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1. Healthcare Professionals’ Attitudes toward Rapid Whole Genome Sequencing in Pediatric Acute Care

Author

Franck, Linda S, Scheurer-Monaghan, Andrea, Bupp, Caleb P, Fakhoury, Joseph D, Hoffmann, Thomas J, Deshpandey, Manasi, Arenchild, Madison, and Dimmock, David P

Subjects
Health Services and Systems, Biomedical and Clinical Sciences, Health Sciences, Clinical Research, Pediatric, Generic health relevance, Good Health and Well Being, genetics, genomics, pediatrics, hospital medicine, medical technology and advancement, Paediatrics, Public health
Abstract

We aimed to characterize knowledge and attitudes about rapid whole genome sequencing (rWGS) implementation of a broad constituency of healthcare professionals at hospitals participating in a statewide initiative to implement rWGS for hospitalized neonates and children up to 18 years of age meeting clinical criteria for testing. We surveyed 307 healthcare professionals from eight hospitals about their knowledge and attitudes regarding rWGS. We examined survey internal reliability using exploratory factor analysis and associations between respondent characteristics and attitudes toward rWGS with linear regression. We thematically analyzed free-text responses. Views about rWGS implementation in respondents' own setting and respondents' personal capability to implement rWGS were generally neutral (M = 3.44 (SD = 0.74); M = 3.30 (SD = 0.85), respectively). Views about the potential for rWGS in clinical practice were overall positive (M = 4.12 (SD = 0.57)). The degree of positivity of attitudes about rWGS was strongly influenced by perceived knowledge, clinical or non-clinical role, concerns about future insurance coverage for rWGS as a first-tier test, and future adverse impact of genomics health information on patients or families. We identified several actionable factors influencing attitudes toward rWGS of pediatric healthcare professionals. Expanded education and ongoing implementation research are needed for the full potential of rWGS in pediatrics to be realized.

Published
2022

2. Causal Bulk Viscous LRS Bianchi I Models With Variable Gravitational and Cosmological 'Constant'

Author

Pradhan, Anirudh, Pandey, Purnima, Singh, G. P., and Deshpandey, R. V.

Subjects
General Relativity and Quantum Cosmology
Abstract

In this paper we have investigated an LRS Bianchi I anisotropic cosmological model of the universe by taking time varying $G$ and $\Lambda$ in the presence of bulk viscous fluid source described by full causal non-equilibrium thermodynamics. We obtain a cosmological constant as a decreasing function of time and for $m, n > 0$, the value of cosmological ``constant'' for this model is found to be small and positive which is supported by the results from recent supernovae observations., Comment: 9 pages, LaTex, typos added

Published
2003

3. Healthcare Professionals’ Attitudes toward Rapid Whole Genome Sequencing in Pediatric Acute Care

Author

Linda S. Franck, Andrea Scheurer-Monaghan, Caleb P. Bupp, Joseph D. Fakhoury, Thomas J. Hoffmann, Manasi Deshpandey, Madison Arenchild, and David P. Dimmock

Subjects
genetics, genomics, pediatrics, hospital medicine, medical technology and advancement, Pediatrics, RJ1-570
Abstract

We aimed to characterize knowledge and attitudes about rapid whole genome sequencing (rWGS) implementation of a broad constituency of healthcare professionals at hospitals participating in a statewide initiative to implement rWGS for hospitalized neonates and children up to 18 years of age meeting clinical criteria for testing. We surveyed 307 healthcare professionals from eight hospitals about their knowledge and attitudes regarding rWGS. We examined survey internal reliability using exploratory factor analysis and associations between respondent characteristics and attitudes toward rWGS with linear regression. We thematically analyzed free-text responses. Views about rWGS implementation in respondents’ own setting and respondents’ personal capability to implement rWGS were generally neutral (M = 3.44 (SD = 0.74); M = 3.30 (SD = 0.85), respectively). Views about the potential for rWGS in clinical practice were overall positive (M = 4.12 (SD = 0.57)). The degree of positivity of attitudes about rWGS was strongly influenced by perceived knowledge, clinical or non-clinical role, concerns about future insurance coverage for rWGS as a first-tier test, and future adverse impact of genomics health information on patients or families. We identified several actionable factors influencing attitudes toward rWGS of pediatric healthcare professionals. Expanded education and ongoing implementation research are needed for the full potential of rWGS in pediatrics to be realized.

Published
2022
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4. Preventive strategies and factors associated with surgically treated necrotising enterocolitis in extremely preterm infants: an international unit survey linked with retrospective cohort data analysis

Author

Dirk Bassler, Kei Lui, Michael Dunn, Victor Samuel Rajadurai, Mikael Norman, Alejandro Avila-Alvarez, Marc Beltempo, Mark Adams, Barbara Bajuk, Malcolm Battin, Jean-François Tolsa, Ruben Alvaro, Chuks Nwaesei, Martine Claveau, Shoo K Lee, Prakesh S Shah, Zenon Cieslak, Rebecca Sherlock, Wendy Yee, Carlos Fajardo, Zarin Kalapesi, Koravangattu Sankaran, Mary Seshia, Amit Mukerji, Orlando Da Silva, Kyong-Soon Lee, Brigitte Lemyre, Kimberly Dow, Ermelinda Pelausa, Keith Barrington, Christine Drolet, Bruno Piedboeuf, Valerie Bertelle, Edith Masse, Roderick Canning, Hala Makary, Cecil Ojah, Luis Monterrosa, Jehier Afifi, Andrzej Kajetanowicz, lex Doyle, Roland Broadbent, Ross Haslam, Peter Marshall, Peter Schmidt, Paul Craven, Koert De Waal, Karen Simmer, Andy Gill, Jacqueline Stack, Dan Casalaz, Jim Holberton, Lucy Cooke, Lyn Downe, Michael Stewart, Andrew Berry, Rod Hunt, Charles Kilburn, Tony De Paoli, Mary Paradisis, Ingrid Rieger, Pieter Koorts, Carl Kuschel, Andrew Numa, Hazel Carlisle, Nadia Badawi, Guan Koh, Melissa Luig, Chad Andersen, Adrienne Lynn, Brian Darlow, Lindsay Mildenhall, Mariam Buksh, David Bourchier, Vaughan Richardson, Georgina Chambers, Robert Halliday, Thomas Riedel, Anne Synnes, Amir Kugelman, W Coroleu, Liisa Lehtonen, Brian A Darlow, Brian Reichman, Stellan Hakansson, Kjell K Helenius, Laura San Feliciano, Maximo Vento, Marco Moroni, Junmin Yang, Adam Buckmaster, Charles Barfield, Vijay Shingde, Shelley Reid, David Cartwright, Steven Resnick, Jutta van den Boom, Lee Carpenter, Adele Harrison, Khalid Aziz, Akhil Deshpandey, Sture Andersson, Outi Tammela, Ulla Sankilampi, Timo Saarela, Eli Heymann, Shmuel Zangen, Tatyana Smolkin, Francis Mimouni, David Bader, Avi Rothschild, Zipora Strauss, Clari Felszer, Hussam Omari, Smadar Even Tov-Friedman, Benjamin Bar-Oz, Michael Feldman, Nizar Saad, Orna Flidel-Rimon, Meir Weisbrod, Daniel Lubin, Ita Litmanovitz, Eric Shinwell, Gil Klinger, Yousif Nijim, Alona Bin-Nun, Agneta Golan, Dror Mandel, Vered Fleisher-Sheffer, David Kohelet, Lev Bakhrakh, José Luis Fernandez-Trisac, Ma Luz Couce Pico, María José Fernández Seara, Andrés Martínez Gutiérrez, Carolina Vizcaíno, Miriam Salvador Iglesias, Honorio Sánchez Zaplana, Belén Fernández Colomer, José Enrique García López, M Rafael García Mozo, Teresa González Martínez, Mª Dolores Muro Sebastián, Marta Balart Carbonell, Joan Badia Barnusell, Mònica Domingo Puiggròs, Corporacio Parc Taulí, Josep Figueras Aloy, Francesc Botet Mussons, Israel Anquela Sanz, Gemma Ginovart Galiana, Martin Iriondo, Laura Castells Vilella, Roser Porta, Xavier Demestre, Silvia Martínez Nadal, Cristina de Frutos Martínez, María Jesús López Cuesta, Dolores Esquivel Mora, Joaquín Ortiz Tardío, Isabel Benavente, Almudena Alonso, Ramón Aguilera Olmos, Miguel A García Cabezas, Mª Dolores Martínez Jiménez, Mª Pilar Jaraba Caballero, Mª Dolores Ordoñez Díaz, Alberto Trujillo Fagundo, Lluis Mayol Canals, Fermín García-Muñoz Rodrigo, Lourdes Urquía Martí, María Fernanda Moreno Galdo, José Antonio Hurtado Suazo, Eduardo Narbona López, José Uberos Fernández, Miguel A Cortajarena Altuna, Oihana Muga, David Mora Navarro, María Teresa Domínguez, Mª Yolanda Ruiz del Prado, Inés Esteban Díez, María Teresa Palau Benavides, Santiago Lapeña, Teresa Prada, Eduard Soler Mir, Araceli Corredera Sánchez, Enrique Criado Vega, Náyade del Prado, Cristina Fernández, Lucía Cabanillas Vilaplana, Irene Cuadrado Pérez, Luisa López Gómez, Laura Domingo Comeche, Isabel Llana Martín, Carmen González Armengod, Carmen Muñoz Labián, Mª José Santos Muñoz, Dorotea Blanco Bravo, Vicente Pérez, Mª Dolores Elorza Fernández, Celia Díaz González, Susana Ares Segura, Manuela López Azorín, Ana Belén Jimenez, Tomás Sánchez-Tamayo, Elías Tapia Moreno, María González, Beatriz Vacas del Arco, Josefina Márquez Fernández, Laura Acosta Gordillo, Mercedes Granero Asensio, Carmen Macías Díaz, Mar Albújar, Pedro Fuster Jorge, Sabina Romero, Ana Belén Escobar Izquierdo, Javier Estañ Capell, Mª Isabel Izquierdo Macián, Mª Mar Montejo Vicente, Raquel Izquierdo Caballero, Mª Mercedes Martínez, Aintzane Euba, Amaya Rodríguez Serna, Juan María López de Heredia Goya, Alberto Pérez Legorburu, Ana Gutiérrez Amorós, Víctor Manuel Marugán Isabel, Natalio Hernández González, Segundo Rite Gracia, Mª Purificación Ventura Faci, Mª Pilar Samper Villagrasa, Jiri Kofron, Katarina Strand Brodd, Andreas Odlind, Lars Alberg, Sofia Arwehed, Ola Hafström, Anna Kasemo, Karin Nederman, Lars Åhman, Fredrik Ingemarsson, Henrik Petersson, Pernilla Thurn, Eva Albinsson, Bo Selander, Thomas Abrahamsson, Ingela Heimdahl, Kristbjorg Sveinsdottir, Erik Wejryd, Anna Hedlund, Maria Katarina Söderberg, Boubou Hallberg, Thomas Brune, Jens Bäckström, Johan Robinson, Aijaz Farooqi, Erik Normann, Magnus Fredriksson, Anders Palm, Urban Rosenqvist, Bengt Walde, Cecilia Hagman, Andreas Ohlin, Rein Florell, Agneta Smedsaas-Löfvenberg, Philipp Meyer, Claudia Anderegg, Sven Schulzke, Mathias Nelle, Bendicht Wagner, Grégoire Kaczala, Riccardo E Pfister, Matthias Roth, Martin Stocker, Bernhard Laubscher, Andreas Malzacher, John P Micallef, Lukas Hegi, Romaine Arlettaz, Carlo Dani, Patrizio Fiorini, Paolo Ghirri, Barbara Tomasini, and Franca Rusconi

Subjects
Medicine
Abstract

Objectives To compare necrotising enterocolitis (NEC) prevention practices and NEC associated factors between units from eight countries of the International Network for Evaluation of Outcomes of Neonates, and to assess their association with surgical NEC rates.Design Prospective unit-level survey combined with retrospective cohort study.Setting Neonatal intensive care units in Australia/New Zealand, Canada, Finland, Israel, Spain, Sweden, Switzerland and Tuscany (Italy).Patients Extremely preterm infants born between 240 to 286 weeks’ gestation, with birth weights

Published
2019
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5. Biological Principles of Orthodontic Tooth Movement: A Review Article

Author

Rizwan Gilani, Priyanka Niranjane, Pallavi Daigavane, Mihika Deshpandey, Purva Dhannawat, R. H. Kamble, and Manya Sonkar

Subjects
stomatognathic diseases, stomatognathic system
Abstract

Orthodontic tooth mobility is discussed in this article, and the numerous concepts or theories of movement of tooth and the phases through which a tooth undergoes after application of forces. The effect of orthodontic pressure exerted on the dental architecture promotes movement of tooth through remodeling, which is the growth and resorption of alveolar bone. These forces can either be light forces or heavy forces depending upon their magnitudes. Biological aspects of tooth movement changes in accordance with the magnitude, force, time span and direction of force exerted. Variations in force application can be decided based on the kind of movement of tooth desired. These forces result in complex physiological events, cellular events in the surrounding tissues and, release of various chemical mediators to re-establish the equilibrium which gets interrupted by applying forces. Recently, many researches are going on how to enhance the speed of movement of the tooth with light forces so as to reduce the damage caused by the heavy forces, reduce the treatment time overall and treatment planning which results in minimal adverse effects.

