2,169 results on '"Cataldo P"'
Search Results
2. A Multidisciplinary Approach Is Beneficial in Atopic Dermatitis
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Paolo Amerio, Silvia Mariel Ferrucci, Marco Galluzzo, Maddalena Napolitano, Alessandra Narcisi, Anna Levi, Sara Di Fino, Chiara Palladino, Cataldo Patruno, and Mariateresa Rossi
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Moderate-to-severe atopic dermatitis ,Multidisciplinary approach ,Holistic care ,Dermatology ,RL1-803 - Abstract
Abstract Atopic dermatitis (AD) is a highly heterogeneous chronic inflammatory skin disorder that is frequently associated with a plethora of comorbidities. AD is, therefore, considered a systemic disease impacted by a considerable burden and leading to poor quality of life, especially in patients with moderate-to-severe disease. Since atopic and non-atopic comorbidities can further worsen the disease course, accurate establishment of the patient’s individual intrinsic risk profile and needs is crucial and may help in guiding the selection of the best treatment option. Better quality of care for patients with AD can be delivered through a multidisciplinary team led by a dermatologist, for comprehensive patient management. The implementation of a multidisciplinary approach for AD could enhance the delivery of optimised and safe treatments, improve the standard of care and patient outcomes in the short and long term, and prevent or delay the lifelong impact of uncontrolled AD. Understanding the unmet needs, assessing correctly the patient risk profile and enhancing the shared patient–physician decision-making process can lead to disease control and quality-of-life improvement, especially in the context of the introduction of newer treatment for AD. This narrative review is a call for more data to establish standardised patient profiles and multidisciplinary strategies in AD management. In view on the fast-evolving treatments for AD, this review aims at highlighting the importance of a multidisciplinary approach to a comprehensive assessment and holistic care in patients with moderate-to-severe AD.
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- 2024
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3. Clinical Translation and Implementation of a Bioartificial Pancreas Therapy: A Qualitative Study Exploring the Perspectives of People With Type 1 Diabetes
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Dide de Jongh, MSc, Silke Lapré, BSc, Behiye Özcan, MD, PhD, Robert Zietse, MD, PhD, Eline M. Bunnik, PhD, Emma K. Massey, PhD, the VANGUARD consortium, Ekaterine Berishvili, Laura Mar Fonseca, Fanny Lebreton, Kevin Bellofatto, Juliette Bignard, Jochen Seissler, Leila Wolf-van Buerck, Mohsen Honarpisheh, Yichen Zhang, Yutian Lei, Monika Pehl, Antonia Follenzi, Christina Olgasi, Alessia Cucci, Chiara Borsotti, Simone Assanelli, Lorenzo Piemonti, Antonio Citro, Silvia Pellegrini, Cataldo Pignatelli, Francesco Campo, Olivier Thaunat, Morgane Fouché, Devi Mey, Chiara Parisotto, Giovanna Rossi, Patrick Kugelmeier, Markus Mühlemann, Karolina Pal-Kutas, Marco Cavallaro, Julia Götz, and Jeanette Müller
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Surgery ,RD1-811 - Abstract
Background. The development of a hybrid beta-cell replacement approach, referred to as a personalized, transplantable bioartificial pancreas (BAP), holds promise to treat type 1 diabetes (T1D). This interview study aimed to explore patients’ expectations, needs, concerns, and considerations when considering to undergo a BAP transplantation. Research Design and Methods. Semistructured interviews were conducted with 24 participants diagnosed with T1D. Data collection stopped once data saturation was reached. Audio recordings of the interviews were transcribed verbatim. The interviews were independently analyzed by 2 researchers. A qualitative content analysis using an inductive approach was used. Results. Three main themes emerged as follow: (1) hoped-for benefits, (2) concerns and decision-making considerations, and (3) procedural aspects. First, the participants expected benefits across medical, psychological, and social domains. Over these 3 domains, 9 subthemes were identified, including improved clinical outcomes, a cure for diabetes, more headspace, emotional relief, a shift in responsibility, protection of privacy, improved flexibility in daily life, less visible diseases, and improved relationships with others. Second, concerns and considerations about undergoing a BAP transplant comprised adverse events, the functionality of the BAP, the surgery procedure, the biological materials used, the transplant location, and the intrusiveness associated with follow-up care. Finally, procedural considerations included equitable access, patient prioritization, and trust and control. Conclusions. Incorporating insights from this study into the clinical development and implementation of the BAP is crucial to ensure alignment of the product and procedures with the needs and expectations of people with T1D.
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- 2024
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4. Clinical and economic burden of respiratory syncytial virus in children aged 0–5 years in Italy
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Melania Dovizio, Chiara Veronesi, Fausto Bartolini, Arturo Cavaliere, Stefano Grego, Romina Pagliaro, Cataldo Procacci, Loredana Ubertazzo, Lorenzo Bertizzolo, Barbara Muzii, Salvatore Parisi, Valentina Perrone, Eugenio Baraldi, Elena Bozzola, Fabio Mosca, and Luca Degli Esposti
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Children ,Monoclonal antibodies ,Infants ,Prevention of RSV ,Real-world evidence ,Respiratory syncytial virus ,Pediatrics ,RJ1-570 - Abstract
Abstract Background Respiratory syncytial virus (RSV) is among the leading causes of hospitalization due to lower respiratory tract infections (LRTIs) in children younger than 5 years worldwide and the second cause of infant death after malaria. RSV infection occurs in almost all the infants before the second year of life with variable clinical severity, often requiring medical assistance. This analysis investigated patients aged 0–5 years with RSV infection focusing on epidemiology, clinical features, and economic burden of RSV-associated hospitalizations in a setting of Italian real clinical practice. Methods An observational retrospective analysis was conducted on administrative databases of healthcare entities covering around 2.6 million residents of whom 120,000 health-assisted infants aged
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- 2024
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5. Head–neck melanoma: Clinical, histopathological and prognostic features of an Italian multicentric study
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Giusy Schipani, Steven P. Nisticò, Pietro Quaglino, Simone Ribero, Giuseppe Gallo, Vincenzo Maione, Giampiero Girolomoni, Paolo Rosina, Mauro Alaibac, Francesco Messina, Alessandro Gatti, Giuseppe Stinco, Cinzia Buligan, Sara Bassoli, Francesca Farnetani, Alessandro Borghi, Davide Melandri, Riccardo Sirna, Luca Feci, Stefano Simonetti, Luca Stingeni, Annamaria Offidani, Valerio Brisigotti, Anna Campanati, Stefano Calvieri, Giulia Spallone, Elisabetta Botti, Vincenzo Panasiti, Gianluca Pagnanelli, Massimiliano Scalvenzi, Gabriella Fabbrocini, Claudia Costa, Vincenzo Schirripa, Francesco Borgia, Laura Atzori, Elisabetta Scali, Maria Passante, Fabrizio Guarneri, and Cataldo Patruno
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head–neck melanoma ,location of melanoma ,Dermatology ,RL1-803 ,Diseases of the genitourinary system. Urology ,RC870-923 - Abstract
Abstract Background Primitive location of melanoma could be a relevant prognostic factor. As regards the scalp, some studies indicate a particularly aggressive biological behaviour for this anatomical localisation. Objectives In this multicentric study, data regarding head–neck melanoma (HNM) have been revised. Methods The design of the study included two main phases. In this retrospective study, data regarding HNM have been collected and analysed. Results In summary, our data suggest that the posterior neck is the area most affected by thicker melanomas. Cheeks and neck melanoma are associated with reduced disease‐free years of life and overall survival compared with all other sites of HNM. Conclusions This study provides useful information in defining the clinical features of HNM, thus improving diagnosis and treatment strategies.
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- 2024
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6. Injection site reactions after dupilumab or tralokinumab for atopic dermatitis
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Fabrizio Martora, Cataldo Patruno, Silvia D’Ascenzo, and Maddalena Napolitano
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Atopic dermatitis ,tralokinumab ,dupilumab ,Dermatology ,RL1-803 - Abstract
AbstractBackground: Injection site reaction (ISR) is a local phenomenon defined as a constellation of symptoms, including swelling, erythema, pruritus, and pain around the site of injection.Objective: ISR is reported as a frequent adverse event after subcutaneous injection (SCI) of several biologics.Methods: We performed an observational real-life study to compare dupilumab and tralokinumab as regards ISR, analysing frequency, duration and intensity of symptoms related to SCI. From January 2023 to June 2023, we enrolled adult patients affected by moderate to severe AD and being on dupilumab or tralokinumab treatment. A 12 items questionnaire was administered to all enrolled patients.Results and conclusions: Three hundred and ninety-two patients were included. ISR was a frequent occurrence in both the treatment groups, with tralokinumab causing ISR more frequently than dupilumab. However, the reactions were generally mild and no patient stopped therapy.
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- 2024
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7. Case Report: Role of numerical simulations in the management of acute aortic syndromes
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Antonio Rizza, Vincenzo Castiglione, Katia Capellini, Cataldo Palmieri, Emanuele Gasparotti, Sergio Berti, and Simona Celi
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penetrating aortic ulcer ,acute aortic syndrome ,aortic endograft ,numerical simulations ,computational fluid dynamics ,Diseases of the circulatory (Cardiovascular) system ,RC666-701 - Abstract
Penetrating aortic ulcer (PAU) represents a subset of acute aortic syndromes characterized by high rupture risk and management challenges, particularly in elderly patients with significant comorbidities. This case report showcases a 75-year-old patient with a history of coronary artery bypass graft (CABG) and with multiple PAUs involving the aortic arch, deemed unfit for conventional open surgery. A branched aortic endograft with a pre-cannulated side component for the left subclavian artery (LSA) was employed to preserve the patency of the previous CABG. Two computational fluid dynamics (CFD) simulations and a morphological analysis were performed on the pre- and post-intervention aortic configurations to evaluate changes in flow rate and pressure drop at LSA level and differences in the lumen size. The results revealed a decrease in the flow rate equal to 2.38% after the intervention and an increase in pressure drop of 4.48 mmHg, while the maximum differences in LSA cross-sectional areas and diameters were 1.49 cm2 and 0.64 cm, respectively. Minimal alteration in LSA blood flow due to the chosen intervention approach confirmed the effectiveness of the selected unibody design endograft with LSA preservation, ensuring myocardial perfusion. Therefore, CFD simulations demonstrate to be a powerful tool to evaluate the hemodynamic consequences of interventions by accurately estimating the main fluid dynamic parameters.
