98 results on '"Ossemann, Michel"'
Search Results
2. Development of an electronic decision tool to support appropriate treatment choice in adult patients with epilepsy – Epi-Scope®
- Author
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Legros, Benjamin, Boon, Paul, Ceulemans, Berten, Coppens, Thomas, Geens, Karine, Hauman, Henri, Lagae, Lieven, Meurs, Alfred, Mol, Leon, Ossemann, Michel, van Rijckevorsel, Kenou, Van Zandijcke, Michel, Vrielynck, Pascal, Wagemans, Daniëlla, and Grisar, Thierry
- Published
- 2012
- Full Text
- View/download PDF
3. Transcranial doppler assessment of cerebral perfusion in critically ill septic patients: a pilot study
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Pierrakos, Charalampos, Antoine, Aurélie, Velissaris, Dimitrios, Michaux, Isabelle, Bulpa, Pierre, Evrard, Patrick, Ossemann, Michel, and Dive, Alain
- Published
- 2013
- Full Text
- View/download PDF
4. Longitudinally extensive transverse myelitis following acute COVID-19 infection.
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UCL - SSS/IREC/MONT - Pôle Mont Godinne, UCL - (MGD) Service de neurologie, Fumery, Thibault, Baudar, Coline, Ossemann, Michel, London, Frédéric, UCL - SSS/IREC/MONT - Pôle Mont Godinne, UCL - (MGD) Service de neurologie, Fumery, Thibault, Baudar, Coline, Ossemann, Michel, and London, Frédéric
- Abstract
Corona Virus Disease 2019 (COVID-19) is a new illness caused by a novel coronavirus, severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2). With the increasing number of confirmed cases and the accumulating clinical data, a broad spectrum of neurological complications has been reported in the literature, including encephalopathy, stroke, Guillain-Barré syndrome, meningo-encephalitis, acute necrotizing hemorrhagic encephalopathy, and inflammatory central nervous system syndromes. Here, we describe the case of a 38-year-old woman presenting with longitudinally extensive transverse myelitis, revealed by bilateral lower limb weakness, decreased sensation below the Th4 level and urinary retention, and occuring 15 days after she had been diagnosed with COVID-19.
- Published
- 2021
5. An international pilot study of an internet-based platform to facilitate clinical research in epilepsy: The EpiNet project
- Author
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Bergin, Peter, Sadleir, Lynette, Legros, Benjamin, Mogal, Zarine, Tripathi, Manjari, Dang, Nitika, Beretta, Simone, Zanchi, Clara, Burneo, Jorge, Borkowski, Thomas, Cho, Yang Je, Ossemann, Michel, Striano, Pasquale, Srivastava, Kavita, Tan, Hui Jan, Wanigasinghe, Jithangi, and DʼSouza, Wendyl
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- 2012
- Full Text
- View/download PDF
6. Effect of tDCS with an extracephalic reference electrode on cardio-respiratory and autonomic functions
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Jamart Jacques, Vandermeeren Yves, and Ossemann Michel
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Neurosciences. Biological psychiatry. Neuropsychiatry ,RC321-571 ,Neurophysiology and neuropsychology ,QP351-495 - Abstract
Abstract Background Transcranial direct current stimulation (tDCS) is used in human physiological studies and for therapeutic trials in patients with abnormalities of cortical excitability. Its safety profile places tDCS in the pole-position for translating in real-world therapeutic application. However, an episode of transient respiratory depression in a subject receiving tDCS with an extracephalic electrode led to the suggestion that such an electrode montage could modulate the brainstem autonomic centres. We investigated whether tDCS applied over the midline frontal cortex in 30 healthy volunteers (sham n = 10, cathodal n = 10, anodal n = 10) with an extracephalic reference electrode would modulate brainstem activity as reflected by the monitoring and stringent analysis of vital parameters: heart rate (variability), respiratory rate, blood pressure and sympatho-vagal balance. We reasoned that this study could lead to two opposite but equally interesting outcomes: 1) If tDCS with an extracephalic electrode modulated vital parameters, it could be used as a new tool to explore the autonomic nervous system and, even, to modulate its activity for therapeutic purposes. 2) On the opposite, if applying tDCS with an extracephalic electrode had no effect, it could thus be used safely in healthy human subjects. This outcome would significantly impact the field of non-invasive brain stimulation with tDCS. Indeed, on the one hand, using an extracephalic electrode as a genuine neutral reference (as opposed to the classical "bi-cephalic" tDCS montages which deliver bi-polar stimulation of the brain) would help to comfort the conclusions of several modern studies regarding the spatial location and polarity of tDCS. On the other hand, using an extracephalic reference electrode may impact differently on a given cortical target due to the change of direct current flow direction; this may enlarge the potential interventions with tDCS. Results Whereas the respiratory frequency decreased mildly over time and the blood pressure increased steadily, there was no differential impact of real (anodal or cathodal) versus sham tDCS. The heart rate remained stable during the monitoring period. The parameters reflecting the sympathovagal balance suggested a progressive shift over time favouring the sympathetic tone, again without differential impact of real versus sham tDCS. Conclusions Applying tDCS with an extracephalic reference electrode in healthy volunteers did not significantly modulate the activity of the brainstem autonomic centres. Therefore, using an extracephalic reference electrode for tDCS appears safe in healthy volunteers, at least under similar experimental conditions.
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- 2010
- Full Text
- View/download PDF
7. Mobius syndrome and obsessive compulsive disorder: a case report.
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UCL - SSS/IREC/MONT - Pôle Mont Godinne, UCL - SSS/IRSS - Institut de recherche santé et société, UCL - (MGD) Service de médecine psychosomatique, UCL - (MGD) Service de neurologie, UCL - SSS/IONS - Institute of NeuroScience, UCL - SSS/IONS/NEUR - Clinical Neuroscience, Jacques, Denis, Ossemann, Michel, Timmermans, Jean Marc, Zdanowicz, Nicolas, Dubois, Thomas, UCL - SSS/IREC/MONT - Pôle Mont Godinne, UCL - SSS/IRSS - Institut de recherche santé et société, UCL - (MGD) Service de médecine psychosomatique, UCL - (MGD) Service de neurologie, UCL - SSS/IONS - Institute of NeuroScience, UCL - SSS/IONS/NEUR - Clinical Neuroscience, Jacques, Denis, Ossemann, Michel, Timmermans, Jean Marc, Zdanowicz, Nicolas, and Dubois, Thomas
- Abstract
BACKGROUND: Mobius syndrome is characterized by a bilateral congenital paralysis of the facial and abducens nerves which leaves the subject with an expressionless "mask-like" face. SUBJECTS AND METHODS: Based on a literature review and a case discussion of an adult patient with Mobius syndrome and obsessive-compulsive disorder, initially undiagnosed and confused with a psychotic disorder, we will discuss the influence of Mobius syndrome in psychiatric evaluations. RESULTS: The lack of facial expressiveness and non-verbal emotional interactions may influence psychiatric evaluations and result in misdiagnosis and the inappropriate prescribing of antipsychotics. In the case analysis, we also observed other associated malformations such as renal atrophy, a bicuspid aortic valve and mitral valve prolapse. CONCLUSION: We feel that educating the patient about the communicative consequences of impaired facial expressions and facial interactions is a necessary prerequisite for any psychiatric or psychological evaluation in subjects with Mobius syndrome. We also recommend using caution when prescribing antipsychotics in patients with Mobius syndrome given the motor side effects secondary to a potentially pre-existing hypotonia.
- Published
- 2019
8. MOBIUS SYNDROME AND OBSESSIVE COMPULSIVE DISORDER: A CASE REPORT
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Jacques, Denis, Ossemann, Michel, Timmermans, Jean-Marc, Zdanowicz, Nicolas, Dubois, Thomas, Jacques, Denis, Ossemann, Michel, Timmermans, Jean-Marc, Zdanowicz, Nicolas, and Dubois, Thomas
- Abstract
Background: Mobius syndrome is characterized by a bilateral congenital paralysis of the facial and abducens nerves which leaves the subject with an expressionless "mask-like" face. Subjects and methods: Based on a literature review and a case discussion of an adult patient with Mobius syndrome and obsessive-compulsive disorder, initially undiagnosed and confused with a psychotic disorder, we will discuss the influence of Mobius syndrome in psychiatric evaluations. Results: The lack of facial expressiveness and non-verbal emotional interactions may influence psychiatric evaluations and result in misdiagnosis and the inappropriate prescribing of antipsychotics. In the case analysis, we also observed other associated malformations such as renal atrophy, a bicuspid aortic valve and mitral valve prolapse. Conclusion: We feel that educating the patient about the communicative consequences of impaired facial expressions and facial interactions is a necessary prerequisite for any psychiatric or psychological evaluation in subjects with Mobius syndrome. We also recommend using caution when prescribing antipsychotics in patients with Mobius syndrome given the motor side effects secondary to a potentially pre-existing hypotonia.
