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Introduction Intentional pesticide poisoning is a major clinical and public health problem in agricultural communities in low and middle income countries like Nepal. Bans of highly hazardous pesticides (HHP) reduce the number of suicides. We aimed to identify these pesticides by reviewing data from major hospitals across the country and from forensic toxicology laboratories. Methods We retrospectively reviewed medical records of 10 hospitals for pesticide poisoned patients and two forensic laboratories of Nepal from April 2017 to February 2020. The poison was identified from the history, referral note, and clinical toxidrome in the hospitals and from gas chromatography analysis in the laboratories. Data on demographics, poison, and patient outcome were recorded on a data collection sheet. Simple descriptive analysis was performed. Results Among hospital cases (n = 4148), the commonest form of poisoning was self-poisoning (95.8%) while occupation poisoning was rare (0.03%). Case fatality was 5.3% (n = 62). Aluminum phosphide (n = 38/62, 61.3%) was the most commonly identified lethal pesticide for deaths. Forensic toxicology laboratories reported 2535 deaths positive for pesticides, with the compounds most commonly identified being organophosphorus (OP) insecticides (n = 1463/2535; 57.7%), phosphine gas (n = 653/2535; 25.7%; both aluminum [11.8%] and zinc [0.4%] phosphide) and organochlorine insecticides (n = 241/2535; 9.5%). The OP insecticide most commonly identified was dichlorvos (n = 273/450, 60.6%). Conclusion The data held in the routine hospital medical records were incomplete but suggested that case fatality in hospitals was relatively low. The pesticides identified as causing most deaths were dichlorvos and aluminum phosphide. Since this study was completed, dichlorvos has been banned and the most toxic formulation of aluminum phosphide removed from sale. Improving the medical record system and working with forensic toxicology laboratories will allow problematic HHPs to be identified and the effects of the bans in reducing deaths monitored.

Background: With the increasing number of Chronic Kidney Disease (CKD), emergency visit of these patients is also increasing. This study tried to find some of the reasons for which patients with CKD visit the emergency room and the reasons for their mortality. Method: A cross-sectional study was done in the emergency room of Tribhuvan University Teaching Hospital, Kathmandu, Nepal. We conducted this study from 1 May 2018 to 31 October 2018 among the adult CKD patients under regular hemodialysis. We used a convenience sampling method. Three hundred patients were included. We studied the following variables: patient’s age, sex, risk factors, laboratory parameter during the emergency visit (viz. hemoglobin, pH, serum bicarbonate level, and potassium level), emergency hemodialysis, blood transfusion, and clinical outcome during emergency room stay. Result: We enrolled 300 patients in the study. The mean age was 45.04 years in the mortality group and 45.69 years in the survival group 152 (50.7%) of patients had hypertension. Mean hemoglobin was 6.52gm% (SD = 1.93). Mean hemoglobin in survivor and the non-survivor group was 6.59 gm% and 5.58 gm% respectively. Serum creatinine was 1220.87 mmol/L and 1064.01 mmol/L in mortality and survivor group respectively. Likewise, serum potassium was 6.13 mEq/l and 5.74 mEq/l among mortality and survivor groups respectively. Binary logistic regression showed significant association (p

Emergency workers carry a huge responsibility in Covid 19 pandemic. Emergency staff have to provide prehospital care, early triage and management of patients with suspected or confirmed infection. More importantly, emergency care givers have to do everything to prevent emergency room from spread of the infection, to other patients. Access blocks following increasing flow of patients with suspicion of infection, causes overwhelming patients leading to delayed care and resource shortage to patients with chronic and acute diseases. This surge has put emergency workers at risk: risk from a potential contamination and risk from the effect of extended shifts work in the hospital. At this stage, the major challenges while performing emergency service has been managing triage, human resources, limited stock of personal protective equipment (PPE), proper management of infection prevention and limited laboratories for testing. Due to lack of those requirements, certain guidelines and running the service without such guidelines making the emergency service in difficult situation during such crisis period.

