Sciences Appliquées (INSA)-Université de Lyon-Institut National des Sciences Appliquées (INSA)-Université de Lyon-Université Claude Bernard Lyon 1 (UCBL), Université de Lyon-Centre National de la Recherche Scientifique (CNRS)-Institut National de la Santé et de la Recherche Médicale (INSERM)-Université Jean Monnet [Saint-Étienne] (UJM)-Hospices Civils de Lyon (HCL)-Institut National des Sciences Appliquées de Lyon (INSA Lyon), Université de Lyon-Centre National de la Recherche Scientifique (CNRS)-Institut National de la Santé et de la Recherche Médicale (INSERM), and Imagerie et modélisation Vasculaires, Thoraciques et Cérébrales (MOTIVATE)
- Subjects
Male ,Cardiac function curve ,medicine.medical_specialty ,TNNT2 ,[SDV.IB.IMA]Life Sciences [q-bio]/Bioengineering/Imaging ,Diastole ,Magnetic Resonance Imaging, Cine ,030204 cardiovascular system & hematology ,Asymptomatic ,030218 nuclear medicine & medical imaging ,03 medical and health sciences ,MYBPC3 ,MYH7 ,0302 clinical medicine ,Predictive Value of Tests ,Internal medicine ,medicine ,Humans ,Radiology, Nuclear Medicine and imaging ,Cardiac imaging ,Original Paper ,medicine.diagnostic_test ,business.industry ,Myocardium ,Hypertrophic cardiomyopathy ,Heart ,Tissue tagging ,Magnetic resonance imaging ,Cardiomyopathy, Hypertrophic ,medicine.disease ,Cardiology ,Female ,medicine.symptom ,Cardiology and Cardiovascular Medicine ,business ,[SPI.SIGNAL]Engineering Sciences [physics]/Signal and Image processing - Abstract
We recently showed more severe diastolic dysfunction at the time of myectomy in female compared to male patients with obstructive hypertrophic cardiomyopathy. Early recognition of aberrant cardiac contracility using cardiovascular magnetic resonance (CMR) imaging may identify women at risk of cardiac dysfunction. To define myocardial function at an early disease stage, we studied regional cardiac function using CMR imaging with tissue tagging in asymptomatic female gene variant carriers. CMR imaging with tissue tagging was done in 13 MYBPC3, 11 MYH7 and 6 TNNT2 gene carriers and 16 age-matched controls. Regional peak circumferential strain was derived from tissue tagging images of the basal and midventricular segments of the septum and lateral wall. Left ventricular wall thickness and global function were comparable between MYBPC3, MYH7, TNNT2 carriers and controls. MYH7 gene variant carriers showed a different strain pattern as compared to the other groups, with higher septal peak circumferential strain at the basal segments compared to the lateral wall, whereas MYBPC3, TNNT2 carriers and controls showed higher strain at the lateral wall compared to the septum. Only subtle gene-specific changes in strain pattern occur in the myocardium preceding development of cardiac hypertrophy. Overall, our study shows that there are no major contractile deficits in asymptomatic females carrying a pathogenic gene variant, which would justify the use of CMR imaging for earlier diagnosis.
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- 2021
29. Multi-modality assessment and role of left atrial function as an imaging biomarker in cardiovascular disease
- Author
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Anvesha Singh, Prathap Kanagala, Aseel Alfuhied, and Gerry P McCann
- Subjects
Cardiac function curve ,medicine.medical_specialty ,Imaging biomarker ,Cardiac magnetic resonance ,Left atrium ,Magnetic Resonance Imaging, Cine ,Disease ,Multi modality ,Strain ,Left atrial ,Predictive Value of Tests ,Internal medicine ,medicine ,Humans ,Radiology, Nuclear Medicine and imaging ,Heart Atria ,Cardiac imaging ,Review Paper ,business.industry ,Reproducibility of Results ,medicine.anatomical_structure ,Echocardiography ,Cardiovascular Diseases ,cardiovascular system ,Cardiology ,Atrial Function, Left ,Cardiology and Cardiovascular Medicine ,business ,Biomarkers - Abstract
The left atrium (LA) plays a vital role in maintaining normal cardiac function. LA volume and function have been utilised as important imaging biomarkers, with their prognostic value demonstrated in multiple cardiac conditions. More recently, there has been a sharp increase in the number of publications utilising LA strain by echocardiography and cardiac magnetic resonance (CMR) imaging. However, little is known about its prognostic value or reproducibility as a technique. In this review, we aim to highlight the conventional and novel imaging techniques available for LA assessment, using echocardiography and CMR, their role as an imaging biomarker in cardiovascular disease, the reproducibility of the techniques and the current limitations to their clinical application. We identify a need for further standardisation of techniques, with establishment of ‘normal’ cut-offs before routine clinical application can be made. Supplementary Information The online version contains supplementary material available at 10.1007/s10554-021-02316-x.
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- 2021
30. Usefulness of a multiparametric evaluation including global longitudinal strain for an early diagnosis of acute myocarditis
- Author
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Marta Focardi, Maria Concetta Pastore, Matteo Cameli, Anna Degiovanni, Giuseppe Patti, and Enrico Guido Spinoni
- Subjects
Global longitudinal strain ,Adult ,Male ,medicine.medical_specialty ,Myocarditis ,Cardiac magnetic resonance ,Speckle tracking echocardiography ,030204 cardiovascular system & hematology ,Ventricular Function, Left ,030218 nuclear medicine & medical imaging ,03 medical and health sciences ,Young Adult ,0302 clinical medicine ,Cardiac magnetic resonance imaging ,Predictive Value of Tests ,Internal medicine ,White blood cell ,medicine ,Humans ,Radiology, Nuclear Medicine and imaging ,Cardiac imaging ,Speckle tracking ,Retrospective Studies ,Original Paper ,Ejection fraction ,medicine.diagnostic_test ,business.industry ,Middle Aged ,medicine.disease ,Acute myocarditis ,medicine.anatomical_structure ,Early Diagnosis ,Echocardiography ,Cardiology ,Population study ,Cardiology and Cardiovascular Medicine ,business - Abstract
Cardiac magnetic resonance imaging (CMRI) represents the main imaging modality for diagnosing acute myocarditis. However, its limited availability could entail missing or delayed diagnosis. A reduction of left ventricular global longitudinal strain (LV GLS) by speckle tracking echocardiography (STE) correlates with amount of oedema in acute myocarditis and here may be early detected. Aim was to evaluate the diagnostic and prognostic role of 3-layers LV GLS in patients with acute myocarditis. Out of 122 patients with suspected acute myocarditis, a total of 86 consecutive patients with CMRI-confirmed acute myocarditis admitted in two Italian institutions were retrospectively screened. Exclusion criteria were met in 29 patients because of poor acoustic window or missing data. A total of 57 patients were then included. Clinical characteristics, laboratory examinations, transthoracic echocardiography data and STE parameters were collected early after hospitalization. In the study population, mean age was 38.8 ± 15.6 years, the prevalence of male gender was 90%. On admission, 22 patients (39%) had fever (body temperature > 37.5 °), mean white blood cell (WBC) count was 10.9 ± 1.7/10^3 and overall LV ejection fraction was 50.1% ± 11.2. An epicardial LV GLS 10.0/10^3 was able to identify all patients with CMRI-diagnosed acute myocarditis. An epicardial LV GLS
