Search

Your search keyword '"Hirosue, Akiyuki"' showing total 30 results
Start Over Author "Hirosue, Akiyuki" Search Limiters Available in Library Collection
30 results on '"Hirosue, Akiyuki"'

1. FOXM1-Mediated Regulation of Reactive Oxygen Species and Radioresistance in Oral Squamous Cell Carcinoma Cells

Author

Takeshita, Hisashi, Yoshida, Ryoji, Inoue, Junki, Ishikawa, Kohei, Shinohara, Kosuke, Hirayama, Mayumi, Oyama, Toru, Kubo, Ryuta, Yamana, Keisuke, Nagao, Yuka, Gohara, Shunsuke, Sakata, Junki, Nakashima, Hikaru, Matsuoka, Yuichiro, Nakamoto, Masafumi, Hirayama, Masatoshi, Kawahara, Kenta, Takahashi, Nozomu, Hirosue, Akiyuki, Kuwahara, Yoshikazu, Fukumoto, Manabu, Toya, Ryo, Murakami, Ryuji, and Nakayama, Hideki

Published
2023
Full Text
View/download PDF

2. Naringenin potentiates anti-tumor immunity against oral cancer by inducing lymph node CD169-positive macrophage activation and cytotoxic T cell infiltration

Author

Kawaguchi, Sho, Kawahara, Kenta, Fujiwara, Yukio, Ohnishi, Koji, Pan, Cheng, Yano, Hiromu, Hirosue, Akiyuki, Nagata, Masashi, Hirayama, Masatoshi, Sakata, Junki, Nakashima, Hikaru, Arita, Hidetaka, Yamana, Keisuke, Gohara, Shunsuke, Nagao, Yuka, Maeshiro, Manabu, Iwamoto, Asuka, Hirayama, Mayumi, Yoshida, Ryoji, Komohara, Yoshihiro, and Nakayama, Hideki

Published
2022
Full Text
View/download PDF

4. Involvement of ferroptosis‐defensive xCT/GPX4 axis in radioresistance and its impacts on prognosis in oral squamous cell carcinoma

Author

Ishikawa, Kohei, primary, Matsuoka, Yuichiro, additional, Shinohara, Kosuke, additional, Inoue, Junki, additional, Yano, Hiromu, additional, Eto, Takafumi, additional, Yamamoto, Tatsuro, additional, Yamana, Keisuke, additional, Gohara, Shunsuke, additional, Takeshita, Hisashi, additional, Hirayama, Masatoshi, additional, Kawahara, Kenta, additional, Hirosue, Akiyuki, additional, Fukugawa, Yoshiyuki, additional, Yoshida, Ryoji, additional, Komohara, Yoshihiro, additional, and Nakayama, Hideki, additional

Published
2024
Full Text
View/download PDF

7. An oncolytic virus as a promising candidate for the treatment of radioresistant oral squamous cell carcinoma

Author

Gohara, Shunsuke, primary, Shinohara, Kosuke, additional, Yoshida, Ryoji, additional, Kariya, Ryusho, additional, Tazawa, Hiroshi, additional, Hashimoto, Masashi, additional, Inoue, Junki, additional, Kubo, Ryuta, additional, Nakashima, Hikaru, additional, Arita, Hidetaka, additional, Kawaguchi, Sho, additional, Yamana, Keisuke, additional, Nagao, Yuka, additional, Iwamoto, Asuka, additional, Sakata, Junki, additional, Matsuoka, Yuichiro, additional, Takeshita, Hisashi, additional, Hirayama, Masatoshi, additional, Kawahara, Kenta, additional, Nagata, Masashi, additional, Hirosue, Akiyuki, additional, Kuwahara, Yoshikazu, additional, Fukumoto, Manabu, additional, Okada, Seiji, additional, Urata, Yasuo, additional, Fujiwara, Toshiyoshi, additional, and Nakayama, Hideki, additional

Published
2022
Full Text
View/download PDF

9. Extracellular vesicles derived from radioresistant oral squamous cell carcinoma cells contribute to the acquisition of radioresistance via the miR‐503‐3p‐BAK axis

