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Research describes an highly diastereoselective intermolecular coupling of imines possessing a beta-hydroxy group with a Lewis acid and a single-electron reduction system. The reaction represents imine dimerization with samarium involving chelation control by aluminum for the N-benzylideneamino alcohol radical.

Research has been conducted on the optically active imino alcohol-type aldimine. The Barbier-type allylation of this aldimine which proceeded with high regio- and stereoselectivity is described.

Platinum(II) chloride as a Lewis acid catalyst was employed to perform concise and efficient syntheses of indole carbamates, 1,2-dihydroisoquinoline carbamates, macrocyclic indole carbamates, indole ureas and indole phosphoranes. The reaction rate could be enhanced by performing the reaction under microwave irradiation.

The development of a concise synthesis of the CDE ring system of the tetrahydroisoquinoline antitumor alkaloids such as saframycins, renieramycins, and ecteinascidins is reported. The key steps in the reaction include Au(I)-catalyzed intramolecular hydroamidation and NBS-mediated oxidative Friedel-Crafts cyclization.

The development of a new atom-economical In[(OTf).sub.3]-catalyzed synthesis of ring-condensed heteroaromatic compounds via a domino intramolecular nucleophilic attack/intermolecular cycloaddition/dehydration reaction is reported. The synthesis used readily available ortho-alkynylanilines and ortho-alkynylbenzaldehydes as starting materials.

A study develops efficient catalytic methods for the stereoselective and diversity synthesis of various (E)-, (Z)-, and disubstituted 3-alkylideneoxindoles and 3-alkylidenebenzofuran-2-ones via palladium-catalyzed domino reactions. The method provides a versatile tool for further synthesis of natural products and random screening in the search for drug candidates.