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Applications of graph mining have proliferated across the research spectrum in recent years. Mining data to retrieve information is a big deal as data are unstructured and huge in size, volume and in different data-types as internet is available to everyone and anywhere. Therefore data is so rapidly increased and for that point this mining concept came. In graph mining, analysis of graph base data is considered. In different research fields use graph base mining as it give quick and efficient result of large datasets. Here we consider biological data which are very complex to describe and analyse to extract useful information, so now researchers use computational tools to mine the large datasets, graphs are the most efficiently used. We consider amino acid network to do graph mining and extract some useful patterns from the network. Amino Acid Networks (AANs) are undirected graphs where amino acids are act like vertices and their relationships connect two vertices in protein structures. Every amino acid exhibits different physico-chemical properties. The shift in R groups affects various characteristics of the amino acids. The shift in R groups affects the various characteristics of the amino acids. In this paper we have construct a graph of amino acids based on property similarity and discussed different measures of centrality. We have also investigated the correlation coefficients between different measures of centrality.

Abstract Highly crystalline organic semiconductors are ideal materials for photocatalytic hydrogen evolution in water splitting. However, the instability and complex synthesis processes of most reported organic molecule‐based photocatalysts restrict their applications. In this study, we introduce benzo [1,2‐b:4,5‐bʹ] bis [1] benzothiophene‐3,9‐dicarboxylic acid, 5,5,11,11‐tetraoxide (FSOCA), a highly crystalline, stable molecular crystal that is easy to synthesize and serves as an efficient photocatalyst for the hydrogen evolution reaction. FSOCA exhibits high efficiency in sacrificial hydrogen evolution reaction (760 µmol h−1, 76 mmol g−1 h−1 at 330 mW cm−2; 570 µmol h−1, 57 mmol g−1 h−1 at 250 mW cm−2), and FSOCA remains stable during photocatalysis for up to 400 h. Experiments and theoretical studies confirmed the presence of hydrogen bonds between the sulfone group and the sacrificial agent (ascorbic acid). This interaction significantly improved the oxidation reaction kinetics and boosted the photocatalytic performance. This study presents a scalable and convenient approach to synthesize highly crystalline, active, and stable organic photocatalysts with potential applications in large‐scale photocatalysis.

Abstract Microorganism contamination on substrate surfaces is arousing increasingly concern as a serious health issue. In this research work, antimicrobial water-based acrylic paint containing silver nanoparticles (Ag NPs) was prepared using the facile Ag+ in situ reduction process, in which AgNO3 and reducing agent sodium acrylate were refluxed with acrylic polymeric solution to obtain an antimicrobial and antifungal polymeric material for substrate coating. The Synthesized antimicrobial and antifungal water-based acrylic paint were characterized by different spectroscopic techniques. The FTIR and UV–Visible spectroscopic analyses were investigated to study the water-based acrylic paint structure as well as the significant impact of Ag NPs on the paint matrix. The UV–Visible and FTIR Spectra peak shows successful integration of Ag NPs within the polymer matrix without altering the core functional groups of the paint. The water based acrylic paint exhibited a strong antimicrobial activity, revealed substantial inhibition zones against all four strains of Gram negative represented by Escherichia coli, Acinetobacter baumannii, Klebsiella pneumoniae and Gram-positive represented by Bacillus cereus. The coated film on substrate also shows great inhibition zone which exhibit a strong antimicrobial activity. Moreover, water based acrylic paint also exhibited a great antifungal activity, revealed substantial zone of inhibition against the Aspergillus niger, Aspergillus terreus and Rhizopus arrhizus fungal strains. Also, the coated film showed the best adhesion at 50% and 80% solution of polymeric coating sample as compared to pure or very dilute sample coating. This innovative approach has the potential to revolutionize varies industries from healthcare to construction.

Background: The presence of perinatal asphyxia and its severity appear to correlate with increasing incidence of Acute kidney injury (AKI). The objective of this study is to determine the frequency of AKI and its outcome in birth asphyxia. Methods: This cross-sectional study was carried out in the Department of Pediatric Medicine from March 2019 to September 2019. A total of 111 newborns with birth asphyxia of gestational age 37–41 weeks were included. Neonates born to mothers having hypertension and diabetes mellitus, patients with congenital kidney anomalies like polycystic kidney disease and renal agenesis, and mothers taking nephrotoxic drugs or any other known cause of AKI like hypovolemic shock were excluded. Urine output (UOP) and final outcome of the patient were also noted. AKI was noted. Results: The mean gestational age was 38.29 ± 1.07 weeks. The mean weight of neonates was 3.08 ± 0.31 kg. The frequency of AKI in birth asphyxia was 20 (18.02%) neonates. Complete recovery in AKI patients was seen in 07 (35.0%) and death in 13 (65.0%) patients. Conclusion: This study has shown that the frequency of AKI in birth asphyxia was found in 18.02% neonates with complete recovery seen in 35.0% and death in 65.0% patients.

Abstract The use of light to regulate photocatalyzed reversible deactivation radical polymerization (RDRP) under mild conditions, especially driven by broadband light or sunlight directly, is highly desired. But the development of a suitable photocatalyzed polymerization system for large-scale production of polymers, especially block copolymers, has remained a big challenge. Herein, we report the development of a phosphine-based conjugated hypercrosslinked polymer (PPh3-CHCP) photocatalyst for an efficient large-scale photoinduced copper-catalyzed atom transfer radical polymerization (Cu-ATRP). Monomers including acrylates and methyl acrylates can achieve near-quantitative conversions under a wide range (450–940 nm) of radiations or sunlight directly. The photocatalyst could be easily recycled and reused. The sunlight-driven Cu-ATRP allowed the synthesis of homopolymers at 200 mL from various monomers, and monomer conversions approached 99% in clouds intermittency with good control over polydispersity. In addition, block copolymers at 400 mL scale can also be obtained, which demonstrates its great potential for industrial applications.

