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1. The IAHS Science for Solutions decade, with Hydrology Engaging Local People IN a Global world (HELPING)

Author

Arheimer, B., Cudennec, C., Castellarin, A., Grimaldi, S., Heal, K.V., Lupton, C., Sarkar, A., Tian, F., Kileshye Onema, J.-M., Archfield, S., Blöschl, G., Borges Chaffe, P.L., Croke, B.F.W., Dembélé, M., Leong, C., Mijic, A., Mosquera, G.M., Nlend, B., OIusola, A.O., Polo, M.J., Sandells, M., Sheffield, J., van Hateren, T.C., Shafiei, M., Adla, S., Agarwal, A., Aguilar, C., Andersson, J.C.M., Andraos, C., Andreu, A., Avanzi, F., Bart, R.R., Bartosova, A., Batelaan, O., Bennett, J.C., Bertola, M., Bezak, N., Boekee, J., Bogaard, T., Booij, M.J., Brigode, P., Buytaert, W., Bziava, K., Castelli, G., Castro, C.V., Ceperley, N.C., Chidepudi, S.K.R., Chiew, F.H.S., Chun, K.P., Dagnew, A.G., Dekongmen, B.W., del Jesus, M., Dezetter, A., do Nascimento Batista, J.A., Doble, R.C., Dogulu, N., Eekhout, J.P.C., Elçi, A., Elenius, M., Finger, D.C., Fiori, A., Fischer, S., Förster, K., Ganora, D., Gargouri Ellouze, E., Ghoreishi, M., Harvey, N., Hrachowitz, M., Jampani, M., Jaramillo, F., Jongen, H.J., Kareem, K.Y., Khan, U.T., Khatami, S., Kingston, D.G., Koren, G., Krause, S., Kreibich, H., Lerat, J., Liu, J., de Brito, Mariana Madruga, Mahé, G., Makurira, H., Mazzoglio, P., Nabavi, E., Nkwasa, A., Orduna Alegria, M.E., Orieschnig, C., Ovcharuk, V., Palmate, S.S., Pande, S., Pandey, S., Papacharalampous, G., Pechlivanidis, I., Penny, G., Pimentel, R., Post, D.A., Prieto, C., Razavi, S., Salazar-Galán, S., Arheimer, B., Cudennec, C., Castellarin, A., Grimaldi, S., Heal, K.V., Lupton, C., Sarkar, A., Tian, F., Kileshye Onema, J.-M., Archfield, S., Blöschl, G., Borges Chaffe, P.L., Croke, B.F.W., Dembélé, M., Leong, C., Mijic, A., Mosquera, G.M., Nlend, B., OIusola, A.O., Polo, M.J., Sandells, M., Sheffield, J., van Hateren, T.C., Shafiei, M., Adla, S., Agarwal, A., Aguilar, C., Andersson, J.C.M., Andraos, C., Andreu, A., Avanzi, F., Bart, R.R., Bartosova, A., Batelaan, O., Bennett, J.C., Bertola, M., Bezak, N., Boekee, J., Bogaard, T., Booij, M.J., Brigode, P., Buytaert, W., Bziava, K., Castelli, G., Castro, C.V., Ceperley, N.C., Chidepudi, S.K.R., Chiew, F.H.S., Chun, K.P., Dagnew, A.G., Dekongmen, B.W., del Jesus, M., Dezetter, A., do Nascimento Batista, J.A., Doble, R.C., Dogulu, N., Eekhout, J.P.C., Elçi, A., Elenius, M., Finger, D.C., Fiori, A., Fischer, S., Förster, K., Ganora, D., Gargouri Ellouze, E., Ghoreishi, M., Harvey, N., Hrachowitz, M., Jampani, M., Jaramillo, F., Jongen, H.J., Kareem, K.Y., Khan, U.T., Khatami, S., Kingston, D.G., Koren, G., Krause, S., Kreibich, H., Lerat, J., Liu, J., de Brito, Mariana Madruga, Mahé, G., Makurira, H., Mazzoglio, P., Nabavi, E., Nkwasa, A., Orduna Alegria, M.E., Orieschnig, C., Ovcharuk, V., Palmate, S.S., Pande, S., Pandey, S., Papacharalampous, G., Pechlivanidis, I., Penny, G., Pimentel, R., Post, D.A., Prieto, C., Razavi, S., and Salazar-Galán, S.

Abstract

The new scientific decade (2023-2032) of the International Association of Hydrological Sciences (IAHS) aims at searching for sustainable solutions to undesired water conditions - may it be too little, too much or too polluted. Many of the current issues originate from global change, while solutions to problems must embrace local understanding and context. The decade will explore the current water crises by searching for actionable knowledge within three themes: global and local interactions, sustainable solutions and innovative cross-cutting methods. We capitalise on previous IAHS Scientific Decades shaping a trilogy; from Hydrological Predictions (PUB) to Change and Interdisciplinarity (Panta Rhei) to Solutions (HELPING). The vision is to solve fundamental water-related environmental and societal problems by engaging with other disciplines and local stakeholders. The decade endorses mutual learning and co-creation to progress towards UN sustainable development goals. Hence, HELPING is a vehicle for putting science in action, driven by scientists working on local hydrology in coordination with local, regional, and global processes.

