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2. Citrus reticulata Olive Oil: Production and Nutraceutical Effects on the Cardiovascular System in an In Vivo Rat Model of Metabolic Disorder.

Author

Spezzini, Jacopo, Ciccone, Valerio, Macaluso, Monica, Pieracci, Ylenia, Flamini, Guido, Donnini, Sandra, Calderone, Vincenzo, Testai, Lara, and Zinnai, Angela

Abstract

Recently, there has been significant exploration into the utilization of food by-products as natural reservoirs of bioactive substances, particularly in the creation of functional foods naturally enriched with antioxidants. Citrus peels represent a viable option for formulating enhanced olive oils that contribute to a healthier diet, due to their bioactive compound content. This study aimed to (i) ascertain the compositional characteristics of Citrus reticulata olive oil (CrOO) and (ii) assess its nutraceutical properties in rats with metabolic disorder induced by 3 weeks of feeding with a high-fat diet (HFD). The results showed a peculiar phytochemical composition, thanks to the contribution of citrus peels, which are excellent bio-products. In addition, it demonstrated HFD-induced weight gain (18 ± 2% for HFD vs. 13 ± 0.9% for CrOO) and showed protective effects on fasting blood glucose levels (90.2 ± 3.8 mg/dL for HFD vs. 72.3 ± 2.6 for CrOO). Furthermore, a reduction in cardiovascular risk (total cholesterol/HDL cholesterol = 5.0 ± 0.3 for HFD vs. 3.8 ± 0.3 for CrOO) and an improvement in myocardial tissue function were observed, as well as a significant reduction in inflammatory mediators such as iNOS, COX-2, and mPGES-1 in aortic vessel tissues, thus preserving endothelial function at the vascular level. [ABSTRACT FROM AUTHOR]

Published
2024
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3. Retrospective Study on the Features and Outcomes of a Tuscany COVID-19 Hospitalized Patients Cohort: Preliminary Results.

Author

Silvestri, Caterina, Stasi, Cristina, Profili, Francesco, Bartolacci, Simone, Sessa, Emiliano, Tacconi, Danilo, Villari, Liliana, Carrozzi, Laura, Dotta, Francesco, Bargagli, Elena, Donnini, Sandra, Masotti, Luca, Rasero, Laura, Lavorini, Federico, Pistelli, Francesco, Chimera, Davide, Sorano, Alessandra, Pacifici, Martina, Milli, Caterina, and Voller, Fabio

Subjects
GAMMA-glutamyltransferase, LIVER enzymes, INTENSIVE care units, ALANINE aminotransferase, COVID-19 pandemic
Abstract

Background: A few months after the COVID-19 pandemic onset, knowledge of SARS-CoV-2 infection and outcomes and treatments blew up. This paper aimed to evaluate the features of a Tuscany COVID-19 hospitalized cohort and to identify risk factors for COVID-19 severity. Methods: This retrospective observational COVID-19 cohort study (1 March 2020–1 March 2021) was conducted on patients ≥ 18 years old, admitted to Tuscany Hospital, and subjected to follow-up within 12 months after discharge. Patients were enrolled at Pisana, Senese and Careggi University Hospitals, and South East, North West, and Center Local Hospitals. Results: 2888 patients (M = 58.5%, mean age = 66.2 years) were enrolled, of whom 14.3% (N = 413) were admitted to an intensive care unit. Smokers were 25%, and overweight and obese 65%. The most used drugs were corticosteroids, antacids, antibiotics, and antithrombotics, all antiviral drugs, with slight differences between 2020 and 2021. A strong association was found between outcomes of evolution towards critical COVID-19 (non-invasive mechanical ventilation (NIV) and/or admission to intensive care) and smoking (RR = 4.91), ex-smoking (RR = 3.48), overweight (RR = 1.30), obese subjects (RR = 1.62), comorbidities (aRR = 1.38). The alteration of liver enzymes (aspartate aminotransferase, alanine aminotransferase, or gamma-glutamyl transpeptidase) was associated with NIV (aOR = 2.28). Conclusions: Our cohort, characterized by patients with a mean age of 66.2 years, showed 65% of patients were overweight and obese. Smoking/ex-smoking, overweight/obesity, and other comorbidities were associated with COVID-19 adverse outcomes. The findings also demonstrated that alterations in liver enzymes were associated with worse outcomes. [ABSTRACT FROM AUTHOR]

