30 results on '"Gölz, Lina"'
Search Results
2. Influence of probiotics on the periodontium, the oral microbiota and the immune response during orthodontic treatment in adolescent and adult patients (ProMB Trial): study protocol for a prospective, double-blind, controlled, randomized clinical trial
- Author
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Seidel, Corinna L., Gerlach, Roman G., Weider, Matthias, Wölfel, Theresa, Schwarz, Vincent, Ströbel, Armin, Schmetzer, Helga, Bogdan, Christian, and Gölz, Lina
- Published
- 2022
- Full Text
- View/download PDF
3. Identification of de novo variants in nonsyndromic cleft lip with/without cleft palate patients with low polygenic risk scores
- Author
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German Research Foundation, Ishorst, Nina, Henschel, Leonie, Thieme, Frederic, Drichel, Dmitriy, Sivalingam, Sugirthan, Mehrem, Sarah L., Fechtner, Ariane C., Fazaal, Julia, Welzenbach, Julia, André Heimbach, Maj, Carlo, Hausen, Jonas, Raff, Ruth, Hoischen, Alexander, Dixon, Michael J., Rada-Iglesias, Alvaro, Bartusel, Michaela, Rojas-Martinez, Augusto, Aldhorae, Khalid, Braumann, Bert, Kruse, Teresa, Kirschnech, Christian, Spanier, Gerrit, Reutter, Heiko, Nowak, Stefanie, Gölz, Lina, Knapp, Michael, Buness, Andreas, Krawitz, Peter, Nöthen, Markus M., Nothnagel, Michael, Becker, Tim, Ludwig, Kerstin U., Mangold, Elisabeth, German Research Foundation, Ishorst, Nina, Henschel, Leonie, Thieme, Frederic, Drichel, Dmitriy, Sivalingam, Sugirthan, Mehrem, Sarah L., Fechtner, Ariane C., Fazaal, Julia, Welzenbach, Julia, André Heimbach, Maj, Carlo, Hausen, Jonas, Raff, Ruth, Hoischen, Alexander, Dixon, Michael J., Rada-Iglesias, Alvaro, Bartusel, Michaela, Rojas-Martinez, Augusto, Aldhorae, Khalid, Braumann, Bert, Kruse, Teresa, Kirschnech, Christian, Spanier, Gerrit, Reutter, Heiko, Nowak, Stefanie, Gölz, Lina, Knapp, Michael, Buness, Andreas, Krawitz, Peter, Nöthen, Markus M., Nothnagel, Michael, Becker, Tim, Ludwig, Kerstin U., and Mangold, Elisabeth
- Abstract
[Background]: Nonsyndromic cleft lip with/without cleft palate (nsCL/P) is a congenital malformation of multifactorial etiology. Research has identified >40 genome-wide significant risk loci, which explain less than 40% of nsCL/P heritability. Studies show that some of the hidden heritability is explained by rare penetrant variants. [Methods]: To identify new candidate genes, we searched for highly penetrant de novo variants (DNVs) in 50 nsCL/P patient/parent-trios with a low polygenic risk for the phenotype (discovery). We prioritized DNV-carrying candidate genes from the discovery for resequencing in independent cohorts of 1010 nsCL/P patients of diverse ethnicities and 1574 population-matched controls (replication). Segregation analyses and rare variant association in the replication cohort, in combination with additional data (genome-wide association data, expression, protein–protein-interactions), were used for final prioritization. [Conclusion]: In the discovery step, 60 DNVs were identified in 60 genes, including a variant in the established nsCL/P risk gene CDH1. Re-sequencing of 32 prioritized genes led to the identification of 373 rare, likely pathogenic variants. Finally, MDN1 and PAXIP1 were prioritized as top candidates. Our findings demonstrate that DNV detection, including polygenic risk score analysis, is a powerful tool for identifying nsCL/P candidate genes, which can also be applied to other multifactorial congenital malformations.