Published
2024

2. Effects of losartan and atorvastatin on the development of early posttraumatic joint stiffness in a rat model

Author

Baranowski A, Schlemmer L, Förster K, Slotina E, Mickan T, Truffel S, Klein A, Mattyasovszky SG, Hofmann A, Ritz U, and Rommens PM

Subjects
posttraumatic joint stiffness, knee joint contracture, rat model, myofibroblast, antifibrotic drugs, bone sialoprotein, Therapeutics. Pharmacology, RM1-950
Abstract

Andreas Baranowski,1 Ludwig Schlemmer,1 Katharina Förster,1 Ekaterina Slotina,1 Tim Mickan,1 Sebastian Truffel,1 Anja Klein,1 Stefan G Mattyasovszky,1 Alexander Hofmann,1,2 Ulrike Ritz,1 Pol M Rommens11Department of Orthopaedics and Traumatology, Biomatics Group, University Medical Centre of the Johannes Gutenberg University, Mainz, Germany; 2Department of Traumatology and Orthopaedics 1, Westpfalz-Medical Centre Kaiserslautern, Kaiserslautern, GermanyBackground: After a trauma, exuberant tissue healing with fibrosis of the joint capsule can lead to posttraumatic joint stiffness (PTJS). Losartan and atorvastatin have both shown their antifibrotic effects in different organ systems.Objective: The purpose of this study was the evaluation of the influence of losartan and atorvastatin on the early development of joint contracture. In addition to joint angles, the change in myofibroblast numbers and the distribution of bone sialoprotein (BSP) were assessed.Study design and methods: In this randomized and blinded experimental study with 24 rats, losartan and atorvastatin were compared to a placebo. After an initial joint injury, rat knees were immobilized with a Kirschner wire. Rats received either losartan, atorvastatin or a placebo orally daily. After 14 days, joint angle measurements and histological assessments were performed.Results: Losartan increased the length of the inferior joint capsule. Joint angle and other capsule length measurements did not reveal significant differences between both drugs and the placebo. At cellular level both losartan and atorvastatin reduced the total number of myofibroblasts (losartan: 191±77, atorvastatin: 98±58, placebo: 319±113 per counting field, p

Published
2019

4. In vivo hippocampal subfield volumes in bipolar disorder—A mega-analysis from The Enhancing Neuro Imaging Genetics through Meta-Analysis Bipolar Disorder Working Group

Author

Haukvik, UK, Gurholt, TP, Nerland, S, Elvsåshagen, T, Akudjedu, TN, Alda, M, Alnæs, D, Alonso-Lana, S, Bauer, J, Baune, BT, Benedetti, F, Berk, Michael, Bettella, F, Bøen, E, Bonnín, CM, Brambilla, P, Canales-Rodríguez, EJ, Cannon, DM, Caseras, X, Dandash, O, Dannlowski, U, Delvecchio, G, Díaz-Zuluaga, AM, van Erp, TGM, Fatjó-Vilas, M, Foley, SF, Förster, K, Fullerton, JM, Goikolea, JM, Grotegerd, D, Gruber, O, Haarman, BCM, Haatveit, B, Hajek, T, Hallahan, B, Harris, M, Hawkins, EL, Howells, FM, Hülsmann, C, Jahanshad, N, Jørgensen, KN, Kircher, T, Krämer, B, Krug, A, Kuplicki, R, Lagerberg, TV, Lancaster, TM, Lenroot, RK, Lonning, V, López-Jaramillo, C, Malt, UF, McDonald, C, McIntosh, AM, McPhilemy, G, van der Meer, D, Melle, I, Melloni, EMT, Mitchell, PB, Nabulsi, L, Nenadić, I, Oertel, V, Oldani, L, Opel, N, Otaduy, MCG, Overs, BJ, Pineda-Zapata, JA, Pomarol-Clotet, E, Radua, J, Rauer, L, Redlich, R, Repple, J, Rive, MM, Roberts, G, Ruhe, HG, Salminen, LE, Salvador, R, Sarró, S, Savitz, J, Schene, AH, Sim, K, Soeiro-de-Souza, MG, Stäblein, M, Stein, DJ, Stein, F, Tamnes, CK, Temmingh, HS, Thomopoulos, SI, Veltman, DJ, Vieta, E, Waltemate, L, Westlye, LT, Whalley, HC, Sämann, PG, Thompson, PM, Ching, CRK, Andreassen, OA, Agartz, I, Haukvik, UK, Gurholt, TP, Nerland, S, Elvsåshagen, T, Akudjedu, TN, Alda, M, Alnæs, D, Alonso-Lana, S, Bauer, J, Baune, BT, Benedetti, F, Berk, Michael, Bettella, F, Bøen, E, Bonnín, CM, Brambilla, P, Canales-Rodríguez, EJ, Cannon, DM, Caseras, X, Dandash, O, Dannlowski, U, Delvecchio, G, Díaz-Zuluaga, AM, van Erp, TGM, Fatjó-Vilas, M, Foley, SF, Förster, K, Fullerton, JM, Goikolea, JM, Grotegerd, D, Gruber, O, Haarman, BCM, Haatveit, B, Hajek, T, Hallahan, B, Harris, M, Hawkins, EL, Howells, FM, Hülsmann, C, Jahanshad, N, Jørgensen, KN, Kircher, T, Krämer, B, Krug, A, Kuplicki, R, Lagerberg, TV, Lancaster, TM, Lenroot, RK, Lonning, V, López-Jaramillo, C, Malt, UF, McDonald, C, McIntosh, AM, McPhilemy, G, van der Meer, D, Melle, I, Melloni, EMT, Mitchell, PB, Nabulsi, L, Nenadić, I, Oertel, V, Oldani, L, Opel, N, Otaduy, MCG, Overs, BJ, Pineda-Zapata, JA, Pomarol-Clotet, E, Radua, J, Rauer, L, Redlich, R, Repple, J, Rive, MM, Roberts, G, Ruhe, HG, Salminen, LE, Salvador, R, Sarró, S, Savitz, J, Schene, AH, Sim, K, Soeiro-de-Souza, MG, Stäblein, M, Stein, DJ, Stein, F, Tamnes, CK, Temmingh, HS, Thomopoulos, SI, Veltman, DJ, Vieta, E, Waltemate, L, Westlye, LT, Whalley, HC, Sämann, PG, Thompson, PM, Ching, CRK, Andreassen, OA, and Agartz, I

