225 results on '"Cummings B"'
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2. New insights into the genetic etiology of Alzheimer's disease and related dementias
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Bellenguez, C., Küçükali, F., Jansen, I. E., Kleineidam, L., Moreno-Grau, S., Amin, N., Naj, A. C., Campos-Martin, R., Grenier-Boley, B., Andrade, V., Holmans, P. A., Boland, A., Damotte, V., van der Lee, S. J., Costa, M. R., Kuulasmaa, T., Yang, Q., de Rojas, I., Bis, J. C., Yaqub, A., Prokic, I., Chapuis, J., Ahmad, S., Giedraitis, V., Aarsland, D., Garcia-Gonzalez, P., Abdelnour, C., Alarcón-Martín, E., Alcolea, D., Alegret, M., Alvarez, I., Álvarez, V., Armstrong, N. J., Tsolaki, A., Antúnez, C., Appollonio, I., Arcaro, M., Archetti, S., Pastor, A. A., Arosio, B., Athanasiu, L., Bailly, H., Banaj, N., Baquero, M., Barral, S., Beiser, A., Pastor, A. B., Below, J. E., Benchek, P., Benussi, L., Berr, C., Besse, C., Bessi, V., Binetti, G., Bizarro, A., Blesa, R., Boada, M., Boerwinkle, E., Borroni, B., Boschi, S., Bossù, P., Bråthen, G., Bressler, J., Bresner, C., Brodaty, H., Brookes, K. J., Brusco, L. I., Buiza-Rueda, D., Bûrger, K., Burholt, V., Bush, W. S., Calero, M., Cantwell, L. B., Chene, G., Chung, J., Cuccaro, M. L., Carracedo, Á., Cecchetti, R., Cervera-Carles, L., Charbonnier, C., Chen, H. -H., Chillotti, C., Ciccone, S., Claassen, J. A. H. R., Clark, C., Conti, E., Corma-Gómez, A., Costantini, E., Custodero, C., Daian, D., Dalmasso, M. C., Daniele, A., Dardiotis, E., Dartigues, J. -F., de Deyn, P. P., de Paiva Lopes, K., de Witte, L. D., Debette, S., Deckert, J., del Ser, T., Denning, N., Destefano, A., Dichgans, M., Diehl-Schmid, J., Diez-Fairen, M., Rossi, P. D., Djurovic, S., Duron, E., Düzel, E., Dufouil, C., Eiriksdottir, G., Engelborghs, S., Escott-Price, V., Espinosa, A., Ewers, M., Faber, K. M., Fabrizio, T., Nielsen, S. F., Fardo, D. W., Farotti, L., Fenoglio, C., Fernández-Fuertes, M., Ferrari, R., Ferreira, C. B., Ferri, E., Fin, B., Fischer, P., Fladby, T., Fließbach, K., Fongang, B., Fornage, M., Fortea, J., Foroud, T. M., Fostinelli, S., Fox, N. C., Franco-Macías, E., Bullido, M. J., Frank-García, A., Froelich, L., Fulton-Howard, B., Galimberti, D., García-Alberca, J. M., García-González, P., Garcia-Madrona, S., Garcia-Ribas, G., Ghidoni, R., Giegling, I., Giorgio, G., Goate, A. M., Goldhardt, O., Gomez-Fonseca, D., González-Pérez, A., Graff, C., Grande, G., Green, E., Grimmer, T., Grünblatt, E., Grunin, M., Gudnason, V., Guetta-Baranes, T., Haapasalo, A., Hadjigeorgiou, G., Haines, J. L., Hamilton-Nelson, K. L., Hampel, H., Hanon, O., Hardy, J., Hartmann, A. M., Hausner, L., Harwood, J., Heilmann-Heimbach, S., Helisalmi, S., Heneka, M. T., Hernández, I., Herrmann, M. J., Hoffmann, P., Holmes, C., Holstege, H., Vilas, R. H., Hulsman, M., Humphrey, J., Biessels, G. J., Jian, X., Johansson, C., Jun, G. R., Kastumata, Y., Kauwe, J., Kehoe, P. G., Kilander, L., Ståhlbom, A. K., Kivipelto, M., Koivisto, A., Kornhuber, J., Kosmidis, M. H., Kukull, W. A., Kuksa, P. P., Kunkle, B. W., Kuzma, A. B., Lage, C., Laukka, E. J., Launer, L., Lauria, A., Lee, C. -Y., Lehtisalo, J., Lerch, O., Lleó, A., Longstreth, W., Lopez, O., de Munain, A. L., Love, S., Löwemark, M., Luckcuck, L., Lunetta, K. L., Ma, Y., Macías, J., Macleod, C. A., Maier, W., Mangialasche, F., Spallazzi, M., Marquié, M., Marshall, R., Martin, E. R., Montes, A. M., Rodríguez, C. M., Masullo, C., Mayeux, R., Mead, S., Mecocci, P., Medina, M., Meggy, A., Mehrabian, S., Mendoza, S., Menéndez-González, M., Mir, P., Moebus, S., Mol, M., Molina-Porcel, L., Montrreal, L., Morelli, L., Moreno, F., Morgan, K., Mosley, T., Nöthen, M. M., Muchnik, C., Mukherjee, S., Nacmias, B., Ngandu, T., Nicolas, G., Nordestgaard, B. G., Olaso, R., Orellana, A., Orsini, M., Ortega, G., Padovani, A., Paolo, C., Papenberg, G., Parnetti, L., Pasquier, F., Pastor, P., Peloso, G., Pérez-Cordón, A., Pérez-Tur, J., Pericard, P., Peters, O., Pijnenburg, Y. A. L., Pineda, J. A., Piñol-Ripoll, G., Pisanu, C., Polak, T., Popp, J., Posthuma, D., Priller, J., Puerta, R., Quenez, O., Quintela, I., Thomassen, J. Q., Rábano, A., Rainero, I., Rajabli, F., Ramakers, I., Real, L. M., Reinders, M. J. T., Reitz, C., Reyes-Dumeyer, D., Ridge, P., Riedel-Heller, S., Riederer, P., Roberto, N., Rodriguez-Rodriguez, E., Rongve, A., Allende, I. R., Rosende-Roca, M., Royo, J. L., Rubino, E., Rujescu, D., Sáez, M. E., Sakka, P., Saltvedt, I., Sanabria, Á., Sánchez-Arjona, M. B., Sanchez-Garcia, F., Juan, P. S., Sánchez-Valle, R., Sando, S. B., Sarnowski, C., Satizabal, C. L., Scamosci, M., Scarmeas, N., Scarpini, E., Scheltens, P., Scherbaum, N., Scherer, M., Schmid, M., Schneider, A., Schott, J. M., Selbæk, G., Seripa, D., Serrano, M., Sha, J., Shadrin, A. A., Skrobot, O., Slifer, S., Snijders, G. J. L., Soininen, H., Solfrizzi, V., Solomon, A., Song, Y. E., Sorbi, S., Sotolongo-Grau, O., Spalletta, G., Spottke, A., Squassina, A., Stordal, E., Tartan, J. P., Tárraga, L., Tesí, N., Thalamuthu, A., Thomas, T., Tosto, G., Traykov, L., Tremolizzo, L., Tybjærg-Hansen, A., Uitterlinden, A., Ullgren, A., Ulstein, I., Valero, S., Valladares, O., Broeckhoven, C. V., Vance, J., Vardarajan, B. N., van der Lugt, A., Dongen, J. V., van Rooij, J., van Swieten, J., Vandenberghe, R., Verhey, F., Vidal, J. -S., Vogelgsang, J., Vyhnalek, M., Wagner, M., Wallon, D., Wang, L. -S., Wang, R., Weinhold, L., Wiltfang, J., Windle, G., Woods, B., Yannakoulia, M., Zare, H., Zhao, Y., Zhang, X., Zhu, C., Zulaica, M., Laczo, J., Matoska, V., Serpente, M., Assogna, F., Piras, F., Ciullo, V., Shofany, J., Ferrarese, C., Andreoni, S., Sala, G., Zoia, C. P., Zompo, M. D., Benussi, A., Bastiani, P., Takalo, M., Natunen, T., Laatikainen, T., Tuomilehto, J., Antikainen, R., Strandberg, T., Lindström, J., Peltonen, M., Abraham, R., Al-Chalabi, A., Bass, N. J., Brayne, C., Brown, K. S., Collinge, J., Craig, D., Deloukas, P., Fox, N., Gerrish, A., Gill, M., Gwilliam, R., Harold, D., Hollingworth, P., Johnston, J. A., Jones, L., Lawlor, B., Livingston, G., Lovestone, S., Lupton, M., Lynch, A., Mann, D., Mcguinness, B., Mcquillin, A., O’Donovan, M. C., Owen, M. J., Passmore, P., Powell, J. F., Proitsi, P., Rossor, M., Shaw, C. E., Smith, A. D., Gurling, H., Todd, S., Mummery, C., Ryan, N., Lacidogna, G., Adarmes-Gómez, A., Mauleón, A., Pancho, A., Gailhajenet, A., Lafuente, A., Macias-García, D., Martín, E., Pelejà, E., Carrillo, F., Merlín, I. S., Garrote-Espina, L., Vargas, L., Carrion-Claro, M., Marín, M., Labrador, M., Buendia, M., Alonso, M. 