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1. Effect of haemodiafiltration vs conventional haemodialysis on growth and cardiovascular outcomes in children – the HDF, heart and height (3H) study

Author

Shroff, Rukshana, Bayazit, Aysun, Stefanidis, Constantinos J., Askiti, Varvara, Azukaitis, Karolis, Canpolat, Nur, Agbas, Ayse, Anarat, Ali, Aoun, Bilal, Bakkaloglu, Sevcan, Bhowruth, Devina, Borzych-Dużałka, Dagmara, Bulut, Ipek Kaplan, Büscher, Rainer, Dempster, Claire, Duzova, Ali, Habbig, Sandra, Hayes, Wesley, Hegde, Shivram, Krid, Saoussen, Licht, Christoph, Litwin, Mieczyslaw, Mayes, Mark, Mir, Sevgi, Nemec, Rose, Obrycki, Lukasz, Paglialonga, Fabio, Picca, Stefano, Ranchin, Bruno, Samaille, Charlotte, Shenoy, Mohan, Sinha, Manish, Smith, Colette, Spasojevic, Brankica, Vidal, Enrico, Vondrák, Karel, Yilmaz, Alev, Zaloszyc, Ariane, Fischbach, Michel, Schaefer, Franz, and Schmitt, Claus Peter

Published
2018
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3. Primary hyperoxaluria Type 1: indications for screening and guidance for diagnosis and treatment

Author

Cochat, Pierre, Hulton, Sally-Anne, Acquaviva, Cécile, Danpure, Christopher J., Daudon, Michel, De Marchi, Mario, Fargue, Sonia, Groothoff, Jaap, Harambat, Jérôme, Hoppe, Bernd, Jamieson, Neville V., Kemper, Markus J., Mandrile, Giorgia, Marangella, Martino, Picca, Stefano, Rumsby, Gill, Salido, Eduardo, Straub, Michael, and van Woerden, Christiaan S.

Published
2012
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5. Low levels of urinary epidermal growth factor predict chronic kidney disease progression in children