Published
2024
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4. Validity of Italian administrative healthcare data in describing the real-world utilization of infusive antineoplastic drugs: the study case of rituximab use in patients treated at the University Hospital of Siena for onco-haematological indications

Author

Bartolini, Claudia, primary, Roberto, Giuseppe, additional, Girardi, Anna, additional, Moscatelli, Valentino, additional, Spini, Andrea, additional, Barchielli, Alessandro, additional, Bocchia, Monica, additional, Fabbri, Alberto, additional, Donnini, Sandra, additional, Ziche, Marina, additional, Monti, Maria Cristina, additional, and Gini, Rosa, additional

Published
2023
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9. Uncovering Knowledge Gaps in the Safety Profile of Antiangiogenic Drugs in Cancer Patients: Insights from Spontaneous Reporting Systems Studies.

Author

Ciccone, Valerio, Ziche, Marina, Spini, Andrea, and Donnini, Sandra

Subjects
NEOVASCULARIZATION inhibitors, ANTINEOPLASTIC agents, CANCER patients, DRUG side effects, MEDICATION safety, CARDIOVASCULAR agents, RADIOACTIVE waste disposal
Abstract

Global repositories of postmarketing safety reports improve understanding of real-life drug toxicities, often not observed in clinical trials. The aim of this scoping review was to map the evidence from spontaneous reporting systems studies (SRSs) of antiangiogenic drugs (AADs) in cancer patients and highlight if the found disproportionality signals of adverse events (AEs) were validated and thus mentioned in the respective Summary of product Characteristics (SmPC). This scoping review was conducted according to PRISMA guidelines for scoping reviews. A knowledge gap on the safety of AADs was found: firstly, several cardiovascular AEs were not mentioned in the SmPCs and no pharmacovigilance studies were conducted despite the well-known safety concerns about these drugs on the cardiovascular system. Second, a disproportionality signal (not validated through causality assessment) of pericardial disease was found in the literature for axitinib with no mention in SmPC of the drug. Despite the exclusion of pharmacoepidemiological studies, we believe that this scoping review, which focuses on an entire class of drugs, could be considered as a novel approach to highlight possible safety concerns of drugs and as a guide for the conduction of a target postmarketing surveillance on AADs. [ABSTRACT FROM AUTHOR]

Published
2023
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10. The Nutraceutical Value of Olive Oil and Its Bioactive Constituents on the Cardiovascular System. Focusing on Main Strategies to Slow Down Its Quality Decay during Production and Storage

Author

Flori Lorenzo, Donnini Sandra, Calderone Vincenzo, Zinnai Angela, Taglieri Isabella, Venturi Francesca, and Testai Lara

Subjects
olive oil, polyphenols, vitamin E, oleic acid, shelf life, nutraceutical value, storage temperature, packaging, light exposure, Nutrition. Foods and food supply, TX341-641
Abstract

Cardiovascular diseases represent the principal cause of morbidity and mortality worldwide. It is well-known that oxidative stress and inflammatory processes are strongly implicated in their pathogenesis; therefore, anti-oxidant and anti-inflammatory agents can represent effective tools. In recent years a large number of scientific reports have pointed out the nutraceutical and nutritional value of extra virgin olive oils (EVOO), strongholds of the Mediterranean diet, endowed with a high nutritional quality and defined as functional foods. In regard to EVOO, it is a food composed of a major saponifiable fraction, represented by oleic acid, and a minor unsaponifiable fraction, including a high number of vitamins, polyphenols, and squalene. Several reports suggest that the beneficial effects of EVOO are linked to the minor components, but recently, further studies have shed light on the health effects of the fatty fraction and the other constituents of the unsaponifiable fraction. In the first part of this review, an analysis of the clinical and preclinical evidence of the cardiovascular beneficial effects of each constituent is carried out. The second part of this review is dedicated to the main operating conditions during production and/or storage that can directly influence the shelf life of olive oil in terms of both nutraceutical properties and sensory quality.