- Published
- 2023
4. Clinical implementation of axial angulation of incisors in the course of routine fixed appliance treatment - a retrospective cohort study
- Author
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Pour, Ramtin Davoudi, Papageorgiou, Spyridon N; https://orcid.org/0000-0003-1968-3326, Safi, Sema; https://orcid.org/0000-0002-8226-0572, Eble, Oliver-Steffen, Jäger, Andreas, Gölz, Lina, Pour, Ramtin Davoudi, Papageorgiou, Spyridon N; https://orcid.org/0000-0003-1968-3326, Safi, Sema; https://orcid.org/0000-0002-8226-0572, Eble, Oliver-Steffen, Jäger, Andreas, and Gölz, Lina
- Abstract
PURPOSE To identify clinically relevant factors for changes in axial angulation of incisors during routine fixed appliance orthodontic treatment. METHODS A total of 106 patients (grades 1-2 of IOTN, 64 females, 42 males; mean age: 15.5 years) from a private practice and treated with metal or ceramic brackets were included in this retrospective cohort study. The axial angulation of the upper and lower incisors was measured on lateral cephalograms before insertion of the first rectangular 0.016 × 0.022-in NiTi archwire (T0) and at the end of treatment about 8 weeks after insertion of the working 0.019 × 0.025-in stainless steel archwire (T1). Treatment-related changes according to bracket type, initial situation, premolar extraction, angle class, and skeletal vertical configuration were analyzed. RESULTS Although statistically significant treatment-related changes were seen for both the upper incisors (+ 1.3°) and the lower incisors (- 5.2°), only in ten patients (9.4%) was the prescribed torque value of 17° for the upper incisors and in no patient for the lower incisors achieved. A negative association between the induced change of axial angulation of incisors and the initial values was detected for the upper incisors as well as for the lower incisors. A comparison of the angle classes revealed significant differences in incisor changes. At the end of therapy, only a slight change for the upper central incisors in patients in angle class I cases and a significantly greater change in patients with angle class II/2 was observed. Cases with premolar extraction ended with lower axial angulation of the incisor than cases without extraction. The individual analysis of possible influencing factors also revealed an association with the vertical skeletal configuration. CONCLUSIONS For the first time, the presented data show clinically relevant influencing factors for incisor axial angulation changes of the upper and lower incisors in relation to the torque value of the applie
- Published
- 2023
5. Genome-wide transcriptome induced by nickel in human monocytes
- Author
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Gölz, Lina, Buerfent, Benedikt C., Hofmann, Andrea, Rühl, Heiko, Fricker, Nadine, Stamminger, Wiebke, Oldenburg, Johannes, Deschner, James, Hoerauf, Achim, Nöthen, Markus M., Schumacher, Johannes, Hübner, Marc P., and Jäger, Andreas
- Published
- 2016
- Full Text
- View/download PDF
6. Orofacial clefts alter early life oral microbiome maturation towards higher levels of potentially pathogenic species: A prospective observational study
- Author
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Seidel, Corinna L., primary, Strobel, Karin, additional, Weider, Matthias, additional, Tschaftari, Marco, additional, Unertl, Christoph, additional, Willershausen, Ines, additional, Weber, Manuel, additional, Hoerning, André, additional, Morhart, Patrick, additional, Schneider, Michael, additional, Beckmann, Matthias W., additional, Bogdan, Christian, additional, Gerlach, Roman G., additional, and Gölz, Lina, additional
- Published
- 2023
- Full Text
- View/download PDF
7. Identification of de novo variants in nonsyndromic cleft lip with/without cleft palate patients with low polygenic risk scores
- Author
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Ishorst, Nina, primary, Henschel, Leonie, additional, Thieme, Frederic, additional, Drichel, Dmitriy, additional, Sivalingam, Sugirthan, additional, Mehrem, Sarah L., additional, Fechtner, Ariane C., additional, Fazaal, Julia, additional, Welzenbach, Julia, additional, Heimbach, André, additional, Maj, Carlo, additional, Borisov, Oleg, additional, Hausen, Jonas, additional, Raff, Ruth, additional, Hoischen, Alexander, additional, Dixon, Michael, additional, Rada‐Iglesias, Alvaro, additional, Bartusel, Michaela, additional, Rojas‐Martinez, Augusto, additional, Aldhorae, Khalid, additional, Braumann, Bert, additional, Kruse, Teresa, additional, Kirschneck, Christian, additional, Spanier, Gerrit, additional, Reutter, Heiko, additional, Nowak, Stefanie, additional, Gölz, Lina, additional, Knapp, Michael, additional, Buness, Andreas, additional, Krawitz, Peter, additional, Nöthen, Markus M., additional, Nothnagel, Michael, additional, Becker, Tim, additional, Ludwig, Kerstin U., additional, and Mangold, Elisabeth, additional
- Published
- 2022
- Full Text
- View/download PDF
8. Orofacial clefts lead to increased pro-inflammatory cytokine levels on neonatal oral mucosa
- Author
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Seidel, Corinna L., primary, Percivalle, Elena, additional, Tschaftari, Marco, additional, Weider, Matthias, additional, Strobel, Karin, additional, Willershausen, Ines, additional, Unertl, Christoph, additional, Schmetzer, Helga M., additional, Weber, Manuel, additional, Schneider, Michael, additional, Frey, Benjamin, additional, Gaipl, Udo S., additional, Beckmann, Matthias W., additional, and Gölz, Lina, additional
- Published
- 2022
- Full Text
- View/download PDF