Author

Mir, Sevgi, Hohbach-Hohenfellner, Katharina, Jeck, Nickola, Smith, Michelle, Klaus, Guenter, Ardissino, Gianluigi, Testa, Sara, Montini, Giovanni, Charbit, Marina, Niaudet, Patrick, Afonso, Alberto Caldas, Fernandes-Teixeira, Ana, Peruzzi, Licia, Arbeiter, Klaus, Jankauskiene, Augustina, Grenda, Ryszard, Litwin, Mieczyslaw, Neuhaus, Thomas J., Fang, Zhiyin, Dusek, Jiri, Matteucci, Chiara, Azukaitis, Karolis, Picca, Stefano, Ju, Wenjun, Thurn-Valsassina, Daniela, Kirchner, Marietta, Wigger, Marianne, Berg, Ulla B., Celsi, Giovanni, Fischbach, Michel, Terzic, Joelle, Vidal, Enrico, TABEL, YILMAZ, Gimpel, Charlotte, ERTAN, PELİN, Yavascan, Onder, Melk, Anette, Querfeld, Uwe, Wuehl, Elke, Kretzler, Matthias, Schaefer, Franz, Rosales, Alejandra, Zaloszyc, Ariane, Gellermann, Jutta, Liebau, Max, Weber, Lutz, Muschiol, Evelin, Buescher, Rainer, Oh, Jun, Thurn-Valassina, Daniela, Haffner, Dieter, John, Ulrike, Wygoda, Simone, Jeck, Nikola, Murer, Luisa, Drozdz, Dorota, Coppo, Rosanna, Lugani, Francesca, Zurowska, Aleksandra, Zaniew, Marcin, Nimierska, Anna, Teixeira, Ana, Peco-Antic, Amira, Laube, Guido, Dali, Cocuk Nefrolojisi Bilim, Anarat, Ali, Bayazit, Aysun, DÜZOVA, ALİ, BİLGİNER, YELDA, ÇALIŞKAN, Salim, CANPOLAT, Nur, Civilibal, Mahmut, Shroff, Rukshana, Soezeri, Betul, Kranz, Brigitta, Mencarelli, Francesca, Dorn, Brigitte, Nair, Viji, Yalcinkaya, Fatos, Baskin, Esra, Cakar, Nilgun, Soylemezoglu, Oguz, Emre, Sevinc, Candan, Cengiz, Kiyak, Aysel, Ozcelik, Gul, Alpay, Harika, Rachin, Bruno, Szczepanska, Maria, Erdogan, Hakan, DÖNMEZ, OSMAN, Balat, Ayse, Aksu, Nejat, Tabel, Yilmaz, Ertan, Pelin, Yilmaz, Ebru, Bakkaloglu, Aysin, ÖZALTIN, FATİH, Sallay, Peter, Bonzel, Klaus-Eugen, Wingen, Anna-Margrete, Urowska, Aleksandra Z., Balasz, Irena, Trivelli, Antonella, Perfumo, Francesco, Mueller-Wiefel, Dirk-Erhard, Moeller, Kerstin, Offner, Gisela, Enke, Barbara, Hadtstein, Charlotte, Mehls, Otto, Fydryk, Janusz, Urasinski, Tomasz, KARABAY BAYAZIT, AYSUN, Niemirska, Anna, KAPLAN BULUT, İPEK, Paripovic, Dusan, Harambat, Jerome, ÇAKAR, NİLGÜN, ALPAY, HARİKA, Çukurova Üniversitesi, Bursa Uludağ Üniversitesi/Tıp Fakültesi/Dahili Tıp Bilimleri/Çocuk Sağlığı ve Hastalıkları Ana Bilim Dalı., Dönmez, Osman, AAA-8778-2021, Clinic of Pediatrics, Institute of Clinical Medicine, Faculty of Medicine, Vilnius University, Vilnius, Lithuania, Department of Internal Medicine/Nephrology, University of Michigan, Ann Arbor, MI, United States, Department of Computational Medicine and Bioinformatics, University of Michigan, Ann Arbor, MI, United States, Institute of Medical Biometry and Informatics, University of Heidelberg, Heidelberg, Germany, Department of Kidney, Liver and Metabolic Diseases, Hannover Medical School, Hannover, Germany, Department of Pediatric Nephrology, Cukurova University, Adana, Turkey, Department of Nephrology, Kidney Transplantation and Arterial Hypertension, The Children`s Memorial Health Institute, Warsaw, Poland, Department of Pediatric Nephrology, Istanbul University Cerrahpasa Faculty of Medicine, Istanbul, Turkey, Division of Pediatric Nephrology, Department of Pediatrics, Ege University Faculty of Medicine, Izmir, Turkey, Division of Pediatric Nephrology, Department of Pediatrics, School of Medicine, Ankara University, Ankara, Turkey, Department of Pediatric Nephrology, University Children's Hospital, Belgrade, Serbia, Department of Pediatrics, Bordeaux University Hospital, Bordeaux, France, Department of Pediatric Nephrology, Marmara University Faculty of Medicine, Istanbul, Turkey, Division of Nephrology, Dialysis, Transplantation, University of Genoa, G. Gaslini Institute, Genoa, Italy, Pediatric Nephrology Unit, Department of Pediatrics, S.Orsola-Malpighi Hospital, University of Bologna, Bologna, Italy, Department of Pediatric Nephrology, Haseki Educational and Research Hospital, Istanbul, Turkey, Department of Pediatric Nephrology, Bursa Yuksek Ihtisas Teaching and Researching Hospital, Bursa, Turkey, Pediatric Nephrology, Charité Children's Hospital, Berlin, Germany, Pediatric Nephrology, Dialysis and Transplantation Unit, Department of Woman's and Child's Health, University-Hospital of Padova, Padova, Italy, Department of Pediatric Nephrology, Faculty of Medicine, İnönü University, Malatya, Turkey, Department of General Pediatrics, Adolescent Medicine and Neonatology, Medical Center, Faculty of Medicine, University of Freiburg, Freiburg, Germany, Department of Pediatric Nephrology, Celal Bayar University, Manisa, Turkey, Department of Pediatric Nephrology, University of Health Sciences, İzmir Tepecik Training and Research Hospital, İzmir, Turkey, Department of Pediatric Nephrology, Charité University, Berlin, Germany, and Division of Pediatric Nephrology, Center for Pediatrics and Adolescent Medicine, Heidelberg University Hospital, Heidelberg, Germany