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E., Mars, N., Pelkonen, M., Kauppi, P., Kankaanranta, H., Harju, T., Close, D., Greenberg, S., Chen, H., Betts, J., Ghosh, S., Salomaa, V., Niiranen, T., Juonala, M., Metsärinne, K., Kähönen, M., Junttila, J., Laakso, M., Pihlajamäki, J., Sinisalo, J., Taskinen, M. -R., Tuomi, T., Challis, B., Peterson, A., Chu, A., Parkkinen, J., Muslin, A., Joensuu, H., Meretoja, T., Aaltonen, L., Mattson, J., Auranen, A., Karihtala, P., Kauppila, S., Auvinen, P., Elenius, K., Popovic, R., Schutzman, J., Loboda, A., Chhibber, A., Lehtonen, H., Mcdonough, S., Crohns, M., Kulkarni, D., Kaarniranta, K., Turunen, J. A., Ollila, T., Seitsonen, S., Uusitalo, H., Aaltonen, V., Uusitalo-Järvinen, H., Luodonpää, M., Hautala, N., Loomis, S., Strauss, E., Podgornaia, A., Hoffman, J., Tasanen, K., Huilaja, L., Hannula-Jouppi, K., Salmi, T., Peltonen, S., Koulu, L., Harvima, I., Wu, Y., Choy, D., Pussinen, P., Salminen, A., Salo, T., Rice, D., Nieminen, P., Palotie, U., Siponen, M., Suominen, L., Mäntylä, P., Gursoy, U., Anttonen, V., Sipilä, K., Davis, J. W., Quarless, D., Petrovski, S., Wigmore, E., Chen, C. -Y., Bronson, P., Tsai, E., Huang, Y., Maranville, J., Shaikho, E., Mohammed, E., Wadhawan, S., Kvikstad, E., Caliskan, M., Chang, D., Bhangale, T., Pendergrass, S., Holzinger, E., Chen, X., Hedman, Å., King, K. S., Wang, C., Xu, E., Auge, F., Chatelain, C., Rajpal, D., Liu, D., Xia, T. -H., Brauer, M., Kurki, M., Karjalainen, J., Havulinna, A., Jalanko, A., Palta, P., della Briotta Parolo, P., Zhou, W., Lemmelä, S., Rivas, M., Harju, J., Lehisto, A., Ganna, A., Llorens, V., Laivuori, H., Rüeger, S., Niemi, M. E., Tukiainen, T., Reeve, M. P., Heyne, H., Palin, K., Garcia-Tabuenca, J., Siirtola, H., Kiiskinen, T., Lee, J., Tsuo, K., Elliott, A., Kristiansson, K., Hyvärinen, K., Ritari, J., Koskinen, M., Pylkäs, K., Kalaoja, M., Karjalainen, M., Mantere, T., Kangasniemi, E., Heikkinen, S., Laakkonen, E., Sipeky, C., Heron, S., Karlsson, A., Jambulingam, D., Rathinakannan, V. S., Kajanne, R., Aavikko, M., Jiménez, M. G., della Briotta Parola, P., Kanai, M., Kaunisto, M., Kilpeläinen, E., Sipilä, T. 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I., Li, M., Lieberman, A. P., Lipton, R. B., Logue, M., Lyketsos, C. G., Malamon, J., Mains, D., Marson, D. C., Martiniuk, F., Mash, D. C., Masliah, E., Massman, P., Masurkar, A., Mccormick, W. C., Mccurry, S. M., Mcdavid, A. N., Mckee, A. C., Mesulam, M., Mez, J., Miller, B. L., Miller, C. A., Miller, J. W., Montine, T. J., Monuki, E. S., Morris, J. C., Myers, A. J., Nguyen, T., O’Bryant, S., Olichney, J. M., Ory, M., Palmer, R., Parisi, J. E., Paulson, H. L., Pavlik, V., Paydarfar, D., Perez, V., Peskind, E., Petersen, R. C., Phillips-Cremins, J. E., Pierce, A., Polk, M., Poon, W. W., Potter, H., Qu, L., Quiceno, M., Quinn, J. F., Raj, A., Raskind, M., Reiman, E. M., Reisberg, B., Reisch, J. S., Ringman, J. M., Roberson, E. D., Rodriguear, M., Rogaeva, E., Rosen, H. J., Rosenberg, R. N., Royall, D. R., Sager, M. A., Sano, M., Saykin, A. J., Schneider, J. A., Schneider, L. S., Seeley, W. W., Small, S., Smith, A. G., Smith, J. P., Sonnen, J. A., Spina, S., George-Hyslop, P. 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Uitterlinden, A, Ullgren, A, Ulstein, I, Valero, S, Valladares, O, Broeckhoven, C, Vance, J, Vardarajan, B, van der Lugt, A, Dongen, J, van Rooij, J, van Swieten, J, Vandenberghe, R, Verhey, F, Vidal, J, Vogelgsang, J, Vyhnalek, M, Wagner, M, Wallon, D, Wang, L, Wang, R, Weinhold, L, Wiltfang, J, Windle, G, Woods, B, Yannakoulia, M, Zare, H, Zhao, Y, Zhang, X, Zhu, C, Zulaica, M, Andreoni, S, Ferrarese, C, Sala, G, Zoia, C, Farrer, L, Psaty, B, Ghanbari, M, Raj, T, Sachdev, P, Mather, K, Jessen, F, Ikram, M, de Mendonça, A, Hort, J, Tsolaki, M, Pericak-Vance, M, Amouyel, P, Williams, J, Frikke-Schmidt, R, Clarimon, J, Deleuze, J, Rossi, G, Seshadri, S, Andreassen, O, Ingelsson, M, Hiltunen, M, Sleegers, K, Schellenberg, G, van Duijn, C, Sims, R, van der Flier, W, Ruiz, A, Ramirez, A, Lambert, J, VU University medical center, Amsterdam Neuroscience - Neurodegeneration, Neurology, Human genetics, Amsterdam Neuroscience - Complex Trait Genetics, Amsterdam Neuroscience - Compulsivity, 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Sachdev, Perminder [0000-0002-9595-3220], Mather, Karen [0000-0003-4143-8941], Ikram, M Arfan [0000-0003-0372-8585], Tsolaki, Magda [0000-0002-2072-8010], Pericak-Vance, Margaret A [0000-0001-7283-8804], Amouyel, Philippe [0000-0001-9088-234X], Williams, Julie [0000-0002-4069-0259], Frikke-Schmidt, Ruth [0000-0003-4084-5027], Seshadri, Sudha [0000-0001-6135-2622], Andreassen, Ole A [0000-0002-4461-3568], Sleegers, Kristel [0000-0002-0283-2332], van Duijn, Cornelia M [0000-0002-2374-9204], Sims, Rebecca [0000-0002-3885-1199], van der Flier, Wiesje M [0000-0001-8766-6224], Ramirez, Alfredo [0000-0003-4991-763X], Lambert, Jean-Charles [0000-0003-0829-7817], Apollo - University of Cambridge Repository, Complex Trait Genetics, Clinical sciences, Neuroprotection & Neuromodulation, Pathologic Biochemistry and Physiology, Clinical Biology, Epidemiology, Internal Medicine, Psychiatrie & Neuropsychologie, RS: MHeNs - R1 - Cognitive Neuropsychiatry and Clinical Neuroscience, MUMC+: MA Med Staf Spec Psychiatrie (9), UAM. Departamento de Biología Molecular, University of Helsinki, Department of Neurosciences, HUS Internal Medicine and Rehabilitation, Timo Strandberg / Principal Investigator, Department of Medicine, Clinicum, HUS Neurocenter, Neurologian yksikkö, Centre of Excellence in Complex Disease Genetics, HUS Abdominal Center, Institut Pasteur, Institut National de la Santé et de la Recherche Médicale (France), European Commission, LabEx DISTALZ, Pérez-Tur, Jordi, University Children’s Hospital Basel (Suiza), INSERM (Francia), Lille Métropole Communauté Urbaine, Government of France (Francia), EADB, GR@ACE, DEGESCO, EADI, GERAD, Demgene, FinnGen, ADGC, CHARGE, Holmans, Peter A. [0000-0003-0870-9412], van der Lee, Sven J. [0000-0003-1606-8643], Costa, Marcos R. [0000-0002-4928-2163], Bis, Joshua C. [0000-0002-3409-1110], Brookes, Keeley J. [0000-0003-2427-2513], Bush, William S. [0000-0002-9729-6519], de Witte, Lot