Published
2022

5. Reproducibility in the absence of selective reporting: An illustration from large-scale brain asymmetry research

Author

Kong, XZ, Francks, C, Mathias, SR, Guadalupe, T, Abé, C, Agartz, I, Akudjedu, TN, Aleman, A, Alhusaini, S, Allen, NB, Ames, D, Andreassen, OA, Vasquez, AA, Armstrong, NJ, Asherson, P, Bergo, F, Bastin, ME, Batalla, A, Bauer, J, Baune, BT, Baur-Streubel, R, Biederman, J, Blaine, SK, Boedhoe, P, Bøen, E, Bose, A, Bralten, J, Brandeis, D, Brem, S, Brodaty, H, Yüksel, D, Brooks, SJ, Buitelaar, J, Bürger, C, Bülow, R, Calhoun, V, Calvo, A, Canales-Rodríguez, EJ, Cannon, DM, Caparelli, EC, Castellanos, FX, Cendes, F, Chaim-Avancini, TM, Chantiluke, K, Chen, QL, Chen, X, Cheng, Y, Christakou, A, Clark, VP, Coghill, D, Connolly, CG, Conzelmann, A, Córdova-Palomera, A, Cousijn, J, Crow, T, Cubillo, A, Dannlowski, U, de Bruttopilo, SA, de Zeeuw, P, Deary, IJ, Demeter, DV, Di Martino, A, Dickie, EW, Dietsche, B, Doan, NT, Doherty, CP, Doyle, A, Durston, S, Earl, E, Ehrlich, S, Ekman, CJ, Elvsåshagen, T, Epstein, JN, Fair, DA, Faraone, SV, Fernández, G, Flint, C, Filho, GB, Förster, K, Fouche, JP, Foxe, JJ, Frodl, T, Fuentes-Claramonte, P, Fullerton, JM, Garavan, H, do Santos Garcia, D, Gotlib, IH, Goudriaan, AE, Grabe, HJ, Groenewold, NA, Grotegerd, D, Gruber, O, Gurholt, T, Haavik, J, Hahn, T, Hansell, NK, Harris, MA, Hartman, CA, del Carmen Valdés Hernández, M, Kong, XZ, Francks, C, Mathias, SR, Guadalupe, T, Abé, C, Agartz, I, Akudjedu, TN, Aleman, A, Alhusaini, S, Allen, NB, Ames, D, Andreassen, OA, Vasquez, AA, Armstrong, NJ, Asherson, P, Bergo, F, Bastin, ME, Batalla, A, Bauer, J, Baune, BT, Baur-Streubel, R, Biederman, J, Blaine, SK, Boedhoe, P, Bøen, E, Bose, A, Bralten, J, Brandeis, D, Brem, S, Brodaty, H, Yüksel, D, Brooks, SJ, Buitelaar, J, Bürger, C, Bülow, R, Calhoun, V, Calvo, A, Canales-Rodríguez, EJ, Cannon, DM, Caparelli, EC, Castellanos, FX, Cendes, F, Chaim-Avancini, TM, Chantiluke, K, Chen, QL, Chen, X, Cheng, Y, Christakou, A, Clark, VP, Coghill, D, Connolly, CG, Conzelmann, A, Córdova-Palomera, A, Cousijn, J, Crow, T, Cubillo, A, Dannlowski, U, de Bruttopilo, SA, de Zeeuw, P, Deary, IJ, Demeter, DV, Di Martino, A, Dickie, EW, Dietsche, B, Doan, NT, Doherty, CP, Doyle, A, Durston, S, Earl, E, Ehrlich, S, Ekman, CJ, Elvsåshagen, T, Epstein, JN, Fair, DA, Faraone, SV, Fernández, G, Flint, C, Filho, GB, Förster, K, Fouche, JP, Foxe, JJ, Frodl, T, Fuentes-Claramonte, P, Fullerton, JM, Garavan, H, do Santos Garcia, D, Gotlib, IH, Goudriaan, AE, Grabe, HJ, Groenewold, NA, Grotegerd, D, Gruber, O, Gurholt, T, Haavik, J, Hahn, T, Hansell, NK, Harris, MA, Hartman, CA, and del Carmen Valdés Hernández, M

Published
2022

6. In vivo hippocampal subfield volumes in bipolar disorder-A mega-analysis from The Enhancing Neuro Imaging Genetics through Meta-Analysis Bipolar Disorder Working Group