Published
2021
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6. Effect of sandblasting on fracture load of titanium ceramic crowns

Author

Arvind I Moldi, Kishor Singh Bhandari, Sharanbassapa Nagral, Sumit Deshpandey, and Pawan Kulkarni

Subjects
Bonding, fracture load, sandblasting, titanium, Dentistry, RK1-715
Abstract

Purpose of the Study: It is difficult to achieve a reliable bond between the titanium and veneering porcelain. The aim of this study was to evaluate the bond strength between titanium ceramic crowns. Materials and Methods: The surfaces of titanium copings were divided in two groups. Group A sandblasted with 250 um (n = 10) and Group B without sandblasting (n = 10). Low-fusing porcelain was bonded over copings. A universal testing machine was used to determine the fracture load (N) of the crowns. All data were compared using Student′s t-test. Results: There was a significant difference in fracture toughness between two groups (P = 0.05). The mean value of fracture strength for Group A was 721.66 N and for Group B was 396.39 N. Conclusions: Sandblasting improves the bond strength between titanium, and ceramic, mechanical bonding plays a crucial role in the bonding between titanium and ceramic.

Published
2015
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7. Evaluation of transport-related outcomes for neonatal transport teams with and without physicians

Author

Louis Beaumier, Sumesh Thomas, Jennifer Toye, Thérèse Perrault, Paul Byrne, William Bingham, Michael Narvey, Geneviève Piuze, Akhil Deshpandey, Don Ilodigwe, Avash Singh, Gregory Hansen, Poornima Murthy, Zarin Kalapesi, Krista Jangaard, Joseph Ting, Ernesto Phillips, Kyong-Soon Lee, Michael Marrin, Stephanie Redpath, Anne Tierney, Henry Roukema, Mohamed Abdelmawla, Hilary Whyte, Rebecca Caces, Edith Masse, and Sibasis Daspal

Subjects
03 medical and health sciences, medicine.medical_specialty, 0302 clinical medicine, business.industry, 030225 pediatrics, Pediatrics, Perinatology and Child Health, Emergency medicine, Medicine, 030212 general & internal medicine, Online Only Original Articles, business, Neonatal transport, 3. Good health
Abstract

Objective The aim of this study was to evaluate if the presence of a physician in the neonatal transport team (NTT) affects transport-related outcomes and procedural success. Design Retrospective cohort study with propensity score matching. Setting Canadian national study. Patients Neonatal transports from nontertiary centres between January 2014 and December 2017. Interventions Comparison of transports conducted by NTTs with physicians (MD Group) and without physicians (noMD Group). Main outcome measures The primary outcome was the change in patient acuity as measured by the transport risk index of physiologic severity (TRIPS) score. Secondary outcomes included mortality within 24 hours of NICU admission, clinical complications during transport, procedural success, and stabilization time. Results Among 9,703 eligible cases, 899 neonatal transports attended by NTTs with physicians were compared to 899 neonatal transports without physicians using propensity score matching. No differences were seen in the improvement of TRIPS score or mortality ≤24 hours of NICU admission. The MD Group had more clinical complications (7.7% versus 5.0%, P=0.02). No differences were seen in success rates of invasive procedures. The MD Group had shorter stabilization times. In multivariable analysis, the MD Group was not a significant predictor for the improvement in TRIPS score after adjustment for covariates. Conclusions Neonatal transports conducted by teams including physicians compared to teams without physicians, did not have higher improvement in TRIPS scores and had similar success rates for procedures. These results provide insights for the planning of the structure and training of specialized interfacility neonatal transport programs.

Published
2021
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8. Study of ECG changes in Covid 19 patients.

Author

Baghel, AnkurSingh, Deshpandey, Rajesh, VipinPorwal, and Dubey, Amit

Subjects
*SARS-CoV-2, *COVID-19, *CORONAVIRUS diseases
Abstract

The article discusses research which observed electrocardiogram (ECG) changes in Covid-19 patients during hospitalization. The study examined the association of comorbidities including diabetes mellitus (DM), hypertension (HTN) and thyroid disease with mortality, between age and mortality, ECG abnormality among Covid-19 cases, and association between ECG and QT changes.

Published
2023

9. ADOLESCENTS COMMUNICATING DISTRESS THROUGH SUICIDAL BEHAVIORS

Author

Poonam Singh, Dorothy Sengupta, and Ujjwala Deshpandey

Subjects
Adolescents, suicidal behavior, factors, Medicine
Abstract

Background: Different risk factors associated with adolescent suicide attempts have been identified across the globe. Relatively few Indian studies are available on this data. Aims: To study the sociodemographic and clinical variables associated with adolescent suicide attempts. Setting and design: tertiary care hospital, retrospective descriptive study. Materials and methods: Participants: - ninety four patients admitted in the pediatric units who had attempted suicide by ingestion. A pretested, semi-open-ended questionnaire was filled for each patient. This data was then compiled and analyzed using statistical methods. Results: Among a total of 94 cases, sociodemographic patient risk factors found were:- male to female ratio is 1:3.5. Mean age found was 14.64 years. 58.5% were in age of 15 - 18 yrs., 54.9% were unemployed and 43.6% were educated only till middle school. Nuclear families with family members more than 5, siblings more than 3, a lower income class, single parents (10.6%), broken homes (9.6%), a history of suicide and alcoholism in family (9.6%) were found as familial risk factors associated with suicide attempts. The interpersonal problems (29%) and depression (19.1%) were the important psychological risk factors. Period prevalence was ≈1 per 1000. Case fatality rate was found to be 2.12 Conclusion: The adolescents used the method of deliberate self-harm only to get attention and had no intention of really dying. This was the distress call used by these adolescents.

Published
2015

10. Sustained quality improvement in outcomes of preterm neonates with a gestational age less than 29 weeks: results from the Evidence-based Practice for Improving Quality Phase 3

Author

Vibhuti Shah, Khorshid Mohammad, Akhil Deshpandey, Nely Amaral, Eugene Ng, Wendy Yee, Prakesh S. Shah, Xiang Y. Ye, Cindy Ulrich, Brigitte Lemyre, Khalid Aziz, Anne Synnes, Bruno Piedboeuf, Shoo K. Lee, Amit Mukerji, and Michael Dunn

Subjects
Male, Canada, medicine.medical_specialty, Evidence-based practice, Quality management, Physiology, media_common.quotation_subject, Gestational Age, 03 medical and health sciences, 0302 clinical medicine, 030225 pediatrics, Physiology (medical), medicine, Humans, Quality (business), Prospective Studies, 030212 general & internal medicine, Neonatology, Intensive care medicine, media_common, Pharmacology, business.industry, Infant, Newborn, Gestational age, General Medicine, medicine.disease, Quality Improvement, Neonatal outcomes, Evidence-Based Practice, Necrotizing enterocolitis, Female, business, Infant, Premature
Abstract

Quality improvement initiatives in neonatology have yielded positive results; however, few programs have demonstrated sustainability. We evaluated an ongoing, national quality improvement initiative (Evidence-based Practice for Improving Quality Phase 3 (EPIQ-3)) on outcomes of preterm neonates with a gestational age (GA) of 220–286weeks (i.e., from 22 weeks and 0 days of gestation to 28 weeks and 6 days of gestation). Data from 7459 neonates admitted to 25 Canadian centers between 2013 and 2017 were studied. Trends in mortality and major morbidities were evaluated. The number of neonates with a GA of 220–236weeks increased from 90 in 2013 to 139 in 2017 without a significant change in any other GA categories. In the entire cohort, the odds of composite outcome of mortality or any major morbidity (adjusted odds ratio (AOR) 0.72, 95% confidence interval (CI) 0.61–0.84) and of necrotizing enterocolitis (AOR 0.66, 95% CI 0.49–0.89) were lower in 2017 than in 2013. When calculated per year, the odds of composite outcome (AOR 0.93, 95% CI 0.89–0.97) and odds of necrotizing enterocolitis (AOR 0.89, 95% CI 0.82–0.96) decreased significantly. Among the subgroup of neonates with a GA of 260–286weeks, the odds of composite outcome (AOR 0.63, 95% CI 0.51–0.79), necrotizing enterocolitis (AOR 0.44, 95% CI 0.26–0.73), and nosocomial infection (AOR 0.64, 95% CI 0.49–0.84) were reduced. The collaborative, multidisciplinary, nationwide EPIQ-3 program improved outcomes of preterm neonates, and the improvement was sustainable over 5 years.

Published
2019
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11. Neonatal Outcomes in Very Preterm Infants With Severe Congenital Heart Defects : An International Cohort Study

Author

Mikael Norman, Stellan Håkansson, Satoshi Kusuda, Maximo Vento, Liisa Lehtonen, Brian Reichman, Brian A. Darlow, Mark Adams, Dirk Bassler, Tetsuya Isayama, Franca Rusconi, Shoo Lee, Kei Lui, Junmin Yang, Prakesh S. Shah, Peter Marshall, Peter Schmidt, Anjali Dhawan, Paul Craven, Koert de Waal, Karen Simmer, Andy Gill, Jane Pillow, Jacqueline Stack, Pita Birch, Lucy Cooke, Dan Casalaz, Jim Holberton, Alice Stewart, Lyn Downe, Michael Stewart, Barbara Bajuk, Andrew Berry, Rod Hunt, Charles Kilburn, Tony De Paoli, Srinivas Bolisetty, Mary Paradisis, Ingrid Rieger, Pieter Koorts, Carl Kuschel, Lex Doyle, Andrew Numa, Hazel Carlisle, Nadia Badawi, Alison Loughran‐Fowlds, Guan Koh, Jonathan Davis, Melissa Luig, Chad Andersen, Georgina Chambers, Nicola Austin, Adrienne Lynn, Brian Darlow, Liza Edmonds, Lindsay Mildenhall, Mariam Buksh, Malcolm Battin, Jutta van den Boom, David Bourchier, Vaughan Richardson, Fiona Dineen, Victor Samuel Rajadurai, Simon Lam, Genevieve Fung, Adele Harrison, Anne Synnes, Joseph Ting, Zenon Cieslak, Rebecca Sherlock, Wendy Yee, Khalid Aziz, Jennifer Toye, Carlos Fajardo, Zarin Kalapesi, Koravangattu Sankaran, Sibasis Daspal, Mary Seshia, Ruben Alvaro, Amit Mukerji, Orlando Da Silva, Chuks Nwaesei, Kyong‐Soon Lee, Michael Dunn, Brigitte Lemyre, Kimberly Dow, Ermelinda Pelausa, Keith Barrington, Christine Drolet, Bruno Piedboeuf, Martine Claveau, Marc Beltempo, Valerie Bertelle, Edith Masse, Roderick Canning, Hala Makary, Cecil Ojah, Luis Monterrosa, Akhil Deshpandey, Jehier Afifi, Andrzej Kajetanowicz, Shoo K. Lee, Sture Andersson, Outi Tammela, Ulla Sankilampi, Timo Saarela, Eli Heymann, Shmuel Zangen, Tatyana Smolkin, Francis Mimouni, David Bader, Avi Rothschild, Zipora Strauss, Clari Felszer, Hussam Omari, Smadar Even Tov‐Friedman, Benjamin Bar‐Oz, Michael Feldman, Nizar Saad, Orna Flidel‐Rimon, Meir Weisbrod, Daniel Lubin, Ita Litmanovitz, Amir Kugelman, Eric Shinwell, Gil Klinger, Yousif Nijim, Alona Bin‐Nun, Agneta Golan, Dror Mandel, Vered Fleisher‐Sheffer, David Kohelet, Lev Bakhrakh, Satoshi Hattori, Masaru Shirai, Toru Ishioka, Toshihiko Mori, Takasuke Amizuka, Toru Huchimukai, Hiroshi Yoshida, Ayako Sasaki, Junichi Shimizu, Toshihiko Nakamura, Mami Maruyama, Hiroshi Matsumoto, Shinichi Hosokawa, Atsuko Taki, Machiko Nakagawa, Kyone Ko, Azusa Uozumi, Setsuko Nakata, Akira Shimazaki, Tatsuya Yoda, Osamu Numata, Hiroaki Imamura, Azusa Kobayashi, Shuko Tokuriki, Yasushi Uchida, Takahiro Arai, Mitsuhiro Ito, Kuniko Ieda, Toshiyuki Ono, Masashi Hayashi, Kanemasa Maki, MieToru Yamakawa, Masahiko Kawai, Noriko Fujii, Kozue Shiomi, Koji Nozaki, Hiroshi Wada, Taho Kim, Yasuyuki Tokunaga, Akihiro Takatera, Toshio Oshima, Hiroshi Sumida, Yae Michinomae, Yoshio Kusumoto, Seiji Yoshimoto, Takeshi Morisawa, Tamaki Ohashi, Yukihiro Takahashi, Moriharu Sugimoto, Noriaki Ono, Shinichiro Miyagawa, Takahiko Saijo, Takashi Yamagami, Kosuke Koyano, Shoko Kobayashi, Takeshi Kanda, Yoshihiro Sakemi, Mikio Aoki, Koichi Iida, Mitsushi Goshi, Yuko Maruyama, Alejandro Avila‐Alvarez, José Luis Fernandez‐Trisac, Mª Luz Couce Pico, María José Fernández Seara, Andrés Martínez Gutiérrez, Carolina Vizcaíno, Miriam Salvador Iglesias, Honorio Sánchez Zaplana, Belén Fernández Colomer, José Enrique García López, Rafael García Mozo, M. Teresa González Martínez, Mª Dolores Muro Sebastián, Marta Balart Carbonell, Joan Badia Barnusell, Mònica Domingo Puiggròs, Corporacio Parc Taulí, Josep Figueras Aloy, Francesc Botet Mussons, Israel Anquela Sanz, Gemma Ginovart Galiana, H. De La Santa, W. Coroleu, Martin Iriondo, Laura Castells Vilella, Roser Porta, Xavier Demestre, Silvia Martínez Nadal, Cristina de Frutos Martínez, María Jesús López Cuesta, Dolores Esquivel Mora, Joaquín Ortiz Tardío, Isabel Benavente, Almudena Alonso, Ramón Aguilera Olmos, Miguel A. García Cabezas, Mª Dolores Martínez Jiménez, Mª Pilar Jaraba Caballero, Mª Dolores Ordoñez Díaz, Alberto Trujillo Fagundo, Lluis Mayol Canals, Fermín García‐Muñoz Rodrigo, Lourdes Urquía Martí, María Fernanda Moreno Galdo, José Antonio Hurtado Suazo, Eduardo Narbona López, José Uberos Fernández, Miguel A. Cortajarena Altuna, Oihana Muga Zuriarrain, David Mora Navarro, María Teresa Domínguez, Mª Yolanda Ruiz del Prado, Inés Esteban Díez, María Teresa Palau Benavides, Santiago Lapeña, Teresa Prada, Eduard Soler Mir, Araceli Corredera Sánchez, Enrique Criado Vega, Náyade del Prado, Cristina Fernández, Lucía Cabanillas Vilaplana, Irene Cuadrado Pérez, Luisa López Gómez, Laura Domingo Comeche, Isabel Llana Martín, Carmen González Armengod, Carmen Muñoz Labián, Mª José Santos Muñoz, Dorotea Blanco Bravo, Vicente Pérez, Mª Dolores Elorza Fernández, Celia Díaz González, Susana Ares Segura, Manuela López Azorín, Ana Belén Jimenez MD, Tomás Sánchez‐Tamayo, Elías Tapia Moreno, María González, José Enrique Sánchez Martínez, José María Lloreda García, Concepción Goñi Orayen, Javier Vilas González, María Suárez Albo, Eva González Colmenero, Elena Pilar Gutiérrez González, Beatriz Vacas del Arco, Josefina Márquez Fernández, Laura Acosta Gordillo, Mercedes Granero Asensio, Carmen Macías Díaz, Mar Albújar, Pedro Fuster Jorge, Sabina Romero, Mónica Rivero Falero, Ana Belén Escobar Izquierdo, Javier Estañ Capell, Mª Isabel Izquierdo Macián, Mª Mar Montejo Vicente, Raquel Izquierdo Caballero, Mª Mercedes Martínez, Aintzane Euba, Amaya Rodríguez Serna, Juan María López de Heredia Goya, Alberto Pérez Legorburu, Ana Gutiérrez Amorós, Víctor Manuel Marugán Isabel, Natalio Hernández González, Segundo Rite Gracia, Mª Purificación Ventura Faci, Mª Pilar Samper Villagrasa, Jiri Kofron, Katarina Strand Brodd, Andreas Odlind, Lars Alberg, Sofia Arwehed, Ola Hafström, Anna Kasemo, Karin Nederman, Lars Åhman, Fredrik Ingemarsson, Henrik Petersson, Pernilla Thurn, Eva Albinsson, Bo Selander, Thomas Abrahamsson, Ingela Heimdahl, Kristbjorg Sveinsdottir, Erik Wejryd, Anna Hedlund, Maria Katarina Söderberg, Lars Navér, Thomas Brune, Jens Bäckström, Johan Robinson, Aijaz Farooqi, Erik Normann, Magnus Fredriksson, Anders Palm, Urban Rosenqvist, Bengt Walde, Cecilia Hagman, Andreas Ohlin, Rein Florell, Agneta Smedsaas‐Löfvenberg, Philipp Meyer, Rachel Kusche, Sven Schulzke, Mathias Nelle, Bendicht Wagner, Thomas Riedel, Grégoire Kaczala, Riccardo E. Pfister, Jean‐François Tolsa, Matthias Roth, Martin Stocker, Bernhard Laubscher, Andreas Malzacher, John P. Micallef, Lukas Hegi, Romaine Arlettaz, Vera Bernet, Carlo Dani, Patrizio Fiorini, Paolo Ghirri, Barbara Tomasini, Tampere University, Department of Paediatrics, and Clinical Medicine