9. Congenital Nail Disorders among Children with Suspected Ectodermal Dysplasias
- Author
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Maier-Wohlfart, Sigrun, primary, Aicher, Carmen, additional, Willershausen, Ines, additional, Peschel, Nicolai, additional, Meißner, Udo, additional, Gölz, Lina, additional, and Schneider, Holm, additional
- Published
- 2022
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- View/download PDF
10. Imputation of orofacial clefting data identifies novel risk loci and sheds light on the genetic background of cleft lip ± cleft palate and cleft palate only
- Author
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Ludwig, Kerstin U., Böhmer, Anne C., Bowes, John, Nikolić, Miloš, Ishorst, Nina, Wyatt, Niki, Hammond, Nigel L., Gölz, Lina, Thieme, Frederic, Barth, Sandra, Schuenke, Hannah, Klamt, Johanna, Spielmann, Malte, Aldhorae, Khalid, Rojas-Martinez, Augusto, Nöthen, Markus M., Rada-Iglesias, Alvaro, Dixon, Michael J., Knapp, Michael, and Mangold, Elisabeth
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- 2017
- Full Text
- View/download PDF
11. Local Vascularization during Orthodontic Tooth Movement in a Split Mouth Rat Model—A MRI Study
- Author
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Proff, Peter, Schröder, Agnes, Seyler, Lisa, Wolf, Franziska, Korkmaz, Yüksel, Bäuerle, Tobias, Gölz, Lina, and Kirschneck, Christian
- Subjects
stomatognathic diseases ,ddc:610 ,lcsh:Biology (General) ,vascularization ,stomatognathic system ,RECEPTOR ACTIVATOR ,HPDL CELLS ,EXPRESSION ,TISSUE ,VEGF ,magnetic resonance imaging ,orthodontic tooth movement ,610 Medizin ,lcsh:QH301-705.5 - Abstract
Orthodontic tooth movement to therapeutically align malpositioned teeth is supposed to impact blood flow in the surrounding tissues. Here, we evaluated actual vascularization in the tension area of the periodontal ligament during experimental tooth movement in rats (N = 8) with magnetic resonance imaging (MRI). We inserted an elastic band between the left upper first and the second rat molar, the right side was not treated and served as control. After four days of tooth movement, we recorded T1-weighted morphologic and dynamic-contrast-enhanced MRI sequences with an animal-specific 7 Tesla MRI to assess of local vascularization. Furthermore, we quantified osteoclasts and monocytes in the periodontal ligament, which are crucial for orthodontic tooth movement, root resorptions as undesirable side effects, as well as the extent of tooth movement using paraffine histology and micro-CT analysis. Data were tested for normal distribution with Shapiro&ndash, Wilk tests followed by either a two-tailed paired t-test or a Wilcoxon matched-pairs signed rank test. Significant orthodontic tooth movement was induced within the four days of treatment, as evidenced by increased osteoclast and monocyte activity in the periodontal ligament as well as by µ, CT analysis. Contrast enhancement was increased at the orthodontically-treated side distally of the moved upper first left molar, indicating increased vascularization at the tension side of the periodontal ligament. Accordingly, we detected reduced time-to-peak and washout rates. Our study using MRI to directly assess local vascularization thus seems to confirm the hypothesis that perfusion is enhanced in tension zones of the periodontal ligament during orthodontic tooth movement.
- Published
- 2020
12. Defining Metaniches in the Oral Cavity According to Their Microbial Composition and Cytokine Profile
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Seidel, Corinna L., Gerlach, Roman G., Wiedemann, Patrick, Weider, Matthias, Rodrian, Gabriele, Hader, Michael, Frey, Benjamin, Gaipl, Udo S., Bozec, Aline, Cieplik, Fabian, Kirschneck, Christian, Bogdan, Christian, and Gölz, Lina
- Subjects
Adult ,DNA, Bacterial ,Male ,multiplex immunoassay ,oral niches ,cytokine profile ,Article ,lcsh:Chemistry ,Young Adult ,Tongue ,oral biofilms and fluids ,RNA, Ribosomal, 16S ,Humans ,ddc:610 ,Saliva ,lcsh:QH301-705.5 ,Mouth ,Palate ,Microbiota ,Gingival Crevicular Fluid ,oral microbiota ,metaniches ,stomatognathic diseases ,lcsh:Biology (General) ,lcsh:QD1-999 ,Cytokines ,next-generation sequencing ,Female - Abstract
The human oral microbiota consists of over 700 widespread taxa colonizing the oral cavity in several anatomically diverse oral niches. Lately, sequencing of the 16S rRNA genes has become an acknowledged, culture-independent method to characterize the oral microbiota. However, only a small amount of data are available concerning microbial differences between oral niches in periodontal health and disease. In the context of periodontitis, the cytokine expression in the gingival crevicular fluid has been studied in detail, whereas little is known about the cytokine profile in hard and soft tissue biofilms. In order to characterize oral niches in periodontal health, the oral microbiota and cytokine pattern were analyzed at seven different sites (plaque (P), gingival crevicular fluid (GCF), saliva (S), tongue (T), hard palate (HP), cheek (C) and sublingual area (U)) of 20 young adults using next-generation sequencing and multiplex immunoassays. Site-specific microbial compositions were detected, which clustered into three distinct metaniches (&ldquo, P-GCF&rdquo, &ldquo, S-T-HP&rdquo, and &ldquo, C-U&rdquo, ) and were associated with niche-/metaniche-specific cytokine profiles. Our findings allow the definition of distinct metaniches according to their microbial composition, partly reflected by their cytokine profile, and provide new insights into microenvironmental similarities between anatomical diverse oral niches.
