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The article discusses if AIDS is an epidemic form of African Kaposi's (KS) sarcoma. The researcher stresses that it has been presumed that it is a new disease, appearing de novo in the U.S. in 1979. In this paper, the hypothesis is made that KS in Africa is a sexually-transmitted infectious disease that is disperse predominantly by male homosexual intercourse, and that the cause of AIDS is also the factor responsible for African KS, introduced into a susceptible population.

The article discusses the controversy regarding the origins of the AIDS viruses, HIV-1 and HIV-2. According to some theories and explanation, HIV-1 and HIV-2 are ancient human viruses originated in central and west Africa which spread throughout Europe. In addition, it is plausible that AIDS epidemic started through a hostile power in 1970 in the U.S.

In Africa, the burden of hypertension has been rising at an alarming rate for the last two decades and is a major cause for cardiovascular disease (CVD) mortality and morbidity. Hypertension is characterised by elevated blood pressure (BP) ≥ 140/90 mmHg. Current hypertension guidelines recommend the use of antihypertensives belonging to the following classes: calcium channel blockers (CCB), angiotensin converting inhibitors (ACEI), angiotensin receptor blockers (ARB), diuretics, β-blockers, and mineralocorticoid receptor antagonists (MRAs), to manage hypertension. Still, a considerable number of hypertensives in Africa have their BP uncontrolled due to poor drug response and remain at the risk of CVD events. Genetic factors are a major contributing factor, accounting for 20% to 80% of individual variability in therapy and poor response. Poor response to antihypertensive drug therapy is characterised by elevated BPs and occurrence of adverse drug reactions (ADRs). As a result, there have been numerous studies which have examined the role of genetic variation and its influence on antihypertensive drug response. These studies are predominantly carried out in non-African populations, including Europeans and Asians, with few or no Africans participating. It is important to note that the greatest genetic diversity is observed in African populations as well as the highest prevalence of hypertension. As a result, this warrants a need to focus on how genetic variation affects response to therapeutic interventions used to manage hypertension in African populations. In this paper, we discuss the implications of genetic diversity in CYP11B2, GRK4, NEDD4L, NPPA, SCNN1B, UMOD, CYP411, WNK, CYP3A4/5, ACE, ADBR1/2, GNB3, NOS3, B2, BEST3, SLC25A31, LRRC15 genes, and chromosome 12q loci on hypertension susceptibility and response to antihypertensive therapy. We show that African populations are poorly explored genetically, and for the few characterised genes, they exhibit qualitative and quantitative differences in the profile of pharmacogene variants when compared to other ethnic groups. We conclude by proposing prioritization of pharmacogenetics research in Africa and possible adoption of pharmacogenetic-guided therapies for hypertension in African patients. Finally, we outline the implications, challenges, and opportunities these studies present for populations of non-European descent. [ABSTRACT FROM AUTHOR]

The human immunodeficiency viruses are two species of Lentivirus that infect humans. Over time, they cause acquired immunodeficiency syndrome, a condition in which progressive immune system failure allows life-threatening opportunistic infections and cancers to thrive. Human immunodeficiency virus infection came from a type of chimpanzee in Central Africa. Studies show that immunodeficiency viruses may have jumped from chimpanzees to humans as far back as the late 1800s. Over decades, human immunodeficiency viruses slowly spread across Africa and later into other parts of the world. The Susceptible-Infected-Recovered (SIR) models are significant in studying disease dynamics. In this paper, we have studied the effect of irresponsible immigrants on HIV/AIDS dynamics by formulating and considering different methods. Euler, Runge Kutta, and a Non-standard finite difference (NSFD) method are developed for the same problem. Numerical experiments are performed at disease-free and endemic equilibria points at different time step sizes 'h'. The results reveal that, unlike Euler and Runge Kutta, which fail for large time step sizes, the proposed Non-standard finite difference (NSFD) method gives a convergence solution for any time step size. Our proposed numerical method is bounded, dynamically consistent, and preserves the positivity of the continuous solution, which are essential requirements when modeling a prevalent disease. [ABSTRACT FROM AUTHOR]

This paper explores ethical considerations for active studies of circumcision, i.e., the amputation of the foreskin, in the form of a case study of three major trials performed in African countries in the early 2000s. The paper outlines the function of the foreskin and method and history of its amputation as well as its current use in attempting to combat the global AIDS crisis. These trials are then interrogated in accordance with the Declaration of Helsinki. In particular, the irreversible nature of amputation is given great consideration. The case studies are found to have serious failures in terms of the modern iteration of the Declaration of Helsinki. This paper calls for extreme scrutiny in accordance with international norms relating to the ethical treatment of human subjects in a research context of studies of circumcision if and when they are proposed again. [ABSTRACT FROM AUTHOR]