- Published
- 2019
9. Stroke Triggered by an Asthma Attack
- Author
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Laloux, Patrice, Ossemann, Michel, and Marchandise, Baudouin
- Published
- 1993
10. Do neurologists around the world agree when diagnosing epilepsy? - Results of an international EpiNet study.
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UCL - SSS/IREC/MONT - Pôle Mont Godinne, UCL - (MGD) Service de neurologie, Bergin, Peter S, Beghi, Ettore, Sadleir, Lynette G, Tripathi, Manjari, Richardson, Mark P, Bianchi, Elisa, D'Souza, Wendyl J, EpiNet Study Group, Ossemann, Michel, UCL - SSS/IREC/MONT - Pôle Mont Godinne, UCL - (MGD) Service de neurologie, Bergin, Peter S, Beghi, Ettore, Sadleir, Lynette G, Tripathi, Manjari, Richardson, Mark P, Bianchi, Elisa, D'Souza, Wendyl J, EpiNet Study Group, and Ossemann, Michel
- Abstract
Previous studies have shown moderate agreement between physicians when diagnosing epilepsy, but have included small numbers. The EpiNet study group was established to undertake multicentre clinical trials in epilepsy. Before commencing trials, we wanted to determine levels of agreement between physicians from different countries and different health systems when diagnosing epilepsy, specific seizure types and etiologies. 30 Case scenarios describing six children and 24 adults with paroxysmal events (21 epileptic seizures, nine non-epileptic attacks) were presented to physicians with an interest in epilepsy. Physicians were asked how likely was a diagnosis of epilepsy; if seizures were generalised or focal; and the likely etiology. For 23 cases, clinical information was presented in Step 1, and investigations in Step 2. 189 Participants from 36 countries completed the 30 cases. Levels of agreement were determined for 154 participants who provided details regarding their clinical experience. There was substantial agreement for diagnosis of epilepsy (kappa=0.61); agreement was fair to moderate for seizure type(s) (kappa=0.40) and etiology (kappa=0.41). For 23 cases with two steps, agreement increased from step 1 to step 2 for diagnosis of epilepsy (kappa 0.56-0.70), seizure type(s) (kappa 0.38-0.52), and etiology (kappa 0.38-0.47). Agreement was better for 53 epileptologists (diagnosis of epilepsy, kappa=0.66) than 56 neurologists with a special interest in epilepsy (kappa=0.58). Levels of agreement differed slightly between physicians practicing in different parts of the world, between child and adult neurologists, and according to one's experience with epilepsy. Although there is substantial agreement when epileptologists diagnose epilepsy, there is less agreement for diagnoses of seizure types and etiology. Further education of physicians regarding semiology of different seizure types is required. Differences in approach to diagnosis, both between physicians and bet
- Published
- 2018
11. Paroxysmal Kinesigenic Dyskinesia as the Presenting and Only Manifestation of Multiple Sclerosis after Eighteen Months of Follow-Up
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Baguma, Marius, primary and Ossemann, Michel, additional
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- 2017
- Full Text
- View/download PDF
12. Contrast-associated transient cortical blindness: three cases with MRI and electrophysiology findings.
- Author
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UCL - (MGD) Service de neurologie, UCL - SSS/IONS/NEUR - Clinical Neuroscience, UCL - SSS/IREC/MONT-Pôle Mont Godinne, Baguma, Marius, Younan, Nadia, London, Frédéric, Ossemann, Michel, Vandermeeren, Yves, UCL - (MGD) Service de neurologie, UCL - SSS/IONS/NEUR - Clinical Neuroscience, UCL - SSS/IREC/MONT-Pôle Mont Godinne, Baguma, Marius, Younan, Nadia, London, Frédéric, Ossemann, Michel, and Vandermeeren, Yves
- Abstract
Transient cortical blindness (TCB) is a rare but striking complication following contrast agent injection. TCB might be secondary to a direct toxicity of the contrast agent, leading to an osmotic disruption of the blood-brain barrier (BBB), with a preferential involvement of the posterior circulation and occipital cortex. We report a series of three patients with contrast medium-associated TCB (intra-arterial injection of non-ionic contrast agent during diagnostic cerebral angiography for two of them and coronary angioplasty for the other one). In two patients, the magnetic resonance imaging (MRI) was unremarkable; in the other patient, typical MRI findings were observed, with FLAIR hyperintensities in the right occipital cortex and decreased apparent diffusions coefficient (ADC). Interestingly, this patient also presented posterior rhythmic epileptiform activities on electroencephalogram during the first 36 h. Visual evoked potentials (VEPs) showed normal retinal potential, but a massive destructuration of the later potentials of the cortical origin. To our knowledge, this is the first time that VEPs acquired during TCB are reported. We discuss these findings with respect to the pathophysiology of TCB.
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- 2017
13. Neuroprognostication after adult cardiac arrest treated with targeted temperature management: task force for Belgian recommendations.
- Author
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UCL - SSS/IREC/MONT-Pôle Mont Godinne, UCL - (MGD) Service de neurologie, UCL - SSS/IONS/NEUR - Clinical Neuroscience, Taccone, Fabio Silvio, Baar, Ingrid, De Deyne, Cathy, Druwe, Patrick, Legros, Benjamin, Meyfroidt, Geert, Ossemann, Michel, Gaspard, Nicolas, UCL - SSS/IREC/MONT-Pôle Mont Godinne, UCL - (MGD) Service de neurologie, UCL - SSS/IONS/NEUR - Clinical Neuroscience, Taccone, Fabio Silvio, Baar, Ingrid, De Deyne, Cathy, Druwe, Patrick, Legros, Benjamin, Meyfroidt, Geert, Ossemann, Michel, and Gaspard, Nicolas
- Abstract
The prognosis of patients who are admitted to the hospital after cardiac arrest often relies on neurological examination, which could be significantly influenced by the use of sedative drugs or the implementation of targeted temperature management. The need for early and accurate prognostication is crucial as up to 15-20% of patients could be considered as having a poor outcome and may undergo withdrawal of life-sustaining therapies while a complete neurological recovery is still possible. As current practice in Belgium is still based on a very early assessment of neurological function in these patients, the Belgian Society of Intensive Care Medicine created a multidisciplinary Task Force to provide an optimal approach for monitoring and refine prognosis of CA survivors. This Task Force underlined the importance to use a multimodal approach using several additional tools (e.g., electrophysiological tests, neuroimaging, biomarkers) and to refer cases with uncertain prognosis to specialized centers to better evaluate the extent of brain injury in these patients.
- Published
- 2017
14. Paroxysmal Kinesigenic Dyskinesia as the Presenting and Only Manifestation of Multiple Sclerosis after Eighteen Months of Follow-Up.
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UCL - SSS/IREC/MONT - Pôle Mont Godinne, UCL - (MGD) Service de neurologie, UCL - SSS/IONS/NEUR - Clinical Neuroscience, Baguma, Marius, Ossemann, Michel, UCL - SSS/IREC/MONT - Pôle Mont Godinne, UCL - (MGD) Service de neurologie, UCL - SSS/IONS/NEUR - Clinical Neuroscience, Baguma, Marius, and Ossemann, Michel
- Abstract
Other than tremor, movement disorders are uncommon in multiple sclerosis. Among these uncommon clinical manifestations, paroxysmal kinesigenic dyskinesia is the most frequently reported. It is characterized by episodic attacks of involuntary movements that are induced by repetitive or sudden movements, startling noise or hyperventilation. The diagnosis is essentially clinical and based on a good observation of the attacks. It is very easy to misdiagnose it. We describe the case of a young female patient who presented paroxysmal kinesigenic dyskinesia as the first and only clinical manifestation of multiple sclerosis, with no recurrence of attacks nor any other neurologic symptom after eighteen months of follow-up.
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- 2017
15. EpiNet as a way of involving more physicians and patients in epilepsy research: Validation study and accreditation process.
