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1. Outcomes After Minimally-invasive Versus Open Pancreatoduodenectomy: A Pan-European Propensity Score Matched Study

Author: Klompmaker, S., Hilst, J. van, Wellner, U.F., Busch, O.R., Coratti, A., D'Hondt, M., Dokmak, S., Festen, S., Kerem, M., Khatkov, I., Lips, D.J., Lombardo, C., Luyer, M., Manzoni, A., Molenaar, I.Q., Rosso, E., Saint-Marc, O., Vansteenkiste, F., Wittel, U.A., Bonsing, B., Koerkamp, B.G., Abu Hilal, M., Fuks, D., Poves, I., Keck, T., Boggi, U., Besselink, M.G., European Consortium Minimally Inva, Graduate School, AGEM - Digestive immunity, AGEM - Endocrinology, metabolism and nutrition, AGEM - Re-generation and cancer of the digestive system, CCA - Cancer Treatment and Quality of Life, and Surgery
Subjects: Male, robotic, medicine.medical_specialty, Percutaneous, pancreatic cancer, pancreatic tumors, laparoscopic, Pancreaticoduodenectomy, surgery, 03 medical and health sciences, 0302 clinical medicine, Pan european, Interquartile range, medicine, Humans, Minimally Invasive Surgical Procedures, pancreas, Propensity Score, Aged, Retrospective Studies, High rate, hybrid, propensity score matching, business.industry, Pancreatic Diseases, Retrospective cohort study, robot, Odds ratio, Length of Stay, Middle Aged, medicine.disease, Whipple, Surgery, Europe, Outcome and Process Assessment, Health Care, Pancreatic fistula, 030220 oncology & carcinogenesis, Propensity score matching, minimally invasive, Female, 030211 gastroenterology & hepatology, business
Abstract: OBJECTIVE: To assess short-term outcomes after minimally invasive (laparoscopic, robot-assisted, and hybrid) pancreatoduodenectomy (MIPD) versus open pancreatoduodenectomy (OPD) among European centers. BACKGROUND: Current evidence on MIPD is based on national registries or single expert centers. International, matched studies comparing outcomes for MIPD and OPD are lacking. METHODS: Retrospective propensity score matched study comparing MIPD in 14 centers (7 countries) performing ≥10 MIPDs annually (2012-2017) versus OPD in 53 German/Dutch surgical registry centers performing ≥10 OPDs annually (2014-2017). Primary outcome was 30-day major morbidity (Clavien-Dindo ≥3). RESULTS: Of 4220 patients, 729/730 MIPDs (412 laparoscopic, 184 robot-assisted, and 130 hybrid) were matched to 729 OPDs. Median annual case-volume was 19 MIPDs (interquartile range, IQR 13-22), including the first MIPDs performed in 10/14 centers, and 31 OPDs (IQR 21-38). Major morbidity (28% vs 30%, P = 0.526), mortality (4.0% vs 3.3%, P = 0.576), percutaneous drainage (12% vs 12%, P = 0.809), reoperation (11% vs 13%, P = 0.329), and hospital stay (mean 17 vs 17 days, P > 0.99) were comparable between MIPD and OPD. Grade-B/C postoperative pancreatic fistula (POPF) (23% vs 13%, P < 0.001) occurred more frequently after MIPD. Single-row pancreatojejunostomy was associated with POPF in MIPD (odds ratio, OR 2.95, P < 0.001), but not in OPD. Laparoscopic, robot-assisted, and hybrid MIPD had comparable major morbidity (27% vs 27% vs 35%), POPF (24% vs 19% vs 25%), and mortality (2.9% vs 5.2% vs 5.4%), with a fewer conversions in robot-assisted- versus laparoscopic MIPD (5% vs 26%, P < 0.001). CONCLUSIONS: In the early experience of 14 European centers performing ≥10 MIPDs annually, no differences were found in major morbidity, mortality, and hospital stay between MIPD and OPD. The high rates of POPF and conversion, and the lack of superior outcomes (ie, hospital stay, morbidity) could indicate that more experience and higher annual MIPD volumes are needed.
Published: 2020

2. Clinical approach on challenge and desensitization procedures with aspirin in patients with ischemic heart disease and nonsteroidal anti-inflammatory drug hypersensitivity

Author: Cortellini, G, Romano, A, Santucci, A, Barbaud, A, Bavbek, S, Bignardi, D, Blanca, M, Bonadonna, P, Costantino, M T, Laguna, J J, Lombardo, C, Losappio, L M, Makowska, J, Nakonechna, A, Quercia, O, Pastorello, E A, Patella, V, Terreehorst, I, Testi, S, Cernadas, J R, EAACI Drug Interest Group on Challenge and Desensitization Procedures with Aspirin in CAD, Dionicio Elera, J, Lippolis, D, Voltolini, S, Grosseto, D, Paediatric Pulmonology, Ear, Nose and Throat, and Amsterdam Cardiovascular Sciences
Subjects: Male, Acute coronary syndrome, Allergy, aspirin, medicine.medical_treatment, Immunology, Clinical Decision-Making, Myocardial Ischemia, challenge procedure, Comorbidity, 030204 cardiovascular system & hematology, nonsteroidal anti-inflammatory drugs hypersensitivity, Bronchospasm, Coronary artery disease, Drug Hypersensitivity, 03 medical and health sciences, 0302 clinical medicine, medicine, Immunology and Allergy, Humans, Desensitization (medicine), Aged, Aspirin, Angioedema, business.industry, Settore MED/09 - MEDICINA INTERNA, Anti-Inflammatory Agents, Non-Steroidal, Middle Aged, medicine.disease, desensitization procedure, Treatment Outcome, 030228 respiratory system, Desensitization, Immunologic, Anesthesia, Female, medicine.symptom, business, Anaphylaxis, Algorithms, medicine.drug
Abstract: Background Hypersensitivity to acetylsalicylic acid (ASA) constitutes a serious problem for subjects with coronary artery disease. In such subjects, physicians have to choose the more appropriate procedure between challenge and desensitization. As the literature on this issue is sparse, the present study aims to establish in these subjects clinical criteria for eligibility for an ASA challenge and/or desensitization. Methods Collection and analysis of data on ASA challenges and desensitizations from 10 allergy centers, as well as consensus among the related physicians and an expert panel. Results Altogether, 310 subjects were assessed; 217 had histories of urticaria/angioedema, 50 of anaphylaxis, 26 of non-immediate cutaneous eruptions, and 17 of bronchospasm related to ASA/NSAID intake. Specifically, 119 subjects had index reactions to ASA doses lower than 300 mg. Of the 310 subjects, 138 had an acute coronary syndrome (ACS), 101 of whom underwent desensitizations, whereas 172 suffered from a chronic ischemic heart disease (CIHD), 126 of whom underwent challenges. Overall, 163 subjects underwent challenges and 147 desensitizations; 86 of the latter had index reactions to ASA doses of 300 mg or less. Ten subjects reacted to challenges, 7 at doses up to 500 mg, 3 at a cumulative dose of 110 mg. The desensitization failure rate was 1.4%. Conclusions In patients with stable CIHD and histories of non-severe hypersensitivity reactions to ASA/NSAIDs, an ASA challenge is advisable. Patients with an ACS and histories of hypersensitivity reactions to ASA, especially following doses lower than 100 mg, should directly undergo desensitization. This article is protected by copyright. All rights reserved.
Published: 2017

3. Outcomes and Risk Score for Distal Pancreatectomy with Celiac Axis Resection (DP-CAR) : An International Multicenter Analysis

Author: Klompmaker, S., Peters, N. A., van Hilst, J., Bassi, C., Boggi, U., Busch, O. R., Niesen, W., Van Gulik, T. M., Javed, A. A., Kleeff, J., Kawai, M., Lesurtel, M., Lombardo, C., Moser, A. J., Okada, K. -I., Popescu, I., Prasad, R., Salvia, R., Sauvanet, A., Sturesson, C., Weiss, M. J., Zeh, H. J., Zureikat, A. H., Yamaue, H., Wolfgang, C. L., Hogg, M. E., Besselink, M. G., Gerritsen, S. L., Adham, M., Albiol Quer, M. T., Berrevoet, F., Cesaretti, M., Dalla Valle, R., Darnis, B., Diener, M. K., Del Chiaro, M., Hackert, T. H., Grutzmann, R., Dumitrascu, T., Friess, H., Hirono, S., Ivanecz, A., Karayiannakis, A., Fusai, G. K., Labori, K. J., Lopez-Ben, S., Mabrut, J. -Y., Miyazawa, M., Pardo, F., Perinel, J., Roeyen, G., Graduate School, CCA - Cancer Treatment and Quality of Life, AGEM - Digestive immunity, AGEM - Re-generation and cancer of the digestive system, AGEM - Endocrinology, metabolism and nutrition, Surgery, CCA - Cancer biology and immunology, AGEM - Amsterdam Gastroenterology Endocrinology Metabolism, and E-AHPBA DP-CAR Study Grp
Subjects: Male, medicine.medical_specialty, Pancreatic Neoplasms/pathology, SURGERY, medicine.medical_treatment, Pancreatectomy/mortality, Pancreatectomy, Celiac artery, Celiac Artery, Pancreatic cancer, medicine.artery, Medicine and Health Sciences, Aged, Female, Follow-Up Studies, Humans, Middle Aged, Pancreatic Neoplasms, Retrospective Studies, Survival Rate, Treatment Outcome, Patient Selection, Journal Article, Medicine, Survival rate, ARTERY, Framingham Risk Score, business.industry, Mortality rate, Celiac Artery/surgery, ADENOCARCINOMA, Retrospective cohort study, medicine.disease, Surgery, ddc, MODEL, Multicenter Study, DEFINITION, Oncology, Hepatobiliary Tumors, VOLUME, Adenocarcinoma, Human medicine, business
Abstract: Background Distal pancreatectomy with celiac axis resection (DP-CAR) is a treatment option for selected patients with pancreatic cancer involving the celiac axis. A recent multicenter European study reported a 90-day mortality rate of 16%, highlighting the importance of patient selection. The authors constructed a risk score to predict 90-day mortality and assessed oncologic outcomes. Methods This multicenter retrospective cohort study investigated patients undergoing DP-CAR at 20 European centers from 12 countries (model design 2000–2016) and three very-high-volume international centers in the United States and Japan (model validation 2004–2017). The area under receiver operator curve (AUC) and calibration plots were used for validation of the 90-day mortality risk model. Secondary outcomes included resection margin status, adjuvant therapy, and survival. Results For 191 DP-CAR patients, the 90-day mortality rate was 5.5% (95 confidence interval [CI], 2.2–11%) at 5 high-volume (≥ 1 DP-CAR/year) and 18% (95 CI, 9–30%) at 18 low-volume DP-CAR centers (P = 0.015). A risk score with age, sex, body mass index (BMI), American Society of Anesthesiologists (ASA) score, multivisceral resection, open versus minimally invasive surgery, and low- versus high-volume center performed well in both the design and validation cohorts (AUC, 0.79 vs 0.74; P = 0.642). For 174 patients with pancreatic ductal adenocarcinoma, the R0 resection rate was 60%, neoadjuvant and adjuvant therapies were applied for respectively 69% and 67% of the patients, and the median overall survival period was 19 months (95 CI, 15–25 months). Conclusions When performed for selected patients at high-volume centers, DP-CAR is associated with acceptable 90-day mortality and overall survival. The authors propose a 90-day mortality risk score to improve patient selection and outcomes, with DP-CAR volume as the dominant predictor. Electronic supplementary material The online version of this article (10.1245/s10434-018-07101-0) contains supplementary material, which is available to authorized users.
Published: 2019

4. The Italian START-Register on anticoagulation with focus on atrial fibrillation

Author: Antonucci, E, Poli, D, Tosetto, A, Pengo, V, Tripodi, A, Magrini, N, Marongiu, F, Palareti, G, Testa, S, Paoletti, O, Falanga, A, Lerede, T, Guazzaloca, G, Marcucci, R, Piana, A, Cibecchini, F, Ruocco, L, Lucarelli, G, Paparo, C, Martini, G, Scovoli, G, Bradamante, S, Malcangi, G, Lombardi, M, Insana, A, Toma, A, Barbera, P, Masciocco, L, Saracino, P, Benvenuto, A, Vasselli, C, Sangiorgio, R, Crippa, L, Pedrini, S, Bertola, F, Rupoli, S, Lion,e D, Pasca, S, Roldan, V, Rossi, V, Bucherini, E, Gresele, P, Mangione C, Cicconi, S, Casasco, P, Castaman, G, Liberato, NL, Bendotti, C, Oriana, V, Manotti, P, Zighetti, ML, Pedico, P, Fidone, E, Lombardo, C, Paci, OO, Pezzella, S, Pezzo, M, Ciampa, A, Maccaroni, I, Molini, G, Ciardiello, A, Marietta, M, Turrini, A, Barcellona, D, Antonucci, E, Poli, D, Tosetto, A, Pengo, V, Tripodi, A, Magrini, N, Marongiu, F, Palareti, G, Testa, S, Paoletti, O, Falanga, A, Lerede, T, Guazzaloca, G, Marcucci, R, Piana, A, Cibecchini, F, Ruocco, L, Lucarelli, G, Paparo, C, Martini, G, Scovoli, G, Bradamante, S, Malcangi, G, Lombardi, M, Insana, A, Toma, A, Barbera, P, Masciocco, L, Saracino, P, Benvenuto, A, Vasselli, C, Sangiorgio, R, Crippa, L, Pedrini, S, Bertola, F, Rupoli, S, Lion, E, Pasca, S, Roldan, V, Rossi, V, Bucherini, E, Gresele, P, Mangione, C, Cicconi, S, Casasco, P, Castaman, G, Liberato, N, Bendotti, C, Oriana, V, Manotti, P, Zighetti, M, Pedico, P, Fidone, E, Lombardo, C, Paci, O, Pezzella, S, Pezzo, M, Ciampa, A, Maccaroni, I, Molini, G, Ciardiello, A, Marietta, M, Turrini, A, and Barcellona, D
Subjects: Genetics and Molecular Biology (all), Male, medicine.medical_specialty, lcsh:Medicine, Renal function, Hemorrhage, Biochemistry, Atrial Fibrillation, coagulation, anticoagulation, Cohort Studies, chemistry.chemical_compound, Interquartile range, Risk Factors, Internal medicine, Atrial Fibrillation, medicine, 80 and over, Humans, Registries, Renal Insufficiency, lcsh:Science, Stroke, Aged, Aged, 80 and over, Creatinine, Multidisciplinary, business.industry, Anticoagulants, Female, Italy, Middle Aged, Medicine (all), lcsh:R, Atrial fibrillation, medicine.disease, Surgery, Clinical trial, Agricultural and Biological Sciences (all), chemistry, Biochemistry, Genetics and Molecular Biology (all), lcsh:Q, Observational study, business, Research Article, Cohort study
Abstract: START-Register - Survey on anTicoagulated pAtients RegisTer - is an independent, inception-cohort, observational, collaborative database aimed at recording prospectively the clinical history of adult patients starting anticoagulant treatment for any reason and using whatever drug. In this article we present the START-Register and give cross section baseline data focusing on non valvular atrial fibrillation (NVAF). Participants are asked to insert prospectively consecutive patients recorded as electronic file on the web-site of the registry. Required data are: demographic and clinical characteristics of patients, associated risk factors for stroke and bleeding, laboratory routine data, clinical indication for treatment, expected therapeutic range (in cases of treatment with vitamin K antagonists -VKAs). The follow-up is carried out to record: quality of treatment (for patients on VKAs), bleeding complications, thrombotic events, and the onset of any type of associated disease. To date 5252 patients have been enrolled; 97.6% were on VKAs because direct oral anticoagulants (DOAC) have been available in Italy only recently. The median age was 74 years [interquartile range (IQR) 64-80]; males 53.7%. This analysis is focused on the 3209 (61.1%) NVAF patients. Mean CHADS2 score was 2.1±1.1, CHADSVASc score was 3.1±1.3;median age was 76 years (IQR 70-81); 168 patients (5.3%) had severe renal failure [Creatinine clearance (CrCl) 80 years with high prevalence of renal failure.
Published: 2015