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- 2024
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8. Blockchain-Backed Sustainable Management of Italian Tomato Processing Industry
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Sajid Safeer and Cataldo Pulvento
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blockchain ,tomato industry ,supply chain ,sustainability ,smart contract ,Agriculture (General) ,S1-972 - Abstract
This study addresses significant concerns highlighted by the European Parliament regarding the decline of the Italian tomato processing industry, which possess a threat to Italy’s culinary heritage and global market position. This research offers a solution that leverages blockchain technology to enhance transparency, traceability and operational efficiency within the tomato supply chain. By integrating Solidity, Remix IDE, MetaMask wallet and Sepolia Testnet, our proposed model establishes a robust blockchain-based smart-contract system. This system actively engages cultivators, wholesalers, retailers and end-users facilitating seamless real-time updates across the entire supply chain. Implementing this model in key tomato-producing regions such as Apulia, utilizing platforms like Mainnet or Hyperledger Fabric, aims to stabilize the industry. Furthermore, this study promotes automating smart contracts, integrating IoT devices and developing decentralized applications (DApps). This strategy ensures transparency for end-users, enhances organic food availability and mitigates contamination risks. This study also recommends government involvement to upgrade transportation and storage facilities, aiming to reduce post-harvest losses. This research establishes the groundwork for the sustainable management of the Italian tomato processing industry.
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- 2024
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9. A Bibliometric Analysis of Chickpea Agronomic Practices in the World During 45 Years of Scientific Research
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Claudio Calia, Cataldo Pulvento, Mohamed Houssemeddine Sellami, Luigi Tedone, Claudia Ruta, and Giuseppe De Mastro
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agronomic practices ,bibliometric analysis review ,Cicer arietinum L ,Plant culture ,SB1-1110 - Abstract
ABSTRACT Chickpea (Cicer arietinum L.) cultivation practices underwent significant transformation in recent decades due to advancements in scientific knowledge and the need for sustainable, productive farming systems. In this study, a bibliometric analysis of scientific publications from 1977 to 2023 on chickpea agronomic practices was conducted, revealing critical insights. India, as the world's leading chickpea producer, plays a pivotal role, not only in production but also as a significant contributor to scholarly research and international collaborations. The choice of journals for publication is found to influence research impact. Analysis of research trends using co‐occurrence networks of keywords reveals evolving focuses, with a recent shift towards qualitative aspects, such as protein content and nutritional quality, as well as sustainable agricultural practices. The study also emphasizes the necessity for further research on chickpea quality characteristics, strategies to mitigate antinutritional factors, yield optimization, and the impact of climate change on chickpea cultivation. Ultimately, chickpea cultivation research holds great promise in contributing to global food security and environmental sustainability. This bibliometric analysis provides a comprehensive overview of chickpea cultivation research and offers valuable insights for researchers, policymakers, and stakeholders as they navigate the future of sustainable agriculture and the quest for protein‐rich food production while minimizing the environmental footprint.
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- 2024
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10. Long-term efficacy and safety of secukinumab in real life: a 240 weeks multicenter study from Southern Italy
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Stefano Dastoli, Maria Passante, Francesco Loconsole, Edoardo Mortato, Anna Balato, Vincenzo Piccolo, Claudio Guarneri, Laura Macca, Eugenio Provenzano, Giancarlo Valenti, Domenico D’Amico, Giuseppe Micali, Maria Letizia Musumeci, Giovanni Palazzo, Caterina Foti, Paolo Romita, Gabriella Fabbrocini, Matteo Megna, Ilaria Sammarra, Luigi Bennardo, and Cataldo Patruno
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biologic drugs ,long-term therapy ,psoriasis area and severity index (pasi) ,real-world ,secukinumab ,Dermatology ,RL1-803 - Abstract
Background Long-term real-life data on secukinumab use in psoriasis are limited. Objectives Determine the long-term effectiveness of secukinumab in moderate-to-severe psoriasis in real-life. Methods Multicenter retrospective study analyzing data from adult patients treated with secukinumab for at least 192 weeks and up to 240 weeks in Southern Italy, between 2016 and 2021. Clinical data, including concurrent comorbidities and prior treatments were collected. Effectiveness was assessed by Psoriasis Area and Severity Index (PASI), Body Surface Area (BSA), Dermatology Life Quality Index (DLQI) scores at the initiation of secukinumab and at weeks 4, 12, 24, 48, 96, 144, 192, and 240. Results Two hundred and seventy-five patients (174 males), mean age 50.80 ± 14.78 years, were included; 29.8% had an uncommon localization, 24.4% psoriatic arthritis, 71.6% comorbidities. PASI, BSA, and DLQI improved significantly from week 4 and continued to improve over time. Between weeks 24 and 240, PASI score was mild (≤10) in 97–100% of patients, 83–93% had mild affected BSA (BSA ≤ 3), and 62–90% reported no effect of psoriasis on their quality of life (DLQI 0–1). Only 2.6% of patients reported adverse events and no patient discontinued the treatment during the study period. Conclusions Secukinumab effectiveness in the long-term treatment of psoriasis is confirmed in real-world.
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- 2023
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11. A 52-week multicenter retrospective real-world study on effectiveness and safety of dupilumab in children with atopic dermatitis aged from 6 to 11 years
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Cataldo Patruno, Gabriella Fabbrocini, Giuseppe Lauletta, Valeria Boccaletti, Cristiana Colonna, Riccardo Cavalli, Iria Neri, Michela Ortoncelli, Donatella Schena, Luca Stingeni, Katharina Hansel, Vincenzo Piccolo, Veronica Di Brizzi, Concetta Potenza, Ersilia Tolino, Luca Bianchi, Sara Manti, Rocco De Pasquale, Vito Di Lernia, Lucia Caminiti, Elena Galli, Paola Coppo, Andrea Chiricozzi, Clara De Simone, Cristina Guerriero, Fabrizio Giuseppe Amoruso, Eugenio Provenzano, Salvatore Leonardi, Amelia Licari, Gian Luigi Marseglia, Antonino Palermo, Sabrina Di Pillo, Daniele Russo, Viviana Moschese, Vincenzo Patella, Tiziana Peduto, Caterina Ferreli, Paola Zangari, Federica Veronese, Samantha Federica Berti, Michaela Gruber, Elena Pezzolo, Stefania Termine, Rosanna Satta, Federica Dragoni, Maria Esposito, Maria Concetta Fargnoli, Paolo Chiodini, Ylenia Vallone, Francesca di Vico, Vincenzo Picone, and Maddalena Napolitano
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atopic dermatitis ,children ,dupilumab ,real-world data ,Dermatology ,RL1-803 - Abstract
Background: Dupilumab has been shown to be a safe and effective drug for the treatment of atopic dermatitis (AD) in children from 6 months to 11 years in randomized clinical trials. Aim: The aim of this real-life study was to determine the effectiveness in disease control and safety of dupilumab at W52 in moderate-to-severe AD children aged 6-11 years. Methods: All data were collected from 36 Italian dermatological or paediatric referral centres. Dupilumab was administered at label dosage with an induction dose of 300 mg on day 1 (D1), followed by 300 mg on D15 and 300 mg every 4 weeks (Q4W). Treatment effect was determined as overall disease severity, using EASI, P-NRS, S-NRS and c-DLQI at baseline, W16, W24, and W52. Ninety-six AD children diagnosed with moderate-to-severe AD and treated with dupilumab were enrolled. Results: Ninety-one (94.8%) patients completed the 52-week treatment period and were included in the study. A significant improvement in EASI score, P-NRS, S-NRS and c-DLQI was observed from baseline to weeks 16, 24 and 52. Conclusions: Our real-life data seem to confirm dupilumab effectiveness and safety in paediatric patients. Moreover, our experience highlighted that patients achieving clinical improvement at W16 preserved this condition over time.
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- 2023
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12. Alien and native species in Italian marine and transitional waters
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Cristina Di Muri, Tamara Lazic, Ilaria Rosati, Cataldo Pierri, Angela Boggero, Giuseppe Corriero, and Alberto Basset
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non-indigenous species ,introduced species ,biodiv ,Biology (General) ,QH301-705.5 - Abstract
Biological invasions are one of the major threats to the ecosystem structure and functioning. After the initial introduction, frequently mediated by human activities, alien species can overcome different biogeographical and ecological barriers and determine severe impacts on native biodiversity and socio-economic activities. The Italian peninsula is located at the intersection of large trade routes within the Mediterranean Sea. Such position, along with the intense commercial activity and the high population density of the Italian coast, are considered important drivers of alien species in Italian marine and transitional ecosystems. The Italian peninsula, however, is also one of the regions with the highest native species richness within the Mediterranean Sea and, therefore, it is crucial to account for both alien and native species diversity when estimating the impact of biological invasion. Yet, such comprehensive information is frequently scattered across several biodiversity information systems and databases.Here, two datasets with alien and native species records in Italian marine and transitional waters are described. These datasets, created for the LifeWatch Italy case study on alien species, are the result of a large-scale collaboration involving experts working across the whole range of taxonomic diversity. The marine dataset includes a total of 12,219 records belonging to 3,772 species gathered from 91 investigated sites and seven EUNIS habitats. The dataset on transitional waters biodiversity includes 3,838 records belonging to 2,019 species found in 23 locations and four EUNIS habitats. Alien species were recorded in both marine and transitional waters, accounting respectively for 140 and 171 biological records belonging to 59 and 97 species. These occurrence data can be used for further research studies or management purposes, including the evaluation of the invasion risk and the formulation of alien species control and management plans. Furthermore, these compiled datasets can be used as input data for the Biotope vulnerability case study of LifeWatch ERIC, which offers a number of ICT services for the calculation of the incidence and of the impact of alien species on European biotopes.