- Author
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UCL - SSS/IONS/NEUR - Clinical Neuroscience, UCL - (MGD) Service de neurologie, Bergin, Peter S, Beghi, Ettore, Sadleir, Lynette G, Brockington, Alice, Tripathi, Manjari, Richardson, Mark P, Bianchi, Elisa, Srivastava, Kavita, Jayabal, Jayaganth, Legros, Benjamin, Ossemann, Michel, McGrath, Nicole, Verrotti, Alberto, Tan, Hui Jan, Beretta, Simone, Frith, Richard, Iniesta, Ivan, Whitham, Emma, Wanigasinghe, Jithangi, Ezeala-Adikaibe, Birinus, Striano, Pasquale, Rosemergy, Ian, Walker, Elizabeth B, Alkhidze, Maia, Rodriguez-Leyva, Ildefonso, Ramírez González, Jose Alfredo, D'Souza, Wendyl J, EpiNet Study Group, UCL - SSS/IONS/NEUR - Clinical Neuroscience, UCL - (MGD) Service de neurologie, Bergin, Peter S, Beghi, Ettore, Sadleir, Lynette G, Brockington, Alice, Tripathi, Manjari, Richardson, Mark P, Bianchi, Elisa, Srivastava, Kavita, Jayabal, Jayaganth, Legros, Benjamin, Ossemann, Michel, McGrath, Nicole, Verrotti, Alberto, Tan, Hui Jan, Beretta, Simone, Frith, Richard, Iniesta, Ivan, Whitham, Emma, Wanigasinghe, Jithangi, Ezeala-Adikaibe, Birinus, Striano, Pasquale, Rosemergy, Ian, Walker, Elizabeth B, Alkhidze, Maia, Rodriguez-Leyva, Ildefonso, Ramírez González, Jose Alfredo, D'Souza, Wendyl J, and EpiNet Study Group
- Abstract
EpiNet was established to encourage epilepsy research. EpiNet is used for multicenter cohort studies and investigator-led trials. Physicians must be accredited to recruit patients into trials. Here, we describe the accreditation process for the EpiNet-First trials. Physicians with an interest in epilepsy were invited to assess 30 case scenarios to determine the following: whether patients have epilepsy; the nature of the seizures (generalized, focal); and the etiology. Information was presented in two steps for 23 cases. The EpiNet steering committee determined that 21 cases had epilepsy. The steering committee determined by consensus which responses were acceptable for each case. We chose a subset of 18 cases to accredit investigators for the EpiNet-First trials. We initially focused on 12 cases; to be accredited, investigators could not diagnose epilepsy in any case that the steering committee determined did not have epilepsy. If investigators were not accredited after assessing 12 cases, 6 further cases were considered. When assessing the 18 cases, investigators could be accredited if they diagnosed one of six nonepilepsy patients as having possible epilepsy but could make no other false-positive errors and could make only one error regarding seizure classification. Between December 2013 and December 2014, 189 physicians assessed the 30 cases. Agreement with the steering committee regarding the diagnosis at step 1 ranged from 47% to 100%, and improved when information regarding tests was provided at step 2. One hundred five of the 189 physicians (55%) were accredited for the EpiNet-First trials. The kappa value for diagnosis of epilepsy across all 30 cases for accredited physicians was 0.70. We have established criteria for accrediting physicians using EpiNet. New investigators can be accredited by assessing 18 case scenarios. We encourage physicians with an interest in epilepsy to become EpiNet-accredited and to participate in these investigator-led clinical tri
- Published
- 2017
16. Neuroprognostication after adult cardiac arrest treated with targeted temperature management: task force for Belgian recommendations
- Author
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Taccone, Fabio, Baar, Ingrid, De Deyne, Cathy, Druwé, Patrick, Legros, Benjamin, Meyfroidt, Geert, Ossemann, Michel, Gaspard, Nicolas, Taccone, Fabio, Baar, Ingrid, De Deyne, Cathy, Druwé, Patrick, Legros, Benjamin, Meyfroidt, Geert, Ossemann, Michel, and Gaspard, Nicolas
- Abstract
The prognosis of patients who are admitted to the hospital after cardiac arrest often relies on neurological examination, which could be significantly influenced by the use of sedative drugs or the implementation of targeted temperature management. The need for early and accurate prognostication is crucial as up to 15–20% of patients could be considered as having a poor outcome and may undergo withdrawal of life-sustaining therapies while a complete neurological recovery is still possible. As current practice in Belgium is still based on a very early assessment of neurological function in these patients, the Belgian Society of Intensive Care Medicine created a multidisciplinary Task Force to provide an optimal approach for monitoring and refine prognosis of CA survivors. This Task Force underlined the importance to use a multimodal approach using several additional tools (e.g. electrophysiological tests, neuroimaging, biomarkers) and to refer cases with uncertain prognosis to specialized centers to better evaluate the extent of brain injury in these patients., SCOPUS: ar.j, SCOPUS: re.j, info:eu-repo/semantics/published
- Published
- 2017
17. The epileptic syndromes with continuous spikes and waves during slow sleep: definition and management guidelines
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Van Bogaert, P, Aeby, A, De Borchgrave, V, De Cocq, C, Deprez, M, De Tiège, X, de Tourtchaninoff, M, Dubru, J M, Foulon, M, Ghariani, S, Grisar, T, Legros, B, Ossemann, Michel, Tugendhaft, P, van Rijckevorsel, K, Verheulpen, D, Groupe de travail des centres francophones de référence de l'epilepsie réfractaire, UCL - SSS/IREC/MONT - Pôle Mont Godinne, and UCL - (MGD) Service de neurologie
- Subjects
Epilepsy ,Practice Guidelines as Topic -- standards ,Epilepsy -- physiopathology ,Sleep -- physiology ,Practice Guidelines as Topic ,Action Potentials -- physiology ,Action Potentials ,Humans ,Syndrome ,Sciences bio-médicales et agricoles ,Sleep ,Epilepsy -- therapy - Abstract
The authors propose to define the epileptic syndromes with continuous spikes and waves during slow sleep (CSWS) as a cognitive or behavioral impairment acquired during childhood, associated with a strong activation of the interictal epileptiform discharges during NREM sleep--whatever focal or generalized--and not related to another factor than the presence of CSWS. The type of syndrome will be defined according to the neurological and neuropsychological deficit. These syndromes have to be classified among the localization-related epileptic syndromes. Some cases are idiopathic and others are symptomatic. Guidelines for work-up and treatment are proposed., Journal Article, Review, SCOPUS: ar.j, info:eu-repo/semantics/published
- Published
- 2006
18. Guidelines for recognition and treatment of the psychoses associated with epilepsy
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Tugendhaft, P, Ansseau, M, de Borchgrave, V, Delvaux, V, de Tourtchaninoff, M, Dubru, J M, Floris, M, Foulon, M, Grisar, T, Hmaimess, G, Legros, B, Mahieu, B, Ossemann, Michel, Sadzot, B, van Ruckevorsel, K, Verheulpen, D, UCL - SSS/IREC/MONT - Pôle Mont Godinne, and UCL - (MGD) Service de neurologie
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Epilepsy ,Psychotic Disorders ,mental disorders ,Practice Guidelines as Topic ,Humans ,Antipsychotic Agents - Abstract
Epilepsy and psychiatric diseases are frequent comorbidities. Psychoses in patients with epilepsy have special physiopathology and several clinical presentations and prognoses. Their treatments are also specific, according to the specific diagnosis. This paper represents the summary of a consensus meeting held in November 2003 by a Belgian French-speaking group of neurologists, neuropediatricians and psychiatrists and proposes guidelines for the recognition and treatment of those entities.
- Published
- 2005
19. Therapeutic issues in women with epilepsy
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Legros, B, Bottin, P, de Borchgrave, V, Delcourt, C, de Tourtchaninoff, M, Dubru, J M, Foulon, M, Ghariani, S, Grisar, T, Hotermans, C, Ossemann, Michel, Sadzot, B, Tugendhaft, P, Van Bogaert, P, van Rijckevorsel, K, Verheulpen, D, UCL - SSS/IREC/MONT - Pôle Mont Godinne, and UCL - (MGD) Service de neurologie
- Subjects
Breast Feeding ,Epilepsy ,Fertility ,Pregnancy ,Humans ,Anticonvulsants ,Female ,Menopause - Abstract
Approximately 20% of people with epilepsy are of childbearing potential and about 3 to 5 births per thousand will be to women with epilepsy. Both epilepsy and antiepileptic drugs can cause specific problems in women and embryos (less than 8 weeks of gestational age) or foetuses (more than 8 weeks of gestational age). The aim of this paper is to discuss therapeutic issues for the management of women with epilepsy: initiation of antiepileptic therapy, contraception, pregnancy, breast feeding and menopause. Some fertility issues are also discussed.
- Published
- 2003
20. Therapeutic strategies in the choice of antiepileptic drugs
- Author
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de Borchgrave, V, Delvaux, V, de Tourchaninoff, M, Dubru, J M, Ghariani, S, Grisar, Th, Legros, B, Ossemann, Michel, Sadzot, B, Tugendhaft, P, Van Bogaert, P, van Rijckevorsel, K, Groupe de travail des Centres Francophones de Reference de l'Epilepsie Refractaire, UCL - SSS/IREC/MONT - Pôle Mont Godinne, and UCL - (MGD) Service de neurologie
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Epilepsy ,Treatment Outcome ,Decision Trees ,Drug Resistance ,Infant, Newborn ,Humans ,Anticonvulsants ,Drug Interactions ,Drug Therapy, Combination ,Drug Tolerance ,Child - Abstract
The choice of treatment of newly diagnosed epilepsy involves many factors such as age, sex, life style, general health and concomitant medication. The seizure type, syndrome, and the pharmacology, efficacy and safety of the antiepileptic drugs (AEDs) should also be considered. Some of the new AEDs appear to provide at least equivalent efficacy with better tolerability. Some of these drugs have the potential to become drugs of first choice in newly diagnosed epilepsy. At the present time, we also must consider the criteria of reimbursement of these drugs. In this paper, we try to describe common and practical strategies to start a treatment of newly diagnosed epilepsy.
- Published
- 2002
21. Postoperative Analgesic Effect of Transcranial Direct Current Stimulation in Lumbar Spine Surgery. A Randomized Control Trial
- Author
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UCL - SSS/IONS/NEUR - Clinical Neuroscience, UCL - (MGD) Service de neurologie, UCL - (MGD) Service d'anesthésiologie, UCL - (MGD) Unité de support scientifique, UCL - SSS/IREC/MONT - Pôle Mont Godinne, UCL - SSS/IREC/MEDA - Pôle de médecine aiguë, Dubois, Philippe E, Ossemann, Michel, de FAYS, Katalin, De Bue, Pascale, Gourdin, Maximilien, Jamart, Jacques, Vandermeeren, Yves, UCL - SSS/IONS/NEUR - Clinical Neuroscience, UCL - (MGD) Service de neurologie, UCL - (MGD) Service d'anesthésiologie, UCL - (MGD) Unité de support scientifique, UCL - SSS/IREC/MONT - Pôle Mont Godinne, UCL - SSS/IREC/MEDA - Pôle de médecine aiguë, Dubois, Philippe E, Ossemann, Michel, de FAYS, Katalin, De Bue, Pascale, Gourdin, Maximilien, Jamart, Jacques, and Vandermeeren, Yves
- Abstract
Background: Ultimately, the experience of pain derives from changes in brain excitability. Therefore, modulating the excitability of cortical areas involved in pain processing may become an attractive option in the context of multimodal analgesia during the postoperative period. Repetitive transcranial magnetic stimulation (rTMS) can reduce morphine consumption during the postoperative period after gastric bypass surgery. We tested the potential of another method of noninvasive brain stimulation, transcranial direct current stimulation (tDCS), to reduce morphine consumption or pain perception during the postoperative period.