D. [0000-0002-7235-9958], del Ser, Teodoro [0000-0001-9806-7083], Fox, Nick C. [0000-0002-6660-657X], Bullido, María J. [0000-0002-6477-1117], Goate, Alison M. [0000-0002-0576-2472], Herrmann, Martin J. [0000-0001-9970-2122], Jun, Gyungah R. [0000-0002-3230-8697], Kehoe, Patrick G. [0000-0002-7542-1139], Kosmidis, Mary H. [0000-0001-8790-1220], Lunetta, Kathryn L. [0000-0002-9268-810X], MacLeod, Catherine A. [0000-0002-9314-7380], Nöthen, Markus M. [0000-0002-8770-2464], Nordestgaard, Børge G. [0000-0002-1954-7220], Pineda, Juan A. [0000-0002-3751-0296], Real, Luis M. [0000-0003-4932-7429], Reinders, Marcel J. T. [0000-0002-1148-1562], Satizabal, Claudia L. [0000-0002-1115-4430], Schott, Jonathan M. [0000-0003-2059-024X], Shadrin, Alexey A. [0000-0002-7467-250X], Farrer, Lindsay A. [0000-0001-5533-4225], Psaty, Bruce M. [0000-0002-7278-2190], Ikram, M. Arfan [0000-0003-0372-8585], Pericak-Vance, Margaret A. [0000-0001-7283-8804], Andreassen, Ole A. [0000-0002-4461-3568], van Duijn, Cornelia M. [0000-0002-2374-9204], van der Flier, Wiesje M. [0000-0001-8766-6224], and Molecular Neuroscience and Ageing Research (MOLAR)
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tau Proteins/genetics ,Alzheimer`s disease Donders Center for Medical Neuroscience [Radboudumc 1] ,Neurologi ,MED/03 - GENETICA MEDICA ,45/43 ,Medizin ,Stress-related disorders Donders Center for Medical Neuroscience [Radboudumc 13] ,genetics [Alzheimer Disease] ,Genome-Wide Association Study ,Humans ,tau Proteins ,Alzheimer Disease ,Cognitive Dysfunction ,VARIANTS ,pathology [Alzheimer Disease] ,Tau Proteins ,Settore BIO/13 - Biologia Applicata ,Cognitive Dysfunction/psychology ,692/699/375/365/1283 ,IMPUTATION ,article ,1184 Genetics, developmental biology, physiology ,Biología y Biomedicina / Biología ,AMYLOID-BETA ,Settore MED/26 - NEUROLOGIA ,Neurology ,psychology [Cognitive Dysfunction] ,Medical Genetics ,Human ,Neuroscience(all) ,631/208/205/2138 ,All institutes and research themes of the Radboud University Medical Center ,SDG 3 - Good Health and Well-being ,ddc:570 ,Genetics ,Genetic Predisposition to Disease ,GENOME-WIDE ASSOCIATION ,METAANALYSIS ,Medicinsk genetik ,MED/26 - NEUROLOGIA ,Alzheimer Disease/genetics ,neurology ,tau Protein ,NECROSIS-FACTOR-ALPHA ,RISK LOCI ,genetics [tau Proteins] ,PREDICTION MODELS ,Human medicine ,GENERATION ,RESPONSES - Abstract
25 páginas, 6 figuras, 2 tablas, Characterization of the genetic landscape of Alzheimer's disease (AD) and related dementias (ADD) provides a unique opportunity for a better understanding of the associated pathophysiological processes. We performed a two-stage genome-wide association study totaling 111,326 clinically diagnosed/'proxy' AD cases and 677,663 controls. We found 75 risk loci, of which 42 were new at the time of analysis. Pathway enrichment analyses confirmed the involvement of amyloid/tau pathways and highlighted microglia implication. Gene prioritization in the new loci identified 31 genes that were suggestive of new genetically associated processes, including the tumor necrosis factor alpha pathway through the linear ubiquitin chain assembly complex. We also built a new genetic risk score associated with the risk of future AD/dementia or progression from mild cognitive impairment to AD/dementia. The improvement in prediction led to a 1.6- to 1.9-fold increase in AD risk from the lowest to the highest decile, in addition to effects of age and the APOE ε4 allele., This work was funded by a grant (EADB) from the EU Joint Programme – Neurodegenerative Disease Research. INSERM UMR1167 is also funded by the INSERM, Institut Pasteur de Lille, Lille Métropole Communauté Urbaine and French government’s LABEX DISTALZ program (development of innovative strategies for a transdisciplinary approach to AD). Full consortium acknowledgements and funding are in the Supplementary Not
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- 2022
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3. Approaches to end-of-life discussions with parents of a profoundly compromised newborn
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Paris, J J, Pai, V, Cummings, B M, Batten, J, and Benitz, W E
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- 2017
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4. The Charlie Gard case: British and American approaches to court resolution of disputes over medical decisions
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Paris, J J, Ahluwalia, J, Cummings, B M, Moreland, M P, and Wilkinson, D J
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- 2017
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5. Evidence for X(3872) in Pb-Pb Collisions and Studies of its Prompt Production at root s(NN)=5.02 TeV
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M., Racz, D., Rovere, M., Sakulin, M., Salfeld-Nebgen, H., Scarfi, J., Schafer, S., Schwick, C., Selvaggi, C., Sharma, M., Silva, A., Snoeys, P., Sphicas, W., Steggemann, P., Summers, J., Tavolaro, S., Treille, V. R., Tsirou, D., Van, Onsem, Vartak, G. P., Verzetti, A., Wozniak, M., Zeuner, K. A., Caminada, W. D., Deiters, L., Erdmann, K., Horisberger, W., Ingram, R., Kaestli, Q., Kotlinski, H. C., Langenegger, D., Rohe, U., Backhaus, T., Berger, M., Cal, P., Ri, A., Chernyavskaya, N., Dissertori, G., Dittmar, M., Donega, M., Dorfer, C., Espinosa, Gomez, T. A., Grab, C., Hits, D., Lustermann, W., Manzoni, R. A., Meinhard, M. T., Micheli, F., Musella, P., Nessi-Tedaldi, F., Pauss, F., Perovic, V, Perrin, G., Perrozzi, L., Pigazzini, S., Ratti, M. G., Reichmann, M., Reissel, C., Reitenspiess, T., Ristic, B., Ruini, D., Becerra, Sanz, D. A., Schonenberger, M., Shchutska, L., Olsson, Vesterbacka, M. L., Wallny, R., Zhu, D. H., Amsler, C., Botta, C., Brzhechko, D., Canelli, M. 