Search

Imperfections in analog-to-digital conversion (ADC) cannot be ignored when signal digitization requirements demand both wide dynamic range and high resolution, as is the case for the Majorana Demonstrator 76Ge neutrinoless double-beta decay search. Enabling the experiment’s high-resolution spectral analysis and efficient pulse shape discrimination required careful measurement and correction of ADC nonlinearities. A simple measurement protocol was developed that did not require sophisticated equipment or lengthy data-taking campaigns. A slope-dependent hysteresis was observed and characterized. A correction applied to digitized waveforms prior to signal processing reduced the differential and integral nonlinearities by an order of magnitude, eliminating these as dominant contributions to the systematic energy uncertainty at the double-beta decay $Q$ value.

Background: Previous studies have reported that acupuncture combined Bobath approach (BA) can be used to treat limbs paralysis (LP) after hypertensive intracerebral hemorrhage (HICH) effectively. However, no systematic review has explored its effectiveness and safety for LP following HICH. In this systematic review, we aim to assess the effectiveness and safety of acupuncture plus BA for the treatment of LP following HICH. Methods: The following 7 databases will be searched from their inception to the February 1, 2019: Cochrane Central Register of Controlled Trials, EMBASE, PUBMED, the Cumulative Index to Nursing and Allied Health Literature, the Allied and Complementary Medicine Database, Chinese Biomedical Literature Database, and China National Knowledge Infrastructure without any language restrictions. The randomized controlled trials (RCTs) of acupuncture plus BA that evaluate the effectiveness and safety for LP after HICH will be included. The methodological quality of all included studies will be assessed by using Cochrane risk of bias tool. Two authors will independently perform study selection, data extraction, and methodological quality evaluation. Any disagreements occurred between 2 authors will be resolved by a third author involved through discussion. Data will be pooled and analyzed by using RevMan 5.3 Software. Results: This review will evaluate the effectiveness and safety of acupuncture combined BA for LP following HICH. The primary outcome is limbs function. The secondary outcomes are muscle strength, muscle tone, and quality of life, as well as the adverse events. Conclusion: The results of this study will summarize the latest evidence of acupuncture combined BA for LP following HICH.

Author(s): Haufe, CR; Reine, AL; Abgrall, N; Alvis, SI; Arnquist, IJ; Avignone, FT; Barabash, AS; Barton, CJ; Bertrand, FE; Bode, T; Bradley, AW; Brudanin, V; Busch, M; Buuck, M; Caldwell, TS; Chan, YD; Christofferson, CD; Chu, PH; Cuesta, C; Detwiler, JA; Dunagan, C; Efremenko, Y; Ejiri, H; Elliott, SR; Gilliss, T; Giovanetti, GK; Green, MP; Gruszko, J; Guinn, IS; Guiseppe, VE; Hehn, L; Henning, R; Hoppe, EW; Howe, MA; Keeter, KJ; Kidd, MF; Konovalov, SI; Kouzes, RT; Lopez, AM; Martin, RD; Massarczyk, R; Meijer, SJ; Mertens, S; Myslik, J; O'Shaughnessy, C; Othman, G; Pettus, W; Poon, AWP; Radford, DC; Rager, J; Rielage, K; Robertson, RGH; Ruof, NW; Shanks, B; Shirchenko, M; Suriano, AM; Tedeschi, D; Trimble, JE; Varner, RL; Vasilyev, S; Vetter, K; Vorren, K; White, BR; Wilkerson, JF; Wiseman, C; Xu, W; Yakushev, E; Yu, CH; Yumatov, V; Zhitnikov, I; Zhu, BX | Abstract: The MAJORANA DEMONSTRATOR is an experiment constructed to search for neutrinoless double-beta decays in germanium-76 and to demonstrate the feasibility to deploy a ton-scale experiment in a phased and modular fashion. It consists of two modular arrays of natural and 76Ge-enriched germanium p-Type point contact detectors totaling 44.1 kg, located at the 4850' level of the Sanford Underground Research Facility in Lead, South Dakota, USA. The DEMONSTRATOR uses custom high voltage cables to bias the detectors, as well as custom signal cables and connectors to read out the charge deposited at each detectors point contact. These low-mass cables and connectors must meet stringent radiopurity requirements while being subjected to thermal and mechanical stress. A number of issues have been identified with the currently installed cables and connectors. An improved set of cables and connectors for the MAJORANA DEMONSTRATOR are being developed with the aim of increasing their overall reliability and connectivity. We will discuss some of the issues encountered with the current cables and connectors as well as our improved designs and their initial performance.

The MAJORANA DEMONSTRATOR is an experiment constructed to search for neutrinoless double-beta decay in $^{76}$Ge and to demonstrate the feasibility to deploy a large-scale experiment in a phased and modular fashion. It consists of two modules of natural and $^{76}$Ge-enriched germanium detectors totalling 44.1 kg, operating at the 4850' level of the Sanford Underground Research Facility in Lead, South Dakota, USA. Commissioning of the experiment began in June 2015, followed by data production with the full detector array in August 2016. The ultra-low background and record energy resolution achieved by the MAJORANA DEMONSTRATOR enable a sensitive neutrinoless double-beta decay search, as well as additional searches for physics beyond the Standard Model. I will discuss the design elements that enable these searches, along with the latest results, focusing on the neutrinoless double-beta decay search. I will also discuss the current status and the future plans of the MAJORANA DEMONSTRATOR, as well as the plans for a future tonne-scale $^{76}$Ge experiment., 4 pages. Proceedings of The 39th International Conference on High Energy Physics (ICHEP2018), 4-11 July, 2018, Seoul, Korea. Submitted to Proceedings of Science