5. Calibration strategy of the JUNO experiment

Author: Andrea Barresi, Muhammad Usman Rajput, Chengzhuo Yuan, Demin Li, Cédric Huss, Jie Zhao, Xianghui Yu, W. H. Huang, Feng Gao, Sen Qian, Patrick Kinz, Miao He, Axel Müller, Davit Mayilyan, Utane Sawangwit, Jacques Wurtz, Wenju Huo, Hang Hu, Guanghua Gong, G. Andronico, Giuseppe Verde, Si Ma, Livia Ludhova, Xiaoyu Yang, Lucia Votano, Waqas Muhammad, Oleg Smirnov, Jie Yang, Zhe Ning, Y. X. Zhang, Zhuang Shao, Jun Wang, Martin Dvorak, Hao Liang, Nikolay Morozov, Ara Ioannisian, Qingmin Zhang, Ezio Previtali, Barbara Ricci, Ints Mednieks, Wuming Luo, Rossella Caruso, Diru Wu, Alexander Studenikin, Sadia Marium, Jingbo Zhang, M. Settimo, A. Popov, Enrico Bernieri, Xiaowei Liu, Yumei Zhang, Anut Sangka, Feipeng Ning, F. Z. Qi, Simon Blyth, Anatael Cabrera, Antonio Insolia, Donglian Xu, Amir N. Khan, Minghao Gu, Daniel Liebau, Shouyang Hu, Thilo Birkenfeld, Mengyun Guan, Gérard Claverie, Xin Mao, Xingtao Huang, Guoqing Zhang, Markus Robens, Jari Joutsenvaara, Zhibing Li, Can Fang, Nuanwan Sanguansak, Andrey Formozov, Ugur Yegin, Yuekun Heng, Xiaohui Qian, Riccardo Bruno, Zafar Yasin, Selma Conforti Di Lorenzo, Weidong Li, Xiaonan Li, Cédric Schwab, Yuguang Xie, Narumon Suwonjandee, Michael Wurm, Teerapat Payupol, Andrea Serafini, Chunhao Huang, Fangliang Wu, Haoqi Lu, Di Jiang, Salvatore Costa, Yue Meng, Y. Sun, S. Dusini, Mathieu Roche, Stefano Maria Mari, S. Parmeggiano, N. Raper, M. A. Szelezniak, W. J. Wu, Jingbin Lu, Heike Enzmann, Nan Li, Zhonghua Qin, Min Liu, Q. J. Li, Tobias Heinz, Frédéric Druillole, Qun Wu, Anbo Yang, Hongjuan Liu, Sukit Limpijumnong, Peihuai Yi, Cecilia Landini, Jonathan Miller, Yu Xu, Agnese Martini, Vito Antonelli, A. Bolshakova, Alexandre Göttel, X. L. Ji, Yuanqing Wang, Haonan Gan, Lei Yang, Sebastiano Aiello, Leonidas Kalousis, Andre Zambanini, R. T. Lei, Stefan van Waasen, Dmitry Selivanov, Khanchai Khosonthongkee, Yanke Cai, F. Yermia, Yuman Wang, Rong Zhao, Jian Wang, E. Meroni, Filippo Marini, Narine Kazarian, Y. F. Wang, Shanfeng Li, Q. An, Alessandra Re, Chung-Hsiang Wang, Agnese Giaz, Tingxuan Zeng, Guihong Huang, Andrej Babic, Fabio Mantovani, Fang Liu, Richard Ford, Zhe Wang, Christian Grewing, Antonio Bergnoli, Warintorn Sreethawong, Georgy Donchenko, S. Krokhaleva, Mengzhao Li, Rupert Leitner, Monica Sisti, Domizia Orestano, Mario Buscemi, Paolo Montini, Marco Grassi, Zeyuan Yu, Tobias Lachenmaier, Jianrun Hu, Victor Lebrin, Angel Abusleme, Boxiang Yu, Tao Li, Maciej Slupecki, Boonrucksar Soonthornthum, Catia Clementi, Marco Giammarchi, Francesco Manzali, B. Z. Hu, Virginia Strati, Alexey Krasnoperov, Zhang Chen, Hua Zheng, P. Saggese, Minshan Zheng, Xiaolu Ji, Gisele Martin-Chassard, Matthias Raphael Stock, Pablo Walker, Jose Busto, Agustin Campeny, Burin Asavapibhop, Yinhong Zhang, S. B. Liu, Vitaly Shutov, Barbara Clerbaux, Peng Zhang, Zhengyun You, Yayun Ding, Shubin Liu, Ayut Limphirat, S. Dmitrievsky, Siyu Jian, S. Sanfilippo, Cristina Tuve, Shoukang Qiu, Shifeng Sun, Jie Ren, Sébastien Leblanc, Po-An Chen, Xubo Ma, Safeer Hussain, Guangpeng An, Nicomede Pelliccia, Yuhang Guo, Shan Zeng, Konstantin A. Kouzakov, Shaojing Hou, Jing Xu, X. H. Guo, Feiyang Zhang, Dongqin Zheng, Ilya Butorov, Maria Gul, Kunyu Wang, Claudio Lombardo, Zhi Deng, Zhiyan Cai, Yu Gu, Yufei Xi, K. Loo, R. Brugnera, Shu Luo, Jiaheng Zou, Ran Han, Giancarlo Troni, M. H. Ye, Xiaoxu Lu, Fengjiao Luo, H. D. Liu, Haitao Li, Fei Li, Julanan Songwadhana, Xiaomei Zhang, Fengpeng An, X. D. Ruan, Chunxu Yu, Vadim Vedin, Mauro Mezzetto, Jiaqi Li, Caren Hagner, Shu Zhang, Wander Baldini, Yangheng Zheng, Antonio Budano, Michele Montuschi, Zheng Wang, Qin Liu, Pierre-Alexandre Petitjean, Xuefeng Ding, H. R. Pan, Lukas Fajt, Jingyan Shi, David Meyhöfer, Fanrong Xu, Marco Bellato, Zhenyu Zhang, S. J. Zhao, Clément Bordereau, Yan Zhang, Bayarto Lubsandorzhiev, Guang Luo, Benda Xu, Xiangyue Wang, Christophe De La Taille, Miao Yu, Christian Roth, Nina Parkalian, Andrea Fabbri, Fausto Ortica, João Pedro Athayde Marcondes de André, Y. Wang, Liangjian Wen, S. X. Du, Jian Tang, Frederic Lefevre, Tao Hu, Vasily Gromov, Guofu Cao, Liang Zhan, E. Doroshkevich, Steven Chan-Fai Wong, Amélie Fournier, Apimook Watcharangkool, Jinchang Liu, Qian Liu, Yongbo Huang, Bayu Dirgantara, Chiara Sirignano, Qiumei Ma, Yi Wang, A. Sadovsky, Xichao Ruan, Caishen Wang, G. Settanta, Flavio Dal Corso, Beatrice Jelmini, Guillaume Vanroyen, Baojun Yan, Ruhui Li, Mikhail Smirnov, Huan Yang, Z. Wu, Xiao Cai, Yun Chang, Meng Wang, Yufeng Li, Tianchi Zhao, K. L. Jen, Li-Cheng Feng, Guey-Lin Lin, Shuxiang Lu, Massimiliano Nastasi, Thomas Adam, Rizwan Ahmed, David Blum, Marco Fargetta, Didier Auguste, Weiguo Li, Jian Fang, Patrick Hellmuth, Muhammad Akram, Hui Liu, Tomas Tmej, G. X. Sun, Fengyi Zhao, Christian Wysotzki, Wladyslaw Henryk Trzaska, Achim Stahl, Sylvie Blin, Yin Xu, Alexander Tietzsch, Fedor Šimkovic, Haiping Peng, Ziping Ye, Baobiao Yue, A. Sotnikov, Aldo Romani, Anna Chuvashova, Noman Zafar, Tatiana Antoshkina, Wanlei Guo, C. Jollet, Christoph Genster, Sultim Lubsandorzhiev, Y. K. Sun, Xiangwei Yin, Xiaoping Jing, H. Steiger, Muhammad Sohaib Hassan, Cristina Martellini, Wei Wang, B. Viaud, Igor Nemchenok, Zhijian Zhang, Fatma Sawy, Xiaofei Gu, Alexander Olshevskiy, Liang Zong, Pavithra Muralidharan, Xiaomei Li, Alexandr Selyunin, Yu Chen, Jochen Steinmann, Qiang Tang, Daojin Hong, Daniele Corti, Yatian Pei, S. Zhang, Denis Korablev, Yi Chen, Dominique Breton, Franco Giuliani, F. Li, Augusto Brigatti, Artem Chukanov, Nikolaos Vassilopoulos, Jiaxuan Ye, Yi-Wen Chen, K. Treskov, Michael Karagounis, Haiqiong Zhang, Jiang Zhu, Nunzio Giudice, Zongyi Wang, H. L. Zhuang, Marco Aurelio Diaz, Nikolay Kutovskiy, Shakeel Ahmad, Narongkiat Rodphai, Yifan Yang, Huihui Jia, Juan Pedro Ochoa-Ricoux, Jin Li, Hongtao Liu, Andrey Sidorenkov, Qichun Feng, Jiawen Zhang, T. Enqvist, Ruyi Jin, J. J. Ling, Arseniy Rybnikov, Lino Miramonti, Yi Li, Luis Felipe Piñeres Rico, Ziyuan Li, Ziyi Yuan, A. Lokhov, Jie Cheng, Rafael Herrera, Jiaqi Hui, Wathan Pratumwan, En Wang, Konstantin Schweizer, A. Kruth, Tobias Sterr, Shengxin Lin, Anna Fatkina, Fabrizio Petrucci, Mathieu Bongrand, Olivia Dalager, Alessandro Paoloni, Philipp Kampmann, Roberto Isocrate, Jianmeng Dong, Weirong Zhong, Yiyu Zhang, Saroj Rujirawat, Giuseppe Salamanna, Maxim Vialkov, Abdel Rebii, Mengjiao Xiao, Jing Zhou, P. Chimenti, Jingjing Liang, Yuanyuan Zhang, Pingping Chen, Igor Tkachev, A. Cammi, Oliver Pilarczyk, Vit Vorobel, Zhimin Wang, Honghao Zhang, Zhenxiong Yuan, Xiang Zhou, Damien Dornic, Jie Zhang, Zhangquan Xie, Yaping Cheng, Ying Yuan, Maxim Gonchar, Wei Wei, Zhuojun Hu, Ivano Lippi, Xilei Sun, Shaomin Chen, Jun Cao, Li Zhou, Ruiguang Wang, Nikolay Anfimov, Andrea Triossi, Runxuan Liu, Xinglong Li, Waseem Khan, Pasi Kuusiniemi, Xi Wang, Salvatore Monforte, Meihang Xu, Eric Baussan, Haifeng Yao, Xuantong Zhang, Yang Han, Pascal Poussot, Dongmei Xia, Jacky Schuler, Hao Qiao, Hu Liu, Henning Rebber, Dmitry V. Naumov, Luca Stanco, Paul Hackspacher, Y. K. Hor, Lei Fan, Ziyan Deng, Lei Huo, Ondrej Sramek, K. J. Li, Jianglai Liu, Lu Wang, Paolo Lombardi, Marcos Dracos, B. Roskovec, Taras Rezinko, Quan Tang, Jiawei Deng, Jason Leung, Xiao Tang, Junji Jia, Huiling Li, Nunzio Guardone, Chuanya Cao, Diana Navas-Nicolas, A. Meregaglia, Zhi-zhong Xing, V. Fekete, Jilei Xu, W. Wang, Siguang Wang, Yupeng Yan, Hao Cai, Christopher Wiebusch, Y. B. Hsiung, Z. V. Krumshteyn, Sirichok Jungthawan, Thiago Sogo-Bezerra, Yury Malyshkin, S. Li, Dmitry Fedoseev, Tao Lin, Chuan Lu, J. F. Chang, Davide Chiesa, Changgen Yang, A. Garfagnini, F. Perrot, Wilfried Depnering, Xiaoyan Ma, Yadong Wei, M. Wang, O. Gorchakov, Yajun Mao, Anguo Peng, C. Cerna, Wei He, Lothar Oberauer, Konstantin Stankevich, Yuri Gornushkin, Donghua Fan, Cong Guo, Dušan Štefánik, Ming Qi, Lianghong Wei, Jihane Maalmi, E. Naumova, Jaruchit Siripak, Tadeas Dohnal, Julia Sawatzki, Hongbang Liu, X. R. Chen, Bjoern Wonsak, Vladimir Lyashuk, Johannes van den Boom, Qinhua Huang, Jingyuan Guo, Yuda Zeng, Shulin Liu, Tao Zhang, Guo-Li Wang, Hui Gong, Michaela Schever, Jun Hu, K. J. Zhu, P. W. Luo, Shun Zhou, Bin Ren, Nan Zhou, Yan Liu, Li Kang, Junguang Lu, Gioacchino Ranucci, Chiye Yu, Cheng Xu, Hongzhao Yu, Hanxiong Huang, Xiongbo Yan, Sai-Juan Chen, C. Volpe, Hiroshi Nunokawa, Yanchu Wang, Vladislav Sharov, Xiaoshan Jiang, Abusleme, A, Adam, T, Ahmad, S, Ahmed, R, Aiello, S, Akram, M, An, F, An, G, An, Q, Andronico, G, Anfimov, N, Antonelli, V, Antoshkina, T, Asavapibhop, B, de Andre, J, Auguste, D, Babic, A, Baldini, W, Barresi, A, Baussan, E, Bellato, M, Bergnoli, A, Bernieri, E, Birkenfeld, T, Blin, S, Blum, D, Blyth, S, Bolshakova, A, Bongrand, M, Bordereau, C, Breton, D, Brigatti, A, Brugnera, R, Bruno, R, Budano, A, Buscemi, M, Busto, J, Butorov, I, Cabrera, A, Cai, H, Cai, X, Cai, Y, Cai, Z, Cammi, A, Campeny, A, Cao, C, Cao, G, Cao, J, Caruso, R, Cerna, C, Chang, J, Chang, Y, Chen, P, Chen, S, Chen, X, Chen, Y, Chen, Z, Cheng, J, Cheng, Y, Chiesa, D, Chimenti, P, Chukanov, A, Chuvashova, A, Claverie, G, Clementi, C, Clerbaux, B, Lorenzo, S, Corti, D, Costa, S, Corso, F, Dalager, O, Taille, C, Deng, J, Deng, Z, Depnering, W, Diaz, M, Ding, X, Ding, Y, Dirgantara, B, Dmitrievsky, S, Dohnal, T, Donchenko, G, Dong, J, Dornic, D, Doroshkevich, E, Dracos, M, Druillole, F, Du, S, Dusini, S, Dvorak, M, Enqvist, T, Enzmann, H, Fabbri, A, Fajt, L, Fan, D, Fan, L, Fang, C, Fang, J, Fargetta, M, Fatkina, A, Fedoseev, D, Fekete, V, Feng, L, Feng, Q, Ford, R, Formozov, A, Fournier, A, Gan, H, Gao, F, Garfagnini, A, Gottel, A, Genster, C, Giammarchi, M, Giaz, A, Giudice, N, Giuliani, F, Gonchar, M, Gong, G, Gong, H, Gorchakov, O, Gornushkin, Y, Grassi, M, Grewing, C, Gromov, V, Gu, M, Gu, X, Gu, Y, Guan, M, Guardone, N, Gul, M, Guo, C, Guo, J, Guo, W, Guo, X, Guo, Y, Hackspacher, P, Hagner, C, Han, R, Han, Y, Hassan, M, He, M, He, W, Heinz, T, Hellmuth, P, Heng, Y, Herrera, R, Hong, D, Hor, Y, Hou, S, Hsiung, Y, Hu, B, Hu, H, Hu, J, Hu, S, Hu, T, Hu, Z, Huang, C, Huang, G, Huang, H, Huang, Q, Huang, W, Huang, X, Huang, Y, Hui, J, Huo, L, Huo, W, Huss, C, Hussain, S, Insolia, A, Ioannisian, A, Isocrate, R, Jelmini, B, Jen, K, Ji, X, Jia, H, Jia, J, Jian, S, Jiang, D, Jiang, X, Jin, R, Jing, X, Jollet, C, Joutsenvaara, J, Jungthawan, S, Kalousis, L, Kampmann, P, Kang, L, Karagounis, M, Kazarian, N, Khan, A, Khan, W, Khosonthongkee, K, Kinz, P, Korablev, D, Kouzakov, K, Krasnoperov, A, Krokhaleva, S, Krumshteyn, Z, Kruth, A, Kutovskiy, N, Kuusiniemi, P, Lachenmaier, T, Landini, C, Leblanc, S, Lebrin, V, Lefevre, F, Lei, R, Leitner, R, Leung, J, Li, D, Li, F, Li, H, Li, J, Li, K, Li, M, Li, N, Li, Q, Li, R, Li, S, Li, T, Li, W, Li, X, Li, Y, Li, Z, Liang, H, Liang, J, Liebau, D, Limphirat, A, Limpijumnong, S, Lin, G, Lin, S, Lin, T, Ling, J, Lippi, I, Liu, F, Liu, H, Liu, J, Liu, M, Liu, Q, Liu, R, Liu, S, Liu, X, Liu, Y, Lokhov, A, Lombardi, P, Lombardo, C, Loo, K, Lu, C, Lu, H, Lu, J, Lu, S, Lu, X, Lubsandorzhiev, B, Lubsandorzhiev, S, Ludhova, L, Luo, F, Luo, G, Luo, P, Luo, S, Luo, W, Lyashuk, V, Ma, Q, Ma, S, Ma, X, Maalmi, J, Malyshkin, Y, Mantovani, F, Manzali, F, Mao, X, Mao, Y, Mari, S, Marini, F, Marium, S, Martellini, C, Martin-Chassard, G, Martini, A, Mayilyan, D, Muller, A, Mednieks, I, Meng, Y, Meregaglia, A, Meroni, E, Meyhofer, D, Mezzetto, M, Miller, J, Miramonti, L, Monforte, S, Montini, P, Montuschi, M, Morozov, N, Muhammad, W, Muralidharan, P, Nastasi, M, Naumov, D, Naumova, E, Navas-Nicolas, D, Nemchenok, I, Ning, F, Ning, Z, Nunokawa, H, Oberauer, L, Ochoa-Ricoux, J, Olshevskiy, A, Orestano, D, Ortica, F, Pan, H, Paoloni, A, Parkalian, N, Parmeggiano, S, Payupol, T, Pei, Y, Pelliccia, N, Peng, A, Peng, H, Perrot, F, Petitjean, P, Petrucci, F, Rico, L, Pilarczyk, O, Popov, A, Poussot, P, Pratumwan, W, Previtali, E, Qi, F, Qi, M, Qian, S, Qian, X, Qiao, H, Qin, Z, Qiu, S, Rajput, M, Ranucci, G, Raper, N, Re, A, Rebber, H, Rebii, A, Ren, B, Ren, J, Rezinko, T, Ricci, B, Robens, M, Roche, M, Rodphai, N, Romani, A, Roskovec, B, Roth, C, Ruan, X, Rujirawat, S, Rybnikov, A, Sadovsky, A, Saggese, P, Salamanna, G, Sanfilippo, S, Sangka, A, Sanguansak, N, Sawangwit, U, Sawatzki, J, Sawy, F, Schever, M, Schuler, J, Schwab, C, Schweizer, K, Selivanov, D, Selyunin, A, Serafini, A, Settanta, G, Settimo, M, Shao, Z, Sharov, V, Shi, J, Shutov, V, Sidorenkov, A, Simkovic, F, Sirignano, C, Siripak, J, Sisti, M, Slupecki, M, Smirnov, M, Smirnov, O, Sogo-Bezerra, T, Songwadhana, J, Soonthornthum, B, Sotnikov, A, Sramek, O, Sreethawong, W, Stahl, A, Stanco, L, Stankevich, K, Stefanik, D, Steiger, H, Steinmann, J, Sterr, T, Stock, M, Strati, V, Studenikin, A, Sun, G, Sun, S, Sun, X, Sun, Y, Suwonjandee, N, Szelezniak, M, Tang, J, Tang, Q, Tang, X, Tietzsch, A, Tkachev, I, Tmej, T, Treskov, K, Triossi, A, Troni, G, Trzaska, W, Tuve, C, van Waasen, S, van den Boom, J, Vanroyen, G, Vassilopoulos, N, Vedin, V, Verde, G, Vialkov, M, Viaud, B, Volpe, C, Vorobel, V, Votano, L, Walker, P, Wang, C, Wang, E, Wang, G, Wang, J, Wang, K, Wang, L, Wang, M, Wang, R, Wang, S, Wang, W, Wang, X, Wang, Y, Wang, Z, Watcharangkool, A, Wei, L, Wei, W, Wei, Y, Wen, L, Wiebusch, C, Wong, S, Wonsak, B, Wu, D, Wu, F, Wu, Q, Wu, W, Wu, Z, Wurm, M, Wurtz, J, Wysotzki, C, Xi, Y, Xia, D, Xiao, M, Xie, Y, Xie, Z, Xing, Z, Xu, B, Xu, C, Xu, D, Xu, F, Xu, J, Xu, M, Xu, Y, Yan, B, Yan, X, Yan, Y, Yang, A, Yang, C, Yang, H, Yang, J, Yang, L, Yang, X, Yang, Y, Yao, H, Yasin, Z, Ye, J, Ye, M, Ye, Z, Yegin, U, Yermia, F, Yi, P, Yin, X, You, Z, Yu, B, Yu, C, Yu, H, Yu, M, Yu, X, Yu, Z, Yuan, C, Yuan, Y, Yuan, Z, Yue, B, Zafar, N, Zambanini, A, Zeng, S, Zeng, T, Zeng, Y, Zhan, L, Zhang, F, Zhang, G, Zhang, H, Zhang, J, Zhang, P, Zhang, Q, Zhang, S, Zhang, T, Zhang, X, Zhang, Y, Zhang, Z, Zhao, F, Zhao, J, Zhao, R, Zhao, S, Zhao, T, Zheng, D, Zheng, H, Zheng, M, Zheng, Y, Zhong, W, Zhou, J, Zhou, L, Zhou, N, Zhou, S, Zhou, X, Zhu, J, Zhu, K, Zhuang, H, Zong, L, Zou, J, Institut