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J., Burns, D., Clement, E., Cussans, D., Flacher, H., Goldstein, J., Heath, G. P., Heath, H. F., Kreczko, L., Krikler, B., Paramesvaran, S., Sakuma, T., Nasr-Storey, El, Seif, S., Smith, V. J., Taylor, J., Titterton, A., Bell, K. W., Brew, C., Brown, R. M., Cockerill, D. J. A., Coughlan, J. A., Harder, K., Harper, S., Linacre, J., Manolopoulos, K., Newbold, D. M., Olaiya, E., Petyt, D., Reis, T., Schuh, T., Shepherd-Themistocleous, C. H., Thea, A., Tomalin, I. R., Williams, T., Bainbridge, R., Bloch, P., Bonomally, S., Borg, J., Breeze, S., Buchmuller, O., Bundock, A., Chahal, Gurpreet, Singh, Colling, D., Dauncey, P., Davies, G., Della, Negra, Everaerts, M., Hall, P., Iles, G., Komm, G., Langford, M., Lyons, J., Magnan, L., A-M, Malik, Martelli, S., Milosevic, A., Morton, V, Nash, A., Palladino, J., Pesaresi, V, Raymond, M., Richards, D. M., Rose, A., Scott, A., Seez, E., Shtipliyski, C., Stoye, A., Strebler, M., Tapper, T., Uchida, A., Virdee, K., Wardle, T., Webb, N., Winterbottom, S. N., Zecchinelli, D., Zenz, A. G., Cole, S. C., Hobson, J. E., Khan, P. R., Kyberd, A., Mackay, P., Reid, C. K., Teodorescu, I. D., Zahid, L., Brinkerhoff, S., Call, A., Caraway, K., Dittmann, B., Hatakeyama, J., Madrid, K., Mcmaster, C., Pastika, B., Smith, N., Bartek, C., Dominguez, R., Uniyal, A., Hern, R., Vargas, A. M., Buccilli, A., Cooper, I, Gleyzer, S., V, S., Henderson, C., Rumerio, P., West, C., Albert, A., Arcaro, D., Demiragli, Z., Gastler, D., Richardson, C., Rohlf, J., Sperka, D., Spitzbart, D., Suarez, I, Sulak, L., Zou, D., Benelli, G., Burkle, B., Coubez, X., Cutts, D., Duh, Y. T., Hadley, M., Heintz, U., Hogan, J. M., Kwok, K. H. M., Laird, E., Sberg, L, Lau, G., Lee, K. T., Narain, J., Sagir, M., Syarif, S., Usai, R., Wong, E., W. Y., Yu, Zhang, D., W. B., Brainerd, R., Breedon, C., Sanchez, R., Calderon De La Barca, M., Chertok, M., Conway, J., Conway, R., Cox, P. T., Erbacher, R., Flores, C., Funk, G., Jensen, F., Ko, W., Kukral, O., L, Er, Mulhearn, R., Pellett, M., Pilot, D., Shi, J., Taylor, M., Tos, D., Tripathi, K., Wang, M., Zhang, Z., Bachtis, F., Bravo, M., Cousins, C., Dasgupta, R., Florent, A., Hauser, A., Ignatenko, J., Mccoll, M., Nash, N., Regnard, W. A., Saltzberg, S., Schnaible, D., Stone, C., Valuev, B., Burt, V., Chen, K., Clare, Y., Gary, R., Shirazi, J. W., Ghiasi, S. M. A., Hanson, G., Karapostoli, G., Long, O. R., Manganelli, N., Negrete, Olmedo, M., Paneva, I, Si, M., Wimpenny, W., Yates, S., Zhang, B. R., Branson, Y., Chang, J. G., Cittolin, P., Cooperstein, S., Deelen, S., Derdzinski, N., Duarte, M., Gerosa, J., Gilbert, R., Hashemi, D., Klein, B., Krutelyov, D., Letts, V, Masciovecchio, J., May, M., Padhi, S., Pieri, S., Tadel, V, Wurthwein, M., Yagil, F., Della, Porta, Zevi, G., Amin, N., Ari, Bh, Campagnari, R., Citron, C., Dutta, M., Inc, V, Ela, J., Marsh, B., Mei, H., Ovcharova, A., Qu, H., Richman, J., Sarica, U., Stuart, D., Wang, S., Erson, D., Bornheim, A., Cerri, O., Dutta, I, Lawhorn, J. M., Lu, N., Mao, J., Newman, H. B., Nguyen, T. Q., Pata, J., Spiropulu, M., Vlimant, J. R., Xie, S., Zhu, R. Y., Alison, J., Rews, M. B., Ferguson, T., Mudholkar, T., Paulini, M., Sun, M., Vorobiev, I, Weinberg, M., Cumalat, J. P., Ford, W. T., Macdonald, E., Mulholl, T., Patel, R., Perloff, A., Stenson, K., Ulmer, K. A., Wagner, S. R., Alex, Er, Cheng, J., Chu, Y., Datta, J., Frankenthal, A., Mcdermott, A., Patterson, K., Quach, J. R., Ryd, D., Tan, A., Tao, S. M., Thom, Z., Wittich, J., Zientek, P., Abdullin, M., Albrow, S., Alyari, M., Apollinari, M., Apresyan, G., Apyan, A., Banerjee, A., Bauerdick, S., Beretvas, L. A. T., Berry, A., Berryhill, D., Bhat, J., Burkett, P. C., Butler, K., Canepa, J. N., Cerati, A., Cheung, G. B., Chlebana, H. W. K., Cremonesi, F., Elvira, M., Freeman, V. D., Gecse, J., Gottschalk, Z., Gray, E., Green, L., Grunendahl, D., Gutsche, S., Hanlon, O., Harris, J., Hasegawa, R. M., Heller, S., Hirschauer, R., Jayatilaka, J., Jindariani, B., Johnson, S., Joshi, M., Klijnsma, U., Klima, T., Kortelainen, B., Kreis, M. J., Lammel, B., Lewis, S., Lincoln, J., Lipton, D., Liu, R., Liu, M., Lykken, T., Maeshima, J., Marraffino, K., Mason, J. M., Mcbride, D., Merkel, P., Mrenna, P., Nahn, S., O'Dell, S., Papadimitriou, V, Pedro, V, Pena, K., Ravera, C., Hall, F., Reinsvold, A., Ristori, L., Schneider, B., Sexton-Kennedy, E., Soha, A., Spalding, W. J., Spiegel, L., Stoynev, S., Strait, J., Taylor, L., Tkaczyk, S., Tran, V, Uplegger, N., Va, L., Ering, E. W., Vidal, R., Weber, H. A., Woodard, A., Acosta, D., Avery, P., Bourilkov, D., Cadamuro, L., Cherepanov, V, Errico, F., Field, R. D., Guerrero, D., Joshi, B. M., Kim, M., Konigsberg, J., Korytov, A., K. H., Lo, Matchev, K., Menendez, N., Mitselmakher, G., Rosenzweig, D., Shi, K., Wang, J., Zuo, X., Joshi, Y. R., Adams, T., Askew, A., Hagopian, S., Hagopian, V, Johnson, K. F., Khurana, R., Kolberg, T., Martinez, G., Perry, T., Prosper, H., Schiber, C., Yohay, R., Zhang, J., Baarm, M. M., Hohlmann, M., Noonan, D., Rahmani, M., Saunders, M., Yumiceva, F., Adams, M. R., Apanasevich, L., Betts, R. R., Cavanaugh, R., Chen, X., Dittmer, S., Evdokimov, O., Gerber, C. E., Hangal, D. A., Hofman, D. J., Kumar, V, Mills, C., Oh, G., Roy, T., Tonjes, M. B., Varelas, N., Viinikainen, J., Wang, H., Wang, X., Wu, Z., Alhusseini, M., Bilki, B., Dilsiz, K., Durgut, S., Rajula, G, Haytmyradov, R. P., Khristenko, M., Koseyan, V, Merlo, O. K., J-P, Mestvirishvili, Moeller, A., Nachtman, A., Ogul, J., Onel, H., Ozok, Y., Penzo, F., Snyder, A., Tiras, C., Wetzel, E., Yi, J., Blumenfeld, K., Cocoros, B., Eminizer, A., Gritsan, N., V, A., Hung, W. T., Kyriacou, S., Maksimovic, P., Mantilla, C., Roskes, J., Swartz, M., Vami, T. A., Barrera, Baldenegro, C., Baringer, P., Bean, A., Boren, S., Bylinkin, A., Isidori, T., Khalil, S., King, J., Krintiras, G., Kropivnitskaya, A., Lindsey, C., Majumder, D., Mcbrayer, W., Minafra, N., Murray, M., Rogan, C., Royon, C., Ers, S, Schmitz, S., Takaki, E., Tapia, J. D., Wang, Q., Williams, J., Wilson, G., Duric, S., Kaadze, K., Kim, D., Maravin, Y., Mendis, D. R., Mitchell, T., Modak, A., Mohammadi, A., Rebassoo, F., Wright, D., Baden, A., Baron, O., Belloni, A., Eno, S. C., Feng, Y., Hadley, N. J., Jabeen, S., Jeng, G. Y., Kellogg, R. G., Mignerey, A. C., Nabili, S., Seidel, M., Skuja, A., Tonwar, S. C., Wang, L., Wong, K., Abercrombie, D., Allen, B., Bi, R., Br, T, Busza, S., Cali, W., D'Alfonso, I. A., Ceballos, M., Gomez, G., Goncharov, M., Harris, P., Hsu, D., Klute, M., Kovalskyi, D., Lee, Y-J, Luckey, P. D., Maier, B., Marini, A. C., Mcginn, C., Mironov, C., Narayanan, S., Niu, X., Paus, C., Rankin, D., Rol, Rol, C., Shi, G., Stephans, Z., Sumorok, G. S. F., Tatar, K., Velicanu, K., Wyslouch, T. W., Chatterjee, B., Evans, R. M., Guts, A., Hansen, S., Hiltbr, P., Jain, J., Kubota, Sh, Lesko, Y., Mans, Z., Revering, J., Rusack, M., Saradhy, R., Schroeder, R., Strobbe, N., Wadud, N., Acosta, M. A., Oliveros, J. G., Bloom, S., Chauhan