35 results on '"Domínguez-Cherit J"'
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2. Supplementary Material for: Clinical and Dermoscopic Features of the Scalp in 31 Patients with Dermatomyositis
- Author
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Jasso-Olivares, J.C., Tosti, A., Miteva, M., Domínguez-Cherit, J., and Díaz-González, J.M.
- Subjects
integumentary system - Abstract
Background: Scalp involvement is not directly evaluated in patients with dermatomyositis (DM). Therefore, the exact frequency of scalp dermatomyositis (SDM) and its clinical and trichoscopic characteristics have been poorly described. Objective: The aim of this study was to determine the frequency and clinical and dermoscopic features of SDM in patients diagnosed with DM. Methods: We performed a descriptive prospective, cross-sectional observational study that included all patients diagnosed with DM at a Mexican academic institute over the course of a year. Results: Twenty-four out of 31 patients with DM had scalp involvement at clinical examination, with a prevalence of 77.4%. SDM was clinically characterized by erythema in all cases, scales in 20 (83.3%) patients, nonscarring alopecia in 21 (87.5%) patients, pruritus in 17 (70.8%) patients, and poikiloderma of the scalp in 16 (51.6%) patients. Twenty-eight patients were evaluated by trichoscopy. The most consistent finding was the presence of enlarged capillaries, found in 20 (71.4%) cases, followed by peripilar casts (57.1%) and tufting and interfollicular scales in 14 (50%) cases. Twenty-two patients also had positive nail fold capillaroscopic features similar to those observed by trichoscopy. Limitations: The simple size was limited. Conclusions: Scalp involvement and alopecia are common in patients with DM, and trichoscopy shows features similar to those found at capillaroscopy. Trichoscopy is a very important tool for diagnosis of scalp involvement in patients with DM.
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- 2017
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3. 275 Oral vitamin D3 5000IU as an adjuvant In the treatment of atopic dermatitis: A randomized controlled trial
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Sanchez Armendariz, K., Garcia Gil, A., Contreras Ruiz, J., Karam Orante, M., and Dominguez Cherit, J.
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- 2017
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4. Lesiones de la mucosa bucal por administración de metotrexato en paciente con artritis reumatoide.
- Author
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Esquivel-Pedraza, L., Fernández-Cuevas, L., Sánchez-Jiménez, Y. M., Domínguez-Cherit, J., and Méndez-Flores, S.
- Abstract
Methotrexate is the cornerstone therapy for patients with rheumatoid arthritis, with well-established safety and efficacy profiles; however, this drug has the potential to cause serious adverse reactions, such as mucositis. The clinical characteristics of oral mucositis associated to methotrexate are unfrequently reported; thus, the purpose of this manuscript is to describe the oral findings observed in three patients with rheumatoid arthritis under methotrexate therapy. [ABSTRACT FROM AUTHOR]
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- 2017
5. Virus Reactivation With Eosinophilia and Systemic Symptoms: An Imitator of Immune Reconstitution Inflammatory Syndrome With an Excellent Clinical Response to Valganciclovir.
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Ramírez-Marín HA and Domínguez-Cherit JG
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- Humans, Valganciclovir therapeutic use, Virus Activation, Immune Reconstitution Inflammatory Syndrome diagnosis, Immune Reconstitution Inflammatory Syndrome drug therapy, Immune Reconstitution Inflammatory Syndrome etiology, Eosinophilia drug therapy, Drug Hypersensitivity Syndrome diagnosis, Drug Hypersensitivity Syndrome drug therapy, Drug Hypersensitivity Syndrome etiology
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- 2023
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6. Subungual Keratoacanthoma: Typical and Atypical Presentations of an Uncommon Nail Tumor.
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Figueroa-Ramos G, Gatica-Torres M, López-López K, and Domínguez-Cherit J
- Abstract
Introduction: Keratoacanthoma (KA) is a group of tumors of epidermal origin with controversial nature. Subungual keratoacanthoma (SUKA) is a rare and destructive variant with more aggressive behavior. SUKA appears as a rapidly growing, painful tumor beneath the nail plate that rapidly progresses to a mass that can measure up to 2 cm. The toe location is unusual. The diagnosis must be made based on the correlation of clinical, radiological, and histopathological findings., Case Presentation: We present two cases of patients diagnosed with SUKAs with different clinical presentations which ranged from very typical to uncommon one. Both cases were treated with simple excision without recurrences., Conclusion: SUKA is a rare subungual tumor. Nail bed location represents a more difficult diagnostic challenge. SUKA should be suspected in the context of persistent and progressive pain on a finger or toe, once more frequent painful tumors have been ruled out., Competing Interests: The authors have no conflicts of interest to declare., (© 2023 S. Karger AG, Basel.)
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- 2023
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7. [Clinical research and the pharmaceutical industry].
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Mimenza-Alvarado AJ, Arrieta O, Celis MA, Domínguez-Cherit J, Islas-Andrade S, Lifshitz A, Mansilla A, Martínez I, Moreno M, Reyes-Sánchez AA, Rocha-Arrieta LL, Ruiz-Argüelles GJ, Sotelo J, Verástegui E, Vilar-Compte D, and Toussaint S
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- 2023
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8. Cannabinoids and their therapeutic use.
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Islas-Andrade S, Rocha-Arrieta LL, Arrieta O, Celis MA, Domínguez-Cherit J, Lifshitz A, Mansilla-Olivares A, Martínez I, Mimenza AJ, Moreno M, Reyes-Sánchez AA, Ruiz-Argüelles GJ, Soda-Merhy A, Sotelo J, Toussaint S, Vilar-Compte D, and Verástegui E
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- Humans, Cannabinoids therapeutic use
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- 2023
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9. Some reflections about physicians' updating.