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- 2020
13. Cephalometry without complex dedicated postprocessing in an oriented magnetic resonance imaging dataset: a pilot study
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März, Karoline, primary, Chepura, Taras, additional, Plewig, Blanka, additional, Haddad, Daniel, additional, Weber, Daniel, additional, Schmid, Matthias, additional, Hirschfelder, Ursula, additional, and Gölz, Lina, additional
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- 2021
- Full Text
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14. Role of Oxygen Supply in Macrophages in a Model of Simulated Orthodontic Tooth Movement
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Schröder, Agnes, Barschkies, Leonie, Jantsch, Jonathan, Proff, Peter, Gölz, Lina, Deschner, James, and Kirschneck, Christian
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Vascular Endothelial Growth Factor A ,ddc:610 ,DNA, Complementary ,Article Subject ,Interleukin-6 ,Tumor Necrosis Factor-alpha ,Macrophages ,Immunoblotting ,610 Medizin ,Enzyme-Linked Immunosorbent Assay ,Real-Time Polymerase Chain Reaction ,Cell Hypoxia ,Mice ,RAW 264.7 Cells ,Pathology ,Animals ,RB1-214 ,Research Article - Abstract
Apart from periodontal ligament fibroblasts, immune cells like macrophages also play an important mediating role in orthodontic tooth movement (OTM). Upon orthodontic force application to malpositioned teeth, macrophages in the periodontal ligament get exposed to both mechanical strain and hypoxic conditions (via a compression of blood vessels). In this study, we assessed the relative impact of orthodontically induced mechanical strain and hypoxic conditions on macrophages for the mediation and regulation of OTM. Macrophages were stimulated with physiological orthodontic compressive forces of 2 g/cm(2) for 4 h and 24 h on gas-impermeable or gas-permeable cell culture plates under normoxic or hypoxic cell culture conditions. We quantified expression of genes involved in inflammation (Tnf,Il-6, andCox-2), extracellular remodelling (Mmp-9), and angiogenesis (Vegf) by RT-qPCR. Furthermore, we analysed HIF-1 alpha, prostaglandin-E2, and VEGF protein expression via immunoblotting or ELISA. Mechanical strain and oxygen supply both differentially affected expression of genes and proteins involved in inflammation and angiogenesis. In this context, we found that HIF-1 alpha protein levels were elevated by combined mechanical strain and hypoxic conditions, whereas gas-permeable plates providing sufficient oxygen supply prevented HIF-1 alpha stabilization at the protein level after pressure application on macrophages. Our results thus indicate that macrophages involved in the mediation of OTM are affected by and respond differently to hypoxic conditions and mechanical compressive strain, which occur concomitantly during OTM, than periodontal ligament fibroblasts (PDLF), thus indicating different roles of these cells in the regulation of OTM at the cellular-molecular level. We further observed that contrary to PDLF HIF-1 alpha stabilization in macrophages is rather induced via the decreased oxygen supply associated with OTM than via mechanotransduction by mechanical strain.