Pluridisciplinaire Hubert Curien (IPHC), Institut National de Physique Nucléaire et de Physique des Particules du CNRS (IN2P3)-Université de Strasbourg (UNISTRA)-Centre National de la Recherche Scientifique (CNRS), Laboratoire de Physique des 2 Infinis Irène Joliot-Curie (IJCLab), Institut National de Physique Nucléaire et de Physique des Particules du CNRS (IN2P3)-Université Paris-Saclay-Centre National de la Recherche Scientifique (CNRS), Laboratoire de physique subatomique et des technologies associées (SUBATECH), Université de Nantes - UFR des Sciences et des Techniques (UN UFR ST), Université de Nantes (UN)-Université de Nantes (UN)-Centre National de la Recherche Scientifique (CNRS)-Institut National de Physique Nucléaire et de Physique des Particules du CNRS (IN2P3)-IMT Atlantique Bretagne-Pays de la Loire (IMT Atlantique), Institut Mines-Télécom [Paris] (IMT)-Institut Mines-Télécom [Paris] (IMT), Centre d'Etudes Nucléaires de Bordeaux Gradignan (CENBG), Université Sciences et Technologies - Bordeaux 1-Institut National de Physique Nucléaire et de Physique des Particules du CNRS (IN2P3)-Centre National de la Recherche Scientifique (CNRS), Centre de Physique des Particules de Marseille (CPPM), Aix Marseille Université (AMU)-Institut National de Physique Nucléaire et de Physique des Particules du CNRS (IN2P3)-Centre National de la Recherche Scientifique (CNRS), JUNO, Université de Strasbourg (UNISTRA)-Université de Haute-Alsace (UHA) Mulhouse - Colmar (Université de Haute-Alsace (UHA))-Institut National de Physique Nucléaire et de Physique des Particules du CNRS (IN2P3)-Centre National de la Recherche Scientifique (CNRS), Institut National de Physique Nucléaire et de Physique des Particules du CNRS (IN2P3)-Centre National de la Recherche Scientifique (CNRS)-IMT Atlantique (IMT Atlantique), Institut Mines-Télécom [Paris] (IMT)-Institut Mines-Télécom [Paris] (IMT)-Nantes université - UFR des Sciences et des Techniques (Nantes univ - UFR ST), Nantes Université - pôle Sciences et technologie, Nantes Université (Nantes Univ)-Nantes Université (Nantes Univ)-Nantes Université - pôle Sciences et technologie, Nantes Université (Nantes Univ)-Nantes Université (Nantes Univ), Université Sciences et Technologies - Bordeaux 1 (UB)-Institut National de Physique Nucléaire et de Physique des Particules du CNRS (IN2P3)-Centre National de la Recherche Scientifique (CNRS), Abusleme A., Adam T., Ahmad S., Ahmed R., Aiello S., Akram M., An F., An G., An Q., Andronico G., Anfimov N., Antonelli V., Antoshkina T., Asavapibhop B., de Andre J.P.A.M., Auguste D., Babic A., Baldini W., Barresi A., Baussan E., Bellato M., Bergnoli A., Bernieri E., Birkenfeld T., Blin S., Blum D., Blyth S., Bolshakova A., Bongrand M., Bordereau C., Breton D., Brigatti A., Brugnera R., Bruno R., Budano A., Buscemi M., Busto J., Butorov I., Cabrera A., Cai H., Cai X., Cai Y., Cai Z., Cammi A., Campeny A., Cao C., Cao G., Cao J., Caruso R., Cerna C., Chang J., Chang Y., Chen P., Chen P.-A., Chen S., Chen X., Chen Y.-W., Chen Y., Chen Z., Cheng J., Cheng Y., Chiesa D., Chimenti P., Chukanov A., Chuvashova A., Claverie G., Clementi C., Clerbaux B., Lorenzo S.C.D., Corti D., Costa S., Corso F.D., Dalager O., Taille C.D.L., Deng J., Deng Z., Depnering W., Diaz M., Ding X., Ding Y., Dirgantara B., Dmitrievsky S., Dohnal T., Donchenko G., Dong J., Dornic D., Doroshkevich E., Dracos M., Druillole F., Du S., Dusini S., Dvorak M., Enqvist T., Enzmann H., Fabbri A., Fajt L., Fan D., Fan L., Fang C., Fang J., Fargetta M., Fatkina A., Fedoseev D., Fekete V., Feng L.-C., Feng Q., Ford R., Formozov A., Fournier A., Gan H., Gao F., Garfagnini A., Gottel A., Genster C., Giammarchi M., Giaz A., Giudice N., Giuliani F., Gonchar M., Gong G., Gong H., Gorchakov O., Gornushkin Y., Grassi M., Grewing C., Gromov V., Gu M., Gu X., Gu Y., Guan M., Guardone N., Gul M., Guo C., Guo J., Guo W., Guo X., Guo Y., Hackspacher P., Hagner C., Han R., Han Y., Hassan M., He M., He W., Heinz T., Hellmuth P., Heng Y., Herrera R., Hong D., Hor Y., Hou S., Hsiung Y., Hu B.-Z., Hu H., Hu J., Hu S., Hu T., Hu Z., Huang C., Huang G., Huang H., Huang Q., Huang W., Huang X., Huang Y., Hui J., Huo L., Huo W., Huss C., Hussain S., Insolia A., Ioannisian A., Isocrate R., Jelmini B., Jen K.-L., Ji X., Jia H., Jia J., Jian S., Jiang D., Jiang X., Jin R., Jing X., Jollet C., Joutsenvaara J., Jungthawan S., Kalousis L., Kampmann P., Kang L., Karagounis M., Kazarian N., Khan A., Khan W., Khosonthongkee K., Kinz P., Korablev D., Kouzakov K., Krasnoperov A., Krokhaleva S., Krumshteyn Z., Kruth A., Kutovskiy N., Kuusiniemi P., Lachenmaier T., Landini C., Leblanc S., Lebrin V., Lefevre F., Lei R., Leitner R., Leung J., Li D., Li F., Li H., Li J., Li K., Li M., Li N., Li Q., Li R., Li S., Li T., Li W., Li X., Li Y., Li Z., Liang H., Liang J., Liebau D., Limphirat A., Limpijumnong S., Lin G.-L., Lin S., Lin T., Ling J., Lippi I., Liu F., Liu H., Liu J., Liu M., Liu Q., Liu R., Liu S., Liu X., Liu Y., Lokhov A., Lombardi P., Lombardo C., Loo K., Lu C., Lu H., Lu J., Lu S., Lu X., Lubsandorzhiev B., Lubsandorzhiev S., Ludhova L., Luo F., Luo G., Luo P., Luo S., Luo W., Lyashuk V., Ma Q., Ma S., Ma X., Maalmi J., Malyshkin Y., Mantovani F., Manzali F., Mao X., Mao Y., Mari S.M., Marini F., Marium S., Martellini C., Martin-Chassard G., Martini A., Mayilyan D., Muller A., Mednieks I., Meng Y., Meregaglia A., Meroni E., Meyhofer D., Mezzetto M., Miller J., Miramonti L., Monforte S., Montini P., Montuschi M., Morozov N., Muhammad W., Muralidharan P., Nastasi M., Naumov D.V., Naumova E., Navas-Nicolas D., Nemchenok I., Ning F., Ning Z., Nunokawa H., Oberauer L., Ochoa-Ricoux J.P., Olshevskiy A., Orestano D., Ortica F., Pan H.-R., Paoloni A., Parkalian N., Parmeggiano S., Payupol T., Pei Y., Pelliccia N., Peng A., Peng H., Perrot F., Petitjean P.-A., Petrucci F., Rico L.F.P., Pilarczyk O., Popov A., Poussot P., Pratumwan W., Previtali E., Qi F., Qi M., Qian S., Qian X., Qiao H., Qin Z., Qiu S., Rajput M., Ranucci G., Raper N., Re A., Rebber H., Rebii A., Ren B., Ren J., Rezinko T., Ricci B., Robens M., Roche M., Rodphai N., Romani A., Roskovec B., Roth C., Ruan X., Rujirawat S., Rybnikov A., Sadovsky A., Saggese P., Salamanna G., Sanfilippo S., Sangka A., Sanguansak N., Sawangwit U., Sawatzki J., Sawy F., Schever M., Schuler J., Schwab C., Schweizer K., Selivanov D., Selyunin A., Serafini A., Settanta G., Settimo M., Shao Z., Sharov V., Shi J., Shutov V., Sidorenkov A., Simkovic F., Sirignano C., Siripak J., Sisti M., Slupecki M., Smirnov M., Smirnov O., Sogo-Bezerra T., Songwadhana J., Soonthornthum B., Sotnikov A., Sramek O., Sreethawong W., Stahl A., Stanco L., Stankevich K., Stefanik D., Steiger H., Steinmann J., Sterr T., Stock M.R., Strati V., Studenikin A., Sun G., Sun S., Sun X., Sun Y., Suwonjandee N., Szelezniak M., Tang J., Tang Q., Tang X., Tietzsch A., Tkachev I., Tmej T., Treskov K., Triossi A., Troni G., Trzaska W., Tuve C., van Waasen S., van den Boom J., Vanroyen G., Vassilopoulos N., Vedin V., Verde G., Vialkov M., Viaud B., Volpe C., Vorobel V., Votano L., Walker P., Wang C., Wang C.-H., Wang E., Wang G., Wang J., Wang K., Wang L., Wang M., Wang R., Wang S., Wang W., Wang X., Wang Y., Wang Z., Watcharangkool A., Wei L., Wei W., Wei Y., Wen L., Wiebusch C., Wong S.C.-F., Wonsak B., Wu D., Wu F., Wu Q., Wu W., Wu Z., Wurm M., Wurtz J., Wysotzki C., Xi Y., Xia D., Xiao M., Xie Y., Xie Z., Xing Z., Xu B., Xu C., Xu D., Xu F., Xu J., Xu M., Xu Y., Yan B., Yan X., Yan Y., Yang A., Yang C., Yang H., Yang J., Yang L., Yang X., Yang Y., Yao H., Yasin Z., Ye J., Ye M., Ye Z., Yegin U., Yermia F., Yi P., Yin X., You Z., Yu B., Yu C., Yu H., Yu M., Yu X., Yu Z., Yuan C., Yuan Y., Yuan Z., Yue B., Zafar N., Zambanini A., Zeng S., Zeng T., Zeng Y., Zhan L., Zhang F., Zhang G., Zhang H., Zhang J., Zhang P., Zhang Q., Zhang S., Zhang T., Zhang X., Zhang Y., Zhang Z., Zhao F., Zhao J., Zhao R., Zhao S., Zhao T., Zheng D., Zheng H., Zheng M., Zheng Y., Zhong W., Zhou J., Zhou L., Zhou N., Zhou S., Zhou X., Zhu J., Zhu K., Zhuang H., Zong L., Zou J., Abusleme, A., Adam, T., Ahmad, S., Ahmed, R., Aiello, S., Akram, M., An, F., An, G., An, Q., Andronico, G., Anfimov, N., Antonelli, V., Antoshkina, T., Asavapibhop, B., de Andre, J. P. A. M., Auguste, D., Babic, A., Baldini, W., Barresi, A., Baussan, E., Bellato, M., Bergnoli, A., Bernieri, E., Birkenfeld, T., Blin, S., Blum, D., Blyth, S., Bolshakova, A., Bongrand, M., Bordereau, C., Breton, D., Brigatti, A., Brugnera, R., Bruno, R., Budano, A., Buscemi, M., Busto, J., Butorov, I., Cabrera, A., Cai, H., Cai, X., Cai, Y., Cai, Z., Cammi, A., Campeny, A., Cao, C., Cao, G., Cao, J., Caruso, R., Cerna, C., Chang, J., Chang, Y., Chen, P., Chen, P. -A., Chen, S., Chen, X., Chen, Y. -W., Chen, Y., Chen, Z., Cheng, J., Cheng, Y., Chiesa, D., Chimenti, P., Chukanov, A., Chuvashova, A., Claverie, G., Clementi, C., Clerbaux, B., Lorenzo, S. C. D., Corti, D., Costa, S., Corso, F. D., Dalager, O., Taille, C. D. L., Deng, J., Deng, Z., Depnering, W., Diaz, M., Ding, X., Ding, Y., Dirgantara, B., Dmitrievsky, S., Dohnal, T., Donchenko, G., Dong, J., Dornic, D., Doroshkevich, E., Dracos, M., Druillole, F., Du, S., Dusini, S., Dvorak, M., Enqvist, T., Enzmann, H., Fabbri, A., Fajt, L., Fan, D., Fan, L., Fang, C., Fang, J., Fargetta, M., Fatkina, A., Fedoseev, D., Fekete, V., Feng, L. -C., Feng, Q., Ford, R., Formozov, A., Fournier, A., Gan, H., Gao, F., Garfagnini, A., Gottel, A., Genster, C., Giammarchi, M., Giaz, A., Giudice, N., Giuliani, F., Gonchar, M., Gong, G., Gong, H., Gorchakov, O., Gornushkin, Y., Grassi, M., Grewing, C., Gromov, V., Gu, M., Gu, X., Gu, Y., Guan, M., Guardone, N., Gul, M., Guo, C., Guo, J., Guo, W., Guo, X., Guo, Y., Hackspacher, P., Hagner, C., Han, R., Han, Y., Hassan, M., He, M., He, W., Heinz, T., Hellmuth, P., Heng, Y., Herrera, R., Hong, D., Hor, Y., Hou, S., Hsiung, Y., Hu, B. -Z., Hu, H., Hu, J., Hu, S., Hu, T., Hu, Z., Huang, C., Huang, G., Huang, H., Huang, Q., Huang, W., Huang, X., Huang, Y., Hui, J., Huo, L., Huo, W., Huss, C., Hussain, S., Insolia, A., Ioannisian, A., Isocrate, R., Jelmini, B., Jen, K. -L., Ji, X., Jia, H., Jia, J., Jian, S., Jiang, D., Jiang, X., Jin, R., Jing, X., Jollet, C., Joutsenvaara, J., Jungthawan, S., Kalousis, L., Kampmann, P., Kang, L., Karagounis, M., Kazarian, N., Khan, A., Khan, W., Khosonthongkee, K., Kinz, P., Korablev, D., Kouzakov, K., Krasnoperov, A., Krokhaleva, S., Krumshteyn, Z., Kruth, A., Kutovskiy, N., Kuusiniemi, P., Lachenmaier, T., Landini, C., Leblanc, S., Lebrin, V., Lefevre, F., Lei, R., Leitner, R., Leung, J., Li, D., Li, F., Li, H., Li, J., Li, K., Li, M., Li, N., Li, Q., Li, R., Li, S., Li, T., Li, W., Li, X., Li, Y., Li, Z., Liang, H., Liang, J., Liebau, D., Limphirat, A., Limpijumnong, S., Lin, G. -L., Lin, S., Lin, T., Ling, J., Lippi, I., Liu, F., Liu, H., Liu, J., Liu, M., Liu, Q., Liu, R., Liu, S., Liu, X., Liu, Y., Lokhov, A., Lombardi, P., Lombardo, C., Loo, K., Lu, C., Lu, H., Lu, J., Lu, S., Lu, X., Lubsandorzhiev, B., Lubsandorzhiev, S., Ludhova, L., Luo, F., Luo, G., Luo, P., Luo, S., Luo, W., Lyashuk, V., Ma, Q., Ma, S., Ma, X., Maalmi, J., Malyshkin, Y., Mantovani, F., Manzali, F., Mao, X., Mao, Y., Mari, S. M., Marini, F., Marium, S., Martellini, C., Martin-Chassard, G., Martini, A., Mayilyan, D., Muller, A., Mednieks, I., Meng, Y., Meregaglia, A., Meroni, E., Meyhofer, D., Mezzetto, M., Miller, J., Miramonti, L., Monforte, S., Montini, P., Montuschi, M., Morozov, N., Muhammad, W., Muralidharan, P., Nastasi, M., Naumov, D. V., Naumova, E., Navas-Nicolas, D., Nemchenok, I., Ning, F., Ning, Z., Nunokawa, H., Oberauer, L., Ochoa-Ricoux, J. P., Olshevskiy, A., Orestano, D., Ortica, F., Pan, H. -R., Paoloni, A., Parkalian, N., Parmeggiano, S., Payupol, T., Pei, Y., Pelliccia, N., Peng, A., Peng, H., Perrot, F., Petitjean, P. -A., Petrucci, F., Rico, L. F. 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Subjects: Nuclear and High Energy Physics, Physics - Instrumentation and Detectors, Physics::Instrumentation and Detectors, measurement methods, scintillation counter: liquid, energy resolution, FOS: Physical sciences, Photodetector, Scintillator, 01 natural sciences, NO, High Energy Physics - Experiment, High Energy Physics - Experiment (hep-ex), hal-03022811, PE2_2, Optics, 0103 physical sciences, [PHYS.HEXP]Physics [physics]/High Energy Physics - Experiment [hep-ex], Calibration, lcsh:Nuclear and particle physics. Atomic energy. Radioactivity, ddc:530, [PHYS.PHYS.PHYS-INS-DET]Physics [physics]/Physics [physics]/Instrumentation and Detectors [physics.ins-det], 010306 general physics, Astrophysique, Jiangmen Underground Neutrino Observatory, Physics, JUNO, liquid [scintillation counter], 010308 nuclear & particles physics, business.industry, Settore FIS/01 - Fisica Sperimentale, Detector, Astrophysics::Instrumentation and Methods for Astrophysics, Linearity, Instrumentation and Detectors (physics.ins-det), calibration, Neutrino Detectors and Telescopes (experiments), lcsh:QC770-798, High Energy Physics::Experiment, Neutrino, business, Energy (signal processing)
Abstract: We present the calibration strategy for the 20 kton liquid scintillator central detector of the Jiangmen Underground Neutrino Observatory (JUNO). By utilizing a comprehensive multiple-source and multiple-positional calibration program, in combination with a novel dual calorimetry technique exploiting two independent photosensors and readout systems, we demonstrate that the JUNO central detector can achieve a better than 1% energy linearity and a 3% effective energy resolution, required by the neutrino mass ordering determination. [Figure not available: see fulltext.], 0, info:eu-repo/semantics/published
Published: 2021