Author

Yamana, Keisuke, primary, Inoue, Junki, additional, Yoshida, Ryoji, additional, Sakata, Junki, additional, Nakashima, Hikaru, additional, Arita, Hidetaka, additional, Kawaguchi, Sho, additional, Gohara, Shunsuke, additional, Nagao, Yuka, additional, Takeshita, Hisashi, additional, Maeshiro, Manabu, additional, Liu, Rin, additional, Matsuoka, Yuichiro, additional, Hirayama, Masatoshi, additional, Kawahara, Kenta, additional, Nagata, Masashi, additional, Hirosue, Akiyuki, additional, Toya, Ryo, additional, Murakami, Ryuji, additional, Kuwahara, Yoshikazu, additional, Fukumoto, Manabu, additional, and Nakayama, Hideki, additional

Published
2021
Full Text
View/download PDF

10. miR-30a attenuates drug sensitivity to 5-FU by modulating cell proliferation possibly by downregulating cyclin E2 in oral squamous cell carcinoma

Author

Kawahara, Kenta, primary, Nagata, Masashi, additional, Yoshida, Ryoji, additional, Hirosue, Akiyuki, additional, Tanaka, Takuya, additional, Matsuoka, Yuichiro, additional, Arita, Hidetaka, additional, Nakashima, Hikaru, additional, Sakata, Junki, additional, Yamana, Keisuke, additional, Kawaguchi, Sho, additional, Gohara, Shunsuke, additional, Nagao, Yuka, additional, Hirayama, Masatoshi, additional, Takahashi, Nozomu, additional, Hirayama, Mayumi, additional, and Nakayama, Hideki, additional

Published
2021
Full Text
View/download PDF

11. Re‑evaluating the clinical significance of serum p53 antibody levels in patients with oral cancer in Japanese clinical practice

Author

Gohara, Shunsuke, primary, Yoshida, Ryoji, additional, Kawahara, Kenta, additional, Sakata, Junki, additional, Arita, Hidetaka, additional, Nakashima, Hikaru, additional, Kawaguchi, Sho, additional, Nagao, Yuka, additional, Yamana, Keisuke, additional, Nagata, Masashi, additional, Hirosue, Akiyuki, additional, Hiraki, Akimitsu, additional, and Nakayama, Hideki, additional

Published
2021
Full Text
View/download PDF

12. Onodera's prognostic nutritional index correlates with tumor immune environment and survival in patients with oral squamous cell carcinoma undergoing chemoradiotherapy

Author

Yoshida, Ryoji, primary, Gohara, Shunsuke, additional, Sakata, Junki, additional, Matsuoka, Yuichiro, additional, Hirosue, Akiyuki, additional, Kawahara, Kenta, additional, Kawaguchi, Sho, additional, Nagao, Yuka, additional, Yamana, Keisuke, additional, Nagata, Masashi, additional, Fukuma, Daiki, additional, Toya, Ryo, additional, Murakami, Ryuji, additional, Hiraki, Akimitsu, additional, Shinohara, Masanori, additional, and Nakayama, Hideki, additional

Published
2020
Full Text
View/download PDF

15. Efficacy of adjuvant chemotherapy with S-1 in stage II oral squamous cell carcinoma patients: A comparative study using the propensity score matching method

Author

Yoshida, Ryoji, primary, Nagata, Masashi, additional, Hirosue, Akiyuki, additional, Kawahara, Kenta, additional, Nakamoto, Masafumi, additional, Hirayama, Masatoshi, additional, Takahashi, Nozomu, additional, Matsuoka, Yuichiro, additional, Sakata, Junki, additional, Nakashima, Hikaru, additional, Arita, Hidetaka, additional, Hiraki, Akimitsu, additional, Shinohara, Masanori, additional, Kikuchi, Ken, additional, and Nakayama, Hideki, additional