Introduction: We sought to examine the association between livelihood security and adherence to antiretroviral therapy (ARVs) in low- and middle-income countries (LIMC). Methods: Performing a systematic review, we searched, independently and in duplicate, 7 electronic databases and 2 conference websites for quantitative surveys that examined the association between indicators of livelihood security and adherence to ARVs in LIMC between 2000-2010. Criteria for relevance were applied to complete papers (quantitative study with estimates of associations) and quality assessment was conducted on those deemed relevant. We performed three regressions to measure the association between each type of livelihood and adherence. Results: Twenty original studies and 6 conference abstracts were included, the majority from Africa (n = 16). Seventeen studies and 3 conference abstracts were cross-sectional and 3 studies and 3 abstracts were prospective clinical cohort studies, with considerable variation in quality for studies of each design type. Among the diverse populations represented, we observed considerable variation in associations between measurements of livelihood indicators and increasingly accepted adherence measures, irrespective of study design or quality. A financial capital indicator, financial constraints/payment for ARV medication, was more commonly associated with non-adherence (3/5 studies). A human capital indicator, educational level, was most commonly associated with adherence (11/20 studies). Discussion: Additional better quality research examining livelihood security is required to inform provision of optimal supports for adherence and mitigation of the impacts of HIV/AIDS. [ABSTRACT FROM AUTHOR]

HIV/AIDS is the major threat to development, economic growth and poverty alleviation in much of Africa. And yet the full extent of the catastrophe facing the continent is only just being recognized, and still not by all. The international development targets set by the great and the good of the global community--or at least by those members of the community who attend the international summits that set these goals--do not consider what HIV/AIDS means and are unachievable. This paper begins by setting the scene, describing the epidemic, explaining why it is so important and what makes HIV/AIDS different. It then explores how the poverty/epidemic cycle works, whereby poverty increases the spread of HIV and AIDS increases poverty. It suggests we need to look beyond monetary poverty to understand these relationships. Finally the paper assesses what can and should be done to break the HIV/AIDS poverty cycle. [ABSTRACT FROM AUTHOR]

Sub-Saharan Africa is the part of the world that is most severely affected by HIV/AIDS. Yet, surveys of attitudes to AIDS across African countries show that voters do not attach great importance to the issue. This paper argues that the low salience of AIDS is in large part a result of the widespread poverty that exists on the continent, which means that AIDS is crowded out by other issues. Using multilevel regressions, results from four waves of survey data support the hypothesis that poverty significantly affects the salience of AIDS as a political issue at the individual level. [ABSTRACT FROM PUBLISHER]

The Food and Agriculture Organization states that ‘the most affected African countries could lose up to 26% of their agricultural labor force within two decades. As agriculture still represents a large proportion of the gross domestic product, this loss in labor could have severe impacts on national economies’ (FAO). Yet, the two quantitative studies presented indicate that the impacts are not only difficult to measure, but that they may be less significant than might be expected when considered at the aggregate level of community (Jayne et al.; Dorward, Mwale, and Tuseo). Importantly, both authors also caution against the potentially spurious conclusion that under scenarios of minimal aggregate impact, households would also remain largely unaffected by HIV/AIDS. This paper discusses the key findings of these two studies and highlights the gaps in the knowledge base and the methodological challenges of conducting research of this kind. [ABSTRACT FROM AUTHOR]

The article cites studies that analyze the relation of orphanhood to the occurrence of human immunodeficiency virus (HIV)/AIDS in Africa. One paper draws upon an exceptional Tanzanian two-period data set. This data set may illuminate on the effects of orphanhood on human capital formation. Another issue refers to the cost of orphanhood to an economy over time, or the trade-off between allocating resources to mitigate the negative effects of orphanhood directly and investing in HIV/AIDS mitigation. It is found that HIV/AIDS can have a large negative impact on total factor productivity.

This study offers an alternative method rooted in GIS techniques and spatial analysis to estimate HIV/AIDS prevalence over space from an incomplete surveillance data set and explain the variation of those estimates. The results clearly show that the HIV/AIDS epidemic is complex and that it is interconnected with other geographic, historical, economic and cultural phenomena which help explain its spatial spread and variation. The regression models which were developed in this paper illustrated that variables which measure the historical context of colonialism such as resource exploitation and labor migration, gender, culture, contemporary global forces, poverty and disease burden have all contributed variously to the rapid spread of this disease both in space and time. The policy implication is that concentrating on behavior change or therapy alone may not turn the epidemic around. The attack needs to be multifaceted and interdisciplinary taking into consideration the context and the economic and social realities at multiple spatial scales. [ABSTRACT FROM AUTHOR]

Copyright of Journal of Women's Entrepreneurship & Education is the property of Institute of Economic Sciences and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)

Copyright of Culture, Health & Sexuality is the property of Routledge and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)

Copyright of Culture, Health & Sexuality is the property of Routledge and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)