Author

Haukvik, U.K., Gurholt, T.P., Nerland, S., Elvsåshagen, T., Akudjedu, T.N., Alda, M., Alnaes, D., Alonso-Lana, S., Bauer, J., Baune, B.T., Benedetti, F. De, Berk, M., Bettella, F., Bøen, E., Bonnín, C.M., Brambilla, P., Canales-Rodríguez, E.J., Cannon, D.M., Caseras, X., Dandash, O., Dannlowski, U., Delvecchio, G., Díaz-Zuluaga, A.M., Erp, T.G. van, Fatjó-Vilas, M., Foley, S.F., Förster, K., Fullerton, J.M., Goikolea, J.M., Grotegerd, D., Gruber, O., Haarman, B.C.M., Haatveit, B., Hajek, T., Hallahan, B., Harris, M., Hawkins, E.L., Howells, F.M., Hülsmann, C., Jahanshad, N., Jørgensen, K.N., Kircher, T., Krämer, B., Krug, A., Kuplicki, R., Lagerberg, T.V., Lancaster, T.M., Lenroot, R.K., Lonning, V., López-Jaramillo, C., Malt, U.F., McDonald, C., McIntosh, A.M., McPhilemy, G., Meer, D. van der, Melle, I., Melloni, E.M.T., Mitchell, P.B., Nabulsi, L., Nenadić, I., Oertel, V., Oldani, L., Opel, N., Otaduy, M.C.G., Overs, B.J., Pineda-Zapata, J.A., Pomarol-Clotet, E., Radua, J., Rauer, L., Redlich, R., Repple, J., Rive, M.M., Roberts, G., Ruhe, H.G., Salminen, L.E., Salvador, R., Sarró, S., Savitz, J., Schene, A.H., Sim, K., Soeiro-de-Souza, M.G., Stäblein, M., Stein, D.J., Stein, F., Tamnes, C.K., Temmingh, H.S., Thomopoulos, S.I., Veltman, D.J., Vieta, E., Waltemate, L., Westlye, L.T., Whalley, H.C., Sämann, P.G., Thompson, P.M., Ching, C.R., Andreassen, O.A., Agartz, I., Haukvik, U.K., Gurholt, T.P., Nerland, S., Elvsåshagen, T., Akudjedu, T.N., Alda, M., Alnaes, D., Alonso-Lana, S., Bauer, J., Baune, B.T., Benedetti, F. De, Berk, M., Bettella, F., Bøen, E., Bonnín, C.M., Brambilla, P., Canales-Rodríguez, E.J., Cannon, D.M., Caseras, X., Dandash, O., Dannlowski, U., Delvecchio, G., Díaz-Zuluaga, A.M., Erp, T.G. van, Fatjó-Vilas, M., Foley, S.F., Förster, K., Fullerton, J.M., Goikolea, J.M., Grotegerd, D., Gruber, O., Haarman, B.C.M., Haatveit, B., Hajek, T., Hallahan, B., Harris, M., Hawkins, E.L., Howells, F.M., Hülsmann, C., Jahanshad, N., Jørgensen, K.N., Kircher, T., Krämer, B., Krug, A., Kuplicki, R., Lagerberg, T.V., Lancaster, T.M., Lenroot, R.K., Lonning, V., López-Jaramillo, C., Malt, U.F., McDonald, C., McIntosh, A.M., McPhilemy, G., Meer, D. van der, Melle, I., Melloni, E.M.T., Mitchell, P.B., Nabulsi, L., Nenadić, I., Oertel, V., Oldani, L., Opel, N., Otaduy, M.C.G., Overs, B.J., Pineda-Zapata, J.A., Pomarol-Clotet, E., Radua, J., Rauer, L., Redlich, R., Repple, J., Rive, M.M., Roberts, G., Ruhe, H.G., Salminen, L.E., Salvador, R., Sarró, S., Savitz, J., Schene, A.H., Sim, K., Soeiro-de-Souza, M.G., Stäblein, M., Stein, D.J., Stein, F., Tamnes, C.K., Temmingh, H.S., Thomopoulos, S.I., Veltman, D.J., Vieta, E., Waltemate, L., Westlye, L.T., Whalley, H.C., Sämann, P.G., Thompson, P.M., Ching, C.R., Andreassen, O.A., and Agartz, I.

Abstract

Contains fulltext : 252169.pdf (Publisher’s version ) (Open Access), The hippocampus consists of anatomically and functionally distinct subfields that may be differentially involved in the pathophysiology of bipolar disorder (BD). Here we, the Enhancing NeuroImaging Genetics through Meta-Analysis Bipolar Disorder workinggroup, study hippocampal subfield volumetry in BD. T1-weighted magnetic resonance imaging scans from 4,698 individuals (BD = 1,472, healthy controls [HC] = 3,226) from 23 sites worldwide were processed with FreeSurfer. We used linear mixed-effects models and mega-analysis to investigate differences in hippocampal subfield volumes between BD and HC, followed by analyses of clinical characteristics and medication use. BD showed significantly smaller volumes of the whole hippocampus (Cohen's d = -0.20), cornu ammonis (CA)1 (d = -0.18), CA2/3 (d = -0.11), CA4 (d = -0.19), molecular layer (d = -0.21), granule cell layer of dentate gyrus (d = -0.21), hippocampal tail (d = -0.10), subiculum (d = -0.15), presubiculum (d = -0.18), and hippocampal amygdala transition area (d = -0.17) compared to HC. Lithium users did not show volume differences compared to HC, while non-users did. Antipsychotics or antiepileptic use was associated with smaller volumes. In this largest study of hippocampal subfields in BD to date, we show widespread reductions in nine of 12 subfields studied. The associations were modulated by medication use and specifically the lack of differences between lithium users and HC supports a possible protective role of lithium in BD.

Published
2022

7. Correction to: Biological sex classification with structural MRI data shows increased misclassification in transgender women.