Published
2019
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13. Chapter 1. Introducion, How tumor-endothelial cell communication within the tumor microenvironment affects angiogenesis

Author

Morbidelli, Lucia and Donnini, Sandra

Subjects
angiogenic switch, proliferation, angiogenic factors, tumor microenvironment, tumor angiogenesis, migration, angiogenic inhibitor, endothelial cells, endothelial cell heterogeneity, tumor angiogenesis, tumor microenvironment, angiogenic factors, angiogenic inhibitor, angiogenic switch, endothelial cells, proliferation, migration, endothelial cell heterogeneity
Published
2022

14. Chapter 2. Antiangiogenic drugs: Chemosensitizers for combination cancer therapy

Author

Donnini, Sandra, Filippelli, Arianna, Ciccone, Valerio, Spini, Andrea, Emma, Ristori, Ziche, Marina, and Morbidelli, Lucia

Subjects
immune checkpoint inhibitors, combination cancer therapy, tyrosine kinase inhibitors, tumor microenvironment, Angiogenesis, tumor vessels, antiangiogenic drugs, chemotherapy, Angiogenesis, VEGF, tumor vessels, vascular normalization, tumor microenvironment, antiangiogenic drugs, chemotherapy, tyrosine kinase inhibitors, immune checkpoint inhibitors, combination cancer therapy, VEGF, vascular normalization
Published
2022

15. First-Line Pharmacotherapies and Survival among Patients Diagnosed with Non-Resectable NSCLC: A Real-Life Setting Study with Gender Prospective

Author

Spini, Andrea, primary, Gini, Rosa, additional, Rosellini, Pietro, additional, Singier, Allison, additional, Bellan, Cristiana, additional, Pascucci, Alessandra, additional, Leoncini, Lorenzo, additional, Mathieu, Clément, additional, Martellucci, Ignazio, additional, Furiesi, Folco, additional, Giorgi, Silvano, additional, Donnini, Sandra, additional, Roberto, Giuseppe, additional, Ziche, Marina, additional, and Salvo, Francesco, additional

Published
2021
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19. By-Products from Winemaking and Olive Mill Value Chains for the Enrichment of Refined Olive Oil: Technological Challenges and Nutraceutical Features

Author

Macaluso, Monica, primary, Bianchi, Alessandro, additional, Sanmartin, Chiara, additional, Taglieri, Isabella, additional, Venturi, Francesca, additional, Testai, Lara, additional, Flori, Lorenzo, additional, Calderone, Vincenzo, additional, De Leo, Marinella, additional, Braca, Alessandra, additional, Ciccone, Valerio, additional, Donnini, Sandra, additional, Guidi, Luca, additional, and Zinnai, Angela, additional

Published
2020
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22. Development of Fortified Citrus Olive Oils: From Their Production to Their Nutraceutical Properties on the Cardiovascular System

Author

Flori, Lorenzo, primary, Macaluso, Monica, additional, Taglieri, Isabella, additional, Sanmartin, Chiara, additional, Sgherri, Cristina, additional, De Leo, Marinella, additional, Ciccone, Valerio, additional, Donnini, Sandra, additional, Venturi, Francesca, additional, Pistelli, Luisa, additional, Martelli, Alma, additional, Calderone, Vincenzo, additional, Testai, Lara, additional, and Zinnai, Angela, additional

Published
2020
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23. Real word evidence on rituximab utilization: Combining administrative and hospital-pharmacy data

Author

Roberto, Giuseppe, primary, Spini, Andrea, additional, Bartolini, Claudia, additional, Moscatelli, Valentino, additional, Barchielli, Alessandro, additional, Paoletti, Davide, additional, Giorgi, Silvano, additional, Fabbri, Alberto, additional, Bocchia, Monica, additional, Donnini, Sandra, additional, Gini, Rosa, additional, and Ziche, Marina, additional

Published
2020
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28. Additional file 2: of Stemness marker ALDH1A1 promotes tumor angiogenesis via retinoic acid/HIF-1Îą/VEGF signalling in MCF-7 breast cancer cells

Author

Ciccone, Valerio, Terzuoli, Erika, Donnini, Sandra, Giachetti, Antonio, Morbidelli, Lucia, and Ziche, Marina