The MAJORANA Collaboration is searching for the neutrinoless double-beta decay of the nucleus Ge-76. The MAJORANA DEMONSTRATOR is an array of germanium detectors deployed with the aim of implementing background reduction techniques suitable for a tonne scale Ge-76-based search (the LEGEND collaboration). In the DEMONSTRATOR, germanium detectors operate in an ultra-pure vacuum cryostat at 80 K. One special challenge of an ultra-pure environment is to develop reliable cables, connectors, and electronics that do not significantly contribute to the radioactive background of the experiment. This paper highlights the experimental requirements and how these requirements were met for the MAJORANA DEMONSTRATOR, including plans to upgrade the wiring for higher reliability in the summer of 2018. Also described are requirements for LEGEND R&D efforts underway to meet these additional requirements., Proceedings of LRT 2017

Myeloid differentiation factor 88 (MyD88) is an adapter protein involved in the interleukin-1 receptor (IL-1R) and Toll-like receptor (TLR)-mediated activation of nuclear factor-kappaB (NF-κB). In this study, a full length cDNA of MyD88 was cloned from turbot, Scophthalmus maximus. It is 1619 bp in length and contains an 858-bp open reading frame that encodes a peptide of 285 amino acid residues. The putative turbot (Sm)MyD88 protein possesses a N-terminal death domain and a C-terminal Toll/IL-1 receptor (TIR) domain known to be important for the functions of MyD88 in mammals. Phylogenetic analysis grouped SmMyD88 with other fish MyD88s. SmMyD88 mRNA was ubiquitously expressed in all examined tissues of healthy turbots, with higher levels observed in immune-relevant organs. To explore the role of SmMyD88, its gene expression profile in response to stimulation of lipopolysaccharide (LPS), CpG oligodeoxynucleotide (CpG-ODN) or turbot reddish body iridovirus (TRBIV) was studied in the head kidney, spleen, gills and muscle over a 7-day time course. The results showed an up-regulation of SmMyD88 transcript levels by the three immunostimulants in all four examined tissues, with the induction by CpG-ODN strongest and initiated earliest and inducibility in the muscle very weak. Additionally, TRBIV challenge resulted in a quite high level of SmMyD88 expression in the spleen, whereas the two synthetic immunostimulants induced the higher levels in the head kidney. These data provide insights into the roles of SmMyD88 in the TLR/IL-1R signaling pathway of the innate immune system in turbot.

High purity germanium (HPGe) crystals will be used for the MAJORANA DEMONSTRATOR, where they serve as both the source and the detector for neutrinoless double beta decay. It is crucial for the experiment to understand the performance of the HPGe crystals. A variety of crystal properties are being investigated, including basic properties such as energy resolution, efficiency, uniformity, capacitance, leakage current and crystal axis orientation, as well as more sophisticated properties, e.g. pulse shapes and dead layer and transition layer distributions. In this paper, we will present our measurements that characterize the HPGe crystals. We will also discuss our simulation package for the detector characterization setup, and show that additional information can be extracted from data-simulation comparisons., Comment: To appear in the Proceedings of the 13th International Conference on Topics in Astroparticle and Underground Physics, TAUP 2013 (F. Avignone & W. Haxton, editors, Physics Procedia, Elsevier)

Neutrinoless double-beta decay searches play a major role in determining the nature of neutrinos, the existence of a lepton violating process, and the effective Majorana neutrino mass. The MAJORANA Collaboration assembled an array of high purity Ge detectors to search for neutrinoless double-beta decay in Ge-76. The MAJORANA DEMONSTRATOR is comprised of 44.1 kg (29.7 kg enriched in Ge-76) of Ge detectors divided between two modules contained in a low-background shield at the Sanford Underground Research Facility in Lead, South Dakota, USA. The initial goals of the DEMONSTRATOR are to establish the required background and scalability of a Ge-based next-generation ton-scale experiment. Following a commissioning run that started in 2015, the first detector module started low-background data production in early 2016. The second detector module was added in August 2016 to begin operation of the entire array. We discuss results of the initial physics runs, as well as the status and physics reach of the full MAJORANA DEMONSTRATOR experiment., Proceedings of the MEDEX'17 meeting (Prague, May 29 - June 2, 2017)

Electromagnetic properties of atomic nuclei such as $E2$ transition rates and $M1$ magnetic moments (or $g$ factors) are crucial characteristics of structure. For unstable nuclei produced as reaccelerated radioactive beams, measurements of $g$ factors present numerous challenges. This paper develops the important recoil-in-vacuum technique to obtain a $g$ factor for the ${2}^{+}$ state in ${}^{136}$Te. The result fits existing systematics but also highlights anomalous values in other $N=84$ isotones, thus presenting an important challenge to theory in the region just above doubly magic ${}^{132}$Sn.