- Published
- 2013
22. Transcranial doppler assessment of cerebral perfusion in critically ill septic patients: a pilot study.
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UCL - (MGD) Services des soins intensifs, UCL - (MGD) Service de neurologie, UCL - SSS/IREC/MEDA - Pôle de médecine aiguë, UCL - SSS/IREC/MONT - Pôle Mont Godinne, UCL - SSS/IONS/NEUR - Clinical Neuroscience, Pierrakos, Charalampos, Antoine, Aurélie, Velissaris, Dimitrios, Michaux, Isabelle, Bulpa, Pierre, Evrard, Patrick, Ossemann, Michel, Dive, Alain-Michel, UCL - (MGD) Services des soins intensifs, UCL - (MGD) Service de neurologie, UCL - SSS/IREC/MEDA - Pôle de médecine aiguë, UCL - SSS/IREC/MONT - Pôle Mont Godinne, UCL - SSS/IONS/NEUR - Clinical Neuroscience, Pierrakos, Charalampos, Antoine, Aurélie, Velissaris, Dimitrios, Michaux, Isabelle, Bulpa, Pierre, Evrard, Patrick, Ossemann, Michel, and Dive, Alain-Michel
- Abstract
Our results suggest cerebral vasoconstriction in septic compared to non-septic patients. TCD is an efficient and feasible exam to evaluate changes in cerebral perfusion during sepsis.
- Published
- 2013
23. First line management of prolonged convulsive seizures in children and adults: good practice points.
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UCL - (SLuc) Service de neurologie pédiatrique, UCL - SSS/IONS/NEUR - Clinical Neuroscience, UCL - (MGD) Service de neurologie, De Waele, Liesbeth, Boon, Paul, Ceulemans, Berten, Dan, Bernard, Jansen, Anna, Legros, Benjamin, Leroy, Patricia, Delmelle, Francoise, Ossemann, Michel, De Raedt, Sylvie, Smets, Katrien, Van De Voorde, Patrick, Verhelst, Helene, Lagae, Lieven, UCL - (SLuc) Service de neurologie pédiatrique, UCL - SSS/IONS/NEUR - Clinical Neuroscience, UCL - (MGD) Service de neurologie, De Waele, Liesbeth, Boon, Paul, Ceulemans, Berten, Dan, Bernard, Jansen, Anna, Legros, Benjamin, Leroy, Patricia, Delmelle, Francoise, Ossemann, Michel, De Raedt, Sylvie, Smets, Katrien, Van De Voorde, Patrick, Verhelst, Helene, and Lagae, Lieven
- Abstract
Over the past decades, it has become clear that the most efficient way to prevent status epilepticus is to stop the seizure as fast as possible, and early treatment of prolonged convulsive seizures has become an integral part of the overall treatment strategy in epilepsy. Benzodiazepines are the first choice drugs to be used as emergency medication. This treatment in the early phases of a seizure often implies a 'pre-medical' setting before intervention of medically trained persons. In this paper, we propose "good practice points" for first line management of prolonged convulsive seizures in children and adults in a 'pre-medical' setting.
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- 2013
24. First line management of prolonged convulsive seizures in children and adults: Good practice points
- Author
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De Waele, Liesbeth, Lagae, Lieven, Boon, Paul, Ceulemans, Berten, Smets, Katrien, Dan, Bernard, Jansen, Anna C M A.C., Legros, Benjamin, Leroy, Patricia, Delmelle, Francoise, Ossemann, Michel, De Raedt, Sylvie, Van De Voorde, Patrick, Verhelst, Hélène, De Waele, Liesbeth, Lagae, Lieven, Boon, Paul, Ceulemans, Berten, Smets, Katrien, Dan, Bernard, Jansen, Anna C M A.C., Legros, Benjamin, Leroy, Patricia, Delmelle, Francoise, Ossemann, Michel, De Raedt, Sylvie, Van De Voorde, Patrick, and Verhelst, Hélène
- Abstract
Over the past decades, it has become clear that the most efficient way to prevent status epilepticus is to stop the seizure as fast as possible, and early treatment of prolonged convulsive seizures has become an integral part of the overall treatment strategy in epilepsy. Benzodiazepines are the first choice drugs to be used as emergency medication. This treatment in the early phases of a seizure often implies a 'pre-medical' setting before intervention of medically trained persons. In this paper, we propose "good practice points" for first line management of prolonged convulsive seizures in children and adults in a 'pre-medical' setting. © 2013 Belgian Neurological Society., SCOPUS: ar.j, info:eu-repo/semantics/published
- Published
- 2013
25. Unexplained syncopes: What place is there for the liaison psychiatry? analysis of the first year of the interdisciplinary centre of unexplained faintness and syncopes
- Author
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UCL - SSS/IREC/CARD - Pôle de recherche cardiovasculaire, UCL - SSS/IREC/MONT - Pôle Mont Godinne, UCL - (MGD) Service de cardiologie, UCL - (MGD) Service de neurologie, UCL - (MGD) Service d'oto-rhino-laryngologie, UCL - (MGD) Service de médecine psychosomatique, UCL - SSS/IRSS - Institut de recherche santé et société, UCL - SSS/IONS/NEUR - Clinical Neuroscience, Jacques, Denis, Blommaert, Dominique, Gilain, Chantal, Zdanowicz, Nicolas, Ossemann, Michel, UCL - SSS/IREC/CARD - Pôle de recherche cardiovasculaire, UCL - SSS/IREC/MONT - Pôle Mont Godinne, UCL - (MGD) Service de cardiologie, UCL - (MGD) Service de neurologie, UCL - (MGD) Service d'oto-rhino-laryngologie, UCL - (MGD) Service de médecine psychosomatique, UCL - SSS/IRSS - Institut de recherche santé et société, UCL - SSS/IONS/NEUR - Clinical Neuroscience, Jacques, Denis, Blommaert, Dominique, Gilain, Chantal, Zdanowicz, Nicolas, and Ossemann, Michel
- Abstract
Introduction: The diagnostic process of syncopes remains an important and complex issue. In spite of everything, it is estimated that 20 to 30% of syncopes remain unexplained. The diagnosis of psychogenic syncope is estimated at 5.5% to 14% of syncopes. A systematic psychiatric evaluation of unexplained syncopes would be strongly recommended. We present here the original care by the "Centre Interdisciplinaire des Malaises Inexpliqués et des Syncopes (Interdisciplinary Centre of Unexplained Faintness and Syncopes.)" set up by the neurology and cardiology departments associated with the ENT department. We describe the place liaison psychiatry has been able to define and its field of action. Subject and methods: After a year of operation, and on the basis of structured interviews with the "Mini International Neuropsychiatric Interview" and on a review of records, we assessed the recruitment in terms of psychiatric monitoring as well as the associated psychiatric diagnoses in patients who consulted for an unexplained syncope. Results: Of the 91 patients who have consulted the Interdisciplinary Centre of Unexplained Faintness and Syncopes in 2009, 24% have been directed towards a psychiatric evaluation. Among these, 68% suffered from an anxiety disorder, 27% from a major depressive disorder and 22% from a substance-related disorder. Discussion: We assess the interesting conditions that the Interdisciplinary Centre of Unexplained Faintness and Syncopes proposes for a liaison psychiatry activity. We note the interest in easier access to psychiatric care for a group that would not have spontaneously approached the Centre. Conclusion: Other measures of quality of care indices are still to be developed. © Medicinska naklada - Zagreb, Croatia.
- Published
- 2012
26. Brain controls the heart: A case of ictal asystole
- Author
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UCL - SSS/IREC/CARD - Pôle de recherche cardiovasculaire, UCL - (MGD) Service de cardiologie, UCL - (MGD) Service de neurologie, UCL - SSS/IONS/NEUR - Clinical Neuroscience, Sprimont, P., Ossemann, Michel, Blommaert, Dominique, UCL - SSS/IREC/CARD - Pôle de recherche cardiovasculaire, UCL - (MGD) Service de cardiologie, UCL - (MGD) Service de neurologie, UCL - SSS/IONS/NEUR - Clinical Neuroscience, Sprimont, P., Ossemann, Michel, and Blommaert, Dominique
- Abstract
Ictal asystole is a rare complication of epileptic seizures and is frequently unrecognized by non-neurologists. We describe a case of ictal asystole as first clinical manifestation of unknown temporal lobe epilepsy and we discuss epidemiologic, pathophysiologic and therapeutic features.
- Published
- 2012
27. Recommendations for the treatment of epilepsy in adult patients in general practice in Belgium: An update
- Author
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UCL - (MGD) Service de neurologie, UCL - SSS/IONS/NEUR - Clinical Neuroscience, UCL - (SLuc) Service de neurologie, Boon, Paul, Engelborghs, Sebastiaan, Hauman, Henri, Jansen, An, Lagae, Lieven, Legros, Benjamin, Ossemann, Michel, Sadzot, Bernard, Smets, Katrien, Urbain, Etienne, van Rijckevorsel, Kenou, UCL - (MGD) Service de neurologie, UCL - SSS/IONS/NEUR - Clinical Neuroscience, UCL - (SLuc) Service de neurologie, Boon, Paul, Engelborghs, Sebastiaan, Hauman, Henri, Jansen, An, Lagae, Lieven, Legros, Benjamin, Ossemann, Michel, Sadzot, Bernard, Smets, Katrien, Urbain, Etienne, and van Rijckevorsel, Kenou
- Abstract
In 2008, a group of Belgian epilepsy experts published recommendations for antiepileptic drug (AED) treatment of epilepsies in adults and children. Selection of compounds was based on the registration and reimbursement status in Belgium, the level of evidence for efficacy, common daily practice and the personal views and experiences of the authors. In November 2011 the validity of these recommendations was reviewed by the same group of Belgian epilepsy experts who contributed to the preparation of the original paper. The recommendations made in 2008 for initial monotherapy in paediatric patients were still considered to be valid, except for the first choice treatment for childhood absence epilepsy. This update therefore focuses on the treatment recommendations for initial monotherapy and add-on treatment in adult patients. Several other relevant aspects of treatment with AEDs are addressed, including considerations for optimal combination of AEDs (rational polytherapy), pharmacokinetic properties, pharmacodynamic and pharmacokinetic interaction profile, adverse effects, comorbidity, treatment of elderly patients, AED treatment during pregnancy, and generic substitution of AEDs. © 2012 The Author(s).