AbstractThis study is an attempt to estimate the incidence, severity, depth, and determinants of poverty in Jhang district, Punjab, Pakistan. For this purpose, the data were collected from 1,000 households through a specifically designed questionnaire using multistages sampling technique in all four subdistricts of Jhang district. The study used both income-regression model and logistic regression to assess the impact of demographic and socioeconomic factors on poverty incidence. The results show that 54.3% of households are below the poverty line, including 16% extremely poor. Poverty measures including headcount index, severity, and depth of poverty are worse among the households headed by farmers, daily-wagers, and illiterates. Moreover, the results confirm that the household’s livestock population, landholding, ownership of agricultural land, total assets, and earners per household considerably reduced the poverty incidence in Jhang district. While household size, age of household head, economic dependency ratio, and total dependency ratio significantly increased the level of poverty. The study concludes that demographic and socioeconomic characteristics of the households are of greater importance in alleviating poverty generally in Pakistan but particularly in rural areas. Hence, it is suggested that governments should increase public spending on socioeconomic programs and services with a particular focus on education, women’s empowerment, family planning, employment opportunity, pro-agriculture policies, and equitable distribution of land and wealth to alleviate poverty in rural areas of Pakistan. Further research can be conducted by selecting large sample size and analyzing the household characteristics at the disaggregated level incorporating time variations to develop a more impactful policy framework.

Speech enhancement (SE) aims to improve the intelligibility and perceptual quality of speech contaminated by noise signals through spectral or temporal changes. Deep learning models achieve speech enhancement and estimate the magnitude spectrum. This paper proposes a novel and computationally efficient deep learning model to enhance noisy speech. The model pre-processes the noisy speech magnitude by redistributing energy from high-energy voiced segments to low-energy unvoiced segments using an adaptive power law transformation while maintaining the total energy of the speech signals constant. A U-shaped fuzzy long short-term memory (UFLSTM) estimates the magnitude of a time-frequency (T-F) mask by using the pre-processed data. Residual connections to the similar-shaped layers are added to avoid gradient decay. Attention process is adopted by modifying the forget gate of UFLSTM. To make a causal speech enhancement system, the processing does not include any future audio frames. We compare the proposed speech enhancement to other deep learning models in different noisy environments with signal-to-noise ratios of 0 dB, 5 dB, and 10 dB. The experiments show that the proposed SE system outscores the competing deep learning models and considerably improves speech intelligibility and quality. In terms of STOI and PESQ, the LibriSpeech database improves results by (0.211) 21.1% and (0.95) 36.39%, respectively, over noisy speech in seen noisy conditions, and by (0.199) 19.9% and (0.94) 35.69% over noisy speech in unseen noisy conditions. Further, the cross-corpus analysis shows that proposed SE system performs better when trained with the DNS dataset as compared to the LibriSpeech, VoiceBank, and TIMIT datasets.

Abstract Background Selecting American mink (Neovison vison) for tolerance to Aleutian mink disease virus (AMDV) has gained popularity in recent years, but data on the outcomes of this activity are scant. The objectives of this study were to determine the long-term changes in viremia, seroconversion and survival in infected mink. Mink were inoculated intranasally with a local isolate of Aleutian mink disease virus (AMDV) over 4 years (n = 1742). The animals had been selected for tolerance to AMDV for more than 20 years (TG100) or were from herds free of AMDV (TG0). The progenies of TG100 and TG0, and their crosses with 25, 50 and 75% tolerance ancestry were also used. Blood samples were collected from each mink up to 14 times until 1211 days post-inoculation (dpi) and were tested for viremia by PCR and for anti-AMDV antibodies by counter-immunoelectrophoresis (CIEP). Viremia and CIEP status were not considered when selecting replacements. Low-performing animals were pelted and the presence of antibodies in their blood and antibody titer were measured by CIEP, and viremia and viral DNA in seven organs (n = 936) were tested by PCR. Results The peak incidences of viremia (66.7%) and seropositivity (93.5%) were at 35 dpi. The incidence of viremia decreased over time while the incidence of seroconversion increased. The least-squares means of the incidence of PCR positive of lymph node (0.743) and spleen (0.656) were significantly greater than those of bone marrow, liver, kidneys, lungs and small intestine (0.194 to 0.342). Differences in tolerant ancestry were significant for every trait measured. Incidences of viremia over time, terminal viremia, seropositivity over time, AMDV DNA in organs and antibody titer were highest in the susceptible groups (TG0 or TG25) and lowest in the tolerant groups (TG100 or TG75). Conclusion Previous history of selection for tolerance resulted in mink with reduced viral replication and antibody titer. Viremia had a negative effect and antibody production had a positive effect on survival and productivity.

Traditionally, export supply is modelled as a function of production capacity, cost and prices. These factors are not able to fully explain the export performance. The present study includes the domestic demand pressure as an additional explanatory variable in the traditional export supply model to evaluate its empirical importance for modelling export supply for Pakistan. Using the Autoregressive Distributed Lag (ARDL) model (bound testing) on annual data over the period of 1971 to 2014; the results confirm that domestic demand pressure has a negative and significant effect on the supply of aggregate, primary and manufactured exports in both the long- and shortrun periods. However, the short-run coefficients of domestic demand are much greater in magnitude in all three cases, implying that changes in domestic demand have a larger effect on export growth in the short-run. Finally, the study concludes that along with the traditional factors, domestic demand pressure is also relevant for modelling the export performance of Pakistan at both the aggregate and disaggregated levels.

Objective: To compare the frequency of Pseudo-Exfoliation Syndrome (PXS) in patients undergoing cataract surgery in different regional hospitals in Pakistan. Study Design: Cross-sectional study. Place and Duration of Study: Three Tertiary Care Hospitals of Karachi, Rawalakot and Skardu Pakistan, from Sep 2017 to May 2020. Methodology: Patients aged 45 years and more undergoing age-related cataract surgery were evaluated for Pseudo-Exfoliation Syndrome. Initially, each patient underwent a complete outpatient ophthalmological workup. Demographic details like age and gender were noted. All the patients were screened for hypertension and diabetes mellitus. In addition, patients were screened for pseudo-exfoliation syndrome. Congenital, developmental, secondary and traumatic cataracts were excluded. Results: A total of 1882 patients were included in the study. Pseudo-exfoliation was carried out in 249(13.23%) patients. In Hospital-A, 23(3.23%); in Hospital-B, 145(14.92%) and Hospital-C, 81(40.70%) of the patients had pseudo-exfoliation. The frequency of pseudo-exfoliation syndrome was significantly more in Hospital-C and then in Hospital-B and least in HospitalA (p