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Ruiz-Argüelles GJ, Rocha-Arrieta LL, Arrieta O, Celis MA, Domínguez-Cherit J, Islas-Andrade S, Lifshitz A, Mansilla-Olivares A, Martínez I, Mimenza AJ, Moreno M, Reyes-Sánchez AA, Soda-Merhy A, Sotelo J, Toussaint S, Vilar-Compte D, and Verástegui E
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- 2023
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10. Giant Koenen Tumors as the Presenting and Only Clinical Sign of Tuberous Sclerosis Complex in a 56-Year-Old Man and Its Surgical Management.
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Olvera-Rodríguez V, Barrera Garibay AC, and Domínguez-Cherit J
- Abstract
Introduction: Tuberous sclerosis complex (TSC) is a genetic multisystem disorder with prominent skin involvement. Multiple ungual fibromas, also known as Koenen tumors (KTs), are one of the major diagnostic criteria and occur approximately in 50% of patients with TSC. They are disfiguring, painful, and challenging to treat as they frequently recur. There are 2 previous cases in the literature of KTs as the only clinical sign of TSC., Case Presentation: A 56-year-old male patient with intellectual disability presented with a history of ungual growths that had gradually increased in size and number for 20 years. The diagnosis of KTs was established on clinical grounds, without the requirement of histological confirmation. No additional clinical evidence of TSC was found. Complete surgical excision of the tumors located in the proximal nail matrix, periungual folds, and nail bed of each toe was successfully performed., Discussion: The association between KTs and intellectual disability with TSC supported the clinical diagnosis. To date, there is no standard first-line treatment for KTs. Complete surgical excision up to the proximal base of the tumor offers satisfactory results in terms of functionally and esthetic appearance and could be considered the preferred therapeutic modality for patients with severe functional and cosmetic impairment. Prompt recognition of the many signs and symptoms associated with TSC is important to achieve early diagnosis, preventing further complications., Competing Interests: The authors have no conflicts of interest to disclose., (Copyright © 2022 by S. Karger AG, Basel.)
- Published
- 2022
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11. [Syphilitic chancre in the mouth: an unusual location. Case report].
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Figueroa-Ramos G, Rodríguez-Gutiérrez G, and Domínguez-Cherit J
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- Male, Humans, Adult, Penicillin G Benzathine therapeutic use, Mouth, Syphilis diagnosis, Syphilis drug therapy, Chancre diagnosis, Chancre drug therapy, Skin Diseases
- Abstract
Background: Syphilis is an infectious disease caused by the spirochete Treponema pallidum, transmitted mainly by direct contact with the lesion. Primary syphilis usually presents with a chancre at the site of infection, which is highly contagious and resolves without treatment. The aim of this article is to illustrate an unusual location of a syphilitic chancre, in order to consider this diagnosis within the approach to patients with oral ulcers., Clinical Case: a 30-year-old man who presented a dermatosis located in the left labial commissure, characterized by a painless ulcer of 1 cm in diameter of 20 days of evolution. The patient has a history of HIV/AIDS. A punch biopsy of the dermatosis was performed, with a histopathological report compatible with syphilitic chancre and a negative VDRL result. He was treated with penicillin G benzathine showing improvement., Conclusions: Primary syphilis is characterized by the development of the syphilitic chancre, which is the first manifestation of syphilis in up to 60% of cases. Extragenital presentation is rare, with only 12-14% of all cases, and of these between 40-70% occur in the mouth, being the lips the most frequent location. Oral manifestations can represent a diagnostic challenge due to its wide spectrum of clinical presentations., (© 2022 Revista Médica del Instituto Mexicano del Seguro Social.)
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- 2022
12. Role of individual physicians in pharmacovigilance.
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Lifshitz A, Arrieta O, Celis MA, Domínguez-Cherit J, Islas-Andrade S, Mansilla-Olivares A, Martínez I, Mimenza-Alvarado AJ, Reyes-Sánchez AA, Rocha-Arrieta LL, Ruiz-Argüelles GJ, Soda-Merhy A, Sotelo-Morales J, Toussaint S, Vilar-Compte D, and Verástegui E
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- Humans, Pharmacovigilance, Health Knowledge, Attitudes, Practice, Physicians, Drug-Related Side Effects and Adverse Reactions
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- 2022
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13. Onycholemmal Horn: An Exceedingly Rare Subungual Tumor.
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Olvera-Rodríguez V, Toussaint-Caire S, and Domínguez-Cherit J
- Abstract
The onycholemmal horn is an exceedingly rare subungual tumor characterized by trichilemmal-like keratinization pattern. The only previous instance of onycholemmal horn dates back to 1983 when Haneke reported a keratotic subungual tumor clinically and histologically comparable to a trichilemmal horn. No other case of this condition has been reported so far. We present the case of a 72-year-old female patient, with a history of a slowly growing tumor originating from the nail bed epithelium of the left thumb. The lesion was surgically removed, and pathological examination was consistent with the diagnosis of an onycholemmal horn. Additionally, this study aims to elucidate the correlation between the onycholemmal and trichilemmal keratinization., Competing Interests: The authors have no conflicts of interest to disclose., (Copyright © 2021 by S. Karger AG, Basel.)
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- 2021
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14. Incidence of complications in dermatological surgery of melanoma and non-melanoma skin cancer in patients with multiple comorbidity and/or antiplatelet-anticoagulants. Five year experience in our Hospital.
