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Purpose: Genital lymphedema is a chronic debilitating condition associated with highly impaired health-related quality of life (QoL). This prospective multi-center study evaluated the use of a new compressive garment in patients with secondary and primary genital lymphedema. Methods: 32 patients prospectively enrolled were advised to wear the compressive garment for 12 weeks (day and night). The primary endpoint was change in patient-reported QoL at 12 weeks via the patient global impression of change (PGI-C) instrument. Secondary outcomes included change in other QoL measures at 12 weeks (VAS, LyQLI and EQ-5D questionnaires), lymphedema severity (Genital Lymphedema Score (GLS)) and physician assessment (Clinical Global Impression- Improvement (CGI-I)). Safety and tolerability were also assessed. Results: After 12 weeks, improvement was reported in 78.6% of patients (PGI-C). Physician assessment (CGI-I) indicated clinical improvement in 82.8% of patients. Patient assessment of lymphedema symptoms showed a significant decrease in discomfort (p = 0.02) and swelling (p = 0.01). Significant declines in mean global GLS scores (p < 0.0001), and in the proportion of patients reporting heaviness, tightness, swelling or urinary dysfunction (p < 0.05 for all) were also observed. LyQLI scores decreased (indicating improved QoL) in each of the physical, psychosocial (p = 0.05) and practical domains. The compressive garment was well tolerated with high compliance and adverse events (due to swelling or discomfort) led to permanent discontinuation in only 3 patients. Conclusions: Use of a new genital compression garment over 12 weeks improves QoL and clinical measures in patients with genital lymphedema (NCT04602559; Registration: 10/20/2020).

Autotaxin is a circulating enzyme with a major role in the production of lysophosphatic acid (LPA) species in blood. A role for the autotaxin/LPA axis has been suggested in many disease areas including pulmonary fibrosis. Structural modifications of the known autotaxin inhibitor lead compound 1, to attenuate hERG inhibition, remove CYP3A4 time-dependent inhibition, and improve pharmacokinetic properties, led to the identification of clinical candidate GLPG1690 (11). Compound 11 was able to cause a sustained reduction of LPA levels in plasma in vivo and was shown to be efficacious in a bleomycin-induced pulmonary fibrosis model in mice and in reducing extracellular matrix deposition in the lung while also reducing LPA 18:2 content in bronchoalveolar lavage fluid. Compound 11 is currently being evaluated in an exploratory phase 2a study in idiopathic pulmonary fibrosis patients.

BACKGROUND—Flu vaccination in otherwise healthy infants and young children is important to prevent severe disease, as well as to control epidemic spread of influenza infection. AIMS—To examine the safety and immunogenicity of a paediatric presentation of a purified, inactivated, triton split influenza vaccine. METHODS—Two doses of the vaccine, provided in prefilled syringes of 0.25 ml, were administered, one month apart, to 67 children under 3 years of age. RESULTS—Nine cases of immediate reaction to vaccination (macules/papules) were observed after the second injection only. During the study period, 9% of children experienced at least one delayed local reaction, and 28% of children presented at least one systemic reaction. Almost all reactions were mild and transient. Immunogenicity results surpassed the European Community recommendations for a 0.50 ml dose of vaccine in adults. CONCLUSION—This paediatric formulation of inactivated flu vaccine appears safe and immunogenic in children from 6 months to 3 years of age; the convenient presentation in a prefilled syringe of 0.25ml volume will facilitate administration of the dose recommended for young children.

This research concerns the development of an Negotiation Support Systems (NSS) based on a multi-criteria conceptual framework of the negotiation and developed according to a multi-agent architecture from Distributed Artificial Intelligence (DAI). A first prototype of such a system, NegocIAD, has already been developed [8], but the weakness of its assistance to the negotiation process have led us to revise the conceptual framework in order to define a more relevant assistance to the negotiation process. This paper presents this new conceptual framework defined in order to develop a new prototype. First, we point out the originality of our multi-criteria and multi-agent approach, the general architecture and the limitations of NegocIAD. Then we present the new multi-criteria conceptual framework mainly based on the definition and the use of projection plans (group Gaia plans) emerging from principal component analysis (PCA) already proposed in a single decision maker context in extension of the Promethee method. In the next part, we develop the possible levels of use of these plans during the negotiation process and the type of assistance provided to the mediator. This assistance is mainly based on the elaboration and the interpretation of group Gaia plans for which we propose a set of interpretation rules and the outline of a method to make use of these rules for a relevant support to the mediator in the management of the negotiation process. Finally, we conclude on the perspectives of our future researches and developments for the new generation of our prototype in a multi-agent architecture context.