Objective: To assess the frequency of dry eye among children during the COVID-19 pandemic. Study Design: Cross-sectional study. Place and Duration of Study: Pakistan Naval Ship Hafeez Hospital, Islamabad Pakistan, from Mar to Aug 2021. Methodology: Children aged 7-15 years reporting to the PNS Hafeez Hospital, OPD were included in the study. A proforma was used to record the demographics and screen time of the children. In addition, an ophthalmic examination was conducted to assess the dry eye status of the children using the Schirmer-II test. Results: Seventy-three children participated in the study. Their mean age was 11.08±2.42 years. There were 40(54.8%) boys and 33 (45.2%) girls. These children had a mean daily screen time of 7.23±2.77hours. Children with dry eye had a greater amount of screen time (8.75±2.11hours) as compared to those with normal tear function (6.05±2.66 hours; p

Objective: To compare the frequency of depression in low vision and normal vision patients. Study Design: Comparative cross-sectional study. Place and Duration of Study: Eye Department, Combined Military Hospital, Malir Cantt, Karachi Pakistan, from Dec 2017 to May 2019. Methodology: Patients with low vision and normal vision were evaluated for depression. Initially, each patient underwent a complete Outpatient ophthalmological workup. Then, the patients were assigned to the low vision and normal vision groups,and after informed consent, each patient was to complete Patient Health Questionnaire-9 (PHQ-9). Result: Two hundred and sixty-nine patients with low vision and 275 patients with normal vision were included in the study.One hundred and eighty-two (67.66%) patients with low vision and 71(25.82%) patients with normal vision were found to have significant depression (PHQ-9 score≥5). Depression was significantly more prevalent in the Low Vision-Group (p=

While covalent triazine frameworks are promising photocatalytic materials, it is challenging to prepare large-scale thin films. Here, authors report an interfacial polymerization method to prepare photocatalytic covalent triazine framework thin films with lateral sizes up to 250 cm2.

Objective: To assess any association between the type of cataract and the central corneal thickness at pre-operative and postoperative three-day and one-month appointments after phacoemulsification surgery. Study Design: Prospective, comparative study. Place and Duration of Study: Eye Department Combined Military Hospital Multan, from Jun 2020 to Apr 2021. Methodology: A total of 89 patients requiring cataract surgery by phacoemulsification were recruited. Age and gender were recorded for each patient. Patient’s type of cataract based on maturity was recorded before the surgery. Phacoemulsification cataract surgery using ‘divide and conquer’ technique was carried out. Patients’ central corneal thickness was measured at the pre-operative, three-day post-operative and one-month post-operative appointment using traditional non-contact tonopachymeter. Results: There were 49 (55.1%) male and 40 (44.9%) female patients with a mean age of 62.15 ± 12.40 years. No significant association was found between the type of cataract and central corneal thickness at the three-time intervals (p=0.14). Central corneal thickness significantly increased from 0.48 ± 0.04 mm pre-operatively to 0.51 ± 0.04 mm at the three-day post-operative appointment (p

This study aims to quantify land use and land cover changes before and after the 2010 flood in district Charsadda, Pakistan. Advanced geographic information systems (GIS) and remote sensing techniques (RST) evaluate land use and land cover changes. The purpose of this research is to estimate and compare the preand post-flood changes and their influences on land use and land cover changes. Land use land cover data studies are important for sustainable management of natural resources; they are becoming increasingly important for assessing the environmental impacts of economic development. Moreover, some remedial measures are adopted to develop the area's land cover to overcome future problems. Land use and land cover changes are measured using satellite images. Two instances, i.e., pre-flood and post-flood, are compared to analyze the change in land use and land cover of district Charsadda within 5 km along the Kabul River. Comparative analysis of pre-flood and post-flood imageries highlighted some drastic changes over the water body, built-up area, agricultural land, and bare land during flood instances. The study area is rural and agricultural land is dominant as compared to other land uses. We evaluated the percentage of different land use and land cover within our study area. The agricultural land found about 68.5%, barren land 22.5%, and the water body 8.8% before the flood. After inundation, the water body raised to 16.4%, bare soil increased to 26.3%, agricultural land degraded up to 57.0%, and settlements (villages) along the Kabul River were severely damaged and finished by this flood. 2010’s flood heavily damaged approximately four villages in district Nowshera, six in district Peshawar, and twenty-seven Charsadda District villages.

To evaluate the shared genetic etiology of type 2 diabetes (T2D) and coronary heart disease (CHD), we conducted a genome-wide, multi-ancestry study of genetic variation for both diseases in up to 265,678 subjects for T2D and 260,365 subjects for CHD. We identify 16 previously unreported loci for T2D and 1 locus for CHD, including a new T2D association at a missense variant in HLA-DRB5 (odds ratio (OR) = 1.29). We show that genetically mediated increase in T2D risk also confers higher CHD risk. Joint T2D-CHD analysis identified eight variants-two of which are coding-where T2D and CHD associations appear to colocalize, including a new joint T2D-CHD association at the CCDC92 locus that also replicated for T2D. The variants associated with both outcomes implicate new pathways as well as targets of existing drugs, including icosapent ethyl and adipocyte fatty-acid-binding protein.

The purpose of this study is to identify the leading causes of slope instability along a local highway in Anhui, People’s Republic of China. As part of the east expansion project, the mountain range will be excavated to create a two-way, nearly 30 m wide highway. The site’s topography consists of a hill with palm-shaped faces carved from limestone running along its sides. The geological characteristics and slope stability of the research area highlight the possibility of slope failure along both sides of the roadway. Slope stability analysis was performed in order to determine the failure mechanism and create a stable slope. Initial slope characterization and shear properties of the rock were determined by means of fieldwork and laboratory analysis. By causing wedging failure and toppling collapse, the bedding joints and discontinuity orientations increase instability, as determined by a kinematic analysis performed with DIP.6 software. The Limit Equilibrium Method (LEM) of analysis is presented in the software Slide 6.020 to illustrate the instability of the slope. The unstable condition of the slopes was determined using empirical methods that were validated and enhanced by limit equilibrium analysis.