Primary health care provides the framework for delivering the socially-informed, comprehensive and patient-centred care underlying robust health-care systems and is, therefore, central to achieving universal health coverage. Family physicians are best placed to embody primary health care's dual focus on community and population health because they are often employed in rural or district hospitals with limited human resources, particularly a lack of specialists. Here we want to illustrate how additional training for family physicians, the key clinicians in primary care, can play a critical role in reducing disparities in access to surgical, obstetric and anaesthesia care in low- and middle-income countries and in rural or remote settings. Examples are given of how training programmes can be developed in low-resource settings to equip family physicians with life-saving surgical skills and of how family physicians in high-income countries can be trained in the surgical skills essential for working overseas in low-income settings. Policy-makers should promote surgical practice among family physicians by supporting family medicine programmes that include additional surgical skills training and by expanding opportunities and incentives for family physicians to serve in rural areas. Moreover, national surgical plans should include a primary health care strategy for surgical care and, globally, family physicians should be considered in discussions of surgical care. Finally, surgeons, anaesthesiologists, obstetricians and family physicians should be encouraged to collaborate in ensuring that all patients, regardless of place of residence, receive safe and timely surgical care.Les soins de santé primaires établissent le cadre requis pour des soins complets adaptés aux patients, gages d'un système de santé solide. Ils jouent donc un rôle central dans la mise en place d'une couverture maladie universelle. Dans ce contexte, les médecins de famille sont les mieux placés pour incarner une double perspective, la santé communautaire et la santé des populations, car ils travaillent souvent dans des hôpitaux ruraux ou de district qui disposent de ressources humaines limitées, surtout en termes de spécialistes. Le présent document montre dans quelle mesure une formation complémentaire dédiée aux médecins de famille, acteurs clés des soins de santé primaires, peut avoir un impact décisif sur la diminution des inégalités d'accès aux interventions chirurgicales, obstétriques et anesthésiques dans les pays à faible et moyen revenu, ainsi que dans les milieux ruraux ou isolés. Il existe de nombreux exemples qui illustrent la façon dont les programmes de formation peuvent être mis en œuvre dans les endroits manquant de ressources afin que les médecins de famille acquièrent des compétences chirurgicales vitales, et qui indiquent comment les médecins de famille des pays à haut revenu peuvent apprendre des techniques de chirurgie essentielles pour travailler outre-mer ou dans des régions plus défavorisées. Les législateurs devraient promouvoir la pratique chirurgicale chez les médecins de famille en soutenant les programmes qui incluent une formation complémentaire aux techniques de chirurgie, et en multipliant les opportunités et sources de motivation pour que les médecins de famille exercent dans les zones rurales. Par ailleurs, les projets nationaux devraient comporter une stratégie de soins de santé primaires pour les actes chirurgicaux et, globalement, les médecins de famille devraient être pris en compte dans les discussions consacrées aux interventions chirurgicales. Enfin, chirurgiens, anesthésistes, obstétriciens et médecins de famille devraient être encouragés à collaborer pour s'assurer que tous les patients, quel que soit leur lieu de résidence, puissent bénéficier de soins chirurgicaux au moment opportun et en toute sécurité.La atención primaria de salud establece el marco para la prestación de una atención socialmente informada, integral y centrada en el paciente, que es la base de los sistemas sólidos de atención sanitaria y, por lo tanto, es fundamental para lograr la cobertura sanitaria universal. Los médicos de familia son los que mejor pueden asumir el doble enfoque de la atención primaria en la salud de la comunidad y de la población porque trabajan con frecuencia en hospitales rurales o de distrito que tienen recursos humanos limitados, en especial por la falta de especialistas. En este documento, se pretende ilustrar cómo la capacitación adicional de los médicos de familia, quienes son los profesionales clínicos clave en la atención primaria, puede desempeñar una función esencial en la reducción de las desigualdades que existen para acceder a los procedimientos quirúrgicos, obstétricos y de anestesia en los países de ingresos bajos y medios y en los zonas rurales o remotas. También se dan ejemplos de cómo se pueden elaborar programas de capacitación en entornos de bajos recursos para preparar a los médicos de familia con técnicas quirúrgicas que salvan vidas y de cómo se puede capacitar a los médicos