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Arguello-Guerra L, Vargas-Chandomid E, Díaz-González JM, Méndez-Flores S, Ruelas-Villavicencio A, and Domínguez-Cherit J
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- Adult, Aged, Aged, 80 and over, Female, Hospitals, Humans, Incidence, Male, Melanoma complications, Middle Aged, Retrospective Studies, Skin Neoplasms complications, Time Factors, Young Adult, Anticoagulants therapeutic use, Melanoma surgery, Platelet Aggregation Inhibitors therapeutic use, Postoperative Complications epidemiology, Skin Neoplasms surgery
- Abstract
Introduction: Surgery is performed more frequently now at days, due to the increasing incidence of melanoma and no-melanoma skin cancer. There are different opinions among dermatologic surgeons between to continue or discontinue antithrombotic therapy prior to the procedure, which increases the risk of thromboembolic events. Prophylaxis with oral antibiotics in the postsurgical period is controversial., Objective: To report the safety of surgery without suspending antithrombotic therapy and without oral antibiotic prophylaxis in dermatology surgery of patients with multiple comorbidities and polypharmacy., Method: We designed a retrospective study. We included a total of 655 patients; 96.6% had at least one comorbidity; 27.7% used aspirin and 4.3% some type of antithrombotic therapy. The most common type of skin tumor was basal cell carcinoma with 69.8., Results: The complication rate was 4.2%; the most was wound dehiscence (1.1%), followed by partial necrosis (0.9%), infection (0.9%), reaction to foreign body (0.6%), complete necrosis (0.3%), bleeding (0.2%) and fistulae (0.2%)., Conclusions: Based on the literature and our experience, dermatologic surgery is safe without suspending antithrombotic therapy or antibiotic prophylaxis in patients with multiple comorbidity., (Copyright: © 2019 Permanyer.)
- Published
- 2019
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15. Subungual Metastasis of an Adenocarcinoma of the Prostate in a Finger.
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García-Galaviz R, Domínguez-Cherit J, Caro-Sánchez C, and Salazar-Rojas E
- Abstract
Cutaneous metastasis is a rare event occurring most frequently in patients previously diagnosed with cancer. However, subungual metastases are even less frequent. The most common neoplasms associated with the latter are lung, kidney, and breast neoplasms. Lung cancer is the main cause of subungual metastases in the fingers, and genitourinary tract tumors are the main cause of subungual metastases in the toes. This is the first case report of an adenocarcinoma of the prostate with subungual metastasis.
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- 2018
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16. Acral and Multicentric Pigmented Bowen's Disease in HIV-Positive Patients: Report on Two Unusual Cases.
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Fernández-Sánchez M, Charli-Joseph Y, Domínguez-Cherit J, Guzman-Herrera S, and Reyes-Terán G
- Abstract
In situ squamous cell carcinoma of the skin (SCCis or Bowen's disease) is a common intraepidermal cutaneous malignancy with a low invasive potential. Acral Bowen's disease is usually solitary, but multiple acral SCCis have been reported. Pigmented Bowen's disease is typically unilesional and characterized by a hyperpigmented plaque with a velvety of keratotic surface, which can eventually simulate melanoma clinically. We describe two HIV-positive patients who presented with multiple pigmented SCCis involving the distal extremities. In patients with immunosuppression, the presence of multiple and hyperpigmented verrucae that clinically do not respond to adequate treatment should raise the differential diagnosis of SCC in situ ., Competing Interests: There are no conflicts of interest.
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- 2018
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17. Incidence of complications in dermatological surgery of melanoma and non-melanoma skin cancer in patients with multiple comorbidity and/or antiplatelet-anticoagulants. Five year experience in our Hospital.
- Author
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Arguello-Guerra L, Vargas-Chandomid E, Díaz-González JM, Méndez-Flores S, Ruelas-Villavicencio A, and Domínguez-Cherit J
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- Adult, Aged, Aged, 80 and over, Antibiotic Prophylaxis, Anticoagulants therapeutic use, Comorbidity, Female, Humans, Incidence, Male, Mexico epidemiology, Middle Aged, Platelet Aggregation Inhibitors therapeutic use, Postoperative Hemorrhage chemically induced, Postoperative Hemorrhage epidemiology, Retrospective Studies, Surgical Wound Dehiscence epidemiology, Thromboembolism epidemiology, Thromboembolism prevention & control, Young Adult, Melanoma, Cutaneous Malignant, Anticoagulants adverse effects, Carcinoma, Basal Cell surgery, Carcinoma, Squamous Cell surgery, Melanoma surgery, Platelet Aggregation Inhibitors adverse effects, Postoperative Complications epidemiology, Skin Neoplasms surgery
- Abstract
Introduction: Surgery is performed more frequently now at days, due to the increasing incidence of melanoma and no-melanoma skin cancer. There are different opinions among dermatologic surgeons between to continue or discontinue antithrombotic therapy prior to the procedure, which increases the risk of thromboembolic events. Prophylaxis with oral antibiotics in the postsurgical period is controversial., Objective: To report the safety of surgery without suspending antithrombotic therapy and without oral antibiotic prophylaxis in dermatology surgery of patients with multiple comorbidities and polypharmacy., Method: We designed a retrospective study. We included a total of 655 patients; 96.6% had at least one comorbidity; 27.7% used aspirin and 4.3% some type of antithrombotic therapy. The most common type of skin tumor was basal cell carcinoma with 69.8% ., Results: The complication rate was 4.2%; the most was wound dehiscence (1.1%), followed by partial necrosis (0.9%), infection (0.9%), reaction to foreign body (0.6%), complete necrosis (0.3%), bleeding (0.2%) and fistulae (0.2%)., Conclusions: Based on the literature and our experience, dermatologic surgery is safe without suspending antithrombotic therapy or antibiotic prophylaxis in patients with multiple comorbidity., (Copyright: © 2018 Permanyer.)