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- 2021
31. Coronary artery calcification and epicardial adipose tissue as independent predictors of mortality in COVID-19
- Author
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Mario J. Garcia, Eitan Novogrodsky, Leandro Slipczuk, Ulrich P. Jorde, Jeffrey M. Levsky, Richard Sekerak, Alison Schonberger, Damini Dey, and Francesco Castagna
- Subjects
medicine.medical_specialty ,Population ,Coronary Artery Disease ,030204 cardiovascular system & hematology ,Coronary artery calcium ,Covid ,030218 nuclear medicine & medical imaging ,Coronary artery disease ,03 medical and health sciences ,COVID-19 Testing ,0302 clinical medicine ,Predictive Value of Tests ,Risk Factors ,Internal medicine ,Epicardial adipose tissue ,Epidemiology ,medicine ,Humans ,Pericardium ,Radiology, Nuclear Medicine and imaging ,Mortality ,Vascular Calcification ,education ,Cardiac imaging ,Retrospective Studies ,Original Paper ,education.field_of_study ,SARS-CoV-2 ,business.industry ,COVID-19 ,Retrospective cohort study ,medicine.disease ,Coronary Vessels ,medicine.anatomical_structure ,Adipose Tissue ,Predictive value of tests ,Cohort ,Cardiology ,Cardiology and Cardiovascular Medicine ,business - Abstract
Recent epidemiological studies have demonstrated that common cardiovascular risk factors are strongly associated with adverse outcomes in COVID-19. Coronary artery calcium (CAC) and epicardial fat (EAT) have shown to outperform traditional risk factors in predicting cardiovascular events in the general population. We aim to determine if CAC and EAT determined by Computed Tomographic (CT) scanning can predict all-cause mortality in patients admitted with COVID-19 disease. We performed a retrospective, post-hoc analysis of all patients admitted to Montefiore Medical Center with a confirmed COVID-19 diagnosis from March 1st, 2020 to May 2nd, 2020 who had a non-contrast CT of the chest within 5 years prior to admission. We determined ordinal CAC scores and quantified the epicardial (EAT) and thoracic (TAT) fat volume and examined their relationship with inpatient mortality. A total of 493 patients were analyzed. There were 197 deaths (39.95%). Patients who died during the index admission had higher age (72, [64–80] vs 68, [57–76]; p
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- 2021
32. Cardiac MRI findings to differentiate athlete's heart from hypertrophic (HCM), arrhythmogenic right ventricular (ARVC) and dilated (DCM) cardiomyopathy
- Author
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Sebastian Gassenmaier, K. Blume, J Brendel, S.-C. Olthof, B. Wolfarth, J Kübler, Patrick Krumm, Simon Greulich, Christof Burgstahler, Florian Hagen, Karin Klingel, and Karin Mueller
- Subjects
medicine.medical_specialty ,Athlete's heart ,Cardiomyopathy ,Contrast Media ,Gadolinium ,030204 cardiovascular system & hematology ,Athlete’s heart ,030218 nuclear medicine & medical imaging ,Muscle hypertrophy ,Both ventricles ,03 medical and health sciences ,0302 clinical medicine ,Predictive Value of Tests ,Internal medicine ,ARVC ,Medicine ,Humans ,Radiology, Nuclear Medicine and imaging ,cardiovascular diseases ,Cardiomegaly, Exercise-Induced ,Cardiac MRI ,Cardiac imaging ,Retrospective Studies ,Original Paper ,DCM ,Ejection fraction ,biology ,business.industry ,Athletes ,Heart ,Cardiomyopathy, Hypertrophic ,medicine.disease ,biology.organism_classification ,HCM ,Magnetic Resonance Imaging ,ddc ,Cardiology ,cardiovascular system ,Hypertrophy, Left Ventricular ,Cardiology and Cardiovascular Medicine ,business ,Cardiomyopathies ,Mri findings - Abstract
To provide clinically relevant criteria for differentiation between the athlete’s heart and similar appearing hypertrophic (HCM), dilated (DCM), and arrhythmogenic right-ventricular cardiomyopathy (ARVC) in MRI. 40 top-level athletes were prospectively examined with cardiac MR (CMR) in two university centres and compared to retrospectively recruited patients diagnosed with HCM (n = 14), ARVC (n = 18), and DCM (n = 48). Analysed MR imaging parameters in the whole study cohort included morphology, functional parameters and late gadolinium enhancement (LGE). Mean left-ventricular enddiastolic volume index (LVEDVI) was high in athletes (105 ml/m2) but significantly lower compared to DCM (132 ml/m2; p = 0.001). Mean LV ejection fraction (EF) was 61% in athletes, below normal in 7 (18%) athletes vs. EF 29% in DCM, below normal in 46 (96%) patients (p
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- 2021
33. Predictors of calcification distribution in severe tricuspid aortic valve stenosis
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Lisa Dannenberg, Shazia Afzal, Tobias Zeus, Ralf Westenfeld, Oliver Maier, Amin Polzin, Christian Jung, Malte Kelm, Verena Veulemans, Saif Zako, Georg Bosbach, and Kerstin Piayda
- Subjects
Aortic valve ,medicine.medical_specialty ,medicine.medical_treatment ,Aortic root ,Multi‐sliced computed tomography analysis ,TAVR ,Severity of Illness Index ,Transcatheter Aortic Valve Replacement ,Valve replacement ,Predictive Value of Tests ,Internal medicine ,Multidetector Computed Tomography ,medicine ,Humans ,Radiology, Nuclear Medicine and imaging ,Cardiac imaging ,Retrospective Studies ,Original Paper ,Severe aortic stenosis ,business.industry ,Aortic valve calcification distribution ,Aortic Valve Stenosis ,medicine.disease ,Predictive value ,medicine.anatomical_structure ,Aortic Valve ,Aortic valve stenosis ,cardiovascular system ,Cardiology ,Leaflet calcification ,Female ,Aortic valve calcification ,Cardiology and Cardiovascular Medicine ,business ,Calcification - Abstract
We investigated aortic valve calcification (AVC) distribution and predictors for leaflet calcification patterns in patients with severe tricuspid aortic valve stenosis undergoing transcatheter aortic valve replacement (TAVR). Patients undergoing routine multi-sliced computed tomography (MSCT) for procedural planning were enrolled. MSCT data were transferred to a dedicated workstation for evaluation (3mensio Structural Heart™, Pie Medical Imaging BV, Maastricht, The Netherlands) and analyzed. Participants were separated into asymmetrical (AC) and symmetrical (SC) leaflet calcification and potential predictors for calcification distribution were identified with univariate and multivariate regression analysis. 567 Participants with severe tricuspid AS were divided into asymmetrical (AC, n = 443; 78.1%) and symmetrical (SC, n = 124; 21.9%) AVC. In AC, the non-coronary cusp was the most calcified cusp (n = 238; 57.7%). SC is more common in females (AC/SC: 49.2% vs. 67.7%; p 67° (OR 1.68 [1.00–2.80], p = 0.049) as predictors for SC, although with only moderate predictive value. Data from this retrospective analysis indicate that SC occurs more frequently in females. The cumulative leaflet calcification burden is higher in patients with AC, who also present with larger aortic root dimensions. The predictive value for prominent calcification of different aortic valve cusps in AC patients was only low to moderate. Trial registration number: NCT01805739. Supplementary Information The online version contains supplementary material available at 10.1007/s10554-021-02248-6.