6. Radioactivity control strategy for the JUNO detector

Author: The JUNO collaboration, Angel Abusleme, Thomas Adam, Shakeel Ahmad, Rizwan Ahmed, Sebastiano Aiello, Muhammad Akram, Fengpeng An, Qi An, Giuseppe Andronico, Nikolay Anfimov, Vito Antonelli, Tatiana Antoshkina, Burin Asavapibhop, João Pedro Athayde Marcondes de André, Didier Auguste, Andrej Babic, Wander Baldini, Andrea Barresi, Davide Basilico, Eric Baussan, Marco Bellato, Antonio Bergnoli, Thilo Birkenfeld, Sylvie Blin, David Blum, Simon Blyth, Anastasia Bolshakova, Mathieu Bongrand, Clément Bordereau, Dominique Breton, Augusto Brigatti, Riccardo Brugnera, Riccardo Bruno, Antonio Budano, Mario Buscemi, Jose Busto, Ilya Butorov, Anatael Cabrera, Hao Cai, Xiao Cai, Yanke Cai, Zhiyan Cai, Antonio Cammi, Agustin Campeny, Chuanya Cao, Guofu Cao, Jun Cao, Rossella Caruso, Cédric Cerna, Jinfan Chang, Yun Chang, Pingping Chen, Po-An Chen, Shaomin Chen, Xurong Chen, Yi-Wen Chen, Yixue Chen, Yu Chen, Zhang Chen, Jie Cheng, Yaping Cheng, Alexey Chetverikov, Davide Chiesa, Pietro Chimenti, Artem Chukanov, Gérard Claverie, Catia Clementi, Barbara Clerbaux, Selma Conforti Di Lorenzo, Daniele Corti, Oliviero Cremonesi, Flavio Dal Corso, Olivia Dalager, Christophe De La Taille, Jiawei Deng, Zhi Deng, Ziyan Deng, Wilfried Depnering, Marco Diaz, Xuefeng Ding, Yayun Ding, Bayu Dirgantara, Sergey Dmitrievsky, Tadeas Dohnal, Dmitry Dolzhikov, Georgy Donchenko, Jianmeng Dong, Evgeny Doroshkevich, Marcos Dracos, Frédéric Druillole, Shuxian Du, Stefano Dusini, Martin Dvorak, Timo Enqvist, Heike Enzmann, Andrea Fabbri, Lukas Fajt, Donghua Fan, Lei Fan, Jian Fang, Wenxing Fang, Marco Fargetta, Dmitry Fedoseev, Vladko Fekete, Li-Cheng Feng, Qichun Feng, Richard Ford, Andrey Formozov, Amélie Fournier, Haonan Gan, Feng Gao, Alberto Garfagnini, Marco Giammarchi, Agnese Giaz, Nunzio Giudice, Maxim Gonchar, Guanghua Gong, Hui Gong, Yuri Gornushkin, Alexandre Göttel, Marco Grassi, Christian Grewing, Vasily Gromov, Minghao Gu, Xiaofei Gu, Yu Gu, Mengyun Guan, Nunzio Guardone, Maria Gul, Cong Guo, Jingyuan Guo, Wanlei Guo, Xinheng Guo, Yuhang Guo, Paul Hackspacher, Caren Hagner, Ran Han, Yang Han, Muhammad Sohaib Hassan, Miao He, Wei He, Tobias Heinz, Patrick Hellmuth, Yuekun Heng, Rafael Herrera, YuenKeung Hor, Shaojing Hou, Yee Hsiung, Bei-Zhen Hu, Hang Hu, Jianrun Hu, Jun Hu, Shouyang Hu, Tao Hu, Zhuojun Hu, Chunhao Huang, Guihong Huang, Hanxiong Huang, Wenhao Huang, Xin Huang, Xingtao Huang, Yongbo Huang, Jiaqi Hui, Lei Huo, Wenju Huo, Cédric Huss, Safeer Hussain, Ara Ioannisian, Roberto Isocrate, Beatrice Jelmini, Kuo-Lun Jen, Ignacio Jeria, Xiaolu Ji, Xingzhao Ji, Huihui Jia, Junji Jia, Siyu Jian, Di Jiang, Xiaoshan Jiang, Ruyi Jin, Xiaoping Jing, Cécile Jollet, Jari Joutsenvaara, Sirichok Jungthawan, Leonidas Kalousis, Philipp Kampmann, Li Kang, Rebin Karaparambil, Narine Kazarian, Waseem Khan, Khanchai Khosonthongkee, Denis Korablev, Konstantin Kouzakov, Alexey Krasnoperov, Andre Kruth, Nikolay Kutovskiy, Pasi Kuusiniemi, Tobias Lachenmaier, Cecilia Landini, Sébastien Leblanc, Victor Lebrin, Frederic Lefevre, Ruiting Lei, Rupert Leitner, Jason Leung, Demin Li, Fei Li, Fule Li, Haitao Li, Huiling Li, Jiaqi Li, Mengzhao Li, Min Li, Nan Li, Qingjiang Li, Ruhui Li, Shanfeng Li, Tao Li, Weidong Li, Weiguo Li, Xiaomei Li, Xiaonan Li, Xinglong Li, Yi Li, Yufeng Li, Zhaohan Li, Zhibing Li, Ziyuan Li, Hao Liang, Jiajun Liao, Daniel Liebau, Ayut Limphirat, Sukit Limpijumnong, Guey-Lin Lin, Shengxin Lin, Tao Lin, Jiajie Ling, Ivano Lippi, Fang Liu, Haidong Liu, Hongbang Liu, Hongjuan Liu, Hongtao Liu, Hui Liu, Jianglai Liu, Jinchang Liu, Min Liu, Qian Liu, Qin Liu, Runxuan Liu, Shuangyu Liu, Shubin Liu, Shulin Liu, Xiaowei Liu, Xiwen Liu, Yan Liu, Yunzhe Liu, Alexey Lokhov, Paolo Lombardi, Claudio Lombardo, Kai Loo, Chuan Lu, Haoqi Lu, Jingbin Lu, Junguang Lu, Shuxiang Lu, Xiaoxu Lu, Bayarto Lubsandorzhiev, Sultim Lubsandorzhiev, Livia Ludhova, Fengjiao Luo, Guang Luo, Pengwei Luo, Shu Luo, Wuming Luo, Vladimir Lyashuk, Bangzheng Ma, Qiumei Ma, Si Ma, Xiaoyan Ma, Xubo Ma, Jihane Maalmi, Yury Malyshkin, Fabio Mantovani, Francesco Manzali, Xin Mao, Yajun Mao, Stefano M. Mari, Filippo Marini, Sadia Marium, Cristina Martellini, Gisele Martin-Chassard, Agnese Martini, Matthias Mayer, Davit Mayilyan, Ints Mednieks, Yue Meng, Anselmo Meregaglia, Emanuela Meroni, David Meyhöfer, Mauro Mezzetto, Jonathan Miller, Lino Miramonti, Paolo Montini, Michele Montuschi, Axel Müller, Massimiliano Nastasi, Dmitry V. Naumov, Elena Naumova, Diana Navas-Nicolas, Igor Nemchenok, Minh Thuan Nguyen Thi, Feipeng Ning, Zhe Ning, Hiroshi Nunokawa, Lothar Oberauer, Juan Pedro Ochoa-Ricoux, Alexander Olshevskiy, Domizia Orestano, Fausto Ortica, Rainer Othegraven, Hsiao-Ru Pan, Alessandro Paoloni, Sergio Parmeggiano, Yatian Pei, Nicomede Pelliccia, Anguo Peng, Haiping Peng, Frédéric Perrot, Pierre-Alexandre Petitjean, Fabrizio Petrucci, Oliver Pilarczyk, Luis Felipe Piñeres Rico, Artyom Popov, Pascal Poussot, Wathan Pratumwan, Ezio Previtali, Fazhi Qi, Ming Qi, Sen Qian, Xiaohui Qian, Zhen Qian, Hao Qiao, Zhonghua Qin, Shoukang Qiu, Muhammad Usman Rajput, Gioacchino Ranucci, Neill Raper, Alessandra Re, Henning Rebber, Abdel Rebii, Bin Ren, Jie Ren, Barbara Ricci, Markus Robens, Mathieu Roche, Narongkiat Rodphai, Aldo Romani, Bedřich Roskovec, Christian Roth, Xiangdong Ruan, Xichao Ruan, Saroj Rujirawat, Arseniy Rybnikov, Andrey Sadovsky, Paolo Saggese, Simone Sanfilippo, Anut Sangka, Nuanwan Sanguansak, Utane Sawangwit, Julia Sawatzki, Fatma Sawy, Michaela Schever, Cédric Schwab, Konstantin Schweizer, Alexandr Selyunin, Andrea Serafini, Giulio Settanta, Mariangela Settimo, Zhuang Shao, Vladislav Sharov, Arina Shaydurova, Jingyan Shi, Yanan Shi, Vitaly Shutov, Andrey Sidorenkov, Fedor Šimkovic, Chiara Sirignano, Jaruchit Siripak, Monica Sisti, Maciej Slupecki, Mikhail Smirnov, Oleg Smirnov, Thiago Sogo-Bezerra, Sergey Sokolov, Julanan Songwadhana, Boonrucksar Soonthornthum, Albert Sotnikov, Ondřej Šrámek, Warintorn Sreethawong, Achim Stahl, Luca Stanco, Konstantin Stankevich, Dušan Štefánik, Hans Steiger, Jochen Steinmann, Tobias Sterr, Matthias Raphael Stock, Virginia Strati, Alexander Studenikin, Shifeng Sun, Xilei Sun, Yongjie Sun, Yongzhao Sun, Narumon Suwonjandee, Michal Szelezniak, Jian Tang, Qiang Tang, Quan Tang, Xiao Tang, Alexander Tietzsch, Igor Tkachev, Tomas Tmej, Konstantin Treskov, Andrea Triossi, Giancarlo Troni, Wladyslaw Trzaska, Cristina Tuve, Nikita Ushakov, Johannes van den Boom, Stefan van Waasen, Guillaume Vanroyen, Nikolaos Vassilopoulos, Vadim Vedin, Giuseppe Verde, Maxim Vialkov, Benoit Viaud, Moritz Cornelius Vollbrecht, Cristina Volpe, Vit Vorobel, Dmitriy Voronin, Lucia Votano, Pablo Walker, Caishen Wang, Chung-Hsiang Wang, En Wang, Guoli Wang, Jian Wang, Jun Wang, Kunyu Wang, Lu Wang, Meifen Wang, Meng Wang, Ruiguang Wang, Siguang Wang, Wei Wang, Wenshuai Wang, Xi Wang, Xiangyue Wang, Yangfu Wang, Yaoguang Wang, Yi Wang, Yifang Wang, Yuanqing Wang, Yuman Wang, Zhe Wang, Zheng Wang, Zhimin Wang, Zongyi Wang, Muhammad Waqas, Apimook Watcharangkool, Lianghong Wei, Wei Wei, Wenlu Wei, Yadong Wei, Liangjian Wen, Christopher Wiebusch, Steven Chan-Fai Wong, Bjoern Wonsak, Diru Wu, Fangliang Wu, Qun Wu, Zhi Wu, Michael Wurm, Jacques Wurtz, Christian Wysotzki, Yufei Xi, Dongmei Xia, Xiaochuan Xie, Yuguang Xie, Zhangquan Xie, Zhizhong Xing, Benda Xu, Cheng Xu, Donglian Xu, Fanrong Xu, Hangkun Xu, Jilei Xu, Jing Xu, Meihang Xu, Yin Xu, Yu Xu, Baojun 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M, Mayilyan, D, Mednieks, I, Meng, Y, Meregaglia, A, Meroni, E, Meyhofer, D, Mezzetto, M, Miller, J, Miramonti, L, Montini, P, Montuschi, M, Muller, A, Nastasi, M, Naumov, D, Naumova, E, Navas-Nicolas, D, Nemchenok, I, Nguyen Thi, M, Ning, F, Ning, Z, Nunokawa, H, Oberauer, L, Ochoa-Ricoux, J, Olshevskiy, A, Orestano, D, Ortica, F, Othegraven, R, Pan, H, Paoloni, A, Parmeggiano, S, Pei, Y, Pelliccia, N, Peng, A, Peng, H, Perrot, F, Petitjean, P, Petrucci, F, Pilarczyk, O, Pineres Rico, L, Popov, A, Poussot, P, Pratumwan, W, Previtali, E, Qi, F, Qi, M, Qian, S, Qian, X, Qian, Z, Qiao, H, Qin, Z, Qiu, S, Rajput, M, Ranucci, G, Raper, N, Re, A, Rebber, H, Rebii, A, Ren, B, Ren, J, Ricci, B, Robens, M, Roche, M, Rodphai, N, Romani, A, Roskovec, B, Roth, C, Ruan, X, Rujirawat, S, Rybnikov, A, Sadovsky, A, Saggese, P, Sanfilippo, S, Sangka, A, Sanguansak, N, Sawangwit, U, Sawatzki, J, Sawy, F, Schever, M, Schwab, C, Schweizer, K, Selyunin, A, Serafini, A, Settanta, G, Settimo, M, Shao, Z, Sharov, V, Shaydurova, A, Shi, J, Shi, Y, Shutov, V, Sidorenkov, A, Simkovic, F, Sirignano, C, Siripak, J, Sisti, M, Slupecki, M, Smirnov, M, Smirnov, O, Sogo-Bezerra, T, Sokolov, S, Songwadhana, J, Soonthornthum, B, Sotnikov, A, Sramek, O, Sreethawong, W, Stahl, A, Stanco, L, Stankevich, K, Stefanik, D, Steiger, H, Steinmann, J, Sterr, T, Stock, M, Strati, V, Studenikin, A, Sun, S, Sun, X, Sun, Y, Suwonjandee, N, Szelezniak, M, Tang, J, Tang, Q, Tang, X, Tietzsch, A, Tkachev, I, Tmej, T, Treskov, K, Triossi, A, Troni, G, Trzaska, W, Tuve, C, Ushakov, N, van den Boom, J, van Waasen, S, Vanroyen, G, Vassilopoulos, N, Vedin, V, Verde, G, Vialkov, M, Viaud, B, Vollbrecht, M, Volpe, C, Vorobel, V, Voronin, D, Votano, L, Walker, P, Wang, C, Wang, E, Wang, G, Wang, J, Wang, K, Wang, L, Wang, M, Wang, R, Wang, S, Wang, W, Wang, X, Wang, Y, Wang, Z, Waqas, M, Watcharangkool, A, Wei, L, Wei, W, Wei, Y, Wen, L, Wiebusch, C, Wong, S, Wonsak, B, Wu, D, Wu, F, Wu, Q, Wu, Z, Wurm, M, Wurtz, J, Wysotzki, C, Xi, Y, Xia, D, Xie, X, Xie, Y, Xie, Z, Xing, Z, Xu, B, Xu, C, Xu, D, Xu, F, Xu, H, Xu, J, Xu, M, Xu, Y, Yan, B, Yan, T, Yan, W, Yan, X, Yan, Y, Yang, A, Yang, C, Yang, H, Yang, J, Yang, L, Yang, X, Yang, Y, Yao, H, Yasin, Z, Ye, J, Ye, M, Ye, Z, Yegin, U, Yermia, F, Yi, P, Yin, N, Yin, X, You, Z, Yu, B, Yu, C, Yu, H, Yu, M, Yu, X, Yu, Z, Yuan, C, Yuan, Y, Yuan, Z, Yue, B, Zafar, N, Zambanini, A, Zavadskyi, V, Zeng, S, Zeng, T, Zeng, Y, Zhan, L, Zhang, A, Zhang, F, Zhang, G, Zhang, H, Zhang, J, Zhang, P, Zhang, Q, Zhang, S, Zhang, T, Zhang, X, Zhang, Y, Zhang, Z, Zhao, F, Zhao, J, Zhao, R, Zhao, S, Zhao, T, Zheng, D, Zheng, H, Zheng, M, Zheng, Y, Zhong, W, Zhou, J, Zhou, L, Zhou, N, Zhou, S, Zhou, T, Zhou, X, Zhu, J, Zhu, K, Zhu, Z, Zhuang, B, Zhuang, H, Zong, L, Zou, J, Abusleme, Angel, Adam, Thoma, Ahmad, Shakeel, Ahmed, Rizwan, Aiello, Sebastiano, Akram, Muhammad, An, Fengpeng, An, Qi, Andronico, Giuseppe, Anfimov, Nikolay, Antonelli, Vito, Antoshkina, Tatiana, Asavapibhop, Burin, de André, João Pedro Athayde Marconde, Auguste, Didier, Babic, Andrej, Baldini, Wander, Barresi, Andrea, Basilico, Davide, Baussan, Eric, Bellato, Marco, Bergnoli, Antonio, Birkenfeld, Thilo, Blin, Sylvie, Blum, David, Blyth, Simon, Bolshakova, Anastasia, Bongrand, Mathieu, Bordereau, Clément, Breton, Dominique, Brigatti, Augusto, Brugnera, Riccardo, Bruno, Riccardo, Budano, Antonio, Buscemi, Mario, Busto, Jose, Butorov, Ilya, Cabrera, Anatael, Cai, Hao, Cai, Xiao, Cai, Yanke, Cai, Zhiyan, Cammi, Antonio, Campeny, Agustin, Cao, Chuanya, Cao, Guofu, Cao, Jun, Caruso, Rossella, Cerna, Cédric, Chang, Jinfan, Chang, Yun, Chen, Pingping, Chen, Po-An, Chen, Shaomin, Chen, Xurong, Chen, Yi-Wen, Chen, Yixue, Chen, Yu, Chen, Zhang, Cheng, Jie, Cheng, Yaping, Chetverikov, Alexey, Chiesa, Davide, Chimenti, Pietro, Chukanov, Artem, Claverie, Gérard, Clementi, Catia, Clerbaux, Barbara, Conforti Di Lorenzo, Selma, Corti, Daniele, Cremonesi, Oliviero, Dal Corso, Flavio, Dalager, Olivia, De La Taille, Christophe, Deng, Jiawei, Deng, Zhi, Deng, Ziyan, Depnering, Wilfried, Diaz, Marco, Ding, Xuefeng, Ding, Yayun, Dirgantara, Bayu, Dmitrievsky, Sergey, Dohnal, Tadea, Dolzhikov, Dmitry, Donchenko, Georgy, Dong, Jianmeng, Doroshkevich, Evgeny, Dracos, Marco, Druillole, Frédéric, Du, Shuxian, Dusini, Stefano, Dvorak, Martin, Enqvist, Timo, Enzmann, Heike, Fabbri, Andrea, Fajt, Luka, Fan, Donghua, Fan, Lei, Fang, Jian, Fang, Wenxing, Fargetta, Marco, Fedoseev, Dmitry, Fekete, Vladko, Feng, Li-Cheng, Feng, Qichun, Ford, Richard, Formozov, Andrey, Fournier, Amélie, Gan, Haonan, Gao, Feng, Garfagnini, Alberto, Giammarchi, Marco, Giaz, Agnese, Giudice, Nunzio, Gonchar, Maxim, Gong, Guanghua, Gong, Hui, Gornushkin, Yuri, Göttel, Alexandre, Grassi, Marco, Grewing, Christian, Gromov, Vasily, Gu, Minghao, Gu, Xiaofei, Gu, Yu, Guan, Mengyun, Guardone, Nunzio, Gul, Maria, Guo, Cong, Guo, Jingyuan, Guo, Wanlei, Guo, Xinheng, Guo, Yuhang, Hackspacher, Paul, Hagner, Caren, Han, Ran, Han, Yang, Hassan, Muhammad Sohaib, He, Miao, He, Wei, Heinz, Tobia, Hellmuth, Patrick, Heng, Yuekun, Herrera, Rafael, Hor, Yuenkeung, Hou, Shaojing, Hsiung, Yee, Hu, Bei-Zhen, Hu, Hang, Hu, Jianrun, Hu, Jun, Hu, Shouyang, Hu, Tao, Hu, Zhuojun, Huang, Chunhao, Huang, Guihong, Huang, Hanxiong, Huang, Wenhao, Huang, Xin, Huang, Xingtao, Huang, Yongbo, Hui, Jiaqi, Huo, Lei, Huo, Wenju, Huss, Cédric, Hussain, Safeer, Ioannisian, Ara, Isocrate, Roberto, Jelmini, Beatrice, Jen, Kuo-Lun, Jeria, Ignacio, Ji, Xiaolu, Ji, Xingzhao, Jia, Huihui, Jia, Junji, Jian, Siyu, Jiang, Di, Jiang, Xiaoshan, Jin, Ruyi, Jing, Xiaoping, Jollet, Cécile, Joutsenvaara, Jari, Jungthawan, Sirichok, Kalousis, Leonida, Kampmann, Philipp, Kang, Li, Karaparambil, Rebin, Kazarian, Narine, Khan, Waseem, Khosonthongkee, Khanchai, Korablev, Deni, Kouzakov, Konstantin, Krasnoperov, Alexey, Kruth, Andre, Kutovskiy, Nikolay, Kuusiniemi, Pasi, Lachenmaier, Tobia, Landini, Cecilia, Leblanc, Sébastien, Lebrin, Victor, Lefevre, Frederic, Lei, Ruiting, Leitner, Rupert, Leung, Jason, Li, Demin, Li, Fei, Li, Fule, Li, Haitao, Li, Huiling, Li, Jiaqi, Li, Mengzhao, Li, Min, Li, Nan, Li, Qingjiang, Li, Ruhui, Li, Shanfeng, Li, Tao, Li, Weidong, Li, Weiguo, Li, Xiaomei, Li, Xiaonan, Li, Xinglong, Li, Yi, Li, Yufeng, Li, Zhaohan, Li, Zhibing, Li, Ziyuan, Liang, Hao, Liao, Jiajun, Liebau, Daniel, Limphirat, Ayut, Limpijumnong, Sukit, Lin, Guey-Lin, Lin, Shengxin, Lin, Tao, Ling, Jiajie, Lippi, Ivano, Liu, Fang, Liu, Haidong, Liu, Hongbang, Liu, Hongjuan, Liu, Hongtao, Liu, Hui, Liu, Jianglai, Liu, Jinchang, Liu, Min, Liu, Qian, Liu, Qin, Liu, Runxuan, Liu, Shuangyu, Liu, Shubin, Liu, Shulin, Liu, Xiaowei, Liu, Xiwen, Liu, Yan, Liu, Yunzhe, Lokhov, Alexey, Lombardi, Paolo, Lombardo, Claudio, Loo, Kai, Lu, Chuan, Lu, Haoqi, Lu, Jingbin, Lu, Junguang, Lu, Shuxiang, Lu, Xiaoxu, Lubsandorzhiev, Bayarto, Lubsandorzhiev, Sultim, Ludhova, Livia, Luo, Fengjiao, Luo, Guang, Luo, Pengwei, Luo, Shu, Luo, Wuming, Lyashuk, Vladimir, Ma, Bangzheng, Ma, Qiumei, Ma, Si, Ma, Xiaoyan, Ma, Xubo, Maalmi, Jihane, Malyshkin, Yury, Mantovani, Fabio, Manzali, Francesco, Mao, Xin, Mao, Yajun, Mari, Stefano