, K., Claes, S., Fangmeier, D. R., Finco, C., Golf, L., Kamalieddin, F., Kravchenko, R., Siado, I, Snow, J. E., Stieger, G. R., Tabb, B., Agarwal, W., Harrington, G., Iashvili, C., Kharchilava, I., Mclean, A., Nguyen, C., Parker, D., Pekkanen, A., Rappoccio, J., Roozbahani, S., Alverson, B., Barberis, G., Freer, E., Haddad, C., Hortiangtham, Y., Madigan, A., Marzocchi, G., Morse, B., Nguyen, D. M., Orimoto, V, Skinnari, T., Tishelman-Charny, L., Wamorkar, A., Wang, T., Wisecarver, B., Wood, A., Bhattacharya, D., Bueghly, S., Fedi, J., Gilbert, G., Gunter, A., Hahn, T., Odell, K. A., Schmitt, N., Sung, M. H., Velasco, K., Bucci, M., Dev, R., Goldouzian, N., Hildreth, R., Anampa, M., Hurtado, K., Jessop, C., Karmgard, D. J., Lannon, K., Li, W., Loukas, N., Marinelli, N., Mcalister, I, Meng, F., Musienko, Y., Ruchti, R., Siddireddy, P., Smith, G., Taroni, S., Wayne, M., Wightman, A., Wolf, M., Alimena, J., Bylsma, B., Cardwell, B., Durkin, L. S., Francis, B., Hill, C., Ji, W., Lefeld, A., Ling, T. Y., Winer, B. L., Dezoort, G., Elmer, P., Hardenbrook, J., Haubrich, N., Higginbotham, S., Kalogeropoulos, A., Kwan, S., Lange, D., Lucchini, M. T., Luo, J., Marlow, D., Mei, K., Ojalvo, I, Olsen, J., Palmer, C., Piroue, P., Stickl, D., Tully, C., Malik, S., Norberg, S., Barker, A., Barnes, V. E., Chawla, R., Das, S., Gutay, L., Jones, M., Jung, A. W., Mahakud, B., Miller, D. H., Negro, G., Neumeister, N., Peng, C. C., Piperov, S., Qiu, H., Schulte, J. F., Trevisani, N., Wang, F., Xiao, R., Xie, W., Cheng, T., Dolen, J., Parashar, N., Baty, A., Behrens, U., Dildick, S., Ecklund, K. M., Freed, S., Geurts, F. J. M., Kilpatrick, M., Kumar, Arun, Padley, B. P., Redjimi, R., Roberts, J., Rorie, J., Shi, W., Leiton, Stahl, A. G., Tu, Z., Zhang, A., Bodek, A., Barbaro, De, Demina, P., Dulemba, R., Fallon, J. L., Ferbel, C., Galanti, T., Garcia-Bellido, M., Hindrichs, A., Khukhunaishvili, O., Ranken, A., Taus, E., Chiarito, R., Chou, B., J. P. G., Rakota, A., Gershtein, Y., Halkiadakis, E., Hart, A., Heindl, M., Hughes, E., Kaplan, S., Laflotte, I, Lath, A., Montalvo, R., Nash, K., Osherson, M., Salur, S., Schnetzer, S., Somalwar, S., Stone, R., Thomas, S., Acharya, H., Delannoy, A. G., Spanier, S., Bouhali, O., Dalchenko, M., Mattia, De, Delgado, M., Eusebi, A., Gilmore, R., Huang, J., Kamon, T., Kim, T., Luo, H., Malhotra, S., Marley, S., Mueller, D., Overton, R., Pernie, D., Rathjens, L., Safonov, D., Akchurin, A., Damgov, N., Guio, De, Hegde, F., Kunori, V, Lamichhane, S., Mengke, S. W., Muthumuni, T., Peltola, S., Undleeb, T., Volobouev, S., Wang, I, Whitbeck, Z., Greene, A., Gurrola, S., Janjam, A., Johns, R., Maguire, W., Melo, C., Ni, A., Padeken, H., Romeo, K., Sheldon, F., Tuo, P., Velkovska, S., Verweij, J., Arenton, M., Barria, M. W., Cox, P., Cummings, B., Hakala, G., Hirosky, J., Joyce, R., Ledovskoy, M., Neu, A., Tannenwald, C., Wang, B., Wolfe, Y., Xia, E., Harr, F., Karchin, R., Poudyal, P. E., Sturdy, N., Thapa, J., Black, P., Bose, K., Buchanan, T., Caillol, J., Carlsmith, C., Dasu, D., Bruyn, De, Dodd, I, Galloni, L., He, C., Herndon, H., Herve, M., Hussain, A., Lanaro, U., Loeliger, A., Loveless, A., Sreekala, R., Madhusudanan, J., Mallampalli, A., Pinna, D., Ruggles, T., Savin, A., Sharma, V, Smith, W. H., Teague, D., Trembath-reichert, S., and Cms, Collaboration
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MODEL ,Physics and Astronomy ,High Energy Physics::Experiment ,QUARK-GLUON PLASMA ,Nuclear Experiment - Abstract
The first evidence for X(3872) production in relativistic heavy ion collisions is reported. The X(3872) production is studied in lead-lead (Pb-Pb) collisions at a center-of-mass energy of root s(NN) = 5.02 TeV per nucleon pair, using the decay chain X(3872) -> J/psi pi(+)pi(-) -> mu(+) mu(-) pi(+)pi(-). The data were recorded with the CMS detector in 2018 and correspond to an integrated luminosity of 1.7 nb(-1). The measurement is performed in the rapidity and transverse momentum ranges vertical bar y vertical bar < 1.6 and 15 < p(T) < 50 GeV/c. The significance of the inclusive X(3872) signal is 4.2 standard deviations. The prompt X(3872) to psi 2S yield ratio is found to be rho(Pb-Pb) = 1.08 +/- 0.49(stat) +/- 0.52(syst), to be compared with typical values of 0.1 for pp collisions. This result provides a unique experimental input to theoretical models of the X(3872) production mechanism, and of the nature of this exotic state.
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- 2022
6. Single-cell Chromatin Accessibility and Lipid Profiling Reveals a Metabolic Shift in Adipocytes Induced by Bariatric Surgery
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Roman Spektor, Paul D. Soloway, Thomas Brenna J, Park Hg, Cummings B, and Harlan B
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chemistry.chemical_classification ,medicine.medical_specialty ,biology ,Glucose uptake ,Fatty acid ,Adipose tissue ,Type 2 diabetes ,medicine.disease ,Energy homeostasis ,Chromatin ,Fatty acid desaturase ,Insulin resistance ,Endocrinology ,chemistry ,Internal medicine ,parasitic diseases ,biology.protein ,medicine - Abstract
Obesity promotes type 2 diabetes and cardiometabolic pathologies. Vertical sleeve gastrectomy (VSG) is used to treat obesity resulting in long-term weight loss and health improvements that precede weight loss; however, the mechanisms underlying the immediate benefits remain incompletely understood. Because adipose plays a crucial role in energy homeostasis and utilization, we hypothesized that VSG exerts its influences, in part, by modulating adipose functional states. We applied single-cell ATAC sequencing and lipid profiling to inguinal and epididymal adipose depots from mice that received sham surgery or VSG. We observed depot-specific cellular composition and chromatin accessibility patterns that were altered by VSG. Specifically, accessibility at Scd1, a fatty acid desaturase, was substantially reduced after VSG in mature adipocytes of inguinal but not epididymal depots. This was accompanied by reduced accumulation of SCD1-produced unsaturated fatty acids. Given these findings and reports that reductions in Scd1 attenuate obesity and insulin resistance and that unsaturated fatty acids stimulate glucose uptake, storage, and oxidation, our results suggest VSG exerts its beneficial effects through modifications of fatty acid profiles mediated by Scd1.
