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目的寻找与创伤性颅脑损伤（TBI）预后相关的急性期特征。方法回顾性分析354名TBI患者的人口学、急性期和慢性期特征，使用传统的基于关联分析和预测模型的策略以及一种基于特征解构的创新的研究策略，识别与预后指标-慢性期日常生活能力（ADL）受损相关的急性期特征。特征解构策略通过使用LASSO构建基于其他非ADL的慢性期指标预测ADL的模型，找到解释TBI人群ADL的关键慢性期特征维度，再分析与这些特征维度显著相关的人口学、急性期变量。结果特征解构策略将ADL在TBI人群中解构为“受伤后脑萎缩”“自知力受损程度”“四肢乏力”等慢性期特征维度，同时首次揭示了急性期特征与具体慢性期损伤特征的联系，如TBI患者昏迷时间长和GCS评分低时，慢性期“近记忆受损”的风险最大［scaled coma time OR95%CI = 94.288 （35.095， 273.231）； scaled GCS OR95%CI = 0.068 （0.030， 0.147）］；TBI患者有脑积水时，慢性期“自知力受损”和“定向力障碍”的风险最大［insight impairment OR95%CI = 6.760 （3.653，12.855）； disorientation OR95%CI = 6.538 （3.530， 12.490）］。所有策略均表明ADL受损最大的急性期风险因素为昏迷时间长、GCS评分低和有脑积水。结论本研究提出了一种新的建立TBI急性期特征和预后间关联的研究策略，识别了与预后指标ADL相关的人口学和急性期特征。

目的探讨老年人婚姻状况与轻度认知障碍（MCI）及痴呆患病率的相关性，为老年认知障碍防控提供社会学数据。方法采用整群随机抽样方法选取湖北省城乡65岁及以上老年人，在社区卫生服务中心采用面对面访谈形式完成一般情况调查和神经心理学评估，以及临床体检和实验室检查；由两名神经病学家和两名具有痴呆专业知识的神经心理学家组成诊断专家组，根据Petersen的MCI诊断标准和《中国痴呆与认知障碍诊断指南》对参与者进行MCI和痴呆诊断；采用多因素Logistic回归分析不同年龄段老年人婚姻状况与MCI及痴呆患病的相关性。结果在2018~2020年，共8 221人完成全套神经认知评估和临床体检，平均年龄71.96±5.90岁，有1 953人无配偶，占总人数的23.75%。MCI患病率为25.98%， 95%CI （24.99%，26.98%），痴呆患病率为7.24%， 95%CI （6.68%，7.80%），使用湖北省2010年人口普查数据进行年龄和性别标准化后，MCI和痴呆的患病率分别为26.28%和6.98%，无配偶者MCI及痴呆患病率［28.07%，95%CI （26.08%，30.06%）；12.45%，95%CI （10.99%，13.91%）］明显高于有配偶者［22.85%，95%CI （21.81%，23.89%）；5.62%，95%CI （5.05%，6.19%）］。多因素Logistic回归模型发现有配偶的65~69岁男性老人［P=0.028，OR=0.639，95%CI（0.429，0.952）］和80岁及以上男性老人［P=0.004，OR=0.460，95%CI（0.269，0.785）］的MCI和痴呆患病率显著低于无配偶者，然而女性老年人有无配偶与MCI和痴呆患病的关联性无差异统计性（P>0.05）。结论MCI和痴呆患病率在无配偶老年群体中增高，特别是针对65~69岁和80岁及以上的男性老人，有配偶对保护认知功能至关重要。

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Copyright of South Architecture / Nanfang Jianzhu is the property of South Architecture Editorial Office and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)