A search for Pauli-exclusion-principle-violating K-alpha electron transitions was performed using 89.5 kg-d of data collected with a p-type point contact high-purity germanium detector operated at the Kimballton Underground Research Facility. A lower limit on the transition lifetime of 5.8x10^30 seconds at 90% C.L. was set by looking for a peak at 10.6 keV resulting from the x-ray and Auger electrons present following the transition. A similar analysis was done to look for the decay of atomic K-shell electrons into neutrinos, resulting in a lower limit of 6.8x10^30 seconds at 90 C.L. It is estimated that the MAJORANA DEMONSTRATOR, a 44 kg array of p-type point contact detectors that will search for the neutrinoless double-beta decay of 76-Ge, could improve upon these exclusion limits by an order of magnitude after three years of operation. Abgrall, N; Arnquist, I J; Avignone, F T; Barabash, A S; Bertrand, F E; Bradley, A W; Brudanin, V; Busch, M; Buuck, M; Caldwell, A S; Chan, Y-D; Christofferson, C D; Chu, P -H; Cuesta, C; Detwiler, J A; Dunagan, C; Efremenko, Yu; Ejiri, H; Elliott, S R; Finnerty, P S; Galindo-Uribarri, A; Gilliss, T; Giovanetti, G K; Goett, J; Green, M P; Gruszko, J; Guinn, I S; Guiseppe, V E; Henning, R; Hoppe, E W; Howard, S; Howe, M A; Jasinski, B R; Keeter, K J; Kidd, M F; Konovalov, S I; Kouzes, R T; LaFerriere, B D; Leon, J; MacMullin, J; Martin, R D; Massarczyk, R; Meijer, S J; Mertens, S; Orrell, J L; O'Shaughnessy, C; Poon, A W P; Radford, D C; Rager, J; Rielage, K; Robertson, R G H; Romero-Romero, E; Shanks, B; Shirchenko, M; Suriano, A M; Tedeschi, D; Trimble, J E; Varner, R L; Vasilyev, S; Vetter, K; Vorren, K; White, B R; Wilkerson, J F; Wiseman, C; Xu, W; Yakushev, E; Yu, C -H; Yumatov, V; Zhitnikov, I

The MAJORANA Collaboration is building the MAJORANA DEMONSTRATOR, a 60 kg array of high purity germanium detectors housed in an ultra-low background shield at the Sanford Underground Laboratory in Lead, SD. The MAJORANA DEMONSTRATOR will search for neutrinoless double-beta decay of 76Ge while demonstrating the feasibility of a tonne-scale experiment. It may also carry out a dark matter search in the 1-10 GeV/c^2 mass range. We have found that customized Broad Energy Germanium (BEGe) detectors produced by Canberra have several desirable features for a neutrinoless double-beta decay experiment, including low electronic noise, excellent pulse shape analysis capabilities, and simple fabrication. We have deployed a customized BEGe, the MAJORANA Low-Background BEGe at Kimballton (MALBEK), in a low-background cryostat and shield at the Kimballton Underground Research Facility in Virginia. This paper will focus on the detector characteristics and measurements that can be performed with such a radiation detector in a low-background environment., Comment: Submitted to NIMA Proceedings, SORMA XII. 9 pages, 4 figures

A complete set of electromagnetic moments, B(E2;0+1 2+1), Q(2+1), and g(2+1), have been measured from Coulomb excitation of semi-magic 112,114,116,118,120,122,124Sn (Z = 50) on natural carbon and titanium targets. The magnitude of the B(E2) values, measured to a precision of ~4%, disagree with a recent lifetime study [Phys. Lett. B 695, 110 (2011)] that employed the Doppler- shift attenuation method. The B(E2) values show an overall enhancement compared with recent theoretical calculations and a clear asymmetry about midshell, contrary to naive expectations. A new static electric quadrupole moment, Q(2+1), has been measured for 114Sn. The static quadrupole moments are generally consistent with zero but reveal an enhancement near midshell; this had not been previously observed. The magnetic dipole moments are consistent with previous measurements and show a near monotonic decrease in value with neutron number. The current theory calculations fail to reproduce the electromagnetic moments of the tin isotopes. The role of 2p-2h and 4p-4h intruders, which are lowest in energy at mid shell and outside of current model spaces, needs to be investigated in the future.

The MAJORANA Collaboration is constructing the MAJORANA DEMONSTRATOR, an ultra-low background, modular, HPGe detector array with a mass of 44-kg (29 kg 76Ge and 15 kg natGe) to search for neutrinoless double beta decay in Ge-76. The next generation of tonne-scale Ge-based neutrinoless double beta decay searches will probe the neutrino mass scale in the inverted-hierarchy region. The MAJORANA DEMONSTRATOR is envisioned to demonstrate a path forward to achieve a background rate at or below 1 count/tonne/year in the 4 keV region of interest around the Q-value of 2039 keV. The MAJORANA DEMONSTRATOR follows a modular implementation to be easily scalable to the next generation experiment. First, the prototype module was assembled; it has been continuously taking data from July 2014 to June 2015. Second, Module 1 with more than half of the total enriched detectors and some natural detectors has been assembled and it is being commissioned. Finally, the assembly of Module 2, which will complete MAJORANA DEMONSTRATOR, is already in progress., Comment: 4 pages, 3 figures

The MAJORANA Collaboration is constructing the MAJORANA DEMONSTRATOR, an ultra-low background, 40-kg modular HPGe detector array to search for neutrinoless double beta decay in 76Ge. In view of the next generation of tonne-scale Ge-based 0nbb-decay searches that will probe the neutrino mass scale in the inverted-hierarchy region, a major goal of the MAJORANA DEMONSTRATOR is to demonstrate a path forward to achieving a background rate at or below 1 count/tonne/year in the 4 keV region of interest around the Q-value at 2039 keV. The background rejection techniques to be applied to the data include cuts based on data reduction, pulse shape analysis, event coincidences, and time correlations. The Point Contact design of the DEMONSTRATOR 0s germanium detectors allows for significant reduction of gamma background., 4 pages, 2 figures