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- 2023
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13. Directed self-assembly of a xenogeneic vascularized endocrine pancreas for type 1 diabetes
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Antonio Citro, Alessia Neroni, Cataldo Pignatelli, Francesco Campo, Martina Policardi, Matteo Monieri, Silvia Pellegrini, Erica Dugnani, Fabio Manenti, Maria Chiara Maffia, Libera Valla, Elisabeth Kemter, Ilaria Marzinotto, Cristina Olgasi, Alessia Cucci, Antonia Follenzi, Vito Lampasona, Eckhard Wolf, and Lorenzo Piemonti
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Science - Abstract
Cell therapy for diabetes requires the combination of bioengineering and new sources of beta cells. Here, the authors report a self-assembly platform based on neonatal pig islets, human endothelial cells and native organ extracellular matrix, which improves ex vivo islet maturation and in vivo function in a mouse model of diabetes.
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- 2023
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14. A Dataset of Benthic Species from Mesophotic Bioconstructions on the Apulian Coast (Southeastern Italy, Mediterranean Sea)
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Maria Mercurio, Guadalupe Giménez, Giorgio Bavestrello, Frine Cardone, Giuseppe Corriero, Jacopo Giampaoletti, Maria Flavia Gravina, Cataldo Pierri, Caterina Longo, Adriana Giangrande, and Carlotta Nonnis Marzano
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Benthos ,scleractinian reefs ,oyster reefs ,mesophotic zone ,southern Adriatic Sea ,Bibliography. Library science. Information resources - Abstract
Marine bioconstructions are complex habitats that represent a hotspot of biodiversity. Among Mediterranean bioconstructions, those thriving on mesophotic bottoms on southeastern Italian coasts are of particular interest due to their horizontal and vertical extension. In general, the communities that develop in the Mediterranean twilight zone encompassed within the first 30 m of depth are better known, while relatively few data are available on those at greater depths. By further investigating the diversity and structure of mesophotic bioconstructions in the southern Adriatic, we can improve our understanding of Mediterranean biodiversity while developing effective conservation strategies to preserve these habitats of particular interest. The dataset reported here comprises records of benthic marine taxa from algae and invertebrate mesophotic bioconstructions investigated at six sites along the southern Adriatic coast of Italy, at depths between approximately 25 and 65 m. The dataset contains a total of 1718 records, covering 11 phyla and 648 benthic taxa, of which 580 were recognized at the species level. These data could provide a reference point for further investigations with descriptive or management purposes, including the possible assessment of mesophotic bioconstructions as refuges for shallow-water species.
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- 2024
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15. Vitiligo during dupilumab therapy
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Vincenzo Picone, MD, Maddalena Napolitano, MD, Ginevra Torta, MD, Gabriella Fabbrocini, MD, PhD, and Cataldo Patruno, MD, PhD
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atopic dermatitis ,dupilumab ,vitiligo ,Dermatology ,RL1-803 - Published
- 2023
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16. Cropping practices of globe artichoke: a bibliometric study
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Donato Stea, Mohamed Houssemeddine Sellami, Claudia Ruta, Cataldo Pulvento, and Giuseppe De Mastro
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Cynara cardunculus L. var. scolymus (L.) Fiori ,keywords co-occurrence analysis ,agronomic practices ,co-citation analysis ,bibliometric analysis ,Nutrition. Foods and food supply ,TX341-641 ,Food processing and manufacture ,TP368-456 - Abstract
Globe artichoke is a food plant that is gaining increasing interest due to its commercial, nutritional and therapeutic value; research and development in the field of agriculture for this crop encompasses several key areas to enhance cultivation, productivity, and overall sustainability. In this study a bibliometric analysis of literature has been carried out in order to identify research areas and research gaps in cropping management of globe artichoke under field conditions, and to identify new research opportunities. The analysis revealed that published articles on the agronomic practices of globe artichoke under field conditions, is concentrated in Europe (70.56%), followed by North America (10%) and South America (7.22%). On the vastly arid Australian continent, there is a dearth of such studies. Italy, Spain and USA, were the most productive countries in the globe artichoke research field. The analysed papers have also shown that agronomic practices such as irrigation (wastewater and brackish water), fertilization, diseases management and plant breeding are the most studied cropping practices that affect artichoke yield and head quality. Finally, this study highlights the importance of integrating innovative methods like meta-analysis to gain a more holistic comprehension of how agricultural practices impact globe artichoke and to lays the groundwork for future research endeavours.
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- 2023
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17. Different behavioral strategies of two sympatric seahorses: habitat availability and increased density of Hippocampus guttulatus alter the behavior of Hippocampus hippocampus
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Davide Spatafora, Michele Gristina, Federico Quattrocchi, Cataldo Pierri, Tamara Lazic, and Jorge Palma
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behavioral plasticity ,Hippocampus guttulatus ,Hippocampus hippocampus ,climate change ,seahorse ,coastal habitat ,Science ,General. Including nature conservation, geographical distribution ,QH1-199.5 - Abstract
In the light of future ocean warming scenarios and habitat fragmentation, coastal fishes must adjust their physiological and behavioral traits to face the combined effect of global warming and ecological interactions. Seahorses (Hippocampus spp.) are charismatic fishes with peculiar life cycle traits, which make them vulnerable to several anthropic pressures and natural disturbances. In this study, we investigated the behavior of two sympatric seahorse species, the long-snouted Hippocampus guttulatus (Cuvier, 1829) and the short-snouted Hippocampus hippocampus (Linnaeus, 1758). Specifically, we carried out two manipulative experiments to assess (i) the effect of temperature and habitat availability on both H. hippocampus and H. guttulatus behavior and (ii) the effect of temperature and an increased density of H. guttulatus (by 3×) on the activity level of congeneric species H. hippocampus. Our results showed that +3°C warming did not affect seahorse behavior in both experiments, suggesting greater behavioral tolerance to thermal variation. However, a significant reduction of the active behavior of H. hippocampus was observed when the artificial habitat was introduced in the tank, while H. guttulatus maintained its activity. Furthermore, a significant decrease of the H. hippocampus activity was observed with an increased relative dominance of H. guttulatus. Our results suggest that both increased density of H. guttulatus and habitat availability, but not ocean warming, will affect the behavior of H. hippocampus. Therefore, different interspecific behavioral strategies may occur, thus affecting the distribution of the two species among shallow habitats when they occur in sympatry.
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- 2023
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18. Life-threatening paradoxical thromboembolism in a patient with patent foramen ovale
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Antonio Rizza, Francesco Negro, Tommaso Gasbarri, Roberto Arpesani, Baldassare Ferro, Paolo Roncucci, Cataldo Palmieri, Simone Sorbo, Emilio Maria Pasanisi, Marco Solinas, and Sergio Berti
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Pulmonary embolism ,Deep vein thrombosis ,Patent foramen ovale ,Paradoxical embolization ,Diseases of the circulatory (Cardiovascular) system ,RC666-701 - Abstract
Abstract Background Venous thromboembolism represents the third most frequent acute cardiovascular syndrome worldwide. Its clinical manifestations are deep vein thrombosis and/or pulmonary embolism. Despite a considerable mortality, diagnosis is often missed. Case presentation We report the management of a female patient with high-risk pulmonary thromboembolism treated initially with thromboaspiration, complicated by embolus jailing in a patent foramen ovale. In this situation, left cardiac chambers and systemic circulation were jeopardized by this floating embolus. Conclusions High-risk pulmonary embolism requires reperfusion strategy but sometimes mechanical thromboaspiration may be not fully successful; transesophageal echocardiography led to a prompt diagnosis of this unexpected finding; in this very particular case, open surgery represented a bail-out procedure to avoid cerebral and systemic embolism.