Subjects
Heart Defects, Congenital, Male, Pediatrics, medicine.medical_specialty, Epidemiology, Birth weight, Gestational Age, Infant, Premature, Diseases, 030204 cardiovascular system & hematology, 3121 Internal medicine, Cohort Studies, 03 medical and health sciences, 0302 clinical medicine, 030225 pediatrics, Developmental biology, Infant Mortality, cardiac malformation, Medicine, Humans, Hospital Mortality, Original Research, business.industry, Mortality rate, Congenital Heart Disease, Infant, Newborn, Gestational age, Pediatrik, preterm birth, Infant, Retinopathy of prematurity, Odds ratio, medicine.disease, mortality, Bronchopulmonary dysplasia, newborn infant, Infant, Extremely Premature, Necrotizing enterocolitis, Female, Mortality/Survival, Cardiology and Cardiovascular Medicine, business, Cohort study
Abstract

Background Very preterm infants are at high risk of death or severe morbidity. The objective was to determine the significance of severe congenital heart defects ( CHDs ) for these risks. Methods and Results This cohort study included infants from 10 countries born from 2007–2015 at 24 to 31 weeks’ gestation with birth weights CHDs were defined by International Classification of Diseases, Ninth Revision ( ICD‐9 ) and Tenth ( ICD‐10 ) codes and categorized as those compromising systemic output, causing sustained cyanosis, or resulting in congestive heart failure. The primary outcome was in‐hospital mortality. Secondary outcomes were neonatal brain injury, necrotizing enterocolitis, bronchopulmonary dysplasia, and retinopathy of prematurity. Adjusted and propensity score–matched odds ratios ( ORs ) were calculated. Analyses were stratified by type of CHD , gestational age, and network. A total of 609 (0.77%) infants had severe CHD and 76 371 without any malformation served as controls. The mean gestational age and birth weight were 27.8 weeks and 1018 g, respectively. The mortality rate was 18.6% in infants with CHD and 8.9% in controls (propensity score–matched OR , 2.30; 95% CI , 1.61–3.27). Severe CHD was not associated with neonatal brain injury, necrotizing enterocolitis, or retinopathy of prematurity, whereas the OR for bronchopulmonary dysplasia increased. Mortality was higher in all types, with the highest propensity score–matched OR (4.96; 95% CI, 2.11–11.7) for CHD causing congestive heart failure. While mortality did not differ between groups at OR for mortality in infants with CHD increased to 10.9 (95% CI, 5.76–20.70) at 31 weeks’ gestational age. Rates of CHD and mortality differed significantly between networks. Conclusions Severe CHD is associated with significantly increased mortality in very preterm infants.

Published
2020

12. Abstract P126: Comparing Cardiovascular Risk Factor Progression Between South Asian Men and Women With Diabetes: A Longitudinal Analysis From the Masala Study

Author

Chiung-Yu Huang, Namratha R. Kandula, Manasi Deshpandey, and Alka M. Kanaya

Subjects
medicine.medical_specialty, South asia, business.industry, Cvd risk, Incidence (epidemiology), Disease, Type 2 diabetes, medicine.disease, Physiology (medical), Internal medicine, Diabetes mellitus, medicine, cardiovascular diseases, Risk factor, Cardiology and Cardiovascular Medicine, business
Abstract

Introduction: South Asians have a high incidence of type 2 diabetes(DM) and cardiovascular disease (CVD). Women with DM may have greater CVD risk compared to men with DM and women without DM. No study has determined whether the incidence or progression of coronary artery calcium (CAC) score, a measure of atherosclerosis burden, differs between South Asian men and women with DM. Hypothesis: We hypothesize that CAC progression is greater in women with DM as compared to men with DM and women without DM. Methods: We used the data from the MASALA study, a community-based prospective cohort of South Asians from 2 clinical sites without CVD at baseline. We conducted a longitudinal analysis of diabetic participants who were reassessed after 5 years and compared with those without diabetes. We classified incident CAC as any CAC at exam 2 in a participant who had no CAC at baseline. To examine the progression of CVD risk factors over time, we compared change in CAC score, waist circumference, systolic and diastolic blood pressure, HbA1c and lipid levels amongst the diabetic and non-diabetic population by sex. We conducted multivariable linear regression models stratified by diabetes status to determine whether sex was independently associated with change in CAC score and other CVD risk factors. Results: Of 749 participants who were seen in follow-up, 176 (23%) had diabetes at baseline, 65% were men, and mean age was 58 years. Approximately 64% women with DM vs. 28% men with DM had CAC=0, and men had higher median CAC score (49 (IQR 0-247) vs. 0 (IQR 0-46, p Conclusion: In this South Asian population, change in CAC score was lower in women with DM than in men with DM, and was comparable to women without DM. These results suggest among South Asians with DM, overall CVD risk may be greater in men than in women.Continued follow-up of the MASALA cohort will determine whether there are sex differences in CVD outcomes.

Published
2020
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13. ANTHROPOMETRIC STUDY OF CEPHALIC INDEX OF GOND TRIBE AND NON-TRIBE BOYS OF MUNGELI DISTRICT, CHHATTISGARH STATE, INDIA

Author

R. N. Das, Sudha Deshpandey, Praveen Kumar Banjare, Medical officer, Chc Bhatapara, District Balodabajar-bhatapara , India, and Dharam Singh Rathia

Subjects
Embryology, 0404 agricultural biotechnology, Histology, Geography, Cephalic index, 04 agricultural and veterinary sciences, Cell Biology, Anatomy, Anthropometry, Tribe (biology), Socioeconomics, 040401 food science
Published
2018
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15. Neonatal Outcomes in Very Preterm Infants With Severe Congenital Heart Defects: An International Cohort Study