High-precision reduced electric-quadrupole transition probabilities $B(E2;{0}_{1}^{+}\ensuremath{\rightarrow}{2}_{1}^{+})$ have been measured from single-step Coulomb excitation of semi-magic $^{58,60,62,64}\mathrm{Ni}$ ($Z=28$) beams at 1.8 MeV per nucleon on a natural carbon target. The energy loss of the nickel beams through the carbon target were directly measured with a zero-degree Bragg detector and the absolute $B(E2)$ values were normalized by Rutherford scattering. The $B(E2)$ values disagree with recent lifetime studies that employed the Doppler-shift attenuation method. The present high-precision $B(E2)$ values reveal an asymmetry about $^{62}\mathrm{Ni}$, midshell between $N=28$ and 40, with larger values towards $^{56}\mathrm{Ni}$ ($Z=N=28$). The experimental $B(E2)$ values are compared with shell-model calculations in the full $pf$ model space and the results indicate a soft $^{56}\mathrm{Ni}$ core.

$\ensuremath{\gamma}$-ray transitions in ${}^{134}\text{Te}$, ${}^{135}\text{Te}$, and ${}^{136}\text{Te}$ were measured from ${}^{9}\text{Be}$-induced reactions with a radioactive ${}^{132}\text{Sn}$ beam at a sub-Coulomb barrier energy of 3 MeV per nucleon using particle-$\ensuremath{\gamma}$ coincidence spectroscopy. The transitions were selected by gating on alpha-like particles in a CsI detector following a combination of $({}^{9}\text{Be},\ensuremath{\alpha}1n)$, $({}^{9}\text{Be},\ensuremath{\alpha}2n)$, and $({}^{9}\text{Be},\ensuremath{\alpha}3n)$ incomplete fusion-evaporation reactions. Distorted-wave Born approximation calculations suggest little to no contribution from the $({}^{9}\text{Be},{}^{7}\text{He})$, $({}^{9}\text{Be},{}^{6}\text{He})$, and $({}^{9}\text{Be},{}^{5}\text{He})$ direct reactions.$\ensuremath{\gamma}$-ray transitions from previously known ${2}^{+}\ensuremath{\bigotimes}\ensuremath{\nu}\phantom{\rule{0.16em}{0ex}}2{f}_{7/2}$ and ${4}^{+}\ensuremath{\bigotimes}\ensuremath{\nu}\phantom{\rule{0.16em}{0ex}}2{f}_{7/2}$ multiplet members in ${}^{135}\text{Te}$ are observed. A new $\ensuremath{\gamma}$ ray is observed, assigned to the third-excited state in ${}^{135}\text{Te}$, and new ${2}^{+}\ensuremath{\bigotimes}\ensuremath{\nu}\phantom{\rule{0.16em}{0ex}}2{f}_{7/2}$ multiplet members are suggested. In addition, spin assignments are made by using recent one-neutron transfer data. The updated experimental data for ${}^{135}\text{Te}$ are compared to shell-model calculations for a relatively complete set of states up to the yrast ${15/2}^{\ensuremath{-}},{4}^{+}\ensuremath{\bigotimes}\ensuremath{\nu}\phantom{\rule{0.16em}{0ex}}2{f}_{7/2}$ multiplet member at 1505 keV.

The MAJORANA DEMONSTRATOR is an array of natural and enriched high purity germanium detectors that will search for the neutrinoless double-beta decay of 76-Ge and perform a search for weakly interacting massive particles (WIMPs) with masses below 10 GeV. As part of the MAJORANA research and development efforts, we have deployed a modified, low-background broad energy germanium detector at the Kimballton Underground Research Facility. With its sub-keV energy threshold, this detector is sensitive to potential non-Standard Model physics, including interactions with WIMPs. We discuss the backgrounds present in the WIMP region of interest and explore the impact of slow surface event contamination when searching for a WIMP signal., Comment: To appear in the Proceedings of the 13th International Conference on Topics in Astroparticle and Underground Physics, TAUP 2013 (F. Avignone & W. Haxton, editors, Physics Procedia, Elsevier)

Two excited well-deformed bands have been observed in the semi-magic nucleus Ni-58. One of the bands was observed to partially decay by emission of a prompt discrete alpha particle that feeds the 2949 keV 6(+) spherical yrast state in the daughter nucleus Fe-54. This constitutes the first observation of prompt alpha emission from states lying in the deformed secondary minimum of the nuclear potential. gamma -ray linking transitions via several parallel paths establish the spin. parity, and excitation energy of this deformed band in Ni-58.

The doubly magic superdeformed band in the N = Z nucleus Zn-60 has been identified. Linking transitions connecting this band to the yrast line provide the first spin, parity, and excitation energy measurements for superdeformed states in the A similar to 60 region. The stretched-E2 character and relatively large B(E2) values of these transitions suggest a nonstatistical decay-out process.