Published
2020
Full Text
View/download PDF

16. Enhanced Expression of IGFBP-3 Reduces Radiosensitivity and Is Associated with Poor Prognosis in Oral Squamous Cell Carcinoma

Author

Sakata, Junki, primary, Hirosue, Akiyuki, additional, Yoshida, Ryoji, additional, Matsuoka, Yuichiro, additional, Kawahara, Kenta, additional, Arita, Hidetaka, additional, Nakashima, Hikaru, additional, Yamamoto, Tatsuro, additional, Nagata, Masashi, additional, Kawaguchi, Sho, additional, Gohara, Shunsuke, additional, Nagao, Yuka, additional, Yamana, Keisuke, additional, Toya, Ryo, additional, Murakami, Ryuji, additional, Kuwahara, Yoshikazu, additional, Fukumoto, Manabu, additional, and Nakayama, Hideki, additional

Published
2020
Full Text
View/download PDF

18. HMGA2 Contributes to Distant Metastasis and Poor Prognosis by Promoting Angiogenesis in Oral Squamous Cell Carcinoma

Author

Sakata, Junki, primary, Hirosue, Akiyuki, additional, Yoshida, Ryoji, additional, Kawahara, Kenta, additional, Matsuoka, Yuichiro, additional, Yamamoto, Tatsuro, additional, Nakamoto, Masafumi, additional, Hirayama, Masatoshi, additional, Takahashi, Nozomu, additional, Nakamura, Takuya, additional, Arita, Hidetaka, additional, Nakashima, Hikaru, additional, Nagata, Masashi, additional, Hiraki, Akimitsu, additional, Shinohara, Masanori, additional, and Nakayama, Hideki, additional

Published
2019
Full Text
View/download PDF

19. Circulating miRNA-1290 as a potential biomarker for response to chemoradiotherapy and prognosis of patients with advanced oral squamous cell carcinoma: A single-center retrospective study

Author

Nakashima, Hikaru, primary, Yoshida, Ryoji, additional, Hirosue, Akiyuki, additional, Kawahara, Kenta, additional, Sakata, Junki, additional, Arita, Hidetaka, additional, Yamamoto, Tatsuro, additional, Toya, Ryo, additional, Murakami, Ryuji, additional, Hiraki, Akimitsu, additional, Shinohara, Masanori, additional, Ito, Takaaki, additional, Kuwahara, Yoshikazu, additional, and Nakayama, Hideki, additional

Published
2019
Full Text
View/download PDF

20. FBXW7 expression affects the response to chemoradiotherapy and overall survival among patients with oral squamous cell carcinoma: A single-center retrospective study

Author

Arita, Hidetaka, primary, Nagata, Masashi, additional, Yoshida, Ryoji, additional, Matsuoka, Yuichiro, additional, Hirosue, Akiyuki, additional, Kawahara, Kenta, additional, Sakata, Junki, additional, Nakashima, Hikaru, additional, Kojima, Taku, additional, Toya, Ryo, additional, Murakami, Ryuji, additional, Hiraki, Akimitsu, additional, Shinohara, Masanori, additional, and Nakayama, Hideki, additional

Published
2017
Full Text
View/download PDF

22. Predictive value of the combination of SMAD4 expression and lymphocyte infiltration in malignant transformation of oral leukoplakia

Author

Sakata, Junki, primary, Yoshida, Ryoji, additional, Matsuoka, Yuichiro, additional, Nagata, Masashi, additional, Hirosue, Akiyuki, additional, Kawahara, Kenta, additional, Nakamura, Takuya, additional, Nakamoto, Masafumi, additional, Hirayama, Masatoshi, additional, Takahashi, Nozomu, additional, Nakashima, Hikaru, additional, Arita, Hidetaka, additional, Ogi, Hidenao, additional, Hiraki, Akimitsu, additional, Shinohara, Masanori, additional, and Nakayama, Hideki, additional

Published
2017
Full Text
View/download PDF

24. IL-6 controls resistance to radiation by suppressing oxidative stress via the Nrf2-antioxidant pathway in oral squamous cell carcinoma