de familia de los países de altos ingresos sobre las técnicas quirúrgicas esenciales para que trabajen en el extranjero en entornos de bajos ingresos. Los responsables de formular políticas deben promover la práctica quirúrgica entre los médicos de familia mediante su apoyo a los programas de medicina familiar que incluyan una capacitación adicional sobre técnicas quirúrgicas, así como la ampliación de las oportunidades y de los incentivos para que los médicos de familia presten servicios en las zonas rurales. Además, los planes quirúrgicos nacionales deben incluir una estrategia de atención primaria de salud para la intervención quirúrgica y, a nivel mundial, los médicos de familia se deben tener en cuenta en los debates sobre la intervención quirúrgica. Por último, se debe alentar a los cirujanos, anestesiólogos, obstetras y médicos de familia a que colaboren para garantizar que todos los pacientes, sea cual sea su lugar de residencia, reciban servicios quirúrgicos seguros y oportunos.توفر الرعاية الصحية الأولية الإطار المطلوب لتقديم الرعاية الشاملة، الواعية اجتماعياً، والتي تركز على المريض، والتي تعتمد على أنظمة الرعاية الصحية الفعالة، وبالتالي فهي مركزية لتحقيق التغطية الصحية الشاملة. يعتبر طبيب الأسرة في وضع أفضل لتجسيد التركيز الثنائي للرعاية الصحية الأولية على صحة المجتمع والسكان، وذلك لأنه غالبًا ما يعمل في مستشفيات ريفية أو محلية تعاني من موارد بشرية محدودة، وبخاصة نقص في المتخصصين. نريد هنا أن نوضح كيف يمكن للتدريب الإضافي لطبيب الأسرة، والأطباء السريريين الرئيسيين في الرعاية الأولية، أن يلعبوا دورًا حاسمًا في الحد من التفاوتات في الحصول على الرعاية في العمليات الجراحية، وعمليات التوليد، والتخدير في البلدان ذات الدخل المنخفض والمتوسط، وفي المناطق الريفية أو النائية. يتم تقديم أمثلة على كيفية تطوير برامج التدريب في الأماكن منخفضة الموارد، لتزويد طبيب الأسرة بالمهارات الجراحية المنقذة للحياة، وكيف يمكن تدريب طبيب الأسرة في البلدان ذات الدخل المرتفع على المهارات الجراحية الأساسية للعمل في الخارج في البلدان ذات الدخل المنخفض. يجب على واضعي السياسات الارتقاء بالممارسات الجراحية بين أطباء الأسرة من خلال دعم برامج الطب الأسري، والتي تشمل تدريبًا على المهارات الجراحية الإضافية، ومن خلال توسيع الفرص والحوافز لطبيب الأسرة ليعمل في المناطق الريفية. وبالإضافة إلى ذلك، فإنه يجب أن تشتمل الخطط الجراحية الوطنية على استراتيجية للرعاية الصحية الأولية خاصة بالرعاية الجراحية، كما يجب على الصعيد العالمي وضع طبيب الأسرة في الاعتبار في نقاشات الرعاية الجراحية. وفي النهاية، يجب تشجيع الجراحين، وأطباء التخدير، وأطباء التوليد، وأطباء الأسرة، على التعاون لضمان حصول جميع المرضى، بغض النظر عن أماكن إقامتهم، على رعاية جراحية آمنة، وفي الوقت المناسب.初级卫生保健为在健全的卫生保健体系的基础上提供社会知情、全面的、以患者为中心的保健服务提供了框架，因此对实现全民健康覆盖至关重要。家庭医生最适合体现初级卫生保健对社区和人民卫生双重关注，因为他们通常受雇于人力资源有限的农村或地区医院，尤其缺乏专科医生。在此，我们想阐明对家庭医生（初级保健的主要临床医生）进行额外培训如何能够在缩小中低收入国家以及农村或偏远地区在获得外科、产科和麻醉护理的差距方面发挥关键作用。例如，如何在资源匮乏的环境下制定培训计划，以助家庭医生掌握挽救生命的手术技能，以及如何向高收入国家的家庭医生进行其在海外低收入国家工作所必需的外科技能培训。决策者应通过支持家庭医学计划（包括额外的外科技能培训）以及为家庭医生提供更多到农村地区服务的机会和激励措施，推动家庭医生的外科手术实践。此外，国家外科手术计划应涵盖外科手术护理的初级卫生保健战略，且全球各国在讨论外科手术治疗时都应将家庭医生考虑在内。最后，应鼓励外科医生、麻醉师、妇产科医生和家庭医生合作，以确保所有患者无论居住在哪，都可获得安全及时的手术护理。.Первичная медико-санитарная помощь обеспечивает основу для оказания социально информированной, комплексной и ориентированной на пациента помощи, лежащей в основе надежных систем здравоохранения, и поэтому играет центральную роль в достижении всеобщего охвата услугами здравоохранения. Семейные врачи наилучшим образом подходят для воплощения двойной ориентации первичной медико-санитарной помощи в вопросах здравоохранения сообщества и населения, поскольку они часто работают в сельских или районных больницах с ограниченными кадровыми ресурсами, в частности им недостает специалистов. Здесь мы хотим показать, как дополнительное обучение семейных врачей (основных врачей первичной медико-санитарной помощи) может сыграть решающую роль в сокращении неравенства доступа к хирургической, акушерской и анестезиологической помощи в странах с низким и средним уровнем доходов, а также в сельских или удаленных районах. Приведены примеры того, как можно разработать программы обучения в районах с низким уровнем ресурсов, чтобы вооружить семейных врачей хирургическими навыками, нужными для спасения жизни, и как семейные врачи в странах с высоким уровнем доходов могут обучаться хирургическим навыкам, необходимым для работы за границей в регионах с низким уровнем доходов. Лица, формирующие политику, должны продвигать хирургическую практику среди семейных врачей путем поддержки программ семейной медицины, которые включают дополнительное обучение хирургическим навыкам, а также путем расширения возможностей и стимулов для работы семейных врачей в сельских районах. Более того, национальные планы хирургической помощи должны включать стратегию первичной медико-санитарной помощи в отношении хирургической помощи, а в глобальном масштабе необходимо учитывать семейных врачей при обсуждении вопросов хирургической помощи. И наконец, следует поощрять к сотрудничеству хирургов, анестезиологов, акушеров и семейных врачей для обеспечения того, чтобы все пациенты, независимо от места проживания, получали безопасную и своевременную хирургическую помощь.