Author

Norman, Mikael, primary, Håkansson, Stellan, additional, Kusuda, Satoshi, additional, Vento, Maximo, additional, Lehtonen, Liisa, additional, Reichman, Brian, additional, Darlow, Brian A., additional, Adams, Mark, additional, Bassler, Dirk, additional, Isayama, Tetsuya, additional, Rusconi, Franca, additional, Lee, Shoo, additional, Lui, Kei, additional, Yang, Junmin, additional, Shah, Prakesh S., additional, Marshall, Peter, additional, Schmidt, Peter, additional, Dhawan, Anjali, additional, Craven, Paul, additional, de Waal, Koert, additional, Simmer, Karen, additional, Gill, Andy, additional, Pillow, Jane, additional, Stack, Jacqueline, additional, Birch, Pita, additional, Cooke, Lucy, additional, Casalaz, Dan, additional, Holberton, Jim, additional, Stewart, Alice, additional, Downe, Lyn, additional, Stewart, Michael, additional, Bajuk, Barbara, additional, Berry, Andrew, additional, Hunt, Rod, additional, Kilburn, Charles, additional, De Paoli, Tony, additional, Bolisetty, Srinivas, additional, Paradisis, Mary, additional, Rieger, Ingrid, additional, Koorts, Pieter, additional, Kuschel, Carl, additional, Doyle, Lex, additional, Numa, Andrew, additional, Carlisle, Hazel, additional, Badawi, Nadia, additional, Loughran‐Fowlds, Alison, additional, Koh, Guan, additional, Davis, Jonathan, additional, Luig, Melissa, additional, Andersen, Chad, additional, Chambers, Georgina, additional, Austin, Nicola, additional, Lynn, Adrienne, additional, Darlow, Brian, additional, Edmonds, Liza, additional, Mildenhall, Lindsay, additional, Buksh, Mariam, additional, Battin, Malcolm, additional, van den Boom, Jutta, additional, Bourchier, David, additional, Richardson, Vaughan, additional, Dineen, Fiona, additional, Rajadurai, Victor Samuel, additional, Lam, Simon, additional, Fung, Genevieve, additional, Harrison, Adele, additional, Synnes, Anne, additional, Ting, Joseph, additional, Cieslak, Zenon, additional, Sherlock, Rebecca, additional, Yee, Wendy, additional, Aziz, Khalid, additional, Toye, Jennifer, additional, Fajardo, Carlos, additional, Kalapesi, Zarin, additional, Sankaran, Koravangattu, additional, Daspal, Sibasis, additional, Seshia, Mary, additional, Alvaro, Ruben, additional, Mukerji, Amit, additional, Da Silva, Orlando, additional, Nwaesei, Chuks, additional, Lee, Kyong‐Soon, additional, Dunn, Michael, additional, Lemyre, Brigitte, additional, Dow, Kimberly, additional, Pelausa, Ermelinda, additional, Barrington, Keith, additional, Drolet, Christine, additional, Piedboeuf, Bruno, additional, Claveau, Martine, additional, Beltempo, Marc, additional, Bertelle, Valerie, additional, Masse, Edith, additional, Canning, Roderick, additional, Makary, Hala, additional, Ojah, Cecil, additional, Monterrosa, Luis, additional, Deshpandey, Akhil, additional, Afifi, Jehier, additional, Kajetanowicz, Andrzej, additional, Lee, Shoo K., additional, Andersson, Sture, additional, Tammela, Outi, additional, Sankilampi, Ulla, additional, Saarela, Timo, additional, Heymann, Eli, additional, Zangen, Shmuel, additional, Smolkin, Tatyana, additional, Mimouni, Francis, additional, Bader, David, additional, Rothschild, Avi, additional, Strauss, Zipora, additional, Felszer, Clari, additional, Omari, Hussam, additional, Tov‐Friedman, Smadar Even, additional, Bar‐Oz, Benjamin, additional, Feldman, Michael, additional, Saad, Nizar, additional, Flidel‐Rimon, Orna, additional, Weisbrod, Meir, additional, Lubin, Daniel, additional, Litmanovitz, Ita, additional, Kugelman, Amir, additional, Shinwell, Eric, additional, Klinger, Gil, additional, Nijim, Yousif, additional, Bin‐Nun, Alona, additional, Golan, Agneta, additional, Mandel, Dror, additional, Fleisher‐Sheffer, Vered, additional, Kohelet, David, additional, Bakhrakh, Lev, additional, Hattori, Satoshi, additional, Shirai, Masaru, additional, Ishioka, Toru, additional, Mori, Toshihiko, additional, Amizuka, Takasuke, additional, Huchimukai, Toru, additional, Yoshida, Hiroshi, additional, Sasaki, Ayako, additional, Shimizu, Junichi, additional, Nakamura, Toshihiko, additional, Maruyama, Mami, additional, Matsumoto, Hiroshi, additional, Hosokawa, Shinichi, additional, Taki, Atsuko, additional, Nakagawa, Machiko, additional, Ko, Kyone, additional, Uozumi, Azusa, additional, Nakata, Setsuko, additional, Shimazaki, Akira, additional, Yoda, Tatsuya, additional, Numata, Osamu, additional, Imamura, Hiroaki, additional, Kobayashi, Azusa, additional, Tokuriki, Shuko, additional, Uchida, Yasushi, additional, Arai, Takahiro, additional, Ito, Mitsuhiro, additional, Ieda, Kuniko, additional, Ono, Toshiyuki, additional, Hayashi, Masashi, additional, Maki, Kanemasa, additional, Yamakawa, MieToru, additional, Kawai, Masahiko, additional, Fujii, Noriko, additional, Shiomi, Kozue, additional, Nozaki, Koji, additional, Wada, Hiroshi, additional, Kim, Taho, additional, Tokunaga, Yasuyuki, additional, Takatera, Akihiro, additional, Oshima, Toshio, additional, Sumida, Hiroshi, additional, Michinomae, Yae, additional, Kusumoto, Yoshio, additional, Yoshimoto, Seiji, additional, Morisawa, Takeshi, additional, Ohashi, Tamaki, additional, Takahashi, Yukihiro, additional, Sugimoto, Moriharu, additional, Ono, Noriaki, additional, Miyagawa, Shinichiro, additional, Saijo, Takahiko, additional, Yamagami, Takashi, additional, Koyano, Kosuke, additional, Kobayashi, Shoko, additional, Kanda, Takeshi, additional, Sakemi, Yoshihiro, additional, Aoki, Mikio, additional, Iida, Koichi, additional, Goshi, Mitsushi, additional, Maruyama, Yuko, additional, Avila‐Alvarez, Alejandro, additional, Fernandez‐Trisac, José Luis, additional, Pico, Mª Luz Couce, additional, Fernández Seara, María José, additional, Gutiérrez, Andrés Martínez, additional, Vizcaíno, Carolina, additional, Salvador Iglesias, Miriam, additional, Zaplana, Honorio Sánchez, additional, Fernández Colomer, Belén, additional, García López, José Enrique, additional, Mozo, Rafael García, additional, Martínez, M. Teresa González, additional, Muro Sebastián, Mª Dolores, additional, Carbonell, Marta Balart, additional, Barnusell, Joan Badia, additional, Puiggròs, Mònica Domingo, additional, Taulí, Corporacio Parc, additional, Aloy, Josep Figueras, additional, Mussons, Francesc Botet, additional, Sanz, Israel Anquela, additional, Galiana, Gemma Ginovart, additional, De La Santa, H., additional, Coroleu, W., additional, Iriondo, Martin, additional, Castells Vilella, Laura, additional, Porta, Roser, additional, Demestre, Xavier, additional, Martínez Nadal, Silvia, additional, de Frutos Martínez, Cristina, additional, López Cuesta, María Jesús, additional, Mora, Dolores Esquivel, additional, Tardío, Joaquín Ortiz, additional, Benavente, Isabel, additional, Alonso, Almudena, additional, Aguilera Olmos, Ramón, additional, García Cabezas, Miguel A., additional, Martínez Jiménez, Mª Dolores, additional, Jaraba Caballero, Mª Pilar, additional, Ordoñez Díaz, Mª Dolores, additional, Fagundo, Alberto Trujillo, additional, Canals, Lluis Mayol, additional, Rodrigo, Fermín García‐Muñoz, additional, Martí, Lourdes Urquía, additional, Galdo, María Fernanda Moreno, additional, Suazo, José Antonio Hurtado, additional, López, Eduardo Narbona, additional, Fernández, José Uberos, additional, Cortajarena Altuna, Miguel A., additional, Muga Zuriarrain, Oihana, additional, Mora Navarro, David, additional, Domínguez, María Teresa, additional, del Prado, Mª Yolanda Ruiz, additional, Díez, Inés Esteban, additional, Palau Benavides, María Teresa, additional, Lapeña, Santiago, additional, Prada, Teresa, additional, Mir, Eduard Soler, additional, Sánchez, Araceli Corredera, additional, Vega, Enrique Criado, additional, del Prado, Náyade, additional, Fernández, Cristina, additional, Vilaplana, Lucía Cabanillas, additional, Pérez, Irene Cuadrado, additional, Gómez, Luisa López, additional, Comeche, Laura Domingo, additional, Martín, Isabel Llana, additional, González Armengod, Carmen, additional, Labián, Carmen Muñoz, additional, Santos Muñoz, Mª José, additional, Bravo, Dorotea Blanco, additional, Pérez, Vicente, additional, Fernández, Mª Dolores Elorza, additional, González, Celia Díaz, additional, Segura, Susana Ares, additional, Azorín, Manuela López, additional, MD, Ana Belén Jimenez, additional, Sánchez‐Tamayo, Tomás, additional, Moreno, Elías Tapia, additional, González, María, additional, Sánchez Martínez, José Enrique, additional, Lloreda García, José María, additional, Orayen, Concepción Goñi, additional, González, Javier Vilas, additional, Albo, María Suárez, additional, Colmenero, Eva González, additional, Gutiérrez González, Elena Pilar, additional, Vacas del Arco, Beatriz, additional, Fernández, Josefina Márquez, additional, Gordillo, Laura Acosta, additional, Asensio, Mercedes Granero, additional, Díaz, Carmen Macías, additional, Albújar, Mar, additional, Fuster Jorge, Pedro, additional, Romero, Sabina, additional, Falero, Mónica Rivero, additional, Escobar Izquierdo, Ana Belén, additional, Estañ Capell, Javier, additional, Izquierdo Macián, Mª Isabel, additional, Montejo Vicente, Mª Mar, additional, Caballero, Raquel Izquierdo, additional, Martínez, Mª Mercedes, additional, Euba, Aintzane, additional, Serna, Amaya Rodríguez, additional, de Heredia Goya, Juan María López, additional, Legorburu, Alberto Pérez, additional, Amorós, Ana Gutiérrez, additional, Isabel, Víctor Manuel Marugán, additional, González, Natalio Hernández, additional, Gracia, Segundo Rite, additional, Faci, Mª Purificación Ventura, additional, Villagrasa, Mª Pilar Samper, additional, Kofron, Jiri, additional, Strand Brodd, Katarina, additional, Odlind, Andreas, additional, Alberg, Lars, additional, Arwehed, Sofia, additional, Hafström, Ola, additional, Kasemo, Anna, additional, Nederman, Karin, additional, Åhman, Lars, additional, Ingemarsson, Fredrik, additional, Petersson, Henrik, additional, Thurn, Pernilla, additional, Albinsson, Eva, additional, Selander, Bo, additional, Abrahamsson, Thomas, additional, Heimdahl, Ingela, additional, Sveinsdottir, Kristbjorg, additional, Wejryd, Erik, additional, Hedlund, Anna, additional, Söderberg, Maria Katarina, additional, Navér, Lars, additional, Brune, Thomas, additional, Bäckström, Jens, additional, Robinson, Johan, additional, Farooqi, Aijaz, additional, Normann, Erik, additional, Fredriksson, Magnus, additional, Palm, Anders, additional, Rosenqvist, Urban, additional, Walde, Bengt, additional, Hagman, Cecilia, additional, Ohlin, Andreas, additional, Florell, Rein, additional, Smedsaas‐Löfvenberg, Agneta, additional, Meyer, Philipp, additional, Kusche, Rachel, additional, Schulzke, Sven, additional, Nelle, Mathias, additional, Wagner, Bendicht, additional, Riedel, Thomas, additional, Kaczala, Grégoire, additional, Pfister, Riccardo E., additional, Tolsa, Jean‐François, additional, Roth, Matthias, additional, Stocker, Martin, additional, Laubscher, Bernhard, additional, Malzacher, Andreas, additional, Micallef, John P., additional, Hegi, Lukas, additional, Arlettaz, Romaine, additional, Bernet, Vera, additional, Dani, Carlo, additional, Fiorini, Patrizio, additional, Ghirri, Paolo, additional, and Tomasini, Barbara, additional

Published
2020
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16. Rates and Determinants of Mother’s Own Milk Feeding in Infants Born Very Preterm

Author

Dinesh Dharel, Nalini Singhal, Christel Wood, Zenon Cieslak, Fabiana Bacchini, Prakesh S. Shah, Xiang Y. Ye, Belal Alshaikh, Haim Abenhaim, Jehier Afifi, Ruben Alvaro, James Andrews, Anthony Armson, Francois Audibert, Khalid Aziz, Marilyn Ballantyne, Jon Barrett, Marc Beltempo, Anick Berard, Valerie Bertelle, Lucie Blais, Alan Bocking, Jaya Bodani, Jason Burrows, Kimberly Butt, Roderick Canning, George Carson, Nils Chaillet, Sue Chandra, Paige Church, Kevin Coughlin, Joan Crane, Dianne Creighton, Orlando Da Silva, Thierry Daboval, Leanne Dahlgren, Sibasis Daspal, Cecilia de Cabo, Akhil Deshpandey, Kimberly Dow, Christine Drolet, Michael Dunn, Salhab el Helou, Darine El-Chaar, Walid El-Naggar, Carlos Fajardo, Jonathan Foster, Robert Gagnon, Rob Gratton, Victor Han, Adele Harrison, Shabih Hasan, Michael Helewa, Matthew Hicks, K.S. Joseph, Andrzej Kajetanowicz, Zarin Kalapesi, May Khairy, Thierry Lacaze-Masmonteil, Kyong-Soon Lee, Brigitte Lemyre, Abhay Lodha, Deepak Louis, Thuy Mai Luu, Linh Ly, Annette Majnemer, Hala Makary, Isabelle Marc, Edith Masse, Sarah D. McDonald, Doug McMillan, Nir Melamed, Amy Metcalfe, Diane Moddemann, Luis Monterrosa, Michelle Morais, Amit Mukerji, William Mundle, Lynn Murphy, Kellie Murphy, Anne-Monique Nuyt, Chuks Nwaesei, Karel O’Brien, Martin Offringa, Cecil Ojah, Annie Ouellet, Jean-Charles Pasquier, Petros Pechlivanoglou, Ermelinda Pelausa, Bruno Piedboeuf, Elodie Portales-Casamar, Shahirose Premji, Pramod Puligandla, Eleanor Pullenayegum, Amber Reichert, Carol Schneider, Mary Seshia, Vibhuti Shah, Rebecca Sherlock, Sandesh Shivananda, Erik Skarsgard, Amanda Skoll, Graeme Smith, Anne Synnes, Katherine Thériault, Joseph Ting, Suzanne Tough, Jennifer Toye, Jagdeep Ubhi, Michael Vincer, Wendy Whittle, Hilary Whyte, Doug Wilson, Stephen Wood, Philip Ye, Wendy Yee, and Jill Zwicker

Subjects
Adult, Canada, medicine.medical_specialty, Canadian Neonatal Network, Population, Mothers, Gestational Age, formula feeding, Breast milk, Pediatrics, Cohort Studies, Young Adult, 03 medical and health sciences, 0302 clinical medicine, Formula feeding, Intensive Care Units, Neonatal, 030225 pediatrics, medicine, Hospital discharge, Humans, 030212 general & internal medicine, education, education.field_of_study, premature infant [breast milk feeding], Milk, Human, Obstetrics, business.industry, Infant, Newborn, Gestational age, Infant Formula, Patient Discharge, Bottle Feeding, Very preterm, Breast Feeding, Logistic Models, Infant, Extremely Premature, Pediatrics, Perinatology and Child Health, Cohort, Female, business, Cohort study
Abstract

To examine rates and determinants of mother's own milk (MOM) feeding at hospital discharge in a cohort of infants born very preterm within the Canadian Neonatal Network (CNN).This was a population-based cohort study of infants born at33 weeks of gestation and admitted to neonatal intensive care units (NICUs) participating in the CNN between January 1, 2015, and December 31, 2018. We examined the rates and determinants of MOM use at discharge home among the participating NICUs. We used multivariable logistic regression analysis to identify independent determinants of MOM feeding.Among the 6404 infants born very preterm and discharged home during the study period, 4457 (70%) received MOM or MOM supplemented with formula. Rates of MOM feeding at discharge varied from 49% to 87% across NICUs. Determinants associated with MOM feeding at discharge were gestational age 29-32 weeks compared with26 weeks (aOR 1.56, 95% CI 1.25-1.93), primipara mothers (aOR 2.12, 95% CI 1.86-2.42), maternal diabetes (aOR 0.79, 95% CI 0.66-0.93), and maternal smoking (aOR 0.27, 95% CI 0.19-0.38). Receipt of MOM by day 3 of age was the major predictor of breast milk feeding at discharge (aOR 3.61, 95% CI 3.17-4.12).Approximately two-thirds of infants born very preterm received MOM at hospital discharge, and rates varied across NICUs. Supporting mothers to provide breast milk in the first 3 days after birth may be associated with improved MOM feeding rates at discharge.