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- 2020
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15. The Special Developmental Biology of Craniofacial Tissues Enables the Understanding of Oral and Maxillofacial Physiology and Diseases
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Weber, Manuel, primary, Wehrhan, Falk, additional, Deschner, James, additional, Sander, Janina, additional, Ries, Jutta, additional, Möst, Tobias, additional, Bozec, Aline, additional, Gölz, Lina, additional, Kesting, Marco, additional, and Lutz, Rainer, additional
- Published
- 2021
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16. Inflammation in the Human Periodontium Induces Downregulation of the α1- and β1-Subunits of the sGC in Cementoclasts
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Korkmaz, Yüksel, primary, Puladi, Behrus, additional, Galler, Kerstin, additional, Kämmerer, Peer W., additional, Schröder, Agnes, additional, Gölz, Lina, additional, Sparwasser, Tim, additional, Bloch, Wilhelm, additional, Friebe, Andreas, additional, and Deschner, James, additional
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- 2021
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17. Influence of Natural Killer Cells and Natural Killer T Cells on Periodontal Disease: A Systematic Review of the Current Literature
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Seidel, Andreas, primary, Seidel, Corinna L., additional, Weider, Matthias, additional, Junker, Rüdiger, additional, Gölz, Lina, additional, and Schmetzer, Helga, additional
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- 2020
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- View/download PDF
18. Local Vascularization during Orthodontic Tooth Movement in a Split Mouth Rat Model—A MRI Study
- Author
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Proff, Peter, primary, Schröder, Agnes, additional, Seyler, Lisa, additional, Wolf, Franziska, additional, Korkmaz, Yüksel, additional, Bäuerle, Tobias, additional, Gölz, Lina, additional, and Kirschneck, Christian, additional
- Published
- 2020
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19. A Human Periodontal Ligament Fibroblast Cell Line as a New Model to Study Periodontal Stress
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Weider, Matthias, primary, Schröder, Agnes, additional, Docheva, Denitsa, additional, Rodrian, Gabriele, additional, Enderle, Isabel, additional, Seidel, Corinna Lesley, additional, Andreev, Darja, additional, Wegner, Michael, additional, Bozec, Aline, additional, Deschner, James, additional, Kirschneck, Christian, additional, Proff, Peter, additional, and Gölz, Lina, additional
- Published
- 2020
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20. Clinical retention force development of double crowns
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Bayer, Stefan, Stark, Helmut, Gölz, Lina, Keilig, Ludger, Kraus, Dominik, Hansen, Anja, Enkling, Norbert, Bayer, Stefan, Stark, Helmut, Gölz, Lina, Keilig, Ludger, Kraus, Dominik, Hansen, Anja, and Enkling, Norbert
- Abstract
This study deals with the development of the retentive forces of double crowns intraorally measured. Twenty-five combined fixed-removable prostheses with a total of 84 double crowns were included in the study. The intraoral measurement was performed at 72 defined measuring points directly adjacent to the double crowns of the dentures. The measurement was performed 4-6weeks (baseline), 6months (recall 1), and 18months (recall 2) after the insertion of the restoration. A specifically designed measuring device was used. The median values for the single measuring points reached 4.705N at the baseline, 5.190N after 6months, and 3.740N after 18months. The measured values were analyzed according to differences between the median retention forces at the three defined points in time. The statistical analysis of the median values showed no statistical difference for the retention force change after 6months but for the decrease until the second recall (Mann-Whitney test). The retention force per denture was calculated by a summation of the single measuring points. At the baseline, 12.9N was reached. The forces did only decrease slightly and were not statistically significant. The results indicate that retention force values of double crowns, measured intraorally at the patient, do not relevantly change clinically within the first 1.5years. Within the limitations of this study, it can be stated that wear does not influence the retentive forces of double crowns within the first 18months. After this period the retention force should be still sufficient for denture retention
- Published
- 2018
21. Effectiveness of early orthopaedic treatment with headgear: a systematic review and meta-analysis
- Author
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Papageorgiou, Spyridon N; https://orcid.org/0000-0003-1968-3326, Kutschera, Eric, Memmert, Svenja, Gölz, Lina, Jäger, Andreas, Bourauel, Christoph, Eliades, Theodore, Papageorgiou, Spyridon N; https://orcid.org/0000-0003-1968-3326, Kutschera, Eric, Memmert, Svenja, Gölz, Lina, Jäger, Andreas, Bourauel, Christoph, and Eliades, Theodore
- Abstract