Introduction: Community-acquired pneumonia is an infectious disease with a global burden. Thrombocytopenia can be an effective and inexpensive tool in predicting the severity of pneumonia which can be useful in the primary care level. The objectives were to identify the clinical and laboratory predictors of hospitalized patients with pneumonia, determine the incidence of thrombocytopenia in those patients, its association with severity, compare it with leucocyte count, assess severity using clinical prediction scores, need of mechanical ventilation, need of transfer to intensive care unit and mortality. Methods: After informed consent, diagnosed and admitted cases of community-acquired pneumonia were examined after which patients' demographic and clinical data as well as laboratory parameters including white cell count and platelets were filled in proforma. Clinical prediction scores for pneumonia were calculated and the need for mechanical ventilation, inotropes, transfusions as well as mortality assessed. Patients were followed up until discharge to see the severity of pneumonia. Results: The incidence of thrombocytopenia among patients with pneumonia was 36.9% (41 out of 111). The overall mortality rate was 9%. More pneumonia patients having thrombocytopenia (14.6%) died than pneumonia patients having leukocytosis (13.8%). There was a significant association between thrombocytopenia and severity of pneumonia, both alone, (p = 0.007, OR = 4.03) and on adjusting for the WBC and GCS (p=0.017, OR = 3.81).Significant associations were found between thrombocytopenia and the need for ICU in patients with pneumonia (p=0.001), mechanical ventilation (p = 0.001), presence of edema, confusion, age variation (p=0.024) and septic shock (p=0.021). Conclusion: Thrombocytopenia can serve as an effective predictor of the severity of pneumonia.