Subjects
Male, 0301 basic medicine, Chronic kidney failure, Physiology, Protein function, Medizin, 030232 urology & nephrology, Comorbidity, Urine, urologic and male genital diseases, Gastroenterology, 0302 clinical medicine, Pathology, Urology & nephrology, Estimated glomerular filtration rate, Disease course, pediatric CKD, Child, Priority journal, Kidney, female genital diseases and pregnancy complications, CKD progression, chronic kidney disease, epidermal growth factor, 3. Good health, Risk-factors, Proteinuria, medicine.anatomical_structure, Nephrology, Systolic blood pressure, Glomerulus filtration rate, Biomarker (medicine), Female, Glomerular filtration rate, Cohort analysis, Age factors, Human, medicine.medical_specialty, Adolescent, Urinary system, Excretion, Predictive value, Renal function, Follow-up studies, Major clinical study, Urinalysis, Pathophysiology, Article, Roles, 03 medical and health sciences, Age, Internal medicine, Post-hoc analysis, medicine, Humans, Predictive value of tests, Post hoc analysis, Renal insufficiency, chronic, Prospective study, Disease exacerbation, Egf, Disease progression, Renal replacement therapy, business.industry, Follow up, medicine.disease, Glomerulopathy, Chronic Kidney Failure, Kidney Diseases, Young-adults, Biological marker, 030104 developmental biology, Risk factors, Risk factor, Prediction, business, Prospective studies, Controlled study, Biomarkers, Kidney disease
Abstract

PubMedID: 31005273 Urinary epidermal growth factor (uEGF) has recently been identified as a promising biomarker of chronic kidney disease (CKD) progression in adults with glomerular disease. Low levels of uEGF predict CKD progression and appear to reflect the extent of tubulointerstitial damage. We investigated the relevance of uEGF in pediatric CKD. We performed a post hoc analysis of the Cardiovascular Comorbidity in Children with CKD (4C) study, which prospectively follows children aged 6–17 years with baseline estimated glomerular filtration rate (eGFR) of 10–60 ml/min/1.73 m2. uEGF levels were measured in archived urine collected within 6 months of enrollment. Congenital abnormalities of the kidney and urinary tract were the most common cause of CKD, with glomerular diseases accounting for

Published
2019

6. Effects of Hemodiafiltration versus Conventional Hemodialysis in Children with ESKD: The HDF, Heart and Height Study

Author

Shroff, Rukshana, Smith, Colette, Ranchin, Bruno, Bayazit, Aysun K., Stefanidis, Constantinos J., Askiti, Varvara, Azukaitis, Karolis, Canpolat, Nur, Agba, Ayşe, Aitkenhead, Helen, Anarat, Ali, Aoun, Bilal, Aofolaju, Daley, Bakkaloglu, Sevcan Azime, Bhowruth, Devina, Borzych-Duza, Dagmara, Bulut, Ipek Kaplan, Büscher (R.), Rainer, Deanfield, John, Dempster, Claire, Duzova, Ali, Habbig, Sandra, Hayes, Wesley, Hegde, Shivram, Krid, Saoussen, Licht, Christoph, Litwin, Mieczyslaw, Mayes, Mark, Mir, Sevgi, Nemec, Rose, Obrycki, Lukasz, Paglialonga, Fabio, Picca, Stefano, Samaille, Charlotte, Shenoy, Mohan, Sinha, Manish D., Spasojevic, Brankica, Stronach, Lynsey, Vidal, Enrico, Vondrák, Karel, Yilmaz, Alev, Zaloszyc, Ariane, Fischbach, Michel, Schmitt, Claus Peter, Schaefer, Franz, Ağbaş, Ayşe, Borzych-Dużałka, Dagmara, Çukurova Üniversitesi, İÜC, Cerrahpaşa Tıp Fakültesi, Dahili Tıp Bilimleri Bölümü, and Ege Üniversitesi