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- 2022
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19. Dupilumab for the treatment of adult atopic dermatitis in special populations
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Cataldo Patruno, Luca Potestio, Massimiliano Scalvenzi, Teresa Battista, Flavia Raia, Vincenzo Picone, Gabriella Fabbrocini, and Maddalena Napolitano
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atopic dermatitis ,special populations ,treatment ,dupilumab ,Dermatology ,RL1-803 - Abstract
Background Special populations (SPs) involve people who require additional consideration in clinical research. Effectiveness of treatment or occurrence of side effects may be different in SPs with respect to not-SPs. Objectives To retrospectively compare the effectiveness and safety of dupilumab in AD treatment of SPs versus not-SPs. Methods A 52-weeks retrospective study was performed enrolling patients with a diagnosis of moderate-to-severe AD undergoing treatment with dupilumab at labeled dosage. Patients were divided in Group A (SPs patients) and Group B (not-SPs patients). Disease severity was assessed using Eczema Area Severity Index (EASI), Pruritus–Numerical Rating Scale (P-NRS), and Dermatology Life Quality Index (DLQI) score at baseline and after 4 weeks (W4), W16, W24, and W52. Results A total of 263 patients were enrolled and divided in Group A (25) and Group B (238). SPs included history of cancer, severe kidney failure, viral hepatitis, neurological diseases, acquired immunodeficiency syndrome, and transplanted patients. A statistically significant reduction of EASI, DLQI, and P-NRS was assessed in both groups at each follow-up visit (p
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- 2022
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20. Drug Survival of Upadacitinib and Predicting Factors of Discontinuation in Adult Patients Affected by Moderate-to-Severe Atopic Dermatitis: An Italian Multicenter Analysis
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Elena Pezzolo, Michela Ortoncelli, Silvia Mariel Ferrucci, Mario Bruno Guanti, Donatella Schena, Maddalena Napolitano, Mariateresa Rossi, Caterina Foti, Domenico D’Amico, Giuseppe Fabrizio Amoruso, Pietro Morrone, Simone Ribero, Francesca Barei, Matteo Biagi, Enrico Pascucci, Cataldo Patruno, Piergiacomo Calzavara Pinton, Paolo Romita, Luigi Gargiulo, Alessandra Narcisi, and Luigi Naldi
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atopic dermatitis ,drug survival ,pathogenesis ,type 2 inflammation ,Th2 response ,treatment ,Medicine - Abstract
Background: Limited real-world data are available on upadacitinib drug survival in patients with atopic dermatitis (AD). Objectives: To investigate upadacitinib drug survival, and the reasons and predictors of drug discontinuation in AD patients. Methods: All consecutive patients aged 18–75 years, affected by moderate-to-severe AD, and treated with upadacitinib for more than 1 month at dermatological clinics were included during November 2020–August 2023. Upadacitinib survival was investigated through Kaplan–Meier survival analysis and the predictors through multivariable logistic regression analysis. Results: Overall, 325 adult AD patients (mean (SD) age, 38.6(15.6) years) had a 1-year and 1.5-year upadacitinib drug survival of 91.5% and 80.2%, respectively. The main reasons for drug discontinuation (25/325, 7.7%) were adverse events (4.9%), including cutaneous or infectious diseases (1.5%), such as acne and herpes zoster; blood test changes (1.2%), including hypercholesterolemia, creatine phosphokinase or liver enzyme elevation, and lymphopenia; urinary or respiratory infections (0.9%); deep venous thrombosis (0.3%); malignancies (0.3%); loss of consciousness (0.3%); and arthralgias (0.3%); followed by ineffectiveness (0.6%). No specific characteristic was significantly associated with an increased risk of upadacitinib discontinuation. Conclusions: Our findings show that upadacitinib was effective in moderate-to-severe AD after more than 1 year of continuous treatment but point to the need for clinical and laboratory monitoring of patients.
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- 2024
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21. Preliminary Outcomes of Zone 2 Thoracic Endovascular Aortic Repair Using Castor Single-Branched Stent Grafts: A Single-Center Experience
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Antonio Rizza, Giancarlo Trimarchi, Silvia Di Sibio, Luca Bastiani, Michele Murzi, Cataldo Palmieri, Ilenia Foffa, and Sergio Berti
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aortic arch pathologies ,type B aortic dissections ,endovascular approach ,single-branched stent graft ,safety ,Medicine - Abstract
In the context of thoracic endovascular aortic repair (TEVAR), the reconstruction of the left subclavian artery (LSA) has emerged as a crucial component in establishing a sufficient proximal landing zone. However, the technical difficulty of these procedures raises the possibility of endoleaks and neurological consequences. Single-branched stent grafts offer good anchoring and LSA flow for these patients. This study evaluates the feasibility of utilizing novel single-branched stent grafts in the treatment of distal aortic arch disease, identifying good results in the short and medium term. From September 2019 to March 2023, TEVAR and revascularized LSA were performed on ten patients at the Ospedale del Cuore—FTGM in Massa, Italy, using Castor single-branched thoracic aortic stent grafts (Microport Medical, Shanghai, China). The authors’ first findings demonstrated that, after an average follow-up of one year, the Castor branching aortic stent graft system was safe and achieving an appropriate proximal landing zone and maintaining sufficient LSA perfusion was possible. With regard to the endovascular treatment of distal aortic arch diseases, this product offers a compelling substitute for surgery. For the purpose of assessing the long-term effectiveness of this approach, the follow-up period should be extended.
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- 2023
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22. Establishment of an Efficient In Vitro Propagation Protocol for Cannabis sativa L. subsp. ruderalis Janish
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Giuseppe N. Basile, Luigi Tedone, Cataldo Pulvento, Giuseppe De Mastro, and Claudia Ruta
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Finola ,hemp ,auto-flowering ,clonal propagation ,micropropagation ,Plant culture ,SB1-1110 - Abstract
Cannabis sativa L., subsp. ruderalis Janish., ‘Finola’ is a dioecious cultivar of Finnish origin. This cultivar is very interesting because its cultivation cycle lasts less than 3 months. The aim of this study was to define an efficient micropropagation protocol to ensure in vitro multiplication and rooting and in vivo acclimatization. Two different explant sources were tested: seed-derived in vitro explants and nodal segments containing axillary buds from selected mother plants. Shoot proliferation was tested on different growth media enriched with cytokinin alone or cytokinin in combination with auxins. Among all combinations, the best results were obtained by combining the Basal Medium (BM—a Murashige and Skoog modified medium) with sucrose (20 g L−1), thidiazuron (TDZ 0.4 mg L−1), and 1-naphthalenacetic acid (NAA 0.2 mg L−1). Regarding rooting induction, the plants developed an extensive root system under red/blue lights on BM enriched with sucrose (30 g L−1) and indol-3 butyric acid (0.1 mg L−1), which allowed the survival of more than 90 percent of the plantlets once transplanted into the climate-controlled greenhouse.
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- 2023
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23. Lack of reactivation of tuberculosis in patients with psoriasis treated with secukinumab in a real-world setting of latent tuberculosis infection
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Matteo Megna, Cataldo Patruno, Maria Rita Bongiorno, Alessio Gambardella, Claudio Guarneri, Caterina Foti, Serena Lembo, Francesco Loconsole, and Gabriella Fabbrocini
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biologics ,chemoprophylaxis ,latent tuberculosis infection ,psoriasis ,reactivation ,secukinumab ,Dermatology ,RL1-803 - Abstract
Background Some biologics for psoriasis, especially anti-tumor necrosis factor (TNF)-α therapies, may re-activate latent tuberculosis (TBC) infection with consequent morbidity and mortality. However, there is a low reported incidence of conversion to positive TBC status among patients with psoriasis treated with second-generation biologic therapies, particularly anti-interleukin (IL)-17 therapies such as secukinumab. Objectives To evaluate the safety profile of secukinumab in psoriasis patients with latent TBC infection. Methods Real-life data were collected by retrospective chart review on patients with moderate-to-severe psoriasis who showed positivity for TBC screening at baseline and underwent secukinumab treatment for psoriasis at six Italian centers. Patients received secukinumab 300 mg at week 0/1/2/3/4, then every 4 weeks. Results Fifty-nine patients were enrolled; 30.5% also had psoriatic arthritis and other comorbidities were common. At baseline, the mean psoriasis duration was 14.5 years. Ten (17%) patients did not undergo prophylaxis before starting secukinumab. Conversely, isoniazid ± rifampicin or rifampicin alone prophylaxis was administered in 49/59 (83.1%) patients. After a mean treatment duration of 84 weeks, there were no cases of TBC reactivation and no unexpected safety signals. Conclusions Secukinumab use over an extended period was safe in psoriasis patients with latent TBC, even in patients who did not receive chemoprophylaxis.
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- 2022
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24. Unmet needs in atopic dermatitis management: an expert consensus
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Annalisa Patrizi, Antonio Costanzo, Cataldo Patruno, Valentina Maria Busà, Andrea Chiricozzi, and Giampiero Girolomoni
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atopic dermatitis ,management ,consensus ,delphi method ,Dermatology ,RL1-803 - Abstract
Introduction Atopic dermatitis (AD) has substantial negative impact on patients’ quality of life. Although considerable advances have been made in understanding the pathogenesis and its treatment, there is still limited transfer of this knowledge into daily management. Aiming to identify unmet needs in clinical management of patients with AD, we used a Delphi consensus process. Methods A set of statements regarding diagnosis, management, prognosis, and treatment was identified by five experts (Steering Committee). Then, the Steering Committee and a second group of four clinicians were involved in a Delphi process. Lastly, agreement was assessed in a larger panel of Italian clinicians. Results Overall, 37 clinicians participated to the process. 17 statements reached strong agreement and 2 reached weak agreement. Conclusions In general, the statements reflected the need for accurate and effective diagnostic criteria to support clinical experience, especially in the atypical forms of AD. Moreover, prognostic criteria are needed to predict the duration of adult-onset AD. The identification of biomarkers was considered to be useful for clinical management of AD at all stages of disease. Lastly, greater emphasis should be placed on patient education and development of effective tools that can aid informing patients about their disease and its treatment.
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- 2022
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25. Drug survival analysis of dupilumab and cyclosporin in patients with atopic dermatitis: a multicenter study
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Maddalena Napolitano, Maria Mariano, Antonio Cristaudo, Stefano Dastoli, Adriana Di Guida, Mario De Lucia, Gianluca Guerrasio, Steven Paul Nisticò, Maria Passante, Flavia Pigliacelli, Gabriella Fabbrocini, and Cataldo Patruno
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dupilumab ,cyclosporine ,drug survival ,immunosuppressive therapies ,safety ,Dermatology ,RL1-803 - Abstract
Purpose: This study provides a comparative survival analysis between the only two drugs approved in Italy for the treatment of moderate-to-severe AD, cyclospoorin, and dupilumab. Materials and methods: A multicenter, retrospective study, was performed to assess drug survival (DS) analysis by comparing cyclosporin (CsA) and dupilumab in 247 AD adult patients. DS was determined through Kaplan Meier survival analysis. For each patient, data regarding age, sex, medical history, and, at every visit, concomitant medications or procedures, adverse events (AEs), and Eczema Area and Severity Index (EASI) were registered. Results: At week 72, 32/247 patients (13.96%) of the dupilumab group had discontinued the drug after a mean time of treatment of 35.27 ± 11.61 weeks; therefore, the DS rate at W72 was 87.04%. The most frequent (13/32; 40.63%) reason of drug discontinuation was the achievement of complete disease remission after a mean duration of treatment of 42.28 ± 2.02 weeks. In CsA-treated patients, DS rate at W72 was 21.05% (20/95 patients). Sixty-seven out of 95 (70.53%) patients had discontinued the drug, while 8/95 (8.42%) of them were lost to follow-up during the first 12 weeks of treatment. The causes of withdrawal among the patients who stopped CsA were AEs (28/67;41.79%). Conclusions: Dupilumab has a significant longer DS when compared to CsA.