The World Organization of Family Doctors (WONCA) is a not-for-profit organization and was founded in 1972 by member organizations in 18 countries. WONCA now has 118 Member Organizations in 131 countries and territories with a membership of about 500,000 family doctors and more than 90 percent of the world's population. WONCA has seven regions, each of which has its own regional Council and run their own regional activities including conferences. WONCA South Asia Region is constituted by the national academies and colleges and academic member organizations of this region namely India, Pakistan, Bangladesh, Nepal, Sri Lanka, Bhutan, and the Maldives. In the background of the ongoing COVID 19 pandemic, the office bearers, academic leaders, practitioners, and researchers of primary care from the South Asia Region have issued a solidarity statement articulating the role of primary care physicians.

Background: Chronic kidney disease is increasing day by day and so is condition of renal replacement therapy; mainly hemodialysis. Emergency visit of the patients under maintenance hemodialysis is frequent. The objective of the study is to study clinical parameters of these patients so that in future these deranged parameters can be focused during patient management and decrease their emergency visit. Methods: A prospective cross sectional study was conducted in emergency services of Tribhuvan University Teaching Hospital from 1st May 2018 to 31st October 2018 among the adult chronic kidney disease patients under maintenance hemodialysis. Ethical approval was taken from Institutional review board, Institute of medicine, TribhuvanUniversity.Nonprobability sampling method was used. Total of 300 patients were enrolled in the study. Patients’ age, sex, causes, laboratory parameter during emergency visit, need of emergency hemodialysis, and need of blood transfusion were studied. Results: Out of total 300 patients, mean age was 45.64 years (S.D =17.15). 190 (63.3 %) were male and 110(36.70%) were female. 152(50.70%) of patients had hypertension. Diabetes and Glomerulonephritis both had equal prevalence of 63(21%). Mean hemoglobin was 6.52gm% (S.D = 1.93). Mean pH was 7.17 (S.D =0.154). Mean serum potassium and creatinine level were 5.77 mEq/L (S.D =0.76) and 1076.03 mmol/l (S.D =367.25) respectively. Area under the Receiver Operating Curve was 0.660 for potassium and 0.598 for serum creatinine. Conclusions: Causes of chronic kidney disease, decreased hemoglobin level, increased serum creatinine and potassium level and metabolic acidosis are causes of frequent emergency room visit among CKD patients. So these conditions need to be addressed to decrease emergency visit of these patients. Keywords: chronic kidney disease; emergency presentation; mortality. DOI: http://doi.org/10.3126/jkahs.v2i2.25167