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- 2021
34. Sex differences in coronary plaque changes assessed by serial computed tomography angiography
- Author
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Danilo Neglia, Juhani Knuuti, Gualtiero Pelosi, Silvia Rocchiccioli, Albert Roque, Massimo Magnacca, María Nazarena Pizzi, Chiara Caselli, Bart Mertens, Arthur J.H.A. Scholte, Mohammed El Mahdiui, Jeff M. Smit, Ronny R. Buechel, Alexander R. van Rosendael, Oberdan Parodi, Anna Teresinska, Antti Saraste, University of Zurich, and Scholte, Arthur J
- Subjects
Male ,medicine.medical_specialty ,Computed Tomography Angiography ,Population ,610 Medicine & health ,030204 cardiovascular system & hematology ,Coronary Angiography ,Coronary artery disease ,2705 Cardiology and Cardiovascular Medicine ,03 medical and health sciences ,0302 clinical medicine ,Predictive Value of Tests ,Coronary plaque ,Internal medicine ,medicine ,2741 Radiology, Nuclear Medicine and Imaging ,Humans ,Coronary computed tomography angiography ,Radiology, Nuclear Medicine and imaging ,Prospective Studies ,030212 general & internal medicine ,education ,Cardiac imaging ,Computed tomography angiography ,Sex Characteristics ,Original Paper ,education.field_of_study ,medicine.diagnostic_test ,business.industry ,Infant, Newborn ,10181 Clinic for Nuclear Medicine ,medicine.disease ,Coronary Vessels ,Plaque, Atherosclerotic ,Menopause ,Atheroma ,Disease Progression ,Cardiology ,Female ,Sex ,Cardiology and Cardiovascular Medicine ,business - Abstract
Long-term data on sex-differences in coronary plaque changes over time is lacking in a low-to-intermediate risk population of stable coronary artery disease (CAD). The aim of this study was to evaluate the role of sex on long-term plaque progression and evolution of plaque composition. Furthermore, the influence of menopause on plaque progression and composition was also evaluated. Patients that underwent a coronary computed tomography angiography (CTA) were prospectively included to undergo a follow-up coronary CTA. Total and compositional plaque volumes were normalized using the vessel volume to calculate a percentage atheroma volume (PAV). To investigate the influence of menopause on plaque progression, patients were divided into two groups, under and over 55 years of age. In total, 211 patients were included in this analysis, 146 (69%) men. The mean interscan period between baseline and follow-up coronary CTA was 6.2 ± 1.4 years. Women were older, had higher HDL levels and presented more often with atypical chest pain. Men had 434 plaque sites and women 156. On a per-lesion analysis, women had less fibro-fatty PAV compared to men (β -1.3 ± 0.4%; p
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- 2021
35. Underfilling decreases left ventricular function in pulmonary arterial hypertension
- Author
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Roger Hesselstrand, Anna Bredfelt, Barbro Kjellström, Ellen Ostenfeld, Göran Rådegran, Hannah Sjögren, Håkan Arheden, and Katarina Steding-Ehrenborg
- Subjects
medicine.medical_specialty ,Ventricular Function, Left ,Pulmonary hypertension ,Ventricular Dysfunction, Left ,Predictive Value of Tests ,Cardiac magnetic resonance imaging ,Internal medicine ,medicine ,Humans ,Left atrial volume ,Radiology, Nuclear Medicine and imaging ,Pulmonary wedge pressure ,Stroke ,Cardiac imaging ,Original Paper ,Left ventricular dysfunction ,Pulmonary Arterial Hypertension ,Ejection fraction ,Ventricular function ,medicine.diagnostic_test ,business.industry ,Stroke Volume ,Stroke volume ,medicine.disease ,Cardiology ,Feature tracking strain ,Cardiology and Cardiovascular Medicine ,business - Abstract
To evaluate the association between impaired left ventricular (LV) longitudinal function and LV underfilling in patients with pulmonary arterial hypertension (PAH). Thirty-nine patients with PAH and 18 age and sex-matched healthy controls were included. LV volume and left atrial volume (LAV) were delineated in short-axis cardiac magnetic resonance (CMR) cine images. LV longitudinal function was assessed from atrio-ventricular plane displacement (AVPD) and global longitudinal strain (GLS) was assessed using feature tracking in three long-axis views. LV filling was assessed by LAV and by pulmonary artery wedge pressure (PAWP) using right heart catheterisation. Patients had a smaller LAV, LV volume and stroke volume as well as a lower LV-AVPD and LV-GLS than controls. PAWP was 6 [IQR 5––9] mmHg in patients. LV ejection fraction did not differ between groups. LV stroke volume correlated with LV-AVPD (r = 0.445, p = .001), LV-GLS (r = − 0.549, p
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- 2021
36. Diagnostic accuracy of quantitative flow ratio (QFR) and vessel fractional flow reserve (vFFR) estimated retrospectively by conventional radiation saving X-ray angiography
- Author
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Hannah Safi, Guosheng Fu, Vincenzo Tufaro, Andreas Baumbach, Anthony Mathur, Chongying Jin, Yakup Kilic, Retesh Bajaj, Anantharaman Ramasamy, and Christos V. Bourantas
- Subjects
Diagnostic accuracy ,Fractional flow reserve ,Coronary Angiography ,Single Center ,Severity of Illness Index ,QFR ,Cohort Studies ,X-ray Angiography ,Predictive Value of Tests ,Humans ,Medicine ,Radiology, Nuclear Medicine and imaging ,Cardiac imaging ,Retrospective Studies ,Original Paper ,medicine.diagnostic_test ,business.industry ,X-Rays ,Angiography ,Coronary Stenosis ,Gold standard (test) ,vFFR ,Coronary Vessels ,Fractional Flow Reserve, Myocardial ,Flow ratio ,Cardiology and Cardiovascular Medicine ,business ,Nuclear medicine - Abstract
Background Angiography derived FFR reveals good performance in assessing intermediate coronary stenosis. However, its performance under contemporary low X-ray frame and pulse rate settings is unknown. We aim to validate the feasibility and performance of quantitative flow ratio (QFR) and vessel fractional flow reserve (vFFR) under such angiograms. Methods This was an observational, retrospective, single center cohort study. 134 vessels in 102 patients, with angiograms acquired under 7.5fps and 7pps mode, were enrolled. QFR (fQFR and cQFR) and vFFR were validated with FFR as the gold standard. A conventional manual and a newly developed algorithmic exclusion method (M and A group) were both evaluated for identification of poor-quality angiograms. Results Good agreement between QFR/vFFR and FFR were observed in both M and A group, except for vFFR in the M group. The correlation coefficients between fQFR/cQFR/vFFR and FFR were 0.6242, 0.5888, 0.4089 in the M group, with rvFFR significantly lower than rfQFR (p = 0.0303), and 0.7055, 0.6793, 0.5664 in the A group, respectively. AUCs of detecting lesions with FFR ≤ 0.80 were 0.852 (95% CI 0.722–0.913), 0.858 (95% CI 0.778–0.917), 0.682 (95% CI 0.586–0.768), for fQFR/cQFR/vFFR in the M group, while vFFR performed poorer than fQFR (p = 0.0063) and cQFR (p = 0.0054). AUCs were 0.898 (95% CI 0.811–0.945), 0.892 (95% CI 0.803–0.949), 0.843 (95% CI 0.746–0.914) for fQFR/cQFR/vFFR in the A group. AUCvFFR was significantly higher in the A group than that in the M group (p = 0.0399). Conclusions QFR/vFFR assessment is feasible under 7.5fps and 7pps angiography, where cQFR showed no advantage compared to fQFR. Our newly developed algorithmic exclusion method could be a better method of selecting angiograms with adequate quality for angiography derived FFR assessment.