- Published
- 2012
28. Development of an electronic decision tool to support appropriate treatment choice in adult patients with epilepsy - Epi-Scope ®
- Author
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Legros, Benjamin, Boon, Paul, Ceulemans, Berten, Coppens, Thomas, Geens, Karine, Hauman, Henri, Lagae, Lieven, Meurs, Alfred, Mol, Leon, Ossemann, Michel, Van Rijckevorsel, Kenou, Van Zandijcke, Michel, Vrielynck, Pascal, Wagemans, Daniëlla, Grisar, Thierry, Legros, Benjamin, Boon, Paul, Ceulemans, Berten, Coppens, Thomas, Geens, Karine, Hauman, Henri, Lagae, Lieven, Meurs, Alfred, Mol, Leon, Ossemann, Michel, Van Rijckevorsel, Kenou, Van Zandijcke, Michel, Vrielynck, Pascal, Wagemans, Daniëlla, and Grisar, Thierry
- Abstract
Background: Given the continuous knowledge progression and the growing number of available antiepileptic drugs (AEDs), making appropriate treatment choices for patients with epilepsy is increasingly difficult. While published guidelines help for separate clinical aspects, patients with a combination of specific characteristics may escape proper guidance. This study aimed to determine the appropriateness of AEDs for particular clinical variables and to offer treatment recommendations for adult patients with epilepsy in a user-friendly format for practicing neurologists. Methods: Using the RAND/UCLA Appropriateness Method, the appropriateness of AEDs as initial/second mono-therapy and combination therapy was assessed in relation to selected clinical variables by a Belgian panel of 13 experts in epilepsy. Panel recommendations for particular patient profiles were determined by the outcome of these separate ratings. Results: The appropriateness outcome of individual AEDs was not substantially different between first and second mono-therapy; valproate was considered appropriate for all types of generalised and partial seizures. The outcome for combination therapy was highly dependent on the type of AED and seizures. With respect to co-morbidities and co-treatments, levetiracetam and pregabalin proved to have the least contra-indications. For the elderly and with respect to factors related to the female reproductive system the appropriateness of AEDs showed a more diffuse pattern. Although caution was deemed necessary for some combinations, the AEDs were never considered inappropriate regarding their drug interaction profile. Conclusions: The Epi-Scope ® tool that displays appropriateness recommendations for highly specific, possibly complex cases, supports optimal treatment choices for adult patients with epilepsy in daily practice. © 2011 British Epilepsy Association. Published by Elsevier Ltd. All rights reserved., SCOPUS: ar.j, info:eu-repo/semantics/published
- Published
- 2012
29. Recommendations for the treatment of epilepsy in adult patients in general practice in Belgium: An update
- Author
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Boon, Paul, Engelborghs, Sebastiaan, Hauman, Henri, Jansen, An, Lagae, Lieven, Legros, Benjamin, Ossemann, Michel, Sadzot, Bernard, Smets, Katrien, Urbain, Etienne, Van Rijckevorsel, Kenou, Boon, Paul, Engelborghs, Sebastiaan, Hauman, Henri, Jansen, An, Lagae, Lieven, Legros, Benjamin, Ossemann, Michel, Sadzot, Bernard, Smets, Katrien, Urbain, Etienne, and Van Rijckevorsel, Kenou
- Abstract
In 2008, a group of Belgian epilepsy experts published recommendations for antiepileptic drug (AED) treatment of epilepsies in adults and children. Selection of compounds was based on the registration and reimbursement status in Belgium, the level of evidence for efficacy, common daily practice and the personal views and experiences of the authors. In November 2011 the validity of these recommendations was reviewed by the same group of Belgian epilepsy experts who contributed to the preparation of the original paper. The recommendations made in 2008 for initial monotherapy in paediatric patients were still considered to be valid, except for the first choice treatment for childhood absence epilepsy. This update therefore focuses on the treatment recommendations for initial monotherapy and add-on treatment in adult patients. Several other relevant aspects of treatment with AEDs are addressed, including considerations for optimal combination of AEDs (rational polytherapy), pharmacokinetic properties, pharmacodynamic and pharmacokinetic interaction profile, adverse effects, comorbidity, treatment of elderly patients, AED treatment during pregnancy, and generic substitution of AEDs. © 2012 The Author(s)., SCOPUS: re.j, info:eu-repo/semantics/published
- Published
- 2012
30. An international pilot study of an Internet-based platform to facilitate clinical research in epilepsy: the EpiNet project.
- Author
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UCL - SSS/IREC/MONT - Pôle Mont Godinne, UCL - (MGD) Service de neurologie, Bergin, Peter, Sadleir, Lynette, Legros, Benjamin, Mogal, Zarine, Tripathi, Manjari, Dang, Nitika, Beretta, Simone, Zanchi, Clara, Burneo, Jorge, Borkowski, Thomas, Cho, Yang Je, Ossemann, Michel, Striano, Pasquale, Srivastava, Kavita, Tan, Hui Jan, Wanigasinghe, Jithangi, D'Souza, Wendyl, EpiNet study group, UCL - SSS/IREC/MONT - Pôle Mont Godinne, UCL - (MGD) Service de neurologie, Bergin, Peter, Sadleir, Lynette, Legros, Benjamin, Mogal, Zarine, Tripathi, Manjari, Dang, Nitika, Beretta, Simone, Zanchi, Clara, Burneo, Jorge, Borkowski, Thomas, Cho, Yang Je, Ossemann, Michel, Striano, Pasquale, Srivastava, Kavita, Tan, Hui Jan, Wanigasinghe, Jithangi, D'Souza, Wendyl, and EpiNet study group
- Abstract
We created an epilepsy patient database that can be accessed via the Internet by neurologists from anywhere in the world. The database was designed to enroll and follow large cohorts of patients with specific epilepsy syndromes, and to facilitate recruitment of patients for investigator-initiated clinical trials. The EpiNet database records physician-derived information regarding seizure type and frequency, epilepsy syndrome, etiology, drug history, and investigations. It can be accessed from any country by approved investigators via a secure, password-protected Website. All data are encrypted. The database is for both research and clinical purposes. Investigators were invited to register any patient with epilepsy, but were particularly encouraged to register patients when uncertain of the optimal management. Participation required approval from investigators' ethics committees and institutional review boards, and all patients or their caregiver provided written informed consent. Patients were not enrolled in clinical trials in this pilot study. The international pilot study recruited patients from September 2010 to November 2011. Sixty-four investigators or research assistants from 25 centers in 13 countries registered 1,050 patients. Patients with a wide range of epilepsy syndromes and etiologies were registered. Patients' ages ranged from 2 weeks to 90 years. The Website was successfully used by doctors working in different health systems. The pilot study confirmed that this low-cost, collaborative approach to research has great potential. Large, multicenter cohort studies will commence in 2012, and randomized clinical trials are being planned. All epileptologists are invited to join this project.
- Published
- 2012
31. UNEXPLAINED SYNCOPES: WHAT PLACE IS THERE FOR THE LIAISON PSYCHIATRY? Analysis of the first year of the Interdisciplinary Centre of Unexplained Faintness and Syncopes
- Author
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Jacques, Denis, Blommaert, Dominique, Gilain, Chantal, Zdanowicz, Nicolas, Ossemann, Michel, Jacques, Denis, Blommaert, Dominique, Gilain, Chantal, Zdanowicz, Nicolas, and Ossemann, Michel
- Published
- 2012
32. Short- and long-lasting tinnitus relief induced by transcranial direct current stimulation
- Author
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UCL - (MGD) Service de neurologie, UCL - SSS/IREC/MONT - Pôle Mont Godinne, UCL - (MGD) Unité de support scientifique, UCL - (MGD) Service d'oto-rhino-laryngologie, UCL - SSS/IONS/NEUR - Clinical Neuroscience, Garin, Pierre, Gilain, Chantal, Van Damme, Jean-Philippe, de Fays, Katalin, Jamart, Jacques, Ossemann, Michel, Vandermeeren, Yves, UCL - (MGD) Service de neurologie, UCL - SSS/IREC/MONT - Pôle Mont Godinne, UCL - (MGD) Unité de support scientifique, UCL - (MGD) Service d'oto-rhino-laryngologie, UCL - SSS/IONS/NEUR - Clinical Neuroscience, Garin, Pierre, Gilain, Chantal, Van Damme, Jean-Philippe, de Fays, Katalin, Jamart, Jacques, Ossemann, Michel, and Vandermeeren, Yves
- Abstract
A significant proportion of the population suffers from tinnitus, a bothersome auditory phantom perception that can severely alter the quality of life. Numerous experimental studies suggests that a maladaptive plasticity of the auditory and limbic cortical areas may underlie tinnitus. Accordingly, repetitive transcranial magnetic stimulation (rTMS) has been repeatedly used with success to reduce tinnitus intensity. The potential of transcranial direct current stimulation (tDCS), another promising method of noninvasive brain stimulation, to relieve tinnitus has not been explored systematically. In a double-blind, placebo-controlled and balanced order design, 20 patients suffering from chronic untreatable tinnitus were submitted to 20 minutes of 1 mA anodal, cathodal and sham tDCS targeting the left temporoparietal area. The primary outcome measure was a change in tinnitus intensity or discomfort assessed with a Visual Analogic Scale (VAS) change-scale immediately after tDCS and 1 hour later. Compared to sham tDCS, anodal tDCS significantly reduced tinnitus intensity immediately after stimulation; whereas cathodal tDCS failed to do so. The variances of the tinnitus intensity and discomfort VAS change-scales increased dramatically after anodal and cathodal tDCS, whereas they remained virtually unchanged after sham tDCS. Moreover, several patients unexpectedly reported longer-lasting effects (at least several days) such as tinnitus improvement, worsening, or changes in tinnitus features, more frequently after real than sham tDCS. Anodal tDCS is a promising therapeutic tool for modulating tinnitus perception. Moreover, both anodal and cathodal tDCS seem able to alter tinnitus perception and could, thus, be used to trigger plastic changes.