Subjects
skin and connective tissue diseases
Abstract

Figure S1. Loss-of function and gain-of function validation to study ALDH1A1 in MCF-7 cells. a. RT-PCR in breast tumor cells (Src and ALDH1A1KD, clones shA and shB) cultured in 10 % FBS for 48 h. ***p < 0.001 vs Scr cells. b. Western blot analysis of breast tumor cells (Src and ALDH1A1KD, clones shA and shB) cultured in 10 % FBS for 48 h. c. RT-PCR analysis of MCF-7 (Src, ALDH1A1KD and ALDH1A1+) cultured in 10 % FBS for 48 h. ***p < 0.001 vs MCF-7 Scr. ###p < 0.001 vs MCF-7 ALDH1A1KD (n = 3). d. Western blot analysis of MCF-7 (Src, ALDH1A1KD and ALDH1A1+) cultured in 10 % FBS for 48 h. β-actin was used as loading control. Gel shown is representative of three experiments with similar results. e. Enzymatic activity in MCF-7 ALDH1A1KD and ALDH1A1+ evaluated by NADH production. Data are reports as in Figure 1. ***p < 0.001 vs MCF-7 Scr. ###p < 0.001 vs MCF-7 ALDH1A1KD. (PDF 372 kb)

Published
2018
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29. Aquaporin Membrane Channels in Oxidative Stress, Cell Signaling, and Aging: Recent Advances and Research Trends

Author

Tamma, Grazia, Valenti, Giovanna, Grossini, Elena, Donnini, Sandra, Marino, Angela, Marinelli, Raul A., and Calamita, Giuseppe

Subjects
Article Subject
Abstract

Reactive oxygen species (ROS) are produced as a result of aerobic metabolism and as by-products through numerous physiological and biochemical processes. While ROS-dependent modifications are fundamental in transducing intracellular signals controlling pleiotropic functions, imbalanced ROS can cause oxidative damage, eventually leading to many chronic diseases. Moreover, increased ROS and reduced nitric oxide (NO) bioavailability are main key factors in dysfunctions underlying aging, frailty, hypertension, and atherosclerosis. Extensive investigation aims to elucidate the beneficial effects of ROS and NO, providing novel insights into the current medical treatment of oxidative stress-related diseases of high epidemiological impact. This review focuses on emerging topics encompassing the functional involvement of aquaporin channel proteins (AQPs) and membrane transport systems, also allowing permeation of NO and hydrogen peroxide, a major ROS, in oxidative stress physiology and pathophysiology. The most recent advances regarding the modulation exerted by food phytocompounds with antioxidant action on AQPs are also reviewed.

Published
2018
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30. Additional file 3: of Stemness marker ALDH1A1 promotes tumor angiogenesis via retinoic acid/HIF-1Îą/VEGF signalling in MCF-7 breast cancer cells

Author

Ciccone, Valerio, Terzuoli, Erika, Donnini, Sandra, Giachetti, Antonio, Morbidelli, Lucia, and Ziche, Marina

Subjects
skin and connective tissue diseases
Abstract

Figure S2. ALDH1A1 activity promotes the release of angiogenic factors in MCF-7. a. Cytokine ELISA plate array in supernatants of MCF-7 treated with CM037 (1 ÎźM) for 48 h. b. Western blot analysis for ALDH1A1 and VEGF on MCF-7 transiently silenced for ALDH1A1 (two sequences of SiRNA, A and B). (PDF 363 kb)

Published
2018
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31. Oxidative Stress and Membrane Transport Systems

Author

Marino, Angela, Dossena, Silvia, Tamma, Grazia, and Donnini, Sandra

Subjects
Aging, Article Subject, lcsh:Cytology, Chemistry, Membrane Transport Proteins, Biological Transport, Cell Biology, General Medicine, Membrane transport, medicine.disease_cause, Reactive Nitrogen Species, Biochemistry, Oxidative Stress, Editorial, Alzheimer Disease, Cardiovascular Diseases, medicine, Biophysics, Humans, lcsh:QH573-671, Reactive Oxygen Species, Oxidative stress
Published
2018
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39. Divergent effects of quercetin conjugates on angiogenesis

Author

Donnini, Sandra, Finetti, Federica, Lusini, Lorenzo, Morbidelli, Lucia, Cheynier, Veronique, Barron, Denis, Williamson, Gary, Waltenberger, Johannes, Ziche, Marina, Donnini, Sandra, Finetti, Federica, Lusini, Lorenzo, Morbidelli, Lucia, Cheynier, Veronique, Barron, Denis, Williamson, Gary, Waltenberger, Johannes, and Ziche, Marina