Introduction: Sepsis is a common problem encountered in emergency room which needs to be intervened early. It is always difficult to have quick prognostic marker of sepsis in busy emergency. So this study was conducted to determine whether base deficit can be used as an indicator of mortality among septic patients in emergency room setup like ours. Methods: It was a hospital based descriptive cross sectional study done at Tribhuvan University Teaching Hospital, Kathmandu from March 2018 to December 2018. Acute physiology and chronic health Evaluation II score (APACHE II), Base deficit, Sequential Organ Failure Assessment (SOFA) score on first day of arrival in emergency room was calculated. The association of 28-day outcome with acute physiology and chronic Health Evaluation II score, Base deficit value and SOFA score were derived. Results: Out of 229 patients with septic shock 62 died (27%) and among 71 patients without septic shock, 12 died (16.9%).Overall mortality was 24.66 % (n= 74).The area under the ROC curve for Base deficit(0.864;95% C.I.=0.822-0.906), APACHE II (0.782; 95% C.I=0.718-0.848, SOFA (0.689;95% C.I=0.620-0.757) were greater than 0.7 except for SOFA which signifies these test to have fair efficacy to predict mortality. Conclusions: High base deficit value predicts mortality in patients with sepsis and septic shock. The base deficit could be used as an alternate marker to predict mortality in septic patient. We recommend for large multicenter study with randomization so that the findings can be applied to general population and of different geographical situations.

Introduction: Upper gastrointestinal bleeding is a gastrointestinal emergency. It is characterized by hematemesis or melena or both. Rapid identification and stabilization of patients with upper gastrointestinal bleeding presenting to the emergency department is essential for patient survival. This study was done to inspect the use of the Clinical Rockall score to predict the outcome in patients with Upper gastrointestinal bleeding. Methods: A cross sectional study of 272 patients who presented to the emergency department of Tribhuvan University Teaching hospital within a period of one year with hematemesis or melena or both was performed. The Clinical Rockall Score was calculated for each patient based on the points assigned for clinical variables. Results: The most common cause of upper gastrointestinal bleeding was esophageal varices 86 (31.6%), followed by ulcers 53 (19.5%). Hematemesis was the most common mode of presentation in 133 (48.9%) followed by melaena in 95 (34.9%) and both in 44 (16.2%). High clinical Rockall score of >4 was associated with outcomes like transfusion in 81% patients, rebleeding in 61.9% and mortality in 69% of patients. The predictive accuracy of clinical Rockall score for transfusion, the AUROC was 0.737 (95% CI: 0.678-0.791, P=0.001); for rebleeding, the AUROC was 0.863 (95% CI: 0.8-0.927, P= 0.001) and for mortality, the AUROC was 0.877 (95% CI: 0.81-0.944, P= 0.001). Conclusions: Clinical Rockall Score is a simple and rapid non endoscopic risk score that can be applied at the time of presentation to the emergency department to predict mortality outcomes in patients with acute UGIB.

BACKGROUND: Limited number of studies has compared metformin with other Oral Hypoglycemic agents (OHAs) for reducing BMI and few of the results are controversial. Perhaps, this is of clinical importance because the Nepalese population presents different dietary habits in comparison with the European population. The objective of this study was to study the comparative evaluation of metformin with other OHAs influence on Body Mass Index (BMI) in Nepalese patients with diagnosed type 2 Diabetes Mellitus (T2DM)). METHODS: A prospective cross sectional database of patients treated at diabetic clinic, TUTH, was analysed. Patients (N = 115) with type 2 Diabetes Mellitus and with complete BMI and HbA1c and treated with metformin and other OHAs, for at least three visits were included. Analysis of BMI and the type of oral agent was performed. Individuals were categorized as ideal weight, overweight, or obese (BMI 30 kg/m2, respectively). RESULTS: There were differences between the values of BMI at presentation, the third, the sixth and the ninth months, between the metformin-treated groups compared to other OHAs treated groups. Metformin was given to 48 patients and OHAs to other 57 patients. In the metformin group, mean BMI decreased significantly during the treatment time, from 29.93±5.7 to 28.95±5.2 (