Author

Matsuoka, Yuichiro, primary, Nakayama, Hideki, additional, Yoshida, Ryoji, additional, Hirosue, Akiyuki, additional, Nagata, Masashi, additional, Tanaka, Takuya, additional, Kawahara, Kenta, additional, Sakata, Junki, additional, Arita, Hidetaka, additional, Nakashima, Hikaru, additional, Shinriki, Satoru, additional, Fukuma, Daiki, additional, Ogi, Hidenao, additional, Hiraki, Akimitsu, additional, Shinohara, Masanori, additional, Toya, Ryo, additional, and Murakami, Ryuji, additional

Published
2016
Full Text
View/download PDF

25. Pre-treatment neutrophil to lymphocyte ratio predicts the chemoradiotherapy outcome and survival in patients with oral squamous cell carcinoma: a retrospective study

Author

Nakashima, Hikaru, primary, Matsuoka, Yuichiro, additional, Yoshida, Ryoji, additional, Nagata, Masashi, additional, Hirosue, Akiyuki, additional, Kawahara, Kenta, additional, Sakata, Junki, additional, Arita, Hidetaka, additional, Hiraki, Akimitsu, additional, and Nakayama, Hideki, additional

Published
2016
Full Text
View/download PDF

26. CTCF mediates distinct higher-order epigenetic signatures of the INK4/ARF locus in reprogrammed somatic cells

Author

Hirosue, Akiyuki

Subjects
377.5
Abstract

特定の因子を導入することで、体細胞は誘導多能性幹細胞(iPS細胞)やセネッセンス細胞にリプログラムすることができる。ヒト9番染色体に位置するINK4/ARF遺伝子座は3つの細胞周期制御因子(p15/ARF/p16)をコードし、細胞リプログラミングの重要な鍵因子であることが報告されている。しかし、この遺伝子座の高次クロマチンの制御機構については不明である。CCCTC-binding factor(CTCF)はzinc-fingerモチーフを持つタンパク質であり、転写調節、クロマチン境界形成、クロマチンループ形成などの多様な役割が判明してきた。本論文では、ヒト線維芽細胞に由来するiPS細胞、セネッセンス細胞を用いて、CTCFとp15/ARF/p16の発現様式、INK4/ARF遺伝子座の高次クロマチン構造におけるCTCFの役割を明らかにすることを目的とした。

Published
2011

27. Phase II Clinical Trial of Multiple Peptide Vaccination for Advanced Head and Neck Cancer Patients Revealed Induction of Immune Responses and Improved OS

Author

Yoshitake, Yoshihiro, primary, Fukuma, Daiki, additional, Yuno, Akira, additional, Hirayama, Masatoshi, additional, Nakayama, Hideki, additional, Tanaka, Takuya, additional, Nagata, Masashi, additional, Takamune, Yasuo, additional, Kawahara, Kenta, additional, Nakagawa, Yoshihiro, additional, Yoshida, Ryoji, additional, Hirosue, Akiyuki, additional, Ogi, Hidenao, additional, Hiraki, Akimitsu, additional, Jono, Hirofumi, additional, Hamada, Akinobu, additional, Yoshida, Koji, additional, Nishimura, Yasuharu, additional, Nakamura, Yusuke, additional, and Shinohara, Masanori, additional

Published
2015
Full Text
View/download PDF

28. Pre-treatment neutrophil to lymphocyte ratio predicts the chemoradiotherapy outcome and survival in patients with oral squamous cell carcinoma: a retrospective study.