Abstract

The present study reports the activities of quercetin and its main circulating conjugates in man (quercetin-3′-sulphate (Q3′S) and quercetin-3-glucuronide (Q3G)) on in vivo angiogenesis induced by vascular endothelial growth factor (VEGF) and examines the effects of these molecules on cultured endothelial cells. We found opposing effects of quercetin and its metabolites on angiogenesis. While quercetin and Q3G inhibited VEGF-induced endothelial cell functions and angiogenesis, Q3′S per se promoted endothelial cell proliferation and angiogenesis. The inhibitory effect elicited by Q3G was linked to inhibition of extracellular signal-regulated kinases 1/2 (ERK1/2) phosphorylation elicited by VEGF. The activation of endothelial cells by Q3′S was associated to stimulation of VEGF receptor-2 and to downstream signalling activation (phosphatidylinositol-3 kinase/Akt and nitric oxide synthase pathways), ultimately responsible for ERK1/2 phosphorylation. These data indicate that the effects of circulating quercetin conjugates on angiogenesis are different depending on the nature of the conjugate. Q3G andQ3′S are the two major conjugates in plasma, but their ratio is dependenton several factors, so thatinhibition or activation of angiogenesis could be subtly shifted as a result of metabolismin vivo

Published
2017

45. Late Breaking Science posters657Aldehyde Dehydrogenase2 regulates senescence in the vascular endothelium658Monoamine oxidase is over-activated in the left and right ventricles from human ischemic hearts: an intriguing therapeutic target659A novel assay for regulating transcription factors by flow660Remote ischaemic conditioning reduces infarct size in animal in vivo models of ischaemia-reperfusion injury: a systematic review and meta-analysis661The Role of Histone Methyl-transferase G9a in Heart Homeostasis and Cardiac Hypertrophy: a Potential Therapeutic Target for Heart Failure663The extracellular matrix SPARCs cardiac contraction during health and disease664A proteomic investigation into the mechanisms of VEGF-adhesion receptor crosstalk in endothelial cells665Assessing the role of PMCA1 in arrhythmia development relating to β-adrenergic signalling667The expression of beta myosin isoform MYH7B correlates with severity of left ventricular systolic dysfunction in patients with hypertrophic cardiomyopathy668Spatial heterogeneity of sympathetic response in the rabbit myocardium

Author

Donnini, Sandra, primary, Miceli, Caterina, primary, Krams, R.M., primary, Bromage, Daniel, primary, Papait, Roberto, primary, Johnson, Daniel, primary, James, Jenny, primary, Wilson, Claire, primary, Sartorio, Carmem Luiza, primary, Anderson, SE., primary, Terzuoli, Erika, additional, Finetti, Federica, additional, Ziche, Marina, additional, Rigacci, Stefania, additional, Bargelli, Valentina, additional, Giordano, Carla, additional, Raimondi, Laura, additional, Nediani, Chiara, additional, Miceli, Caterina, additional, Pedrigi, R.M., additional, Kis, Z., additional, Pickard, Jack, additional, Rossello, Xavier, additional, Burke, Niall, additional, Ziff, Oliver, additional, Yellon, Derek, additional, Davidson, Sean, additional, Pagiatakis, Christina, additional, Rusconi, Francesca, additional, Carullo, Pierluigi, additional, Serio, Simone, additional, Condorelli, Gianluigi, additional, Deckx, S, additional, Rienks, M., additional, Carai, P., additional, Van Deel, E., additional, Van Der Velden, J., additional, Sipido, K.R., additional, Heymans, S, additional, Papageorgiou, A., additional, Humphries, Jonathan, additional, Canfield, Ann, additional, Humphries, Martin, additional, Bertoli, Gloria, additional, Lazzeroni, Davide, additional, Rimoldi, Ornella, additional, Esposito, Alessandra, additional, Peretto, Giovanni, additional, Damascelli, Anna, additional, De Cobelli, Francesco, additional, Alfieri, Ottavio, additional, Camici, Paolo Guido, additional, Smith, GL., additional, and Myles, RC., additional

Published
2016
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