- Published
- 2011
33. Postoperative analgesic effect of anodal tDCS
- Author
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UCL - SSS/IONS/NEUR - Clinical Neuroscience, UCL - (MGD) Service de neurologie, UCL - (MGD) Service d'anesthésiologie, UCL - (MGD) Unité de support scientifique, UCL - SSS/IREC/MEDA - Pôle de médecine aiguë, UCL - SSS/IREC/MONT - Pôle Mont Godinne, Soete, Olivier, Dubois, Philippe E, Jamart, Jacques, Ossemann, Michel, Gourdin, Maximilien, Vandermeeren, Yves, UCL - SSS/IONS/NEUR - Clinical Neuroscience, UCL - (MGD) Service de neurologie, UCL - (MGD) Service d'anesthésiologie, UCL - (MGD) Unité de support scientifique, UCL - SSS/IREC/MEDA - Pôle de médecine aiguë, UCL - SSS/IREC/MONT - Pôle Mont Godinne, Soete, Olivier, Dubois, Philippe E, Jamart, Jacques, Ossemann, Michel, Gourdin, Maximilien, and Vandermeeren, Yves
- Published
- 2011
34. Postoperative analgesic effect of cathodal tDCS. Resident Meeting of the BSAR
- Author
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UCL - SSS/IONS/NEUR - Clinical Neuroscience, UCL - (MGD) Service de neurologie, UCL - (MGD) Service d'anesthésiologie, UCL - (MGD) Unité de support scientifique, UCL - SSH/IACS - Institute of Analysis of Change in Contemporary and Historical Societies, UCL - SSS/IREC/MONT - Pôle Mont Godinne, Somja, G, Vandermeeren, Yves, Jamart, Jacques, Ossemann, Michel, Gourdin, Maximilien, Dubois, Philippe E, UCL - SSS/IONS/NEUR - Clinical Neuroscience, UCL - (MGD) Service de neurologie, UCL - (MGD) Service d'anesthésiologie, UCL - (MGD) Unité de support scientifique, UCL - SSH/IACS - Institute of Analysis of Change in Contemporary and Historical Societies, UCL - SSS/IREC/MONT - Pôle Mont Godinne, Somja, G, Vandermeeren, Yves, Jamart, Jacques, Ossemann, Michel, Gourdin, Maximilien, and Dubois, Philippe E
- Published
- 2011
35. Epileptic syndromes: differential treatment in infants, children, and adolescents.
- Author
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UCL - SSS/IONS/NEUR - Clinical Neuroscience, UCL - (SLuc) Service de neurologie, UCL - (SLuc) Service de neurologie pédiatrique, UCL - (MGD) Service de neurologie, Foulon, M, Aeby, A, Buzatu, M, Christiaens, Florence, de Borchgrave, V, de Cocq, C, de Tourtchaninoff, Marianne, Dubru, J M, Ghariani, S, Grisar, T, Legros, B, Lienard, F, Ossemann, Michel, Tugendhaft, P, van Bogaert, P, Van Rijckevorsel, Germaine, Verheulpen, D, Vrielynck, P, UCL - SSS/IONS/NEUR - Clinical Neuroscience, UCL - (SLuc) Service de neurologie, UCL - (SLuc) Service de neurologie pédiatrique, UCL - (MGD) Service de neurologie, Foulon, M, Aeby, A, Buzatu, M, Christiaens, Florence, de Borchgrave, V, de Cocq, C, de Tourtchaninoff, Marianne, Dubru, J M, Ghariani, S, Grisar, T, Legros, B, Lienard, F, Ossemann, Michel, Tugendhaft, P, van Bogaert, P, Van Rijckevorsel, Germaine, Verheulpen, D, and Vrielynck, P
- Abstract
This paper proposes therapeutic guidelines for the management of some epileptic syndromes in infants, children, and adolescents, based on available medical literature and clinical practice in the French Community of Belgium. The guidelines address both epileptic encephalopathies (West syndrome, Lennox-Gastaut syndrome, and Dravet syndrome) and idiopathic epilepsies (typical absence seizures, epilepsy with centro-temporal spikes and juvenile myoclonic epilepsy).
- Published
- 2011
36. Superficial siderosis associated with multiple dural tears opening into a spinal epidural fluid collection.
- Author
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UCL - (MGD) Service de neurologie, UCL - SSS/IREC/MONT - Pôle Mont Godinne, UCL - SSS/IONS - Institute of NeuroScience, UCL - SSS/IONS/NEUR - Clinical Neuroscience, UCL - (MGD) Service de radiologie - résonance magnétique, UCL - (SLuc) Service de radiologie, Wertz, Marie, Cosnard, Guy, Misson, Nicolas, Ossemann, Michel, Mormont, Eric, Laloux, Patrice, Vandermeeren, Yves, UCL - (MGD) Service de neurologie, UCL - SSS/IREC/MONT - Pôle Mont Godinne, UCL - SSS/IONS - Institute of NeuroScience, UCL - SSS/IONS/NEUR - Clinical Neuroscience, UCL - (MGD) Service de radiologie - résonance magnétique, UCL - (SLuc) Service de radiologie, Wertz, Marie, Cosnard, Guy, Misson, Nicolas, Ossemann, Michel, Mormont, Eric, Laloux, Patrice, and Vandermeeren, Yves
- Published
- 2011
37. Effect of tDCS with an extracephalic reference electrode on cardio-respiratory and autonomic functions.
- Author
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UCL - SSS/IONS/NEUR - Clinical Neuroscience, UCL - (MGD) Service de neurologie, UCL - SSS/IONS - Institute of NeuroScience, UCL - SSS/IREC - Institut de recherche expérimentale et clinique, UCL - SSS/IREC/MONT - Pôle Mont Godinne, UCL - (MGD) Unité de support scientifique, Vandermeeren, Yves, Jamart, Jacques, Ossemann, Michel, UCL - SSS/IONS/NEUR - Clinical Neuroscience, UCL - (MGD) Service de neurologie, UCL - SSS/IONS - Institute of NeuroScience, UCL - SSS/IREC - Institut de recherche expérimentale et clinique, UCL - SSS/IREC/MONT - Pôle Mont Godinne, UCL - (MGD) Unité de support scientifique, Vandermeeren, Yves, Jamart, Jacques, and Ossemann, Michel
- Abstract
BACKGROUND: Transcranial direct current stimulation (tDCS) is used in human physiological studies and for therapeutic trials in patients with abnormalities of cortical excitability. Its safety profile places tDCS in the pole-position for translating in real-world therapeutic application. However, an episode of transient respiratory depression in a subject receiving tDCS with an extracephalic electrode led to the suggestion that such an electrode montage could modulate the brainstem autonomic centres. We investigated whether tDCS applied over the midline frontal cortex in 30 healthy volunteers (sham n = 10, cathodal n = 10, anodal n = 10) with an extracephalic reference electrode would modulate brainstem activity as reflected by the monitoring and stringent analysis of vital parameters: heart rate (variability), respiratory rate, blood pressure and sympatho-vagal balance. We reasoned that this study could lead to two opposite but equally interesting outcomes: 1) If tDCS with an extracephalic electrode modulated vital parameters, it could be used as a new tool to explore the autonomic nervous system and, even, to modulate its activity for therapeutic purposes. 2) On the opposite, if applying tDCS with an extracephalic electrode had no effect, it could thus be used safely in healthy human subjects. This outcome would significantly impact the field of non-invasive brain stimulation with tDCS. Indeed, on the one hand, using an extracephalic electrode as a genuine neutral reference (as opposed to the classical "bi-cephalic" tDCS montages which deliver bi-polar stimulation of the brain) would help to comfort the conclusions of several modern studies regarding the spatial location and polarity of tDCS. On the other hand, using an extracephalic reference electrode may impact differently on a given cortical target due to the change of direct current flow direction; this may enlarge the potential interventions with tDCS. RESULTS: Whereas the respiratory frequency decreased mil
- Published
- 2010
38. Recurrence of cluster headache with pramipexole.
- Author
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UCL - SSS/IONS/NEUR - Clinical Neuroscience, UCL - (MGD) Service de neurologie, UCL - SSS/IONS - Institute of NeuroScience, Ossemann, Michel, UCL - SSS/IONS/NEUR - Clinical Neuroscience, UCL - (MGD) Service de neurologie, UCL - SSS/IONS - Institute of NeuroScience, and Ossemann, Michel
- Abstract
Cluster headache (CH) is among the most painful headache disorders. There is still no unifying pathophysiological hypothesis to explain the trigeminal distribution, the circadian periodicity and the autonomic symptoms of the syndrome. We report the case of a patient with worsening of CH following administration of pramipexole for a restless legs syndrome (RLS). This observation supports the hypothesis that the dopaminergic system may play a role in the genesis or trigger of CH.