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- 2021
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7. Loss of coupling between calcium influx, energy consumption and insulin secretion associated with development of hyperglycaemia in the UCD-T2DM rat model of type 2 diabetes
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Rountree, A. M., Reed, B. J., Cummings, B. P., Jung, S.-R., Stanhope, K. L., Graham, J. L., Griffen, S. C., Hull, R. L., Havel, P. J., and Sweet, I. R.
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- 2013
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8. Howe v. MGH and Hudson v. Texas Children's Hospital: two approaches to resolving family–physician disputes in end-of-life care
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Paris, J J, Billinngs, J A, Cummings, B, and Moreland, M P
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- 2006
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9. 151 Feasibility of using MRI-based outcomes for quality indicators (QI) for rectal cancer multidisciplinary cancer conference (MCC).
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Subendran, J., Huang, H., O’Connor, B., Thipphavong, S., Cummings, B., Brierley, J., Jhaveri, K., Kirsch, R., McLeod, R.S., and Kennedy, E.D.
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- 2013
10. Studies on the Anoplura and Mallophaga, being a report upon a collection from the mammals and birds in the Society's Gardens. Part II
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Cummings, B F and BioStor
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- 1916
11. 43 Preoperative cognitive impairment and its impact on postoperative delirium — a pilot study
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Newman, D., Bergman, S., Cummings, B.-A., Delisle, M., Whitehead, V., and Chertkow, H.
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- 2011
12. The Legacy of Exile and the Rise of Humanitarianism
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Janssen, G.H., Cummings, B., Law, C., Riley, K., Walsham, A., and ASH (FGw)
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The Reformation is said to have sparked the first ‘refugee crisis’ in European history. This essay seeks to map and compare memories of flight and displacement among different confessional groups. More specifically, it shows how histories of forced migration gave rise to a cult of exile which became a popular tool of religious expression in post-Reformation Europe. The cultivation of the exile experience was furthered in particular by transnational solidarity networks that had emerged during the sixteenth century. By organising charity campaigns, shaping media coverage and lobbying for refugee protection, these competing confessional pressure groups encouraged the development of a humanitarian culture on which the eighteenth-century Enlightenment would build.
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- 2020
13. Remembering the Holy League. Material Memories in Early Modern France
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Cummings, B., Law, C., Riley, K., Walsham, A., Linden, D.C. van der, Cummings, B., Law, C., Riley, K., Walsham, A., and Linden, D.C. van der
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Item does not contain fulltext
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- 2020
14. The Inheritance of Loss: Post-Reformation Memory Culture and the Limits of Antiquarian Discourse
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Cummings, Brian, Law, Ceri, Wallace, Bronwyn, Walsham, Alexandra, Cummings, B ( Brian ), Law, C ( Ceri ), Wallace, B ( Bronwyn ), Walsham, A ( Alexandra ), Karremann, Isabel, Cummings, Brian, Law, Ceri, Wallace, Bronwyn, Walsham, Alexandra, Cummings, B ( Brian ), Law, C ( Ceri ), Wallace, B ( Bronwyn ), Walsham, A ( Alexandra ), and Karremann, Isabel
- Abstract
This essay explores the impact of the Reformation on the structures of early modern memory culture. Starting from recent historiographical revisions of post-Reformation practices of commemoration, it examines the interplay of remembering and forgetting in antiquarian scholarship — a discourse which confronted directly the problems posed by the destruction of material and ritual means for commemoration. While antiquarian discourse in particular conceived of its project in terms of salvaging the material objects of England’s past from the grave of oblivion, some scholars developed complex notions of the constructive role forgetting might play in a larger, transcendental vision of immortality. Reading Browne’s Hydriotaphia, or Urne-Buriall (1658) against the background of antiquarian texts like Camden’s Britannia (1596; 1610), Stow’s Survey of London (1603), and Weever’s Ancient Funerall Monuments (1631) the essay charts the different strategies developed to come to terms with the painful memories of the Reformation, which constitute the thematic concern of these texts, as well as memory culture profoundly shaped by the forces of oblivion.
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- 2020
15. Congenital titinopathy: comprehensive characterisation & pathogenic insights
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Oates, E, Jones, K, Donkervoort, S, Charlton, A, Brammah, S, Smith, J, Ware, J, Yau, K, Swanson, L, Whiffin, N, Peduto, A, Bournazos, A, Waddell, L, Farrar, M, Sampaio, H, Teoh, H, Lamont, P, Mowat, D, Fitzsimmons, R, Corbett, A, Ryan, M, O'Grady, G, Sandaradura, S, Ghaoui, R, Joshi, H, Marshall, J, Nolan, M, Kaur, S, Punetha, J, Topf, A, Harris, E, Bakshi, M, Genetti, C, Marttila, M, Werkauff, U, Streichenberger, N, Pestronk, A, Mazanti, I, Pinner, J, Vuillerot, C, Grosmann, C, Camacho, A, Mohassel, P, Leach, M, Foley, A, Bharucha-Goeber, D, Collins, J, Connolly, A, Gilbreath, H, Iannaccone, S, Castro, D, Cummings, B, Webster, R, Lazaro, L, Vissing, J, Coppens, S, Deconinck, N, Luk, H, Thomas, N, Foulds, N, Illingworth, M, Ellard, S, McLean, C, Phadke, R, Ravenscroft, G, Witting, N, Hackman, P, Clarke, N, Lek, M, Beggs, A, Bonnemann, C, MacArthur, D, Granzier, H, Davis, M, Laing, N, Oates, E, Jones, K, Donkervoort, S, Charlton, A, Brammah, S, Smith, J, Ware, J, Yau, K, Swanson, L, Whiffin, N, Peduto, A, Bournazos, A, Waddell, L, Farrar, M, Sampaio, H, Teoh, H, Lamont, P, Mowat, D, Fitzsimmons, R, Corbett, A, Ryan, M, O'Grady, G, Sandaradura, S, Ghaoui, R, Joshi, H, Marshall, J, Nolan, M, Kaur, S, Punetha, J, Topf, A, Harris, E, Bakshi, M, Genetti, C, Marttila, M, Werkauff, U, Streichenberger, N, Pestronk, A, Mazanti, I, Pinner, J, Vuillerot, C, Grosmann, C, Camacho, A, Mohassel, P, Leach, M, Foley, A, Bharucha-Goeber, D, Collins, J, Connolly, A, Gilbreath, H, Iannaccone, S, Castro, D, Cummings, B, Webster, R, Lazaro, L, Vissing, J, Coppens, S, Deconinck, N, Luk, H, Thomas, N, Foulds, N, Illingworth, M, Ellard, S, McLean, C, Phadke, R, Ravenscroft, G, Witting, N, Hackman, P, Clarke, N, Lek, M, Beggs, A, Bonnemann, C, MacArthur, D, Granzier, H, Davis, M, and Laing, N
- Published
- 2018
16. Applications of infrared laser spectroscopy to breath analysis
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Cummings, B and Hancock, G
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Chemistry & allied sciences - Abstract
The work presented in this thesis is concerned with development of spectroscopic detection methods based on absorption spectroscopy using semiconductor lasers, with particular ref- erence to the field of medical diagnostics through breath analysis. The first part of this thesis deals with the design and testing of a prototype analyser for simultaneous monitoring of the exchange gases O2 , CO2 and H2O in breath. The aim of this analyser is to provide information required to monitor respiration, with potential use in intensive care monitoring or during anaesthesia. The relatively high concentrations of these gases in breath and read- ily available diode laser sources make detection in the near-infrared (NIR) ideal. However, the relatively weakly absorbing A-band O2 transitions at 760 nm require the application of a sensitive spectroscopic method, cavity enhanced absorption spectroscopy (CEAS). In contrast, CO2 and H2O are monitored using direct single pass absorption spectroscopy, with transitions arising from the 2ν1 + ν3 band at 2 μm and ν1 + ν3 band at 1.3 μm, respectively. It has been demonstrated that these gases can be detected simultaneously over a short pathlength (2.74 - 4 cm) in the respiratory flow by combining various spectroscopic methodologies and real-time data analysis. This analyser is shown to offer a viable alter- native for monitoring respiration, exhibiting absolute detection limits of changes of 0.26 % O2 , 0.02 % CO2 and 0.003 % H2O with a 10 ms time resolution, which are comparable to current mass spectrometry based methods, but without their inherent delays. Following this, investigations into the detection of the main gas constituents in breath in the NIR employing noise-reduction modulation based spectroscopic techniques, namely wavelength and frequency modulation (WMS and FMS respectively) are also reported. The described WMS studies on water at 1.37 μm provide a demonstration of conventional WMS detection, as well as a “proof-of-principle” example of a relatively new approach to calibrating the non-absolute information obtained from a WMS absorption signal. Typically WMS spectra