Search

Your search keyword '"Turner, C. E."' showing total 309 results
Start Over Author "Turner, C. E." Search Limiters Available in Library Collection
309 results on '"Turner, C. E."'

1. A re-interpretation of the late Bronze Age metalwork hoards of Essex and Kent

Author

Turner, C. E. Louise

Subjects
930.1, CC Archaeology
Abstract

Recent works have offered an alternative to traditional archaeological classification, particularly in the field of ceramic studies. These use theories of human categorisation processes derived from other areas of research, in particular psychology and linguistics. The purpose of this thesis was - through reference to the advances made in studies of this kind - to re-interpret a body of metalwork evidence, in particular the 'founder's hoards' of the 'Carp's Tongue' Complex in Essex and Kent. These hoards include a wide range of artefact categories, often surviving in fragmentary condition, and have traditionally been interpreted as an inevitable by-product of the metalworking process. By examining the nature of the contents and the structure of these hoards, and by making a detailed appraisal of the manner in which each of the individual artefact categories included was treated prior to its inclusion in the hoard, it was possible to establish that there was indeed a strong association with the metalworking process. It also became apparent that regularised methods of destruction were employed upon the artefact categories included in these hoards, and that specific selection processes operated during the accumulation of the hoard contents, with certain artefact categories being favoured for inclusion. It therefore seemed likely that, instead of being a direct by-product of the metalworking process, these hoards were instead collections of metalwork which deliberately referenced the metalworking process, as well as other routine activities, such as the agricultural cycle. By considering these findings within a wider context, it was possible to see these hoards as functioning as material props in ceremonies which created metaphorical associations between activities often perceived by archaeologists as being secular in character with more metaphysical aspects of existence, such as the transformation of the body after death.

Published
1998

9. Discussion

Author

Irwin, G. R., Sullivan, A. M., Hull, D., Knott, J. F., Boyd, G. M., Nutting, J., Bradshaw, F. J., McClintock, F. A., Williams, J. G., Turner, C. E., Oates, G., Broomfield, G. H., Cottrell, A. H., Bilby, B. A., Swinden, K. H., Wells, A. A., Nichols, R. W., and Stone, D. E. W.

Published
1965

22. De novo variants in CDK13 associated with syndromic ID/DD : Molecular and clinical delineation of 15 individuals and a further review

Author

van den Akker, W. M.R., Brummelman, I., Martis, L. M., Timmermans, R. N., Pfundt, R., Kleefstra, T., Willemsen, M. H., Gerkes, E. H., Herkert, J. C., van Essen, A. J., Rump, P., Vansenne, F., Terhal, P. A., van Haelst, M. M., Cristian, I., Turner, C. E., Cho, M. T., Begtrup, A., Willaert, R., Fassi, E., van Gassen, K. L.I., Stegmann, A. P.A., de Vries, B. B.A., Schuurs-Hoeijmakers, J. H.M., van den Akker, W. M.R., Brummelman, I., Martis, L. M., Timmermans, R. N., Pfundt, R., Kleefstra, T., Willemsen, M. H., Gerkes, E. H., Herkert, J. C., van Essen, A. J., Rump, P., Vansenne, F., Terhal, P. A., van Haelst, M. M., Cristian, I., Turner, C. E., Cho, M. T., Begtrup, A., Willaert, R., Fassi, E., van Gassen, K. L.I., Stegmann, A. P.A., de Vries, B. B.A., and Schuurs-Hoeijmakers, J. H.M.

Published
2018

23. De novo variants in CDK13 associated with syndromic ID/DD: Molecular and clinical delineation of 15 individuals and a further review

Author

PMC Medisch specialisten, Genetica, Genetica Klinische Genetica, Child Health, Genetica Sectie Genoomdiagnostiek, Projectafdeling ALS, Brain, van den Akker, W. M.R., Brummelman, I., Martis, L. M., Timmermans, R. N., Pfundt, R., Kleefstra, T., Willemsen, M. H., Gerkes, E. H., Herkert, J. C., van Essen, A. J., Rump, P., Vansenne, F., Terhal, P. A., van Haelst, M. M., Cristian, I., Turner, C. E., Cho, M. T., Begtrup, A., Willaert, R., Fassi, E., van Gassen, K. L.I., Stegmann, A. P.A., de Vries, B. B.A., Schuurs-Hoeijmakers, J. H.M., PMC Medisch specialisten, Genetica, Genetica Klinische Genetica, Child Health, Genetica Sectie Genoomdiagnostiek, Projectafdeling ALS, Brain, van den Akker, W. M.R., Brummelman, I., Martis, L. M., Timmermans, R. N., Pfundt, R., Kleefstra, T., Willemsen, M. H., Gerkes, E. H., Herkert, J. C., van Essen, A. J., Rump, P., Vansenne, F., Terhal, P. A., van Haelst, M. M., Cristian, I., Turner, C. E., Cho, M. T., Begtrup, A., Willaert, R., Fassi, E., van Gassen, K. L.I., Stegmann, A. P.A., de Vries, B. B.A., and Schuurs-Hoeijmakers, J. H.M.

Published
2018

30. Backtalk

Author

Adair, F. L., Sobel, Harold W., Roberts, Harold B., Turner, C. E., Schwartz, Albert V., Hays, Michael L., Moellenberg, Wayne, Jenkins, Jerry A., and Schafer, Walter E.

Published
1969

35. De novo variants in <italic>CDK13</italic> associated with syndromic ID/DD: Molecular and clinical delineation of 15 individuals and a further review.