Published
2021
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18. Outcomes and care practices for preterm infants born at less than 33 weeks’ gestation: A quality-improvement study

Author

Lee, Shoo K., Beltempo, Marc, McMillan, Douglas D., Seshia, Mary, Singhal, Nalini, Dow, Kimberly, Aziz, Khalid, Piedboeuf, Bruno, Shah, Prakesh S., Shah, Vibhuti, Synnes, Anne, Yee, Wendy, Ye, Xiang Y., Emberley, Julie, Deshpandey, Akhil, Afifi, Jehier, Makary, Hala, Canning, Roderick, Monterrosa, Luis, Drolet, Christine, Barrington, Keith, Lapointe, Anie, Pelausa, Ermelinda, Riley, Patricia, Perreault, Therese, Twiss, Jennifer, Mukerji, Amit, Shivananda, Sandesh, and Khurshid, Faiza

Subjects
Canada, Pediatrics, medicine.medical_specialty, Gestational Age, 03 medical and health sciences, 0302 clinical medicine, Pregnancy, 030225 pediatrics, Intensive care, Humans, Medicine, 030212 general & internal medicine, Child, Survival analysis, business.industry, Research, Infant, Newborn, Parturition, Infant, Gestational age, Retrospective cohort study, General Medicine, Odds ratio, Quality Improvement, Confidence interval, Population study, Gestation, Female, business, Infant, Premature
Abstract

BACKGROUND: Preterm birth is the leading cause of morbidity and mortality in children younger than 5 years. We report the changes in neonatal outcomes and care practices among very preterm infants in Canada over 14 years within a national, collaborative, continuous quality-improvement program. METHODS: We retrospectively studied infants born at 23–32 weeks’ gestation who were admitted to tertiary neonatal intensive care units that participated in the Evidence-based Practice for Improving Quality program in the Canadian Neonatal Network from 2004 to 2017. The primary outcome was survival without major morbidity during the initial hospital admission. We quantified changes using process-control charts in 6-month intervals to identify special-cause variations, adjusted regression models for yearly changes, and interrupted time series analyses. RESULTS: The final study population included 50 831 infants. As a result of practice changes, survival without major morbidity increased significantly (56.6% [669/1183] to 70.9% [1424/2009]; adjusted odds ratio [OR] 1.08, 95% confidence interval [CI] 1.06–1.10, per year) across all gestational ages. Survival of infants born at 23–25 weeks’ gestation increased (70.8% [97/137] to 74.5% [219/294]; adjusted OR 1.03, 95% CI 1.02–1.05, per year). Changes in care practices included increased use of antenatal steroids (83.6% [904/1081] to 88.1% [1747/1983]), increased rates of normothermia at admission (44.8% [520/1160] to 67.5% [1316/1951]) and reduced use of pulmonary surfactant (52.8% [625/1183] to 42.7% [857/2009]). INTERPRETATION: Network-wide quality-improvement activities that include better implementation of optimal care practices can yield sustained improvement in survival without morbidity in very preterm infants.

Published
2020

19. The International Network for Evaluating Outcomes (iNeo) of neonates: evolution, progress and opportunities

Author

Shah, PS, Lui, K, Reichman, B, Norman, M, Kusuda, S, Lehtonen, L, Adams, M, Vento, M, Darlow, BA, Modi, N, Rusconi, F, Hakansson, S, San Feliciano, L, Helenius, KK, Bassler, D, Hirano, S, Lee, SK, Marshall, P, Schmidt, P, Dhawan, A, Craven, P, De Waal, K, Simmer, K, Gill, A, Pillow, J, Stack, J, Birch, P, Cooke, L, Casalaz, D, Holberton, J, Stewart, A, Downe, L, Stewart, M, Bajuk, B, Berry, A, Hunt, R, Kilburn, C, De Paoli, T, Bolisetty, S, Paradisis, M, Rieger, I, Koorts, P, Kuschel, C, Numa, A, Carlisle, H, Badawi, N, Loughran-Fowlds, A, Koh, G, Davis, J, Luig, M, Andersen, C, Chambers, G, Austin, N, Lynn, A, Darlow, B, Edmonds, L, Mildenhall, L, Buksh, M, Battin, M, Van den Boom, J, Bourchier, D, Richardson, V, Dineen, F, Rajadurai, VS, Fung, G, Harrison, A, Synnes, A, Ting, J, Cieslak, Z, Sherlock, R, Yee, W, Aziz, K, Toye, J, Fajardo, C, Kalapesi, Z, Sankaran, K, Daspal, S, Seshia, M, Alvaro, R, Mukerji, A, Da Silva, O, Nwaesei, C, Lee, K-S, Dunn, M, Lemyre, B, Dow, K, Pelausa, E, Barrington, K, Drolet, C, Piedboeuf, B, Claveau, M, Beltempo, M, Bertelle, V, Masse, E, Canning, R, Mabry, H, Ojah, C, Monterrosa, L, Deshpandey, A, Afifi, J, Kajetanowicz, A, Andersson, S, Tammela, O, Sankilampi, U, Saarela, T, Prazad, P, Noguchi, A, McWan, K, Button, B, Stratton, W, Hamvus, A, Raghaven, A, Derrick, M, Hadley, R, Covert, R, Lablanc, O, Weiss, M, Bell, A, Shareef, M, Silvestri, J, Heymann, E, Zangen, S, Smolkin, T, Mimouni, F, Bader, D, Rothschild, A, Strauss, Z, Felszer, C, Oman, H, Toy-Friedman, SE, Bar-Oz, B, Feldman, M, Saad, N, Flidel-Rimon, O, Weisbrod, M, Lubin, D, Litmanovitz, I, Kngelman, A, Shinwell, E, Klinger, G, Nijim, Y, Bin-Nun, A, Golan, A, Mandel, D, Fleisher-Sheffer, V, Kohelet, D, Bakhrakh, L, Hattori, S, Shirai, M, Ishioka, T, Mori, T, Amiznka, T, Huchimukai, T, Yoshida, H, Sasaki, A, Shimizu, J, Nakamura, T, Maruyama, M, Matsumoto, H, Hosokawa, S, Taki, A, Nakagawa, M, Ko, K, Uozumi, A, Nakata, S, Shimazaki, A, Yoda, T, Numata, O, Imamura, H, Kobayashi, A, Tokuriki, S, Uchida, Y, Arai, T, Ito, M, Ieda, K, Ono, T, Hayashi, M, Maki, K, Yamakawa, M, Kawai, M, Fujii, N, Shiomi, K, Nozaki, K, Wada, H, Kim, T, Tokunaga, Y, Takatera, A, Oshima, T, Sumida, H, Michinomae, Y, Knsumoto, Y, Yoshimoto, S, Morisawa, T, Ohashi, T, Takahashi, Y, Sugimoto, M, Ono, N, Miyagawa, S, Saijo, T, Yamagami, T, Koyano, K, Kobayashi, S, Kanda, T, Sakemi, Y, Aoki, M, Iida, K, Goshi, M, Maruyama, Y, Avila-Alvarez, A, Luis Fernandez-Trisac, J, Couce Pico, ML, Fernandez Seara, MJ, Martinez Gutierrez, A, Vizcaino, C, Salvador Iglesias, M, Sanchez Zaplana, H, Fernandez Colomer, B, Garcia Lopez, JE, Garcia Mozo, R, Gonzalez Martinez, MT, Muro Sebastian, MD, Balart Carbonell, M, Badia Bamnsell, J, Domingo Puiggros, M, Figueras Aloy, J, Botet Mussons, F, Anquela Sanz, I, Ginovart Galiana, G, Coroleu, W, Iriondo, M, Vilella, LC, Porta, R, Demestre, X, Martinez Nadal, S, De Frutos Martinez, C, Lopez Cuesta, MJ, Esquivel Mora, D, Ortiz Tardio, J, Benavente, I, Alonso, A, Aguilera Olmos, R, Garcia Cabezas, MA, Martinez Jimenez, MD, Jaraba Caballero, MF, Ordofiez Diaz, MD, Fagundo, AT, Canals, LM, Garcia-Munoz Rodrigo, F, Urquia Marti, L, Moreno Galdo, MF, Hurtado Suazo, JA, Narbona Lopez, E, Uberos Fernandez, J, Cortajarena Altana, MA, Mora Navarro, D, Teresa Dominguez, M, Ruiz del Prado, MY, Esteban Diez, I, Palau Benavides, MT, Lapena, S, Prada, T, Soler Mir, E, Corredera Sanchez, A, Criado Vega, E, Del Prado, N, Fernandez, C, Cabanillas Vilaplana, L, Cuadrado Perez, I, Lopez Gomez, L, Domingo Comeche, L, Llana Martin, I, Gonzalez Armengod, C, Munoz Labian, C, Santos Munoz, MJ, Blanco Bravo, D, Perez, V, Elorza Fernandez, MD, Diaz Gonzalez, C, Ares Segura, S, Lopez Azorin, M, Belen Jimenez, A, Sanchez-Tamayo, T, Tapia Moreno, E, Gonzalez, M, Sanchez Martinez, JE, Lloreda Garcia, JM, Goni Orayen, C, Vilas Gonzalez, J, Suarez Albo, M, Gonzalez Colmenero, E, Gutierrez Gonzalez, EP, Vacas del Arco, B, Marquez Fernandez, J, Acosta Gordillo, L, Granero Asensio, M, Macias Diaz, C, Albujar, M, Fuster Jorge, P, Romero, S, Rivero Falero, M, Escobar Izquierdo, AB, Estan Capell, J, Izquierdo Macian, MI, Montejo Vicente, MM, Izquierdo Caballero, R, Mercedes Martinez, M, Euba, A, Rodriguez Serna, A, De Heredia Goya, JML, Perez Legorburu, A, Gutierrez Amoros, A, Marugan Isabel, VM, Hernandez Gonzalez, N, Rite Gracia, S, Ventura Faci, MP, Samper Villagrasa, MP, Kofron, J, Brodd, KS, Odlind, A, Alberg, L, Arwehed, S, Hafstrom, O, Kasemo, A, Nederman, K, Ahman, L, Ingemarsson, F, Petersson, H, Thum, P, Albinsson, E, Selander, B, Abrahamsson, T, Heimdahl, I, Sveinsdottir, K, Wejryd, E, Hedlund, A, Soderberg, MK, Hallberg, B, Brune, T, Backstrom, J, Robinson, J, Farooqi, A, Normann, E, Fredriksson, M, Palm, A, Rosenqvist, U, Hagman, C, Ohlin, A, Floral, R, Smedsaas-Lofvenberg, A, Meyer, P, Anderegg, C, Schulzke, S, Nelle, M, Wagner, B, Riedel, T, Kaczala, G, Walde, B, Pfister, RE, Tolsa, J-F, Roth, M, Stocker, M, Laubscher, B, Malzacher, A, Micallef, JP, Hegi, L, Arlettaz, R, Bernet, V, Dani, C, Fiorini, P, Boldrini, A, Tomasini, B, Mittal, A, Kefas, J, Kamalanathan, A, Jayachandran, Yoxall, B, McBride, T, Webb, D, Garr, R, Hassan, A, Ambadkar, P, Dyke, M, McDevitt, K, Rewitzky, G, D'Amore, A, Panasa, N, Settle, P, Maddock, N, Edi-Osagie, N, Zipitis, C, Heal, C, Birch, J, Hasib, A, Soe, A, Kumar, N, Kisat, H, Vasu, V, Lama, M, Gupta, R, Rawlingson, C, Wickham, T, Theron, M, Kendall, G, Gupta, A, Aladangady, N, Ali, I, Alsford, L, Lopez, W, Murthy, V, Sullivan, C, Thomas, M, Bate, T, Godambe, S, Watts, T, Kuna, J, Chang, J, Pai, V, Huddy, C, Yasin, S, Nicholl, R, Pandey, P, Kairamkonda, V, Muogbo, D, Harry, L, Simmons, P, Nycyk, J, Gallagher, A, Pillay, T, Deshpande, S, Mahadevan, Moore, A, Clark, S, Garbash, M, Lal, M, Abu-Harb, M, Allwood, A, Selter, M, Munyard, P, Bartle, D, Paul, S, Whincup, G, Mallik, A, Amess, P, Godden, C, Reynolds, P, Misra, I, De Halpert, P, Salgia, S, Sanghavi, R, Wigfield, R, Deketelaere, A, Khashu, M, Hall, M, Groves, C, Brown, N, Brennan, N, Vamvakiti, K, McIntyre, J, Pirie, S, Jones, S, Mannix, P, Cairns, P, Eaton, M, Schwarz, K, Gibson, D, Miall, L, Krishnamurthy, University of Zurich, Shah, Prakesh S, Canadian Institutes of Health Research (CIHR), and Neonid NPO

Subjects
medicine.medical_specialty, NEW-ZEALAND, Population, 610 Medicine & health, RETINOPATHY, Review Article, Audit, Pediatrics, outcomes research, MORBIDITY, Nursing, neonatal intensive care, Health care, medicine, LOW-BIRTH-WEIGHT, 2735 Pediatrics, Perinatology and Child Health, education, education.field_of_study, Science & Technology, EXTREMELY PRETERM INFANTS, business.industry, MORTALITY, Public health, Health services research, Preterm infants, Capacity building, BRONCHOPULMONARY DYSPLASIA, Benchmarking, 10027 Clinic for Neonatology, INTENSIVE-CARE UNITS, TRENDS, CANADA, Pediatrics, Perinatology and Child Health, Outcomes research, business, Life Sciences & Biomedicine
Abstract

Neonates born very preterm (before 32 weeks’ gestational age), are a significant public health concern because of their high-risk of mortality and life-long disability. In addition, caring for very preterm neonates can be expensive, both during their initial hospitalization and their long-term cost of permanent impairments. To address these issues, national and regional neonatal networks around the world collect and analyse data from their constituents to identify trends in outcomes, and conduct benchmarking, audit and research. Improving neonatal outcomes and reducing health care costs is a global problem that can be addressed using collaborative approaches to assess practice variation between countries, conduct research and implement evidence-based practices. The International Network for Evaluating Outcomes (iNeo) of neonates was established in 2013 with the goal of improving outcomes for very preterm neonates through international collaboration and comparisons. To date, 10 national or regional population-based neonatal networks/datasets participate in iNeo collaboration. The initiative now includes data on >200,000 very preterm neonates and has conducted important epidemiological studies evaluating outcomes, variations and trends. The collaboration has also surveyed >320 neonatal units worldwide to learn about variations in practices, healthcare service delivery, and physical, environmental and manpower related factors and support services for parents. The iNeo collaboration serves as a strong international platform for Neonatal-Perinatal health services research that facilitates international data sharing, capacity building, and global efforts to improve very preterm neonate care.