In this article, the compact, ultra-wideband and high-gain MIMO antenna is presented for future 5G devices operating over 28 GHz and 38 GHz. The presented antenna is designed over substrate material Roger RT/Duroid 6002 with a thickness of 1.52 mm. The suggested design has dimensions of 15 mm × 10 mm and consists of stubs with loaded rectangular patch. The various stubs are loaded to antenna to improve impedance bandwidth and obtain ultra-wideband. The resultant antenna operates over a broadband of 26.5–43.7 GHz, with a peak value of gain >8 dBi. A four-port MIMO configuration is achieved to present the proposed antenna for future high data rate devices. The MIMO antenna offers isolation

The energy demand all over the world is increasing rapidly day by day. In traditional power systems, power plants are located far away from the consumer’s premises. This in turn causes a substantial amount of power loss both in transmission and distribution. In general, distribution system has more losses than the losses occurred on the transmission side. It employs that there will be a significant difference between the generated power and the energy consumers that are (physically) far away from the generating stations. Therefore, the electric utilities always remain under stress due to such non negligible amount of losses which has a direct impact on financial management and efficiency of the power system as well. To address this issue different technique have been introduced to reduce line losses and to improve the efficiency. The best among these techniques is line loss reduction through Distributed Generation (DG) which is more effective than the other techniques. In this paper we have taken three 11kV feeders (located at Bannu) as a case study and for the prescribed technique an attempt has been made to increase the efficiency of a system by integrating different capacity of DG into a radial distribution feeder. The results have been analyzed mathematically, however Electrical Transient Analyzer Program (ETAP) simulator is used as a test bed. Finally, the obtained results are presented in tabular and graphical form in terms of clearly defined parameters.

Newcastle Disease (ND) was ranked as a List A and trade limited disease by the World Health Organization. It is one of the deadly diseases of domestic and zoo birds especially pheasants that are highly susceptible species to Newcastle disease virus (NDV). This study was designed to determine the humoral immune response (HIR) of thermostable NDV vaccine strain I-2 in same age pheasants. For this purpose, forty-five pheasants of the same age were separated and placed in cages. Thermostable NDV I-2 vaccine was mixed with feed and administered through oral route to the same age pheasants. HIR was detected using haemagglutination inhibition test (HI) and enzyme linked immunosorbent assay (ELISA) on 0, 7th, 14th, 21th and 28th days post-vaccination (DPV). Optimum geometric mean anti-NDV-ELISA (2380) and anti-NDV-HI (Log27.5) antibodies titers were identified on 14th DPV. It was concluded that the oral administration of NDV I-2 strain is able to elicit a protective immune response in pheasants. Moreover, the use of this novel vaccine technique at the same age of pheasants overwhelms the attempt to catch these birds for single vaccination.

The present study evaluated the attitude of university students and teachers towards instructional role of artificial intelligence. It was a descriptive study and the researcher used survey approach for data collection. The data was collected from 323 university students and 196 university teachers by using two questionnaires developed (one for students and one for teachers) on five point rating (Likert) scales. Descriptive statistics i.e. percentage was used for data analysis. This study demonstrated positive attitude of university students and teachers towards AI and its instructional role. It appeared to be encouraging for the respondents as well as for the administrators and policy makers. The study suggested higher education institutions to formulate a feasible policy to get benefits of instructional role of AI in higher education.

Abstract Introduction Aleutian mink disease virus (AMDV) causes a serious health problem for mink globally. The disease has no cure nor an effective vaccine and selection for tolerance using antibody titer is adopted by many mink farmers. The objective of this study was to investigate the effects of various doses of a local AMDV isolate on the response of black American mink to infection with AMDV. Methods Eight black American mink were each inoculated intranasally with 0.5 mL of eight serial 10‐fold dilutions (100 to 10−7) of a 10% spleen homogenate containing a local AMDV isolate. Blood samples were collected on days 0, 20, 35, 56, 84, 140, and 196 postinoculation (dpi). Anti‐AMDV antibodies and viral DNA were tested by counter‐immunoelectrophoresis (CIEP) and PCR, respectively. Animals that were PCR or CIEP positive at 196 dpi (n = 41) were killed at 218 dpi, and samples of blood and seven organs were tested by CIEP and PCR. Results Antibody production persisted in all seroconverted mink until the termination of the experiment, whereas 71.1% of the mink showed short‐lived viremia. Significant associations were observed between inoculum dose and the incidence of viremia until 84 dpi which disappeared thereafter, whereas associations between inoculum dose and the incidence of seropositive mink were significant on all sampling occasions. Antibody titer at 218 dpi significantly decreased with decreasing inoculum dose. AMDV DNA was detected in the bone marrow, lymph nodes, and spleen samples of almost all mink inoculated at every dose but was not detected in other organs of some mink. Conclusions CIEP is more accurate than PCR for detecting AMDV infection in mink. Using antibody titer in naturally infected mink may not be accurate for the identification of tolerant mink.

Objective: To compare the efficacy of sodium hyaluronate, hydroxypropyl methylcellulose/dextran and polypropylene/polyethylene glycol based commercial artificial tear products using the noninvasive tear film breakup time. Study Design: Quasi experimental Study. Place and Duration of Study: Study was conducted at the Eye department of Combined Military Hospital Malir Cantt Karachi, from Sep 2017 to Nov 2017. Methodology: Three different types of commercially available artificial tears were evaluated on 30 eyes of 30 patients, having all types of dry eyes diseases. The noninvasive tear film breakup time was measured before and then at 15, 30 and 45 mins after instillation of the artificial tear using keratometer. The active ingredients in these eye drops were sodium hyaluronate, polyethylene glycol/propylene glycol and hydroxypropyl methylcellulose/ dextran 70. Results: Among the three artificial tears only Sodium hyaluronate eye drops caused a statistically significant increase in noninvasive tear film break up time at 45 mins post instillation. Polyethylene glycol/propylene eye drops extended tear film breakup time upto 30 mins. Comparison of the difference in extension of the breakup time was statistically insignificant between sodium hyaluronate and polyethylene glycol/polypropylene at 15 and 30 mins post instillation. Conclusion: Sodium hyaluronate eye drops were effective in prolonging the noninvasive tear film breakup time upto 45 mins postinstillation while polypropylene/polyethylene glycol were effective upto 30 mins in all types of dry eye diseases.

Since its first report in 1942, peste-des-petits-ruminants virus (PPRV) has caused several epidemics in a wide range of susceptible hosts around the world. In the last 30 years, the evidence of natural and experimental infections and virus isolation were reported from novel but unusual hosts such as camel, cattle, buffalo, dogs, Asiatic lion and pigs. In addition, PPRV in a potential vector, biting midges (Culicoides imicola), has been reported. Either presented as clinical and/or subclinical infections, the presence of the virus in an extended range of susceptible hosts highlights the cross-species transmission and supports the hypothesis of an endemic circulation of PPRV among susceptible hosts. However, the potential role of large ruminants, camels and unusual hosts for PPRV epidemiology is still obscure. Therefore, there is a need for molecular and epidemiological investigations of the disease among usual and unusual hosts to achieve the goals of disease control and eradication programmes initiated by national and international organisations, such as the FAO and OIE. This review is the first to summarise the scattered data on PPR in large ruminants, camels and unusual hosts to obtain the global scientific communities’ attention for further research on epidemiological aspects, not only in its native hosts, but also in large ruminants, camels and other unusual hosts.