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- 2022
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26. The hidden sentinel of the skin: An overview on the role of interleukin-13 in atopic dermatitis
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Maddalena Napolitano, Francesca di Vico, Angelo Ruggiero, Gabriella Fabbrocini, and Cataldo Patruno
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atopic dermatitis (AD) ,interleukin-13 ,pathogenesis ,type 2 inflammation ,review ,Medicine (General) ,R5-920 - Abstract
Recent evidence suggests that interleukin (IL)-13 is a crucial cytokine involved in the pathogenesis of atopic dermatitis (AD). It is a central driver of type-2 T-helper inflammation and is overexpressed in lesional skin of AD patients. Upon release in peripheral skin, IL-13 activates its receptors, recruits inflammatory cells, and modifies the skin microbiome. IL-13 also reduces the expression of epidermal barrier proteins and activates sensory nerve mediating the itch transmission signal. Novel therapeutics that target IL-13 seem to be efficacious and safe for the treatment of patients with moderate-to-severe AD. The aim of our manuscript is to review the role that IL-13 plays in AD immunopathogenesis.
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- 2023
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27. Hippocampus guttulatus diet based on DNA metabarcoding
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Lazic Tamara, Bruno Fosso, Balech Bachir, Corriero Giuseppe, Gristina Michele, Marzano Marinella, Pesole Graziano, Santamaria Monica, and Cataldo Pierri
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seahorses ,Hippocampus guttulatus ,diet ,syngnathidae ,Mar Piccolo of Taranto ,DNA metabarcoding ,Science ,General. Including nature conservation, geographical distribution ,QH1-199.5 - Abstract
Seahorses are small sedentary fish considered flagship species of the conservation efforts. They are particularly vulnerable to human pressures because inhabiting threatened coastal ecosystems. Indeed, the worldwide decline of local populations in the last decades led to the inclusion of all seahorse species on the IUCN Red List, where most species, including Hippocampus guttulatus, were classified as ‘‘Data Deficient’’ on a global level due to the lack of relative data on several biological and ecological traits. Because of such sensitive conservation status, improvement of the current knowledge on the diet composition of wild animals and its differences among habitats could be of great importance as it could help understanding the way the environment is exploited. In the present study, we used a non-invasive DNA metabarcoding technique to further elucidate long-snouted seahorse diet and expand our understanding of prey choice among different habitats. We identified 24 families, 22 genera and 26 species, and according to the results, most of the seahorse samples contained taxa such as Amphipoda, Decapoda, Isopoda, and Mysida. Several non-native species were discovered in the diet, suggesting their dietary incorporation that could mirror high anthropogenic impacts and habitat modifications. We found significant differences in the diet composition among investigated habitats, thus indicating trophic flexibility of H. guttulatus among diverse habitats, a characteristic that may be essential for the resilience of this iconic yet sensitive species.
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- 2023
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28. Life-cycle traits in the demosponge Hymeniacidon perlevis in a land-based fish farm
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Maria Mercurio, Caterina Longo, Cataldo Pierri, Frine Cardone, Giuseppe Corriero, Tamara Lazic, Walter Zupa, and Pierluigi Carbonara
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Hymeniacidon perlevis ,Life-cycle ,Growth performances ,Lan-based fish farm ,Medicine ,Biology (General) ,QH301-705.5 - Abstract
Background The demosponge Hymeniacidon perlevis is characterized by wide geographic distribution and great adaptability to numerous and highly variable climatic and hydrological conditions. Indeed, the species can colonize many different environments, including several unusual ones, such as concrete drainage conduits of a marine land-based fish farm plant. This research aimed to enhance existing knowledge on the reproductive cycle and growth performance of H. perlevis while also evaluating the impact of a controlled supply of trophic resources, wastewater flow and constant water temperature on these biological traits. Methods Specimens included in this one-year study inhabited drainage conduits of a land-based fish farm. The approach included measurements of sponge biomass and occurrence and abundance of reproductive elements across different seasons and environmental parameters, such as fish biomass, trophic resources, and wastewater flow. Sponge growth and reproductive elements, including oocytes, spermatic cysts, and embryos, were measured monthly in sponges positioned in the drainage conduit, thus with different trophic resources but with constant water temperature. Finally, we used generalized additive models to describe variables that contribute the most to the growth of sponges. Results Growth performance showed marked variations during the study period. The highest increase in sponge volume was observed from August/September to January/March. The volume of sponges was principally determined by the reduction of reared fish biomass and the increase of pellet amount and wastewater flow. Sponge specimens exhibited an active state during the entire study, as proven by the occurrence of recruits. However, sexual elements were only sporadically observed, thus not permitting the recognition of a true sexual cycle. Discussion The results of the present study confirmed that H. perlevis exhibits high flexibility and adaptability to the differential, and somewhat extreme, environmental conditions. Indeed, this species can live, grow and reproduce in the drainage conduits of the fish farm, where the species face constant darkness, water temperature and continuous nutritional supply. In such conditions, H. perlevis display an active state during the entire year, while avoiding stages of decline and long dormancy usually observed in wild populations. It seems plausible that stable environmental conditions induce an almost continuous sexual phase, probably under the control of endogenous factors. No asexual elements were detected, although it was impossible to exclude the contribution of asexual reproduction in the origin of the newly settled sponges, which were repeatedly detected throughout the study. The growth performance seemed linked to the fish farm conditions, thus providing useful indications on the best maintenance conditions for H. perlevis in land-based integrated multitrophic systems, where the species could be used for wastewater treatment.
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- 2023
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29. Characteristics and Drug Utilization of Patients with Hereditary Angioedema in Italy, a Real-World Analysis
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Elisa Giacomini, Melania Leogrande, Valentina Perrone, Margherita Andretta, Marcello Bacca, Alessandro Chinellato, Andrea Ciaccia, Mariarosaria Cillo, Renato Lombardi, Daniela Mancini, Romina Pagliaro, Maurizio Pastorello, Cataldo Procacci, and Luca Degli Esposti
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HAE ,administrative databases ,danazol ,long-term prophylaxis ,Medicine - Abstract
This real-world analysis investigated the characteristics and treatment patterns of patients with hereditary angioedema (HAE) in Italy using the administrative data of health units across Italy. Patients were identified via exemption code or HAE-specific treatments (thus, all known forms, type I, II and, III, were included). The index date was that of first prescription of HAE treatments within the inclusion period (01/2010–06/2021) or of the date of exemption. The number of HAE patients included was 148 (43.2% male, mean age 43.3 years). Gastrointestinal disorders affected 36.5% patients, hypertension affected 28.4%, hypercholesterolemia affected 11.5%, and depression affected 9.5%. The frequent gastrointestinal involvement was further confirmed by the use of antiemetics and systemic antihistamines that doubled after the index date. Among patients enrolled by treatment (n = 125), n = 105 (84%) were receiving a treatment for acute attacks. This analysis provided insights into the characterization of patients with HAE and their management in Italian clinical practice, suggesting that an unmet therapeutic need could be present for such patients in terms of the clinical burden.
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- 2023
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30. Abundance, Distribution, and Habitat Preference of Syngnathid Species in Sabaudia Lake (Tyrrhenian Sea)
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Tamara Lazic, Cataldo Pierri, Giuseppe Corriero, Maria Flavia Gravina, Michele Gristina, Miriam Ravisato, and Armando Macali
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Syngnathidae ,pipefishes ,seahorses ,Mediterranean ,conservation ,Biology (General) ,QH301-705.5 - Abstract
Syngnathids are considered flagship species of estuarine and coastal environments. However, most of the Mediterranean species are still classified as data-deficient (DD) at a global level according to the IUCN Red List of Threatened Species. In central Italy, several areas host potentially suitable habitats for syngnathids but have not been previously reported in the literature; the estimation of population parameters and habitat partitioning at these sites may help to assess their conservation status. In this study, we investigated the abundance, distribution, and habitat preferences of sympatric populations of Hippocampus hippocampus, H. guttulatus, Syngnathus abaster, and Nerophis ophidion in Sabaudia Lake (Tyrrhenian Sea, Italy). While confirming the primary importance of a healthy coastal habitat, we retrieved hints about species ecology and habitat use. The species distribution in the study area highlights the role of habitat complexity in supporting local populations of these sensitive species.
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- 2023
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31. Safety evaluation of Datopotamab deruxtecan for triple-negative breast cancer: a meta-analysis
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Gennaro Gadaleta-Caldarola, Laura Lanotte, Stefania Infusino, Arianna Gadaleta-Caldarola, Francesca Matilde Schipilliti, Claudia Citrigno, Cataldo Petrarota, Antonio Cusmai, and Alessandro Rizzo
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Breast cancer ,Triple-negative breast cancer ,Antibody drug conjugates ,Datopotamab deruxtecan ,Dato-Dxd ,Neoplasms. Tumors. Oncology. Including cancer and carcinogens ,RC254-282 - Abstract
Background: TROP-2 is emerging as a valid and fruitful strategy in triple-negative breast cancer (TNBC) patients, and several agents are currently under evaluation, including Datopotamab deruxtecan (Dato-DXd). Research design and methods: Herein, we performed a meta-analysis aimed to evaluate any grade adverse events, grade 3-4 adverse events, dose reduction, and serious adverse events in TNBC patients treated with Dato-DXd in clinical trials. Results: The pooled results suggests that Dato-DXd is associated with a favorable safety profile: while any grade treatment-related toxicities were common, grade 3-4 events were not particularly frequent and mainly represented by stomatitis (13.88%; 95% CI, 10.68 – 17.09). Conclusions: These findings may help to comprehensively define the safety profile of Dato-DXd and to assist in the design of future clinical trials in this setting.