Subjects
Male, medicine.medical_treatment, 030232 urology & nephrology, Medizin, Blood Pressure, 030204 cardiovascular system & hematology, Carotid Intima-Media Thickness, law.invention, Kidney Failure, Hemoglobins, 0302 clinical medicine, Randomized controlled trial, law, cardiovascular disease, Chronic, Child, hemodialysis, integumentary system, Headache, General Medicine, Hospitalization, C-Reactive Protein, Nephrology, Parathyroid Hormone, Child, Preschool, Cohort, Hypertension, Cardiology, Female, Hemodialysis, carotid intima-media thickness, children, growth, hemodiafiltration (HDF), Adolescent, Dizziness, Humans, Kidney Failure, Chronic, Muscle Cramp, Patient Reported Outcome Measures, Phosphates, Renal Dialysis, Young Adult, beta 2-Microglobulin, Body Height, Hemodiafiltration, medicine.medical_specialty, Mean arterial pressure, Renal function, 03 medical and health sciences, Clinical Research, Internal medicine, medicine, Preschool, Dialysis, business.industry, Propensity score matching, Observational study, business
Abstract

EgeUn###, Background Hypertension and cardiovascular disease are common in children undergoing dialysis. Studies suggest that hemodiafiltration (HDF) may reduce cardiovascular mortality in adults, but data for children are scarce. Methods The HDF, Heart and Height study is a nonrandomized observational study comparing outcomes on conventional hemodialysis (HD) versus postdilution online HDF in children. Primary outcome measures were annualized changes in carotid intima-media thickness (cIMT) SD score and height SD score. Results We enrolled 190 children from 28 centers; 78 on HD and 55 on HDF completed 1-year follow-up. The groups were comparable for age, dialysis vintage, access type, dialysis frequency, blood flow, and residual renal function. At 1 year, cIMT SD score increased significantly in children on HD but remained static in the HDF cohort. On propensity score analysis, HD was associated with a +0.47 higher annualized cIMT SD score compared with HDF. Height SD score increased in HDF but remained static in HD. Mean arterial pressure SD score increased with HD only. Factors associated with higher cIMT and mean arterial pressure SD-scores were HD group, higher ultrafiltration rate, and higher 2-microglobulin. The HDF cohort had lower 2-microglobulin, parathyroid hormone, and high-sensitivity C-reactive protein at 1 year; fewer headaches, dizziness, or cramps; and shorter postdialysis recovery time. Conclusions HDF is associated with a lack of progression in vascular measures versus progression with HD, as well as an increase in height not seen in the HD cohort. Patient-related outcomes improved among children on HDF correlating with improved BP control and clearances. Confirmation through randomized trials is required., National Institute for Health ResearchNational Institute for Health Research (NIHR); Kidney Research UKKidney Research UK (KRUK); Fresenius Medical Care, R.S. holds a Career Development Fellowship with the National Institute for Health Research. The 3H study was sponsored by Kidney Research UK. Part sponsorship was obtained from Fresenius Medical Care.

