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4 results on '"Daniel P. Brooke"'

1. Control of Zootechnology Leads to Improved Cuttlefish (Sepia officinalis, L.) Reproduction Performance up to Pre-industrial Levels

Author

Juan C. Capaz, Daniel Hernández-Brooke, Safia Balvet, Ana T. Couto, Alexandra C. Alves, Rui A. Gonçalves, Paulo A. Frias, José P. Andrade, and António V. Sykes

Subjects
broodstock, egg price, European cuttlefish (Sepia officinalis), fecundity, fertility, reproduction improvement, Science, General. Including nature conservation, geographical distribution, QH1-199.5
Abstract

Cephalopods are gaining momentum as an alternate group for aquaculture species diversification, not only because they are a good food source (highly appreciated in some worldwide markets) but they also have the potential to quickly reach a market size. However, there are some bottlenecks impeding the transition of culture technology from the laboratory to industry. One is related to control over reproduction in captivity. The objective of the present experiment was to verify the effects of tanks with different bottom areas/volumes on the reproduction performance of S. officinalis breeding stocks, when sex ratios were controlled a priori; and the food cost associated with such performance when individuals are fed a natural frozen diet. One hundred and ninety two juvenile cuttlefish were used to compare three different round-shaped tanks: one type with 3000L volume and two types with 9000L volume (with differences in bottom areas and water column). Individuals had their sex and maturity stage determined to establish a sexual ratio of 2♀:1♂ per tank and assure that cuttlefish were still immature. Biological data was collected during both growth and reproduction stages and until the death of all females in each tank. The experiment lasted nearly 300 days. Temperature differences between tank types were registered during both stages. The optimizing of rearing conditions has allowed for higher growth and a higher amount of cuttlefish available for breeding purposes. A total of 123,751 eggs (in 85 batches) was obtained during this experiment, which is a number that may meet a small scale cuttlefish commercial hatchery facility requirements. The present conditions contributed to a better and predictable reproduction performance in specific 9000L tanks, with values reaching pre-industrial numbers (≈ 24,000 eggs/tank). Moreover, both the amount of eggs per batch and the overall quality of eggs has increased. Three of these 9000L tanks have an overall consumption of ≈ 38.64 Kg tank–1, which translates in an investment in feed of ≈ 193 € tank–1, 8.40 € per cuttlefish and an overall daily tank expense of 1.76 € d–1.

Published
2020
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2. Insights into the Spectrum of Activity and Mechanism of Action of MGB-BP-3

Author

Charlotte Hind, Melanie Clifford, Charlotte Woolley, Jane Harmer, Leah M. C. McGee, Izaak Tyson-Hirst, Henry J. Tait, Daniel P. Brooke, Stephanie J. Dancer, Iain S. Hunter, Colin J. Suckling, Rebecca Beveridge, John A. Parkinson, J. Mark Sutton, and Fraser J. Scott

Subjects
Infectious Diseases
Abstract

MGB-BP-3 is a potential first-in-class antibiotic, a Strathclyde Minor Groove Binder (S-MGB), that has successfully completed Phase IIa clinical trials for the treatment of

Published
2022
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3. Truncated S-MGBs: towards a parasite-specific and low aggregation chemotype†

Author

Fraser J. Scott, Abedawn I. Khalaf, C. D. Shaw, Jasmine M. Cross, Colin J. Suckling, Kirsten Gillingwater, Craig Irving, Katharine C. Carter, Michael P. Barrett, Federica Giordani, Daniel P. Brooke, and Leah M. C. McGee

Subjects
Antiparasitic, medicine.drug_class, Pharmaceutical Science, Biochemistry, 03 medical and health sciences, chemistry.chemical_compound, Drug Discovery, medicine, Parasite hosting, QD, Truncation (statistics), 030304 developmental biology, Pharmacology, 0303 health sciences, Natural product, biology, Chemotype, 030306 microbiology, Organic Chemistry, Leishmania, biology.organism_classification, Chemistry, chemistry, Molecular Medicine, Lead compound, Bacteria
Abstract

This paper describes the design and synthesis of Strathclyde minor groove binders (S-MGBs) that have been truncated by the removal of a pyrrole ring in order to mimic the structure of the natural product, disgocidine. S-MGBs have been found to be active against many different organisms, however, selective antiparasitic activity is required. A panel of seven truncated S-MGBs was prepared and the activities examined against a number of clinically relevant organisms including several bacteria and parasites. The effect of the truncation strategy on S-MGB aggregation in aqueous environment was also investigated using 1H inspection and DOSY experiments. A lead compound, a truncated S-MGB, which possesses significant activity only against trypanosomes and Leishmania has been identified for further study and was also found to be less affected by aggregation compared to its full-length analogue., This paper describes the design and synthesis of Strathclyde minor groove binders (S-MGBs) that have been truncated by the removal of a pyrrole ring in order to mimic the structure of the natural product, disgocidine.

Published
2021

4. Correction: Truncated S-MGBs: towards a parasite-specific and low aggregation chemotype

Author

Katharine C. Carter, Michael P. Barrett, Leah M. C. McGee, Federica Giordani, Colin J. Suckling, Daniel P. Brooke, C. D. Shaw, Fraser Scott, Craig Irving, Abedawn I. Khalaf, Kirsten Gillingwater, and Jasmine M. Cross

Subjects
Pharmacology, Genetics, biology, Chemotype, Organic Chemistry, Pharmaceutical Science, Biochemistry, Chemistry, Drug Discovery, biology.protein, Molecular Medicine, Parasite hosting, QD, Chromatin structure remodeling (RSC) complex
Abstract

This paper describes the design and synthesis of Strathclyde minor groove binders (S-MGBs) that have been truncated by the removal of a pyrrole ring in order to mimic the structure of the natural product, disgocidine. S-MGBs have been found to be active against many different organisms, however, selective antiparasitic activity is required. A panel of seven truncated S-MGBs was prepared and the activities examined against a number of clinically relevant organisms including several bacteria and parasites. The effect of the truncation strategy on S-MGB aggregation in aqueous environment was also investigated using 1H inspection and DOSY experiments. A lead compound, a truncated S-MGB, which possesses significant activity only against trypanosomes and

Published
2021

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