An excited well-deformed rotational band has been observed in the N = Z odd-odd nucleus Cu-58. The first excited state in this band decays via gamma emission to the spherical states associated with the first minimum in the potential, thus providing for its unambiguous assignment to Cu-58. I, contrast, its bandhead decays via emission of a prompt 2.4(1) MeV proton to an excited state in the daughter nucleus Ni-57. This is the first observation of proton decay from states associated with a deformed secondary minimum in the potential. Self-consistent Hartree-Fock calculations reproduce well both the large collectivity of this band and the general trend of its moment of inertia.

Four superdeformed bands are reported in Sr-80, extending known superdeformation in the Sr-38 series down to N = 42. The characteristics of these bands are discussed. Residual Doppler shifts were measured and average transition quadrupole moments (Q(t)) inferred for these new bands, These Q(t) values are compared to Q(t) values obtained for previously identified superdeformed bands in Sr81-83. The low Q(t) of 2.7(-0.6)(+0.7) eb obtained for the yrast band in Sr-80 indicates a reduction in the deformation of yrast superdeformed bands in the series Sr80-83 with decreasing N, and possibly the onset of triaxiality in superdeformed shapes. (C) 1997 Elsevier Science B.V.

The g factors of the first-excited states of stable 124Sn and radioactive 126,128Sn were measured by the recoil in vacuum method with relatively high precision (particularly for 124,126Sn). The experiments were performed at the Holifield Radioactive Ion Beam Facility by Coulomb exciting 3 MeV/u beams in inverse kinematics on carbon and titanium targets. The results for 124Sn and 126Sn are in excellent agreement with recent shell model calculations. For 128Sn the experiment suggests an increase in the magnitude of g(2+1 ), as predicted by some models. The present results provide a sensitive probe of the valence orbitals that contribute to the 2+1 wavefunctions as one approaches the radioactive 132Sn double-shell closure.

Two superdeformed (SD) bands extending over eight to eleven transitions have been identified in Zr-83, The quadrupole moment of the more intense band was determined by the Residual Doppler Shift Method and is consistent with a quadrupole deformation of beta(2) approximate to 0.5. The large quadrupole moment and population intensity of the yrast SD band (approximate to 5%) in Zr isotopes relative to their isotones in Sr and Y nuclei suggest the presence of a large SD shell gap at proton number Z = 40, At the decay-out points, the Routhians of the SD bands reapproach that of the positive parity normally-deformed states which may be the reason why both of these bands feed mainly (approximate to 85%) into the positive-parity yrast band.

The Holifield Radioactive Ion Beam Facility at Oak Ridge National Laboratory has recently produced the world's first post-accelerated beams of heavy neutron-rich nuclei. The first experiments with these beam are described, and the results discussed. B(E2;0+ → 2+) values for neutron-rich 126,128Sn and 132,134,136Te isotopes have been measured by Coulomb excitation in inverse kinematics. The results for 132Te and 134Te (N = 80, 82) show excellent agreement with systematics of lighter Te isotopes, but the B(E2) value for 136Te (N = 84) is unexpectedly small. Single-neutron transfer reactions with a 134Te beam on natBe and 13C targets at energies just above the Coulomb barrier have also been studied.

The ${2}_{2}^{+}$ state in ${}^{132}$Te is identified as the one-phonon mixed-symmetry state in a projectile Coulomb excitation experiment presenting a firm example of a mixed-symmetry state in unstable, neutron-rich nuclei. The results of shell-model calculations based on the low-momentum interaction ${V}_{\mathrm{low}\ensuremath{-}k}$ are in good agreement with experiment demonstrating the ability of the effective shell-model interaction to produce states of mixed-symmetry character.

High-precision measurements of $\ensuremath{\langle}{0}_{1}||M(E2)||{2}_{1}\ensuremath{\rangle}$ matrix elements from the Coulomb excitation of ${}^{124,126,128}$Sn on a ${}^{12}$C target are presented. The extracted $B(E2)$ values decrease monotonically from the neutron midshell toward the ${}^{132}$Sn double-shell closure, despite a near constancy in the first ${2}^{+}$ level energy. Furthermore, Coulomb excitation of ${}^{124,126,128}$Sn on an enriched ${}^{50}$Ti target, combined with the results from the ${}^{12}$C target, provide a measure of the static quadrupole moments, $Q({2}_{1}{}^{+})$ (expected to be zero for a spherical shape). These new results confirm that the unstable neutron-rich ${}^{126,128}$Sn isotopes have deformations consistent with zero. The present study marks the first report on measured ${2}_{1}{}^{+}$ static quadrupole moments for unstable closed-shell nuclei.

A decay sequence above the I= 47 2 , 5.4 MeV level in 193Hg has been established through discrete γ-ray spectroscopy. The new energy levels exhibit single-particle character implying the dominant role of individual particle angular momentum alignment at moderate spins in the neutron-deficient Hg isotopes.