Objective To analyze the effect of down-regulation of BECN1 on the proliferation,invasion and migration of human leukemia cell line THP-1,and to explore its potential molecular mechanism. Methods The lentivirus expressing shRNA targeting at BECN1 and the negative control were constructed by RNA interference. THP-1 cells were divided into control group(control),negative control group(NC) and BECN1 interference group (BECN1-shRNA). Stable cell strains were selected by puromycin after infection by lentivirus. The down-regulation effect of BECN1 was identified by RT-qPCR and Western blot. MTT and Transwell assays were used respectively to detect the proliferation,invasion and migration of THP-1 cells. The expression of MMP 2 and MMP 9 were detected by Western blot. Results THP-1 stable cell strain expressing GFP was obtained by puromycin selection. Compared with the control and negative control group, the BECN1 mRNA and protein expression in the BECN1-shRNA group were significantly decreased (P<0.05); The proliferation,invasion and migration of cells also decreased significantly(P<0.05);The expression of MMP 2 and MMP 9 decreased (P<0.05). Conclusions Down-regulation of BECN1 may inhibit the proliferation,invasion and migration of THP-1 cells,and its molecular mechanism is related to the down-regulation of MMP 2 and MMP 9. [ABSTRACT FROM AUTHOR]

Data is a very important resource in digital economy and is also an important factor of production that stimulates China's economic development. In China, public data is the largest and most widely covered data type. Therefore, public data has enormous potential commercial and social value, and further development and utilization are urgently needed. At present, public data openness in China develops rapidly, but there are still many problems. Based on the existing literature, this paper summarizes the problems of public data opening in China into three aspects: insufficient platform coverage, poor data availability and regional differences. Based on the dialectical development perspective and the current practical situation, this paper points out that the enthusiasm of local governments plays a key role in the development of public data openness, and the lack of enthusiasm of local governments can comprehensively explain the problems of public data openness in China. Therefore, the lack of enthusiasm from local governments is the main factor hindering public data openness in China. On this basis, this paper points out that establishing a paid-use system of public data can effectively stimulate the enthusiasm of local governments, and this paper responds to the debate on establishing a paid-use system of public data. On the one hand, the paid use system of public data can bring benefits to local governments, allowing them to participate in the distribution of data source benefits, thereby enhancing their enthusiasm. By charging fee, local governments can get benefits when firms or agents use public data even when firms or agents are in other provinces. On the other hand, when local governments get benefits from public data openness, and they would promote the healthy and sustainable development of public data openness. The higher quality and more data attract more firms and agents using them, and bring more benefit to local government. However, establishing a paid use system of public data faces four controversies. Firstly, does the government have the right to charge fees? Secondly, is public data openness a public product? Thirdly, will paid-use system reduce economic efficiency? Fourthly, will paid use system lead to excessive reliance on data transfer fees by local finance? This paper responds to all controversies in the above. Finally, this paper proposes four policy recommendations based on the goal of promoting the enthusiasm of local governments and promoting the sustainable development of public data openness. These four recommendations make up a whole system which can stimulates the enthusiasm of local governments, provides macro economic tools for data market, and establishes a data trading system which is a sample for private data trading. [ABSTRACT FROM AUTHOR]

Copyright of Chinese Journal of Contemporary Pediatrics is the property of Xiangya Medical Periodical Press and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)

油橄榄具有速生、高产和果实含油率高等优点，在食品营养、医药健康和景观绿化中有着广泛的应用。为明晰我国油橄榄产业发展现状、问题和发展方向，分析了油橄榄种质资源及我国油橄榄种植与发展的现状，剖析了我国油橄榄产业面临的种质资源混杂、选育落后，品种特性认识不足，产品开发有待提高等挑战，并提出应对挑战的对策，以期为我国油橄榄产业科学发展提供参考。Olive has the advantages of rapid growth, high yield, and high oil content,and it is widely applied in food nutrition, medical health, and landscape greening. Aiming to clarify the development status, problems, and development direction of China′s olive industry, the olive germplasm resources, planting and development status of China were analyzed.The challenges faced by the olive industry in China, such as mixed germplasm resources, backward breeding and insufficient understanding of variety characteristis and the need to improve product development were analyzed, and countermeasures to deal with the challenges were put forward, in order to provide reference for the scientific development of China′s olive industry.