Author

van den Akker, W. M. R., Brummelman, I., Martis, L. M., Timmermans, R. N., Pfundt, R., Kleefstra, T., Willemsen, M. H., de Vries, B. B. A., Schuurs‐Hoeijmakers, J. H. M., Gerkes, E. H., Herkert, J. C., van Essen, A. J., Rump, P., Vansenne, F., Terhal, P. A., van Gassen, K. L. I., van Haelst, M. M., Cristian, I., Turner, C. E., and Cho, M. T.

Subjects
CYCLIN-dependent kinases, CONGENITAL heart disease, DEVELOPMENTAL delay, FACIAL abnormalities, EXOMES
Abstract

De novo variants in the gene encoding cyclin‐dependent kinase 13 (CDK13) have been associated with congenital heart defects and intellectual disability (ID). Here, we present the clinical assessment of 15 individuals and report novel de novo missense variants within the kinase domain of CDK13. Furthermore, we describe 2 nonsense variants and a recurrent frame‐shift variant. We demonstrate the synthesis of 2 aberrant CDK13 transcripts in lymphoblastoid cells from an individual with a splice‐site variant. Clinical characteristics of the individuals include mild to severe ID, developmental delay, behavioral problems, (neonatal) hypotonia and a variety of facial dysmorphism. Congenital heart defects were present in 2 individuals of the current cohort, but in at least 42% of all known individuals. An overview of all published cases is provided and does not demonstrate an obvious genotype‐phenotype correlation, although 2 individuals harboring a stop codons at the end of the kinase domain might have a milder phenotype. Overall, there seems not to be a clinically recognizable facial appearance. The variability in the phenotypes impedes an à vue diagnosis of this syndrome and therefore genome‐wide or gene‐panel driven genetic testing is needed. Based on this overview, we provide suggestions for clinical work‐up and management of this recently described ID syndrome. [ABSTRACT FROM AUTHOR]

Published
2018
Full Text
View/download PDF

37. Angiotensin II stimulation of rapid paxillin tyrosine phosphorylation correlates with the formation of focal adhesions in rat aortic smooth muscle cells

Author

Turner, C. E., Pietras, K. M., Taylor, D. S., and Christopher Molloy

Subjects
Becaplermin, macromolecular substances, environment and public health, Muscle, Smooth, Vascular, Cell Adhesion, Animals, Phosphorylation, Phosphotyrosine, Aorta, Cells, Cultured, Platelet-Derived Growth Factor, Angiotensin II, Endothelins, Thrombin, Proto-Oncogene Proteins c-sis, Cell Biology, Protein-Tyrosine Kinases, Phosphoproteins, Receptor, Insulin, Recombinant Proteins, Rats, Cytoskeletal Proteins, Kinetics, enzymes and coenzymes (carbohydrates), Focal Adhesion Kinase 1, Focal Adhesion Protein-Tyrosine Kinases, Tetradecanoylphorbol Acetate, Tyrosine, Stress, Mechanical, Paxillin, Cell Adhesion Molecules
Abstract

Angiotensin II is a potent vasoconstrictor that has been also implicated in vascular hyperproliferative diseases, including atherosclerosis and restenosis following angioplasty. Treatment of cultured, serum-starved rat aortic smooth muscle cells with angiotensin II causes rapid protein tyrosine phosphorylation that precedes cell mitogenesis. We have identified two of the phosphoproteins as paxillin (75 kilodaltons) and the tyrosine kinase pp125Fak, both components of actin-associated focal adhesion sites. Angiotensin II stimulated a 5-fold increase in the tyrosine phosphorylation of paxillin and a smaller (1.5-fold) increase in pp125Fak tyrosine phosphorylation. Paxillin tyrosine phosphorylation was evident within 1 minute, and was maximal after 10 minutes. Similar elevated protein tyrosine phosphorylation levels of paxillin were obtained with exposure of the rat aortic smooth muscle cells to peptides endothelin-1 and alpha-thrombin that function, as angiotensin II, through binding to members of the seven transmembrane domain G protein coupled receptors. Angiotensin II treatment also stimulated the production of a well-ordered actin-containing stress fiber network and prominent paxillin-containing focal adhesions. The focal adhesions stained intensely with anti-phosphotyrosine antibody suggesting the tyrosine phosphorylation of paxillin and cytoskeletal reorganization were tightly coupled. Angiotensin II receptor occupancy has been shown previously to lead to protein kinase C activation. However, compared to angiotensin II stimulation, a smaller, delayed increase in paxillin tyrosine phosphorylation was observed following direct protein kinase C activation by the phorbol ester phorbol 12-myristate-13-acetate. Paxillin tyrosine phosphorylation was selective for certain agonists since no increase in tyrosine phosphorylation of this protein was observed following exposure to the potent mitogen PDGF. Thus, actin-based cytoskeletal changes involving sites of cell adhesion to the extracellular matrix may play an important role in normal and pathophysiologic smooth muscle cell growth regulation in response to certain angiotensin II-type vasoactive agonists.

Published
1995

45. Thrombin receptor activation elicits rapid protein tyrosine phosphorylation and stimulation of the raf-1/MAP kinase pathway preceding delayed mitogenesis in cultured rat aortic smooth muscle cells: evidence for an obligate autocrine mechanism promoting cell proliferation induced by G-protein-coupled receptor agonist.

Author

Molloy, C J, primary, Pawlowski, J E, additional, Taylor, D S, additional, Turner, C E, additional, Weber, H, additional, and Peluso, M, additional

Published
1996
Full Text
View/download PDF

Catalog

Books, media, physical & digital resources
See catalog results