A total of 1290 patients were enrolled in a randomized multicentre double blind study in order to investigate the use of two doses of a new low molecular weight heparin, Logiparin®, in the prevention of deep vein thrombosis (DVT) in general surgery. Patients who were included had no contraindication to heparin therapy and had at least one of the recognized risk factors for DVT. Patients were randomized to receive unfractionated heparin (UH) 5000 units b.d., Logiparin 2500 units daily or Logiparin 3500 units daily. Each treatment was given subcutaneously 2h before surgery and continued for 7–10 days. Daily 125I-labelled fibrinogen uptake tests (FUTs) were performed from day 2 to day 7 to detect DVT, and phleboangiography was used to confirm the diagnosis. The wound was examined on a daily basis to check for haematoma formation, and all patients were followed up for 1 month after operation. All three treatment arms were well matched for age, sex, weight, diagnosis and type of operation performed. The three major inclusion criteria in the trial were malignancy, age over 60 years and a history of varicose veins. Positive FUTs (UH=4·2 per cent, Logiparin 2500 units daily = 7·9 per cent, Logiparin 3500 units daily = 3·7 per cent) and positive angiograms (UH=3·0 per cent, Logiparin 2500 units daily = 5·6 per cent, Logiparin 3500 units daily = 2·3 per cent) were significantly more common in the Logiparin 2500 units daily group than in the UH and Logiparin 3500 units daily groups. The rates of major complications (severe haemorrhage, death, pulmonary embolism, reintervention) were similar in the three groups.

Picolet Guy. Une visite du jeune Saint-Simon à l'Observatoire de Paris. In: Cahiers Saint Simon, n°26, 1998. Ecrivains lecteurs des Mémoires pp. 59-68.

A combined experimental and theoretical study is here presented on the structure of genipin, a widely used molecule, whose applications range from natural cross-linker for proteins to regulating agent for drug delivery to precursor of natural dye. In particular the tridimensional structure of the genipin in solution has been studied by NMR spectroscopy and the experimental outcomes have been then supported by Density Functional Theory (DFT) calculations on the electronic structure and spectroscopic parameters. The equilibrium between open and closed-ring tautomers of genipin in solution has been also theoretically investigated. The mechanism of ring opening has been elucidated and the catalytic role of water has been clearly shown. Beyond the excellent agreement between experiments and theoretical calculations (in particular concerning 1H-NMR data), our results unravel the nature of the most stable isomer of genipin and related reactive species in solution.

A music emulator for emulating guitar sounds uses non-guitar like devices, as for instance a piano style keyboard, for input. Input from the keyboard within a time window is defined as simultaneous and entered into a note list. A signal is derived from the note list indicative of the chord played on the keyboard. In addition, notes in the note list can be extended to form a full chord whereby as few as three notes constituting a chord input at the keyboard are extended to a greater number of notes as, for instance, the six strings of a guitar. This signal is then outputted at a time rate which is extended with respect to the input time window whereby the output emulates a guitar strum including an arpeggiation or strumming effect of a guitar like sound. Chord extension is achieved by analyzing the notes in the note list as to their pitch and generating further notes which are outside the typical one octave range of a keyboard chord and extend to the typical four octave window of a guitar.

On montre que l'ordre d'exposition des idées du chapitre II du livre Γ des Météorologiques d'Aristote n'est pas satisfaisant, à cause de la place qu'y occupe le paragraphe sur l'arc-en-ciel lunaire (372 a 21-29). Ce passage, qui est probablement une adjonction tardive opérée par Aristote lui-même, devait primitivement être rattaché à l'exposition des faits relatifs à l'arc-en-ciel solaire (371 b 26-372 a 10), soit qu'il ait constitué une incise à l'intérieur de celle-ci (en 371 b 32), soit plutôt un appendice qui la suivait immédiatement (en 372 a 10)., Picolet Guy. Un paragraphe déplacé dans les « Météorologiques » d'Aristote (372 à 21-29). In: Revue des Études Anciennes. Tome 76, 1974, n°3-4. pp. 232-236.

SUMMARY. — Once again historians of science and technology are asked to appreciate the importance of the documents preserved in the Minutier central in Paris. To illustrate the usefulness of the Minutier central, the authors publish an extract from the inventory after death of the physicist Jacques Rohault, which enumerates the books and scientific instruments found in his home in February 1673. In the foot-notes they try to identify the books mentioned and describe the instruments listed in the inventory. The article ends with a few remarks on Rohaulťs library and scientific instruments., RÉSUMÉ. — L'attention des historiens des sciences et des techniques est une nouvelle fois attirée sur les ressources du Minutier central de Paris. On donne ensuite, à titre d'exemple d'utilisation, un extrait de l'inventaire après décès du physicien Jacques Rohault, concernant les livres et les instruments scientifiques qui ont été trouvés à son domicile après sa mort. Un essai d'identification de chacun des ouvrages cités dans l'inventaire, ainsi qu'une description sommaire des différents instruments mentionnés sont fournis en note. Quelques remarques sur la bibliothèque et les instruments scientifiques de Rohault concluent l'article., Mc Claughlin Trevor, Picolet Guy. Un exemple d'utilisation du Minutier central de Paris : la bibliothèque et les instruments scientifiques du physicien Jacques Rohault selon son inventaire après décès.. In: Revue d'histoire des sciences, tome 29, n°1, 1976. pp. 3-20.

RÉSUMÉ. — Historique des relations épistolaires de Jean Picard (1620- 1682) avec Johann Hevelius (1611-1687), puis édition, traduction française et annotation des six lettres latines échangées par les deux astronomes de 1671 à 1679.

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PFC fet a la empresa Amadeus a les oficines de Londres. El projecte consisteix en fer un sistema d'informació que ajudi en la presa de decisions a certs membres de l'empresa (units managers i head departments).