New results have been obtained on superdeformed states in [sup 190]Hg, [sup 191]Tl, and [sup 192]Tl. For [sup 190]Hg, the previously identified superdeformed band has been extended up to a rotational frequency of [Dirac h][omega] [ge] 0.40 MeV by combining data from several different experiments. The extracted dynamical moment of inertia J([sup 2]) vs [Dirac h][omega] exhibits a distinct change in slope at [Dirac h][omega] = 0.32 MeV. For [sup 191]Tl and [sup 192]Tl, two and six superdeformed bands have been identified in these nuclei, respectively. Six of these eight bands exhibit a smooth rise in J([sup 2]) with [Dirac h][omega] characteristic of the other superdeformed bands identified in this mass region while the remaining two bands which are in [sup 192]Tl show a constant J([sup 2]) with [Dirac h][omega]. This new result can be understood in terms of Pauli blocking of quasiparticle alignments in high-N intruder orbitals. The new result for [sup 190]Hg is interpreted as evidence of a band interaction at the highest frequencies due to the rotational alignment of a pair of quasiparticles into these same intruder orbitals. These two new features taken together represent the first conclusive evidence that the alignment of intruders is responsible formore » the smooth rise in J([sup 2]) seen in the other superdeformed bands of this mass region.« less

Intercellular adhesion molecule 1 (ICAM-1), a counter-receptor for lymphocyte function-associated antigen 1 on T cells, is critically important to a wide variety of adhesion-dependent leukocyte functions, including antigen presentation and target cell lysis. ICAM-1 expression by hepatocytes is increased in areas of inflammation and necrosis during chronic hepatitis B. Whether induction of ICAM-1 is due to the effect of inflammatory cytokines or involves a direct effect of the hepatitis B virus (HBV) remains unknown. In the present study, transfection of the HBV genome into human hepatoma cell lines resulted in enhanced expression of ICAM-1 protein and RNA in the absence of inflammation. Results of subgenomic transfections indicated that the HBV X protein (pX) induced ICAM-1 expression. Nuclear run-on assays showed that pX induced the ICAM-1 gene by increasing its rate of transcription. Although both pX and interferon gamma induced transcription of ICAM-1, addition of interferon gamma to cells expressing pX did not show an additive or synergistic effect. These results indicate that pX can directly regulate expression of ICAM-1 and may participate in the immunopathogenesis of HBV infection.

High-spin states in 175Re were studied using the 156Gd(23Na, 4n) reaction. Five rotational decay sequences have been identified and assigned to proton configurations. Eight strong interband transitions are observed connecting the members of the [ 303 ] 5 2 , 7 2 pseudo-spin doublet. Both the interband and intraband M1 and E2 transition rates can be understood in the pseudo SU(3) formalism with Coriolis mixing.

The g factor of the 2 1 + state in 132 52 Te, E ( 2 1 + ) = 0.9739 MeV , τ = 2.6 ps , was measured by the transient field technique applied to a radioactive beam. The development of an experimental approach necessary for work in radioactive beam environments is described. The result g = 0.28 ( 15 ) agrees with the previous measurement by the recoil-in-vacuum technique, but here the sign of the g factor is measured as well.

The use of constant-N contours in the (ω,λ) plane is demonstrated both for establishing diabolical points and for studying regularities and fluctuations in the spectrum of single-particle states. Likewise the average properties and fluctuations of empirical proton-neutron interactions, obtained from double differentials of the total energy with respect to N and Z, are discussed for the ground states of all even-even nuclei with N>40 and as a function of the rotational frequency for the lowest even spin, positive-parity decay sequence of deformed rare earth nuclei.

Purpose: Cyclooxygenase-2 (COX-2) inhibitors cause growth inhibition of human hepatocellular carcinoma cells but it remains unclear whether this is both COX-2 dependent and independent. The related mechanisms remain to be determined. The present study was aimed to determine the effect of celecoxib on growth of hepatocellular carcinoma cells and xenografts and the related mechanisms. Experimental Design: Both low COX-2 expressing PLC/PRF/5 and high COX-2 expressing HuH7 cells, and nude mice bearing hepatocellular carcinoma xenografts were used to study the effect and mechanisms of celecoxib on hepatocellular carcinoma cell growth. Results: Celecoxib resulted in a comparable growth inhibition of both hepatocellular carcinoma cells that was associated with decreased production of prostaglandin E2 and increased peroxisome proliferator-activated receptor γ in both cells. Addition of prostaglandin E2 only partially counteracted the effect of celecoxib on both cells. Celecoxib resulted in a significant reduction of retinoblastoma phosphorylation and DP1/E2F1 complex in both cells. Celecoxib caused a significant increase of apoptosis and activation of caspase-3 and caspase-9 in both cells. In nude mice inoculated with HuH7 cells, celecoxib resulted in decreased frequency and mean weight of hepatocellular carcinoma xenografts. Conclusion: The present study showed that celecoxib causes COX-2-dependent and COX-2-independent growth inhibition of hepatocellular carcinoma cells and xenografts by (a) decreased retinoblastoma phosphorylation and DP1/E2F1 complex; (b) increased activation of caspase-3 and caspase-9; and (c) increased expression of proliferator-activated receptor γ. The present study significantly extended our knowledge on the effect and mechanisms of celecoxib-induced inhibition of hepatocellular carcinoma cell growth.

The Holifield Radioactive Ion Beam Facility (HRIBF) at Oak Ridge is the first ISOL-type facility to provide beams of accelerated radioactive fission products. To generate these beams, products of fission induced by proton bombardment of a uranium carbide target are ionized, charge-exchanged in Cs vapor, and injected into the HRIBF tandem. Using a single stripper foil in the terminal, they can be accelerated to about 3 MeV per nucleon, ideal for Coulomb Excitation studies. Alternatively, they can be accelerated to energies above the Coulomb barrier by means of double-stripping, at the expense of a factor of about five in lost beam intensity. This paper reports on recent experiments using neutron-rich radioactive ion beams (RIBs) from the HRIBF facility. They have performed Coulomb excitation measurements of B(E2; 0{sup +} {yields} 2{sup +}) in {sup 126,128}Sn and {sup 132,134,136}Te, neutron transfer to single-particle states in {sup 135}Te, and fusion-evaporation reactions on light targets to study evaporation residues with {gamma}-{gamma}-recoil coincidence spectroscopy.