Author

Flint, C, Förster, K, Koser, SA, Konrad, C, Zwitserlood, P, Berger, K, Hermesdorf, M, Kircher, T, Nenadic, I, Krug, A, Baune, BT, Dohm, K, Redlich, R, Opel, N, Arolt, V, Hahn, T, Jiang, X, Dannlowski, U, Grotegerd, D, Flint, C, Förster, K, Koser, SA, Konrad, C, Zwitserlood, P, Berger, K, Hermesdorf, M, Kircher, T, Nenadic, I, Krug, A, Baune, BT, Dohm, K, Redlich, R, Opel, N, Arolt, V, Hahn, T, Jiang, X, Dannlowski, U, and Grotegerd, D

Published
2022

10. Früherkennung wissenschaftlicher Konvergenz im Hochschulmanagement

Author

Melnychuk, T., Galke, L., Seidlmayer, E., Förster, K., Tochtermann, K., and Schultz, C.

Abstract

It is crucial for universities to recognize early signals of scientific convergence. Scientific convergence describes a dynamic pattern where the distance between different fields of knowledge shrinks over time. This knowledge space is beneficial to radical innovations and new promising research topics. Research in converging areas of knowledge can therefore allow universities to establish a leading position in the science community. The Q-AKTIV project develops a new approach on the basis of machine learning to identify scientific convergence at an early stage. In this work, we briefly present this approach and the first results of empirical validation. We discuss the benefits of an instrument building on our approach for the strategic management of universities and other research institutes.

Published
2021

12. Comparison of partial roasting and alkaline sulfide leaching for treatment of As-rich concentrates

Author

Meiner, K., Weigelt, A., Charitos, A., Stelter, M., Wrobel, M., Förster, K., Hammerschmidt, J., Parra, R., Bachmann, K., Buchmann, M., Meiner, K., Weigelt, A., Charitos, A., Stelter, M., Wrobel, M., Förster, K., Hammerschmidt, J., Parra, R., Bachmann, K., and Buchmann, M.

Abstract

Copper possesses a variety of applications. With regard to the primary copper production, enriched sulfidic copper concentrates are fed to the smelters. Within the last decades the copper concentration in usable ores/concentrates is decreasing. Concentrate content in impurities like arsenic, antimony, bismuth and other hazardous elements, which are mineralogically bonded, is on the rise. In addition to the state of the art partial roasting process, the removal of arsenic through alkaline sulfide leaching of respective copper concentrates is a viable option. Mineralogical and chemical compositions of arsenic-bearing concentrates are measured by PXRD, XRF and AES. The particle based mineralogy of examine concentrates is characterized by MLA. Moreover, fluid bed roasting and under nitrogen/oxygen atmosphere are conducted to examine operational parameters on arsenic removal with focus on the oxygen partial pressure. For the hydrometallurgical part leaching tests with a sulfide solution under alkaline conditions are conducted in a lab scale reactor allowing for direct process comparison.

Published
2021

13. Brain structural correlates of alexithymia in patients with major depressive disorder

Author

Förster, K. (Katharina), Enneking, V. (Verena), Dohm, K. (Katharina), Redlich, R. (Ronny), Meinert, S. (Susanne), Geisler, A.I. (Adina), Leehr, E.J. (Elisabeth), Kugel, H. (Harald), Baune, B.T. (Bernhard), Arolt, V. (Volker), Zwitserlood, P. (Pienie), Grotegerd, D. (Dominik), Dannlowski, U. (Udo), and Universitäts- und Landesbibliothek Münster

Subjects
Medicine and health, ddc:610, behavioral disciplines and activities
Abstract

BACKGROUND: Alexithymia is a risk factor for major depressive disorder (MDD) and has been associated with diminished treatment response. Neuroimaging studies have revealed structural aberrations of the anterior cingulate cortex and the fusiform gyrus in healthy controls with high levels of alexithymia. The present study tried to corroborate and extend these results to patients with MDD compared with healthy controls. METHODS: We investigated the relationship between alexithymia, depression and grey matter volume in 63 patients with MDD (mean age ± standard deviation = 42.43 yr ± 11.91; 33 female) and 46 healthy controls (45.35 yr ± 8.37; 22 female). We assessed alexithymia using the Toronto Alexithymia Scale. We conducted an alexithymia × group analysis of covariance; we used a region-of-interest approach, including the fusiform gyrus and anterior cingulate cortex, and conducted whole brain analysis using voxelbased morphometry. RESULTS: Our analysis revealed a significant alexithymia × group interaction in the fusiform gyrus (left, pFWE = 0.031; right, pFWE = 0.010). Higher alexithymia scores were associated with decreased grey matter volume in patients with MDD (pFWE = 0.009), but with increased grey matter volume of the fusiform gyrus in healthy controls (pFWE = 0.044). We found no significant main effects in the region-of-interest analysis. LIMITATIONS: Owing to the naturalistic nature of our study, patients with MDD and healthy controls differed significantly in their alexithymia scores. CONCLUSION: Our results showed the fusiform gyrus as a correlate of alexithymia. We also found differences related to alexithymia between patients with MDD and healthy controls in the fusiform gyrus. Our study encourages research related to the transition from risk to MDD in people with alexithymia.