- Published
- 2010
39. Recommendations for the treatment of epilepsies in general practice in Belgium
- Author
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UCL - (MGD) Service de neurologie, UCL - MD/NOPS - Département de neurologie et de psychiatrie, Boon, Paul, Engelborghs, Sebastiaan, Hauman, Henri, Jansen, An, Lagae, Lieven, Legros, Benjamin, Ossemann, Michel, Sadzot, Bernard, Urbain, Etienne, van Rijckevorsel, Kenou, UCL - (MGD) Service de neurologie, UCL - MD/NOPS - Département de neurologie et de psychiatrie, Boon, Paul, Engelborghs, Sebastiaan, Hauman, Henri, Jansen, An, Lagae, Lieven, Legros, Benjamin, Ossemann, Michel, Sadzot, Bernard, Urbain, Etienne, and van Rijckevorsel, Kenou
- Abstract
The large choice of antiepileptic drugs (AEDs) in Belgium complicates the selection of the appropriate product for the individual patient. International guidelines on the treatment of epilepsy have been published, but are not tailored to the Belgian situation. This publication presents recommendations from a group of Belgian epilepsy experts for the practical management of epilepsy in general practice in Belgium. It includes recommendations for initial monotherapy and add-on treatment in adult patients (>= 16 years) and initial monotherapy in paediatric patients (< 16 years). For these three situations a first choice AED is recommended. One or more alternative first choice AEDs are defined for patients in which certain patient- or AED-related factors preclude the use of the first choice product. Selection of compounds was based on the registration and reimbursement status in Belgium, the level of evidence of efficacy, common daily practice and the personal views and experiences of the authors. The paper reflects the situation in 2008. In addition to the treatment recommendations, other relevant points to consider in the treatment of epilepsy with AEDs are addressed, including comorbidity and age of the patient, the interaction potential, pharmacokinetic properties and safety profile of the AEDs, and generic substitution.
- Published
- 2008
40. Recommendations for the treatment of epilepsies in general practice in Belgium
- Author
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Boon, Paul, Engelborghs, Sebastiaan, Hauman, Henri, Jansen, An, Lagae, Lieven, Legros, Benjamin, Ossemann, Michel, Sadzot, Bernard, Urbain, Etienne, Van Rijckevorsel, Kenou, Boon, Paul, Engelborghs, Sebastiaan, Hauman, Henri, Jansen, An, Lagae, Lieven, Legros, Benjamin, Ossemann, Michel, Sadzot, Bernard, Urbain, Etienne, and Van Rijckevorsel, Kenou
- Abstract
The large choice of antiepileptic drugs (AEDs) in Belgium complicates the selection of the appropriate product for the individual patient. International guide-lines on the treatment of epilepsy have been published, but are not tailored to the Belgian situation. This publication presents recommendations from a group of Belgian epilepsy experts for the practical management of epilepsy in general practice in Belgium. It includes recommendations for initial monotherapy and add-on treatment in adult patients (≥ 16 years) and initial monotherapy in paediatric patients (< 16 years). For these three situations a first choice AED is recommended. One or more alternative first choice AEDs are defined for patients in which certain patient- or AED-related factors preclude the use of the first choice product. Selection of compounds was based on the registration and reimbursement status in Belgium, the level of evidence of efficacy, common daily practice and the personal views and experiences of the authors. The paper reflects the situation in 2008. In addition to the treatment recommendations, other relevant points to consider in the treatment of epilepsy with AEDs are addressed, including comorbidity and age of the patient, the interaction potential, pharmacokinetic properties and safety profile of the AEDs, and generic substitution., SCOPUS: ar.j, info:eu-repo/semantics/published
- Published
- 2008
41. Family history of hypertension is not an independent genetic factor predisposing to ischemic stroke subtypes.
- Author
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UCL - (MGD) Service de neurologie, UCL - MD/NOPS - Département de neurologie et de psychiatrie, Laloux, Patrice, Ossemann, Michel, Jamart, Jacques, UCL - (MGD) Service de neurologie, UCL - MD/NOPS - Département de neurologie et de psychiatrie, Laloux, Patrice, Ossemann, Michel, and Jamart, Jacques
- Abstract
OBJECTIVES: The effect of family history of hypertension (FHx(HT)), as a genetic factor predisposing to some ischemic stroke subtypes and independently of hypertension as risk factor, has never been studied. METHODS: A positive FHx(HT) was searched in 472 patients (312 men, 160 women; mean [S.D.] age, 67.9 [11.4] years) consecutively admitted for a first-ever ischemic stroke (348) or transient ischemic attack (TIA) (124) due to small vessel disease (SVD, 180), large vessel disease (156), or cardioembolism (136). In this population and in three age bands, the genetically transmitted vascular risk factors, age, gender and the ischemic stroke subtypes were compared between those with and without a positive FHx(HT). RESULTS: None of the risk factors was associated with a positive FHx(HT), except for hypertension in the whole population (68.9% vs. 48.7%; p=0.001) and in the <65 year-old patients (72.5% vs. 39.5%; p<0.001). Regarding the stroke subtypes, a positive FHx(HT) was only associated with SVD in the subgroup of <65 year-old patients (odd ratios (OR), 2.07; 95% confidence interval (CI), 1.01 to 4.25; p=0.045). However, this finding disappeared in a logistic regression analysis, which only retained hypertension as independently associated with SVD. CONCLUSIONS: FHx(HT) is not an independent genetic factor predisposing to some aetiological stroke subtypes.
- Published
- 2007
42. Miller Fisher variant syndrome, an unusual and severe clinical presentation: a case report
- Author
-
UCL - (MGD) Service de neurologie, UCL - MD/MINT - Département de médecine interne, UCL - (MGD) Services des soins intensifs, UCL - MD/NOPS - Département de neurologie et de psychiatrie, Gérard, Véronique, Ossemann, Michel, Dive, Alain-Michel, UCL - (MGD) Service de neurologie, UCL - MD/MINT - Département de médecine interne, UCL - (MGD) Services des soins intensifs, UCL - MD/NOPS - Département de neurologie et de psychiatrie, Gérard, Véronique, Ossemann, Michel, and Dive, Alain-Michel
- Published
- 2007
43. Guidelines for the management of epilepsy in the elderly.
- Author
-
UCL - (SLuc) Service de neurologie, UCL - (MGD) Service de neurologie, UCL - MD/NOPS - Département de neurologie et de psychiatrie, UCL - MD/FSIO - Département de physiologie et pharmacologie, UCL - (SLuc) Centre neurologique William Lennox, UCL - (SLuc) Centre de référence pour l'épilepsie réfractaire, Ossemann, Michel, Bruls, E, de Borchgrave, V, Decock, Cony, Delcourt, C, Delvaux, V., Depondt, C, de Tourtchaninoff, Marianne, Grisar, T, Legros, B., Liénard, Françoise, Lievens, I, Sadzot, B, Van Rijckevorsel, Germaine, UCL - (SLuc) Service de neurologie, UCL - (MGD) Service de neurologie, UCL - MD/NOPS - Département de neurologie et de psychiatrie, UCL - MD/FSIO - Département de physiologie et pharmacologie, UCL - (SLuc) Centre neurologique William Lennox, UCL - (SLuc) Centre de référence pour l'épilepsie réfractaire, Ossemann, Michel, Bruls, E, de Borchgrave, V, Decock, Cony, Delcourt, C, Delvaux, V., Depondt, C, de Tourtchaninoff, Marianne, Grisar, T, Legros, B., Liénard, Françoise, Lievens, I, Sadzot, B, and Van Rijckevorsel, Germaine
- Abstract
Seizures starting in patients over 60 years old are frequent. Diagnosis is sometimes difficult and frequently under- or overrated. Cerebrovascular disorders are the main cause of a first seizure. Because of more frequent comorbidities, physiologic changes, and a higher sensitivity to drugs, treatment has some specificity in elderly people. The aim of this paper is to present the result of a consensus meeting held in October 2004 by a Belgian French-speaking group of epileptologists and to propose guidelines for the management and the treatment of epilepsy in elderly people.
- Published
- 2006
44. Valproate-induced hyperammonaemic encephalopathy revealing adult onset ornithine transcarbamylase deficiency: about an unusual case
- Author
-
UCL - (MGD) Service de neurologie, UCL - Cliniques universitaires Saint-Luc, UCL - MD/NOPS - Département de neurologie et de psychiatrie, UCL - MD/GYPE - Département de gynécologie, d'obstétrique et de pédiatrie, UCL - (SLuc) Service de neurologie pédiatrique, Rage, Michael, Nassogne, Marie-Cécile, Laloux, Patrice, Ossemann, Michel, UCL - (MGD) Service de neurologie, UCL - Cliniques universitaires Saint-Luc, UCL - MD/NOPS - Département de neurologie et de psychiatrie, UCL - MD/GYPE - Département de gynécologie, d'obstétrique et de pédiatrie, UCL - (SLuc) Service de neurologie pédiatrique, Rage, Michael, Nassogne, Marie-Cécile, Laloux, Patrice, and Ossemann, Michel
- Published
- 2006
45. The epileptic syndromes with continuous spikes and waves during slow sleep: definition and management guidelines.
- Author
-
UCL - SSS/IREC/MONT - Pôle Mont Godinne, UCL - (MGD) Service de neurologie, Van Bogaert, P, Aeby, A, De Borchgrave, V, De Cocq, C, Deprez, M, De Tiège, X, de Tourtchaninoff, M, Dubru, J M, Foulon, M, Ghariani, S, Grisar, T, Legros, B, Ossemann, Michel, Tugendhaft, P, van Rijckevorsel, K, Verheulpen, D, Groupe de travail des centres francophones de référence de l'epilepsie réfractaire, UCL - SSS/IREC/MONT - Pôle Mont Godinne, UCL - (MGD) Service de neurologie, Van Bogaert, P, Aeby, A, De Borchgrave, V, De Cocq, C, Deprez, M, De Tiège, X, de Tourtchaninoff, M, Dubru, J M, Foulon, M, Ghariani, S, Grisar, T, Legros, B, Ossemann, Michel, Tugendhaft, P, van Rijckevorsel, K, Verheulpen, D, and Groupe de travail des centres francophones de référence de l'epilepsie réfractaire
- Abstract
The authors propose to define the epileptic syndromes with continuous spikes and waves during slow sleep (CSWS) as a cognitive or behavioral impairment acquired during childhood, associated with a strong activation of the interictal epileptiform discharges during NREM sleep--whatever focal or generalized--and not related to another factor than the presence of CSWS. The type of syndrome will be defined according to the neurological and neuropsychological deficit. These syndromes have to be classified among the localization-related epileptic syndromes. Some cases are idiopathic and others are symptomatic. Guidelines for work-up and treatment are proposed.