Published
2018

9. Low levels of urinary epidermal growth factor predict chronic kidney disease progression in children

Author

Azukaitis, Karolis, primary, Ju, Wenjun, additional, Kirchner, Marietta, additional, Nair, Viji, additional, Smith, Michelle, additional, Fang, Zhiyin, additional, Thurn-Valsassina, Daniela, additional, Bayazit, Aysun, additional, Niemirska, Anna, additional, Canpolat, Nur, additional, Bulut, Ipek Kaplan, additional, Yalcinkaya, Fatos, additional, Paripovic, Dusan, additional, Harambat, Jerome, additional, Cakar, Nilgun, additional, Alpay, Harika, additional, Lugani, Francesca, additional, Mencarelli, Francesca, additional, Civilibal, Mahmut, additional, Erdogan, Hakan, additional, Gellermann, Jutta, additional, Vidal, Enrico, additional, Tabel, Yilmaz, additional, Gimpel, Charlotte, additional, Ertan, Pelin, additional, Yavascan, Onder, additional, Melk, Anette, additional, Querfeld, Uwe, additional, Wühl, Elke, additional, Kretzler, Matthias, additional, Schaefer, Franz, additional, Arbeiter, Klaus, additional, Rosales, Alejandra, additional, Dusek, Jiri, additional, Zaloszyc, Ariane, additional, Liebau, Max, additional, Weber, Lutz, additional, Muschiol, Evelin, additional, Büscher, Rainer, additional, Oh, Jun, additional, Thurn-Valassina, Daniela, additional, Haffner, Dieter, additional, John, Ulrike, additional, Wygoda, Simone, additional, Jeck, Nikola, additional, Wigger, Marianne, additional, Testa, Sara, additional, Murer, Luisa, additional, Matteucci, Chiara, additional, Jankauskiene, Augustina, additional, Azukaitis, Karolis, additional, Drozdz, Dorota, additional, Zurowska, Aleksandra, additional, Zaniew, Marcin, additional, Litwin, Mieczyslaw, additional, Nimierska, Anna, additional, Teixeira, Ana, additional, Peco-Antic, Amira, additional, Laube, Guido, additional, Anarat, Ali, additional, Duzova, Ali, additional, Bilginer, Yelda, additional, Caliskan, Salim, additional, Mir, Sevgi, additional, Sözeri, Betül, additional, Kranz, Brigitta, additional, Dorn, Brigitte, additional, Baskin, Esra, additional, Soylemezoglu, Oguz, additional, Emre, Sevinc, additional, Candan, Cengiz, additional, Kiyak, Aysel, additional, Ozcelik, Gul, additional, Shroff, Rukshana, additional, Rachin, Bruno, additional, Szczepanska, Maria, additional, Donmez, Osman, additional, Balat, Ayse, additional, Aksu, Nejat, additional, Yilmaz, Ebru, additional, Bakkaloglu, Aysin, additional, Ozaltin, Fatih, additional, Sallay, Peter, additional, Drożdż, Dorota, additional, Bonzel, Klaus-Eugen, additional, Wingen, Anna-Margrete, additional, Żurowska, Aleksandra, additional, Balasz, Irena, additional, Trivelli, Antonella, additional, Perfumo, Francesco, additional, Müller-Wiefel, Dirk-Erhard, additional, Möller, Kerstin, additional, Offner, Gisela, additional, Enke, Barbara, additional, Hadtstein, Charlotte, additional, Mehls, Otto, additional, Hohbach-Hohenfellner, Katharina, additional, Jeck, Nickola, additional, Klaus, Günter, additional, Ardissino, Gianluigi, additional, Montini, Giovanni, additional, Charbit, Marina, additional, Niaudet, Patrick, additional, Afonso, Alberto Caldas, additional, Fernandes-Teixeira, Ana, additional, Dušek, Jiri, additional, Picca, Stefano, additional, Berg, Ulla B., additional, Celsi, Giovanni, additional, Fischbach, Michel, additional, Terzic, Joelle, additional, Fydryk, Janusz, additional, Urasinski, Tomasz, additional, Coppo, Rosanna, additional, Peruzzi, Licia, additional, Grenda, Ryszard, additional, and Neuhaus, Thomas J., additional