are calibrated using mixtures of known gas concentrations or an absolute direct absorption spectrum where possible. In this work however, a self-calibrating method, the phasor decomposition method (PDM), is employed and the returned concentration from this calibration is compared to direct absorption measurement. From this, the calculated concentration using the PDM is found to differ by 9 % from the concentration value obtained by direct absorption, providing an alternative method of calibration for when direct absorption measurements are not possible. The use of FMS in the NIR is also demonstrated as a potential alternative to CEAS for monitoring O2 at 760 nm. FMS detection is performed on atmospherically broadened O2 and a time-normalised αmin(t) of 2.45 ×10−6 cm−1 s1/2 is obtained, which is two orders of magnitude less sensitive than the value of αmin(t) = 2.35 ×10−8 cm−1 s1/2 obtained with CEAS. This combined with the experimental requirements of an FMS system, make its use for detection of O2 a less practicable option compared to CEAS for real-time breath analysis. The latter work in this thesis involves a change in focus to detection of trace gases in breath in the mid-infrared (MIR). The move of spectroscopic detection to the MIR exploits the larger absorption cross-sections available in this region, and to achieve this, a relatively new form of semiconductor laser, the quantum cascade laser (QCL) is used. The design of a continuous wave QCL spectrometer at 8 μm and its operating characteristics are demon- strated and improvements in its performances are also discussed. This QCL system is then utilised to demonstrate the potential of monitoring species in breath, namely the narrow- band absorber methane and the broadband absorber acetone, taking into consideration the potential interference from other absorbing species in breath and the different spectroscopic characteristics exhibited by these molecules. Finally, the potential to further improve the sensitive detection of trace gases in breath in the MIR is also investigated with studies on the use of CEAS and multipass cells. In this work, the molecule of interest is the biomarker OCS, using transitions of the 2ν2 band at 1031 cm−1 , that are probed using a 10 μm QCL. The application of CEAS in the MIR is not as well developed as in the NIR, and the experimental consequences of using optical cavities at these wavelengths, where equipment tends to be more limited, are investigated and sensitivities discussed in the context of other literature. The experimental procedure of optimising a cavity for CEAS using the off-axis alignment method is also studied in detail, as well as the addition of WMS to further improve the signal quality. An effective absorption pathlength of ∼ 100 m was achieved in the cavity, with a bandwidth reduced αmin(BW) of 1.7 ×10−7 cm−1 Hz−1/2 using WMS CEAS achieved. With the poorer quality optics and limitations in equipment in the MIR for CEAS experiments, the use of a multipass cell, a 238 m Herriott cell, is also investigated as an alternative to the use of an optical cavity at 10 μm. Detection of OCS using direct absorption and WMS is demonstrated in the Herriott cell, achieving αmin(BW) = 2.03×10−8 cm−1 Hz−1/2 using WMS. This shows an improvement in sensitivity compared to WMS CEAS, and also shows the potential for future work on biomarker detection, as it approaches the ∼ ppb levels required for breath analysis.
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- 2016
17. A common dominant-negative COL6A1 pseudo-exon insertion is skippable using splice-modulating oligonucleotides
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Bolduc, V., Foley, A., Donkervoort, S., Hu, Y., Cummings, B., Lek, M., Sarathy, A., Sizov, K., Degefa, H., Wagener, R., Hennig, G., Hanssen, E., Lamande, S., Muntoni, F., Wilton, S., MacArthur, D., Bonnemann, C., Bolduc, V., Foley, A., Donkervoort, S., Hu, Y., Cummings, B., Lek, M., Sarathy, A., Sizov, K., Degefa, H., Wagener, R., Hennig, G., Hanssen, E., Lamande, S., Muntoni, F., Wilton, S., MacArthur, D., and Bonnemann, C.
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- 2017
18. A typology of longitudinal integrated clerkships.
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Worley, P, Couper, I, Strasser, R, Graves, L, Cummings, B-A, Woodman, R, Stagg, P, Hirsh, D, Consortium of Longitudinal Integrated Clerkships (CLIC) Research Collaborative, Worley, P, Couper, I, Strasser, R, Graves, L, Cummings, B-A, Woodman, R, Stagg, P, Hirsh, D, and Consortium of Longitudinal Integrated Clerkships (CLIC) Research Collaborative
- Abstract
CONTEXT: Longitudinal integrated clerkships (LICs) represent a model of the structural redesign of clinical education that is growing in the USA, Canada, Australia and South Africa. By contrast with time-limited traditional block rotations, medical students in LICs provide comprehensive care of patients and populations in continuing learning relationships over time and across disciplines and venues. The evidence base for LICs reveals transformational professional and workforce outcomes derived from a number of small institution-specific studies. OBJECTIVES: This study is the first from an international collaborative formed to study the processes and outcomes of LICs across multiple institutions in different countries. It aims to establish a baseline reference typology to inform further research in this field. METHODS: Data on all LIC and LIC-like programmes known to the members of the international Consortium of Longitudinal Integrated Clerkships were collected using a survey tool developed through a Delphi process and subsequently analysed. Data were collected from 54 programmes, 44 medical schools, seven countries and over 15 000 student-years of LIC-like curricula. RESULTS: Wide variation in programme length, student numbers, health care settings and principal supervision was found. Three distinct typological programme clusters were identified and named according to programme length and discipline coverage: Comprehensive LICs; Blended LICs, and LIC-like Amalgamative Clerkships. Two major approaches emerged in terms of the sizes of communities and types of clinical supervision. These referred to programmes based in smaller communities with mainly family physicians or general practitioners as clinical supervisors, and those in more urban settings in which subspecialists were more prevalent. CONCLUSIONS: Three distinct LIC clusters are classified. These provide a foundational reference point for future studies on the processes and outcomes of LICs. The study also ex
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- 2016
19. Treatment of primary epidermoid carcinoma of the anal canal
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Cummings, B. J.
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- 1987
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20. Cyclin-Dependent Kinase Inhibitor 1a (p21) Modulates Response to Cocaine and Motivated Behaviors
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Scholpa, N. E., primary, Briggs, S. B., additional, Wagner, J. J., additional, and Cummings, B. S., additional
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- 2016
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21. Pediatric Extubation Readiness: Faith-Based Practice or Amenable to Standardization?
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Cummings, B. M., primary and Noviski, N., additional
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- 2014
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22. Autorotica
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Cummings, B.
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Holiday Review - Published
- 1998
23. Prescription for Wealth: Financial Planning for the Health Care Professional
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Cummings, B E
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Books and Other Media - Published
- 1997
24. Bax Regulates Production of Superoxide in Both Apoptotic and Nonapoptotic Neurons: Role of Caspases
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Kirkland, R. A., primary, Saavedra, G. M., additional, Cummings, B. S., additional, and Franklin, J. L., additional
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- 2010
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25. Adjuvant Chemoradiation for Gastric Cancer with Infusional 5-Fluorouracil and Cisplatin: A Phase I Study
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Kassam, Zahra, primary, MacKay, H., additional, Buckley, C. A., additional, Fung, S., additional, Pintile, M., additional, Oza, A., additional, Brierley, J., additional, Swallow, C., additional, Cummings, B., additional, Knox, J. J., additional, Kim, J., additional, Wong, R., additional, Siu, L., additional, Feld, R., additional, and Ringash, J., additional
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- 2010
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26. Shedding of salmonella by flocks of wild birds in coastal, estuarine and freshwater river environments.
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Cummings, B., Jones, Keith, Cummings, B., and Jones, Keith
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- 2002
27. Effect of a synthetic pyrethroid-based sheep dip on protozoa predating faecal coliforms and salmonellae in farm slurries.