Simple Summary: Following infection with HIV, individuals are immunocompromised. Their weakened immune system puts them at a higher risk of certain cancers like Kaposi sarcoma and lymphoma. Even with antiretroviral therapy for HIV infection, these cancers remain common in developing countries, while in developed countries, there is a decline in some cancers but an increase in deaths from others. This review explores why these cancers happen in people with HIV and finds that the current treatment is not enough to prevent them. Understanding these reasons is crucial to improving the diagnosis and treatment of both HIV and its associated cancers, highlighting the need for more research to tackle this ongoing health issue. The immune deficiency associated with human immunodeficiency virus (HIV) infection causes a distinct increased risk of developing certain cancer types. Kaposi sarcoma (KS), invasive cervical cancer and non-Hodgkin's lymphoma (NHL) are the prominent malignancies that manifest as a result of opportunistic viral infections in patients with advanced HIV infection. Despite the implementation of antiretroviral therapy (ART), the prevalence of these acquired immunodeficiency syndrome (AIDS)-defining malignancies (ADMs) remains high in developing countries. In contrast, developed countries have experienced a steady decline in the occurrence of these cancer types. However, there has been an increased mortality rate attributed to non-ADMs. Here, we provide a review of the molecular mechanisms that are responsible for the development of ADMs and non-ADMs which occur in HIV-infected individuals. It is evident that ART alone is not sufficient to fully mitigate the potential for ADMs and non-ADMs in HIV-infected individuals. To enhance the diagnosis and treatment of both HIV and malignancies, a thorough comprehension of the mechanisms driving the development of such cancers is imperative. [ABSTRACT FROM AUTHOR]

The US budget for global health funding, which was by far the largest of similar funding in the world, increased from US $1.3 billion in 2001 to more than US $10 billion in recent years. More than 54% of this funding was allocated to the Global Fund to Fight HIV/AIDS through the US President's Emergency Plan for AIDS Relief (PEPFAR) in Africa. However, recent studies indicate contradictory results regarding the effectiveness of PEPFAR. One by Bendavid, Holmes, Bhattacharya, and Miller shows positive effects of PEPFAR in reducing adult mortality in Africa, while another by Duber, Coates, Szekeras, Kaji, and Lewis finds that there are no significant differences in reducing adult mortality in countries that received PEPFAR funding vs countries that did not. Due to their potential impact on policy decisions regarding critical global health funding, we wanted to assess why the results are discrepant. To do this, we replicated the Bendavid study. The replication provides verification that the study replicable and that the analytic choices of the authors are robust to different assumptions or restrictions. This allows us to assess the different choices and data available to the two research groups and draw some conclusions about why the results may be different. Then, focusing on two of the prominently discrepant studies, i.e., the Bendavid study (1998–2008) and the Duber study (2000–2006), we establish why the two studies are in disagreement. We apply appropriate individual-level and country-level analytical methodology as used by Bendavid over the analytical time period used for the Duber study (2000–2006), which originally focused on nationally aggregated data and differed in some key focus countries. For our first objective, we replicated the original Bendavid study findings and our findings support their conclusion that between 1998–2008 all-cause mortality decreased significantly more (OR = 0.84, CI, 0.72–0.99) in countries that implemented PEPFAR. For our second objective (Bendavid's data and methodology applied to Duber's study period), we found reduction in all cause adult mortality to be borderline insignificant (OR = 0.87 CI, 0.75–1.01, p = 0.06), most possibly reflecting the abbreviated fewer number of events and sample size over a shorter period. Therefore, our overall analyses are consistent with the conclusion of positive impact of the PEPFAR program in reducing adult mortality. We believe that the discrepancy observed in the original studies mainly a reflection of shortcomings in the analytical approach necessitated by the Duber study's nationally aggregated dataset or "may reflect a lack of data quality" in the Duber study (Duber, et al. 2010). [ABSTRACT FROM AUTHOR]

Background On the back of its recent economic development and domestic success in the fight against HIV/AIDS, Brazil is helping the Government of Mozambique to set up a pharmaceutical factory as part of its South-South cooperation programme. Until recently, a consensus existed that pharmaceutical production in Africa was not viable or sustainable. This paper looks into practicalities and evolution of this collaboration to illustrate the characteristics of Brazilian development cooperation in health, with the aim of drawing lessons for the wider debate on aid and local production of pharmaceuticals in Africa. Discussion We show that the project process has been very long and complex, has involved multiple public and private partners, and cost in excess of USD34 million. There have also been setbacks in the process, and although production has already started, it is unclear whether all the project's original objectives will be met. Summary The Brazil-Mozambique's pharmaceutical factory experience illustrates positives as well as limitations of Brazil's unorthodox approach to health development cooperation, highlighting its contribution to pushing the boundaries of the debate on local production of pharmaceuticals in resource-poor settings. [ABSTRACT FROM AUTHOR]

We investigate the relationship between HIV, marriage and nonmarital sexual activity, with a focus on adolescent behaviors. We use data from 45 Demographic and Health Surveys to examine how adolescent behavior among women born from 1958 to 1965 are related to the subsequent spread of HIV over time. These women were adolescents during the early 1980s, a time when HIV had started to spread but the cause was still unknown. We find that areas with currently high HIV rates had greater female education and more premarital sexual activity in the cohorts that came of age before HIV was understood. [ABSTRACT FROM AUTHOR]