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- 2023
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32. Quality of life in patients with allergic and immunologic skin diseases: in the eye of the beholder
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Ester Di Agosta, Lorenzo Salvati, Monica Corazza, Ilaria Baiardini, Francesca Ambrogio, Luisa Angileri, Elettra Antonelli, Federica Belluzzo, Domenico Bonamonte, Laura Bonzano, Raffaele Brancaccio, Paolo Custurone, Aurora De Marco, Aikaterini Detoraki, Adriana Di Guida, Elisabetta Di Leo, Marta Fantò, Filippo Fassio, Silvia Mariel Ferrucci, Caterina Foti, Rosella Gallo, Alessia Gatta, Fabrizio Guarneri, Lucia Guidolin, Katharina Hansel, Donatella Lamacchia, Carla Lombardo, Paola Lucia Minciullo, Maddalena Napolitano, Alessandro Pannofino, Andrea Paravisi, Roberta Parente, Maria Passante, Cataldo Patruno, Diego Peroni, Cristina Quecchia, Natale Schettini, Giuseppe Spadaro, Luca Stingeni, Daniele Tarrini, Marta Tramontana, Eustachio Nettis, and Oliviero Rossi
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Quality of life ,Atopic dermatitis ,Allergic contact dermatitis ,Hereditary angioedema ,Cutaneous mastocytosis ,Urticaria ,Immunologic diseases. Allergy ,RC581-607 - Abstract
Abstract Allergic and immunologic skin diseases negatively impact the quality of life (QoL) of affected patients with detrimental consequences. Nonetheless, in everyday clinical practice the evaluation of QoL is often overlooked. Considering the increasing prevalence of atopic dermatitis, allergic contact dermatitis, hereditary angioedema, cutaneous mastocytosis, and urticaria, it is essential to determine the effects of allergic and immunologic skin diseases on QoL. A joint meeting (GET TOGETHER 2021) of the Italian Society of Allergology, Asthma and Clinical Immunology (SIAAIC) and the Italian Society of Allergological, Occupational and Environmental Dermatology (SIDAPA) aimed to summarize the features of the main QoL tools used in these diseases and to describe the extent of QoL impairment as well as the impact of treatments on QoL, particularly biologic therapies. The assessment of QoL in patients with allergic and immunologic skin diseases relies on generic, organ-specific and disease-specific questionnaires. While generic and organ-specific questionnaires allow comparison between different diseases, disease-specific questionnaires are designed and validated for specific cohorts: the QoL Index for Atopic Dermatitis (QoLIAD) and the Childhood Atopic Dermatitis Impact Scale (CADIS) in atopic dermatitis, the ACD-11 in allergic contact dermatitis, the Angioedema QoL Questionnaire (AE-QoL) and the Hereditary Angioedema QoL questionnaire (HAE-QoL) in hereditary angioedema, the Mastocytosis QoL Questionnaires (MCQoL e MQLQ) in cutaneous mastocytosis, and the Chronic Urticaria QoL questionnaire (CU-Q2oL) in urticaria. Among the many factors that variably contribute to QoL impairment, pruritus can represent the leading cause of patient discomfort. Biologic therapies significantly ameliorate QoL in atopic dermatitis, hereditary angioedema, mastocytosis and chronic urticaria. In general, adequate management strategies are essential for improving QoL in patients with allergic and immunologic skin diseases.
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- 2021
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33. Nanosecond Q-Switched 1064/532 nm Laser to Treat Hyperpigmentations: A Double Center Retrospective Study
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Steven Paul Nisticò, Giovanni Cannarozzo, Eugenio Provenzano, Federica Tamburi, Gilda Fazia, Mario Sannino, Francesca Negosanti, Ester Del Duca, Cataldo Patruno, and Luigi Bennardo
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Q switched laser ,benign hyperpigmentations ,melasma ,solar lentigo ,Medicine (General) ,R5-920 - Abstract
(1) Benign hyperpigmentations are a common problem in cosmetic dermatology. Melasma, solar lentigo, and other acquired hyperpigmentations represent an aesthetic issue for an increasing number of patients. The gold standard in managing this condition is currently 1064/532 nanometers (nm) Q-Switched lasers. This study reports our experience on the use of a Q-switched laser with a nanosecond pulse to treat these conditions. (2) Methods: A total of 96 patients asking for benign hyperpigmentation removal were consecutively enrolled at the Magna Graecia University of Catanzaro and Tor Vergata University of Rome. Treating parameters were the following: 1064 nm with a pulse duration of 6 nanoseconds (ns) for dermic lesions and 532 nm with 6 ns for epidermal ones. Up to five treatments with a minimum interval between laser treatments of thirty days were performed. A follow-up visit three months after the last session assessed patient satisfaction with a Visual Analogue Scale (VAS). Two blinded dermatologists assessed the cosmetic result using a five-point scale comparing pictures before treatment and at follow-up. (3) Results: 96 patients were included; 47 participants were women (49.0%) and 49 men (51.0%). The mean reported age was 50.0 ± 17.3 years. All patients reached a good to complete hyperpigmentation removal at the dermatological evaluation with a mean VAS score of 8.91 ± 1.07. (4) Conclusions: Q Switched 1064/532 nm laser may be considered the gold standard treatment for benign hyperpigmentations. Our results confirm the literature findings on the effectiveness of these devices.
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- 2021
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34. VARADE: a Variational-based AutoRegressive model for Anomaly Detection on the Edge
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Mascolini, Alessio, Gaiardelli, Sebastiano, Ponzio, Francesco, Dall'Ora, Nicola, Macii, Enrico, Vinco, Sara, Di Cataldo, Santa, and Fummi, Franco
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Computer Science - Machine Learning ,Computer Science - Artificial Intelligence - Abstract
Detecting complex anomalies on massive amounts of data is a crucial task in Industry 4.0, best addressed by deep learning. However, available solutions are computationally demanding, requiring cloud architectures prone to latency and bandwidth issues. This work presents VARADE, a novel solution implementing a light autoregressive framework based on variational inference, which is best suited for real-time execution on the edge. The proposed approach was validated on a robotic arm, part of a pilot production line, and compared with several state-of-the-art algorithms, obtaining the best trade-off between anomaly detection accuracy, power consumption and inference frequency on two different edge platforms.
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- 2024
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35. Superfluid-tight cryogenic receiver with continuous sub-Kelvin cooling for EXCLAIM
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Dahal, Sumit, Ade, Peter A. R., Anderson, Christopher J., Barlis, Alyssa, Barrentine, Emily M., Beeman, Jeffrey W., Bellis, Nicholas, Bolatto, Alberto D., Braianova, Victoria, Breysse, Patrick C., Bulcha, Berhanu T., Cataldo, Giuseppe, Colazo, Felipe A., Chevres-Fernandez, Lee-Roger, Cho, Chullhee, Chmaytelli, Danny S., Connors, Jake A., Costen, Nicholas P., Cursey, Paul W., Ehsan, Negar, Essinger-Hileman, Thomas M., Glenn, Jason, Golec, Joseph E., Hays-Wehle, James P., Hess, Larry A., Jahromi, Amir E., Jenkins, Trevian, Kimball, Mark O., Kogut, Alan J., Kramer, Samuel H., Leung, Nicole, Lowe, Luke N., Mauskopf, Philip D., McMahon, Jeffrey J., Mikula, Vilem, Mirzaei, Mona, Moseley, Samuel H., Mugge-Durum, Jonas W., Nellis, Jacob, Noroozian, Omid, Okun, Kate, Oxholm, Trevor, Parekh, Tatsat, Pen, Ue-Li, Pullen, Anthony R., Rahmani, Maryam, Ramirez, Mathias M., Roberson, Cody, Rodriguez, Samelys, Roselli, Florian, Sapkota, Deepak, Shire, Konrad, Siebert, Gage L., Siddique, Faizah, Sinclair, Adrian K., Somerville, Rachel S., Stephenson, Ryan, Stevenson, Thomas R., Switzer, Eric R., Termini, Jared, Timbie, Peter T., Trenkamp, Justin, Tucker, Carole E., Visbal, Elijah, Volpert, Carolyn G., Watson, Joseph, Weeks, Eric, Wollack, Edward J., Yang, Shengqi, and Yung, Aaron
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Astrophysics - Instrumentation and Methods for Astrophysics - Abstract
The EXperiment for Cryogenic Large-Aperture Intensity Mapping (EXCLAIM) is a balloon-borne telescope designed to survey star formation over cosmological time scales using intensity mapping in the 420 - 540 GHz frequency range. EXCLAIM uses a fully cryogenic telescope coupled to six on-chip spectrometers featuring kinetic inductance detectors (KIDs) to achieve high sensitivity, allowing for fast integration in dark atmospheric windows. The telescope receiver is cooled to $\approx$ 1.7 K by immersion in a superfluid helium bath and enclosed in a superfluid-tight shell with a meta-material anti-reflection coated silicon window. In addition to the optics and the spectrometer package, the receiver contains the magnetic shielding, the cryogenic segment of the spectrometer readout, and the sub-Kelvin cooling system. A three-stage continuous adiabatic demagnetization refrigerator (CADR) keeps the detectors at 100 mK while a $^4$He sorption cooler provides a 900 mK thermal intercept for mechanical suspensions and coaxial cables. We present the design of the EXCLAIM receiver and report on the flight-like testing of major receiver components, including the superfluid-tight receiver window and the sub-Kelvin coolers., Comment: 13 pages, 7 figures, 1 table
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- 2024
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36. Closing in on possible scenarios for infinite-layer nickelates: comparison of dynamical mean-field theory with angular-resolved photoemission spectroscopy
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Si, Liang, Jacob, Eric, Wu, Wenfeng, Hausoel, Andreas, Krsnik, Juraj, Worm, Paul, Di Cataldo, Simone, Janson, Oleg, and Held, Karsten
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Condensed Matter - Superconductivity ,Condensed Matter - Materials Science ,Condensed Matter - Strongly Correlated Electrons - Abstract
Conflicting theoretical scenarios for infinite-layer nickelate superconductors have been hotly debated, particularly regarding whether {only} a single Ni-3$d_{x^2-y^2}$ band is relevant at low energies besides electron pockets or whether multi-orbital physics including Ni-3$d_{z^2}$ is instead essential. The first scenario has emerged from density-functional theory plus dynamical mean-field theory (DFT+DMFT) calculations. Comparing the previous DFT+DMFT spectra to recent angular-resolved photoemission spectroscopy (ARPES) experiments, we find excellent agreement for both the Fermi surface and the strongly renormalized quasi-particle bands, supporting the first scenario. Our key findings further suggest that the "waterfalls" observed in ARPES might emerge from the quasi-particle--to--Hubbard-band crossover, and that additional spectral weight close to the $A$-pocket likely originates from the Ni-3$d_{xy}$ orbital., Comment: 8 pages, 4 figures
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- 2024
37. Bayesian Uncertainty Quantification and Reliability Assessment for Mars Sample Return
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Sanderson, Dawn L., Braverman, Amy, Cataldo, Giuseppe, Smith, Ralph C., and Smith, Richard L.