Negotiations about how to measure attainment of the proposed health targets of the Sustainable Development Goals seem a complex and politically fraught process. It is important that there are adequate indicators to measure health-system strengthening to achieve the proposed Sustainable Development Goal 3: ”ensure healthy lives and promote well-being for all at all ages”. The Millennium Development Goals stimulated admirable improvements in health in many countries. However, these goals have recognised shortcomings, particularly related to fragmentation of health systems and health inequities. Although condition-specifi c measures of health outcomes are important indicators, the risk of focusing on these measures is that policy makers and funders pursue vertically oriented approaches to health care when resources are scarce and stakeholders’ specific interests prevail. Measures of health-system strengthening, including structure and process measures, should form a core part of the post-2015 development agenda. There is strong evidence and broad agreement that primary care is central to health-system strengthening. If appropriately planned and delivered, it is person-centred with a populationbased approach. Primary care, including multidisciplinary team-based models of family practice, can serve as the regular entry point into health-care systems and meet most health-care needs, including disease prevention and health promotion. Primary care helps to establish and maintain healthy populations in equitable and effi cient ways, and is essential to achieve universal health coverage. To strengthen primary care, clear and explicit indicators that monitor progress are needed, which measure the distinctive dimensions that make this type of care eff ective. These dimensions include comprehensiveness, coordination, and continuity of care. Indicators must measure safety and quality of primary care, as well as integration with the rest of the health system and workforce development. Although challenging, examples of internationally validated methods exist, such as the Primary Care Assessment Tools. With a commitment to the collection of relevant data, indicators transferable to varying country contexts and stages of primary care development can be implemented. Crucially, to achieve greater investment in this area than that at present, measures of primary care expenditure as a proportion of total health expenditure are needed. Health systems founded on strong primary care are essential to achieve the Sustainable Development Goals. We call on the UN and all other stakeholders to show an unambiguous commitment to the measurement and development of high-quality, comprehensive primary care. We must aim for this commitment in all countries, irrespective of level of income, and cannot aff ord to wait another 15 years to do so.

Diabetes is one of the major public health problems in Nepal. Very few studies on correlation between waist hip ratio and random blood sugar have been done in remote areas of Nepal particularly in minor ethnic groups like Thami. This study attempted to compare waist hip ratio and blood sugar level in Thami community.This cross sectional study was conducted in sub-health post of Lapilang village of Dolakha district of Nepal. A total of 243 local inhabitants from Thami Tribe participated in the study. Waist hip ratio was calculated after taking measurements of waist and hip using flexible measuring tape; and, blood glucose level was measured by glucometer.The mean age of the participants was 46.02 years; among participants 126 (51.9%) were males and 117 (48.1%) were females. Mean waist hip ratio was 0.87, mean blood sugar level was 124.5 mg%. Increase in Waist hip ratio correlated significantly with increase in random blood sugar level both in males (p=0.008) and females (p=0.007).Increase in waist hip ratio is associated with increase in random blood sugar level. Therefore, there is a need of public awareness program to reduce waist circumference thus reducing weight of people to prevent development of diabetes mellitus in long run.

In troduction: Diabetes is one of the major public health problems in Nepal. Very few studies on correlation between waist hip ratio and random blood sugar have been done in remote areas of Nepal particularly in minor ethnic groups like Thami . This study attempted to compare waist hip ratio and blood sugar level in Thami community of Nepal. Methods: This cross sectional study was conducted in sub-health post of Lapilang village of Dolakha district of Nepal. A total of 243 local inhabitants from Thami Tribe participated in the study. Waist hip ratio was calculated after taking measurements of waist and hip using flexible measuring tape; and, blood glucose level was measured by glucometer. Results: The mean age of the participants was 46.02 years; among participants 126(51.9%) were males and 117(48.1%) were females. Mean waist hip ratio was 0.87, mean blood sugar level was 124.5mg%.Increase in Waist hip ratio correlated significantly with increase in random blood sugar level both in males(p=0.008) and females(p=0.007). Conclusions: Increase in waist hip ratio is associated with increase in random blood sugar level. Therefore, there is a need of public awareness program to reduce waist circumference thus reducing weight of people to prevent development of diabetes mellitus in long run. Keywords: blood sugar level; diabetes; Thami community; waist hip ratio