Abstract: This paper addresses the interactions between the AIDS epidemic and climate change in southern Africa, particularly as they impact on food security. An assessment was undertaken through a comprehensive literature review. Understanding the underlying causes of regional food insecurity inevitably means understanding the role of the AIDS epidemic and increasingly climate change amongst other stressors. AIDS cuts through household and community level capacity, as well as the capacity of key facilitators of the adaptation process including state extension services and civil society organisations. The main argument of the paper is that adaptation to climate change must explicitly factor in the existing and long-term effects of the epidemic. While calls for embracing adaptation abound, little is being done to assess and strengthen the organisational capacity of institutions, which should play leading roles in any attempt to help prepare for a changing climate. In particular the capacity of key agencies has been undermined by the AIDS epidemic. This reiterates the need for a multisectoral approach and building bridges between agriculture and health sectors to ensure longer term support to livelihoods where HIV and hunger coexist, often overlaid by climate change. [ABSTRACT FROM AUTHOR]

Estimated worldwide deaths caused by HIV/AIDS total approximately 25 million. This epidemic has harmed the African continent in numerous ways and has profoundly changed its demographic profile. Globally, women who are most physiologically and socially vulnerable to infections are devastatingly affected by it. The President's Emergency Plan for AIDS Relief, launched by the administration of President George W. Bush, was the largest U.S. investment in any disease;however, its strategies were flawed by its failure to coordinate efforts with other global partners and to engage local indigenous organizations. This paper examines the impact of HIV/AIDS on women and children in sub-Saharan Africa and reviews the U.S. response to this epidemic. [ABSTRACT FROM AUTHOR]

An essay is presented on a review of several books related to HIV/AIDS in Africa. These books include "African Women's Unique Vulnerabilities to HIV/AIDS: Communication Perspectives and Promises," by Linda K. Fuller, "Twenty-Eight Stories of AIDS in Africa," by Stephanie, and "AIDS, Sex, and Culture: Global Politics and Survival in Southern Africa," by Ida Susser. The author stresses the aspect of prevention and biomedical treatment as a means of controlling the said human disease pandemic.

An introduction to the issue is presented which discusses Christianity and AIDS in Africa, an article on the messages of churches about HIV/AIDS, and faith based organizations and non-governmental organizations in Africa.

Copyright of Culture, Health & Sexuality is the property of Routledge and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)

Background: In the present paper, we consider the impact of HIV/AIDS on human development in African countries, showing that, beyond health issues, this disease should and must be seen as a global development concern, affecting all components of human development. Consequently, we stress the necessity of multidisciplinary approaches that model, estimate and predict the real impact of HIV/AIDS on human development of African countries in order to optimise the strategies proposed by national countries, international institutions and their partners. Methods: In our search strategy, we relied on secondary information, mainly through National Human Development Reports of some African countries and regular publications released by the United Nations (UN), United Nations Development Programme (UNDP), World Health Organization (WHO) and the World Bank. We restricted ourselves to reports dealing explicitly with the impact of HIV/AIDS on human development in African countries. Results and discussion: HIV/AIDS is affecting the global human development of African countries through its devastating impact on health and demographic indicators such as life expectancy at birth, healthcare assistance, age and sex distribution, economic indicators like income, work force, and economic growth, education and knowledge acquisition and other indicators like governance, gender inequality and human rights. Conclusion: On the basis of the national reports reviewed, it appears clearly that HIV/AIDS is no longer a crisis only for the healthcare sector, but presents a challenge to all sectors. Consequently, HIV/AIDS is a development question and should be viewed as such. The disease is impeding development by imposing a steady decline in the key indicators of human development and hence reversing the social and economic gains that African countries are striving to attain. Being at the same time a cause and consequence of poverty and underdevelopment, it constitutes a challenge to human security and human development by diminishing the chances of alleviating poverty and hunger, achieving universal primary education, promoting gender equality, reducing child and maternal mortality, and ensuring environmental sustainability. [ABSTRACT FROM AUTHOR]

Studies of female sexuality in Africa tend to adopt an instrumental approach, many times problematizing sexual conduct in relation to HIV infection and/or reproduction. This study aimed to explore sexuality as a relational concept. Using interviews and participant observation, the paper shows how sexuality becomes a point of self-identification for young professional women in Nairobi between 20 and 30 years-old. These women form a group who implicitly and explicitly criticize conventional gender roles through the overt pursuit of sexual pleasure as recognition of their womanhood. This aspect of the feminine sense of self is at odds with normative notions of femininity. To avoid criticism for being ‘un-proper’, women adopt a deferential attitude towards men. The focus on upwardly mobile professional women and their experiments with new types of heterosexual relations in dating provides insight into both sexuality and gender. [ABSTRACT FROM AUTHOR]