Published
2019

20. The International Network for Evaluating Outcomes (iNeo) of neonates: evolution, progress and opportunities

Author

Shah P, Lui K, Reichman B, Norman M, Kusuda S, Lehtonen L, Adams M, Vento M, Darlow B, Modi N, Rusconi F, Hakansson S, San Feliciano L, Helenius K, Bassler D, Hirano S, Lee S, Marshall P, Schmidt P, Dhawan A, Craven P, de Waal K, Simmer K, Gill A, Pillow J, Stack J, Birch P, Cooke L, Casalaz D, Holberton J, Stewart A, Downe L, Stewart M, Bajuk B, Berry A, Hunt R, Kilburn C, De Paoli T, Bolisetty S, Paradisis M, Rieger I, Koorts P, Kuschel C, Numa A, Carlisle H, Badawi N, Loughran-Fowlds A, Koh G, Davis J, Luig M, Andersen C, Chambers G, Austin N, Lynn A, Edmonds L, Mildenhall L, Buksh M, Battin M, van den Boom J, Bourchier D, Richardson V, Dineen F, Rajadurai V, Fung G, Harrison A, Synnes A, Ting J, Cieslak Z, Sherlock R, Yee W, Aziz K, Toye J, Fajardo C, Kalapesi Z, Sankaran K, Daspal S, Seshia M, Alvaro R, Mukerji A, Da Silva O, Nwaesei C, Lee K, Dunn M, Lemyre B, Dow K, Pelausa E, Barrington K, Drolet C, Piedboeuf B, Claveau M, Beltempo M, Bertelle V, Masse E, Canning R, Mabry H, Ojah C, Monterrosa L, Deshpandey A, Afifi J, Kajetanowicz A, Andersson S, Tammela O, Sankilampi U, Saarela T, Prazad P, Noguchi A, McWan K, Button B, Stratton W, Hamvus A, Raghaven A, Derrick M, Hadley R, Covert R, Lablanc O, Weiss M, Bell A, Shareef M, Silvestri J, Heymann E, Zangen S, Smolkin T, Mimouni F, Bader D, Rothschild A, Strauss Z, Felszer C, Oman H, Toy-Friedman S, Bar-Oz B, Feldman M, Saad N, Flidel-Rimon O, Weisbrod M, Lubin D, Litmanovitz I, Kngelman A, Shinwell E, Klinger G, Nijim Y, Bin-Nun A, Golan A, Mandel D, Fleisher-Sheffer V, Kohelet D, Bakhrakh L, Hattori S, Shirai M, Ishioka T, Mori T, Amiznka T, Huchimukai T, Yoshida H, Sasaki A, Shimizu J, Nakamura T, Maruyama M, Matsumoto H, Hosokawa S, Taki A, Nakagawa M, Ko K, Uozumi A, Nakata S, Shimazaki A, Yoda T, Numata O, Imamura H, Kobayashi A, Tokuriki S, Uchida Y, Arai T, Ito M, Ieda K, Ono T, Hayashi M, Maki K, Yamakawa M, Kawai M, Fujii N, Shiomi K, Nozaki K, Wada H, Kim T, Tokunaga Y, Takatera A, Oshima T, Sumida H, Michinomae Y, Knsumoto Y, Yoshimoto S, Morisawa T, Ohashi T, Takahashi Y, Sugimoto M, Ono N, Miyagawa S, Saijo T, Yamagami T, Koyano K, Kobayashi S, Kanda T, Sakemi Y, Aoki M, Iida K, Goshi M, Maruyama Y, Avila-Alvarez A, Fernandez-Trisac J, Pico M, Seara M, Gutierrez A, Vizcaino C, Iglesias M, Zaplana H, Colomer B, Lopez J, Mozo R, Martinez M, Sebastian M, Carbonell M, Bamnsell J, Puiggros M, Aloy J, Mussons F, Sanz I, Galiana G, Coroleu W, Iriondo M, Vilella L, Porta R, Demestre X, Nadal S, Martinez C, Cuesta M, Mora D, Tardio J, Benavente I, Alonso A, Olmos R, Cabezas M, Jimenez M, Caballero M, Diaz M, Fagundo A, Canals L, Rodrigo F, Marti L, Galdo M, Suazo J, Lopez E, Fernandez J, Altana M, Navarro D, Dominguez M, del Prado M, Diez I, Benavides M, Lapena S, Prada T, Mir E, Sanchez A, Vega E, del Prado N, Fernandez C, Vilaplana L, Perez I, Gomez L, Comeche L, Martin I, Armengod C, Labian C, Munoz M, Bravo D, Perez V, Fernandez M, Gonzalez C, Segura S, Azorin M, Jimenez A, Sanchez-Tamayo T, Moreno E, Gonzalez M, Martinez J, Garcia J, Orayen C, Gonzalez J, Albo M, Colmenero E, Gonzalez E, del Arco B, Gordillo L, Asensio M, Diaz C, Albujar M, Jorge P, Romero S, Falero M, Izquierdo A, Capell J, Macian M, Vicente M, Caballero R, Euba A, Serna A, Goya J, Legorburu A, Amoros A, Isabel V, Gonzalez N, Gracia S, Faci M, Villagrasa M, Kofron J, Brodd K, Odlind A, Alberg L, Arwehed S, Hafstrom O, Kasemo A, Nederman K, Ahman L, Ingemarsson F, Petersson H, Thum P, Albinsson E, Selander B, Abrahamsson T, Heimdahl I, Sveinsdottir K, Wejryd E, Hedlund A, Soderberg M, Hallberg B, Brune T, Backstrom J, Robinson J, Farooqi A, Normann E, Fredriksson M, Palm A, Rosenqvist U, Hagman C, Ohlin A, Floral R, Smedsaas-Lofvenberg A, Meyer P, Anderegg C, Schulzke S, Nelle M, Wagner B, Riedel T, Kaczala G, Walde B, Pfister R, Tolsa J, Roth M, Stocker M, Laubscher B, Malzacher A, Micallef J, Hegi L, Arlettaz R, Bernet V, Dani C, Fiorini P, Boldrini A, Tomasini B, Mittal A, Kefas J, Kamalanathan A, Jayachandran, Yoxall B, McBride T, Webb D, Garr R, Hassan A, Ambadkar P, Dyke M, McDevitt K, Rewitzky G, D'Amore A, Panasa N, Settle P, Maddock N, Edi-Osagie N, Zipitis C, Heal C, Birch J, Hasib A, Soe A, Kumar N, Kisat H, Vasu V, Lama M, Gupta R, Rawlingson C, Wickham T, Theron M, Kendall G, Gupta A, Aladangady N, Ali I, Alsford L, Lopez W, Murthy V, Sullivan C, Thomas M, Bate T, Godambe S, Watts T, Kuna J, Chang J, Pai V, Huddy C, Yasin S, Nicholl R, Pandey P, Kairamkonda V, Muogbo D, Harry L, Simmons P, Nycyk J, Gallagher A, Pillay T, Deshpande S, Mahadevan, Moore A, Clark S, Garbash M, Lal M, Abu-Harb M, Allwood A, Selter M, Munyard P, Bartle D, Paul S, Whincup G, Mallik A, Amess P, Godden C, Reynolds P, Misra I, De Halpert P, Salgia S, Sanghavi R, Wigfield R, Deketelaere A, Khashu M, Hall M, Groves C, Brown N, Brennan N, Vamvakiti K, McIntyre J, Pirie S, Jones S, Mannix P, Cairns P, Eaton M, Schwarz K, Gibson D, Miall L, Krishnamurthy, and Int Network Evaluating Outcomes iN

Subjects
outcomes research, neonatal intensive care, Preterm infants
Abstract

Neonates born very preterm (before 32 weeks' gestational age), are a significant public health concern because of their high-risk of mortality and life-long disability. In addition, caring for very preterm neonates can be expensive, both during their initial hospitalization and their long-term cost of permanent impairments. To address these issues, national and regional neonatal networks around the world collect and analyse data from their constituents to identify trends in outcomes, and conduct benchmarking, audit and research. Improving neonatal outcomes and reducing health care costs is a global problem that can be addressed using collaborative approaches to assess practice variation between countries, conduct research and implement evidence-based practices. The International Network for Evaluating Outcomes (iNeo) of neonates was established in 2013 with the goal of improving outcomes for very preterm neonates through international collaboration and comparisons. To date, 10 national or regional population-based neonatal networks/datasets participate in iNeo collaboration. The initiative now includes data on >200,000 very preterm neonates and has conducted important epidemiological studies evaluating outcomes, variations and trends. The collaboration has also surveyed >320 neonatal units worldwide to learn about variations in practices, healthcare service delivery, and physical, environmental and manpower related factors and support services for parents. The iNeo collaboration serves as a strong international platform for Neonatal-Perinatal health services research that facilitates international data sharing, capacity building, and global efforts to improve very preterm neonate care.

Published
2019

21. Trends in Outcomes for Neonates Born Very Preterm and Very Low Birth Weight in 11 High-Income Countries

Author

Lui K, Lee S, Kusuda S, Adams M, Vento M, Reichman B, Darlow B, Lehtonen L, Modi N, Norman M, Hakansson S, Bassler D, Rusconi F, Lodha A, Yang J, Shah P, Marshall P, Schmidt P, Dhawan A, Craven P, de Waal K, Simmer K, Gill A, Pillow J, Stack J, Birch P, Cooke L, Casalaz D, Holberton J, Stewart A, Downe L, Stewart M, Bajuk B, Berry A, Hunt R, Kilburn C, De Paoli T, Bolisetty S, Paradisis M, Rieger I, Koorts P, Kuschel C, Doyle L, Numa A, Carlisle H, Badawi N, Loughran-Fowlds A, Koh G, Davis J, Luig M, Andersen C, Chambers G, Austin N, Lynn A, Edmonds L, Mildenhall L, Buksh M, Battin M, van den Boom J, Bourchier D, Richardson V, Dineen F, Rajadurai V, Lam S, Fung G, Harrison A, Synnes A, Cieslak Z, Sherlock R, Yee W, Aziz K, Fajardo C, Kalapesi Z, Sankaran K, Daspal S, Seshia M, Alvaro R, Mukerji A, Da Silva O, Nwaesei C, Lee K, Dunn M, Lemyre B, Dow K, Pelausa E, Barrington K, Drolet C, Piedboeuf B, Claveau M, Beltempo M, Bertelle V, Masse E, Canning R, Makary H, Ojah C, Monterrosa L, Deshpandey A, Afifi J, Kajetanowicz A, Andersson S, Tammela O, Sankilampi U, Saarela T, Prazad P, Noguchi A, McWan K, Button B, Stratton W, Hamvus A, Raghaven A, Derrick M, Hadley R, Covert R, Lablanc O, Weiss M, Bell A, Shareef M, Silvestri J, Heymann E, Zangen S, Smolkin T, Mimouni F, Bader D, Rothschild A, Strauss Z, Felszer C, Omari H, Tov-Friedman S, Bar-Oz B, Feldman M, Saad N, Flidel-Rimon O, Weisbrod M, Lubin D, Litmanovitz I, Kugelman A, Shinwell E, Klinger G, Nijim Y, Bin-Nun A, Golan A, Mandel D, Fleisher-Sheffer V, Kohelet D, Bakhrakh L, Hattori S, Shirai M, Ishioka T, Mori T, Amizuka T, Huchimukai T, Yoshida H, Sasaki A, Shimizu J, Nakamura T, Maruyama M, Matsumoto H, Hosokawa S, Taki A, Nakagawa M, Ko K, Uozumi A, Nakata S, Shimazaki A, Yoda T, Numata O, Imamura H, Kobayashi A, Tokuriki S, Uchida Y, Arai T, Ito M, Ieda K, Ono T, Hayashi M, Maki K, Yamakawa M, Kawai M, Fujii N, Shiomi K, Nozaki K, Wada H, Kim T, Tokunaga Y, Takatera A, Oshima T, Sumida H, Michinomae Y, Kusumoto Y, Yoshimoto S, Morisawa T, Ohashi T, Takahashi Y, Sugimoto M, Ono N, Miyagawa S, Saijo T, Yamagami T, Koyano K, Kobayashi S, Kanda T, Sakemi Y, Aoki M, Iida K, Goshi M, Maruyama Y, Avila-Alvarez A, Ting J, Toye J, Fernandez-Trisac J, Pico M, Seara M, Gutierrez A, Vizcaino C, Iglesias M, Zaplana H, Colomer B, Lopez J, Mozo R, Martinez M, Sebastian M, Carbonell M, Barnusell J, Puiggros M, Aloy J, Mussons F, Sanz I, Galiana G, Coroleu W, Iriondo M, Vilella L, Porta R, Demestre X, Nadal S, Martinez C, Cuesta M, Mora D, Tardio J, Benavente I, Alonso A, Olmos R, Cabezas M, Jimenez M, Caballero P, Diaz M, Fagundo A, Canals L, Rodrigo F, Marti L, Galdo M, Suazo J, Lopez E, Fernandez J, Altuna M, Muga O, Navarro D, Dominguez M, del Prado M, Diez I, Benavides M, Lapena S, Prada T, Mir E, Sanchez A, Vega E, del Prado N, Fernandez C, Vilaplana L, Perez I, Gomez L, Comeche L, Martin I, Armengod C, Labian C, Munoz M, Bravo D, Perez V, Fernandez M, Gonzalez C, Segura S, Azorin M, Jimenez A, Sanchez-Tamayo T, Moreno E, Gonzalez M, Martinez J, Garcia J, Orayen C, Gonzalez J, Albo M, Colmenero E, Gonzalez E, del Arco B, Gordillo L, Asensio M, Diaz C, Albujar R, Jorge P, Romero S, Falero M, Izquierdo A, Capell J, Vicente M, Caballero R, Euba A, Serna A, Goya J, Legorburu A, Amoros A, Isabel V, Gonzalez N, Gracia S, Faci P, Villagrasa M, Macian M, Kofron J, Brodd K, Odlind A, Alberg L, Arwehed S, Hafstrom O, Kasemo A, Nederman K, Ahman L, Ingemarsson F, Petersson H, Thurn P, Albinsson E, Selander B, Abrahamsson T, Heimdahl I, Sveinsdottir K, Wejryd E, Hedlund A, Soderberg M, Hallberg B, Brune T, Backstrom J, Robinson J, Farooqi A, Normann E, Fredriksson M, Palm A, Rosenqvist U, Walde B, Hagman C, Ohlin A, Florell R, Smedsaas-Lofvenberg A, Meyer P, Anderegg C, Schulzke S, Nelle M, Wagner B, Riedel T, Kaczala G, Pfister R, Tolsa J, Roth M, Stocker M, Laubscher B, Malzacher A, Micallef J, Hegi L, Arlettaz R, Bernet V, Fiorini P, Boldrini A, Tomasini B, Kefas J, Kamalanathan A, Jayachandran, Yoxall B, McBride T, Webb D, Garr R, Hassan A, Ambadkar P, Dyke M, McDevitt K, Rewitzky G, D'Amore A, Panasa N, Settle P, Maddock N, Edi-Osagie N, Zipitis C, Heal C, Birch J, Hasib A, Soe A, Kumar N, Kisat H, Vasu V, Lama M, Gupta R, Rawlingson C, Wickham T, Theron M, Kendall G, Gupta A, Aladangady N, Ali I, Alsford L, Lopez W, Murthy V, Sullivan C, Thomas M, Bate T, Godambe S, Watts T, Kuna J, Chang J, Pai V, Huddy C, Yasin S, Nicholl R, Pandey P, Cusack J, Kairamkonda V, Muogbo D, Harry L, Simmons P, Nycyk J, Gallagher A, Pillay T, Deshpande S, Mahadevan, Moore A, Clark S, Garbash M, Lal M, Abu-Harb M, Dani C, Mittal A, Allwood A, Selter M, Munyard P, Bartle D, Paul S, Whincup G, Mallik A, Amess P, Godden C, Reynolds P, Misra I, De Halpert P, Salgia S, Sanghavi R, Wigfield R, Deketelaere A, Khashu M, Hall M, Groves C, Brown N, Brennan N, Vamvakiti K, McIntyre J, Pirie S, Jones S, Mannix P, Cairns P, Eaton M, Schwarz K, Gibson D, Miall L, Krishnamurthy, and Int Network Evaluation Outcomes iN