- Published
- 2018
- Full Text
- View/download PDF
18. [Characteristics and risk factors for recurrence of cutaneous squamous cell carcinoma with conventional surgery and surgery with delayed intraoperative margin assessment].
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Domínguez-Cherit J, Rodríguez-Gutiérrez G, Narváez Rosales V, Toussaint Caire S, and Fonte Avalos V
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- Adult, Aged, Aged, 80 and over, Carcinoma, Squamous Cell pathology, Facial Neoplasms pathology, Facial Neoplasms surgery, Female, Humans, Male, Middle Aged, Neoplasm Invasiveness, Organ Specificity, Risk Factors, Skin Neoplasms pathology, Time Factors, Young Adult, Carcinoma, Squamous Cell surgery, Margins of Excision, Neoplasm Recurrence, Local epidemiology, Skin Neoplasms surgery, Wound Closure Techniques
- Abstract
Background: Non-melanoma skin cancer includes basal cell carcinoma and squamous cell carcinoma (SCC). Basal cell carcinoma is the most common and least aggressive but in a low percentage of cases, despite appropriate wide surgical margins, it can be aggressive, producing local invasion, recurrences and distance metastasis. SCC has a more aggressive behaviour invading first the skin, the lymph nodes and less frequently produces distance metastasis OBJECTIVE: To identify the characteristics of recurrent SCC and frequency of new SCC after conventional surgical and primary closure or closure delayed until a histological reporting of tumour-free surgical margins, in order to achieve a better surgical option, in our Mexican population., Materials and Method: We reviewed clinical records from the last 10 years, and included those with a diagnosis of SCC., Results: One hundred and fourteen tumours in 103 patients were included. The mean new tumour diagnosis was 32.2 per year; there were 46.6% men and 53.4% women. Age range 19-91, with mean 71.94 years (SD=13.34). The evolution time was from 1-112 months (mean=12 months, SD=2.65). The most affected site was the cheek. In addition, an invasive tumour was reported in 54% in the histopathological study. At 10-year follow-up we found a second SCC in 14 patients and only 4 recurrences, between the 1st and 4th year and 3were treated with delayed closure until margins were tumour-free., Conclusion: In this study we demonstrated that delayed closure technique is easy and adaptable in our population in the treatment of SCC, achieving good results with very low recurrences at 10- year follow -up., (Copyright © 2016 Academia Mexicana de Cirugía A.C. Publicado por Masson Doyma México S.A. All rights reserved.)
- Published
- 2017
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19. Clinical and Dermoscopic Features of the Scalp in 31 Patients with Dermatomyositis.
- Author
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Jasso-Olivares JC, Tosti A, Miteva M, Domínguez-Cherit J, and Díaz-González JM
- Abstract
Background: Scalp involvement is not directly evaluated in patients with dermatomyositis (DM). Therefore, the exact frequency of scalp dermatomyositis (SDM) and its clinical and trichoscopic characteristics have been poorly described., Objective: The aim of this study was to determine the frequency and clinical and dermoscopic features of SDM in patients diagnosed with DM., Methods: We performed a descriptive prospective, cross-sectional observational study that included all patients diagnosed with DM at a Mexican academic institute over the course of a year., Results: Twenty-four out of 31 patients with DM had scalp involvement at clinical examination, with a prevalence of 77.4%. SDM was clinically characterized by erythema in all cases, scales in 20 (83.3%) patients, nonscarring alopecia in 21 (87.5%) patients, pruritus in 17 (70.8%) patients, and poikiloderma of the scalp in 16 (51.6%) patients. Twenty-eight patients were evaluated by trichoscopy. The most consistent finding was the presence of enlarged capillaries, found in 20 (71.4%) cases, followed by peripilar casts (57.1%) and tufting and interfollicular scales in 14 (50%) cases. Twenty-two patients also had positive nail fold capillaroscopic features similar to those observed by trichoscopy., Limitations: The simple size was limited., Conclusions: Scalp involvement and alopecia are common in patients with DM, and trichoscopy shows features similar to those found at capillaroscopy. Trichoscopy is a very important tool for diagnosis of scalp involvement in patients with DM.
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- 2017
- Full Text
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20. A case series and a review of the literature on foreign modelling agent reaction: an emerging problem.
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Martínez-Villarreal AA, Asz-Sigall D, Gutiérrez-Mendoza D, Serena TE, Lozano-Platonoff A, Sanchez-Cruz LY, Toussaint-Caire S, Domínguez-Cherit J, López-García LA, Cárdenas-Sánchez A, and Contreras-Ruiz J
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- Adult, Aged, Breast physiopathology, Buttocks physiopathology, Cosmetics administration & dosage, Female, Homosexuality, Male statistics & numerical data, Humans, Male, Middle Aged, Mineral Oil administration & dosage, Retrospective Studies, Skin physiopathology, Young Adult, Cosmetics adverse effects, Foreign Bodies immunology, Foreign-Body Reaction complications, Mineral Oil adverse effects, Skin Ulcer etiology, Skin Ulcer therapy
- Abstract
Foreign modelling agent reactions (FMAR) are the result of the injection of unapproved high-viscosity fluids with the purpose of cosmetic body modelling. Its consequences lead to ulceration, disfigurement and even death, and it has reached epidemic proportions in several regions of the world. We describe a series of patients treated for FMARs in a specialised wound care centre and a thorough review of the literature. A retrospective chart review was performed from January 1999 to September 2015 of patients who had been injected with non-medical foreign agents and who developed cutaneous ulceration needing treatment at the dermatology wound care centre. This study involved 23 patients whose ages ranged from 22 to 67 years with higher proportion of women and homosexual men. The most commonly injected sites were the buttocks (38·5%), legs (18%), thighs (15·4%) and breasts (11·8%). Mineral oil (39%) and other unknown substances (30·4%) were the most commonly injected. The latency period ranged from 1 week to 17 years. Complications included several skin changes such as sclerosis and ulceration as well as systemic complications. FMAR is a severe syndrome that may lead to deadly complications, and is still very common in Latin America., (© 2016 Medicalhelplines.com Inc and John Wiley & Sons Ltd.)