This paper proposes a procedure of parameter estimation for all parameters of the three-dimensional HIV model. The least square based procedure uses standard optimization routines to allow parameter extraction for individual patients. It is shown how additional information from outside a measurement dataset can be included in the estimation routine to increase the reliability And accuracy of parameter estimates. A dataset from 44 patients of Southern Africa is analyzed to find the set point and the time until set point for these patients together with an estimate of the model parameters with confidence intervals for the cohort The procedure is also applied to a long-term dataset of the HIV/AIDS progression to find possible variations in parameters. [ABSTRACT FROM AUTHOR]

The HIV epidemic in Africa has changed over the last decade and the incidence of AIDS, which was very low at the beginning of nineties, is now dramatically increasing. In this paper, we analyze the current situation of AIDS epidemiology on the continent, based on data generated by the antenatal care surveillance systems. As described here, the spread and prevalence of HIV differ in each African country, with South Africa now facing the worst situation. In addition, we have focused our attention on the modes and risks of viral transmission, highlighting the spread of HIV in particular subpopulations, which, for different reasons, prove to be more affected by the epidemic, such as sex workers and children. Genotype evolution and distribution in the various geographical areas are also considered. From this brief overview, it appears clear that poverty, the lack of technologies and inadequate resources, due mostly to social and economic instability, are widening the already existent gap between Africa and industrialized countries. [ABSTRACT FROM AUTHOR]

Using the conceptual framework of social reproduction as a way of reassessing the AIDS crisis in Africa, this paper finds contradictory tendencies: a devastating impact on agricultural modes of livelihood which sustain the majority and which enable workers to present themselves as cheap labour, but also a crisis for the reproduction of capital as its supply of such labour is depleted. The impact on and response to the epidemic by the state is explored as well as its reflection of marked gender and class inequalities. Conversely the impetus to certain fractions of capital which benefit from AIDS and the confrontation of the state and pharmaceutical companies by an emergent populist movement demanding the right to treatment, exposes the extent to which transformation rather than simple reproduction is in evidence. [ABSTRACT FROM AUTHOR]

Global financing for the HIV response has reached unprecedented levels in recent years. Over US$10 billion were mobilized in 2007, an effort credited with saving the lives of millions of people living with HIV (PLHIV). A relatively unexamined aspect of the global HIV response is the role of the private sector in financing HIV/AIDS services. As the nature of the response evolves from emergency relief to long-term sustainability, understanding current and potential contributions from the private sector is critical. This paper examines trends in private sector financing, management and resource consumption related to HIV/AIDS in five sub-Saharan African countries, with a particular emphasis on the effects of recently scaled-up donor funding on private sector contributions. We analysed National Health Accounts HIV/AIDS subaccount data for Kenya, Malawi, Rwanda, Tanzania and Zambia between 2002 and 2006. HIV subaccounts provide comparable data on the flow of HIV/AIDS funding from source to use. Findings indicate that private sector contributions decreased in all countries except Tanzania. With regards to managing HIV/AIDS funds, non-governmental organizations are increasingly controlling the largest share of resources relative to other stakeholders, whereas private for-profit entities are managing fewer HIV/AIDS resources since the donor influx. The majority of HIV/AIDS funds were spent in the public sector, although a considerable amount was spent at private facilities, largely fuelled by out-of-pocket (OOP) payments. On the whole, OOP spending by PLHIV decreased over the 4-year period, with the exception of Malawi, demonstrating that PLHIV have increased access to free or subsidized HIV/AIDS services. Our findings suggest that the influx of donor funding has led to decreased private contributions for HIV/AIDS. The reduction in private sector investment and engagement raises concerns about the sustainability of HIV/AIDS programmes over the long term, particularly in light of current global economic crisis and emerging competing priorities. [ABSTRACT FROM AUTHOR]

Copyright of Lien Social et Politiques is the property of Institut National de Recherche Scientifique (INRS) and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)

Using country- and region-level data, I investigate the effect of HIV/AIDS on fertility in Africa during 1985-2000. Results differ depending on the variation used and the estimation method. Between estimates that exploit cross-sectional variation suggest a positive significant effect of HIV/AIDS on fertility, whereas within estimates that are identified of off time-series variation show both positive and negative results depending on the HIV/AIDS variable used. These within estimates are insignificant in most of the specifications. [ABSTRACT FROM AUTHOR]

As socio-medical phenomena, epidemics are revealing of the cultures in which they are experienced. The HIV/AIDS epidemic in Africa exposes antecedent tensions between state and society, and, on a broader canvas, between the global north and south. As a contribution to the emerging literature on the social ramifications of HIV/AIDS, this article examines the saga of the Nigerian physician and immunologist, Dr Jeremiah Abalaka, who like other innovators in sub-Saharan Africa claims to have developed a curative HIV vaccine. Whilst articulating the social conditions that enabled Abalaka to thrive, the article explores the marked differences in the reaction to his ‘discovery’ among state representatives, the scientific establishment, the general public, people living with HIV, and the media. Finally, the article valorizes the emergence of new actors in the African health sector, and the diversity of strategies used by ordinary people to achieve and maintain wellness. [ABSTRACT FROM PUBLISHER]

The article explores the relationship between the HIV/AIDS pandemic and poverty. Topics include the high incidence of widow-headed households in Africa, the inability to acquire land and property rights and how the illness exacerbates existing problems such as poverty and gender inequality. Mathematics is used to determine the land disbursement inequality issue and figures that show landholding information is presented. Land inheritance patterns and socioeconomic factors in Zambia are explored and policy recommendations are provided.