Abstract

Objective To evaluate outcome trends of neonates born very preterm in 11 high-income countries participating in the International Network for Evaluating Outcomes of neonates. Study design In a retrospective cohort study, we included 154 233 neonates admitted to 529 neonatal units between January 1, 2007, and December 31, 2015, at 24(0/7) to 31(6/7) weeks of gestational age and birth weight

Published
2019

22. Retrospective analysis of oral cavity squamous cell carcinoma treated with surgery and adjuvent radiotherapy

Author

Mohit Sharma, Abhinav Deshpandey, Mahesh Patel, and Nayan Gupta

Subjects
Oral Cavity SCC, medicine.medical_specialty, business.industry, medicine.medical_treatment, Cancer, Local failure, medicine.disease, Lymphovascular, Surgery, Causes of cancer, Radiation therapy, medicine, Retrospective analysis, Oral Cavity Squamous Cell Carcinoma, business
Abstract

Background: Oral cavity cancer is one of the leading causes of cancer related deaths in developing countries. Most of the failures occur due to locoregional recurrence. The present study was conducted to find out the pattern of recurrences and factors responsible for that in oral cavity squamous cell carcinoma (SCC). Methods: The study was conducted at Gujarat cancer and research institute Ahmedabad, India. Total 260 patients were evaluated in study from year January 2013 to December 2013 retrospectively. Two year follow up was studied to find out the pattern of failure in terms of local, regional (nodal) and systemic. Results: Oral cavity SCC has high chances of local failure when removed inadequately during surgery. Perineural spread, lymphovascular involvement and perinodal spread are important prognostic factors. Conclusions: Most patients of oral cavity cancer present in advanced stages. Close margins and perineural involvement are responsible for local recurrences while perinodal spread and lymphovascular involvement contributes to nodal recurrences. Tobacco consumption is important responsible factor.

Published
2016
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23. International, multicentre, observational study of fluid bolus therapy in neonates

Author

Keir, AK, Karam, O, Hodyl, N, Stark, MJ, Liley, HG, Shah, PS, Stanworth, SJ, Morris, S, Carmo, KB, De Waal, K, Stubbs, M, Liley, H, Pearson, A, Campbell, H, Hunt, RW, Perkins, E, Ali, SKM, Bowen, J, Jacobs, C, Paradisis, M, Osborn, D, Greenhalgh, M, Kuschel, C, Stark, M, Keir, A, Ting, J, Barrington, K, Lapointe, A, Dow, K, Coo, H, Mukerji, A, Mohamed, A, Stavel, M, Deshpandey, A, Tucker, N, Ng, E, Diamond, C, Bourgoin, P, Bindl, L, Maria, M, De Luca, D, Dell'Orto, V, Ghirardello, S, More, K, Edmonds, L, Weaver, L, Deschmann, E, Norman, M, Thomas, O, Karlsson, J, De Luca, R, Rogdo, B, Moinho, R, Dinis, A, Wilkinson, D, Paria, A, Sola-Visner, M, Young, V, Josephson, CD, Skvarich, J, Saxonhouse, M, Poliquin, R, Courtney, S, Janssen, D, Harm, SK, Bartlett, A, Mayock, D, Lee, G, Keir, AK, Karam, O, Hodyl, N, Stark, MJ, Liley, HG, Shah, PS, Stanworth, SJ, Morris, S, Carmo, KB, De Waal, K, Stubbs, M, Liley, H, Pearson, A, Campbell, H, Hunt, RW, Perkins, E, Ali, SKM, Bowen, J, Jacobs, C, Paradisis, M, Osborn, D, Greenhalgh, M, Kuschel, C, Stark, M, Keir, A, Ting, J, Barrington, K, Lapointe, A, Dow, K, Coo, H, Mukerji, A, Mohamed, A, Stavel, M, Deshpandey, A, Tucker, N, Ng, E, Diamond, C, Bourgoin, P, Bindl, L, Maria, M, De Luca, D, Dell'Orto, V, Ghirardello, S, More, K, Edmonds, L, Weaver, L, Deschmann, E, Norman, M, Thomas, O, Karlsson, J, De Luca, R, Rogdo, B, Moinho, R, Dinis, A, Wilkinson, D, Paria, A, Sola-Visner, M, Young, V, Josephson, CD, Skvarich, J, Saxonhouse, M, Poliquin, R, Courtney, S, Janssen, D, Harm, SK, Bartlett, A, Mayock, D, and Lee, G

Abstract

AIM: To assess the prevalence, types and indications for fluid bolus therapy in neonates with haemodynamic compromise. METHODS: This was a pragmatic, international, multicentre observational study in neonatal units across Australasia, Europe and North America with a predefined study period of 10-15 study days per participating neonatal unit between December 2015 and March 2017. Infants ≤28 days of age who received a fluid bolus for the management of haemodynamic compromise (≥10 mL/kg given at ≤6 h) were included. RESULTS: A total of 163 neonates received a bolus over 8479 eligible patient days in 41 neonatal units. Prevalence of fluid bolus therapy varied between centres from 0 to 28.6% of admitted neonates per day, with a pooled prevalence rate of 1.5% (95% confidence interval 1.1-1.9%). The most common fluid used was 0.9% sodium chloride (129/163; 79%), and the volume of fluid administered was most commonly 10 mL/kg (115/163; 71%) over a median of 30 min (interquartile range 20-60). The most frequent indications were hypotension (n = 56; 34%), poor perfusion (n = 20; 12%) and metabolic acidosis (n = 20; 12%). Minimal or no clinical improvement was reported by clinicians in 66 of 163 cases (40%). CONCLUSIONS: Wide international variations in types, indications and effects of fluid bolus administration in haemodynamically compromised neonates suggest uncertainty in the risk-benefit profile. This is likely to reflect the lack of robust evidence to support the efficacy of different fluid types, doses and appropriate indications. Together, these highlight a need for further clinically relevant studies.

Published
2019

25. Association Between Antibiotic Use and Neonatal Mortality and Morbidities in Very Low-Birth-Weight Infants Without Culture-Proven Sepsis or Necrotizing Enterocolitis

Author

Eugene W. Yoon, Shoo K. Lee, Akhil Deshpandey, Simon Dobson, Anne Synnes, Joseph Ting, Kimberly Dow, Ashley Roberts, Kyong-Soon Lee, and Prakesh S. Shah

Subjects
Male, Pediatrics, medicine.medical_specialty, Canada, Critical Care, 03 medical and health sciences, 0302 clinical medicine, Enterocolitis, Necrotizing, 030225 pediatrics, Intensive Care Units, Neonatal, Sepsis, Infant Mortality, medicine, Humans, Infant, Very Low Birth Weight, 030212 general & internal medicine, Retrospective Studies, Enterocolitis, Neonatal sepsis, business.industry, Infant, Newborn, Gestational age, Infant, Retinopathy of prematurity, Retrospective cohort study, Odds ratio, Length of Stay, medicine.disease, Anti-Bacterial Agents, Low birth weight, Perinatal Care, Pediatrics, Perinatology and Child Health, Necrotizing enterocolitis, Female, medicine.symptom, Morbidity, business
Abstract

Excessive antibiotic use has been associated with altered bacterial colonization and may result in antibiotic resistance, fungemia, necrotizing enterocolitis (NEC), and mortality. Exploring the association between antibiotic exposure and neonatal outcomes other than infection-related morbidities may provide insight on the importance of rational antibiotic use, especially in the setting of culture-negative neonatal sepsis.To evaluate the trend of antibiotic use among all hospitalized very low-birth-weight (VLBW) infants across Canada and the association between antibiotic use rates (AURs) and mortality and morbidity among neonates without culture-proven sepsis or NEC.A retrospective cohort study was conducted among VLBW infants (1500 g) admitted to level III neonatal intensive care units between January 1, 2010, and December 31, 2014, using data obtained from the Canadian Neonatal Network database.Duration of antibiotic use during the hospitalization period.The AUR was defined as the number of days an infant was exposed to 1 or more antimicrobial agents divided by the total length of hospital stay. The composite primary outcome was defined as mortality or major morbidity, including any of the following: persistent periventricular echogenicity or echolucency on neuroimaging, chronic lung disease, and stage 3 or higher retinopathy of prematurity. Multivariable regression analysis was used to calculate adjusted odds ratios (aORs) and 95% CIs for the association between AURs and outcomes.Among 13 738 eligible VLBW infants, 11 669 (84.9%) (mean [SD] gestational age, 27.7 [2.5] weeks; 47.4% female) received antibiotics during their hospital course and were included in the study. The annual AUR decreased from 0.29 in 2010 to 0.25 in 2014 (slope for the best-fit line, -0.011; 95% CI, -0.016 to -0.006; P .01), which occurred in parallel with a reduction in the rate of late-onset sepsis from 19.0% in 2010 to 13.8% in 2014 during the same period. Of the 11 669 infants who were treated with antibiotics of varying duration during their hospital stay, 2845 were diagnosed as having sepsis-related complications. Among the remaining 8824 infants without early-onset sepsis, late-onset sepsis, or NEC, a 10% increase in the AUR was associated with an increased odds of the primary composite outcome (aOR, 1.18; 95% CI, 1.13-1.23), mortality (aOR, 2.04; 95% CI, 1.87-2.21), and stage 3 or higher retinopathy of prematurity (aOR, 1.18; 95% CI, 1.06-1.32).Antibiotic use in VLBW infants decreased between 2010 and 2014 in Canada. However, among infants without culture-proven sepsis or without NEC, higher AURs were associated with adverse neonatal outcomes.

Published
2016

26. Effect of sandblasting on fracture load of titanium ceramic crowns

Author

Pawan Kulkarni, Sharanbassapa Nagral, Sumit Deshpandey, Kishor Singh Bhandari, and Arvind I Moldi

Subjects
Universal testing machine, sandblasting, Materials science, Bonding, Bond strength, fracture load, Significant difference, Fracture load, chemistry.chemical_element, lcsh:RK1-715, Fracture toughness, Flexural strength, chemistry, lcsh:Dentistry, visual_art, visual_art.visual_art_medium, Original Article, Ceramic, titanium, Oral Surgery, Composite material, General Dentistry, Titanium
Abstract

Purpose of the Study: It is difficult to achieve a reliable bond between the titanium and veneering porcelain. The aim of this study was to evaluate the bond strength between titanium ceramic crowns. Materials and Methods: The surfaces of titanium copings were divided in two groups. Group A sandblasted with 250 um (n = 10) and Group B without sandblasting (n = 10). Low-fusing porcelain was bonded over copings. A universal testing machine was used to determine the fracture load (N) of the crowns. All data were compared using Student′s t-test. Results: There was a significant difference in fracture toughness between two groups (P = 0.05). The mean value of fracture strength for Group A was 721.66 N and for Group B was 396.39 N. Conclusions: Sandblasting improves the bond strength between titanium, and ceramic, mechanical bonding plays a crucial role in the bonding between titanium and ceramic.