BACKGROUND Although the headgear appliance has been used extensively to correct anteroposterior discrepancies, its treatment effects have not yet been adequately assessed in an evidence-based manner. OBJECTIVE Aim of this systematic review was to assess the therapeutic and adverse effects of early headgear treatment from controlled clinical trials on human patients in an evidence-based manner. SEARCH METHODS An unrestricted electronic search of six databases from inception to December 2015. SELECTION CRITERIA Randomized and prospective non-randomized controlled trials assessing the effects of headgear treatment on human patients. DATA COLLECTION AND ANALYSIS After duplicate study selection, data extraction, and risk of bias assessment according to the Cochrane guidelines, random-effects meta-analyses of mean differences (MDs) and relative risks (RRs), including their 95% confidence intervals (CIs) were performed, followed by subgroup and sensitivity analyses. RESULTS A total of 18 unique studies with a total of 930 (56% male/44% female) patients were included. Headgear treatment was associated with a posterior translation of the anterior maxilla border in the short term, as seen by the mean annualized change in the SNA angle (MD = -1.63°/year; 95% CI = -2.20 to -1.06°/year; high quality evidence) compared to untreated patients. This effect was independent of the rotation of the palatal plane and the inclination of the upper incisors, while a proportional relationship with the initial discrepancy in SNA was seen. The clinical significance of this improvement diminished in the long term, although only limited evidence existed. Additionally, early headgear treatment might decrease the risk of dental trauma during the following years (RR = 0.34; 95% CI = 0.14 to 0.80; moderate quality evidence). Low quality evidence on the effect of headgear on the rotation of the palatal plane, the nasolabial angle, the occlusal outcome, and signs of temporomandibular disorders preclud
- Published
- 2017
22. Lingual vs. labial fixed orthodontic appliances: systematic review and meta-analysis of treatment effects
- Author
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Papageorgiou, Spyridon N; https://orcid.org/0000-0003-1968-3326, Gölz, Lina, Jäger, Andreas, Eliades, Theodore, Bourauel, Christoph, Papageorgiou, Spyridon N; https://orcid.org/0000-0003-1968-3326, Gölz, Lina, Jäger, Andreas, Eliades, Theodore, and Bourauel, Christoph
- Abstract
The aim of this systematic review was to compare the therapeutic and adverse effects of lingual and labial orthodontic fixed appliances from clinical trials on human patients in an evidence-based manner. Randomized and prospective non-randomized clinical trials comparing lingual and labial appliances were included. Risk of bias within and across studies was assessed using the Cochrane tool and the Grading of Recommendations Assessment, Development and Evaluation (GRADE) approach. Random-effects meta-analyses were conducted, followed by subgroup and sensitivity analyses. Six electronic databases were searched from inception to July 2015, without limitations. A total of 13 papers pertaining to 11 clinical trials were included with a total of 407 (34% male/66% female) patients. Compared with labial appliances, lingual appliances were associated with increased overall oral discomfort, increased speech impediment (measured using auditory analysis), worse speech performance assessed by laypersons, increased eating difficulty, and decreased intermolar width. On the other hand, lingual appliances were associated with increased intercanine width and significantly decreased anchorage loss of the maxillary first molar during space closure. Based on existing trials, there is insufficient evidence to make robust recommendations for lingual fixed orthodontic appliances regarding their therapeutic or adverse effects, as the quality of evidence was low.
- Published
- 2016
23. Effectiveness of early orthopaedic treatment with headgear: a systematic review and meta-analysis
- Author
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Papageorgiou, Spyridon N., primary, Kutschera, Eric, additional, Memmert, Svenja, additional, Gölz, Lina, additional, Jäger, Andreas, additional, Bourauel, Christoph, additional, and Eliades, Theodore, additional
- Published
- 2016
- Full Text
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24. Sequencing the GRHL3 Coding Region Reveals Rare Truncating Mutations and a Common Susceptibility Variant for Nonsyndromic Cleft Palate
- Author
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Mangold, Elisabeth, primary, Böhmer, Anne C., additional, Ishorst, Nina, additional, Hoebel, Ann-Kathrin, additional, Gültepe, Pinar, additional, Schuenke, Hannah, additional, Klamt, Johanna, additional, Hofmann, Andrea, additional, Gölz, Lina, additional, Raff, Ruth, additional, Tessmann, Peter, additional, Nowak, Stefanie, additional, Reutter, Heiko, additional, Hemprich, Alexander, additional, Kreusch, Thomas, additional, Kramer, Franz-Josef, additional, Braumann, Bert, additional, Reich, Rudolf, additional, Schmidt, Gül, additional, Jäger, Andreas, additional, Reiter, Rudolf, additional, Brosch, Sibylle, additional, Stavusis, Janis, additional, Ishida, Miho, additional, Seselgyte, Rimante, additional, Moore, Gudrun E., additional, Nöthen, Markus M., additional, Borck, Guntram, additional, Aldhorae, Khalid A., additional, Lace, Baiba, additional, Stanier, Philip, additional, Knapp, Michael, additional, and Ludwig, Kerstin U., additional
- Published
- 2016
- Full Text
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25. Effectiveness of early orthopaedic treatment with headgear: a systematic review and meta-analysis.