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- 2021
37. Prognosis of early pre-discharge and late left ventricular dilatation by cardiac magnetic resonance imaging after acute myocardial infarction
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Maxim Avanesov, Alexander Lenz, Gerhard Adam, Enver Tahir, Gunnar K. Lund, Eric Freiwald, Stefan Blankenberg, Jitka Starekova, Yskert von Kodolitsch, Maythem Saeed, M Sinn, and Kai Muellerleile
- Subjects
Male ,medicine.medical_specialty ,medicine.medical_treatment ,Myocardial Infarction ,Magnetic Resonance Imaging, Cine ,030204 cardiovascular system & hematology ,Ventricular Function, Left ,030218 nuclear medicine & medical imaging ,03 medical and health sciences ,Percutaneous Coronary Intervention ,0302 clinical medicine ,Predictive Value of Tests ,Cardiac magnetic resonance imaging ,Internal medicine ,Humans ,Medicine ,Radiology, Nuclear Medicine and imaging ,cardiovascular diseases ,Myocardial infarction ,Cardiac imaging ,Original Paper ,Ejection fraction ,medicine.diagnostic_test ,business.industry ,Hazard ratio ,Percutaneous coronary intervention ,Stroke Volume ,Left ventricle ,Prognosis ,medicine.disease ,Dilatation ,Magnetic Resonance Imaging ,Patient Discharge ,Conventional PCI ,Cardiology ,ST Elevation Myocardial Infarction ,Female ,Cardiology and Cardiovascular Medicine ,business ,Complication - Abstract
To study the long-term prognosis of early pre-discharge and late left ventricular (LV) dilatation in patients with first ST-elevation myocardial infarction (STEMI) treated by percutaneous coronary intervention (PCI) and contemporary medical therapy. Long-term follow-up > 15 years was available in 53 consecutive patients (55 ± 13 years) with first STEMI. Late gadolinium enhanced (LGE) cardiac magnetic resonance imaging (CMR) was obtained at baseline 5 ± 3 days and follow-up 8 ± 3 months after STEMI to measure LV function, volumes and infarct size. Early pre-discharge dilatation was defined as increased left ventricular end-diastolic volume index (LVEDVi) at baseline CMR with > 97 ml/m2 for males and > 90 ml/m2 for females. Late dilatation was defined as initially normal LVEDVi, which increased ≥ 20% at follow-up. Early dilatation was present in 7 patients (13%), whereas late dilatation occurred in 11 patients (21%). Patients with early LV dilatation had highest mortality (57%), whereas patients with late dilatation had similar mortality (27%) compared to patients without dilatation (26%). Multivariate Cox analysis showed that age (P P P P
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- 2021
38. Accuracy of global and regional longitudinal strain at peak of dobutamine stress echocardiography to detect significant coronary artery disease
- Author
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Adriana Postolache, Federica Ilardi, Giovanni Esposito, Patrick Marechal, Attilio Leone, Roberta Esposito, Ciro Santoro, Patrizio Lancellotti, Anna Sannino, Eugenio Stabile, Marisa Avvedimento, Raluca Elena Dulgheru, Plinio Cirillo, Giuseppe Giugliano, Ilardi, F., Santoro, C., Marechal, P., Dulgheru, R., Postolache, A., Esposito, R., Giugliano, G., Sannino, A., Avvedimento, M., Leone, A., Cirillo, P., Stabile, E., Lancellotti, P., and Esposito, G.
- Subjects
Male ,medicine.medical_specialty ,Longitudinal strain ,Dobutamine stress echocardiography ,Coronary Artery Disease ,030204 cardiovascular system & hematology ,Severity of Illness Index ,030218 nuclear medicine & medical imaging ,Coronary artery disease ,03 medical and health sciences ,0302 clinical medicine ,Predictive Value of Tests ,Dobutamine ,medicine.artery ,Internal medicine ,medicine ,Humans ,Radiology, Nuclear Medicine and imaging ,Prospective Studies ,Circumflex ,Cardiac imaging ,Aged ,Speckle tracking ,Original Paper ,business.industry ,Coronary Stenosis ,Reproducibility of Results ,Middle Aged ,medicine.disease ,Stenosis ,medicine.anatomical_structure ,Italy ,Adrenergic beta-1 Receptor Agonists ,Regional longitudinal strain ,Right coronary artery ,Cardiology ,Feasibility Studies ,Female ,Cardiology and Cardiovascular Medicine ,business ,Echocardiography, Stress ,Anterior myocardial ischemia ,Artery - Abstract
Dobutamine stress echocardiography (DSE) is sensitive but subjective diagnostic tool to detect inducible ischemia. Nowadays, speckle tracking allows an objective quantification of regional wall function. We aimed to investigate the feasibility and accuracy of global (GLS) and regional longitudinal strain (RLS) during DSE to detect significant coronary stenosis (SCS). We conducted a prospective observational multicenter study including patients undergoing DSE for suspected SCS. 50 patients with positive DSE underwent coronary angiography. Besides visual regional wall motion score index (WMSI), GLS and RLS were determined at rest and at peak stress by Automated Function Imaging. DSE GLS feasibility was 96%. Among 35 patients with SCS, 12 patients were affected by multivessel disease, 18 had stenosis of left anterior descending artery (LAD), 18 of left circumflex (LCX) and 15 of right coronary artery (RCA). At peak stress, both GLS reduction (p = 0.037) and WMSI worsening (p = 0.04) showed significant agreement with coronary angiography for detecting SCS. When single lesion was considered, peak stress GLS and LAD RLS were lower in the obstructed LAD regions than in normo-perfused territories (17.4 ± 5.5 vs. 20.5 ± 4.4%, p = 0.03; 17.1 ± 7.6 vs. 21.6 ± 5.5%, p
- Published
- 2021
39. Left atrial strain rate during atrial contraction predicts raised pulmonary capillary wedge pressure: evidence for left atrio-ventricular interaction
- Author
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Michael Y. Henein and Per Lindqvist
- Subjects
Male ,Right heart catheterization ,medicine.medical_specialty ,Heart Ventricles ,During atrial contraction ,Left atrial strain ,Strain ,Ventricular interaction ,Predictive Value of Tests ,Pulmonary capillary wedge pressure ,Internal medicine ,medicine.artery ,medicine ,Humans ,Cardiac and Cardiovascular Systems ,Radiology, Nuclear Medicine and imaging ,Heart Atria ,Pulmonary Wedge Pressure ,Pulmonary wedge pressure ,Cardiac imaging ,Original Paper ,Kardiologi ,business.industry ,Infant, Newborn ,Strain rate ,medicine.anatomical_structure ,Echocardiography ,Left atrium ,Pulmonary artery ,Vascular resistance ,Cardiology ,Cardiology and Cardiovascular Medicine ,business - Abstract
This study aimed to assess the relationship between different LA strain components and PCWP as well as to the relationship with other established methods. We studied 144 symptomatic patients, age 63 ± 14 years, 54 males, using conventional transthoracic echocardiography protocols, including LA and LV myocardial deformation from speckle tracking technique investigations along with simultaneous right heart catheterization (RHC) using established techniques. From RHC, pulmonary artery pressure (PAP), and pulmonary capillary wedge pressure (PCWP) were measured and pulmonary vascular resistance (PVR) calculated. LA strain rate during atrial contraction (LASRa) was the strongest correlate with PCWP (r2 = − 0.40, p 2 = 0.21 and 0.19, respectively, p 2 = 0.21 vs. r2 = 0.02, respectively). The strongest relationship between LASRa and PCWP was in patients with enlarged LA volume > 34 ml/m2 (r2 = 0.60, p 15 mmHg which was superior to recently proposed uni- and multi-variable models. LASR during atrial contraction is the strongest predictor of PCWP, particularly in patients with post-capillary PH and with dilated LA cavity. Furthermore, it proved superior to recently proposed uni- and multi-variable based algorithms. Its close relationship with LV strain rate counterpart reflects important left heart chamber interaction in patients with raised LA pressure.