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- 2017
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21. Oral and Cutaneous Lymphomas other than Mycosis Fungoides and Sézary Syndrome in a Mexican Cohort: Recategorization and Evaluation of International Geographical Disparities.
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Hernández-Salazar A, García-Vera JA, Charli-Joseph Y, Ortiz-Pedroza G, Méndez-Flores S, Orozco-Topete R, Morales-Leyte AL, Domínguez-Cherit J, and Lome-Maldonado C
- Abstract
Background: Nonmycosis fungoides/Sézary syndrome (non-MF/SS) primary cutaneous lymphomas (PCL) are currently categorized under the 2005-World Health Organization/European Organization for Research and Treatment of Cancer (WHO-EORTC) classification for PCL. These differ in behavior from secondary cutaneous lymphomas (SCL) and to lymphomas limited to the oral cavity (primary oral lymphomas [POL]) both categorized under the 2016-WHO classification for lymphoid neoplasms., Aims: This study aims to report the first series of non-MF/SS PCL, SCL, and POL in a Mexican cohort, examine the applicability of current classification systems and compare our findings with those from foreign cohorts., Materials and Methods: Eighteen non-MF/SS PCL, four SCL, and two POL with available tissue for morphology and immunophenotypic assessment were reclassified according to the 2005-WHO/EORTC and 2016-WHO classifications., Results: Non-MF/SS PCLs were primarily of T-cell origin (61%) where CD30+ lymphoproliferative disorders predominated, followed by Epstein-Barr virus-induced lymphomas, and peripheral T-cell lymphomas, not otherwise specified. Primary cutaneous B-cell lymphomas (BCL) were primarily of follicle center cell origin followed by postgerminal lymphomas of the diffuse large BCL variety., Conclusions: Most non-MF/SS PCL, SCL, and POL can be adequately categorized according to the 2005-WHO/EORTC and 2016-WHO classification systems, even when dealing with clinically atypical cases. The relative frequencies in our cohort hold closer similarities to Asian registries than from those of Europe/USA, supporting the concept of individual and/or racial susceptibility, and the notion of geographical variances in the rate of lymphomas. In particular, such disparity may arise from viral-induced lymphomas which might show partial geographical restriction., Competing Interests: There are no conflicts of interest. What is new? The relative frequencies of cutaneous and oral lymphomas in the first Mexican cohort hold closer similarities to Asian registries than from those of Europe and USAInternational geographical disparities in the rate of cutaneous lymphomas may arise from viral-induced lymphomas which might show partial geographical restriction.
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- 2017
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22. Conservative surgical management of in situ subungual melanoma: long-term follow-up.
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Anda-Juárez MC, Martínez-Velasco MA, Fonte-Ávalos V, Toussaint-Caire S, and Domínguez-Cherit J
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- Adolescent, Adult, Aged, Biopsy, Child, Child, Preschool, Dermoscopy, Female, Follow-Up Studies, Humans, Male, Melanoma pathology, Middle Aged, Nail Diseases pathology, Neoplasm Recurrence, Local, Reproducibility of Results, Skin Neoplasms pathology, Time Factors, Treatment Outcome, Young Adult, Melanoma surgery, Nail Diseases surgery, Skin Neoplasms surgery
- Abstract
Subungual melanoma represents 20% of all melanomas in Hispanic population. Here, we report the outcome of 15 patients with in situ subungual melanoma treated with resection of the nail unit with a 5-mm margin without amputation, followed up for 55.93 ± 43.08 months. The most common complications included inclusion cysts and nail spicules. We found no evidence of local or distant recurrences at the last visit of our follow up. Functional outcome was good, with only one patient reporting persistent mild pain. These results support functional, non-amputative surgical management of in situ subungual melanomas., Competing Interests: None
- Published
- 2016
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23. [Leukemia cutis: clinical features of 27 mexican patients and a review of the literature].
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Peña-Romero AG, Domínguez-Cherit J, and Méndez-Flores S
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- Adult, Age Distribution, Aged, Aged, 80 and over, Female, Humans, Leukemia, Lymphoid epidemiology, Leukemia, Myeloid epidemiology, Leukemia, Myeloid, Acute mortality, Leukemia, Myeloid, Acute pathology, Leukemic Infiltration mortality, Male, Mexico epidemiology, Middle Aged, Retrospective Studies, Sex Distribution, Young Adult, Leukemia, Lymphoid pathology, Leukemia, Myeloid pathology, Leukemic Infiltration pathology, Skin pathology
- Abstract
Background: Leukemia Cutis (LC) consists in neoplastic leukocytic infiltration of the skin and is strongly associated with the presence of extramedullary disease and poor prognosis. However, there are few studies in the literature regarding this entity. We perform a retrospective study of 27 mexican patients in order to analyze the clinical features and prognosis of LC in Mexico, and a brief review of the literature., Methods: Cases diagnosed as LC by skin biopsy were selected from the database of the Department of Dermatology of National Institute of Medical Science and Nutrition Salvador Zubirán. Cases were searched between the dates of January 1993 and December 2013., Results: Twenty-seven cases which were histologically confirmed with cutaneous leukemic infiltrate were included. Of these patients 60% were male and the mean age at diagnosis was 42 yr (19 to 80 yr). The predominant tipe of LC was acute myeloid leukemia (AML) with 48% of the cases. Nodular neoformations were the main clinical manifestation with 63% of the cases. The mean interval between the diagnosis of LC and death was 10 months (CI 95%)., Conclusions: The presence of LC is a marker of poor prognosis and can precede the relapse of systemic leukemia. Cutaneous infiltration may be the first or the only sign of progression, so doctors should be familiar with the clinical manifestations of this disease.