M., Marini, Filippo, Marium, Sadia, Martellini, Cristina, Martin-Chassard, Gisele, Martini, Agnese, Mayer, Matthia, Mayilyan, Davit, Mednieks, Int, Meng, Yue, Meregaglia, Anselmo, Meroni, Emanuela, Meyhöfer, David, Mezzetto, Mauro, Miller, Jonathan, Miramonti, Lino, Montini, Paolo, Montuschi, Michele, Müller, Axel, Nastasi, Massimiliano, Naumov, Dmitry V., Naumova, Elena, Navas-Nicolas, Diana, Nemchenok, Igor, Nguyen Thi, Minh Thuan, Ning, Feipeng, Ning, Zhe, Nunokawa, Hiroshi, Oberauer, Lothar, Ochoa-Ricoux, Juan Pedro, Olshevskiy, Alexander, Orestano, Domizia, Ortica, Fausto, Othegraven, Rainer, Pan, Hsiao-Ru, Paoloni, Alessandro, Parmeggiano, Sergio, Pei, Yatian, Pelliccia, Nicomede, Peng, Anguo, Peng, Haiping, Perrot, Frédéric, Petitjean, Pierre-Alexandre, Petrucci, Fabrizio, Pilarczyk, Oliver, Piñeres Rico, Luis Felipe, Popov, Artyom, Poussot, Pascal, Pratumwan, Wathan, Previtali, Ezio, Qi, Fazhi, Qi, Ming, Qian, Sen, Qian, Xiaohui, Qian, Zhen, Qiao, Hao, Qin, Zhonghua, Qiu, Shoukang, Rajput, Muhammad Usman, Ranucci, Gioacchino, Raper, Neill, Re, Alessandra, Rebber, Henning, Rebii, Abdel, Ren, Bin, Ren, Jie, Ricci, Barbara, Robens, Marku, Roche, Mathieu, Rodphai, Narongkiat, Romani, Aldo, Roskovec, Bedřich, Roth, Christian, Ruan, Xiangdong, Ruan, Xichao, Rujirawat, Saroj, Rybnikov, Arseniy, Sadovsky, Andrey, Saggese, Paolo, Sanfilippo, Simone, Sangka, Anut, Sanguansak, Nuanwan, Sawangwit, Utane, Sawatzki, Julia, Sawy, Fatma, Schever, Michaela, Schwab, Cédric, Schweizer, Konstantin, Selyunin, Alexandr, Serafini, Andrea, Settanta, Giulio, Settimo, Mariangela, Shao, Zhuang, Sharov, Vladislav, Shaydurova, Arina, Shi, Jingyan, Shi, Yanan, Shutov, Vitaly, Sidorenkov, Andrey, Šimkovic, Fedor, Sirignano, Chiara, Siripak, Jaruchit, Sisti, Monica, Slupecki, Maciej, Smirnov, Mikhail, Smirnov, Oleg, Sogo-Bezerra, Thiago, Sokolov, Sergey, Songwadhana, Julanan, Soonthornthum, Boonrucksar, Sotnikov, Albert, Šrámek, Ondřej, Sreethawong, Warintorn, Stahl, Achim, Stanco, Luca, Stankevich, Konstantin, Štefánik, Dušan, Steiger, Han, Steinmann, Jochen, Sterr, Tobia, Stock, Matthias Raphael, Strati, Virginia, Studenikin, Alexander, Sun, Shifeng, Sun, Xilei, Sun, Yongjie, Sun, Yongzhao, Suwonjandee, Narumon, Szelezniak, Michal, Tang, Jian, Tang, Qiang, Tang, Quan, Tang, Xiao, Tietzsch, Alexander, Tkachev, Igor, Tmej, Toma, Treskov, Konstantin, Triossi, Andrea, Troni, Giancarlo, Trzaska, Wladyslaw, Tuve, Cristina, Ushakov, Nikita, van den Boom, Johanne, van Waasen, Stefan, Vanroyen, Guillaume, Vassilopoulos, Nikolao, Vedin, Vadim, Verde, Giuseppe, Vialkov, Maxim, Viaud, Benoit, Vollbrecht, Moritz Corneliu, Volpe, Cristina, Vorobel, Vit, Voronin, Dmitriy, Votano, Lucia, Walker, Pablo, Wang, Caishen, Wang, Chung-Hsiang, Wang, En, Wang, Guoli, Wang, Jian, Wang, Jun, Wang, Kunyu, Wang, Lu, Wang, Meifen, Wang, Meng, Wang, Ruiguang, Wang, Siguang, Wang, Wei, Wang, Wenshuai, Wang, Xi, Wang, Xiangyue, Wang, Yangfu, Wang, Yaoguang, Wang, Yi, Wang, Yifang, Wang, Yuanqing, Wang, Yuman, Wang, Zhe, Wang, Zheng, Wang, Zhimin, Wang, Zongyi, Waqas, Muhammad, Watcharangkool, Apimook, Wei, Lianghong, Wei, Wei, Wei, Wenlu, Wei, Yadong, Wen, Liangjian, Wiebusch, Christopher, Wong, Steven Chan-Fai, Wonsak, Bjoern, Wu, Diru, Wu, Fangliang, Wu, Qun, Wu, Zhi, Wurm, Michael, Wurtz, Jacque, Wysotzki, Christian, Xi, Yufei, Xia, Dongmei, Xie, Xiaochuan, Xie, Yuguang, Xie, Zhangquan, Xing, Zhizhong, Xu, Benda, Xu, Cheng, Xu, Donglian, Xu, Fanrong, Xu, Hangkun, Xu, Jilei, Xu, Jing, Xu, Meihang, Xu, Yin, Xu, Yu, Yan, Baojun, Yan, Taylor, Yan, Wenqi, Yan, Xiongbo, Yan, Yupeng, Yang, Anbo, Yang, Changgen, Yang, Chengfeng, Yang, Huan, Yang, Jie, Yang, Lei, Yang, Xiaoyu, Yang, Yifan, Yao, Haifeng, Yasin, Zafar, Ye, Jiaxuan, Ye, Mei, Ye, Ziping, Yegin, Ugur, Yermia, Frédéric, Yi, Peihuai, Yin, Na, Yin, 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Jiaheng, Institut Pluridisciplinaire Hubert Curien (IPHC), Institut National de Physique Nucléaire et de Physique des Particules du CNRS (IN2P3)-Université de Strasbourg (UNISTRA)-Centre National de la Recherche Scientifique (CNRS), Centre d'Etudes Nucléaires de Bordeaux Gradignan (CENBG), Université Sciences et Technologies - Bordeaux 1-Institut National de Physique Nucléaire et de Physique des Particules du CNRS (IN2P3)-Centre National de la Recherche Scientifique (CNRS), Centre de Physique des Particules de Marseille (CPPM), Aix Marseille Université (AMU)-Institut National de Physique Nucléaire et de Physique des Particules du CNRS (IN2P3)-Centre National de la Recherche Scientifique (CNRS), Laboratoire de Physique des 2 Infinis Irène Joliot-Curie (IJCLab), Institut National de Physique Nucléaire et de Physique des Particules du CNRS (IN2P3)-Université Paris-Saclay-Centre National de la Recherche Scientifique (CNRS), Laboratoire de physique subatomique et des technologies associées (SUBATECH), Université de Nantes - UFR des Sciences et des Techniques (UN UFR ST), Université de Nantes (UN)-Université de Nantes (UN)-Centre National de la Recherche Scientifique (CNRS)-Institut National de Physique Nucléaire et de Physique des Particules du CNRS (IN2P3)-IMT Atlantique Bretagne-Pays de la Loire (IMT Atlantique), Institut Mines-Télécom [Paris] (IMT)-Institut Mines-Télécom [Paris] (IMT), Abusleme A., Adam T., Ahmad S., Ahmed R., Aiello S., Akram M., An F., An Q., Andronico G., Anfimov N., Antonelli V., Antoshkina T., Asavapibhop B., de Andre J.P.A.M., Auguste D., Babic A., Baldini W., Barresi A., Basilico D., Baussan E., Bellato M., Bergnoli A., Birkenfeld T., Blin S., Blum D., Blyth S., Bolshakova A., Bongrand M., Bordereau C., Breton D., Brigatti A., Brugnera R., Bruno R., Budano A., Buscemi M., Busto J., Butorov I., Cabrera A., Cai H., Cai X., Cai Y., Cai Z., Cammi A., Campeny A., Cao C., Cao G., Cao J., Caruso R., Cerna C., Chang J., Chang Y., Chen P., Chen P.-A., Chen S., Chen X., Chen Y.-W., Chen Y., Chen Z., Cheng J., Cheng Y., Chetverikov A., Chiesa D., Chimenti P., Chukanov A., Claverie G., Clementi C., Clerbaux B., Conforti Di Lorenzo S., Corti D., Cremonesi O., Dal Corso F., Dalager O., De La Taille C., Deng J., Deng Z., Depnering W., Diaz M., Ding X., Ding Y., Dirgantara B., Dmitrievsky S., Dohnal T., Dolzhikov D., Donchenko G., Dong J., Doroshkevich E., Dracos M., Druillole F., Du S., Dusini S., Dvorak M., Enqvist T., Enzmann H., Fabbri A., Fajt L., Fan D., Fan L., Fang J., Fang W., Fargetta M., Fedoseev D., Fekete V., Feng L.-C., Feng Q., Ford R., Formozov A., Fournier A., Gan H., Gao F., Garfagnini A., Giammarchi M., Giaz A., Giudice N., Gonchar M., Gong G., Gong H., Gornushkin Y., Gottel A., Grassi M., Grewing C., Gromov V., Gu M., Gu X., Gu Y., Guan M., Guardone N., Gul M., Guo C., Guo J., Guo W., Guo X., Guo Y., Hackspacher P., Hagner C., Han R., Han Y., Hassan M.S., He M., He W., Heinz T., Hellmuth P., Heng Y., Herrera R., Hor Y.K., Hou S., Hsiung Y., Hu B.-Z., Hu H., Hu J., Hu S., Hu T., Hu Z., Huang C., Huang G., Huang H., Huang W., Huang X., Huang Y., Hui J., Huo L., Huo W., Huss C., Hussain S., Ioannisian A., Isocrate R., Jelmini B., Jen K.-L., Jeria I., Ji X., Jia H., Jia J., Jian S., Jiang D., Jiang X., Jin R., Jing X., Jollet C., Joutsenvaara J., Jungthawan S., Kalousis L., Kampmann P., Kang L., Karaparambil R., Kazarian N., Khan W., Khosonthongkee K., Korablev D., Kouzakov K., Krasnoperov A., Kruth A., Kutovskiy N., Kuusiniemi P., Lachenmaier T., Landini C., Leblanc S., Lebrin V., Lefevre F., Lei R., Leitner R., Leung J., Li D., Li F., Li H., Li J., Li M., Li N., Li Q., Li R., Li S., Li T., Li W., Li X., Li Y., Li Z., Liang H., Liao J., Liebau D., Limphirat A., Limpijumnong S., Lin G.-L., Lin S., Lin T., Ling J., Lippi I., Liu F., Liu H., Liu J., Liu M., Liu Q., Liu R., Liu S., Liu X., Liu Y., Lokhov A., Lombardi P., Lombardo C., Loo K., Lu C., Lu H., Lu J., Lu S., Lu X., Lubsandorzhiev B., Lubsandorzhiev S., Ludhova L., Luo F., Luo G., Luo P., Luo S., Luo W., Lyashuk V., Ma B., Ma Q., Ma S., Ma X., Maalmi J., Malyshkin Y., Mantovani F., Manzali F., Mao X., Mao Y., Mari S.M., Marini F., Marium S., Martellini C., Martin-Chassard G., Martini A., Mayer M., Mayilyan D., Mednieks I., Meng Y., Meregaglia A., Meroni E., Meyhofer D., Mezzetto M., Miller J., Miramonti L., Montini P., Montuschi M., Muller A., Nastasi M., Naumov D.V., Naumova E., Navas-Nicolas D., Nemchenok I., Nguyen Thi M.T., Ning F., Ning Z., Nunokawa H., Oberauer L., Ochoa-Ricoux J.P., Olshevskiy A., Orestano D., Ortica F., Othegraven R., Pan H.-R., Paoloni A., Parmeggiano S., Pei Y., Pelliccia N., Peng A., Peng H., Perrot F., Petitjean P.-A., Petrucci F., Pilarczyk O., Pineres Rico L.F., Popov A., Poussot P., Pratumwan W., Previtali E., Qi F., Qi M., Qian S., Qian X., Qian Z., Qiao H., Qin Z., Qiu S., Rajput M.U., Ranucci G., Raper N., Re A., Rebber H., Rebii A., Ren B., Ren J., Ricci B., Robens M., Roche M., Rodphai N., Romani A., Roskovec B., Roth C., Ruan X., Rujirawat S., Rybnikov A., Sadovsky A., Saggese P., Sanfilippo S., Sangka A., Sanguansak N., Sawangwit U., Sawatzki J., Sawy F., Schever M., Schwab C., Schweizer K., Selyunin A., Serafini A., Settanta G., Settimo M., Shao Z., Sharov V., Shaydurova A., Shi J., Shi Y., Shutov V., Sidorenkov A., Simkovic F., Sirignano C., Siripak J., Sisti M., Slupecki M., Smirnov M., Smirnov O., Sogo-Bezerra T., Sokolov S., Songwadhana J., Soonthornthum B., Sotnikov A., Sramek O., Sreethawong W., Stahl A., Stanco L., Stankevich K., Stefanik D., Steiger H., Steinmann J., Sterr T., Stock M.R., Strati V., Studenikin A., Sun S., Sun X., Sun Y., Suwonjandee N., Szelezniak M., Tang J., Tang Q., Tang X., Tietzsch A., Tkachev I., Tmej T., Treskov K., Triossi A., Troni G., Trzaska W., Tuve C., Ushakov N., van den Boom J., van Waasen S., Vanroyen G., Vassilopoulos N., Vedin V., Verde G., Vialkov M., Viaud B., Vollbrecht M.C., Volpe C., Vorobel V., Voronin D., Votano L., Walker P., Wang C., Wang C.-H., Wang E., Wang G., Wang J., Wang K., Wang L., Wang M., Wang R., Wang S., Wang W., Wang X., Wang Y., Wang Z., Waqas M., Watcharangkool A., Wei L., Wei W., Wei Y., Wen L., Wiebusch C., Wong S.C.-F., Wonsak B., Wu D., Wu F., Wu Q., Wu Z., Wurm M., Wurtz J., Wysotzki C., Xi Y., Xia D., Xie X., Xie Y., Xie Z., Xing Z., Xu B., Xu C., Xu D., Xu F., Xu H., Xu J., Xu M., Xu Y., Yan B., Yan T., Yan W., Yan X., Yan Y., Yang A., Yang C., Yang H., Yang J., Yang L., Yang X., Yang Y., Yao H., Yasin Z., Ye J., Ye M., Ye Z., Yegin U., Yermia F., Yi P., Yin N., Yin X., You Z., Yu B., Yu C., Yu H., Yu M., Yu X., Yu Z., Yuan C., Yuan Y., Yuan Z., Yue B., Zafar N., Zambanini A., Zavadskyi V., Zeng S., Zeng T., Zeng Y., Zhan L., Zhang A., Zhang F., Zhang G., Zhang H., Zhang J., Zhang P., Zhang Q., Zhang S., Zhang T., Zhang X., Zhang Y., Zhang Z., Zhao F., Zhao J., Zhao R., Zhao S., Zhao T., Zheng D., Zheng H., Zheng M., Zheng Y., Zhong W., Zhou J., Zhou L., Zhou N., Zhou S., Zhou T., Zhou X., Zhu J., Zhu K., Zhu Z., Zhuang B., Zhuang H., Zong L., Zou J., Université de Strasbourg (UNISTRA)-Université de Haute-Alsace (UHA) Mulhouse - Colmar (Université de Haute-Alsace (UHA))-Institut National de Physique Nucléaire et de Physique des Particules du CNRS (IN2P3)-Centre National de la Recherche Scientifique (CNRS), Université Sciences et Technologies - Bordeaux 1 (UB)-Institut National de Physique Nucléaire et de Physique des Particules du CNRS (IN2P3)-Centre National de la Recherche Scientifique (CNRS), Université de Nantes (UN)-Université de Nantes (UN)-Institut National de Physique Nucléaire et de Physique des Particules du CNRS (IN2P3)-Centre National de la Recherche Scientifique (CNRS)-IMT Atlantique (IMT Atlantique), JUNO collaboration, The, Pedro Athayde Marcondes de André, João, Sohaib Hassan, Muhammad, Thuan Nguyen Thi, Minh, Pedro Ochoa-Ricoux, Juan, Felipe Piñeres Rico, Lui, Usman Rajput, Muhammad, Raphael Stock, Matthia, Cornelius Vollbrecht, Moritz, and Chan-Fai Wong, Steven
Subjects: Nuclear and High Energy Physics, Physics - Instrumentation and Detectors, Physics::Instrumentation and Detectors, Nuclear engineering, Monte Carlo method, Control (management), measurement methods, FOS: Physical sciences, QC770-798, Scintillator, 7. Clean energy, 01 natural sciences, NO, PE2_2, Nuclear and particle physics. Atomic energy. Radioactivity, 0103 physical sciences, [PHYS.HEXP]Physics [physics]/High Energy Physics - Experiment [hep-ex], ddc:530, Sensitivity (control systems), 010306 general physics, Physics, JUNO, liquid [scintillation counter], 010308 nuclear & particles physics, business.industry, Detector, Settore FIS/01 - Fisica Sperimentale, radioactivity [background], suppression [background], Instrumentation and Detectors (physics.ins-det), Monte Carlo [numerical calculations], Nuclear power, threshold [energy], sensitivity, Neutrino Detectors and Telescopes (experiments), GEANT, Neutrino, business, Energy (signal processing)
Abstract: JUNO is a massive liquid scintillator detector with a primary scientific goal of determining the neutrino mass ordering by studying the oscillated anti-neutrino flux coming from two nuclear power plants at 53 km distance. The expected signal anti-neutrino interaction rate is only 60 counts per day, therefore a careful control of the background sources due to radioactivity is critical. In particular, natural radioactivity present in all materials and in the environment represents a serious issue that could impair the sensitivity of the experiment if appropriate countermeasures were not foreseen. In this paper we discuss the background reduction strategies undertaken by the JUNO collaboration to reduce at minimum the impact of natural radioactivity. We describe our efforts for an optimized experimental design, a careful material screening and accurate detector production handling, and a constant control of the expected results through a meticulous Monte Carlo simulation program. We show that all these actions should allow us to keep the background count rate safely below the target value of 10 Hz in the default fiducial volume, above an energy threshold of 0.7 MeV., 35 pages, 12 figures
Published: 2021