- Published
- 2021
40. Regional shape, global function and mechanics in right ventricular volume and pressure overload conditions: a three-dimensional echocardiography study
- Author
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Egle Ereminiene, Remigijus Zaliunas, Elena Surkova, J.J. Vaskelyte, Denisa Muraru, J. Bidviene, Francesco Maffessanti, Bálint Károly Lakatos, Attila Kovács, Gianfranco Parati, Luigi P. Badano, Bidviene, J, Muraru, D, Maffessanti, F, Ereminiene, E, Kovacs, A, Lakatos, B, Vaskelyte, J, Zaliunas, R, Surkova, E, Parati, G, and Badano, L
- Subjects
Adult ,Male ,Adolescent ,Hypertension, Pulmonary ,Ventricular Dysfunction, Right ,Volume overload ,Echocardiography, Three-Dimensional ,Pulmonary hypertension ,Young Adult ,Predictive Value of Tests ,medicine ,Ventricular Pressure ,Humans ,Radiology, Nuclear Medicine and imaging ,Interventricular septum ,Cardiac Surgical Procedures ,Child ,Cardiac imaging ,Tetralogy of Fallot ,Aged ,Pressure overload ,Original Paper ,3D echocardiography ,Ventricular Remodeling ,business.industry ,Mechanics ,MED/11 - MALATTIE DELL'APPARATO CARDIOVASCOLARE ,Middle Aged ,medicine.disease ,Right ventricular function ,Regional curvature ,Echocardiography, Doppler ,Pulmonary Valve Insufficiency ,Apex (geometry) ,medicine.anatomical_structure ,Case-Control Studies ,Global function ,Ventricular Function, Right ,Right ventricular shape ,Female ,Cardiology and Cardiovascular Medicine ,business - Abstract
Our aim was to assess the regional right ventricular (RV) shape changes in pressure and volume overload conditions and their relations with RV function and mechanics. The end-diastolic and end-systolic RV endocardial surfaces were analyzed with three-dimensional echocardiography (3DE) in 33 patients with RV volume overload (rToF), 31 patients with RV pressure overload (PH), and 60 controls. The mean curvature of the RV inflow (RVIT) and outflow (RVOT) tracts, RV apex and body (both divided into free wall (FW) and septum) were measured. Zero curvature defined a flat surface, whereas positive or negative curvature indicated convexity or concavity, respectively. The longitudinal and radial RV wall motions were also obtained. rToF and PH patients had flatter FW (body and apex) and RVIT, more convex interventricular septum (body and apex) and RVOT than controls. rToF demonstrated a less bulging interventricular septum at end-systole than PH patients, resulting in a more convex shape of the RVFW (r = − 0.701, p
- Published
- 2021
41. Design of the Japanese Comprehensive Health-Economic Assessment for Appropriate Cardiac Imaging Strategy Including Outcome and Cost-Effectiveness in Stable Coronary Artery Disease Study (J-CONCIOUS)
- Author
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Tomoyuki Takura, Masato Nakamura, Tomoaki Nakata, Hiroyoshi Yokoi, Akiyoshi Hashimoto, Kenichi Nakajima, and Shun Kohsaka
- Subjects
medicine.medical_specialty ,medicine.diagnostic_test ,Diagnostic modality ,business.industry ,Cost effectiveness ,Functional ischemia ,Protocol Paper ,Cardiac outcomes ,General Medicine ,Fractional flow reserve ,Chronic coronary artery disease ,medicine.disease ,Coronary artery disease ,Angina ,Myocardial perfusion imaging ,Internal medicine ,Cardiology ,Clinical endpoint ,Medicine ,Cost-effectiveness ,Myocardial infarction ,business ,Cardiac imaging - Abstract
Background: The evaluation of stable coronary artery disease (SCAD) has evolved, and contemporary clinical practice guidelines emphasize the importance of in-depth consideration of procedure indications, risk stratification, and results of non-invasive imaging tests. However, little is known about the appropriate selection of imaging modalities for ischemia evaluation and the comparative cost-effectiveness in real-world clinical practice. Methods and Results: The Japanese Comprehensive Health-Economic Assessment for Appropriate Cardiac Imaging Strategy including Outcome and cost-effectiveness in Stable Coronary Artery Disease Study (J-CONCIOUS), a multicenter observational study, was designed to prospectively enroll 2,500 patients with suspected or known SCAD, register clinical information and administrative records, and follow patients for 3 years. Any diagnostic or cardiac imaging modality (including stress tests using electrocardiography, echocardiography, or myocardial perfusion imaging; coronary computed tomographic angiography; and/or invasive coronary angiography with or without fractional flow reserve assessment) is acceptable. Clinical endpoints, such as all-cause mortality, cardiac death, and non-fatal myocardial infarction, will be obtained, along with quality of life assessment using the Seattle Angina Questionnaire. The cost-effectiveness of individual assessment patterns will be quantified by analysis of Diagnosis Procedure Combination (DPC) data, and quality-adjusted life years and the incremental cost-effectiveness ratio will be calculated. Conclusions: J-CONCIOUS is expected to establish a risk-based and cost-effective imaging strategy for the detection and evaluation of functional myocardial ischemia and/or anatomical coronary imaging in Japan.
- Published
- 2020
42. Effects of Levosimendan on cardiac function, size and strain in heart failure patients
- Author
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Christian Loewe, Dietrich Beitzke, R Laggner, Martin Hülsmann, Daniela Senn, Richard Nolz, Andreas A. Kammerlander, Alice Wielandner, and F Gremmel
- Subjects
Male ,Cardiac function curve ,medicine.medical_specialty ,Cardiac output ,Cardiotonic Agents ,Time Factors ,Cardiac magnetic resonance ,Levosimendan ,Cardiomyopathy ,Magnetic Resonance Imaging, Cine ,Strain (injury) ,Ventricular Function, Left ,Internal medicine ,Humans ,Medicine ,Radiology, Nuclear Medicine and imaging ,cardiovascular diseases ,Simendan ,Cardiac imaging ,Aged ,Retrospective Studies ,Heart Failure ,Original Paper ,Ejection fraction ,business.industry ,Strain imaging ,Stroke Volume ,Recovery of Function ,Middle Aged ,medicine.disease ,Treatment Outcome ,Heart failure ,cardiovascular system ,Cardiology ,Female ,Cardiology and Cardiovascular Medicine ,business ,medicine.drug - Abstract
Levosimendan improves cardiac function in heart failure populations; however, its exact mechanism is not well defined. We analysed the short-term impact of levosimendan in heart failure patients with ischemic and non-ischemic cardiomyopathy (CMP) using multiparametric cardiac magnetic resonance (CMR). We identified 33 patients with ischemic or non-ischemic CMP who received two consecutive CMR scans prior to and within one week after levosimendan administration. Changes in LV ejection fraction (LVEF) and LV volumes, as well as changes in strain rates, were measured prior to and within one week after levosimendan infusion. LV scarring, based on late gadolinium enhancement (LGE), was correlated to changes in LV size and strain rates. Both LV endiastolic (EDV) and endsystolic volumes (ESV) significantly decreased (EDV: p=0,001; ESV: p=0,002) after levosimendan administration, with no significant impact on LVEF (p=0.41), cardiac output (p=0.61), and strain rates. Subgroup analyses of ischemic or non-ischemic CMP showed no significant differences between the groups in terms of short-term LV reverse remodeling. The presence and extent of scarring in LGE did not correlate with changes in LV size and strain rates. CMR is able to monitor cardiac effects of levosimendan infusion. Short-term follow-up of a single levosimendan infusion using CMR shows a significant decrease in LV size, but no impact on LVEF or strain measurements. There was no difference between patients with ischemic or non-ischemic CMP. Quantification of LV scarring in CMR is not able to predict changes in LV size and strain rates in response to levosimendan.