Author

Hikaru Nakashima, Yuichiro Matsuoka, Ryoji Yoshida, Masashi Nagata, Akiyuki Hirosue, Kenta Kawahara, Junki Sakata, Hidetaka Arita, Akimitsu Hiraki, Hideki Nakayama, Nakashima, Hikaru, Matsuoka, Yuichiro, Yoshida, Ryoji, Nagata, Masashi, Hirosue, Akiyuki, Kawahara, Kenta, Sakata, Junki, Arita, Hidetaka, Hiraki, Akimitsu, and Nakayama, Hideki

Subjects
NEUTROPHILS, TREATMENT of oral cancer, SQUAMOUS cell carcinoma, LYMPHOCYTES, HEALTH outcome assessment, RETROSPECTIVE studies, CANCER chemotherapy, CANCER radiotherapy, PATIENTS, LYMPHOCYTE metabolism, C-reactive protein, FLUOROURACIL, INTERLEUKINS, MOUTH tumors, PROGNOSIS, KAPLAN-Meier estimator
Abstract

Background: The Neutrophil to lymphocyte ratio (NLR) has prognostic value in patients with a variety of cancers. However, its prognostic significance in oral squamous cell carcinoma (OSCC) patients has not been fully explored. The purpose of this study was to determine the clinical significance of NLR in patients with OSCC.Methods: OSCC patients who underwent surgery following 5-fluorouracil (5-FU)-based chemoradiotherapy were enrolled in this study. The associations between the NLR status and various clinicopathological features were examined, and the effects of the NLR on the prognosis were evaluated. Analysis of circulating interleukin-6 (IL-6) was carried out and correlation with NLR and C-reactive protein concentration (CRP) was examined.Results: An elevated NLR was significantly correlated with advanced T-stage and poor response to chemoradiotherapy. Moreover, a Cox regression analysis based on the disease-free survival (DFS) revealed the NLR status (hazard ratio, 2.013; P = 0.041) and pathological response to chemoradiotherapy (hazard ratio, 0.226; P = 0.001) to be significant prognostic factors in OSCC patients. Furthermore, circulating IL-6 was found to correlate with NLR and CRP.Conclusion: The NLR is a potential biomarker for predicting the clinical response to 5-FU-based chemoradiotherapy and the survival in OSCC patients, and the systemic inflammatory response may be potential target for improving patient's prognosis. [ABSTRACT FROM AUTHOR]

Published
2016
Full Text
View/download PDF

30. An oncolytic virus as a promising candidate for the treatment of radioresistant oral squamous cell carcinoma.

Author

Gohara S, Shinohara K, Yoshida R, Kariya R, Tazawa H, Hashimoto M, Inoue J, Kubo R, Nakashima H, Arita H, Kawaguchi S, Yamana K, Nagao Y, Iwamoto A, Sakata J, Matsuoka Y, Takeshita H, Hirayama M, Kawahara K, Nagata M, Hirosue A, Kuwahara Y, Fukumoto M, Okada S, Urata Y, Fujiwara T, and Nakayama H

Abstract

We evaluated the usefulness of an oncolytic virus (Suratadenoturev; OBP-301) against radioresistant oral squamous cell carcinoma. We confirmed the expression of human telomerase reverse transcriptase and the coxsackievirus and adenovirus receptor in cell lines. Also, we examined the potential presence in a patient who has received existing therapy that is amenable to treatment with OBP-301. We evaluated: (1) the antitumor effects of OBP-301 alone and in combination with radiotherapy on radioresistant cell lines, (2) the molecular mechanism underlying the radiosensitizing effect and cell death increased by the combination therapy, and (3) the antitumor effect of the combination therapy in vivo using xenograft models (a radioresistant cell line-derived xenograft in mouse and a patient-derived xenograft). Human telomerase reverse transcriptase and the coxsackievirus and adenovirus receptor were expressed in all cell lines. OBP-301 decreased the proliferative activity of these cell lines in a concentration-dependent manner, and significantly enhanced the antitumor effect of irradiation. Phosphorylated STAT3 and its downstream molecules, which correlated with apoptosis and autophagy, showed significant changes in expression after treatment with OBP-301. The combination therapy exerted a significant antitumor effect versus radiotherapy alone in both xenograft models. Combination of OBP-301 with radiotherapy exerts a synergistic effect and may represent a promising treatment for radioresistant oral squamous cell carcinoma., Competing Interests: The authors declare no competing interests., (© 2022 The Author(s).)

Published
2022
Full Text
View/download PDF

Catalog

Books, media, physical & digital resources
See catalog results