- Author
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Papageorgiou, Spyridon N., Kutschera, Eric, Memmert, Svenja, Gölz, Lina, Jäger, Andreas, Bourauel, Christoph, and Eliades, Theodore
- Subjects
ORTHODONTIC appliances, Removable ,ORTHODONTICS ,TEETH abnormalities ,TOOTH care & hygiene ,META-analysis ,CLINICAL trials - Abstract
Background: Although the headgear appliance has been used extensively to correct anteroposterior discrepancies, its treatment effects have not yet been adequately assessed in an evidence-based manner. Objective: Aim of this systematic review was to assess the therapeutic and adverse effects of early headgear treatment from controlled clinical trials on human patients in an evidence-based manner. Search methods: An unrestricted electronic search of six databases from inception to December 2015. Selection criteria: Randomized and prospective non-randomized controlled trials assessing the effects of headgear treatment on human patients. Data collection and analysis: After duplicate study selection, data extraction, and risk of bias assessment according to the Cochrane guidelines, random-effects meta-analyses of mean differences (MDs) and relative risks (RRs), including their 95% confidence intervals (CIs) were performed, followed by subgroup and sensitivity analyses. Results: A total of 18 unique studies with a total of 930 (56% male/44% female) patients were included. Headgear treatment was associated with a posterior translation of the anterior maxilla border in the short term, as seen by the mean annualized change in the SNA angle (MD = -1.63°/ year; 95% CI = -2.20 to -1.06°/year; high quality evidence) compared to untreated patients. This effect was independent of the rotation of the palatal plane and the inclination of the upper incisors, while a proportional relationship with the initial discrepancy in SNA was seen. The clinical significance of this improvement diminished in the long term, although only limited evidence existed. Additionally, early headgear treatment might decrease the risk of dental trauma during the following years (RR = 0.34; 95% CI = 0.14 to 0.80; moderate quality evidence). Low quality evidence on the effect of headgear on the rotation of the palatal plane, the nasolabial angle, the occlusal outcome, and signs of temporomandibular disorders precluded robust assessments, due to risk of bias, inconsistency, imprecision, and small-study effects. Conclusions: Based on existing trials, headgear is a viable treatment option to modify sagittal growth of the maxilla in the short term in Class II patients with maxillary prognathism. [ABSTRACT FROM AUTHOR]
- Published
- 2017
- Full Text
- View/download PDF
26. Wear of double crown systems: electroplated vs. casted female part
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Bayer, Stefan, primary, Kraus, Dominik, additional, Keilig, Ludger, additional, Gölz, Lina, additional, Stark, Helmut, additional, and Enkling, Norbert, additional
- Published
- 2012
- Full Text
- View/download PDF
27. Inflammation in the Human Periodontium Induces Downregulation of the α 1 - and β 1 -Subunits of the sGC in Cementoclasts.
- Author
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Korkmaz, Yüksel, Puladi, Behrus, Galler, Kerstin, Kämmerer, Peer W., Schröder, Agnes, Gölz, Lina, Sparwasser, Tim, Bloch, Wilhelm, Friebe, Andreas, and Deschner, James
- Subjects
PERIODONTITIS ,CYCLIC guanylic acid ,OSTEOCLASTS ,GUANYLATE cyclase ,CEMENTUM ,OSTEOCLAST inhibition ,PROTEIN expression - Abstract
Nitric oxide (NO) binds to soluble guanylyl cyclase (sGC), activates it in a reduced oxidized heme iron state, and generates cyclic Guanosine Monophosphate (cGMP), which results in vasodilatation and inhibition of osteoclast activity. In inflammation, sGC is oxidized and becomes insensitive to NO. NO- and heme-independent activation of sGC requires protein expression of the α
1 - and β1 -subunits. Inflammation of the periodontium induces the resorption of cementum by cementoclasts and the resorption of the alveolar bone by osteoclasts, which can lead to tooth loss. As the presence of sGC in cementoclasts is unknown, we investigated the α1 - and β1 -subunits of sGC in cementoclasts of healthy and inflamed human periodontium using double immunostaining for CD68 and cathepsin K and compared the findings with those of osteoclasts from the same sections. In comparison to cementoclasts in the healthy periodontium, cementoclasts under inflammatory conditions showed a decreased staining intensity for both α1 - and β1 -subunits of sGC, indicating reduced protein expression of these subunits. Therefore, pharmacological activation of sGC in inflamed periodontal tissues in an NO- and heme-independent manner could be considered as a new treatment strategy to inhibit cementum resorption. [ABSTRACT FROM AUTHOR]- Published
- 2021
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28. Clinical retention force development of double crowns
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Bayer, Stefan, Stark, Helmut, Gölz, Lina, Keilig, Ludger, Kraus, Dominik, Hansen, Anja, Enkling, Norbert, Bayer, Stefan, Stark, Helmut, Gölz, Lina, Keilig, Ludger, Kraus, Dominik, Hansen, Anja, and Enkling, Norbert
- Abstract
This study deals with the development of the retentive forces of double crowns intraorally measured. Twenty-five combined fixed-removable prostheses with a total of 84 double crowns were included in the study. The intraoral measurement was performed at 72 defined measuring points directly adjacent to the double crowns of the dentures. The measurement was performed 4-6weeks (baseline), 6months (recall 1), and 18months (recall 2) after the insertion of the restoration. A specifically designed measuring device was used. The median values for the single measuring points reached 4.705N at the baseline, 5.190N after 6months, and 3.740N after 18months. The measured values were analyzed according to differences between the median retention forces at the three defined points in time. The statistical analysis of the median values showed no statistical difference for the retention force change after 6months but for the decrease until the second recall (Mann-Whitney test). The retention force per denture was calculated by a summation of the single measuring points. At the baseline, 12.9N was reached. The forces did only decrease slightly and were not statistically significant. The results indicate that retention force values of double crowns, measured intraorally at the patient, do not relevantly change clinically within the first 1.5years. Within the limitations of this study, it can be stated that wear does not influence the retentive forces of double crowns within the first 18months. After this period the retention force should be still sufficient for denture retention
29. Influence of time after extraction on the development of gingival invagination: study protocol for a multicenter pilot randomized controlled clinical trial.