Published
2019
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10. Effects of Hemodiafiltration versus Conventional Hemodialysis in Children with ESKD: The HDF, Heart and Height Study

Author

Shroff, Rukshana, primary, Smith, Colette, additional, Ranchin, Bruno, additional, Bayazit, Aysun K., additional, Stefanidis, Constantinos J., additional, Askiti, Varvara, additional, Azukaitis, Karolis, additional, Canpolat, Nur, additional, Ağbaş, Ayşe, additional, Aitkenhead, Helen, additional, Anarat, Ali, additional, Aoun, Bilal, additional, Aofolaju, Daley, additional, Bakkaloglu, Sevcan Azime, additional, Bhowruth, Devina, additional, Borzych-Dużałka, Dagmara, additional, Bulut, Ipek Kaplan, additional, Büscher, Rainer, additional, Deanfield, John, additional, Dempster, Claire, additional, Duzova, Ali, additional, Habbig, Sandra, additional, Hayes, Wesley, additional, Hegde, Shivram, additional, Krid, Saoussen, additional, Licht, Christoph, additional, Litwin, Mieczyslaw, additional, Mayes, Mark, additional, Mir, Sevgi, additional, Nemec, Rose, additional, Obrycki, Lukasz, additional, Paglialonga, Fabio, additional, Picca, Stefano, additional, Samaille, Charlotte, additional, Shenoy, Mohan, additional, Sinha, Manish D., additional, Spasojevic, Brankica, additional, Stronach, Lynsey, additional, Vidal, Enrico, additional, Vondrák, Karel, additional, Yilmaz, Alev, additional, Zaloszyc, Ariane, additional, Fischbach, Michel, additional, Schmitt, Claus Peter, additional, and Schaefer, Franz, additional

Published
2019
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12. NORMAL 25-HYDROXYVITAMIN D LEVELS ARE ASSOCIATED WITH LESS PROTEINURIA AND ATTENUATE RENAL FAILURE PROGRESSION IN CHILDREN WITH CHRONIC KIDNEY DISEASE

Author

Shroff, Rukshana, Trivelli, Antonella, Litwin, Mieczyslaw, Picca, Stefano, Anarat, Ali, Sallay, Peter, Ozaltin, Fatih, and Çukurova Üniversitesi

Subjects
urologic and male genital diseases
Abstract

52nd Congress of the European-Renal-Association-European-Dialysis-and-Transplant-Assocation -- MAY 28-31, 2015 -- London, ENGLAND WOS: 000361215100331 … European Renal Assoc, European Dialysis & Transplant Assoc

Published
2015

13. Normal 25-Hydroxyvitamin D Levels Are Associated with Less Proteinuria and Attenuate Renal Failure Progression in Children with CKD

Author

Shroff, Rukshana, primary, Aitkenhead, Helen, additional, Costa, Nikola, additional, Trivelli, Antonella, additional, Litwin, Mieczyslaw, additional, Picca, Stefano, additional, Anarat, Ali, additional, Sallay, Peter, additional, Ozaltin, Fatih, additional, Zurowska, Aleksandra, additional, Jankauskiene, Augustina, additional, Montini, Giovanni, additional, Charbit, Marina, additional, Schaefer, Franz, additional, and Wühl, Elke, additional

Published
2016
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15. FP282NORMAL 25-HYDROXYVITAMIN D LEVELS ARE ASSOCIATED WITH LESS PROTEINURIA AND ATTENUATE RENAL FAILURE PROGRESSION IN CHILDREN WITH CHRONIC KIDNEY DISEASE