- Published
- 2020
43. Validity of visual assessment of aortic valve morphology in patients with aortic stenosis using two-dimensional echocardiography
- Author
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Christoph Knosalla, Sajjad Soltani, Volkmar Falk, Fabian Knebel, Felix Schoenrath, Jörg Kempfert, Julia Stein, Yuriy Hrytsyna, O. Nemchyna, Natalia Solowjowa, Axel Unbehaun, Andreas Hagendorff, and Jan Knierim
- Subjects
Adult ,Male ,Aortic valve ,medicine.medical_specialty ,Aortic valve calcium score ,Hemodynamics ,Aortic valve stenosis ,Two-dimensional echocardiography ,Visual assessment of aortic stenosis ,030204 cardiovascular system & hematology ,Severity of Illness Index ,03 medical and health sciences ,0302 clinical medicine ,Predictive Value of Tests ,Internal medicine ,Multidetector Computed Tomography ,Visual assessment ,medicine ,Humans ,Radiology, Nuclear Medicine and imaging ,030212 general & internal medicine ,Cardiac imaging ,Aged ,Retrospective Studies ,Aged, 80 and over ,Observer Variation ,Original Paper ,Sclerosis ,business.industry ,Two dimensional echocardiography ,Calcinosis ,Reproducibility of Results ,Echogenicity ,Aortic Valve Stenosis ,Middle Aged ,medicine.disease ,Stenosis ,medicine.anatomical_structure ,Echocardiography ,Aortic Valve ,Cardiology ,Female ,Cardiology and Cardiovascular Medicine ,business - Abstract
The diagnostic value of a visual assessment of aortic valve (AV) morphology for grading aortic stenosis (AS) remains unclear. A visual score (VS) for assessing the AV was developed and its reliability with respect to Doppler measurements and the calcium score (ctCS) derived by multislice computed tomography was evaluated. 99 Patients with AS of various severity and 38 patients without AS were included in the analysis. Echocardiographic studies were evaluated using the new VS which includes echogenicity, thickening, localization of lesions and leaflet mobility, with a total score ranging from 0 to 11. The association of VS with ctCS and the severity of AS was analyzed. There was a significant correlation of VS with AV hemodynamic parameters and with ctCS. The cut-off value for the detection of AS of any grade was a VS of 6 (sensitivity 95%, specificity 85% for women; sensitivity 85%, specificity 88% for men). A VS of 9 for women and of 10 for men was able to predict severe AS with a high specificity (96% in women and 94% in men, AUC 0.8 and 0.86, respectively). The same cut-off values were identified for the detection of ctCS of >= 1600 AU and >= 3000 AU with a specificity of 77% and 82% (AUC 0.69 and 0.81, respectively). Assessment of aortic valve morphology can serve as an additional diagnostic tool for the detection of AS and an estimation of its severity., The International Journal of Cardiovascular Imaging, 37 (3), ISSN:0167-9899, ISSN:1569-5794, ISSN:1573-0743
- Published
- 2020
44. Comparison of pulmonary artery dimensions in swine obtained from catheter angiography, multi-slice computed tomography, 3D-rotational angiography and phase-contrast magnetic resonance angiography
- Author
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Christopher J. François, Ryan Pewowaruk, Klarka Mendrisova, Carolina Larrain, Alejandro Roldán-Alzate, and Luke Lamers
- Subjects
Pulmonary artery imaging ,Heart Defects, Congenital ,Male ,Computed Tomography Angiography ,medicine.medical_treatment ,Sus scrofa ,Pulmonary artery stenosis ,Pulmonary Artery ,030204 cardiovascular system & hematology ,Magnetic resonance angiography ,030218 nuclear medicine & medical imaging ,03 medical and health sciences ,Imaging, Three-Dimensional ,0302 clinical medicine ,Predictive Value of Tests ,medicine.artery ,Multidetector Computed Tomography ,medicine ,Animals ,Stenosis, Pulmonary Artery ,Radiology, Nuclear Medicine and imaging ,Cardiac imaging ,Congenital heart disease ,Original Paper ,medicine.diagnostic_test ,business.industry ,Endovascular Procedures ,Reproducibility of Results ,Stent ,medicine.disease ,Disease Models, Animal ,Stenosis ,Catheter angiography ,3d rotational angiography ,Catheterization, Swan-Ganz ,Pulmonary artery ,Stents ,Cardiology and Cardiovascular Medicine ,Nuclear medicine ,business ,Magnetic Resonance Angiography - Abstract
Accurate pulmonary artery (PA) imaging is necessary for management of patients with complex congenital heart disease (CHD). The ability of newer imaging modalities such as 3D rotational angiography (3DRA) or phase-contrast magnetic resonance angiography (PC-MRA) to measure PA diameters has not been compared to established angiography techniques. Measurements of PA diameters (including PA stenosis and PA stents) from 3DRA and non-contrast-enhanced PC-MRA were compared to 2D catheter angiography (CA) and multi-slice computed tomography (MSCT) in a swine CHD model (n = 18). For all PA segments 3DRA had excellent agreement with CA and MSCT (ICC = 0.94[0.91–0.95] and 0.92[0.89–0.94]). 3DRA PA stenosis measures were similar to CA and MSCT and 3DRA was on average within 5% of 10.8 ± 1.3 mm PA stent diameters from CA and MSCT. For compliant PA segments, 3DRA was on average 3–12% less than CA (p
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- 2020
45. Automated analysis and detection of abnormalities in transaxial anatomical cardiovascular magnetic resonance images: a proof of concept study with potential to optimize image acquisition
- Author
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Nick F. Linton, Graham D. Cole, Darrel P. Francis, James P. Howard, Daniel Rueckert, Anil A. Bharath, Kerry Hall, Greg Leonard, Sharon Sutanto, Yousuf Razvi, Vijay Ramadoss, Matthew Shun-Shin, Aaraby Ragavan, Sameer Zaman, and Rosetrees Trust
- Subjects
Cardiomyopathy, Dilated ,Scanner ,medicine.medical_specialty ,Artificial intelligence ,Cardiac & Cardiovascular Systems ,030204 cardiovascular system & hematology ,Convolutional neural network ,Proof of Concept Study ,030218 nuclear medicine & medical imaging ,03 medical and health sciences ,Automation ,0302 clinical medicine ,Cardiac magnetic resonance imaging ,Predictive Value of Tests ,Machine learning ,Image Interpretation, Computer-Assisted ,Medicine ,Humans ,Radiology, Nuclear Medicine and imaging ,1102 Cardiorespiratory Medicine and Haematology ,Cardiac imaging ,Aorta ,Original Paper ,Science & Technology ,Artificial neural network ,medicine.diagnostic_test ,business.industry ,Deep learning ,Radiology, Nuclear Medicine & Medical Imaging ,Reproducibility of Results ,Magnetic resonance imaging ,Cardiomyopathy, Hypertrophic ,Magnetic Resonance Imaging ,Pleural Effusion ,Nuclear Medicine & Medical Imaging ,Great vessels ,Cardiovascular System & Cardiology ,Radiology ,Neural Networks, Computer ,Cardiology and Cardiovascular Medicine ,business ,Life Sciences & Biomedicine ,Neural networks - Abstract