Background: The Human Immunodeficiency Virus (HIV) epidemic is more pronounced in sub- Saharan Africa. The ever-increasing prevalence of HIV infection and the continued improvement in clinical management has increased the likelihood of these patients being managed by healthcare workers. The aim of the review was to assess current literature on the risks of transmission of HIV infection and protection of the healthcare worker. Methods: A literature review was performed using MEDLINE articles addressing 'human immunodeficiency virus', 'HIV', 'Acquired immunodeficiency syndrome', 'AIDS', 'HIV and Surgery'. We also manually searched relevant surgical journals and completed the bibliographic compilation by collecting cross references from published papers. Results: Transmission is by contamination with body fluids for example needle-stick injury and blood splashes. The risk of HIV transmission from patient to healthcare worker always exists. The risk oftransmission is very small and depends on the type of discipline and type of procedure. Hollow needles are more dangerous than suture needles. Sero-conversion is, however, very minimal. Universal precautions are emphasised. In case of needle-stick injury or splash it is important that affected healthcare workers take post-exposure prophylaxis. Conclusion: Occupational HIV transmission is lower than that for other infections. However, protection of all health care personnel should be the prime objective. Universal infection control guidelines must be accepted and strictly enforced. A prompt response to blood contact is crucial and post-exposure prophylaxis is essential. [ABSTRACT FROM AUTHOR]

Abstract: This paper describes an initiative to develop a model for understanding the multi-faceted nature and effects of vulnerability. The model is designed to enable analysis and assessment of interventions that address vulnerability, a concept that is widely used across disciplines and in development planning in Africa, particularly in southern Africa. The model is being developed to accommodate analyses of ‘multiple stressors’ and to identify the intersection and interaction of stressors in different contexts. Using three case studies related to vulnerability reduction and HIV/AIDS, we show how multiple processes interact and can influence the outcomes of vulnerability interventions in ways that may not be readily apparent when focusing on one stressor alone. [Copyright &y& Elsevier]

Recently, Africa has become the focus of much media and celebrity attention. In particular, AIDS in Africa has received significant attention. (Product)RED, a business initiative/ philanthropic venture, is one of the most visible campaigns in the effort to raise money for AIDS work on the continent. This paper is guided by a simple theoretical endeavor: I examine how (Product)RED constructs a moral/common sense imperative, using long-held cultural tropes and schemas of Africa to do so. Because western ideas of Africa are so entrenched, (Product)RED can focus our attention on its products and create an impetus to buy them, rather than specifics about AIDS or Africa. Performing a content analysis of the (Product)RED website and its MySpace comments, I analyze how it constructs the problem and solution, and how the (Product)RED message is interpreted by some consumers. [ABSTRACT FROM AUTHOR]

The communicative effectiveness of language use is examined in this paper. This is done with particular reference to the texts of public awareness/sensitization campaigns on HIV/AIDS in Nigeria. Hence texts primarily meant to create awareness and sensitize the general public on the dangers of the HIV/AIDS pandemic are tested in a survey using questionnaires to determine if perceived messages of the texts are understood, as intended. Using the statistics of mean as the common indicator of central tendency, findings show that majority of the respondents do not feel influenced by the awareness and sensitization campaign texts on HIV/AIDS. [editor note: tables provided by the author related to this study were excluded, hence, contact the author for expensive findings regarding the tables: the full written content is present]. [ABSTRACT FROM AUTHOR]

The article presents abstracts of several researches including "Books in Heaven: Dreams, Texts and Conspicuous Circulation," by Isabel Hofmeyr, "Culture as Cure: Civil Society and Moral Debates in KwaZulu-Natal After Apartheid," by Preben Kaarsholm, and "Islam in Northern Mali and the War on Terror," by David Gutelius.

The assumption that 'There Is No Alternative' (TINA) to capitalism as practiced in the United States of America and Western Europe has been the bane of aids effectiveness in assisting to solve the underdevelopment problem in Africa. This paper attempts to show that except there is a fundamental reorientation in the conceptualization of capitalism-free market and democracy-the underdevelopment problem would only be further complicated with aids. [ABSTRACT FROM AUTHOR]

