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Bearing is one of the critical components in rotating equipment. Therefore, accurate estimation of the remaining useful life (RUL) of bearings plays a vital role in reducing the costly unplanned maintenance and increasing the reliability of machines. This paper proposes a method for bearing prognostics that uses iteratively updated degradation regression models to capture the degradation trend in bearing’s health indicator (HI), and the models are utilized to predict the degradation trajectory of HI and to estimate the RUL of bearings. The importance of determining the time to start prediction by elbow point is explained, which is often overlooked in prognostics. To improve the prognostic performance, an adaptive approach for elbow point detection is designed based on the gradient change of HIs, and a new smooth approach is applied to reduce spurious fluctuations in degradation trajectory. The effectiveness of the proposed method is validated on two publicly available data sets, i.e., IMS and FEMTO bearing prognostics data set, and its prognostic performance is compared with that of three state-of-the-art methods. The obtained results demonstrate that the proposed method can effectively detect elbow point and determine the time to start prediction, and can calibrate the degradation regression model dynamically according to the evolving degradation trend in the HI, which validates its superior prognostic performance.

In recent years, with the rapid development of techniques in bioinformatics and life science, a considerable quantity of biomedical data has been accumulated, based on which researchers have developed various computational approaches to discover potential associations between human microbes, drugs and diseases. This paper provides a comprehensive overview of recent advances in prediction of potential correlations between microbes, drugs and diseases from biological data to computational models. Firstly, we introduced the widely used datasets relevant to the identification of potential relationships between microbes, drugs and diseases in detail. And then, we divided a series of a lot of representative computing models into five major categories including network, matrix factorization, matrix completion, regularization and artificial neural network for in-depth discussion and comparison. Finally, we analysed possible challenges and opportunities in this research area, and at the same time we outlined some suggestions for further improvement of predictive performances as well.

Background The quantity of metastases lesions is an important reference when it comes to making a more informed treatment decision for patients with colorectal cancer liver metastases. However, the molecular alterations in patients with different numbers of lesions have not been systematically studied. Methods We investigated somatic alterations and microsatellite instability (MSI) of liver metastases from patients with single, multiple or diffuse metastasis lesions. A new algorithm “Pathway Damage Score” was developed to comprehensively assess the functional impact of somatic alterations at the pathway level. Pathogenic pathways of different metastasis were identified and their prognosis effects were evaluated. Furthermore, the subnetworks and affected phenotypes of the altered genes in each pathogenic pathway were analyzed. Results Somatic alterations and altered genes occurred sporadically as well as in MSI state in different metastasis types, although MSS patients had more metastatic lesions than that of the MSI patients. Every metastasis group has their own pathogenic pathways and damaged “Cargo recognition for clathrin‐mediated endocytosis” is significantly associated with poor prognosis (P

Large numbers of MS/MS peptide spectra generated in proteomics experiments require efficient, sensitive and specific algorithms for peptide identification. In the Open Mass Spectrometry Search Algorithm (OMSSA), specificity is calculated by a classic probability score using an explicit model for matching experimental spectra to sequences. At default thresholds, OMSSA matches more spectra from a standard protein cocktail than a comparable algorithm. OMSSA is designed to be faster than published algorithms in searching large MS/MS datasets. Keywords: protein identification • algorithm • bioinformatics • mass spectrometry • proteomics • significance testing