4 results on '"C. Pfohl"'
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2. Intracranial Toxoplasma gondii granuloma in a cat
- Author
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Jessica C. Pfohl and Curtis W. Dewey
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Male ,0301 basic medicine ,Pathology ,medicine.medical_specialty ,040301 veterinary sciences ,Cat Diseases ,Serology ,0403 veterinary science ,03 medical and health sciences ,parasitic diseases ,medicine ,Animals ,Small Animals ,Granuloma ,medicine.diagnostic_test ,biology ,Toxoplasma gondii ,Clindamycin ,Magnetic resonance imaging ,04 agricultural and veterinary sciences ,medicine.disease ,biology.organism_classification ,Magnetic Resonance Imaging ,Toxoplasmosis ,Toxoplasmosis, Animal ,030104 developmental biology ,Toxoplasmosis, Cerebral ,Cats ,Phenobarbital ,Differential diagnosis ,Toxoplasma ,medicine.drug - Abstract
An 8-year-old cat with recent-onset generalized seizures was diagnosed with a right forebrain mass using magnetic resonance imaging. The mass was excised and upon histologic and immunohistochemical examination shown to be a Toxoplasma gondii granuloma. Serology supported active T gondii infection. The cat was treated with phenobarbital to control seizures. After definitive diagnosis of toxoplasma granuloma, clindamycin was administered for approximately 1 month. Seizures recurred 8 months after initial presentation, and the cat was euthanased at the owner's request. This is a previously unreported manifestation of feline central nervous system toxoplasmosis. When a mass lesion is present in the brain of a cat and serologic test results support active infection with T gondii, toxoplasma granuloma must be a differential diagnosis. If the patient is suffering from clinical disease, surgical resection of the mass (if possible) can be complimented with medical treatment until definitive diagnosis is obtained. Immunocompromising factors should be identified and addressed if possible.
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- 2005
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3. Deposition of Boron Containing Coatings Using MO-PACVD Process to Protect Aluminium Casting Tools
- Author
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A. Gebauer, C. Pfohl, and K.-T. Rie
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010302 applied physics ,Materials science ,Scanning electron microscope ,Plasma parameters ,Metallurgy ,General Physics and Astronomy ,chemistry.chemical_element ,02 engineering and technology ,engineering.material ,021001 nanoscience & nanotechnology ,Microstructure ,01 natural sciences ,Die casting ,chemistry ,Coating ,Chemical engineering ,Aluminium ,[PHYS.HIST]Physics [physics]/Physics archives ,0103 physical sciences ,engineering ,0210 nano-technology ,Tin ,Layer (electronics) - Abstract
In this paper the synthesis of (B,C,N), Zr(B,C) and Zr(B,C,N) layers is investigated by means of DC pulsed plasma assisted CVD using organic compounds as precursors. The process parameters such as coating temperature, gas pressure, gas mixture, plasma parameters are varied to deposit functional coatings on hot-work steel used in the aluminium die casting industry. One of the objectives is to realize a layer type which withstands the severe service conditions in aluminium die casting. Another objective is to lower the coating temperature. The layers have been studied by light- and scanning electron microscopy (SEM). The properties of the deposited layers are determined by various analytical methods such as WDS-analysis for the chemical composition and X-ray diffraction (XRD) for the morphology. The hardness and adhesion of the layers were measured to determine the mechanical properties. The adhesion to liquid aluminium is investigated and compared to TiN layers deposited with TiCl 4 as precursor.
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- 1995
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4. BNP and NT-proBNP Thresholds for the Assessment of Prognosis in Patients Without Heart Failure.
- Author
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Jehn S, Mahabadi AA, Pfohl C, Vogel L, Al-Rashid F, Luedike P, Totzeck M, Rassaf T, and Dykun I
- Abstract
Background: Brain natriuretic peptide (BNP)/N-terminal-pro hormone brain natriuretic peptides (NT-proBNP) enable risk stratification, diagnosing, and monitoring of heart failure patients. An additional prognostic value for BNP/NT-proBNP in nonheart failure patients and general population cohorts is described in the literature, but specific cut-off levels are only described for heart failure patients., Objectives: This study aimed to determine thresholds for risk stratification in nonheart failure patients., Methods: Based on the Essen Coronary Artery Disease registry we excluded patients with known heart failure or elevated BNP/NT-pro BNP levels. The resulting cohort was divided into a derivation and validation cohort using random sampling. The prognostic value of BNP/NT-proBNP of incident mortality was evaluated in the derivation cohort using univariate and multivariable cox regression analysis. In receiver operating characteristic analysis and corresponding area under the curve the optimal threshold was determined using Youdens J index. The findings were verified in the validation cohort., Results: A total of 3,690 patients (age 62.9 ± 12.5 years, 71% male, 68% patients with coronary artery disease) were included. During a mean follow-up of 2.6 ± 3.4 years (median 1.2 [IQR: 0.4-2.88]), 169 deaths of any cause occurred. Based on Youden's J index, BNP-thresholds of 9.6 and 29pg/ml and NT-proBNP thresholds of 65 and 77pg/ml for men and women, respectively, were determined. BNP/NT-proBNP levels above these thresholds were associated with increased mortality in the derivation cohort (HR: 2.44 [95% CI: 1.32-4.53], P = 0.005). The predictive value was confirmed in the validation cohort (HR: 2.78 [95% CI: 1.26-6.14], P = 0.01)., Conclusions: We here describe sex-specific BNP/NT-proBNP thresholds that allow prediction of impaired survival in patients without heart failure, independent of traditional cardiovascular risk factors., Competing Interests: Dr Jehn was supported as a Junior Clinician Scientist within the University Medicine Essen Academy (UMEA) funded by the Faculty of Medicine, 10.13039/501100008349University of Duisburg-Essen. All other authors have reported that they have no relationships relevant to the contents of this paper to disclose., (© 2023 The Authors.)
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- 2023
- Full Text
- View/download PDF
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