The large number of available MRI sequences means patients cannot realistically undergo them all, so the range of sequences to be acquired during a scan are protocolled based on clinical details. Adapting this to unexpected findings identified early on in the scan requires experience and vigilance. We investigated whether deep learning of the images acquired in the first few minutes of a scan could provide an automated early alert of abnormal features. Anatomy sequences from 375 CMR scans were used as a training set. From these, we annotated 1500 individual slices and used these to train a convolutional neural network to perform automatic segmentation of the cardiac chambers, great vessels and any pleural effusions. 200 scans were used as a testing set. The system then assembled a 3D model of the thorax from which it made clinical measurements to identify important abnormalities. The system was successful in segmenting the anatomy slices (Dice 0.910) and identified multiple features which may guide further image acquisition. Diagnostic accuracy was 90.5% and 85.5% for left and right ventricular dilatation, 85% for left ventricular hypertrophy and 94.4% for ascending aorta dilatation. The area under ROC curve for diagnosing pleural effusions was 0.91. We present proof-of-concept that a neural network can segment and derive accurate clinical measurements from a 3D model of the thorax made from transaxial anatomy images acquired in the first few minutes of a scan. This early information could lead to dynamic adaptive scanning protocols, and by focusing scanner time appropriately and prioritizing cases for supervision and early reporting, improve patient experience and efficiency. Electronic supplementary material The online version of this article (10.1007/s10554-020-02050-w) contains supplementary material, which is available to authorized users.
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- 2020
46. Quantitative perfusion-CMR is significantly influenced by the placement of the arterial input function
- Author
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Christophe T. Arendt, Sina Bremekamp, Diana Brand, Valentina O. Puntmann, Melanie Le, Ibnul Mia, Eike Nagel, and Tommaso D'Angelo
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Signal intensity ,Male ,Ejection fraction ,Contrast Media ,Heart failure ,030204 cardiovascular system & hematology ,Coronary artery disease ,Ventricular Function, Left ,030218 nuclear medicine & medical imaging ,03 medical and health sciences ,Myocardial perfusion ,0302 clinical medicine ,Cardiac magnetic resonance imaging ,Predictive Value of Tests ,Aortic sinus ,Coronary Circulation ,medicine ,Organometallic Compounds ,Humans ,Radiology, Nuclear Medicine and imaging ,Arterial input function ,Cardiac imaging ,Aortic input function ,Cardiovascular magnetic resonance ,Aged ,Original Paper ,medicine.diagnostic_test ,business.industry ,Myocardial Perfusion Imaging ,Reproducibility of Results ,Stroke Volume ,Middle Aged ,Sinus of Valsalva ,medicine.disease ,Coronary Vessels ,Magnetic Resonance Imaging ,medicine.anatomical_structure ,Female ,Cardiology and Cardiovascular Medicine ,business ,Nuclear medicine ,Cardiomyopathies ,Perfusion - Abstract
The aim of this study is to provide a systematic assessment of the influence of the position on the arterial input function (AIF) for perfusion quantification. In 39 patients with a wide range of left ventricular function the AIF was determined using a diluted contrast bolus of a cardiac magnetic resonance imaging in three left ventricular levels (basal, mid, apex) as well as aortic sinus (AoS). Time to peak signal intensities, baseline corrected peak signal intensity and upslopes were determined and compared to those obtained in the AoS. The error induced by sampling the AIF in a position different to the AoS was determined by Fermi deconvolution. The time to peak signal intensity was strongly correlated (r2 > 0.9) for all positions with a systematic earlier arrival in the basal (− 2153 ± 818 ms), the mid (− 1429 ± 928 ms) and the apical slice (− 450 ± 739 ms) relative to the AoS (all p 2 > 0.9 for both) for all positions with a systematic overestimation in all positions relative to the AoS (all p
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- 2020
47. Myocardial involvement and deformation abnormalities in idiopathic inflammatory myopathy assessed by CMR feature tracking
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Carsten Hackenbroch, Dominik Buckert, Peter Bernhardt, Angela Rosenbohm, Meinrad Beer, Albert C. Ludolph, Ahmet Muhammed Güleroglu, and Johannes Kersten
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Adult ,Male ,medicine.medical_specialty ,Time Factors ,Cardiac magnetic resonance ,Heart Diseases ,Systole ,Diastole ,Magnetic Resonance Imaging, Cine ,Late gadolinium enhancement ,Ventricular Function, Left ,Cardiac magnetic resonance imaging ,Predictive Value of Tests ,Internal medicine ,medicine ,Humans ,Radiology, Nuclear Medicine and imaging ,cardiovascular diseases ,Cardiac imaging ,Aged ,Original Paper ,Ejection fraction ,medicine.diagnostic_test ,Myositis ,business.industry ,Strain imaging ,Stroke Volume ,Middle Aged ,Idiopathic inflammatory myopathies ,Case-Control Studies ,Idiopathic Inflammatory Myopathy ,Cardiology ,cardiovascular system ,Disease Progression ,Feature tracking ,Female ,Cardiology and Cardiovascular Medicine ,business - Abstract
Background Cardiac involvement has been described in idiopathic inflammatory myopathies (IIM), including non-specific ECG and echocardiographic findings. Aim of our study was to evaluate myocardial deformation parameters in IIM and to correlate them with late gadolinium enhancement (LGE) findings using cardiac magnetic resonance imaging (CMR). Methods Forty-seven consecutive patients with histologically proven IIM were included into our study. Twenty-five healthy volunteers were used as a control group. All patients and controls underwent CMR examination using a 1.5 T scanner including functional cine and LGE imaging. After a mean follow-up of 234.7 ± 79.5 days a second CMR examination was performed in IIM patients. Results In comparison to healthy volunteers, IIM patients had lower left ventricular mass and left ventricular global radial, circumferential and longitudinal strain. There was no significant difference in left ventricular ejection fraction. Patients with LGE (N = 28) had lower left ventricular ejection fraction (p = 0.016), global right and left ventricular longitudinal strain (p = 0.014 and p = 0.005) and global left ventricular diastolic longitudinal strain rate (p = 0.001) compared to patients without LGE (N = 19). In IIM patients, a significant decrease of left ventricular ejection fraction, left ventricular mass and all measured deformation parameters was observed between baseline and follow-up CMR. Conclusion Cardiac involvement in IIM is frequent. Impairment of systolic and diastolic deformation parameters and a worsening over time can be observed. CMR is a useful tool for cardiac diagnostic work-up of these patients.