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Statistics - Applications - Abstract
In this paper, we employ a Bayesian approach to assess the reliability of a critical component in the Mars Sample Return program, focusing on the Earth Entry System's risk of containment not assured upon reentry. Our study uses Gaussian Process modeling under a Bayesian regime to analyze the Earth Entry System's resilience against operational stress. This Bayesian framework allows for a detailed probabilistic evaluation of the risk of containment not assured, indicating the feasibility of meeting the mission's stringent safety goal of 0.999999 probability of success. The findings underscore the effectiveness of Bayesian methods for complex uncertainty quantification analyses of computer simulations, providing valuable insights for computational reliability analysis in a risk-averse setting.
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- 2024
38. A system of marine animal bioconstructions in the mesophotic zone along the Southeastern Italian coast
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Frine Cardone, Giuseppe Corriero, Caterina Longo, Cataldo Pierri, Guadalupe Gimenez, Maria Flavia Gravina, Adriana Giangrande, Stefania Lisco, Massimo Moretti, Francesco De Giosa, Maria Mercurio, and Carlotta Nonnis Marzano
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marine bioconstructions ,mesophotic zone ,macrobenthic taxa ,central Mediterranean Sea ,Ostreida ,Scleractinia ,Science ,General. Including nature conservation, geographical distribution ,QH1-199.5 - Abstract
A widespread and diversified mesophotic system of carbonate bioconstructions along the Southern Adriatic and Ionian Italian coasts is described, providing new data on the distribution, structure and associated megabenthic assemblages of mesophotic Mediterranean bioconstructions. The bioconstructions were detected at six different sites off the coasts of Apulia, in presence of marked morphological escarpments, developing on a basal substrate consisting of meso-Cenozoic carbonate rocks. Two biogenic structure types were observed, one mainly built by the nonsymbiotic scleractinians Phyllangia americana mouchezii and Polycyathus muellerae, at depths between approximately 35 and 55 m, and the other by the oyster Neopycnodonte cochlear, at depths from approximately 40 to 70 m. A total of 52 taxa of megabenthic invertebrates, belonging to 6 phyla, were found on the surface of the mesophotic bioconstructions, thus confirming the role of biodiversity hotspots of these carbonate structures. Megabenthic assemblages showed a remarkable heterogeneity both in pattern of species and abundance, probably depending on both the morphological differences of the seabed and the life traits of the single species. Primary bioconstructors seemed to influence the associated community pattern. This peculiar system deserves sound conservation measures in the light of the holistic ecosystem approach for the management of coastal marine areas.
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- 2022
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39. New Perspectives in Sustainable Aquaculture
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Caterina Longo and Cataldo Pierri
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n/a ,Naval architecture. Shipbuilding. Marine engineering ,VM1-989 ,Oceanography ,GC1-1581 - Abstract
The strong growth of the aquaculture industry can represent a serious threat to aquatic ecosystems and requires the development of new strategies to control and minimize the impact of such activities on the structure and function of biological communities [...]
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- 2023
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40. Variability in Productive and Biochemical Traits of Vicia faba L. Landraces from Apulia Region (South Italy)
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Francesca De Cillis, Claudia Ruta, Cataldo Pulvento, Luigi Tedone, and Giuseppe De Mastro
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faba bean ,landraces ,grain production ,proteins ,total phenols ,total flavonoids ,Plant culture ,SB1-1110 - Abstract
The faba bean (Vicia faba L. var. major) is a pulse that is garnering attention for its chemical composition, which makes it suitable for a healthy diet. The Apulian germplasm is rich in local accessions at risk of genetic erosion, which need evaluating and promoting. Thirteen Vicia faba local Landraces have been analyzed in relation to their productivity and their chemical and biochemical characteristics: their protein, total phenol, total flavonoid, condensate tannin and L-DOPA levels. The results showed great variability—above all in the thousand-seeds weight and in their content of proteins and L-DOPA. Among the accessions evaluated, the two collected from the most southern area of the region (FV12-FV10) were particularly promising—both for their good biochemical traits and, especially, for the higher L-DOPA content (0.46 and 0.49 g 100 g−1 d.m., respectively), even when expressed in terms of yield per plant (116.3 and 153.0 mg plant−1 d.m., respectively).
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- 2023
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41. Local Chemotherapy as an Adjuvant Treatment in Unresectable Squamous Cell Carcinoma: What Do We Know So Far?
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Luigi Bennardo, Francesco Bennardo, Amerigo Giudice, Maria Passante, Stefano Dastoli, Pietro Morrone, Eugenio Provenzano, Cataldo Patruno, and Steven Paul Nisticò
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squamous cell carcinoma ,imiquimod ,5-fluorouracil ,Neoplasms. Tumors. Oncology. Including cancer and carcinogens ,RC254-282 - Abstract
Background: Squamous cell carcinoma (SCC) is one of the most common cancers involving skin and oral mucosa. Although this condition’s gold-standard treatment is the surgical removal of the lesions, the physician must propose alternative treatments in some cases due to the patient’s ineligibility for surgery. Among the available alternative therapies, local chemotherapy may represent an initial treatment in combination with radiotherapy or systemic chemotherapy due to the low frequency of side-effects and the lack of necessity for expensive devices. Methods: In this paper, we review all available literature in various databases (PubMed, Scopus-Embase, Web of Science), proposing local chemotherapy as a treatment for cutaneous and oral SCC. Exclusion criteria included ocular lesions (where topical treatments are common), non-English language, and non-human studies. Results: We included 14 studies in this review. The majority were case reports and case series describing the treatment of non-resectable localized SCC with either imiquimod or 5-fluorouracil. We also analyzed small studies proposing combination treatments. Almost all studies reported an excellent clinical outcome, with a low risk of relapses in time. Conclusions: Resection of the lesion remains the gold-standard treatment for SCC. When this approach is not feasible, local chemotherapy may represent a treatment alternative, and it may also be associated with radiotherapy or systemic chemotherapy.
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- 2021
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42. Microbial and Qualitative Traits of Quinoa and Amaranth Seeds from Experimental Fields in Southern Italy
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Anna Reale, Maria Cristina Messia, Cataldo Pulvento, Antonella Lavini, Stefania Nazzaro, and Tiziana Di Renzo
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pseudocereals ,spore-forming bacteria ,Bacillus spp. ,PCR-DGGE ,rope spoilage ,bread ,Chemical technology ,TP1-1185 - Abstract
Quinoa and amaranth are of special interest since they are increasingly used for the development of new bakery products with enhanced nutritional value. The aim of the study was to evaluate the agronomic, microbiological, and nutritional characteristics of quinoa and amaranth seeds grown in Southern Italy. For this reason, quinoa Titicaca and three amaranth accessions (5, 12, and 14) were cultivated in different experimental fields in the Campania Region and analyzed for the cultivation aspects, chemical composition, and microbiological quality of the seeds. All seeds showed a good adaptability to cultivation in the experimental areas of the Mediterranean basin. Quinoa seeds were characterized by their higher protein, fat, and ash content than the amaranth seeds, which were characterized by their higher value in dietary fiber. All seeds, regardless of the geographical area of production, were contaminated with yeasts, moulds, and spore-forming bacteria, mainly Bacillus cereus, B. licheniformis, B. safensis and B. subtilis, as identified by 16S rRNA sequencing analysis. So, the detection of Bacillus spp. must be strongly monitored, as quinoa and amaranth seeds could be used in bread production, where they can cause ropiness, resulting in great economic losses for the industries.
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- 2023
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43. The Use of JAK/STAT Inhibitors in Chronic Inflammatory Disorders
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Giuseppina Caiazzo, Anna Caiazzo, Maddalena Napolitano, Matteo Megna, Luca Potestio, Luigi Fornaro, Melania Parisi, Maria Antonietta Luciano, Angelo Ruggiero, Anna Testa, Fabiana Castiglione, Cataldo Patruno, Maria Quaranta, and Gabriella Fabbrocini
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JAK/STAT signaling pathway ,JAK-STAT inhibitors ,inflammatory disorders ,atopic dermatitis ,psoriasis ,psoriatic arthritis ,Medicine - Abstract
The Janus kinase (JAK)-signal transducer and activator of transcription (STAT) pathway plays a critical role in orchestrating immune and inflammatory responses, and it is essential for a wide range of cellular processes, including differentiation, cell growth, and apoptosis. Over the years, this pathway has been heavily investigated due to its key role in the pathogeneses of several chronic inflammatory conditions, e.g., psoriasis, atopic dermatitis (AD), and inflammatory bowel diseases (IBDs). Nevertheless, the impact of this pathway on the pathogenesis of inflammatory conditions remains unclear. This review describes the role of the JAK/STAT signaling pathway in the pathogenesis of inflammatory diseases such as psoriasis (Pso), psoriatic arthritis (PsA), AD, and IBD with a focus on ulcerative colitis (UC) and briefly resumes the use of JAK inhibitors in their clinical management.