- Published
- 2016
24. Mottled Lunulae in Nail Psoriasis: Report of Three Cases.
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Peña-Romero A, Toussaint-Caire S, and Domínguez-Cherit J
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- 2016
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25. Nadroparin-induced skin necrosis: clinical manifestation of HIT-2 even in the absence of thrombocytopaenia.
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Pérez DL, Peña-Romero AG, Díaz-González JM, and Domínguez-Cherit J
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- Adult, Humans, Male, Necrosis, Skin Diseases pathology, Nadroparin adverse effects, Skin Diseases chemically induced, Thrombocytopenia chemically induced
- Published
- 2016
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26. Spectroscopic and Imaging Characteristics of Pigmented Non-Melanoma Skin Cancer and Melanoma in Patients with Skin Phototypes III and IV.
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Arroyo-Camarena S, Domínguez-Cherit J, Lammoglia-Ordiales L, Fabila-Bustos DA, Escobar-Pio A, Stolik S, Valor-Reed A, and de la Rosa-Vázquez J
- Abstract
Introduction: Non-melanoma skin cancer is the most common malignancy worldwide. Differentiating between malignant and benign skin tumors, however, can be challenging. As a result, various auxiliary tools have been developed to aid in the diagnosis of cutaneous neoplasms. Here, skin tumors were investigated through analysis of their digital image histograms and spectroscopic response under ultraviolet (UV) and white light-emitting diodes (LEDs)., Methods: Fifty tumoral lesions were spectroscopically and histologically studied. For optical studies, UV at 375 nm and white LEDs were used to illuminate the lesions. Commercial cameras were used for imaging, and a miniature spectrometer with a bifurcated optical fiber was used for spectroscopic measurements., Results: In this study, the intensity histograms of the images taken under white and UV illumination and the spectroscopic response under white light showed clear differences between pigmented basal cell carcinoma (BCC), intradermal melanocytic nevus (IDN), and melanoma lesions for skin phototypes III and IV. However, there was little difference in their spectroscopic response to the UV LED., Conclusion: We found differences in the intensity and shape of diffuse reflectance spectra of pigmented BCC, IDN, and melanoma lesions in patients with skin phototypes III and IV. Also, images taken under UV and white light were helpful for differentiation of these pigmented lesions. Additional research is needed to ascertain the clinical utility of these tools for skin cancer diagnosis.
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- 2016
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27. Under-reported Finding in Acral Erythema Multiforme.
- Author
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Peña-Romero AG, Domínguez-Cherit J, and Guzmán-Abrego AC
- Abstract
Erythema multiforme is an acute muco-cutaneous hypersensitivity reaction with a variety of etiologies. It is characterized by a skin eruption, with or without oral or other mucous membrane lesions. General characteristics and treatmet have been described, but nail findings are rarely reported Here we present a 26-year-old patient with acral erythema multiforme and erythronychia adjacent to skin lesions on the back of the hands. To our knowledge this association had not been reported before.
- Published
- 2015
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28. Pachydermoperiostosis, a unique entity with distinctive clinical features.
- Author
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Tinoco-Fragoso F, Méndez-Flores S, and Domínguez-Cherit J
- Subjects
- Biomarkers metabolism, Biopsy, Diagnosis, Differential, Dinoprostone metabolism, Humans, Male, Osteoarthropathy, Primary Hypertrophic metabolism, Vascular Endothelial Growth Factor A metabolism, Osteoarthropathy, Primary Hypertrophic diagnosis, Skin pathology
- Abstract
Pachydermoperiostosis, which occurs more frequently in men, is a rare entity with distinctive clinical features and an insidious onset.. We report the case of a 30-year-old man with a one-year history of acropachy, arthralgias, hiperhidrosis, and progressive skin thickening of the face and scalp. The radiological findings were consistent with periostosis and the histopathological analysis from a facial skin biopsy showed a pandermal increase in the thickness and number of collagen bundles. The pathogenesis of PDP is currently unknown, although an increased secretion of prostaglandin E2 (PGE2), which stimulates the overexpression of vascular endothelial growth factor (VEGF), has been suggested as a major factor. No specific treatment exists; however, in most cases, the disease tends to stabilize over time.
- Published
- 2015
29. [Sclerosing acral skin perineurioma: clinicopathologic study of ten cases (eight classical and two with xanthomatous changes)].