7. FPGA Implementation of an NCO Based CDR for the JUNO Front-End Electronics

Author: Antonio Bergnoli, Monica Sisti, Antonio Budano, Michele Montuschi, D. Riondino, Andrey Formozov, A. Cammi, Ezio Previtali, Fabio Mantovani, Barbara Ricci, Agnese Giaz, Rossella Caruso, L. Stanco, S. Parmeggiano, Marco Danilo Claudio Torri, P. Saggese, S. Dusini, W. Bandini, Ivano Lippi, D. Corti, Andrea Fabbri, Cristina Tuve, Andrea Serafini, Cecilia Landini, Richard Ford, L. Votano, M. Mezzetto, Lino Miramonti, Massimiliano Nastasi, D. Basilico, Fausto Ortica, Marco Giammarchi, G. H. Gong, A. Brigatti, Chiara Sirignano, Alessandro Paoloni, M. Bellato, Paolo Lombardi, Xuefeng Ding, Salvatore Costa, Virginia Strati, Jianrun Hu, Xiaoshan Jiang, Andrea Barresi, Agnese Martini, G. Andronico, S. M. Mari, Roberto Isocrate, Sebastiano Aiello, Alessandra Re, Jianmeng Dong, Nicomede Pelliccia, R. Brugnera, Claudio Lombardo, B. Caccianiga, Marco Fargetta, Aldo Romani, Riccardo Bruno, Paolo Montini, Marco Grassi, Catia Clementi, Davide Chiesa, A. Garfagnini, Vito Antonelli, F. Dal Corso, Gioacchino Ranucci, Giuseppe Verde, Cristina Martellini, E. Meroni, Filippo Marini, K. von Sturm, Marini, F., Bellato, M., Bergnoli, A., Brugnera, R., Dal Corso, F., Corti, D., Dong, J., Garfagnini, A., Giaz, A., Gong, G., Hu, J., Isocrate, R., Jiang, X., Lippi, I., Von Sturm, K., Aiello, S., Andronico, G., Antonelli, V., Bandini, W., Basilico, D., Brigatti, A., Barresi, A., Budano, A., Bruno, R., Caccianiga, B., Cammi, A., Caruso, R., Chiesa, D., Clementi, C., Costa, S., Ding, X., Dusini, S., Fabbri, A., Fargetta, M., Ford, R., Formozov, A., Giammarchi, M., Grassi, M., Landini, C., Lombardi, P., Lombardo, C., Mantovani, F., Mari, S. M., Martellini, C., Martini, A., Meroni, E., Mezzetto, M., Miramonti, L., Montini, P., Montuschi, M., Nastasi, M., Ortica, F., Paoloni, A., Parmeggiano, S., Pelliccia, N., Previtali, E., Ranucci, G., Riondino, D., Re, A. C., Ricci, B., Romani, A., Saggese, P., Serafini, A., Sirignano, C., Sisti, M., Stanco, L., Strati, V., Torri, M., Tuve, C., Verde, G., Votano, L., Marini, F, Bellato, M, Bergnoli, A, Brugnera, R, Dal Corso, F, Corti, D, Dong, J, Garfagnini, A, Giaz, A, Gong, G, Hu, J, Isocrate, R, Jiang, X, Lippi, I, Von Sturm, K, Aiello, S, Andronico, G, Antonelli, V, Bandini, W, Basilico, D, Brigatti, A, Barresi, A, Budano, A, Bruno, R, Caccianiga, B, Cammi, A, Caruso, R, Chiesa, D, Clementi, C, Costa, S, Ding, X, Dusini, S, Fabbri, A, Fargetta, M, Ford, R, Formozov, A, Giammarchi, M, Grassi, M, Landini, C, Lombardi, P, Lombardo, C, Mantovani, F, Mari, S, Martellini, C, Martini, A, Meroni, E, Mezzetto, M, Miramonti, L, Montini, P, Montuschi, M, Nastasi, M, Ortica, F, Paoloni, A, Parmeggiano, S, Pelliccia, N, Previtali, E, Ranucci, G, Riondino, D, Re, A, Ricci, B, Romani, A, Saggese, P, Serafini, A, Sirignano, C, Sisti, M, Stanco, L, Strati, V, Torri, M, Tuve, C, Verde, G, and Votano, L
Subjects: Nuclear and High Energy Physics, phase aligner (PA), Clock signal, Computer science, Clock rate, CDR, Clock and data recovery (CDR), eye pattern, field-programmable gate array (FPGA), numerically-controlled oscillator (NCO), phase detector (PD), Phase detector, Digital clock, NO, PE2_2, Electrical and Electronic Engineering, Field-programmable gate array, Clock recovery, CDR ,NCO , phase detector, phase aligner , FPGA , eye pattern, FPGA, Jitter, phase aligner, business.industry, Detector, Nuclear Energy and Engineering, NCO, phase detector, business, Computer hardware
Abstract: This article describes a design of an field-programmable gate array (FPGA) implementation of a clock and data recovery (CDR) system. The core will be integrated in the FPGA configuration for the front-end electronics (FEE) board of the Jiangmen underground neutrino observatory (JUNO) experiment. The front-end will be placed on the main detector, underground and underwater, making the electronics not accessible after installation. The timing and trigger system relies on a synchronous link connection over CAT5e cable (up to 100 m long) between the front-end and the back-end electronics (BEE), where a twisted-pair is dedicated to clock-forwarding. The robustness of the recovery clock system is essential for the stability of the FPGA firmware. The proposed project is intended to improve the clock recovery operation by increasing the immunity of the link to sudden electromagnetic interference (EMI). On top of this, the core allows to free a twisted-pair in the link, since the clock can be recovered from the data and there is no more need for a clock-dedicated transmission. This will optimize the link granting the possibility to implement other features. The design is based on two components: a numerically-controlled oscillator (NCO), in order to create a controlled frequency clock signal, and a digital phase detector (PD) to match the clock frequency with the data rate. NCOs are often coupled with a digital-to-analog converter (DAC) to create direct digital synthesizers (DDSs), which are able to produce analog waveforms of any desired frequency. In the presented case instead, the NCO generates a digital clock signal of an arbitrary frequency, while the PD manages this frequency by intercepting any shifting on the relative phase between the clock and the data. A phase aligner (PA) module guarantees that data are sampled in the middle of the eye pattern, which represents the optimal sampling point. The article presents an overview of the NCO-based CDR design and implementation, together with some tests and results in order to verify the CDR reliability. Moreover, in the last section, some other possible applications of the core are illustrated.
Published: 2021

8. Analysis of a Station Black-Out transient in SMR by using the TRACE and RELAP5 code

Author: S D'Amico, Pierluigi Chiovaro, I. Moscato, Giuseppe Vella, C Lombardo, F. Mascari, F. De Rosa, M Polidori, Polidori, M., Mascari, F., Lombardo, C., De Rosa, F., De Rosa, F, Lombardo, C, Mascari, F, Polidori, M, Chiovaro, P, D’Amico, S, Moscato, I, and Vella, G
Subjects: History, Engineering, RELAP5, business.industry, Event (computing), Nuclear engineering, Nuclear fission, TRACE, SMR, Nuclear reactors -- Models -- Italy, Computer Science Applications, Education, Small modular reactor, Nuclear reactors -- Safety measures, Code (cryptography), Black out, Christian ministry, Transient (computer programming), business, Settore ING-IND/19 - Impianti Nucleari, Simulation, TRACE (psycholinguistics)
Abstract: The present paper deals with the investigation of the evolution and consequences of a Station Black-Out (SBO) initiating event transient in the SPES3 facility [1]. This facility is an integral simulator of a small modular reactor being built at the SIET laboratories, in the framework of the R&D program on nuclear fission funded by the Italian Ministry of Economic Development and led by ENEA. The SBO transient will be simulated by using the RELAP5 and TRACE nodalizations of the SPES3 facility. Moreover, the analysis will contribute to study the differences on the code predictions considering the different modelling approach with one and/or three-dimensional components and to compare the capability of these codes to describe the SPES3 facility behaviour., peer-reviewed
Published: 2014

9. Impact of Neoadjuvant Therapy in Resected Pancreatic Ductal Adenocarcinoma of the Pancreatic Body or Tail on Surgical and Oncological Outcome: A Propensity-Score Matched Multicenter Study

Author: Morgan Bonds, M. De Pastena, Giuseppe Malleo, Riccardo Casadei, Safi Dokmak, M. Abu Hilal, Adnan Alseidi, Carlo Lombardo, Tobias Keck, Claudio Ricci, J. van Hilst, Ales Tomazic, Ugo Boggi, Gianpaolo Balzano, Alessandro Giardino, Bjørn Edwin, Guido Fiorentini, Giovanni Capretti, Giovanni Butturini, Massimo Falconi, S. Lof, Maarten Korrel, M.G. Besselink, H. Wilmink, Alessandro Zerbi, Graduate School, Surgery, AGEM - Digestive immunity, AGEM - Endocrinology, metabolism and nutrition, AGEM - Re-generation and cancer of the digestive system, CCA - Cancer Treatment and Quality of Life, Oncology, Lof S., Korrel M., van Hilst J., Alseidi A., Balzano G., Boggi U., Butturini G., Casadei R., Dokmak S., Edwin B., Falconi M., Keck T., Malleo G., de Pastena M., Tomazic A., Wilmink H., Zerbi A., Besselink M.G., Abu Hilal M., Bonds M., Capretti G., Fiorentini G., Giardino A., Lombardo C., and Ricci C.
Subjects: Male, medicine.medical_specialty, Internationality, FOLFIRINOX, medicine.medical_treatment, Leucovorin, Adenocarcinoma, Irinotecan, Gastroenterology, Pancreatic Fistula, Pancreatectomy, Postoperative Complications, Retrospective Studie, Internal medicine, Antineoplastic Combined Chemotherapy Protocols, medicine, Pancrea, Humans, Prospective cohort study, Propensity Score, Pancreas, Neoadjuvant therapy, Survival analysis, Aged, Retrospective Studies, Antineoplastic Combined Chemotherapy Protocol, business.industry, Pancreatic Neoplasm, Retrospective cohort study, Pancreatic Tumors, Middle Aged, medicine.disease, Survival Analysis, Neoadjuvant Therapy, body regions, Oxaliplatin, Pancreatic Neoplasms, medicine.anatomical_structure, Oncology, Pancreatic fistula, Surgery, Female, Postoperative Complication, Survival Analysi, Fluorouracil, business, Human
Abstract: Background Several studies have suggested a survival benefit of neoadjuvant therapy (NAT) for pancreatic ductal adenocarcinoma (PDAC) in the pancreatic head. Data concerning NAT for PDAC located in pancreatic body or tail are lacking. Methods Post hoc analysis of an international multicenter retrospective cohort of distal pancreatectomy for PDAC in 34 centers from 11 countries (2007–2015). Patients who underwent resection after NAT were matched (1:1 ratio), using propensity scores based on baseline characteristics, to patients who underwent upfront resection. Median overall survival was compared using the stratified log-rank test. Results Among 1236 patients, 136 (11.0%) received NAT, most frequently FOLFIRINOX (25.7%). In total, 94 patients receiving NAT were matched to 94 patients undergoing upfront resection. NAT was associated with less postoperative major morbidity (Clavien–Dindo ≥ 3a, 10.6% vs. 23.4%, P = 0.020) and pancreatic fistula grade B/C (9.6% vs. 21.3%, P = 0.026). NAT did not improve overall survival [27 (95% CI 14–39) versus 31 months (95% CI 19–42), P = 0.277], as compared with upfront resection. In a sensitivity analysis of 251 patients with radiographic tumor involvement of splenic vessels, NAT (n = 37, 14.7%) was associated with prolonged overall survival [36 (95% CI 18–53) versus 20 months (95% CI 15–24), P = 0.049], as compared with upfront resection. Conclusion In this international multicenter cohort study, NAT for resected PDAC in pancreatic body or tail was associated with less morbidity and pancreatic fistula but similar overall survival in comparison with upfront resection. Prospective studies should confirm a survival benefit of NAT in patients with PDAC and splenic vessel involvement.
Published: 2019

10. Diagnostic and prognostic value of three micrornas in environmental asbestiform fibers-associated malignant mesothelioma

Author: Caterina Ledda, Carla Loreto, Venerando Rapisarda, Luca Falzone, Sergio Castorina, Veronica Filetti, Emanuele Cannizzaro, Claudia Lombardo, Filetti V., Loreto C., Falzone L., Lombardo C., Cannizzaro E., Castorina S., Ledda C., and Rapisarda V.
Subjects: Oncology, medicine.medical_specialty, Fluoro-edenite, diagnosis, Medicine (miscellaneous), Asbesto, Asbestiform, medicine.disease_cause, Asbestos, Article, Internal medicine, microRNA, medicine, Digital polymerase chain reaction, Mesothelioma, Malignant mesothelioma, Receiver operating characteristic, business.industry, Incidence (epidemiology), MicroRNA, Environmental exposure, medicine.disease, asbestos, Prognosis, Medicine, business, Diagnosi
Abstract: Fluoro-edenite (FE) is an asbestiform fiber identified in Biancavilla (Sicily, Italy). Environmental exposure to FE has been associated with a higher incidence of malignant mesothelioma (MM). The present study aimed to validate the predicted diagnostic significance of hsa-miR-323a-3p, hsa-miR-101-3p, and hsa-miR-20b-5p on a subset of MM patients exposed to FE and matched with healthy controls. For this purpose, MM tissues vs. nonmalignant pleura tissues were analyzed through droplet digital PCR (ddPCR) to evaluate differences in the expression levels of the selected miRNAs and their MM diagnostic potential. In addition, further computational analysis has been performed to establish the correlation of these miRNAs with the available online asbestos exposure data and clinic-pathological parameters to verify the potential role of these miRNAs as prognostic tools. ddPCR results showed that the three analyzed miRNAs were significantly down-regulated in MM cases vs. controls. Receiver operating characteristic (ROC) analysis revealed high specificity and sensitivity rates for both hsa-miR-323a-3p and hsa-miR-20b-5p, which thus acquire a diagnostic value for MM. In silico results showed a potential prognostic role of hsa-miR-101-3p due to a significant association of its higher expression and increased overall survival (OS) of MM patients.
Published: 2021

11. Comorbidities impact and de-prescribing in elderly with HCV-related liver disease: analysis of a prospective cohort

Author: Giuseppe Montalto, Filippo Alessandro Montalto, Luigi Mirarchi, Lydia Giannitrapani, Maria Giovanna Minissale, Maurizio Soresi, Clelia Lombardo, Anna Licata, Simona Amodeo, Licata A., Minissale M.G., Giannitrapani L., Montalto F.A., Lombardo C., Mirarchi L., Amodeo S., Soresi M., and Montalto G.
Subjects: Male, medicine.medical_specialty, Settore MED/09 - Medicina Interna, Comorbidity, Hepacivirus, DDI int eraction, Antiviral Agents, Co-morbiditie, De-prescribing, 03 medical and health sciences, Liver disease, Elderly, 0302 clinical medicine, Quality of life, Internal medicine, Diabetes mellitus, Internal Medicine, medicine, Humans, 030212 general & internal medicine, Prospective Studies, Prospective cohort study, Depression (differential diagnoses), Aged, business.industry, Charlson Index, Hepatitis C, Chronic, medicine.disease, Regimen, HCV, Emergency Medicine, Quality of Life, 030211 gastroenterology & hepatology, Female, business, Dyslipidemia, Kidney disease
Abstract: Management for HCV has undergone a notable change using direct-acting antiviral drugs (DAAs), which are safe and effective even in elderly. Here, we define impact of comorbidities, concomitant medication and drug–drug interactions in elder patients with HCV related disease before starting DAAs regimen. We analyzed data of 814 patients prospectively enrolled at our Unit within the web based model HCV Sicily Network. Out of 814, 590 were treated with DAAs and 414 of them were older than 65 years. We divided those 414 in two groups, one including 215 patients, aged between 65 and 74 years, and another with 199 patients, aged of 75 years and over. Charlson Comorbidity Index (CCI) was assessed for each patient; drug–drug interactions (DDI) and de-prescribing process were carried out appropriately. Within 414 patients included, percentage rates of women treated was higher than males, BMI was lower and cirrhosis was frequently reported in patients older than 75 years. Hypertension, diabetes mellitus, dyslipidemia (p p p p
Published: 2021