Herein, we report on the evaluation of chemically modified hyrdroxyethylcellulose for its sorption efficacy to remove Cd(II) from spiked high-hardness ground water (GW) and distilled water (DW) solutions. Hyrdroxyethylcellulose was chemically modified using adipic anhydride in the presence of DMAP as a catalyst under homogeneous reaction conditions. Hyrdroxyethylcellulose adipate (HEC-Adip) obtained was then converted to its sodium salt as HEC-Adip-Na after treating with saturated solution of NaHCO3. Structures were thoroughly characterized using FTIR, SEM, EDS and solid-state CP/MAS 13C NMR. The surface charge of the sorbent was monitored by pHZPC (pH of zero point charge). The sorption data fitted well to Langmuir isotherm and pseudo-second order kinetic model. Maximum sorption capacity of Cd(II) was calculated to be 114.94 mg g−1 and 112.35 mg g−1 from DW and GW, respectively. Thermodynamic parameters, i.e., ΔH°, ΔS° and ΔG°, were also calculated and showed negative values indicating spontaneous and exothermic nature of sorption process. In addition, the synthesized sorbent is more suitable for repeated use because it shows negligible decrease in its sorption capacity for the uptake of Cd(II) from aqueous solution after five regeneration cycles. Keywords: Hydroxyethylcellulose, Sodium hydroxyethylcellulose adipate, Metal uptake, Cadmium, Kinetics

IT exports, capital formation, FDI, and trade openness are the key elements to bring sustainable economic growth to any country, since these act as a lifeline to bring sustainability to countries. This study aims to estimate the impact of IT exports, gross capital formation, FDI, and trade openness on sustainable economic growth with regional integration of BRI countries using the annual panel data from 2013 to 2018. Moderating variable is regional integration, while the trade freedom index, investment freedom index, real interest rate, and inflation are control variables. The two-step system GMM technique is applied to the sample as the number of moment conditions is greater than the number of parameters. The results suggest that FDI and gross capital formation have a substantial positive impact on economic growth, whereas IT exports and trade openness have a negative, insignificant impact. The overall results suggest that China's outward FDI has boosted the economic growth in countries while trade openness has a negligible since most developing countries need to invest in industrialization and encourage exports based growth.

Abstract Emulsion templating is at the forefront of producing a wide array of porous materials that offers interconnected porous structure, easy permeability, homogeneous flow‐through, high diffusion rates, convective mass transfer, and direct accessibility to interact with atoms/ions/molecules throughout the exterior and interior of the bulk. These interesting features together with easily available ingredients, facile preparation methods, flexible pore‐size tuning protocols, controlled surface modification strategies, good physicochemical and dimensional stability, lightweight, convenient processing and subsequent recovery, superior pollutants remediation/monitoring performance, and decent recyclability underscore the benchmark potential of the emulsion‐templated porous materials in large‐scale practical environmental applications. To this end, many research breakthroughs in emulsion templating technique witnessed by the recent achievements have been widely unfolded and currently being extensively explored to address many of the environmental challenges. Taking into account the burgeoning progress of the emulsion‐templated porous materials in the environmental field, this review article provides a conceptual overview of emulsions and emulsion templating technique, sums up the general procedures to design and fabricate many state‐of‐the‐art emulsion‐templated porous materials, and presents a critical overview of their marked momentum in adsorption, separation, disinfection, catalysis/degradation, capture, and sensing of the inorganic, organic and biological contaminants in water and air.

Background: Tranexamic acid reduces blood loss in surgery and the risk of death in trauma patients. Meta-analyses of small trials suggest that tranexamic acid decreases the number of deaths from gastrointestinal bleeding, but these meta-analyses are prone to selection bias. Objective: The trial provides reliable evidence of the effect of tranexamic acid on mortality, rebleeding and complications in significant acute gastrointestinal bleeding. Design: A multicentre, randomised, placebo-controlled trial and economic analysis. Patients were assigned by selecting one treatment pack from a box of eight, which were identical apart from the pack number. Patients, caregivers and outcome assessors were masked to allocation. The main analyses were by intention to treat. Setting: The setting was 164 hospitals in 15 countries, co-ordinated from the London School of Hygiene & Tropical Medicine. Participants: Adults with significant upper or lower gastrointestinal bleeding (n = 12,009) were eligible if the responsible clinician was substantially uncertain about whether or not to use tranexamic acid. The clinical diagnosis of significant bleeding implied a risk of bleeding to death, including hypotension, tachycardia or signs of shock, or urgent transfusion, endoscopy or surgery. Intervention: Tranexamic acid (a 1-g loading dose over 10 minutes, then a 3-g maintenance dose over 24 hours) or matching placebo. Main outcome measures: The primary outcome was death due to bleeding within 5 days of randomisation. Secondary outcomes were all-cause and cause-specific mortality; rebleeding; need for endoscopy, surgery or radiological intervention; blood product transfusion; complications; disability; and days spent in intensive care or a high-dependency unit. Results: A total of 12,009 patients were allocated to receive tranexamic acid (n = 5994, 49.9%) or the matching placebo (n = 6015, 50.1%), of whom 11,952 (99.5%) received the first dose. Death due to bleeding within 5 days of randomisation occurred in 222 (3.7%) patients in the tranexamic acid group and in 226 (3.8%) patients in the placebo group (risk ratio 0.99, 95% confidence interval 0.82 to 1.18). Thromboembolic events occurred in 86 (1.4%) patients in the tranexamic acid group and 72 (1.2%) patients in the placebo group (risk ratio 1.20, 95% confidence interval 0.88 to 1.64). The risk of arterial thromboembolic events (myocardial infarction or stroke) was similar in both groups (0.7% in the tranexamic acid group vs. 0.8% in the placebo group; risk ratio 0.92, 95% confidence interval 0.60 to 1.39), but the risk of venous thromboembolic events (deep-vein thrombosis or pulmonary embolism) was higher in tranexamic acid-treated patients than in placebo-treated patients (0.8% vs. 0.4%; risk ratio 1.85, 95% confidence interval 1.15 to 2.98). Seizures occurred in 38 patients who received tranexamic acid and in 22 patients who received placebo (0.6% vs. 0.4%, respectively; risk ratio 1.73, 95% confidence interval 1.03 to 2.93). In the base-case economic analysis, tranexamic acid was not cost-effective and resulted in slightly poorer health outcomes than no tranexamic acid. Conclusions: Tranexamic acid did not reduce death from gastrointestinal bleeding and, although inexpensive, it is not cost-effective in adults with acute gastrointestinal bleeding. Future work: These results caution against a uniform approach to the management of patients with major haemorrhage and highlight the need for randomised trials targeted at specific pathophysiological processes. Limitations: Although this is one of the largest randomised trials in gastrointestinal bleeding, we cannot rule out a modest increase or decrease in death due to bleeding with tranexamic acid. Trial registration: Current Controlled Trials ISRCTN11225767, ClinicalTrials.gov NCT01658124 and EudraCT 2012-003192-19. Funding: This project was funded by the National Institute for Health Research (NIHR) Health Technology Assessment programme and will be published in full in Health Technology Assessment; Vol. 25, No. 58. See the NIHR Journals Library website for further project information.