- Author
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Toussaint-Caire S, Aguilar-Donis A, Torres-Guerrero E, Asz-Sigall D, Vega-Memije ME, Lacy-Niebla RM, Domínguez-Cherit J, Alfaro Ledesma P, and Ortiz-Hidalgo C
- Subjects
- Adult, Aged, Child, Claudin-1 metabolism, Diagnosis, Differential, Female, Glucose Transporter Type 1 metabolism, Humans, Male, Middle Aged, Mucin-1 metabolism, Nerve Sheath Neoplasms diagnosis, Sclerosis pathology, Skin Neoplasms diagnosis, Xanthomatosis diagnosis, Nerve Sheath Neoplasms pathology, Skin Neoplasms pathology, Xanthomatosis pathology
- Abstract
Introduction: Perineurioma is an infrequent and benign cutaneous neoplasm characterized by proliferation of perineurial cells. It is classified into two main types: intraneural and the extraneural or soft tissue perineurioma, in which the sclerosing variant is included. Sclerosing perineurioma is more frequently found on acral skin. Clinically, they are well-circumscribed,skin colored, nodular tumors., Objective: Describe and communicate clinicopathologic findings from a case series of sclerosing acral perineurioma., Material and Methods: This is a clinical, morphological and immunohistologic case study of eight patients with the diagnosis of sclerosing perineurioma., Results: It included five men and five women, with ages ranging between nine and 66 years. All of them had lesion on acral skin. At microscopy study, the lesions showed a proliferation of epithelioid and spindle-shaped perineurial cells, arranged in small aggregates and short fascicles between thickened collagen bundles. Immunohistochemistry studies revealed that the proliferating cells expressed EMA, Claudin-1 and Glut-1, and were negative for S-100 protein., Conclusions: It is important to report these infrequent skin tumors, so they can be taken into account in the differential diagnoses of acral lesions.
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- 2015
30. [Patients with solid organ transplantation and skin cancer: determination of risk factors with emphasis in photoexposure and immunosuppressive regimen. Experience in a third level hospital].
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Rodríguez-Acosta ED, Calva-Mercado JJ, Alberú-Gómez J, Vilatoba-Chapa M, and Domínguez-Cherit J
- Subjects
- Adult, Carcinoma, Basal Cell etiology, Carcinoma, Basal Cell pathology, Carcinoma, Squamous Cell etiology, Carcinoma, Squamous Cell pathology, Case-Control Studies, Female, Humans, Immunosuppressive Agents therapeutic use, Incidence, Logistic Models, Male, Middle Aged, Multivariate Analysis, Risk Factors, Skin Neoplasms etiology, Skin Neoplasms pathology, Sunlight adverse effects, Sunscreening Agents administration & dosage, Surveys and Questionnaires, Young Adult, Carcinoma, Basal Cell epidemiology, Carcinoma, Squamous Cell epidemiology, Organ Transplantation methods, Skin Neoplasms epidemiology
- Abstract
Background: Non-melanoma skin cancer (NMSC) is the most common malignancy in transplant patients. The incidence of basal cell carcinoma (BCC) is 10 times greater than in the general population, while squamous cell carcinoma (SCC) is 100 times greater. The relationship between the BCC and SCC reverses and increases according to the degree of immunosuppression and sun exposure. One way to predict the risk of NMSC should be based on factors such as: total sun burden factor (TSB)., Objective: To determine the influence of various risk factors in the development of NMSC and its relation to the type and duration of immunosuppressive treatment, type of transplant, and TSB., Methods: We worked with a fledgling historical cohort in which patients with kidney or liver transplant were identified and recorded if they developed some form of skin cancer. To study the factors associated with NMSC, we resorted to the strategy of a case-control study. Dermatological examination was performed and a questionnaire of risk factors made in both groups., Results: Of the 140 patients enrolled, 51 were women and 89 men, 120 were renal transplant recipients and 20 liver transplants. Of patients who developed NMSC, 100% were renal transplant recipients. The median age was 48.5 years. Most cancer patients worked outdoors. A total of 78 lesions were found in 40 NMSC patients, 59 (76%) of them were SCC, and 19 (24%) BCC; 45% of all skin cancer patients had more than one injury. The worst affected areas were those photoexposed: 60% head and neck, trunk and upper extremities 18% 50%. In 30% of patients (12/40) 22 new tumors were identified (SCC 18 and BCC 4). No lesions were identified for melanoma. In multivariate logistic regression analysis, statistically significant features were: type-based immunosuppressive regimen of cyclosporine A, azathioprine and prednisone (OR: 59.7; 95% CI: 10.2-348), TSB > 10 (OR: 19; 95% CI: 3-120) and duration of use of immunosuppressive therapy (OR: 1.06; 95% CI: 0.9-1.1). The mean time from transplantation to first dermatological assessment was six years (+5.4). Of the patients, 93% had not regularly used sunscreen before and after transplantation., Conclusions: The dermatological assessment is convenient and easy to perform. Primary prevention, close monitoring, diagnosis, and treatment of skin lesions are essential components of a comprehensive program for the evaluation of transplant recipients, the purpose of which is to reduce the incidence and morbidity associated with cancer.
- Published
- 2015
31. [Clinical and histopathological characteristics of malignant melanoma cases seen at "Dr. Manuel Gea González" General Hospital].
- Author
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Káram-Orantes M, Toussaint-Caire S, Domínguez-Cherit J, and Veja-Memije E
- Subjects
- Adolescent, Adult, Aged, Aged, 80 and over, Cross-Sectional Studies, Female, Hospitals, Humans, Male, Melanoma epidemiology, Middle Aged, Retrospective Studies, Skin Neoplasms epidemiology, Melanoma pathology, Skin Neoplasms pathology
- Abstract
Background: Melanoma is a type of tumor that arises from melanocytes generally located in the dermoepidermal junction. Although melanoma is found in less than 10% of cases, mortality is high representing 75% of deaths attributed to cutaneous cancer. There are four major subtypes: Superficial spreading melanoma, lentigo malignant melanoma, acral lentiginous melanoma and nodular melanoma. Superficial spreading melanoma is the most common type among Caucasians. In a Mexican case series, the nodular type is the most common type reported. The aim of this study was to determine the most common type seen at our medical facility., Methods: We analyzed patient's medical records from March 1981 to December 2006. Demographic data included sex, age, place of residence, occupation, tumor progression, location and clinical description. Histologically we evaluated tumor thickness using the Breslow scale; invasion was measured using the Clark scale. This is a descriptive, cross-sectional and retrospective study., Results: 165 patients were studied, 112 were females and 53 males. The most common location was the lower limb. Acral lentiginous melanoma was the most common subtype., Conclusions: Our findings differ from the other series where they report nodular and superficial spreading melanoma as the most common types. The most common subtypes in our study were acral lentiginous melanoma and lentigo malignant melanoma among females, with a ratio of female-male of 2.1:1.