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- 2020
48. Acute pulmonary embolism multimodality imaging prior to endovascular therapy
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Gordon McLennan, Fabian Rengier, Matthias A. Fink, David Sin, Gustavo A. Heresi, Sasan Partovi, Dustin Thompson, John R. Bartholomew, and Ihab Haddadin
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medicine.medical_specialty ,Computed Tomography Angiography ,Perfusion Imaging ,Clinical Decision-Making ,Pulmonary Artery ,030204 cardiovascular system & hematology ,Endovascular therapy ,Acute pulmonary embolism ,Magnetic resonance angiography ,030218 nuclear medicine & medical imaging ,03 medical and health sciences ,0302 clinical medicine ,Predictive Value of Tests ,medicine ,Humans ,Radiology, Nuclear Medicine and imaging ,In patient ,Cardiac imaging ,Ventilation–perfusion scan ,Review Paper ,medicine.diagnostic_test ,Ventilation/perfusion scan ,business.industry ,Endovascular Procedures ,medicine.disease ,Pulmonary embolism ,Computed tomography pulmonary angiography ,Catheter ,Acute Disease ,Right heart ,Radiology ,Pulmonary Embolism ,Cardiology and Cardiovascular Medicine ,business - Abstract
The manuscript discusses the application of CT pulmonary angiography, ventilation–perfusion scan, and magnetic resonance angiography to detect acute pulmonary embolism and to plan endovascular therapy. CT pulmonary angiography offers high accuracy, speed of acquisition, and widespread availability when applied to acute pulmonary embolism detection. This imaging modality also aids the planning of endovascular therapy by visualizing the number and distribution of emboli, determining ideal intra-procedural catheter position for treatment, and signs of right heart strain. Ventilation–perfusion scan and magnetic resonance angiography with and without contrast enhancement can also aid in the detection and pre-procedural planning of endovascular therapy in patients who are not candidates for CT pulmonary angiography.
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- 2020
49. Evaluation of biventricular function in patients with COVID-19 using speckle tracking echocardiography
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Omer Faruk Baycan, Adem Tatlısu, Hasan Ali Barman, Mustafa Caliskan, Sacit Icten, Adem Atici, furkan bolen, Barış Güngör, Pınar Ergen, and İÜC, Cerrahpaşa Tıp Fakültesi, Dahili Tıp Bilimleri Bölümü
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Male ,medicine.medical_specialty ,Biventricular function ,Multivariate analysis ,Coronavirus disease 2019 (COVID-19) ,Heart Ventricles ,Ventricular Dysfunction, Right ,Speckle tracking echocardiography ,Ventricular Dysfunction, Left ,Internal medicine ,Clinical endpoint ,medicine ,Humans ,Radiology, Nuclear Medicine and imaging ,Prospective Studies ,Cardiac imaging ,Original Paper ,SARS-CoV-2 ,business.industry ,Medical record ,COVID-19 ,Outbreak ,Middle Aged ,Confidence interval ,Echocardiography ,Radiology Nuclear Medicine and imaging ,Female ,Cardiology and Cardiovascular Medicine ,business - Abstract
WOS:000560834200001 PubMed ID: 32803484 A new infectious outbreak sustained by severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) is now spreading all around the world. The aim of this study was to evaluate the prognostic value of left ventricular global longitudinal strain (LV-GLS) and right ventricular longitudinal strain (RV-LS) in patients with coronavirus disease 2019 (COVID-19). In this prospective, single-center study, data were gathered from patients treated for COVID-19 between April 15 and April 30, 2020. Two-dimensional echocardiography (2-DE) and speckle tracking echocardiography (STE) images were obtained for all patients. Patients were divided into three groups: those with severe COVID-19 infection, those with non-severe COVID-19 infection, and those without COVID-19 infection (the control group). Data regarding clinical characteristics and laboratory findings were obtained from electronic medical records. The primary endpoint was in-hospital mortality. A total of 100 patients hospitalized for COVID-19 were included in this study. The mean age of the severe group (n = 44) was 59.1 +/- 12.9, 40% of whom were male. The mean age of the non-severe group (n = 56) was 53.7 +/- 15.1, 58% of whom were male. Of these patients, 22 died in the hospital. In patients in the severe group, LV-GLS and RV-LS were decreased compared to patients in the non-severe and control groups (LV-GLS: - 14.5 +/- 1.8 vs. - 16.7 +/- 1.3 vs. - 19.4 +/- 1.6, respectively [p < 0.001]; RV-LS: - 17.2 +/- 2.3 vs. - 20.5 +/- 3.2 vs. - 27.3 +/- 3.1, respectively [p < 0.001]). The presence of cardiac injury, D-dimer, arterial oxygen saturation (SaO2), LV-GLS (OR 1.63, 95% confidence interval [CI] 1.08-2.47; p = 0.010) and RV-LS (OR 1.55, 95% CI 1.07-2.25; p = 0.019) were identified as independent predictors of mortality via multivariate analysis. LV-GLS and RV-LS are independent predictors of in-hospital mortality in patients with COVID-19.
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- 2020
50. Disproportionate mitral regurgitation: another myth? A critical appraisal of echocardiographic assessment of functional mitral regurgitation
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Stephan Stöbe, Andreas Hagendorff, Fabian Knebel, Volkmar Falk, Andreas Helfen, and Torsten Doenst
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medicine.medical_specialty ,Cardiac output ,Percutaneous ,Hemodynamics ,Effective Regurgitant Orifice Area ,Severity of Illness Index ,law.invention ,Randomized controlled trial ,law ,Predictive Value of Tests ,Internal medicine ,Functional mitral regurgitation ,Disproportionate mitral regurgitation ,Regurgitant fraction ,Echocardiography ,medicine ,Humans ,Radiology, Nuclear Medicine and imaging ,Cardiac imaging ,Mitral regurgitation ,Review Paper ,business.industry ,Mitral Valve Insufficiency ,Reproducibility of Results ,Cardiology ,cardiovascular system ,Mitral Valve ,Cardiology and Cardiovascular Medicine ,business - Abstract
The contradictory findings of recent prospective randomized controlled trials assessing the impact of percutaneous edge-to-edge repair in patients with functional or secondary mitral regurgitation have triggered a lively discussion about an "integrated" echocardiographic approach for grading severity of mitral regurgitation. In the MITRA-FR trial, the COAPT trial and the REDUCE-FMR trial echocardiographic assessment of the severity of mitral regurgitation was consistent with principles set forth by the current echocardiographic guidelines and analysed in its best settings by expert international leaders in the field of echocardiography. However, serious inconsistencies appeared in the presented echocardiographic assessments regarding cardiac output and regurgitant fraction. A new term "disproportionate functional mitral regurgitation" was introduced describing a situation where the increase of effective regurgitant orifice area exceeds the enlargement of the left ventricular end-diastolic volumes. Further discussion resulted in the idea of a "new conceptional framework" for distinguishing "proportionate" and "disproportionate" functional mitral regurgitation. The aim of this viewpoint is to dispute conclusions based on the term "disproportionate" mitral regurgitation. A "disproportionate" FMR is highly questionable because disproportionateness of flow in communication vessels cannot exist. In addition, a proposal of echocardiographic assessment based on a conventional comprehensive transthoracic echocardiography is given to avoid obvious hemodynamic contradictions., The International Journal of Cardiovascular Imaging, 37, ISSN:0167-9899, ISSN:1569-5794, ISSN:1573-0743
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- 2020
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