- Published
- 2006
46. Standards of care for adults with convulsive status epilepticus: Belgian consensus recommendations.
- Author
-
UCL - (MGD) Service de neurologie, UCL - MD/NOPS - Département de neurologie et de psychiatrie, Van Rijckevorsel, Germaine, Boon, Paul, Hauman, Henri, Legros, Benjamin, Ossemann, Michel, Sadzot, Bernard, Schmedding, Eric, Van Zandijcke, Michel, UCL - (MGD) Service de neurologie, UCL - MD/NOPS - Département de neurologie et de psychiatrie, Van Rijckevorsel, Germaine, Boon, Paul, Hauman, Henri, Legros, Benjamin, Ossemann, Michel, Sadzot, Bernard, Schmedding, Eric, and Van Zandijcke, Michel
- Abstract
Status epilepticus (SE) is a significant health problem, affecting approximately 1,000 to 4,000 individuals per year in Belgium. A workshop was convened by a panel of neurologists from major Belgian centers to review the latest information relating to the definition, diagnosis and treatment of convulsive SE. The panelists sought to make recommendations for practising neurologists, but also primary care physicians and physicians in intensive care units when initiating emergency measures for patients with convulsive SE. As there is an association between prolonged seizures and a poor outcome, the importance of early (within the first 5 minutes of seizure onset) and aggressive treatment is to be stressed. In addition to general systemic support (airway, circulation), intravenous administration of the benzodiazepines lorazepam or diazepam is recommended as first-line therapy. Intramuscular midazolam may also be used. If SE persists, second-line drugs include phenytoin or valproate, and third-line drugs the barbiturate phenobarbital, the benzodiazepine midazolam, or the anaesthetics thiopental or propofol, or eventually ketamine. If the patient does not recover after therapy, monitoring of seizures should involve an electroencephalogram to avoid overlooking persistence of clinically silent SE. As a general rule, the intensity of the treatment should reflect the risk to the patient from SE, and drugs likely to depress respiration and blood pressure should initially be avoided. If initial treatment with a benzodiazepine fails to control seizures, the patient must be referred to the emergency unit and a neurologist should be contacted immediately.
- Published
- 2005
47. Standards of care for adults with convulsive status epilepticus: Belgian consensus recommendations
- Author
-
Van Rijckevorsel, Kenou, Boon, Paul, Hauman, Henri, Legros, Benjamin, Ossemann, Michel, Sadzot, Bernard, Schmedding, Eric, Van Zandijcke, Michel, Van Rijckevorsel, Kenou, Boon, Paul, Hauman, Henri, Legros, Benjamin, Ossemann, Michel, Sadzot, Bernard, Schmedding, Eric, and Van Zandijcke, Michel
- Abstract
Status epilepticus (SE) is a significant health problem, affecting approximately 1,000 to 4,000 individuals per year in Belgium. A workshop was convened by a panel of neurologists from major Belgian centers to review the latest information relating to the definition, diagnosis and treatment of convulsive SE. The panelists sought to make recommendations for practising neurologists, but also primary care physicians and physicians in intensive care units when initiating emergency measures for patients with convulsive SE. As there is an association between prolonged seizures and a poor outcome, the importance of early (within the first 5 minutes of seizure onset) and aggressive treatment is to be stressed. In addition to general systemic support (airway, circulation), intravenous administration of the benzodiazepines lorazepam or diazepam is recommended as first-line therapy. Intramuscular midazolam may also be used. If SE persists, second-line drugs include phenytoin or valproate, and third-line drugs the barbiturate phenobarbital, the benzodiazepine midazolam, or the anaesthetics thiopental or propofol, or eventually ketamine. If the patient does not recover after therapy, monitoring of seizures should involve an electroencephalogram to avoid overlooking persistence of clinically silent SE. As a general rule, the intensity of the treatment should reflect the risk to the patient from SE, and drugs likely to depress respiration and blood pressure should initially be avoided. If initial treatment with a benzodiazepine fails to control seizures, the patient must be referred to the emergency unit and a neurologist should be contacted immediately., SCOPUS: re.j, info:eu-repo/semantics/published
- Published
- 2005
48. Guidelines for recognition and treatment of the psychoses associated with epilepsy
- Author
-
Tugendhaft, Patrick, Ansseau, Mélanie, de Borchgrave d'Alténa, Valérie, Delvaux, V, De Tourtchaninoff, Marianne, Dubru, Jean Marie, Floris, Michel, Foulon, Martine, Grisar, Thierry, Hmaimess, Ghassan, Legros, Benjamin, Mahieu, B., Ossemann, Michel, Sadzot, Bernard, Van Rijckevorsel, Kenou, Verheulpen, Denis, Tugendhaft, Patrick, Ansseau, Mélanie, de Borchgrave d'Alténa, Valérie, Delvaux, V, De Tourtchaninoff, Marianne, Dubru, Jean Marie, Floris, Michel, Foulon, Martine, Grisar, Thierry, Hmaimess, Ghassan, Legros, Benjamin, Mahieu, B., Ossemann, Michel, Sadzot, Bernard, Van Rijckevorsel, Kenou, and Verheulpen, Denis
- Abstract
Epilepsy and psychiatric diseases are frequent comorbidities. Psychoses in patients with epilepsy have special physiopathology and several clinical presentations and prognoses. Their treatments are also specific, according to the specific diagnosis. This paper represents the summary of a consensus meeting held in November 2003 by a Belgian French-speaking group of neurologists, neuropediatricians and psychiatrists and proposes guidelines for the recognition and treatment of those entities., SCOPUS: ar.j, info:eu-repo/semantics/published
- Published
- 2005
49. Prophylaxis of the epilepsies: should anti-epileptic drugs be used for preventing seizures after acute brain injury?
- Author
-
UCL - SSS/IREC/MONT - Pôle Mont Godinne, UCL - (MGD) Service de neurologie, Grisar, T, Bottin, P, de Borchgrave d'Alténa, V, Brichart, C, Delcourt, C, Dubru, J M, Foulon, M, Ghariani, S, Hotermans, C, Legros, B, Ossemann, Michel, Sadzot, B, Tugendhaft, P, Van Bogaert, P, van Rijckevorsel, K, Verheulpen, D, UCL - SSS/IREC/MONT - Pôle Mont Godinne, UCL - (MGD) Service de neurologie, Grisar, T, Bottin, P, de Borchgrave d'Alténa, V, Brichart, C, Delcourt, C, Dubru, J M, Foulon, M, Ghariani, S, Hotermans, C, Legros, B, Ossemann, Michel, Sadzot, B, Tugendhaft, P, Van Bogaert, P, van Rijckevorsel, K, and Verheulpen, D
- Abstract
In many circumstances antiepileptic drugs are used in patients who have never presented any clinical epileptic seizures. These substances are administered on the assumption of a potential risk for the patients of developing acute or delayed chronic seizures after brain injuries such as trauma, stroke, hemorrages or even neurosurgical interventions. The aim of this paper is to propose therapeutic guidelines for the management of this prophylactic attitude in epilepsy based on basic research and clinical practice in the French community in Belgium. We will distinguish between the prevention of acute (early onset-provoked) seizures and a delayed truly post-lesional (unprovoked) epilepsy. Some therapeutic goals can be achieved under the former circumstances whereas in the latter situation we all agree for the absence of any coherent antiepileptic prophylactic behaviour.
- Published
- 2005
50. Guidelines for recognition and treatment of the psychoses associated with epilepsy.
- Author
-
UCL - SSS/IREC/MONT - Pôle Mont Godinne, UCL - (MGD) Service de neurologie, Tugendhaft, P, Ansseau, M, de Borchgrave, V, Delvaux, V, de Tourtchaninoff, M, Dubru, J M, Floris, M, Foulon, M, Grisar, T, Hmaimess, G, Legros, B, Mahieu, B, Ossemann, Michel, Sadzot, B, van Ruckevorsel, K, Verheulpen, D, UCL - SSS/IREC/MONT - Pôle Mont Godinne, UCL - (MGD) Service de neurologie, Tugendhaft, P, Ansseau, M, de Borchgrave, V, Delvaux, V, de Tourtchaninoff, M, Dubru, J M, Floris, M, Foulon, M, Grisar, T, Hmaimess, G, Legros, B, Mahieu, B, Ossemann, Michel, Sadzot, B, van Ruckevorsel, K, and Verheulpen, D
- Abstract
Epilepsy and psychiatric diseases are frequent comorbidities. Psychoses in patients with epilepsy have special physiopathology and several clinical presentations and prognoses. Their treatments are also specific, according to the specific diagnosis. This paper represents the summary of a consensus meeting held in November 2003 by a Belgian French-speaking group of neurologists, neuropediatricians and psychiatrists and proposes guidelines for the recognition and treatment of those entities.
- Published
- 2005
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