Diarrhoea was estimated to account for 18% of the estimated 10.6 million deaths of children aged less than five years annually in 2003. Two--Africa and South-East Asia--of the six regions of the World Health Organization accounted for approximately 40% and 31% of these deaths respectively, or almost three-quarters of the global annual deaths of children aged less than five years attributable to diarrhoea. Much of the effort to roll out low-osmolarity oral rehydration solution (ORS) and supplementation of zinc for the management of diarrhoea accordingly is being devoted to sub-Saharan Africa and to South and South-East Asia. A number of significant differences exist in diarrhoea-treatment behaviours and challenges of the public-health systems between Africa and Asia. The differences in rates of ORS use are the most common indicator of treatment of diarrhoea and vary dramatically by and within region and may significantly influence the roll-out strategy for zinc and low-osmolarity ORS. The prevalence of HIV/AIDS and the endemi-city of malaria also differ greatly between regions; both the diseases consume the attention and financial commitment of public-health programmes in regions where rates are high. This paper examined how these differences could affect the context for the introduction of zinc and low-osmolarity ORS at various levels, including the process of policy dialogue with local decision-makers, questions to be addressed in formative research, implementation approaches, and strategies for behaviour-change communication and training of health workers. [ABSTRACT FROM AUTHOR]

The emergence of alternative medicines for AIDS in Asia and Africa was discussed at a satellite symposium and the parallel session on alternative and traditional treatments of the AIDSImpact meeting, held in Marseille, in July 2007. These medicines are heterogeneous, both in their presentation and in their geographic and cultural origin. The sessions focused on the role of these medications in selected resource poor settings in Africa and Asia now that access to anti-retroviral therapy is increasing. The aims of the sessions were to (1) identify the actors involved in the diffusion of these alternative medicines for HIV/AIDS, (2) explore uses and forms, and the way these medicines are given legitimacy, (3) reflect on underlying processes of globalisation and cultural differentiation, and (4) define priority questions for future research in this area. This article presents the insights generated at the meeting, illustrated with some findings from the case studies (Uganda, Senegal, Benin, Burkina Faso, China and Indonesia) that were presented. These case studies reveal the wide range of actors who are involved in the marketing and supply of alternative medicines. Regulatory mechanisms are weak. The efficacy claims of alternative medicines often reinforce a biomedical paradigm for HIV/AIDS, and fit with a healthy living ideology promoted by AIDS care programs and support groups. The AIDSImpact session concluded that more interdisciplinary research is needed on the experience of people living with HIV/AIDS with these alternative medicines, and on the ways in which these products interact (or not) with anti-retroviral therapy at pharmacological as well as psychosocial levels. [ABSTRACT FROM AUTHOR]

The author reflects on the profile of occupational hygiene in the African continent. Particular focus is given to public health problems in Africa which comprised of child mortality, malnutrition, water quality and AIDS. These health factors are the principal causes of the short life expectancy conditions of the African population.

The article argues that education and learning, if selectively and sensitively provided, would help African farm families preserve their assets in the face of HIV/AIDS. According to the author, HIV and AIDS degrade the assets of African farm families by eroding their time, human capital, physical capital and financial resources. Education, both formal and non-formal, is an external intervention that would help farm families offset the effects of HIV/AIDS by enabling family members to enhance their knowledge, augment their skills and take advantage of new information about production, consumption and welfare-enhancing opportunities.

Introduction: Trans people are disproportionately impacted by HIV yet have not been adequately prioritized in national HIV responses or policy documents. This review aims to understand the extent of meaningful inclusion of trans people in national strategic plans (NSPs) for HIV/AIDS as an essential step in ensuring that HIV policy aligns with epidemiologic data, and trans‐specific programming is funded, implemented and sustained. Methods: HIV NSPs from 60 countries, across five global regions, were assessed for the level of inclusion of trans populations between January and March 2021. The most recently available NSP for each country, published after 2011, was obtained through publicly accessible online sources or through researcher networks. Data were manually extracted from NSPs using a framework of indicators focusing on trans inclusion in these five major sections of NSPs: (1) narratives; (2) epidemiological data; (3) monitoring and evaluation (M&E) indicators and targets; (4) activities; and (5) budgets. Results and discussion: Within all reviewed NSPs, 65.0% (39/60) mentioned trans people in at least one of the five key sections but only 8.3% (5/60) included trans people in all five key sections. Trans people were more commonly mentioned in the background/narratives of NSPs (61.7%, 37/60) but less commonly included NSP activities (38.3%, 23/60), in M&E indicators and targets (23.7%, 14/60), in epidemiological data (20.0% 12/60), and in NSP budgets (13.3%, 8/60). Countries in the Asia and Pacific region most frequently included trans people in all five key sections (38%, 5/13), while no countries in Eastern and Southern Africa included trans people in all NSP sections. Conclusions: This analysis finds substantial gaps in the inclusion of trans populations in NSPs globally. Results highlight the pressing need for states, technical partners, and international funders to engage with trans communities to improve trans‐inclusion in all key sections of NSPs. Trans inclusion in NSPs is an essential step towards reaching the populations most at risk of HIV and ultimately achieving country‐level epidemic control. [ABSTRACT FROM AUTHOR]