12. Embedded readout electronics R&D for the large PMTs in the JUNO experiment

Author: Claudio Lombardo, S. Parmeggiano, Salvatore Costa, Jianrun Hu, Cristina Martellini, Nicomede Pelliccia, D. Corti, Andrea Fabbri, Xiongbo Yan, M. Mezzetto, Paolo Lombardi, Davide Chiesa, A. Garfagnini, Antonio Cammi, Roberto Isocrate, Jianmeng Dong, Anatael Cabrera, Alessandra Re, Jochen Steinmann, Z. Ning, Antonio Bergnoli, Andrea Serafini, Cecilia Landini, Augusto Brigatti, Monica Sisti, Zhang Chen, Jinnan Zhang, Fausto Ortica, S. van Waasen, Z. M. Wang, Giuseppe Verde, Giuseppe Salamanna, F. Li, Agnese Giaz, A. Brugnera, Antonio Budano, Michele Montuschi, Wenlu Wei, Song Chen, Yuman Wang, Richard Ford, M. Bellato, A. Stahl, Y. Yang, Marco Giammarchi, L. Stanco, E. Meroni, W. Bandini, Filippo Marini, P. Saggese, G. Galet, Ivano Lippi, Vitaly Shutov, Vito Antonelli, Alessandro Paoloni, D. Riondino, Barbara Clerbaux, Markus Robens, Cristina Tuve, S. Dusini, Andrey Formozov, Xuefeng Ding, G. Settanta, G. H. Gong, Fabio Mantovani, D. Pedretti, Giovanni Fiorentini, A. Barresi, Massimiliano Nastasi, Ezio Previtali, Barbara Ricci, Agnese Martini, Gioacchino Ranucci, Rossella Caruso, Yury Malyshkin, A. Aiello, A. Andronico, Pierre-Alexandre Petitjean, Chiara Sirignano, Virginia Strati, Xiaoshan Jiang, S. M. Mari, L. Votano, Lino Miramonti, Fatma Sawy, Alexander Olshevskiy, Y. J. Sun, Marco Fargetta, Aldo Romani, Riccardo Bruno, Christian Grewing, Paolo Montini, Marco Grassi, Catia Clementi, F. Dal Corso, Laboratoire de Physique des 2 Infinis Irène Joliot-Curie (IJCLab), Institut National de Physique Nucléaire et de Physique des Particules du CNRS (IN2P3)-Université Paris-Saclay-Centre National de la Recherche Scientifique (CNRS), Bellato, M., Bergnoli, A., Brugnera, A., Chen, S., Chen, Z., Clerbaux, B., dal Corso, F., Corti, D., Dong, J., Galet, G., Garfagnini, A., Giaz, A., Gong, G., Grewing, C., Hu, J., Isocrate, R., Jiang, X., Li, F., Lippi, I., Marini, F., Ning, Z., Olshevskiy, A., Pedretti, D., Petitjean, P. A., Robens, M., Shutov, V., Stahl, A., Steinmann, J., Sun, Y., van Waasen, S., Wang, Y., Wang, Z., Wei, W., Yan, X., Yang, Y., Aiello, A., Andronico, A., Antonelli, V., Bandini, W., Brigatti, A., Barresi, A., Budano, A., Bruno, R., Cabrera, A., Cammi, A., Caruso, R., Chiesa, D., Clementi, C., Costa, S., Ding, X., Dusini, S., Fabbri, A., Fargetta, M., Fiorentini, G., Ford, R., Formozov, A., Giammarchi, M., Grassi, M., Landini, C., Lombardi, P., Lombardo, C., Malyshkin, Y., Mantovani, F., Mari, S. M., Martellini, C., Martini, A., Meroni, E., Mezzetto, M., Miramonti, L., Montini, P., Montuschi, M., Nastasi, M., Ortica, F., Paoloni, A., Parmeggiano, S., Pelliccia, N., Previtali, E., Ranucci, G., Riondino, D., Re, A. C., Ricci, B., Romani, A., Saggese, P., Salamanna, G., Sawy, F. H., Serafini, A., Settanta, G., Sirignano, C., Sisti, M., Stanco, L., Strati, V., Tuvé, C., Verde, G., Votano, L., and Zhang, J.
Subjects: Nuclear and High Energy Physics, Photomultiplier, Physics - Instrumentation and Detectors, Electronics, Large scale neutrino experiment, Physics::Instrumentation and Detectors, scintillation counter: liquid, 01 natural sciences, 7. Clean energy, NO, High Energy Physics - Experiment, 0103 physical sciences, [PHYS.HEXP]Physics [physics]/High Energy Physics - Experiment [hep-ex], ddc:530, [PHYS.PHYS.PHYS-INS-DET]Physics [physics]/Physics [physics]/Instrumentation and Detectors [physics.ins-det], 010306 general physics, Electronics, Photomultiplier, Large scale neutrino experiment, Instrumentation, Jiangmen Underground Neutrino Observatory, Physics, JUNO, 010308 nuclear & particles physics, Dynamic range, business.industry, Detector, Electrical engineering, Linearity, Analog signal, electronics: readout, Neutrino, business, performance, electronics: design
Abstract: Jiangmen Underground neutrino Observatory (JUNO) is a next generation liquid scintillator neutrino experiment under construction phase in South China. Thanks to the anti-neutrinos produced by the nearby nuclear power plants, JUNO will primarily study the neutrino mass hierarchy, one of the open key questions in neutrino physics. One key ingredient for the success of the measurement is to use high speed, high resolution sampling electronics located very close to the detector signal. Linearity in the response of the electronics in another important ingredient for the success of the experiment. During the initial design phase of the electronics, a custom design, with the Front-End and Read-Out electronics located very close to the detector analog signal has been developed and successfully tested. The present paper describes the electronics structure and the first tests performed on the prototypes. The electronics prototypes have been tested and they show good linearity response, with a maximum deviation of 1.3% over the full dynamic range (1-1000 p.e.), fulfilling the JUNO experiment requirements., Comment: 20 pages, 15 figures
Published: 2021

13. MacroH2A1 Immunoexpression in Breast Cancer

Author: Ermanno Vitale, Caterina Ledda, Silvia Varricchio, Carla Loreto, Claudia Lombardo, Giuseppe Broggi, Rosario Caltabiano, Antonio Ieni, Venerando Rapisarda, Daniela Russo, Veronica Filetti, Giovanni Tuccari, Broggi, G., Filetti, V., Ieni, A., Rapisarda, V., Ledda, C., Vitale, E., Varricchio, S., Russo, D., Lombardo, C., Tuccari, G., Caltabiano, R., and Loreto, C.
Subjects: 0301 basic medicine, Cancer Research, breast cancer, immunohistochemistry, macroH2A1, metastases, prognosis, Malignancy, lcsh:RC254-282, 03 medical and health sciences, breast cancer, 0302 clinical medicine, Breast cancer, Medicine, metastases, Original Research, business.industry, Cancer, Bone metastasis, macroH2A1, lcsh:Neoplasms. Tumors. Oncology. Including cancer and carcinogens, medicine.disease, Metastatic breast cancer, 030104 developmental biology, Oncology, metastase, 030220 oncology & carcinogenesis, immunohistochemistry, Cancer cell, Cancer research, Immunohistochemistry, prognosis, business, NODAL
Abstract: MacroH2A1 has two splice isoforms, macroH2A1.1 and macroH2A1.2, that have been studied in several form of cancer. In the literature there are not many scientific papers dealing with the role of macroH2A1 in breast cancer. Breast cancer is the most frequent form of malignancy in females. It tend to metastasize to the bone in ~70% of patients. Despite treatment, new bone metastases will still occur in 30–50% of cases with advanced disease. Overall 5-year survival after the diagnosis of bone metastasis is ~20%. Osteoclasts and osteoblasts of the bone microenvironment are engaged by soluble factors released by neoplastic cells, resulting in bone matrix breakdown. This malfunction enhances the proliferation of the cancer cells, creating a vicious cycle. We investigated immunohistochemical expression of macroH2A1 in primitive breast cancer, focusing on the comparison of metastatic and non-metastatic cases. Furthermore, the immunohistochemical expression of macroH2A1 has been evaluated both in all cases of nodal metastases and in distant metastases. Our data demonstrated that macroH2A1 expression was higher expressed in metastatic breast cancer (77%) vs. non-metastatic breast cancer (32%). Also in analyzed metastases cases, a high macroH2A1 expression was detected: 85 and 80% in nodal and distant metastases cases, respectively. These results supported the fact that macroH2A1 is more highly expressed in breast cancer with worst prognosis.
Published: 2020

14. Interventions for sleep problems during pregnancy: a systematic review

Author: Paola De Bartolo, Valeria Bacaro, Chiara Baglioni, Bernd Feige, Fee Benz, Andrea Pappaccogli, Anna F. Johann, Caterina Lombardo, Laura Palagini, Dieter Riemann, Bacaro V., Benz F., Pappaccogli A., De Bartolo P., Johann A.F., Palagini L., Lombardo C., Feige B., Riemann D., and Baglioni C.
Subjects: Pulmonary and Respiratory Medicine, Sleep Initiation and Maintenance Disorder, medicine.medical_specialty, Mindfulness, insomnia, MEDLINE, Psychological intervention, maternal mental health, PsycINFO, law.invention, NO, 03 medical and health sciences, Intervention, Treatment, Insomnia, Sleep quality, Pregnancy, Maternal mental health, Systematic review, 0302 clinical medicine, Randomized controlled trial, Drug Therapy, systematic review, law, Sleep Initiation and Maintenance Disorders, Physiology (medical), medicine, Insomnia, Acupuncture, Humans, intervention, treatment, sleep quality, pregnancy, Pregnancy, Cognitive Behavioral Therapy, business.industry, medicine.disease, 030228 respiratory system, Neurology, Physical therapy, Female, Neurology (clinical), medicine.symptom, business, Sleep, 030217 neurology & neurosurgery, Human
Abstract: Sleep problems during pregnancy are prevalent and could be linked to negative outcomes during pregnancy or post-partum. However, these complaints are often underdiagnosed and undertreated. This review aimed to systematically assess the effectiveness of different interventions to ameliorate poor sleep quality and insomnia during pregnancy. Pubmed, PsycINFO and Medline databases were systematically searched without publication period restriction until 3rd May 2019. Eligible studies had to: include pregnant women of any age and gestational age; use clinical intervention designs targeted at improving sleep outcome; report pre- and post-treatment data for one or more sleep-related outcomes; be published in English, Italian, German, Spanish, or French. Sixteen studies were selected including 1252 expecting mothers. Studies evaluated the efficacy of various interventions: cognitive behavioral interventions for insomnia (4); pharmacotherapy (1); acupuncture (1); mindfulness and yoga (3); relaxation (5) and herbal medication (2). Only six were randomized controlled trials, and only four evaluated longitudinal outcomes. Preliminary support was found for all interventions, but our knowledge is still too limited by lack of evidence. There is an utmost urgency to perform high-quality randomized controlled trials for insomnia interventions during pregnancy and to implement effective programs in standard gynecological care.
Published: 2020

15. Reply to Zhang et al.: Commentary interventions for sleep problems during pregnancy

Author: Valeria Bacaro, Bernd Feige, Paola De Bartolo, Caterina Lombardo, Dieter Riemann, Chiara Baglioni, Andrea Pappaccogli, Anna F. Johann, Fee Benz, Laura Palagini, Bacaro V., Benz F., Pappaccogli A., De Bartolo P., Johann A.F., Palagini L., Lombardo C., Feige B., Riemann D., and Baglioni C.
Subjects: Pulmonary and Respiratory Medicine, Sleep Wake Disorders, medicine.medical_specialty, Insomnia, Zhàng, Psychological intervention, Intervention, Pregnancy, Physiology (medical), medicine, Humans, Psychiatry, Maternal mental health, business.industry, Sleep quality, medicine.disease, Sleep in non-human animals, Treatment, Neurology, Systematic review, Female, Neurology (clinical), business, Human
Abstract: n/a
Published: 2020

16. Minimally Invasive versus Open Distal Pancreatectomy for Ductal Adenocarcinoma (DIPLOMA): A Pan-European Propensity Score Matched Study

Author: Giovanni Butturini, Santiago Sánchez-Cabús, Igor Khatkov, Sophia Chikhladze, Susan van Dieren, John N. Primrose, Isacco Damoli, Olivier R. Busch, Marco Montorsi, Ugo Boggi, Irfan Kabir, Marco Del Chiaro, Per Sandström, Bas Groot Koerkamp, Guido A. M. Tiberio, Zahir Soonawalla, K. Menon, Andrea Pietrabissa, Robert P. Sutcliffe, Lauren Scovel, Steven A. White, Brice Gayet, Riccardo Casadei, Bergthor Björnsson, Safi Dokmak, Alessandro Zerbi, Zeeshan Ateeb, Leonardo Solaini, Ignaci Poves, Federica Cipriani, Roberto Troisi, Jean-Marie Fabre, Ales Tomazic, Massimo Falconi, Tobias Keck, Marc G. Besselink, Claudio Ricci, Claudio Bassi, Ryne Marshall, Bilal Al-Sarireh, Uwe A. Wittel, Sjors Klompmaker, Frederik Berrevoet, Marion Orville, Casper H.J. van Eijck, Matthias Hassenpflug, Antonello Forgione, Mushegh A. Sahakyan, Bjørn Edwin, Masa Kusar, Gianpaolo Balzano, F. Régis Souche, Francesca Aleotti, Bård I. Røsok, M. Rawashdeh, Francesca Gavazzi, Giovanni Marchegiani, Adnan Alseidi, Carlo Lombardo, Thijs de Rooij, David Fuks, Ulrich F. Wellner, Thilo Hackert, Olivier Farges, Mohammad Abu Hilal, Jony van Hilst, Laureano Fernández-Cruz, Ronald M. van Dam, Isabella Frigerio, Raffaele Pugliese, Keith J. Roberts, Matteo De Pastena, Alessandro Giardino, Service de chirurgie hepato-pancreato-biliaire, Hôpital Beaujon [AP-HP], Assistance publique - Hôpitaux de Paris (AP-HP) (AP-HP)-Assistance publique - Hôpitaux de Paris (AP-HP) (AP-HP)-Université Paris Diderot - Paris 7 (UPD7), Centre Hospitalier Régional Universitaire [Montpellier] (CHRU Montpellier), San Raffaele Scientific Institute, Vita-Salute San Raffaele University and Center for Translational Genomics and Bioinformatics, Institut de Recherche en Cancérologie de Montpellier (IRCM - U1194 Inserm - UM), CRLCC Val d'Aurelle - Paul Lamarque-Institut National de la Santé et de la Recherche Médicale (INSERM)-Université de Montpellier (UM), Van Hilst, Jony, De Rooij, Thij, Klompmaker, Sjor, Rawashdeh, Majd, Aleotti, Francesca, Al sarireh, Bilal, Alseidi, Adnan, Ateeb, Zeeshan, Balzano, Gianpaolo, Berrevoet, Frederik, Björnsson, Bergthor, Boggi, Ugo, Busch, Olivier R, Butturini, Giovanni, Casadei, Riccardo, Del Chiaro, Marco, Chikhladze, Sophia, Cipriani, Federica, Van Dam, Ronald, Damoli, Isacco, Van Dieren, Susan, Dokmak, Safi, Edwin, Bjørn, Van Eijck, Casper, Fabre, Jean marie, Falconi, Massimo, Farges, Olivier, Fernández cruz, Laureano, Forgione, Antonello, Frigerio, Isabella, Fuks, David, Gavazzi, Francesca, Gayet, Brice, Giardino, Alessandro, Bas Groot, Koerkamp, Hackert, Thilo, Hassenpflug, Matthia, Kabir, Irfan, Keck, Tobia, Khatkov, Igor, Kusar, Masa, Lombardo, Carlo, Marchegiani, Giovanni, Marshall, Ryne, Menon, Krish V, Montorsi, Marco, Orville, Marion, De Pastena, Matteo, Pietrabissa, Andrea, Poves, Ignaci, Primrose, John, Pugliese, Raffaele, Ricci, Claudio, Roberts, Keith, Røsok, Bård, Sahakyan, Mushegh A, Sánchez cabús, Santiago, Sandström, Per, Scovel, Lauren, Solaini, Leonardo, Soonawalla, Zahir, Souche, F. Régi, Sutcliffe, Robert P, Tiberio, Guido A, Tomazic, Aleš, Troisi, Roberto, Wellner, Ulrich, White, Steven, Wittel, Uwe A, Zerbi, Alessandro, Bassi, Claudio, Besselink, Marc G, Abu Hilal, Mohammed, Van Hilst, J., De Rooij, T., Klompmaker, S., Rawashdeh, M., Aleotti, F., Al-Sarireh, B., Alseidi, A., Ateeb, Z., Balzano, G., Berrevoet, F., Bjornsson, B., Boggi, U., Busch, O. R., Butturini, G., Casadei, R., Del Chiaro, M., Chikhladze, S., Cipriani, F., Van Dam, R., Damoli, I., Van Dieren, S., Dokmak, S., Edwin, B., Van Eijck, C., Fabre, J. -M., Falconi, M., Farges, O., Fernandez-Cruz, L., Forgione, A., Frigerio, I., Fuks, D., Gavazzi, F., Gayet, B., Giardino, A., Groot Koerkamp, B., Hackert, T., Hassenpflug, M., Kabir, I., Keck, T., Khatkov, I., Kusar, M., Lombardo, C., Marchegiani, G., Marshall, R., Menon, K. V., Montorsi, M., Orville, M., De Pastena, M., Pietrabissa, A., Poves, I., Primrose, J., Pugliese, R., Ricci, C., Roberts, K., Rosok, B., Sahakyan, M. A., Sanchez-Cabus, S., Sandstrom, P., Scovel, L., Solaini, L., Soonawalla, Z., Souche, F. R., Sutcliffe, R. P., Tiberio, G. A., Tomazic, A., Troisi, R., Wellner, U., White, S., Wittel, U. A., Zerbi, A., Bassi, C., Besselink, M. G., Abu Hilal, M., Graduate School, AGEM - Digestive immunity, AGEM - Endocrinology, metabolism and nutrition, AGEM - Re-generation and cancer of the digestive system, CCA - Cancer Treatment and Quality of Life, Surgery, APH - Methodology, Assistance publique - Hôpitaux de Paris (AP-HP) (APHP)-Université Paris Diderot - Paris 7 (UPD7)-Hôpital Beaujon, and CRLCC Val d'Aurelle - Paul Lamarque-Université de Montpellier (UM)-Institut National de la Santé et de la Recherche Médicale (INSERM)
Subjects: Male, [SDV]Life Sciences [q-bio], 030230 surgery, robot-assisted, laparoscopic, distal pancreatectomy, laparoscopic, left pancreatectomy, minimally invasive, robot-assisted, 0302 clinical medicine, Postoperative Complications, Pan european, Robotic Surgical Procedures, Medicine, distal pancreatectomy, Incidence, 3. Good health, Europe, Survival Rate, medicine.anatomical_structure, left pancreatectomy, Treatment Outcome, 030220 oncology & carcinogenesis, Female, Distal pancreatectomy, Pancreas, Cohort study, Carcinoma, Pancreatic Ductal, medicine.medical_specialty, Adenocarcinoma, Article, 03 medical and health sciences, Pancreatectomy, Carcinoma, Humans, Minimally Invasive Surgical Procedures, Ductal adenocarcinoma, Propensity Score, Aged, Neoplasm Staging, Retrospective Studies, business.industry, Retrospective cohort study, Length of Stay, medicine.disease, digestive system diseases, Surgery, Pancreatic Neoplasms, Propensity score matching, minimally invasive, Pàncrees -- Càncer -- Tractament, Laparoscopy, business
Abstract: International audience; OBJECTIVE: The aim of this study was to compare oncological outcomes after minimally invasive distal pancreatectomy (MIDP) with open distal pancreatectomy (ODP) in patients with pancreatic ductal adenocarcinoma (PDAC). BACKGROUND: Cohort studies have suggested superior short-term outcomes of MIDP vs. ODP. Recent international surveys, however, revealed that surgeons have concerns about the oncological outcomes of MIDP for PDAC. METHODS: This is a pan-European propensity score matched study including patients who underwent MIDP (laparoscopic or robot-assisted) or ODP for PDAC between January 1, 2007 and July 1, 2015. MIDP patients were matched to ODP patients in a 1:1 ratio. Main outcomes were radical (R0) resection, lymph node retrieval, and survival. RESULTS: In total, 1212 patients were included from 34 centers in 11 countries. Of 356 (29%) MIDP patients, 340 could be matched. After matching, the MIDP conversion rate was 19% (n = 62). Median blood loss [200?mL (60-400) vs 300?mL (150-500), P = 0.001] and hospital stay [8 (6-12) vs 9 (7-14) days, P \textless 0.001] were lower after MIDP. Clavien-Dindo grade >=3 complications (18% vs 21%, P = 0.431) and 90-day mortality (2% vs 3%, P \textgreater 0.99) were comparable for MIDP and ODP, respectively. R0 resection rate was higher (67% vs 58%, P = 0.019), whereas Gerota's fascia resection (31% vs 60%, P \textless 0.001) and lymph node retrieval [14 (8-22) vs 22 (14-31), P \textless 0.001] were lower after MIDP. Median overall survival was 28 [95% confidence interval (CI), 22-34] versus 31 (95% CI, 26-36) months (P = 0.929). CONCLUSIONS: Comparable survival was seen after MIDP and ODP for PDAC, but the opposing differences in R0 resection rate, resection of Gerota's fascia, and lymph node retrieval strengthen the need for a randomized trial to confirm the oncological safety of MIDP.
Published: 2019

17. Limited Induction of Tumor Cross-Reactive T Cells without a Measurable Clinical Benefit in Early Melanoma Patients Vaccinated with Human Leukocyte Antigen Class I–Modified Peptides