Published
2020

19. Mapping cortical brain asymmetry in 17,141 healthy individuals worldwide via the ENIGMA consortium

Author

Kong, XZ, Mathias, SR, Guadalupe, T, Abé, C, Agartz, I, Akudjedu, TN, Aleman, A, Alhusaini, S, Allen, NB, Ames, D, Andreassen, OA, Vasquez, AA, Armstrong, NJ, Bergo, F, Bastin, ME, Batalla, A, Bauer, J, Baune, BT, Baur-Streubel, R, Biederman, J, Blaine, SK, Boedhoe, P, Bøen, E, Bose, A, Bralten, J, Brandeis, D, Brem, S, Brodaty, H, Yüksel, D, Brooks, SJ, Buitelaar, J, Bürger, C, Bülow, R, Calhoun, V, Calvo, A, Canales-Rodríguez, EJ, Canive, JM, Cannon, DM, Caparelli, EC, Castellanos, FX, Cavalleri, GL, Cendes, F, Chaim-Avancini, TM, Chantiluke, K, Chen, QL, Chen, X, Cheng, Y, Christakou, A, Clark, VP, Coghill, D, Connolly, CG, Conzelmann, A, Córdova-Palomera, A, Cousijn, J, Crow, T, Cubillo, A, Dale, A, Dannlowski, U, De Bruttopilo, SA, De Zeeuw, P, Deary, IJ, Delanty, N, Demeter, DV, Di Martino, A, Dickie, EW, Dietsche, B, Doan, NT, Doherty, CP, Doyle, A, Durston, S, Earl, E, Ehrlich, S, Ekman, CJ, Elvsåshagen, T, Epstein, JN, Fair, DA, Faraone, SV, Fernández, G, Filho, GB, Förster, K, Fouche, JP, Foxe, JJ, Frodl, T, Fuentes-Claramonte, P, Fullerton, J, Garavan, H, Garcia, DDS, Gotlib, IH, Goudriaan, AE, Grabe, HJ, Groenewold, NA, Grotegerd, D, Gruber, O, Gurholt, T, Haavik, J, Hahn, T, Hansell, NK, Harris, MA, Hartman, CA, Hernández, MDCV, Kong, XZ, Mathias, SR, Guadalupe, T, Abé, C, Agartz, I, Akudjedu, TN, Aleman, A, Alhusaini, S, Allen, NB, Ames, D, Andreassen, OA, Vasquez, AA, Armstrong, NJ, Bergo, F, Bastin, ME, Batalla, A, Bauer, J, Baune, BT, Baur-Streubel, R, Biederman, J, Blaine, SK, Boedhoe, P, Bøen, E, Bose, A, Bralten, J, Brandeis, D, Brem, S, Brodaty, H, Yüksel, D, Brooks, SJ, Buitelaar, J, Bürger, C, Bülow, R, Calhoun, V, Calvo, A, Canales-Rodríguez, EJ, Canive, JM, Cannon, DM, Caparelli, EC, Castellanos, FX, Cavalleri, GL, Cendes, F, Chaim-Avancini, TM, Chantiluke, K, Chen, QL, Chen, X, Cheng, Y, Christakou, A, Clark, VP, Coghill, D, Connolly, CG, Conzelmann, A, Córdova-Palomera, A, Cousijn, J, Crow, T, Cubillo, A, Dale, A, Dannlowski, U, De Bruttopilo, SA, De Zeeuw, P, Deary, IJ, Delanty, N, Demeter, DV, Di Martino, A, Dickie, EW, Dietsche, B, Doan, NT, Doherty, CP, Doyle, A, Durston, S, Earl, E, Ehrlich, S, Ekman, CJ, Elvsåshagen, T, Epstein, JN, Fair, DA, Faraone, SV, Fernández, G, Filho, GB, Förster, K, Fouche, JP, Foxe, JJ, Frodl, T, Fuentes-Claramonte, P, Fullerton, J, Garavan, H, Garcia, DDS, Gotlib, IH, Goudriaan, AE, Grabe, HJ, Groenewold, NA, Grotegerd, D, Gruber, O, Gurholt, T, Haavik, J, Hahn, T, Hansell, NK, Harris, MA, Hartman, CA, and Hernández, MDCV

Abstract

Hemispheric asymmetry is a cardinal feature of human brain organization. Altered brain asymmetry has also been linked to some cognitive and neuropsychiatric disorders. Here, the ENIGMA (Enhancing NeuroImaging Genetics through Meta-Analysis) Consortium presents the largest-ever analysis of cerebral cortical asymmetry and its variability across individuals. Cortical thickness and surface area were assessed in MRI scans of 17,141 healthy individuals from 99 datasets worldwide. Results revealed widespread asymmetries at both hemispheric and regional levels, with a generally thicker cortex but smaller surface area in the left hemisphere relative to the right. Regionally, asymmetries of cortical thickness and/or surface area were found in the inferior frontal gyrus, transverse temporal gyrus, parahippocampal gyrus, and entorhinal cortex. These regions are involved in lateralized functions, including language and visuospatial processing. In addition to population-level asymmetries, variability in brain asymmetry was related to sex, age, and intracranial volume. Interestingly, we did not find significant associations between asymmetries and handedness. Finally, with two independent pedigree datasets (n = 1,443 and 1,113, respectively), we found several asymmetries showing significant, replicable heritability. The structural asymmetries identified and their variabilities and heritability provide a reference resource for future studies on the genetic basis of brain asymmetry and altered laterality in cognitive, neurological, and psychiatric disorders.