Background: A multi-sectoral response is advocated by international organisations as a good strategy to address the multiple drivers and impact of human immunodeficiency virus/acquired immune deficiency syndrome (HIV/AIDS), and was historically mandated as a condition of funding. In March 2017, the South African National AIDS Council (SANAC) launched the latest 5 year National Strategic Plan (NSP) to address HIV, sexually transmitted infections and tuberculosis. As with previous iterations, the NSP calls for multi-sectoral action (MSA) and mandates AIDS councils (ACs) at different levels to coordinate its implementation. Efforts have been made to advocate for the adoption of MSA in South Africa, yet evaluation of these efforts is currently limited. Objective: This paper assesses the implementation of a multi-sectoral response to HIV in South Africa, through a case study of the Mpumalanga Province. Methods: We identified and reviewed key policy documents, conducted 12 interviews and held six focus group discussions. We also drew on our involvement, through participant observation, in the development of NSPs and in AC meetings. Results: SANAC is struggling to provide much-needed support to provincial, district and local ACs. Therefore, most ACs are generally weak and failing to implement MSA. Membership is voluntary, there is a lack of sustained commitment and they do not include representatives from all sectors. There is little capacity to undertake the activities necessary for coordinating the implementation of MSA, and unclear roles and responsibilities within ACs result in divisions and tension between sectors. There is inadequate senior political leadership and funding to facilitate effective implementation of MSA. Conclusion: We identified three interventions that we argue are required to support the effective implementation of MSA: strengthening and stabilising the SANAC structure; building capacity of ACs; and creating an enabling environment for effective implementation of MSA through political leadership, support and resourcing of the HIV response. [ABSTRACT FROM PUBLISHER]

The author reflects on the research conducted by researcher Adebajo and her colleagues regarding the same-sex relationships in Africa. The author states the research shows the possibility of opening up debate and conduct empirical research in less receptive communities. The author notes the high prevalence of internalized homophobia among men who have sex with men. The author mentions the importance of conducting a social and anthropological research to identify risk factors and determinants of same-sex relationships.

This article comments on the paper by John Caldwell, Pat Caldwell and Pat Quiggin, which posited the existence of a distinct and internally coherent African system embracing sexuality, marriage and much else. These authors argued that this system characterized by extensive female sexual freedom, stands in sharp contrast to the corresponding Western system, designated the Eurasian system in a term borrowed from Jack Goody. If this thesis is correct, they assert, it follows that the African system will be vulnerable to attack by all coital-related disorders and thus to AIDS. Caldwell and his coauthors present their argument in two sections. In the first, they attempt to show the existence of a distinct African sexual system by discussing its principal characteristics, namely the absence of moral and institutional limitations on sexual practices, especially concerning women. In the second, the authors discuss the character of this sexual system as an important factor in the spread of AIDS. They describe sexual practices quantitatively and qualitatively by evaluating the frequency of encounters with different partners and by identifying the sexual networks in which individuals are involved.

Objectives: We extend the method of Significant Zero Crossings of Derivatives (SiZer) to address within-subject correlations of repeatedly collected longitudinal biomarker data and the computational aspects of the methodology when analyzing massive biomarker databases. SiZer is a powerful visualization tool for exploring structures in curves by mapping areas where the first derivative is increasing, decreasing or does not change (plateau) thus exploring changes and normalization of biomarkers in the presence of therapy. Methods: We propose a penalized spline SiZer (PS-SiZer) which can be expressed as a linear mixed model of the longitudinal biomarker process to account for irregularly collected data and within-subject correlations. Through simulations we show how sensitive PS-SiZer is in detecting existing features in longitudinal data versus existing versions of SiZer. In a real-world data analysis PS-SiZer maps are used to map areas where the first derivative of weight change after antiretroviral therapy (ART) start is significantly increasing, decreasing or does not change, thus exploring the durability of weight increase after the start of therapy. We use weight data repeatedly collected from persons living with HIV initiating ART in five regions in the International Epidemiologic Databases to Evaluate AIDS (IeDEA) worldwide collaboration and compare the durability of weight gain between ART regimens containing and not containing the drug stavudine (d4T), which has been associated with shorter durability of weight gain. Results: Through simulations we show that the PS-SiZer is more accurate in detecting relevant features in longitudinal data than existing SiZer variants such as the local linear smoother (LL) SiZer and the SiZer with smoothing splines (SS-SiZer). In the illustration we include data from 185,010 persons living with HIV who started ART with a d4T (53.1%) versus non-d4T (46.9%) containing regimen. The largest difference in durability of weight gain identified by the SiZer maps was observed in Southern Africa where weight gain in patients treated with d4T-containing regimens lasted 59.9 weeks compared to 133.8 weeks for those with non-d4T-containing regimens. In the other regions, persons receiving d4T-containing regimens experienced weight gains lasting 38–62 weeks versus 55–93 weeks in those receiving non-d4T-based regimens. Discussion: PS-SiZer, a SiZer variant, can handle irregularly collected longitudinal data and within-subject correlations and is sensitive in detecting even subtle features in biomarker curves. [ABSTRACT FROM AUTHOR]