A new $7 \ensuremath{\mu}\mathrm{s}$ isomer in the drip line nucleus ${}^{140}\mathrm{Dy}$ was selected from the products of the ${}^{54}\mathrm{Fe}$ $(315 \mathrm{MeV}{)+}^{92}\mathrm{Mo}$ reaction by a recoil mass spectrometer and studied with recoil-delayed $\ensuremath{\gamma}\ensuremath{-}\ensuremath{\gamma}$ coincidences. Five cascading $\ensuremath{\gamma}$ transitions were interpreted as the decay of an ${I}^{\ensuremath{\pi}}{=8}^{\ensuremath{-}}$ ${\ensuremath{\nu}{9/2}^{\ensuremath{-}}[514]\ensuremath{\bigotimes}\ensuremath{\nu}{7/2}^{+}[404]}$ K isomer $({T}_{1/2}=7.0(5) \ensuremath{\mu}\mathrm{s})$ via the ground-state band. The probability of proton emission from ${}^{141}\mathrm{Ho}$ to the ${0}^{+}$ ground state and to the ${2}^{+}$ excited state in ${}^{140}\mathrm{Dy}$ is discussed.

Nonsuppurative destructive cholangitis (NSDC), a process of T-cell-mediated destruction of biliary epithelia observed in primary biliary cirrhosis (PBC), graft-versus-host disease (GVHD), and hepatic allograft rejection (HAR), also occurs in the B10. D2-->BALB/c model of GVHD. To advance studies of immunopathogenesis in this murine model, we immortalized 4 BALB/c intrahepatic biliary epithelial cell (BEC) lines as a reliable source of target cells. Freshly isolated BEC, as well as each cell line, expressed cytokeratin-19 (CK-19), epithelial cell adhesion molecule (EPCAM) and cystic fibrosis transmembrane conductance regulator (CFTR). None expressed albumin. Immortalized cells also expressed SV40 large T antigen. Class I major histocompatibility complex (MHC) was expressed by >97% of immortalized cells, while class II MHC and intercellular adhesion molecule-1 (ICAM-1) expression ranged from 0% to 13% and 14% to 74%, respectively. Interferon gamma (IFN-gamma) induced aberrant class II MHC expression and increased expression of ICAM-1. Variable proportions of immortalized cells expressed B7-1/B7-2 molecules and FAS. IFN-gamma significantly reduced B7-1 expression in some lines and significantly increased B7-2 expression in others. Allografts of freshly isolated and immortalized BEC injected into subscapular fat pads spontaneously formed duct-like structures. Inflammation was absent in BALB/c recipients. In contrast, inflammatory lesions in B10.D2 recipients were reminiscent of NSDC. Our results indicate that BALB/c-immortalized intrahepatic biliary cells: 1) retain the phenotype of mouse BEC; 2) can be induced to express aberrant class II MHC and increased ICAM-1; 3) express costimulatory B7-1/B7-2 molecules and FAS; and 4) spontaneously form duct-like structures after in vivo injection that are immunogenic in B10.D2 mice. These cell lines should facilitate future studies of the immunopathogenesis of NSDC in the B10. D2-->BALB/c murine model.

Thanks to an experimentation, this research studies nonconscious effects of two broadcast sponsorships on attitude toward a new brand. This brand sponsors two quasi-identical broadcasts: there is almost only one difference between them, their emotional content. Effects are recorded with indirect measures. The impact of humorous broadcast sponsorship (with two exposures) on brand is manifest and positive. The sad broadcast has no influence: the intensity of emotions has produced irrelevant thoughts which prevent the processing of the closing credits sponsor billboard. Results are in line with the new familiarity-misattribution model. No automatic transfer of semantic attributes from broadcasting to brand image is observed.

Measurement of fine structure in proton emission allows one to deduce the composition of the parent and daughter state’s wavefunction populated by proton emission. This paper presents new experimental data on the fine-structure decay of 146Tm, and a new interpretation of its decay properties.

The 2+2 state in 132Te is identified as the one-phonon MSS in a projectile Coulomb excitation experiment presenting a firm example of a MSS in unstable, neutron rich nuclei. The results of shell-model calculations based on the low-momentum interaction Vlow-k are in good agreement with experiment demonstrating the ability of the effective shell-model interaction to produce states of mixed-symmetry character.