Published
2018

23. Klimafolgenabschätzungen in der Wasserwirtschaft und deren Nutzen für die Praxis

Author

Petry, U., Anhalt, M., Berndt, C., Fangmann, A., Förster, K., Gelleszun, M., Haberlandt, U., Hölscher, J., Kreye, P., Meon, G., Meyer, S., Müller, H., Deutsche Meteorologische Gesellschaft, and KlimaCampus Hamburg

Subjects
Ingenieurwissenschaften (620)
Abstract

Klimafolgen Climate Impacts Der globale Klimawandel kann regional unterschiedliche Auswirkungen haben. Während sich die wissenschaftliche Forschung vor allem mit der Analyse der Daten beschäftigt, ist die fachliche Praxis darum bemüht, die Ergebnisse zu interpretieren und Handlungsempfehlungen daraus abzuleiten. Im Zuge des Projektes KliBiW (Globaler Klimawandel – Wasserwirtschaftliche Folgenabschätzung für das Binnenland) wurden die Auswirkungen des Klimawandels auf die Hochwasser- und Niedrigwasserverhältnisse in Niedersachsen untersucht. Hierzu wurden die Daten von zwei regionalen Klimamodellen (WETTREG2006 und REMO), beide angetrieben durch das Globalmodell ECHAM5/MPI-OM, räumlich interpoliert und die Niederschläge zum Teil zeitlich disaggregiert, um hoch aufgelöste Klimainformationen bereitzuhalten. Anschließend erfolgte die Kopplung mit einem hydrologischen Modellsystem (PANTA RHEI), das bereits in der Hochwasservorhersagezentrale des NLWKN im Einsatz ist. Über Langzeitsimulationen wurden zukünftige Veränderungen in den Abflussverhältnissen räumlich und zeitlich differenziert für das Aller-Leine Gebiet identifiziert. Als Betrachtungszeiträume dienten eine nahe Zukunftsphase (2021 – 2050) und eine ferne Zukunftsphase (2071 – 2100). Die Veränderungen verschiedener hydrologischer Hoch- und Niedrigwasser-Kenngrößen wurden gegenüber einem Kontrollzeitraum (1971 – 2000) aufgezeigt. Die Auswertungen an 8 Pegeln in Einzugsgebieten >1.000 km² auf Tageswertbasis und an 6 Pegeln in Einzugsgebieten

Published
2015

25. TNF receptors 1 and 2 exert distinct region-specific effects on striatal and hippocampal grey matter volumes (VBM) in healthy adults

Author

Stacey, D., primary, Redlich, R., additional, Büschel, A., additional, Opel, N., additional, Grotegerd, D., additional, Zaremba, D., additional, Dohm, K., additional, Bürger, C., additional, Meinert, S. L., additional, Förster, K., additional, Repple, J., additional, Kaufmann, C., additional, Kugel, H., additional, Heindel, W., additional, Arolt, V., additional, Dannlowski, U., additional, and Baune, B. T., additional

Published
2016
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27. Innovating and trading TV formats through brand management practices

Author

Siegert, G., Förster, K., Chan-Olmsted, S., Ots, M., Singh, Sukhpreet, Oliver, John, Siegert, G., Förster, K., Chan-Olmsted, S., Ots, M., Singh, Sukhpreet, and Oliver, John

Abstract

Television formats form a major cultural export and yet, there is no protection under copyright law. Format copycats or imitators freely develop game, reality and talent shows based on successful format ideas. Despite this, the format industry has developed an ingenious and complex suite of market based practices that are allowing a thriving format industry to appear. This chapter discusses how TV format makers use brand management practices, in the absence of any legal solutions, to innovate and trade in their products. These include a number of practices such as: developing and managing the format brand identity, developing localized brand extensions and leveraging the producers brand reputation.

Published
2015

28. 20 years of research on media brands and media branding

Author

Siegert, Gabriele, Förster, Kati, Chan-Olmsted, Sylvia, Ots, Mart, Siegert, G ( Gabriele ), Förster, K ( Kati ), Chan-Olmsted, S ( Sylvia ), Ots, M ( Mart ), Krebs, Isabelle; https://orcid.org/0000-0002-4361-7866, Siegert, Gabriele, Förster, Kati, Chan-Olmsted, Sylvia, Ots, Mart, Siegert, G ( Gabriele ), Förster, K ( Kati ), Chan-Olmsted, S ( Sylvia ), Ots, M ( Mart ), and Krebs, Isabelle; https://orcid.org/0000-0002-4361-7866

Abstract

The purpose of this paper is to investigate the research output on media brands and media branding over the past 20 years. A meta-analysis was conducted to detect publications and investigate the structure, the theoretical approaches, as well as utilized methods and analyses of research output published in German and English. Thus, a broad overview on the developing area of media branding within the field of media economics and management is provided. Overall the meta-analysis revealed a prevalence of empirical studies and on TV as the dominant medium investigated. Furthermore, management and strategy is shown to be the primary theoretical research focus.

Published
2015

29. Media brands and the advertising market: exploring the potential of branding in media organizations’ B2B relationships

Author

Siegert, Gabriele, Förster, Kati, Chan-Olmsted, Sylvia, Ots, Mart, Siegert, G ( Gabriele ), Förster, K ( Kati ), Chan-Olmsted, S ( Sylvia ), Ots, M ( Mart ), Sommer, Christoph, Siegert, Gabriele, Förster, Kati, Chan-Olmsted, Sylvia, Ots, Mart, Siegert, G ( Gabriele ), Förster, K ( Kati ), Chan-Olmsted, S ( Sylvia ), Ots, M ( Mart ), and Sommer, Christoph

Published
2015

30. Media brand loyalty through online audience integration?

Author

Siegert, Gabriele, Förster, Kati, Chan-Olmsted, Sylvia, Ots, Mart, Siegert, G ( Gabriele ), Förster, K ( Kati ), Chan-Olmsted, S ( Sylvia ), Ots, M ( Mart ), Lischka, Juliane A, Siegert, Gabriele, Förster, Kati, Chan-Olmsted, Sylvia, Ots, Mart, Siegert, G ( Gabriele ), Förster, K ( Kati ), Chan-Olmsted, S ( Sylvia ), Ots, M ( Mart ), and Lischka, Juliane A