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Owen, D., Brown, J., Cummings, B., Semple, Kirk T., Jones, Keith, Owen, D., Brown, J., Cummings, B., Semple, Kirk T., and Jones, Keith
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- 2002
28. The Truths and Myths of Radiotherapy for Verrucous Carcinoma of Larynx
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Huang, S., primary, Lockwood, G., additional, Irish, J., additional, Ringash, J., additional, Kim, J., additional, Waldron, J., additional, Dawson, L., additional, Bayley, A., additional, Cummings, B., additional, and O'Sullivan, B., additional
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- 2007
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29. Probabilistic Analysis of Cord Position in Daily On-Line Cone Beam CT Imaging for Head and Neck Radiotherapy
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Breen, S.L., primary, Thomas, C., additional, Vakilha, M., additional, Bayley, A., additional, Dawson, L., additional, Cummings, B., additional, Kim, J., additional, Ringash, J., additional, O'Sullivan, B., additional, and Waldron, J., additional
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- 2007
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30. Temporo-spatial Changes of Enlarged Cervical Lymph Nodes During Head and Neck Cancer IMRT Imaged With Daily On-Line Cone-Beam CT
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Hwang, D., primary, Vakilha, M., additional, Breen, S., additional, Thomas, C., additional, Dawson, L., additional, Ringash, J., additional, Kim, J., additional, Cummings, B., additional, O'Sullivan, B., additional, and Waldron, J., additional
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- 2007
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31. Randomized Trial of Cone Beam CT Evaluating Inter- and Intra-Fraction Setup Error of Head and Neck Cancer Patients Treated With a Skin-Sparing Mask Compared to a Standard S-Frame Mask
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Velec, M., primary, Hwang, D., additional, Waldron, J.N., additional, O'Sullivan, B., additional, Bayley, A., additional, Cummings, B., additional, Kim, J.J., additional, Ringash, J., additional, Breen, S.L., additional, and Dawson, L.A., additional
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- 2007
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32. The Effect of Registration Volumes on Positional Residual Errors Assessed Using Cone-Beam Computed Tomography in Radiation Treatment of Head and Neck Cancer
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Johnson, L., primary, Waldron, J., additional, Dawson, L., additional, Bayley, A., additional, Cummings, B., additional, Kim, J., additional, O'Sullivan, B., additional, Ringash, J., additional, and Breen, S.L., additional
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- 2007
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33. Changes in Position and Size of Parotid Glands Assessed With Daily Cone-Beam CT During Image-Guided IMRT for Head and Neck Cancer: Implications for Dose Received
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Vakilha, M., primary, Hwang, D., additional, Breen, S.L., additional, Dawson, L.A., additional, Ringash, J., additional, Bayley, A., additional, Kim, J., additional, Cummings, B., additional, O'Sullivan, B., additional, and Waldron, J., additional
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- 2007
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34. Waiting
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Cummings, B.-A., primary
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- 2007
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35. 2413
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De Silva, S.L., primary, Waldron, J.N., additional, Breen, S., additional, Brock, K., additional, Pond, G., additional, Cummings, B., additional, Dawson, L., additional, Kim, J., additional, Ringash, J., additional, and O Sullivan, B., additional
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- 2006
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36. 1072
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Dawson, L.A., primary, Hawkins, M., additional, Eccles, C.M., additional, Bissonnette, J., additional, Lockwood, G., additional, Kim, J., additional, Cummings, B., additional, Sherman, M., additional, Knox, J., additional, and Gallinger, S., additional
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- 2006
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37. 4 Main
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Cummings, B.-A., primary
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- 2005
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38. A Phase II Study of Preoperative Conformal Radiotherapy and Chemotherapy (CPTII/Cisplatin) for Esophageal Cancer
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Wong, R., primary, Ringash, J., additional, Kim, J., additional, Cummings, B., additional, Knox, J., additional, Darling, G., additional, Haider, M., additional, Guindi, M., additional, Cheung, F., additional, Hornby, J., additional, and Brierley, J., additional
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- 2005
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39. Major Salivary Gland Function: Diffusion-weighted MRI (DWI) Assessment Before, During and After Radiation Therapy
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Studer, G., primary, Kirilova, A., additional, Jaffray, D., additional, Dawson, L., additional, Lockwood, G., additional, Bayley, A., additional, Cummings, B., additional, Kim, J., additional, Ringash, J., additional, Waldron, J., additional, and O’Sullivan, B., additional
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- 2005
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40. High Dose Cisplatin and Conformal Radiation for Cervical Esophageal Cancer
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Huang, S., primary, Ringash, J., additional, Lockwood, G., additional, Cummings, B., additional, Wong, R., additional, Kim, J., additional, Catton, P., additional, Saporta, A., additional, and Brierley, J., additional
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- 2005
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41. Analysis of Gross Target Volume (GTV) Observer Variability with FDG-PET and Contrast Enhanced CT in Head and Neck Cancer Using Finite Element Modeling
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De Silva, S., primary, Waldron, J., additional, Breen, S., additional, Brock, K., additional, Pond, G., additional, Cummings, B., additional, Dawson, L., additional, Keller, A., additional, Kim, J., additional, Ringash, J., additional, Yu, E., additional, and Sullivan, B.O., additional
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- 2005
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42. Toxicity, Survival and Predictors of Outcome in Patients Receiving Adjuvant Chemoradiation for Gastric Adenocarcinoma
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Ringash, J., primary, Kassam, Z., additional, Oza, A., additional, Swallow, C., additional, O’Brien, C., additional, Lockwood, G., additional, Moore, M., additional, Siu, L., additional, Knox, J.J., additional, Wong, R., additional, Cummings, B., additional, and Brierley, J., additional
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- 2005
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43. SEMANTIC BIOLOGICAL IMAGE MANAGEMENT AND ANALYSIS
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CHUBB, CHARLIE, primary, INAGAKI, YOSHI, additional, COTMAN, C., additional, CUMMINGS, B., additional, and SHEU, P. C.-Y., additional
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- 2004
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44. Early volumetric changes in major salivary glands (MSG) after curative radiation therapy (RT) in head and neck cancer patients
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STUDER, G, primary, JAFFRAY, D, additional, WILKE, D, additional, BAYLEY, A, additional, CUMMINGS, B, additional, KIM, J, additional, RINGASH, J, additional, WALDRON, J, additional, and OSULLIVAN, B, additional
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- 2004
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45. Preoperative radiation with concurrent chemotherapy for resectable rectal cancer: Effect of dose escalation on pathological complete response, local recurrence free survival &disease free survival
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Wiltshire, K., primary, Brierley, J., additional, Swallow, C., additional, Oza, A., additional, Cummings, B., additional, Catton, P., additional, Kim, J., additional, Ringash, J., additional, Wong, R., additional, Siu, L., additional, Pond, G., additional, and Moore, M., additional
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- 2004
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46. Primary radical external beam radiotherapy of rectal adenocarcinoma: Long term outcome of 271 patients
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WANG, Y, primary, BRIERLEY, J, additional, CUMMINGS, B, additional, DAWSON, L, additional, KIM, J, additional, RINGASH, J, additional, WONG, R, additional, YI, Q, additional, and CATTON, P, additional
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- 2004
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47. IMRT for adjuvant radiation in gastric cancer: a preferred plan?
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Ringash, J, primary, Perkins, G, additional, Lockwood, G, additional, Brierley, J, additional, Kim, J, additional, Wong, R, additional, Cummings, B, additional, and Catton, P, additional
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- 2003
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48. Distribution of Protease-resistant Prion Protein and Spongiform Encephalopathy in Free-ranging Mule Deer (Odocoileus hemionus) with Chronic Wasting Disease
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Spraker, T. R., primary, Zink, R. R., additional, Cummings, B. A., additional, Sigurdson, C. J., additional, Miller, M. W., additional, and O'Rourle, K. I., additional
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- 2002
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49. Comparison of Histological Lesions and Immunohistochemical Staining of Proteinase-resistant Prion Protein in a Naturally Occurring Spongiform Encephalopathy of Free-ranging Mule Deer (Odocoileus hemionus) with Those of Chronic Wasting Disease of Captive Mule Deer
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Spraker, T. R., primary, Zink, R. R., additional, Cummings, B. A., additional, Wild, M. A., additional, Miller, M. W., additional, and O'Rourke, K. I., additional
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- 2002
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50. Validation of Monoclonal Antibody F99/97.6.1 for Immunohistochemical Staining of Brain and Tonsil in Mule Deer (Odocoileus Hemionus) with Chronic Wasting Disease
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Spraker, T. R., primary, O'Rourke, K. I., additional, Balachandran, A., additional, Zink, R. R., additional, Cummings, B. A., additional, Miller, M. W., additional, and Powers, B. E., additional
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- 2002
- Full Text
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