The creation of novel anticancer treatments for a variety of human illnesses, including different malignancies and dangerous microbes, also potentially depends on nanoparticles including silver. Recently, it has been successful to biologically synthesize metal nanoparticles using plant extracts. The natural flavonoid 3,3′, 4′, 5,5′, and 7 hexahydroxyflavon (myricetin) has anticancer properties. There is not much known about the regulatory effects of myricetin on the possible cell fate-determination mechanisms (such as apoptosis/proliferation) in colorectal cancer. Because the majority of investigations related to the anticancer activity of myricetin have dominantly focused on the enhancement of tumor cell uncontrolled growth (i.e., apoptosis). Thus, we have decided to explore the potential myricetin interactors and the associated biological functions by using an in-silico approach. Then, we focused on the main goal of the work which involved the synthesis of silver nanoparticles and the labeling of myricetin with it. The synthesized silver nanoparticles were examined using UV-visible spectroscopy, dynamic light scattering spectroscopy, Fourier transform infrared spectroscopy, and scanning electron microscopy. In this study, we have investigated the effects of myricetin on colorectal cancer where numerous techniques were used to show myricetin’s effect on colon cancer cells. Transmission Electron Microscopy was employed to monitor morphological changes. Furthermore, we have combined the results of the colorectal cancer gene expression dataset with those of the myricetin interactors and pathways. Based on the results, we conclude that myricetin is able to efficiently kill human colorectal cancer cell lines. Since, it shares important biological roles and possible route components and this myricetin may be a promising herbal treatment for colorectal cancer as per an in-silico analysis of the TCGA dataset.

The current study is an effort to empirically assess the effect of various macroeconomic factors on inflation in Pakistan by utilizing ordinary least squares (OLS) method and Granger non-causality test in the time-series framework from 1973-Q3 to 2017-Q2. The empirical results confirm that real GDP, money supply, imports, government expenditure, and lagged inflation have a positive and considerable influence on inflation while interest rate has an adverse impact on inflation. Additionally, the findings demonstrate bidirectional causality between money supply and inflation, while the unidirectional causal relationship is found from government expenditure and imports to inflation. These results signify that inflation does not depend solely on monetary growth in Pakistan; however, imports and fiscal policy are also contributory factors that have a considerable impact on inflation. The study concludes that central authority would not accomplish the stabilize prices through changing the monetary policy until and unless the government will not fix the fiscal deficit.

Objective: To compare outcome of pterygium excision with conjunctival autograft using sutures versus conjunctival limbal autograft using autologous blood. Study Design: Randomized controlled trial. Place and Duration of Study: Combined Military Hospital (CMH) Rawalakot, from Jul 2017 to Jul 2018. Material and Methods: After getting approval from hospital ethical committee 140 patients with primary pterygium were included in the study. The demographic details were noted and patients were randomized by lottery method in two groups (group A & B). Both groups were operated under topical anesthesia (Alcain). Group A underwent lamellar pterygium excision followed by limbal conjunctival autograft secured with nylon 10/0 sutures. Group B underwent limbal conjunctival autograft using autologous blood (non-glue, suture less), 2-3 drops of patients own blood below graft acted as adhesive when left there for 15 to 20 minutes. Patients were followed up at 2 weeks, 2 month and 6 months postoperatively to see recurrence. All the readings were carried out and noted by single person in order to minimize study bias. Results: A total of 140 patients (70 in each group) were included in the study with a mean age of 32.88 ± 5.82 years in group A and 32.97 ± 4.69 years in group-B. Regarding gender distribution, 51.43% in group-A and 48.57% in group-B were males. Comparison of outcome of pterygium excision with conjunctival autograft using sutures vs conjunctival limbal autograft using autologous blood showed that 15.71% in group-A and 5.71% in group-B had recurrence of pterygium. Conclusion: We concluded that the recurrence was significantly lower after pterygium excision when comparing conjunctival limbal autograft using autologous blood (non-glue, suture less) with conjunctival autograft using sutures.

This study focused on to ascertaining the attitude of learners towards tutoring in distance education. It was a descriptive study and was delimited to B.Ed Programme of Allama Iqbal Open University (AIOU), Islamabad. Population of the study consisted of learners of B.Ed. Programme of AIOU. The sample of the study consisted on 600 learners from five Regional Campuses of AIOU in the Province of Punjab i.e. Multan, Faisalabad, Lahore, Gujranwala and Rawalpindi. The sample was drawn by using convenient-cum-purposive sampling technique(s) from five. A questionnaire was used as research tool. It was developed on 5-point rating (Likert) scale. A pilot study was conducted to finalize the tool. The finalized research tool was administered and data was collected. The data was analyzed in terms of percentage. The findings of the study demonstrated positive attitude of learners towards tutoring in distance education. It was evident from the data analysis that learners acknowledged tutors having subject knowledge and they the help them in self-study for developing new knowledge. However, learners wished feedback and comments of the tutors on their assignments in proper way. In the light of the findings of the study the researcher recommended training for distance education tutors on how to provide feedback and comments on students’ work.

Renewable CO2 conversion to useful products presents a sustainable, carbon-neutral method to limit climate change, yet few materials can perform this complex chemistry. Here, authors prepare a polymer-TiO2-graphene composite that can take up CO2 and convert it to CH4 using light and water.