Abstract

This chapter discusses the question whether audience members become loyal toward a media brand when sharing, liking or commenting on online media content – or are loyal readers more inclined to write comments on online articles or to like and share them? The aim is to answer this chicken-egg causality dilemma on the audience integration-loyalty relation on a theoretical basis. Therefore, the concept of attitude-behavior consistency, the theory of reasoned action, involvement theory, uses and gratifications theory, and current research are reviewed. In conclusion, audience integration can be defined as behavioral dimension of loyalty and affects gratifications obtained that determine satisfaction, which in turn determines loyalty and future gratifications sought.

Published
2015

31. Market driven media brands: Supporting or faking high journalistic quality?

Author

Siegert, Gabriele, Förster, Kati, Chan-Olmsted, Sylvia, Ots, Mart, Siegert, G ( Gabriele ), Förster, K ( Kati ), Chan-Olmsted, S ( Sylvia ), Ots, M ( Mart ), Siegert, Gabriele, Förster, Kati, Chan-Olmsted, Sylvia, Ots, Mart, Siegert, G ( Gabriele ), Förster, K ( Kati ), Chan-Olmsted, S ( Sylvia ), and Ots, M ( Mart )

Published
2015

32. Branding media content from storytelling to distribution

Author

Siegert, Gabriele, Förster, Kati, Chan-Olmsted, Sylvia, Ots, Mart, Siegert, G ( Gabriele ), Förster, K ( Kati ), Chan-Olmsted, S ( Sylvia ), Ots, M ( Mart ), von Rimscha, M Bjørn, Siegert, Gabriele, Förster, Kati, Chan-Olmsted, Sylvia, Ots, Mart, Siegert, G ( Gabriele ), Förster, K ( Kati ), Chan-Olmsted, S ( Sylvia ), Ots, M ( Mart ), and von Rimscha, M Bjørn

Published
2015

35. COPD beim jungen Nichtraucher – oder doch was Anderes? Primäre Trachealtumore bei jungen Patienten

Author

Straßburg, J, Pereszlenyi, A, Sklenar, S, Morgen, R, Förster, K, and Eggeling, S

Subjects
ddc: 610, 610 Medical sciences, Medicine
Abstract

Einleitung: Wir berichten über 2 junge Nichtraucher (♂31 J. und ♀38 J.) die bei V.a. COPD seit Monaten mit einer inhalativen Medikation behandeltwurden und uns nun bei progredienterSymptomatikvorgestellt wurden. Spirometrisch ergab sich bei beiden einemittelschwere obstruktive Ventilationsstörung[for full text, please go to the a.m. URL], 21. Jahrestagung der Deutschen Gesellschaft für Thoraxchirurgie

Published
2012
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37. Secretion of Interleukin-10 by CD4+CD45RO+ memory T-cells correlates with declining CD4+ T-counts in HIV+ individuals

Author

Förster, K, Lehmann, C, Meuer, EK, Jung, N, and Hartmann, P

Subjects
ddc: 610, 610 Medical sciences, Medicine
Abstract

Objectives: Interferonα (IFNα) and Interleukin-10 (IL-10) are upregulated during HIV infection and increased serum levels of these cytokines are associated with disease progression. The aim of this study was to identify CD4+T-cell subsets as a source of IL-10, and to study the relation[for full text, please go to the a.m. URL], 10. Kongress für Infektionskrankheiten und Tropenmedizin (KIT 2010)

Published
2010
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39. The advanced German hyperspectral mission EnMAP

Author

Stuffler, T., Kaufmann, H., Hofer, S., Förster, K., Graue, R., Kampf, D., Mehl, H., Schreier, G., Mueller, A., Arnold, G., Bach, H., Benz, U., Jung-Rothenhäusler, F., and Haydn, R.

Subjects
550 - Earth sciences
Published
2005

43. ESCIMO.spread (v2): parameterization of a spreadsheet-based energy balance snow model for inside-canopy conditions.

Author

Marke, T., Mair, E., Förster, K., Hanzer, F., Garvelmann, J., Pohl, S., Warscher, M., and Strasser, U.

Subjects
SNOW, FOREST canopy ecology, METEOROLOGICAL observations
Abstract

This article describes the extension of the spreadsheet-based point energy balance snow model ESCIMO.spread by (i) an advanced approach for precipitation phase detection, (ii) a concept for cold and liquid water storage consideration and (iii) a canopy sub-model that allows to quantify the effect of a forest canopy on the meteorological conditions inside the forest as well as the simulation of snow accumulation and ablation inside a forest stand. To provide the data for model application and evaluation, innovative low-cost Snow Monitoring Systems (SnoMoS) have been utilized that allow the collection of important meteorological and snow information in and outside the canopy. The model performance with respect to both, the modification of meteorological conditions as well as the subsequent calculation of the snow cover evolution are evaluated using in- and outside-canopy observations of meteorological variables and snow cover evolution as provided by a pair of SnoMoS for a site in the Black Forest mountain range (south-west Germany). The validation results indicate a good overall model performance in and outside the forest canopy. The newly developed version of the model refered to as ESCIMO.spread (v2) is provided free of charge together with one year of sample data including the meteorological data and snow observations used in this study. [ABSTRACT FROM AUTHOR]

Published
2015
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