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- 2023
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44. Worldwide Evaluations of Quinoa—Biodiversity and Food Security under Climate Change Pressures: Advances and Perspectives
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Cataldo Pulvento and Didier Bazile
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n/a ,Botany ,QK1-989 - Abstract
Quinoa (Chenopodium quinoa Willd [...]
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- 2023
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45. Letter to the editor submitted in response to ‘Incidence and prognosis of COVID-19 in patients with atopic diseases on dupilumab: a multicentre retrospective cohort study’
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Maddalena Napolitano, Luca Potestio, Francesca Di Vico, Gabriella Fabbrocini, and Cataldo Patruno
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Dermatology ,RL1-803 - Published
- 2022
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46. Biofouling Role in Mariculture Environment Restoration: An Example in the Mar Grande of Taranto (Mediterranean Sea)
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Daniele Arduini, Jacopo Borghese, Maria Flavia Gravina, Roberta Trani, Caterina Longo, Cataldo Pierri, and Adriana Giangrande
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biodiversity ,artificial hard substrates ,mariculture ,fouling ,macrobenthic invertebrates ,Mediterranean Sea ,Science ,General. Including nature conservation, geographical distribution ,QH1-199.5 - Abstract
The biodiversity of macrobenthic invertebrates of two artificial hard substrates close to a mariculture plant was assessed in order to understand the effect on the fouling community of an innovative Integrated Multi-Trophic Aquaculture (IMTA) system. The examined hard substrates were (i) vertical bare collectors that are placed around the cages as new colonizable substrates, which were investigated from the early colonization and (ii) artificial hard substrates already present under the cages analyzed over time to observe changes due to the action on the water column by filter feeder organisms colonizing the above vertical collectors. Overall, 186 taxa were collected (both the substrates), of which 99 as sessile habitat-former or structuring macroinvertebrates and 87 as associated fauna, mostly vagile forms. On the vertical collectors 121 taxa were collected, among which 44 sessile structuring species and 77 vagile-associated taxa; on the artificial hard substrates under the cages, 124 taxa were identified, 95 belong to the first category and 29 as associated taxa. The two analyzed substrates shared 43% of sessile species (40) and 22% of associated species (19). At the end of the first year of experimentation, the study revealed Sabella spallanzanii and mussels as the most abundant taxa. Lastly, the communities under the cages showed an increase in biodiversity after the placement of collectors. The changes were attributed to the decrease in particulate matter originating as wastes from the breeding cage, which was intercepted by the filter feeder community developed on the vertical collectors.
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- 2022
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47. Giant splitting of the hydrogen rotational eigenenergies in the C$_2$ filled ice
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Di Cataldo, Simone, Rescigno, Maria, Monacelli, Lorenzo, Ranieri, Umbertoluca, Gaal, Richard, Klotz, Stefan, Ollivier, Jacques, Koza, Michael Marek, De Michele, Cristiano, and Bove, Livia Eleonora
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Condensed Matter - Soft Condensed Matter ,Quantum Physics - Abstract
Hydrogen hydrates present a rich phase diagram influenced by both pressure and temperature, with the so-called C$_2$ phase emerging prominently above 2.5 GPa. In this phase, hydrogen molecules are densely packed within a cubic ice-like lattice and the interaction with the surrounding water molecules profoundly affects their quantum rotational dynamics. Herein, we delve into this intricate interplay by directly solving the Schr\"{o}dinger's equation for a quantum H$_2$ rotor in the C$_2$ crystal field at finite temperature, generated through Density Functional Theory. Our calculations reveal a giant energy splitting relative to the magnetic quantum number of $\pm$3.2 meV for $l=1$. Employing inelastic neutron scattering, we experimentally measure the energy levels of H$_2$ within the C$_2$ phase at 6.0 and 3.4 GPa and low temperatures, finding remarkable agreement with our theoretical predictions. These findings underscore the pivotal role of hydrogen--water interactions in dictating the rotational behavior of the hydrogen molecules within the C$_2$ phase and indicate heightened induced-dipole interactions compared to other hydrogen hydrates., Comment: 4 Figures
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- 2024
48. A Formal Model of Security Controls' Capabilities and Its Applications to Policy Refinement and Incident Management
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Basile, Cataldo, Gatti, Gabriele, and Settanni, Francesco
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Computer Science - Cryptography and Security - Abstract
Enforcing security requirements in networked information systems relies on security controls to mitigate the risks from increasingly dangerous threats. Configuring security controls is challenging; even nowadays, administrators must perform it without adequate tool support. Hence, this process is plagued by errors that translate to insecure postures, security incidents, and a lack of promptness in answering threats. This paper presents the Security Capability Model (SCM), a formal model that abstracts the features that security controls offer for enforcing security policies, which includes an Information Model that depicts the basic concepts related to rules (i.e., conditions, actions, events) and policies (i.e., conditions' evaluation, resolution strategies, default actions), and a Data Model that covers the capabilities needed to describe different types of filtering and channel protection controls. Following state-of-the-art design patterns, the model allows for generating abstract versions of the security controls' languages and a model-driven approach for translating abstract policies into device-specific configuration settings. By validating its effectiveness in real-world scenarios, we show that SCM enables the automation of different and complex security tasks, i.e., accurate and granular security control comparison, policy refinement, and incident response. Lastly, we present opportunities for extensions and integration with other frameworks and models.
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- 2024
49. Sponges from rhodolith beds surrounding Ustica Island marine protected area (southern Tyrrhenian Sea), with a comprehensive inventory of the island sponge fauna
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Caterina Longo, Giuseppe Corriero, Frine Cardone, Maria Mercurio, Cataldo Pierri, and Carlotta Nonnis Marzano
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porifera ,ustica island ,mediterranean sea ,rhodolith beds ,coralligenous formations ,photophilous hard substrates ,marine caves ,Aquaculture. Fisheries. Angling ,SH1-691 - Abstract
The sponge fauna colonizing rhodolith beds from Ustica Island marine protected area was studied. Moreover, an inventory of the sponge species present along the island’s coasts was carried out for the first time. Analysis of rhodoliths trapped in nets used by local fishermen at two sites and data obtained from underwater video images were used to identify 25 sponge taxa, 22 of them at species level. The classes Demospongiae and Homoscleromorpha were present with 24 and 1 species, respectively. Most of the specimens were small-sized and represented by thick crusts or short erect branches. Few specimens were insinuating or excavating. Furthermore, qualitative sampling was performed on Ustica’s coralligenous formations, photophilous hard substrates and in marine caves, and the results obtained were added to the literature data. The overall checklist of sponges from Ustica encompassed 97 taxa, 90 named at species level, subdivided into 6 taxa of Calcarea, 3 of Homoscleromorpha and 88 of Demospongiae. Eleven of the species were endemic to the Mediterranean Sea, mainly concentrated on rhodoliths and in marine caves. This research adds a fundamental element to the knowledge of invertebrates associated with rhodoliths, and updates the checklist of sponges colonizing Ustica’s waters, facilitating its future monitoring.
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- 2020
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50. Urticaria: recommendations from the Italian Society of Allergology, Asthma and Clinical Immunology and the Italian Society of Allergological, Occupational and Environmental Dermatology
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Eustachio Nettis, Caterina Foti, Marina Ambrifi, Ilaria Baiardini, Leonardo Bianchi, Alessandro Borghi, Marco Caminati, Giorgio Walter Canonica, Marco Casciaro, Laura Colli, Giselda Colombo, Monica Corazza, Antonio Cristaudo, Giulia De Feo, Ornella De Pita’, Mario Di Gioacchino, Elisabetta Di Leo, Filippo Fassio, Sebastiano Gangemi, Alessia Gatta, Katharina Hansel, Enrico Heffler, Cristoforo Incorvaia, Maddalena Napolitano, Cataldo Patruno, Silvia Peveri, Paolo Daniele Pigatto, Cristina Quecchia, Anna Radice, Giuseppe Alvise Ramirez, Paolo Romita, Franco Rongioletti, Oliviero Rossi, Eleonora Savi, Gianenrico Senna, Massimo Triggiani, Myriam Zucca, Enrico Maggi, and Luca Stingeni
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Acute urticaria ,Chronic urticaria ,Angioedema ,Guidelines ,Antihistamines ,Corticosteroids ,Immunologic diseases. Allergy ,RC581-607 - Abstract
Abstract Background Urticaria is a disorder affecting skin and mucosal tissues characterized by the occurrence of wheals, angioedema or both, the latter defining the urticaria-angioedema syndrome. It is estimated that 12–22% of the general population has suffered at least one subtype of urticaria during life, but only a small percentage (estimated at 7.6–16%) has acute urticaria, because it is usually self-limited and resolves spontaneously without requiring medical attention. This makes likely that its incidence is underestimated. The epidemiological data currently available on chronic urticaria in many cases are deeply discordant and not univocal, but a recent Italian study, based on the consultation of a national registry, reports a prevalence of chronic spontaneous urticaria of 0.02% to 0.4% and an incidence of 0.1–1.5 cases/1000 inhabitants/year. Methods We reviewed the recent international guidelines about urticaria and we described a methodologic approach based on classification, pathophysiology, impact on quality of life, diagnosis and prognosis, differential diagnosis and management of all the types of urticaria. Conclusions The aim of the present document from the Italian Society of Allergology, Asthma and Clinical Immunology (SIAAIC) and the Italian Society of Allergological, Occupational and Environmental Dermatology (SIDAPA) is to provide updated information to all physicians involved in diagnosis and management of urticaria and angioedema.
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- 2020
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