Objective: The objective of the study was to determine the frequency of different pathologies presenting with lymphadenopathy in patients from South Punjab and to evaluate the role of surgery in reaching the diagnosis. Materials and Methods: It was a cross-sectional study done at Recep Tayyip Erdogan Hospital, Muzaffargarh (managed by The Indus Health Network), from August 2014 to October 2017. Those being biopsied at some other hospital and the lymph node dissection biopsy done for a known primary cancer were excluded. Results: Lymph node biopsy was done on a total of 71 patients (56.3% n = 40 males, 43.7% n = 31 females). The mean (standard deviation) age of the patients was 27.30 ± 17.07 years. Open biopsy was performed on 70 cases (98.6%), whereas laparoscopic biopsy was performed on one case (1.4%). The most common pathology found on histopathology report was Tuberclosis (TB) lymphadenitis (49.3%, n = 35), followed by lymphoma (25.4% – Hodgkin's disease [HD] 15.5% and non-Hodgkin's lymphoma [NHL] 9.9%). Conclusion: TB is the most common pathology, followed by lymphoma. HD is more common than NHL. Surgical biopsy is the gold standard. Laparoscopy and other minimally invasive techniques are very safe and useful for excision biopsy of the central lymph nodes.

Cache-enabled networks suffer hugely from the challenge of content caching and content delivery. In this regard, cache-enabled device-to-device (D2D) assisted multitier cellular networks are expected to relieve the network data pressure and effectively solve the problem of content placement and content delivery. Consequently, the user can have a better opportunity to get their favored contents from nearby cache-enabled transmitters (CETs) through reliable and good-quality links; however, as expected, designing an effective caching policy is a challenging task due to the limited cache memory of CETs and uncertainty in user preferences. In this article, we introduce a joint content placement and content delivery technique for D2D assisted multitier cellular networks (D2DMCN). A support vector machine (SVM) is employed to predict the content popularity to determine which content is to be cached and where it is to be cached, thereby increasing the overall cache hit ratio (CHR). The content request is satisfied either by the neighboring node through the D2D link or by the cache-enabled base stations (BSs) of the multitier cellular networks (MCNs). Similarly, to solve the problem of optimal content delivery, the Hungarian algorithm is employed aiming to improve the quality of satisfaction. The simulation results indicate that the proposed content placement strategy effectively optimizes the overall cache hit ratio of the system. Similarly, an effective content delivery approach reduces the request content delivery delay and power consumption.

Over the most recent couple of years, the Internet of Things and other empowering innovations have been logically utilized for digitizing the vegetable supply chain (VSC). Background: The unpredictable examples and complexity inserted in enormous data dimensions present a test for an orderly human master examination. Hence in an information-driven setting, soft computing (SC) has accomplished critical energy to investigate, mine, and concentrate confidential information data, or tackle complex improvement issues, finding some harmony between good productivity and maintainability of vegetable supply frameworks. Methods: This paper presents a new and diverse scientific classification of VSC issues from the SC methodology. It characterizes VSC issues and sorts them in light of how they be demonstrated according to the SC perspective. Moreover, we examine the SC methodologies commonly utilized in each phase of the VSC and their related classes of issues. Accordingly, there is an issue in distinguishing and characterizing VSC issues according to a more extensive point of view, enveloping the different SC strategies that can apply in various phases (from creation to retailing), and recognizing the issues that emerge in these phases according to the SC viewpoint. Results: We likewise acquaint some rules with the assistance of VSC analysts and specialists to settle on appropriate strategies while resolving specific issues they could experience. Even though a few latest examinations have arranged the SC writing in this field, they are situated towards a solitary group of SC strategies (a gathering of techniques that share standard qualities) and survey their application in VSC phases. Conclusions: We have suggested a novel approach and complete scientific classification of vegetable supply chain concerns about soft computing. We present a view of three delegate supply chains: cruciferous vegetables, dark green leafy vegetables, and tomatoes. We assembled the scientific type in light of different parts to arrange vegetable supply chain issues as per how they can be demonstrated utilizing soft computing methodologies.

Precipitation elasticity provides a basic estimate of the sensitivity of long-term streamflow to changes in long-term precipitation, and it is especially useful as the first assessment of climate change impact in land and water resource projects. This study estimated and compared the precipitation elasticity (εp) of streamflow in 86 catchments within Pakistan over 50 major rivers using three widely used analytical models: bivariate nonparametric (NP) estimator, multivariate NP analysis, and multivariate double logarithm (DL) model. All the three models gave similar values of elasticity in the range of 0.1–3.5 for over 70–75% of the catchments. This signifies that a 1% change in the annual mean precipitation compared to the long-term historic mean annual precipitation will amplify the streamflow by 0.1–3.5%. In addition, the results suggested that elasticity estimation of streamflow sensitivity using the multivariate DL model is more reliable and realistic. Precipitation elasticity of streamflow is observed high at altitudes ranging between 250 m and 1000 m while the longitudinal and latitudinal pattern of εp shows higher values in the range of 70–75 and 32–36 decimal degrees, respectively. The εp values were found to have a direct relationship with the mean annual precipitation and an inverse relationship with the catchment areas. Likewise, high εp values were noticed in areas where the mean annual temperature ranges between 15 and 24 °C.

Coronavirus Disease 2019 (COVID-19) ranks third in terms of fatal coronavirus diseases threatening public health, coming after SARS-CoV (severe acute respiratory syndrome coronavirus), and MERS-CoV (Middle East respiratory syndrome coronavirus). SARS-CoV-2 (severe acute respiratory syndrome coronavirus type 2) causes COVID-19. On January 30, 2020, the World Health Organization (WHO) announced that the current outbreak of COVID-19 is the sixth global health emergency. As of December 3, 2020, 64 million people worldwide have been affected by this malaise, and the global economy has experienced a loss of more than $1 trillion. SARS-CoV-2 is a positive-sense single-stranded RNA virus belonging to the Betacoronavirus genus. The high nucleotide sequence identity of SARS-CoV-2 with the BatCoV RaTG13 genome has indicated that bats could be the possible host of SARS-CoV-2. SARS-CoV-2 penetrates the host cell via binding its spike protein to the angiotensin-converting enzyme 2 (ACE2) receptor, which is similar to the mechanisms of SARS-CoV and MERS-CoV. COVID-19 can spread from person to person via respiratory droplets and airborne and contaminated fomites. Moreover, it poses a significant risk to smokers, the elderly, immunocompromised people, and those with preexisting comorbidities. Two main approaches are used to control viral infections, namely, vaccination, and biosecurity. Studies to analyze the antigenicity and immunogenicity of SARS-CoV-2 vaccine candidates are underway, and few vaccines may be available in the near future. In the current situation, the Human Biosecurity Emergency (HBE) may be the only way to cope effectively with the novel SARS-CoV-2 strain. Here, we summarize current knowledge on the origin of COVID-19 as well as its epidemiological relationship with humans and animals, genomic resemblance, immunopathogenesis, clinical-laboratory signs, diagnosis, control and prevention, and treatment. Moreover, we discuss the interventional effects of various nutrients on COVID-19 in detail. However, multiple possibilities are explored to fight COVID-19, and the greatest efforts targeted toward finding an effective vaccine in the near future. Furthermore, antioxidants, polyphenols, and flavonoids, both synthetic and natural, could play a crucial role in the fight against COVID-19.