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Reichert, Christoph, Kutschera, Eric, Nienkemper, Manuel, Scharf, Sven, Mengel, Martin, Fimmers, Rolf, Fuhrmann, Christine, Plötz, Christina, Gölz, Lina, Drescher, Dieter, Braumann, Bert, and Jäger, Andreas
- Abstract
Background: Gingival invaginations are a common side effect of orthodontic therapy involving tooth extraction and subsequent space closure. Consequences of gingival invaginations are a jeopardized stability of the space closure and hampered oral hygiene. In a retrospective study, the factor time until initiation of orthodontic space closure after tooth extraction has been identified as a potential risk factor for the development of gingival invaginations. The aim of this pilot study is to proof this hypothesis and to enable a caseload calculation for further clinical trials. The referring question is: is it possible to reduce the number of developing gingival invaginations by initiation of orthodontic space closure after tooth extraction at an early point of time?Design: The intended pilot study is designed as a multicenter randomized controlled clinical trial, comparing the impact of two different time intervals from tooth extraction to initiation of orthodontic space closure on the development of gingival invaginations.Forty participants, men and women in the age range of 11 to 30 years with orthodontically related indication for tooth extraction in the lower jaw, will be randomized 1:1 in one of two treatment groups. In group A the orthodontic tooth movement into the extraction area will be initiated in a time interval 2 to 4 weeks after tooth extraction. In group B the tooth movement will be initiated in a time interval >12 weeks after extraction. A possible effect of these treatment modalities on the development of gingival invaginations will be documented at the moment of space closure or 10 months +/- 14 days after initiation of space closure respectively, by clinical documentation of the primary (reduced number of gingival invagination) and the secondary endpoint (reduction of the severity of gingival invaginations).Trial Registration: Universal Trial Number U1111-1132-6655; German Clinical Trials Register DRKS00004248. [ABSTRACT FROM AUTHOR]- Published
- 2013
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30. Identification of de novo variants in nonsyndromic cleft lip with/without cleft palate patients with low polygenic risk scores.
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Ishorst N, Henschel L, Thieme F, Drichel D, Sivalingam S, Mehrem SL, Fechtner AC, Fazaal J, Welzenbach J, Heimbach A, Maj C, Borisov O, Hausen J, Raff R, Hoischen A, Dixon M, Rada-Iglesias A, Bartusel M, Rojas-Martinez A, Aldhorae K, Braumann B, Kruse T, Kirschneck C, Spanier G, Reutter H, Nowak S, Gölz L, Knapp M, Buness A, Krawitz P, Nöthen MM, Nothnagel M, Becker T, Ludwig KU, and Mangold E
- Subjects
- Humans, Genome-Wide Association Study, DNA-Binding Proteins genetics, Risk Factors, Cleft Palate genetics, Cleft Lip genetics
- Abstract
Background: Nonsyndromic cleft lip with/without cleft palate (nsCL/P) is a congenital malformation of multifactorial etiology. Research has identified >40 genome-wide significant risk loci, which explain less than 40% of nsCL/P heritability. Studies show that some of the hidden heritability is explained by rare penetrant variants., Methods: To identify new candidate genes, we searched for highly penetrant de novo variants (DNVs) in 50 nsCL/P patient/parent-trios with a low polygenic risk for the phenotype (discovery). We prioritized DNV-carrying candidate genes from the discovery for resequencing in independent cohorts of 1010 nsCL/P patients of diverse ethnicities and 1574 population-matched controls (replication). Segregation analyses and rare variant association in the replication cohort, in combination with additional data (genome-wide association data, expression, protein-protein-interactions), were used for final prioritization., Conclusion: In the discovery step, 60 DNVs were identified in 60 genes, including a variant in the established nsCL/P risk gene CDH1. Re-sequencing of 32 prioritized genes led to the identification of 373 rare, likely pathogenic variants. Finally, MDN1 and PAXIP1 were prioritized as top candidates. Our findings demonstrate that DNV detection, including polygenic risk score analysis, is a powerful tool for identifying nsCL/P candidate genes, which can also be applied to other multifactorial congenital malformations., (© 2022 The Authors. Molecular Genetics & Genomic Medicine published by Wiley Periodicals LLC.)
- Published
- 2023
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