- Published
- 2008
32. [Confluent and reticulated Gougerot-Carteaud papillomatosis: a case report of an excellent response to minocycline].
- Author
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Rodríguez-Carreón AA, Arenas-Guzmán R, Fonte-Avalos V, Gutiérrez-Mendoza D, Vega-Memije ME, and Domínguez-Cherit J
- Subjects
- Adolescent, Humans, Male, Papilloma pathology, Skin Neoplasms pathology, Anti-Bacterial Agents therapeutic use, Minocycline therapeutic use, Papilloma drug therapy, Skin Neoplasms drug therapy
- Abstract
Confluent and reticulated Gougerot-Carteaud papillomatosis is an uncommon dermatological condition that affects adolescents, especially young women with dark skin types. It presents itself as asymptomatic pigmented patches with a papillomatous texture that coalesce to form reticular plaques localized in the neck and intertriginous areas. The cause of this disease is unknown, although an abnormal keratinization has been implicated and sometimes has been associated with Malassezia sp. It has a chronic course with remissions and exacerbations. Several therapies have been used unsuccessfully to eradicate it but nowadays there is no specific treatment. We report a case treated efficiently with minocycline without recurrence at 6 months follow-up.
- Published
- 2008
33. [Frequency of benign tumors at the Hospital General "Dr. Manuel Gea Gonzalez". Record review between 2000-2006].
- Author
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Káram-Orantes M, Fonte-Avalos V, Zuloaga-Salcedo S, and Domínguez-Cherit J
- Subjects
- Adolescent, Adult, Aged, Aged, 80 and over, Child, Female, Hospitals, General, Humans, Male, Middle Aged, Neoplasms pathology, Retrospective Studies, Neoplasms epidemiology
- Abstract
Background: Benign skin neoplasms are defined as autonomous growing tissue unrelated to normal growing of the skin, that persist even after the originating stimulus dissapears. Almost all human beings have a certain number of benign cutaneous neoplasms and many never seek medical attention. There is a dearth of information regarding the frequency of these tumors. The aim of this study was to record the number of benign tumors studied at the Dermatology Department of a medical facility., Material and Methods: A retrospective study analyzed medical records between 2000 and 2006. We included year of admission, number of biopsies, sex, age, tumor location, histological and clinical diagnoses., Results: We analyzed 9,436 biopsies of which 3,765 constituted benign neoplasms; 595 were not included and our total sample was 3,170 tumors. The most frequent tumors according to histopathological diagnoses in descending order were: melanocytic, cutaneous cysts, fibrous tumors, vascular tumors, epidermal tumors, fat tumors, tumors with hair differentiation, neural tumors, glandular tumors, tumors with sebaceous differentiation, cartilage and bone tumors, and smooth muscle tumors. The most common benign tumors were: Melanocytic nevi, epidermal cysts, seborrheic keratoses, pyogenic granulomas, lipomas and dermatofibromas., Conclusions: Melanocytes represented by melanocytic nevi (junctional, intradermic and compound) were the most frequent benign neoplasms, followed by epidermoid cysts. Our results illustrate the most common benign tumors observed in a dermatology department.
- Published
- 2007
34. [Giant gravidarum granuloma of the scalp].
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Domínguez-Cherit J, Puebla-Miranda M, Rangel-Gamboa L, and Roldán-Marín R
- Subjects
- Adult, Female, Granuloma, Pyogenic surgery, Humans, Pregnancy, Scalp pathology, Scalp surgery, Skin Diseases surgery, Treatment Outcome, Granuloma, Pyogenic pathology, Skin Diseases pathology
- Abstract
Lobular capillary hemangioma (pyogenic granuloma) has been reported more frequently in the skin (88%) than in the mucous membranes (12%). Granuloma gravidarum is a pyogenic granuloma that develops during pregnancy, often in the oral mucosa. Estrogens apparently increase the inflammatory response of mucous membranes. In this article, we describe the first case of a granuloma gravidarum of the scalp.
- Published
- 2006
35. Hip ulcer secondary to foreign body reaction and vacuum-assisted closure therapy: report of a case.
- Author
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Moreno-Coutiño G, Estrada-Chávez G, and Domínguez-Cherit J
- Subjects
- Adult, Follow-Up Studies, Foreign-Body Reaction chemically induced, Foreign-Body Reaction surgery, Humans, Injections, Subcutaneous adverse effects, Male, Mineral Oil administration & dosage, Mineral Oil adverse effects, Skin Ulcer surgery, Suction methods, Wound Healing, Foreign-Body Reaction complications, Hip, Skin Ulcer etiology
- Abstract
Patients who have a foreign body reaction are at risk of developing chronic ulcers secondary to necrosis, due to the inflammation present in the affected tissues or trauma, worsened by alterations in the vascular perfusion. These ulcers represent a therapeutic challenge for both physicians and patients.
- Published
- 2005
- Full Text
- View/download PDF
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