Evaluation of terrestrial shale gas resource potential is a hot issue in unconventional oil and gas exploration. Organic-rich shales are widely developed in the Jurassic strata of Tarim Basin, but their shale gas potential has not been described well. In the study, the Lower-Middle Jurassic fine-grained sedimentary rocks (Kangsu and Yangye Formations) in northern Kashi Sag, northwestern Tarim Basin, were taken as the study object. The comprehensive studies include petrology, mineralogy, organic geochemistry, and physical properties, which were used to characterize the organic matter and reservoir characteristics. Results show that the Jurassic terrestrial shale in the northern Kashi Sag was mainly deposited in lakes, rivers, and deltas. The thickness of black lacustrine shale developed in the Early-Middle Jurassic in the study area is generally over 100 m. The total organic carbon (TOC) content is rich, averaging 2.77%. The vitrinite reflectance (Ro) values indicate that the Lower Jurassic shale organic matter is in the early mature–mature stage, while the Middle Jurassic is in the mature stage. Besides, organic matter is primarily II and III in kerogen types. The whole shale contains a large number of clay minerals, especially illite. The average brittle minerals such as quartz and feldspar are 28.67%, and the average brittleness index is 38.63%. Nanoscale pores containing intergranular pores, dissolution pores, and organic pores, coupled with microcracks, are well developed in Jurassic shale. The sample’s average pore volume is 0.017 cm3/g, and the specific surface area is 9.36 m2/g. Mesoporous contribute the most to pore volume, while the number of microporous is the largest. Both of them provide most of the surface area for the shale. Combined with regional geologic settings, we propose that the Jurassic terrestrial shale has good-excellent shale gas exploration potential and development prospects.

Unbalanced load condition is one of the major issues of all commercial, industrial and residential sectors. Unbalanced load means that, when different loads are distributed on a three-phase four-wire system, unequal currents pass through the three phases. Due to it, a heavy current flows in the neutral wire, which not only adds the losses, but also puts constraints on three phases’ loads. In this paper, we have presented a practical approach for load balancing. First, we have considered the existing three-phase load system where the supply is a three-phase unbalanced supply. Before balancing the load, it is necessary to compensate the current in neutral wire. A nature-inspired moth–flame optimization (MFO) algorithm is used to propose a scheme for balancing of current in neutral wire. The information of a distributed single-phase load was used to balance the currents in a three-phase system. The feeder phase and load profiles of each single-phase load are used to reconfigure the network using an optimization process. By balancing the current of three phases, the current of the neutral conductor in substation transformers was reduced to almost zero.

The Pakistan Medical and Dental Council (PM&DC) is the body concerned for the medical and dental education in Pakistan.1 The council was dissolved by an order of the President of Pakistan in October 2019, 2 but the order was revoked by the decision of the High Court of Pakistan.3 According to the PM&DC return/detention policy, a medical student has two chances of exam for his promotion in the next academic class and if one of the students could not pass the two chances provided in at least one of his subjects, the student must pass the exam in 3rd attempt with loss of his / her academic year and must pursue medical studies with the junior class. If one of these students could not pass this or these subjects by exceeding the 3rd chance, the conceded institution offers the 4th and last opportunity to the student.1 If the student still cannot pass the subject in 4th and last opportunity, he is expelled from the establishment with the cancellation of his admission, and the dreams of such a student to become a doctor are fulfilled until he will only be readmitted upon reappearing in the PM&DC competitive entrance test. But due to the sudden and unexpected outbreak of Covid-19, the medical community was the most affected. In some countries, more death rates have been reported among physicians who performed Covid-19 patient care tasks.4 Due to the lockdown policy of Govt. of Pakistan across the country, academic medical institutions were closed as a result of academic months of medical and dental students have also been wasted like other academic fields. The lockdown has been continued and we expect further academic waste from these students. The Pakistan Higher Education Commission has asked for conducting online courses for these students, but the clinical subjects of medical students cannot be taught online as they require direct clinical exposure to patients for the transmission of learning. required. Therefore, as a result of Covid-19, there is expected to be a waste of courses from almost all students across the country. However, in such circumstances, detained / term-back students will suffer a greater and irreparable waste of time as there may be many other technical difficulties regarding the continuation of medical education and the examinations of these students due to the Covid-19 disaster. Therefore, it may be good to revise the Term-Back / Detain policy for these medical, dental, and related students. The authors made the following suggestions for the PM&DC and the institutions to consider this review. 1) To Revise once the Term-Back / detention policy for the period 2019-2020 by allowing students to continue academic promotion during the next academic year with a unique relaxation in the policy. 2) Students who have not passed four chances and who are expelled from the establishment can be relaxed to have an additional chance to continue their medical studies, applicable for the year 2019-2020. 3) Relaxations are similar to those mentioned in the serial number. 1 and 2 for other courses such as Pharm-D, Bachelor of Nursing, etc. Health workers are the main force in the fight against Covid-19 in the exercise of their functions to manage the patients of Covid-19. Mortality rates among healthcare providers have also been reported due to high viral load. There may be a shortage of health care providers around the world. Therefore, facilitation attempts are necessary to help the bona fide medical profession maintain their numbers and needs in the health sectors and to meet the future needs of the world for these health workers. Consequently, in implementing the suggestions of the authors, hundreds to thousands of health professionals and paramedical services will be able to save and secure their future in the service of the sacred mission of saving and serving the sick community.