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The Italian START-Register on anticoagulation with focus on atrial fibrillation
- Source :
- PLoS ONE, Vol 10, Iss 5, p e0124719 (2015), PLoS ONE
- Publication Year :
- 2015
- Publisher :
- Public Library of Science, 2015.
-
Abstract
- START-Register - Survey on anTicoagulated pAtients RegisTer - is an independent, inception-cohort, observational, collaborative database aimed at recording prospectively the clinical history of adult patients starting anticoagulant treatment for any reason and using whatever drug. In this article we present the START-Register and give cross section baseline data focusing on non valvular atrial fibrillation (NVAF). Participants are asked to insert prospectively consecutive patients recorded as electronic file on the web-site of the registry. Required data are: demographic and clinical characteristics of patients, associated risk factors for stroke and bleeding, laboratory routine data, clinical indication for treatment, expected therapeutic range (in cases of treatment with vitamin K antagonists -VKAs). The follow-up is carried out to record: quality of treatment (for patients on VKAs), bleeding complications, thrombotic events, and the onset of any type of associated disease. To date 5252 patients have been enrolled; 97.6% were on VKAs because direct oral anticoagulants (DOAC) have been available in Italy only recently. The median age was 74 years [interquartile range (IQR) 64-80]; males 53.7%. This analysis is focused on the 3209 (61.1%) NVAF patients. Mean CHADS2 score was 2.1±1.1, CHADSVASc score was 3.1±1.3;median age was 76 years (IQR 70-81); 168 patients (5.3%) had severe renal failure [Creatinine clearance (CrCl) 80 years with high prevalence of renal failure.
- Subjects :
- Genetics and Molecular Biology (all)
Male
medicine.medical_specialty
lcsh:Medicine
Renal function
Hemorrhage
Biochemistry
Atrial Fibrillation, coagulation, anticoagulation
Cohort Studies
chemistry.chemical_compound
Interquartile range
Risk Factors
Internal medicine
Atrial Fibrillation
medicine
80 and over
Humans
Registries
Renal Insufficiency
lcsh:Science
Stroke
Aged
Aged, 80 and over
Creatinine
Multidisciplinary
business.industry
Anticoagulants
Female
Italy
Middle Aged
Medicine (all)
lcsh:R
Atrial fibrillation
medicine.disease
Surgery
Clinical trial
Agricultural and Biological Sciences (all)
chemistry
Biochemistry, Genetics and Molecular Biology (all)
lcsh:Q
Observational study
business
Research Article
Cohort study
Subjects
Details
- Language :
- English
- Database :
- OpenAIRE
- Journal :
- PLoS ONE, Vol 10, Iss 5, p e0124719 (2015), PLoS ONE
- Accession number :
- edsair.doi.dedup.....26812e5128a67773e175cb87543fc62d