Introduction: Self-harm forms a significant proportion of patient attending in emergency departments, typically 10-30 per 100000 people commit suicide annually. The objective of this study was to find out the factors responsible for self harm. Methods: This is a cross sectional study of 100 patients of self harm coming to Emergency Department of Tribhuvan University Teaching Hospital from 1stOctober 2007 to 31stMarch, 2008. Questionnaire about demographic information of patient along with details about cause of self harm, and any other illnesses associated was filled. Information about duration of arrival in emergency department, place of self harm was gathered. Patients were clinically examined and hematological and biochemical tests including liver function test and the type of poison used and its level in blood were examined. Results: Total number of patients with self harm was 100 (female - 71%; male- 29%).Among female, 16-30 years age group to be the largest (76%). Mean duration of arrival in emergency department was 3.08 hour. Metacid ingestion (29%) was found to be the most common cause for self harm. There is no difference of self harm for suicide and threat cause. Only 5% of patient with self harm has psychiatry illness in the past. Conclusions: Self harm forms a significant proportion of patient attending the Emergency department and the most common form of self harm used was metacid ingestion. There is compelling evidence for the need to improve delivery of care for patients who inflict self harm. Key words: Cause; emergency department; self harm. DOI: http://dx.doi.org/10.3126/joim.v32i3.4954 Journal of Institute of Medicine , December, 2010; 32:3 14-17

INTRODUCTION: Pralidoxime are enzyme reactivator that are known to reactivate the phosphorylated acetylcholinesterase by binding to the organophosphorus molecule. The use of oximes in acute organophosphorus poisoning has been a controversial subjects for over two decades. This study was conducted with the objective to find out the estimation of serum cholinesterase and use of pralidoxime in organophosphorus poisoning. METHODS: A prospective analysis of all organophosphorus poisoning cases presented at the Emergency Department, Tribhuvan University Teaching Hospital for seven months was done. RESULTS: Out of 26 cases about 60% of poisoning cases were monitored for pseudocholinesterase level. About 50% of them had pseudocholinesterase level within normal limit and 20% had less than 10% of normal value. Only 33% cases with pseudocholinesterase level less than 10% were treated with pralidoxime. CONCLUSIONS: The initial dose of Pralidoxime used was 1 gm followed by maintenance dose of 500mg 6 hourly, the doses prescribed were less than WHO recommended doses. Keywords: cholinesterase, emergency, organophosphorus,poisoning, Pralidoxime.

The curriculum of the post graduate program in General Practice in Nepal is designed to develop comprehensive and effective health care as well as timely life-saving surgical services in the District Hospital. District hospitals in rural Nepal encounter many surgical emergencies. Most of the times, the patient can not afford to go to higher centers. General Practitioners (GPs) are effectively providing surgical services at district hospitals. The aim of this study is to focus the types of surgical cases that were managed by GP and establish the role and utilization of General Practice (GP) specialist as a surgeon at district, zonal and regional hospitals in developing countries. This is retrospective study of all cases at district hospital, Surkhet, (25 beds) of western part of Nepal during the period of one year (March 2000 to February 2001), that were managed by GPs. The surgical services provided by GP specialist at the district hospital were analyzed. A total of 16,975 cases were attended in the hospital during above period. Out of this, a total of 2,327(13.7%) were hospitalized. The total numbers of surgical cases were 1,205(51.8%). Out of this, 514(42.7%) cases had undergone surgery. The general surgery cases comprise 447(87.0%), Gynae / Obstetric and Orthopedic cases 67(13.0%). All surgeries were performed in limited resources by GPs. GP specialist can effectively manage the surgical cases and perform surgery at the district hospital competently. In country like Nepal, where number of surgical specialist are less and not available in majority hospitals, GPs can substitute the surgical specialist and provide emergency surgical services in urban areas (zonal and regional hospitals). Key Words: Surgery, Rural, General Practice, Nepal.