Author: Chiara Castelli, Marco Asioli, Paola Filipazzi, Claudia Lombardo, Michele Maio, Antonello Villa, Chiara Camisaschi, Riccardo Danielli, Gabrina Tragni, Gloria Sovena, Paola Frati, Gianluigi Rigamonti, Roberto Patuzzo, Licia Rivoltini, Paola Squarcina, Andrea Maurichi, Giorgio Parmiani, Agata Cova, Luigi Mariani, Felicetta Giardino, Annabella Di Florio, Lorenzo Pilla, Mario Santinami, Vanna Chiarion-Sileni, Filipazzi, P, Pilla, L, Mariani, L, Patuzzo, R, Castelli, C, Camisaschi, C, Maurichi, A, Cova, A, Rigamonti, G, Giardino, F, Di Florio, A, Asioli, M, Frati, P, Sovena, G, Squarcina, P, Maio, M, Danielli, R, Chiarion Sileni, V, Villa, A, Lombardo, C, Tragni, G, Santinami, M, Parmiani, G, and Rivoltini, L
Subjects: Cancer Research, T-Lymphocytes, medicine.medical_treatment, Epitopes, T-Lymphocyte, Human leukocyte antigen, Cross Reactions, Cancer Vaccines, MART-1 Antigen, Immune system, medicine, Humans, Melanoma, Neoplasm Staging, business.industry, Histocompatibility Antigens Class I, Cancer, tumor recognition, medicine.disease, Vaccination, Treatment Outcome, Oncology, Immunization, Case-Control Studies, Vaccines, Subunit, Immunology, Peptides, business, Immunologic Memory, Adjuvant, CD8
Abstract: Purpose: The progressive immune dysfunctions that occur in patients with advanced melanoma make them unlikely to efficiently respond to cancer vaccines. A multicenter randomized phase II trial was conducted to test whether immunization with modified HLA class I tumor peptides in the context of adjuvant therapy results in better immunologic responses and improved clinical outcomes in patients with early melanoma (stages IIB/C-III). Experimental Design: Forty-three patients were enrolled to undergo vaccination (n = 22) or observation (n = 21). The vaccine included four HLA-A*0201–restricted modified peptides (Melan-A/MART-1[27L], gp100[210M], NY-ESO-1[165V], and Survivin[97M]) emulsified in Montanide ISA51 and injected subcutaneously in combination with cyclophosphamide (300 mg/m2) and low-dose IL-2 (3 × 106 IU). The immune responses were monitored using ex vivo IFN-γ–ELISpot, HLA/multimer staining, and in vitro short-term peptide sensitization assays. Results: Vaccination induced a rapid and persistent increase in specific effector memory CD8+ T cells in 75% of the patients. However, this immunization was not associated with any significant increase in disease-free or overall survival as compared with the observation group. An extensive immunologic analysis revealed a significantly reduced cross-recognition of the corresponding native peptides and, most importantly, a limited ability to react to melanoma cells. Conclusions: Adjuvant setting is an appealing approach for testing cancer vaccines because specific CD8+ T cells can be efficiently induced in most vaccinated patients. However, the marginal antitumor activity of the T cells induced by modified peptides in this study largely accounts for the observed lack of benefit of vaccination. These findings suggest reconsidering this immunization strategy, particularly in early disease. Clin Cancer Res; 18(23); 6485–96. ©2012 AACR.
Published: 2012

18. Dry deposition models for radionuclides dispersed in air: a new approach for deposition velocity evaluation schema

Author: C. Lombardo, Antonio Cervone, Maddalena Casamirra, Pietro Buffa, Mariarosa Giardina, F. De Rosa, Giardina, M, Buffa, P, Cervone, A, De Rosa, F, Lombardo, C, and Casamirra, M
Subjects: History, Radionuclide, Physical model, 010504 meteorology & atmospheric sciences, Mathematical model, business.industry, Chemistry, Mechanical engineering, 01 natural sciences, 010305 fluids & plasmas, Computer Science Applications, Education, Research centre, Dry deposition, pollutant, radionuclides, deposition velocity, 0103 physical sciences, Process engineering, business, Settore ING-IND/19 - Impianti Nucleari, 0105 earth and related environmental sciences
Abstract: In the framework of a National Research Program funded by the Italian Minister of Economic Development, the Department of Energy, Information Engineering and Mathematical Models (DEIM) of Palermo University and ENEA Research Centre of Bologna, Italy is performing several research activities to study physical models and mathematical approaches aimed at investigating dry deposition mechanisms of radioactive pollutants. On the basis of such studies, a new approach to evaluate the dry deposition velocity for particles is proposed. Comparisons with literature experimental data show that the proposed dry deposition scheme allows to capture the main phenomena involved in the dry deposition process successfully
Published: 2017

19. Use of Intraperitoneal ePTFE Gore Dual-Mesh Plus in a Giant Incisional Hernia After Kidney Transplantation: A Case Report

Author: Maurizio Romano, Giuseppe Damiano, Maria Concetta Gioviale, A.I. Lo Monte, Giuseppe Buscemi, C. Lombardo, C. Maione, LO MONTE, AI, DAMIANO,G, MAIONE, C, GIOVIALE,MC, LOMBARDO, C, BUSCEMI, G, and ROMANO, M
Subjects: Male, medicine.medical_specialty, Incisional hernia, Lymphocele, medicine, Humans, Hernia, Kidney transplantation, Transplantation, incisional hernia,kidney transplantation,dual-mesh, business.industry, Middle Aged, Surgical Mesh, medicine.disease, Kidney Transplantation, Urinoma, Hernia, Abdominal, Surgery, Settore MED/18 - Chirurgia Generale, surgical procedures, operative, Surgical mesh, Tomography, X-Ray Computed, business, Abdominal surgery
Abstract: We evaluated the incidence of and predisposing factors for an incisional hernia after kidney transplantation. Numerous techniques have been used to repair postoperative fascial dehiscences or simple incisional hernias, but no clear treatment exists for giant hernias. Our aim was to obtain (1) a safe procedure to repair a large abdominal defect and reinforce the surrounding, fragile zones and (2) a simple, rapid technique to reduce the operative time. Herein we have described the surgical repair of a giant incisional hernia using intraperitoneal Gore ePTFE dual-mesh plus (Gore-Tex; W. L. Gore, Flagstaff, Ariz, USA) in a 55-year-old man status-post renal transplantation. Total necrosis of distal graft ureter had caused a giant urinoma. The patient was reexplored on day 2 posttransplantation with a primary fascial approximation. Thirty days after transplantation we discovered a large incisional hernia and performed a repair. No drain was used. The patient continued immunosuppressive therapy (cyclosporine, mycophenolate mofetil, prednisolone) and was discharged on postoperative day 4 with no complications. An ultrasonographic follow-up at 1 year revealed the prosthesis to be correctely positioned. Incisional hernia is not rare after renal transplantation but the real incidence is unknown. Immunosuppressive therapy, prolonged pretransplantation dialysis, obesity, and diabetes are probably the major causes of incisional hernias in these patients. Surgical complications of renal transplantation surgery, such as wound hematoma, urinoma, and lymphocele, are the most important predisposing factors for an incisional hernia. The use of intraperitoneal ePTFE dual-mesh is feasible, safe, and easy to repair a large incisional hernia in a kidney transplant patient.
Published: 2009

20. Bone Resorption in Kidney Transplant Recipients

Author: Giuseppe Buscemi, C. Lombardo, Giuseppe Damiano, C. Maione, A.I. Lo Monte, Maria Concetta Gioviale, GIOVIALE, MC, DAMIANO, G, LOMBARDO, C, MAIONE, C, BUSCEMI, G, and LO MONTE, AI
Subjects: Adult, Male, medicine.medical_specialty, Deoxypyridinoline, Urology, Collagen Type I, Bone resorption, Bone remodeling, chemistry.chemical_compound, Internal medicine, medicine, Humans, Osteodystrophy, Amino Acids, Bone Resorption, Aged, Transplantation, Creatinine, Hyperparathyroidism, Pyridinoline, business.industry, hyperparathyroidism, kidney transplantation, urinary cross-links, Middle Aged, Alkaline Phosphatase, medicine.disease, Kidney Transplantation, Transplant Recipients, Settore MED/18 - Chirurgia Generale, Endocrinology, chemistry, Female, Surgery, business, Biomarkers
Abstract: Early diagnosis of persistent hyperparathyroidism (HP) following kidney transplantation may prevent worsening of osteodystrophy and potential damage to the graft. We evaluated the utility of collagen pyridinoline (PYD) and deoxypyridinoline (DPD) urinary cross-links beyond the common HP markers to evaluate 70 selected stable recipients between 1997 and 2006 who were divided into 2 group depending on the immunosuppressive protocol. All patients showed elevated levels of urinary cross-links even though calcemia and phosphoremia values were normal. Their mean creatinine level was slightly increased. Data were assessed as mean values +/- SD. All variables underwent a correlation matrix analysis and a stepwise regression, with posttransplant intact parathyroid hormone (iPTH) as the dependent variable and other variables as regressors. A statistically significant correlation was observed between PYD and alkaline phosphatase (ALP; P = .0026, r = .41); PYD and DPD (P = .015, r = .34); pre- and posttransplant iPTH (P = .024, r = .31); and creatinine and ALP (P = .024, r = .31). Taking the groups separately, there were significant correlations between PYD and ALP (P = .0076, r = .42); PYD and DPD (P = .017, r = .38); ALP and posttransplant iPTH (P = .038, r = .33); osteocalcin (OC) and posttransplant iPTH (P = .048, r = .32); and pre- and posttransplant iPTH (P = .019, r = .37) among subjects in the first group, whereas subjects in the second group showed a correlation between posttransplant iPTH and age at transplantation (P = .032, r = .61). In conclusion, we showed that urinary cross-links may be helpful to reveal bone resorption in kidney recipients when usual bone metabolism parameters do not demonstrate hyperparathyroidism.
Published: 2009

21. Transient analysis of '2 inch Direct Vessel Injection line break' in SPES-2 facility by using TRACE code

Author: S D'Amico, I. Moscato, M Polidori, C Lombardo, Giuseppe Vella, Polidori, M., and Lombardo, C.
Subjects: Nuclear power plants -- Design and construction, History, Engineering, Mathematical models, business.industry, Numerical analysis, Nuclear engineering, System safety, Computer Science Applications, Education, law.invention, law, Nuclear power plant, Code (cryptography), Nuclear power plants -- Safety measures, Transient (oscillation), business, Simulation, Electronic circuit, TRACE (psycholinguistics), Line Break
Abstract: In the past few decades a lot of theoretical and experimental researches have been done to understand the physical phenomena characterizing nuclear accidents. In particular, after the Three Miles Island accident, several reactors have been designed to handle successfully LOCA events. This paper presents a comparison between experimental and numerical results obtained for the “2 inch Direct Vessel Injection line break” in SPES-2. This facility is an integral test facility built in Piacenza at the SIET laboratories and simulating the primary circuit, the relevant parts of the secondary circuits and the passive safety systems typical of the AP600 nuclear power plant. The numerical analysis here presented was performed by using TRACE and CATHARE thermal-hydraulic codes with the purpose of evaluating their prediction capability. The main results show that the TRACE model well predicts the overall behaviour of the plant during the transient, in particular it is able to simulate the principal thermal-hydraulic phenomena related to all passive safety systems. The performance of the presented CATHARE noding has suggested some possible improvements of the model., peer-reviewed
Published: 2015

22. Report from the OECI Oncology days 2014

Author: F Paparo, F Lemare, Darius Razavi, P De Paoli, PA Cadariu, F. De Lorenzo, Johannes Haybaeck, GA Rollandi, Gunnar Folprecht, Giovanni Bussolati, Peter Riegman, JA López Guerrero, Giorgio Stanta, T Ciuleanu, Marco A. Pierotti, Claudio Lombardo, József Lövey, S Zupo, R Buiga, W.H. van Harten, Mauro Truini, A Bagg, M Dono, Karl-Friedrich Becker, Gerald Hoefler, Mahasti Saghatchian, N. Goedbloed, G Weiner, Health Technology & Services Research, Faculty of Behavioural, Management and Social Sciences, van Harten, W, Stanta, Giorgio, Bussolati, G, Riegman, P, Hoefler, G, Becker, K, Folprecht, G, Truini, M, Haybaeck, J, Buiga, R, Dono, M, Bagg, A, López Guerrero, J, Zupo, S, Lemare, F, de Lorenzo, F, Goedbloed, N, Razavi, D, Lövey, J, Cadariu, P, Rollandi, G, Paparo, F, Pierotti, M, Ciuleanu, T, De Paoli, P, Weiner, G, Saghatchian, M, Lombardo, C., and Pathology
Subjects: Oncology, Cancer Research, medicine.medical_specialty, Designation, organisation, comprehensive cancer centres, designation, accreditation, personalized medicine, Comprehensive cancer centres, Accreditation, Environnement et pollution, Clinical decision making, SDG 3 - Good Health and Well-being, Internal medicine, IR-97320, medicine, Tumor biopsy, METIS-311886, business.industry, comprehensive cancer centre, Cancer survival, Conference Report, Personalized medicine, Health care delivery, Cancérologie, Organisation, Cancer Radiotherapy, Day hospital, business
Abstract: The 2014 OECI Oncology Days was held at the 'Prof. Dr. Ion Chiricuta' Oncology Institute in Cluj, Romania, from 12 to 13 June. The focus of this year's gathering was on developments in personalised medicine and other treatment advances which have made the cost of cancer care too high for many regions throughout Europe., SCOPUS: ar.j, info:eu-repo/semantics/published
Published: 2014

23. An old method for good new cells

Author: A.I. Lo Monte, Maria Concetta Gioviale, C. Lombardo, Giuseppe Damiano, DAMIANO, G, GIOVIALE, MC, LOMBARDO, C, and LO MONTE, AI
Subjects: Male, Pathology, medicine.medical_specialty, Adenosine, Cell Survival, Allopurinol, Antigens, CD19, Organ Preservation Solutions, viable cells,micro-surgical in-situ perfusion,pancreas,after exsanguination, Raffinose, medicine, Animals, Ficoll, Insulin, Viaspan, Aorta, Abdominal, Rats, Wistar, Pancreas, Transplantation, business.industry, Left Common Iliac Artery, Glutathione, Perfusion, Settore MED/18 - Chirurgia Generale, medicine.anatomical_structure, Ficoll gradient, Female, Surgery, business
Abstract: The aim of this work was to demonstrate a greater number of viable cells using a micro-surgical in-situ perfusion to collect rat pancreata compared with the pancreas after exsanguination. We used 3 groups of 20 rats. Perfusion was performed by selective cannulation of the left common iliac artery with administration of UW solution at 4 degrees C. Collected pancreata were digested and cells separated by Ficoll gradient were placed in culture to permit adhesion to dishes. Cells were characterized and tested for viability. We observed a gain of about 14% in the number of viable cells compared with those obtained after exsanguination (P < .001 by chi-square).
Published: 2009

24. Physics potential of the Jiangmen underground neutrino observatory

Author: Giuseppe Verde, Salvatore Costa, Antonio Insolia, Marco Fargetta, Riccardo Bruno, Nunzio Giudice, Salvatore Monforte, Giuseppe Andronico, Rossella Caruso, Cristina Tuve, M. Buscemi, Nunzio Guardone, Sebastiano Aiello, Claudio Lombardo, Lombardo C., Caruso R., Costa S., Insolia A., Tuve C., Giudice N., Guardone N., Buscemi M., Andronico G., Aiello S., Bruno R., Fargetta M., Monforte S., and Verde G.
Subjects: Physics, Physics::Instrumentation and Detectors, business.industry, Astrophysics::High Energy Astrophysical Phenomena, Solar neutrino, Settore FIS/01 - Fisica Sperimentale, High Energy Physics::Phenomenology, Astronomy, Flux, Nuclear power, neutrino, Supernova, Observatory, High Energy Physics::Experiment, Neutrino, business, Neutrino oscillation, Jiangmen Underground Neutrino Observatory
Abstract: JUNO (Jiangmen Underground Neutrino Observatory) is a 20 kton multipurpose neutrinodetector under construction in China and it will be completed in 2021. The detector will belocated near the the city of Jiangmen, 53 km away from two nuclear power plants that willprovide the neutrino flux for the main sear of the observatory. The main physics goal is the determination of the neutrino Mass Hierarchy, even if will play animportant also in other topics, such as: neutrino oscillation, solar neutrino, SuperNova neutrinos,geoneutrinos and atmosperic neutrinos among others

25. The use of a new kind of low profile retractor for arteriovenous fistula procedure simplifies and speeds up the intervention

Author: Giuseppe Amato, C. Lombardo, Giuseppe Damiano, Maurizio Romano, A.I. Lo Monte, Giorgio Romano, Maria Concetta Gioviale, LO MONTE, AI, AMATO, G, DAMIANO, G, GIOVIALE, MC, LOMBARDO, C, ROMANO,G, and ROMANO, M
Subjects: medicine.medical_specialty, Time Factors, medicine.medical_treatment, 030232 urology & nephrology, Arteriovenous fistula, arterioveunous fistula, retractors, 030204 cardiovascular system & hematology, 03 medical and health sciences, Arteriovenous Shunt, Surgical, 0302 clinical medicine, Operating time, Humans, Medicine, Patient group, Disposable Equipment, Reduction (orthopedic surgery), Brachiocephalic Veins, Retrospective Studies, Surgical team, Surgical instrumentation, Surgical Fixation Device, business.industry, Equipment Design, Surgical Instruments, medicine.disease, arteriovenous fistula,ReeTrakt system, Surgery, Retractor, Forearm, Settore MED/18 - Chirurgia Generale, Treatment Outcome, Nephrology, Radial Artery, business
Abstract: Purpose The aim of this study was to demonstrate the effectiveness of a new kind of disposable surgical retractor in arteriovenous fistula (AVF) procedures in order to achieve an easier, faster and safer surgical intervention. Methods Between January and June 2008, 22 AVF procedures were performed using the 3PAWS ReeTrakttrade; (Insightra Inc. - Irvine, Ca., USA) a self-retaining, low profile retractor. An equivalent patient sample, in which an AVF was performed using conventional retraction devices, was considered for comparison of the intra- and post-operative results. Results In all of the 22 AVF procedures performed, the ReeTrakt™ system has simplified the performance of the surgical team. The retractors were very easy to place. The view of the operating field was always optimal. The introduction of the surgical instruments was at all times extremely easy and unrestricted. We also noted a reduction in the operating time (from an average of 67 min in controls to 43 min). There were no intraoperative complications. No post-operative complications related to the use of this kind of device occurred. Conversely, the amount of intra- and post-operative complications in the control group managed with conventional retraction devices was marginally higher than in the ReeTrakt™ patient group. Conclusion The ReeTrakt™ system is a very simple and useful low profile retractor for AVF procedures. Its ultra low profile allows a much improved view of the operating field, an unhindered insertion of the surgical instruments and a shortening of intervention time, avoiding the problems which arise as a result of standard retractors typically used during this kind of procedure. Due to absolute perpendicular retraction it offers a highly atraumatic performance, avoiding swelling and marks on the insertion sites. Therefore, in our opinion, it has the potential to reduce the risk of wound oedema, hematomas or infection associated with the AVF procedure. This is important as many patients are elderly with fragile tissues.

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25 results on '"Lombardo C"'

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25. The use of a new kind of low profile retractor for arteriovenous fistula procedure simplifies and speeds up the intervention

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