Author

Shroff, Rukshana, primary, Trivelli, Antonella, additional, Litwin, Mieczyslaw, additional, Picca, Stefano, additional, Anarat, Ali, additional, Sallay, Peter, additional, Ozaltin, Fatih, additional, Zurowska, Aleksandra, additional, Jankauskiene, Augustina, additional, Montini, Giovanni, additional, Charbit, Marina, additional, Schaefer, Franz, additional, and Wühl, Elke, additional

Published
2015
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17. Reduced Systolic myocardial chronic renal insufficiency

Author

Chinali, Marcello, de Simone, Giovanni, Matteucci, Maria Chiara, Picca, Stefano, Mastrostefano, Antonio, Anarat, Ali, Qaliskan, Salim, and Çukurova Üniversitesi

Abstract

WOS: 000243917300029 PubMed ID: 17215443 Increased left ventricular (LV) mass in children with chronic renal insufficiency (CRI) might be adaptive to sustain myocardial performance in the presence of increased loading conditions. It was hypothesized that in children with CRI, LV systolic function is impaired despite increased LV mass (LVM). Standard echocardiograms were obtained in 130 predialysis children who were aged 3 to 18 yr (59% boys) and had stages II through IV chronic kidney disease and in 130 healthy children of similar age, gender distribution, and body build. Systolic function was assessed by measurement of fractional shortening at the endocardial (eS) and midwall (mS) levels and computation of end-systolic stress (myocardial afterload). The patients with CRI exhibited a 6% lower eS (33.1 +/- 5.5 versus 35.3 +/- 6.1%; P < 0.05) and 10% lower mS (17.8 +/- 3.1 versus 19.7 +/- 2.7%; P < 0.001) than control subjects in the presence of significantly elevated BP, increased LVM, and more concentric LV geometry. Whereas the decreased eS was explained entirely by augmented end-systolic stress, mS remained reduced after correction for myocardial afterload. The prevalence of subclinical systolic dysfunction as defined by impaired mS was more than five-fold higher in patients with CRI compared with control subjects (24.6 versus 4.5%; P < 0.001). Systolic dysfunction was most common (48%) in patients with concentric hypertrophy and associated with lower hemoglobin levels. CRI in children is associated with impaired intrinsic LV contractility, which parallels increased LVM.

Published
2007

19. Anterior ischemic optical neuropathy in children on chronic peritoneal dialysis: report of 7 cases.

Author

Di Zazzo G, Guzzo I, De Galasso L, Fortunato M, Leozappa G, Peruzzi L, Vidal E, Corrado C, Verrina E, Picca S, and Emma F

Subjects
Child, Child, Preschool, Female, Humans, Hypotension etiology, Infant, Kidney Failure, Chronic complications, Male, Retrospective Studies, Kidney Failure, Chronic therapy, Optic Neuropathy, Ischemic diagnosis, Optic Neuropathy, Ischemic etiology, Peritoneal Dialysis adverse effects
Abstract

Background: Anterior ischemic optic neuropathy (AION) is characterized by infarction of the optic nerve head due to hypoperfusion of the posterior ciliary arteries and causes sudden blindness in adults on chronic dialysis, but has rarely been described in children. Unlike adults, children do not have comorbidities related to aging., Methods: We retrospectively analyzed data of 7 children on nocturnal continuous cycling peritoneal dialysis (CCPD) who developed AION identified within the Italian Registry of Pediatric Chronic Dialysis. We also summarized data from 10 cases reported in the literature., Results: Our 7 patients suffered from acute onset bilateral blindness. Their mean age was 3.2 years and chronic hypotension had been observed prior the AION in 3 of the 7 children. Low systolic blood pressure (SBP) was associated with higher risk of developing AION according to statistical analysis. None recovered completely. In total, 11 out of 16 experienced a partial recovery and no clear evidence emerged favoring specific treatments., Conclusions: Hypotensive children treated with CCPD are at increased risk of developing AION, which often results in irreversible blindness., (Copyright © 2015 International Society for Peritoneal Dialysis.)

Published
2015
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