Published
2016

27. Cognitive functions in first degree normative relative of patients with schozophrenia

Author

Falguni Ankur Chaudhari, Parag S. Shah, and Ujjwala Deshpandey

Subjects
business.industry, Normative, Medicine, Cognition, business, Degree (music), Cognitive psychology
Abstract

Background: Schizophrenia is severe disorders and imposes a considerable burden on patients, their families and society. Schizophrenia tends to run in family, like most mental disorder shows complex inheritance. Therefore, it is important to increase our knowledge about the disorder. Cognitive dysfunction is one of the core features of Schizophrenia. This study aims to compare the cognitive function of first degree unaffected relative of patient of schizophrenia and a group of healthy control.Methods: The study include 48 first degree normative relative of patient with Schizophrenia and 48 controls. Compared for age, sex, education level. Cognitive functions of each case and control were assessed using TMT (Trail making Test), Paced auditory serial addition Test (PASAT) and Wisconsin card sorting test (WCST-64).Results: First degree relative performed significantly poorly as compared to controls on Wisconsin card sorting Test-64 (WCST-64). No significant difference was observed in tests performances between first degree relative of Schizophrenia and control group for TMT (trail making test) and Paced auditory serial addition Test (PASAT).Conclusions: The study shows possibility of cognitive impairment in first degree normative relative of Schizophrenia with regards to parameters like poor performance in shifting cognitive sets and poor understanding of test. Nevertheless, it is not clear weather this finding is an enduring trait mark or finding that fluctuates with sample size, nature of case and control.

Published
2018
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30. Ultrafine aluminium nitride powder produced by plasma-assisted chemical vapour deposition of trimethylaluminium

Author

Chin Hsiung Ho, H.J. Doerr, Rointan F. Bunshah, Kwang Ho Kim, and C.V. Deshpandey

Subjects
Materials science, Aluminium nitride, Mechanical Engineering, Aluminium carbide, food and beverages, Mineralogy, Chemical vapor deposition, Dissociation (chemistry), law.invention, chemistry.chemical_compound, Crystallinity, chemistry, Chemical engineering, Mechanics of Materials, law, General Materials Science, Particle size, Trimethylaluminium, Susceptor
Abstract

Plasma-assisted chemical vapour deposition of trimethylaluminium (TMAI) with ammonia (NH3) as reactive gas, was used to prepare aluminium nitride (AIN) ultrafine powder. The effect of r.f. current, susceptor temperature and TMAI concentration on particle formation was studied. High r.f. current activated the gas-phase reaction sufficiently to obtain considerable powder formation. It was observed that increasing susceptor temperature led to an increase of powder formation rate and improved the crystallinity of as-synthesized AIN powder as well. Increasing TMAI concentration, on the other hand, led to an increase of powder formation rate of AIN, while much higher TMAI concentration induced the formation of an aluminium carbide (Al4C3) phase due to dissociation of the methyl radicals instead of the Al-C bond.

Published
1992
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31. High Oxygen Storage Capacity and High Rates of CO Oxidation and NO Reduction Catalytic Properties of Ce1-xSnxO2 and Ce0.78Sn0.2Pd0.02O2-delta

Author

M. S. Hegde, Tinku Baidya, Paraag A. Deshpandey, Giridhar Madras, and Asha Gupta

Subjects
Materials Research Centre, Inorganic chemistry, Ionic bonding, chemistry.chemical_element, Solid State & Structural Chemistry Unit, Chemical Engineering, Redox, Oxalate, Surfaces, Coatings and Films, Electronic, Optical and Magnetic Materials, Catalysis, chemistry.chemical_compound, General Energy, chemistry, X-ray photoelectron spectroscopy, Physical and Theoretical Chemistry, Selectivity, Tin, Solid solution
Abstract

Ce1-xSnxO2 (x = 0.1-0.5) solid solution and its Pd substituted analogue have been prepared by a single step solution combustion method using tin oxalate precursor. The compounds were characterized by X-ray diffraction (XRD), X-ray photoelectron spectroscopy (XPS), transmission electron microscopy (TEM), and H-2/temperature programmed redution (TPR) studies. The cubic fluorite structure remained intact up to 50% of Sri substitution in CeO2, and the compounds were stable up to 700 C. Oxygen storage capacity of Ce1-xSnxO2 was found to be much higher than that of Ce1-xZrxO2 due to accessible Ce4+/Ce3+ and Sn4+/Sn2+ redox couples at temperatures between 200 and 400 C. Pd 21 ions in Ce0.78Sn0.2Pd0.02O2-delta are highly ionic, and the lattice oxygen of this catalyst is highly labile, leading to low temperature CO to CO2 conversion. The rate of CO oxidation was 2 mu mol g(-1) s(-1) at 50 degrees C. NO reduction by CO with 70% N-2 selectivity was observed at similar to 200 degrees C and 100% N-2 selectivity below 260 degrees C with 1000-5000 ppm NO. Thus, Pd2+ ion substituted Ce1-xSnxO2 is a superior catalyst compared to Pd2+ ions in CeO2, Ce1-xZrxO2, and Ce1-xTixO2 for low temperature exhaust applications due to the involvement of the Sn2+/Sn4+ redox couple along with Pd2+/Pd-0 and Ce4+/Ce3+ couples.

Published
2009

32. Quasi-optical millimeter-wave band-pass filters using high-T/sub c/ superconductors

Author

S. Praskash, M. Matloubian, Harold R. Fetterman, C.V. Deshpandey, T. W. Kim, Dawei Zhang, K. Daly, Rointan F. Bunshah, and K. Chou

Subjects
Radiation, High-temperature superconductivity, Materials science, business.industry, Electrical engineering, Condensed Matter Physics, law.invention, Band-pass filter, law, Q factor, Extremely high frequency, Optoelectronics, Electrical and Electronic Engineering, Center frequency, business, Optical filter, Passband, Microwave
Abstract

Quasioptical millimeter-wave band-pass filters using YBa/sub 2/Cu/sub 3/O/sub 7/ high-T/sub c/ superconducting films were fabricated on MgO and LaAlO/sub 3/ substrates. Transmitted power through the filter was investigated in the 75 GHz to 110 GHz frequency range at temperatures ranging from 15 to 300 K. At 15 K the measured center frequency and the bandwidth of the superconducting filter were 92 GHz and 0.85 GHz, respectively. Measurements of YBa/sub 2/Cu/sub 3/O/sub 7/ filters were compared with similar filters fabricated using gold. At 15 K and 92 GHz, an improvement of 75% in the quality factor of the superconducting filter was obtained compared with a similar gold filter. >

Published
1991
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37. Prosthetic Rehabilitation of Maxillectomy Defect with a Definitive Hollow Bulb Obturator

Author

Prakash Pushkar Somani; PACIFIC DENTAL COLLLEGE & HOSPITALS AIRPORT ROAD, DEBARI, UDAIPUR - 313024 (RAJASTHAN) INDIA, R. Srinivasa Rao, Abhinav Agrawal, Subbarayudu G., Sumit Deshpandey, D.R.V. Kumar, Prakash Pushkar Somani; PACIFIC DENTAL COLLLEGE & HOSPITALS AIRPORT ROAD, DEBARI, UDAIPUR - 313024 (RAJASTHAN) INDIA, R. Srinivasa Rao, Abhinav Agrawal, Subbarayudu G., Sumit Deshpandey, and D.R.V. Kumar

Abstract

The maxillofacial patient can experience the anatomic complexity of the midface and nearly endless potential for surgical or traumatic defects size, shape and location characteristics of and treatment consideration for maxillary defects present an unlimited variety of possible configurations. Defects are frequently associated with problems that result from lack of retention and stability. This case report is of the rehabilitation of a compromised Armany class I maxillectomy defect with a definitive hollow bulb obturator.

Published
2011

38. Retroperitoneal fetus-in-fetu: another supportive evidence for twinning theory

Author

Gowhar N Mufti, Vidyanand Deshpandey, Satish Kumar Aggarwal, Simmi K. Ratan, Anjan Kumar Dhua, and Nita Khurana

Subjects
business.industry, medicine.medical_treatment, Anatomy, Histopathological examination, medicine.disease, Dizygotic twins, medicine.anatomical_structure, Laparotomy, Fetus in fetu, Abdominal fullness, medicine, Upper limb, business, Fetiform Mass, Calcification
Abstract

An 8-year-old boy with large abdominal lump causing upper abdominal fullness is presented. Clinically it mimicked a trichobezoar because of the restricted side-to-side mobility of the lump. The lump, however, had calcification and radiological features of fetus-in-fetu (FIF). At laparotomy, a fetiform mass covered with fatty tissue was delivered out of a retroperitoneally located sac (in the bed of stomach). The fetiform mass had an identifiable upper limb bearing digits, one of them also bearing nail. Though histopathological examination did not reveal the presence of vertebral bodies, an advanced differentiation of the bony ends, bearing cartilage qualified the mass as FIF. There was family history of twinning with the elder siblings being dizygotic twins. The origin and diagnostic criteria of FIF are discussed and reference is made to a high likelihood of a twinning as the preceding event in this case.

Published
2011
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39. Thermal conductivity of metal-metal microlaminate composites

Author

Radhakrishna, M. C, Doerr, H. J, Deshpandey, C. V, and Bunshah, R. F

Subjects
Composite Materials
Abstract

Microlaminate composites consisting of alternate layers of metal-metal, metal-ceramic and ceramic-ceramic exhibit anisotropy in thermal conductivity. Thermal conductivity in the direction perpendicular to the laminate plane is significantly lower than in the plane of the laminate. Results of the study on thermal conductivity of Ni-NiCoCrAlY and Ti-CoCrAlY microlaminate composites are presented. A semi-quantitative model explaining the thermal conductivity variation in the above systems as a function of number of layers is discussed. An expression correlating the experimental data with the calculated data for the above system is presented.

Published
1989

40. Thin film molybdenum silicide as potential temperature sensors for turbine engines

Author

Ho, C. H, Prakash, S, Deshpandey, C. V, Doerr, H. J, and Bunshah, R. F

Subjects
Instrumentation And Photography
Abstract

Temperature measurements of Mo-Si-based thin-film resistance thermometers were studied. Annealing in an argon ambient at a temperature above 1000 C for at least 1 h is required to form the stable tetragonal MoSi2 phase. With a crack-free 2-micron-thick AlN barrier layer on top, a sensor was tested up to 1200 C. The resistivity vs temperature characteristic shows the room temperature resistivity and temperature coefficient of resistivity (TCR) of the sensor to be approximately 350 microohm and 0.01195 K, respectively. No film adhesion problems were observed for at least four testing cycles.

Published
1989

41. Microlaminate composites as thermal barrier coatings

Author

Radhakrishna, M. C, Doerr, H. J, Deshpandey, C. V, and Bunshah, R. F

Subjects
Composite Materials
Abstract

Thick multiple-layered Ni/NiCoCrAlY and Ti/CoCrAlY microlaminate composites are explored as thermal barrier coatings. The method of fabrication of these laminates and the measurement technique used to determine thermal diffusivity and thermal conductivity of these coatings are discussed. Results indicate that the thermal conductivity of the laminate composite perpendicular to the laminate plane decreases with increasing number of interfaces; the drop in thermal conductivity is likely to be associated with interfaces which act as a barrier to the transfer of heat across them; the variation in thermal conductivity with the number of interfaces is not linear.

Published
1988

42. Pretreatment effects on the morphology and properties of aluminum oxide thermally grown on NiCoCrAlY

Author

Prakash, S, Budhani, R, Doerr, H. J, Deshpandey, C. V, and Bunshah, R. F

Subjects
Nonmetallic Materials
Abstract

The effect of pretreatments on the morphology and properties of aluminum oxide thermally grown from NiCoCrAlY was investigated. The goal was to optimize process steps to produce a highly adherent, continuous, and insulating aluminum oxide. Two pretreatments were carried out, one in vacuum (about 0.0001 Torr) at 1350 K for 5 h, and the other consisting of deposition of a 1-micron thick Al2O3 film by activated reactive evaporation. Samples were subsequently oxidized thermally at 1000 C for 50 h at 0.5 Torr oxygen pressure. The two pretreatments were carried out on electron-beam evaporation NiCoCrAlY, about 120 microns thick, deposited on a superalloy turbine blade substrate. The results showed that the thermally grown oxide was significantly different in microstructure, surface topography and in its adherence to the NiCoCrAlY for the two pretreatments. Optimum results were obtained by combining the two pretreatments to produce an adherent, continuous, and insulating oxide film on the NiCoCrAlY-coated superalloy substrate.

Published
1985
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43. Microlaminate composites: An alternate approach to thermal barrier coatings

Author

Bunshah, R. F, Deshpandey, C. V, and Obrien, B. P

Subjects
Nonmetallic Materials
Abstract

Ceramic thermal barrier coatings suffer from a major drawback, i.e., brittle behavior. An alternate approach is microlaminate composite coatings consisting of alternate layers of metal and oxide. As the thickness of the individual laminae decrease while keeping the total thickness of the coating constant, the thermal conductivity drops markedly. Data on the Fe-Cu system will be presented. A model is proposed for an MCrAlY-Al2O3 microlaminate coating for thermal barriers. The methods of fabrication will also be discussed.

Published
1985

44. Effect of sandblasting on fracture load of titanium ceramic crowns.

Author

Moldi, Arvind I., Bhandari, Kishor Singh, Nagral, Sharanbassapa, Deshpandey, Sumit, and Kulkarni, Pawan

Subjects
DENTAL crowns, DENTAL veneers, DENTAL materials, TITANIUM, SAND blasting
Abstract

Purpose of the Study: It is difficult to achieve a reliable bond between the titanium and veneering porcelain. The aim of this study was to evaluate the bond strength between titanium ceramic crowns. Materials and Methods: The surfaces of titanium copings were divided in two groups. Group A sandblasted with 250 um (n = 10) and Group B without sandblasting (n = 10). Low-fusing porcelain was bonded over copings. A universal testing machine was used to determine the fracture load (N) of the crowns. All data were compared using Student's t-test. Results: There was a significant difference in fracture toughness between two groups (P = 0.05). The mean value of fracture strength for Group A was 721.66 N and for Group B was 396.39 N. Conclusions: Sandblasting improves the bond strength between titanium, and ceramic, mechanical bonding plays a crucial role in the bonding between titanium and ceramic. [ABSTRACT FROM AUTHOR]

Published
2015
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