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Effects of somatic alterations at pathway level are more mechanism‐explanatory and clinically applicable to quantity of liver metastases of colorectal cancer
- Source :
- Cancer Medicine, Vol 8, Iss 10, Pp 4732-4742 (2019), Cancer Medicine
- Publication Year :
- 2019
- Publisher :
- Wiley, 2019.
-
Abstract
- Background The quantity of metastases lesions is an important reference when it comes to making a more informed treatment decision for patients with colorectal cancer liver metastases. However, the molecular alterations in patients with different numbers of lesions have not been systematically studied. Methods We investigated somatic alterations and microsatellite instability (MSI) of liver metastases from patients with single, multiple or diffuse metastasis lesions. A new algorithm “Pathway Damage Score” was developed to comprehensively assess the functional impact of somatic alterations at the pathway level. Pathogenic pathways of different metastasis were identified and their prognosis effects were evaluated. Furthermore, the subnetworks and affected phenotypes of the altered genes in each pathogenic pathway were analyzed. Results Somatic alterations and altered genes occurred sporadically as well as in MSI state in different metastasis types, although MSS patients had more metastatic lesions than that of the MSI patients. Every metastasis group has their own pathogenic pathways and damaged “Cargo recognition for clathrin‐mediated endocytosis” is significantly associated with poor prognosis (P
- Subjects :
- 0301 basic medicine
Cancer Research
Somatic cell
Colorectal cancer
Clinical Decision-Making
survival
lcsh:RC254-282
Metastasis
03 medical and health sciences
0302 clinical medicine
Exome Sequencing
Humans
Medicine
Gene Regulatory Networks
Radiology, Nuclear Medicine and imaging
In patient
Gene
Neoplasm Staging
Original Research
Cancer Biology
algorithm
business.industry
Mechanism (biology)
Liver Neoplasms
liver metastases lesions
Microsatellite instability
lcsh:Neoplasms. Tumors. Oncology. Including cancer and carcinogens
medicine.disease
Survival Analysis
somatic alterations
Phenotype
030104 developmental biology
cancer pathways
Oncology
030220 oncology & carcinogenesis
Disease Progression
Cancer research
Microsatellite Instability
Colorectal Neoplasms
business
Algorithms
Subjects
Details
- ISSN :
- 20457634
- Volume :
- 8
- Database :
- OpenAIRE
- Journal :
- Cancer Medicine
- Accession number :
- edsair.doi.dedup.....8fc971f1144d23c322be1dceac50b97f