Diagnostic testing for hepatitis C virus (HCV) infection currently is based on the presence of anti-HCV antibodies or a positive HCV RNA polymerase chain reaction (PCR) test. Although HCV RNA PCR is a sensitive and specific technique, widespread application is limited. Moreover, HCV RNA PCR is subject to false-positive reactions through contamination and is inherently difficult to standardize and quantitate. To overcome limitations of HCV RNA PCR, we produced both cDNA and riboprobes from a 241 nucleotide sequence of the 5' untranslated region of the HCV genome for slot hybridization. Hybridization was absent using normal human serum, horse serum, or hepatic cellular RNA from noninfected liver. Hybridization occurred predominantly with positive-stranded HCV RNA and was abolished by pretreatment with RNase A. Slot hybridization was performed on serum samples from 60 patients with chronic HCV infection and a positive HCV RNA PCR and 20 patients with liver diseases unrelated to HCV who had a negative HCV RNA PCR. Slot hybridization with cDNA and riboprobes showed concordance with HCV RNA PCR of 95 and 98.3%, respectively. There were no false-positive reactions in controls. The sensitivity of riboprobe hybridization was comparable to that of one stage HCV RNA PCR using 5' untranslated region primers. Riboprobe hybridization with the HCV H strain standard was positive in the dilution corresponding to 10(-6) chimpanzee infectious doses50/ml. The density of the hybridization signals correlated significantly with the mass of an RNA standard extracted from the liver of a patient with HCV infection. The relative quantities of HCV RNA in the sera of selected patients varied and were not correlated with the duration of disease or the histopathological stage. The highest relative quantities were associated with concurrent immunosuppression. We conclude that slot hybridization is a sensitive, specific alternative to HCV RNA PCR that can be directly quantitated using appropriate HCV RNA standards.

The systematics of the $\ensuremath{\pi}{h}_{11/2}\ensuremath{\bigotimes}\ensuremath{\nu}{h}_{11/2}$ and $\ensuremath{\pi}{h}_{11/2}\ensuremath{\bigotimes}\ensuremath{\nu}{s}_{1/2}$ isomeric configurations was studied for the odd-Z $N=77$ isotones near the proton drip line. The isomeric decays in $^{140}\mathrm{Eu}$, $^{142}\mathrm{Tb}$, $^{144}\mathrm{Ho}$, and $^{146}\mathrm{Tm}$ were measured by means of x-ray, \ensuremath{\gamma}-ray, and charged particle spectroscopy at the Recoil Mass Spectrometer at the Holifield Radioactive Ion Beam Facility (ORNL). The spin and parity of ${I}^{\ensuremath{\pi}}={8}^{+}$ and ${5}^{\ensuremath{-}}$ were deduced for the isomers in $^{140}\mathrm{Eu}$ and $^{142}\mathrm{Tb}$. New decay schemes were established, and the half-lives of the ${8}^{+}$ isomers were measured to be 302(4) ns for $^{140m2}\mathrm{Eu}$ and 25(1) \ensuremath{\mu}s for $^{142m2}\mathrm{Tb}$. No evidence for the expected ${1}^{+}$ ground-state was found in the $^{144}\mathrm{Ho}$ decay data. The proton-emission from $^{146}\mathrm{Tm}$ was restudied. Five proton transitions were assigned to two proton-emitting states. The half-lives of 198(3) ms and 68(3) ms and the spin and parity values of ${I}^{\ensuremath{\pi}}={10}^{+}$ and ${5}^{\ensuremath{-}}$ were established for $^{146m}\mathrm{Tm}$ and $^{146\mathrm{gs}}\mathrm{Tm}$, respectively. For the first time for an odd-odd nucleus, the interpretation of the observed decay properties and structure of the proton-emitting states was made by accounting for deformation and proton and neutron coupling to the core excitations. A complex wave-function structure was obtained, with dominating components of $\ensuremath{\pi}{h}_{11/2}\ensuremath{\bigotimes}\ensuremath{\nu}{h}_{11/2}$ for the ${10}^{+}$ isomer and $\ensuremath{\pi}{h}_{11/2}\ensuremath{\bigotimes}\ensuremath{\nu}{s}_{1/2}$ for the ${5}^{\ensuremath{-}}$ ground state.

The role of hepatitis C virus (HCV) infection in fulminant hepatic failure is controversial. The frequency of serum HCV RNA positivity in previously reported patients with fulminant hepatic failure (FHF) of indeterminate cause ranged from 0 to 12% in the United States and Europe and from 43% to 59% in Asia. We assessed serum HCV RNA using polymerase chain reaction (PCR) and oligoprimers from the 5'UTR of the HCV genome in 26 consecutive patients with FHF. Another laboratory independently performed PCR on 21 of the serum samples using different oligoprimers from the 5'UTR and NS3 region of the HCV genome. Serum HCV RNA was detected in two of seven (28%) patients with hepatitis B, 9 of 15 (60%) with an indeterminate cause, and in none with hepatitis A (n = 2) or drug-induced hepatotoxicity (n = 2). HCV RNA PCR results were concordant between both laboratories in 17 of 21 (81%) of samples. In patients with an indeterminate cause, HCV RNA positivity was significantly associated with the transmission risk factor of low socioeconomic status and Hispanic ethnicity. Eighteen patients underwent liver transplantation (LT) and 15 (83%) survived. Among patients with FHF of indeterminate cause, recurrent or acquired HCV infection after transplantation occurred in three of five (60%) and one of four (25%) patients, respectively. Three of four (75%) patients with hepatitis C virus infection post-LT also developed histologic hepatitis. HCV appears to be the causative agent of a substantial number of cases of FHF classified as indeterminate in the Los Angeles area. Differences in patient populations or risk factors may explain the discordant incidences of HCV infection in FHF observed among different programs.

Onboard DC/DC power supply has the features of small cubic measure, without ground point PE to link Y capacitor, as a result, it can’t take common mode choke to reduce electrical magmatic compatibility which is very difficult to resolve in low-frequency stage. This article shows a kind of good methods to resolve this problem. The method improves the way of wilding of planar voltage transformer to reduce parasitic capacitance of both sides, which can modify 12dB in low-frequency stage.