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1. Perpetual Observational Studies: New strategies to support efficient implementation of observational studies and randomized trials in the infectious diseases arena

Author

Hassoun-Kheir, N., van Werkhoven, C. H., Dunning, J., Jaenisch, T., van Beek, J., Bielicki, J., Butler, C., Francois, B., Harbarth, S., Padilla, A. C. Hernandez, Horby, P., Koopmans, M., Lee, J., Rodriguez-Baño, J., Tacconelli, E., Themistocleous, Y., van der Velden, A. W., Bonten, M., Goossens, H., and de Kraker, M. E. A.

Subjects
Statistics - Methodology
Abstract

The increasing threat of emerging infectious diseases and antimicrobial resistance requires more efficient, high-quality research. Perpetual Observational Studies (POS) nested within a clinical research network can improve planning, quality and efficiency of interventional and observational studies, although real-life benefits and challenges need to be assessed. Ecraid (European Clinical Research Alliance on Infectious Diseases) has initiated POS and will monitor the impact for five specific infectious syndromes., Comment: 16 pages, 2 tables

Published
2022
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3. Establishment and cryptic transmission of Zika virus in Brazil and the Americas

Author

Faria, N. R., Quick, J., Claro, I.M., Thézé, J., de Jesus, J. G., Giovanetti, M., Kraemer, M. U. G., Hill, S. C., Black, A., da Costa, A. C., Franco, L. C., Silva, S. P., Wu, C.-H., Raghwani, J., Cauchemez, S., du Plessis, L., Verotti, M. P., de Oliveira, W. K., Carmo, E. H., Coelho, G. E., Santelli, A. C. F. S., Vinhal, L. C., Henriques, C. M., Simpson, J. T., Loose, M., Andersen, K. G., Grubaugh, N. D., Somasekar, S., Chiu, C. Y., Muñoz-Medina, J. E., Gonzalez-Bonilla, C. R., Arias, C. F., Lewis-Ximenez, L. L., Baylis, S. A., Chieppe, A. O., Aguiar, S. F., Fernandes, C. A., Lemos, P. S., Nascimento, B. L. S., Monteiro, H. A. O., Siqueira, I. C., de Queiroz, M. G., de Souza, T. R., Bezerra, J. F., Lemos, M. R., Pereira, G. F., Loudal, D., Moura, L. C., Dhalia, R., França, R. F., Magalhães, T., Marques, Jr, E. T., Jaenisch, T., Wallau, G. L., de Lima, M. C., Nascimento, V., de Cerqueira, E. M., de Lima, M. M., Mascarenhas, D. L., Neto, J. P. Moura, Levin, A. S., Tozetto-Mendoza, T. R., Fonseca, S. N., Mendes-Correa, M. C., Milagres, F. P., Segurado, A., Holmes, E. C., Rambaut, A., Bedford, T., Nunes, M. R. T., Sabino, E. C., Alcantara, L. C. J., Loman, N. J., and Pybus, O. G.

Published
2017
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5. Prevalence of post-traumatic stress disorder among Palestinian children and adolescents exposed to political violence: A systematic review and meta-analysis

Author

Agbaria, N, Petzold, S, Deckert, A, Henschke, N, Veronese, G, Dambach, P, Jaenisch, T, Horstick, O, Winkler, V, Agbaria, Nisreen, Petzold, Stephanie, Deckert, Andreas, Henschke, Nicholas, Veronese, Guido, Dambach, Peter, Jaenisch, Thomas, Horstick, Olaf, Winkler, Volker, Agbaria, N, Petzold, S, Deckert, A, Henschke, N, Veronese, G, Dambach, P, Jaenisch, T, Horstick, O, Winkler, V, Agbaria, Nisreen, Petzold, Stephanie, Deckert, Andreas, Henschke, Nicholas, Veronese, Guido, Dambach, Peter, Jaenisch, Thomas, Horstick, Olaf, and Winkler, Volker

Abstract

Objective We undertook a systematic review of the literature to explore the prevalence of post-traumatic stress disorder (PTSD) in Palestinian children and adolescents exposed to political violence. This is the first systematic review and meta-analysis of the prevalence of PTSD in this population. Methods PubMed, Embase, PsycInfo, Google Scholar and Cochrane library were searched until June 2020. To estimate the prevalence of PTSD, sub-group and meta-analysis were conducted. Results The search resulted in 2786 studies, of which 28 articles representing 32 samples with a total of 15,121 participants from Gaza Strip and West Bank met either the DSM-4 or DSM-5 criteria and were included. The pooled prevalence of PTSD was 36% (95% CI 30–41%; I2 98.6%) and ranged from 6% to 70%. Sub-group analysis showed that the PTSD prevalence did not differ according to region (West Bank, Gaza Strip) and tended to decrease after including only studies using a representative sample (p<0.001), and among those with low risk of bias (p<0.001). Visual inspection of the included studies revealed significant discrepancies in study design and assessment measures. Conclusion We identified high prevalence of PTSD among Palestinian children and adolescents exposed to political violence. However, the pooled results should be interpreted with caution, due to the high heterogeneity and risk of bias in the included studies. These limitations also reflect the challenge in conceptualizing and measuring PTSD in the Palestinian context with a background of continuous and cumulative trauma. Understanding the contextual factors and developing locally adapted survey measures are of relevance to future research, public health planning, and the provision of mental healthcare in Palestine.

Published
2021

6. Severe dengue categories as research endpoints-Results from a prospective observational study in hospitalised dengue patients

Author

Rosenberger, KD, Alexander, N, Martinez, E, Lum, LCS, Dempfle, C-E, Junghanss, T, Wills, B, Jaenisch, T, and Group, DENCO Clinical Study

Subjects
Male, 0301 basic medicine, Viral Diseases, Pulmonology, Pleural effusion, RC955-962, Disease, Pathology and Laboratory Medicine, Linear Discriminant Analysis, Vascular Medicine, Dengue Fever, Dengue fever, Mathematical and Statistical Techniques, 0302 clinical medicine, Arctic medicine. Tropical medicine, Ascites, Medicine and Health Sciences, Prospective Studies, Young adult, Child, Prospective cohort study, Incidence, Incidence (epidemiology), musculoskeletal, neural, and ocular physiology, Statistics, Age Factors, Hospitals, Clinical Laboratory Sciences, 3. Good health, Hospitalization, Clinical Laboratories, Infectious Diseases, Liver, Physical Sciences, Female, Anatomy, medicine.symptom, Public aspects of medicine, RA1-1270, Research Article, Neglected Tropical Diseases, medicine.medical_specialty, Asia, Adolescent, 030231 tropical medicine, Hemorrhage, Gastroenterology and Hepatology, macromolecular substances, Research and Analysis Methods, Young Adult, 03 medical and health sciences, Signs and Symptoms, Diagnostic Medicine, Internal medicine, medicine, Humans, Severe Dengue, Statistical Methods, Inpatients, business.industry, Organ dysfunction, Public Health, Environmental and Occupational Health, Biology and Life Sciences, Tropical Diseases, medicine.disease, Pleural Effusion, Latin America, 030104 developmental biology, nervous system, business, Mathematics
Abstract

Severe dengue was perceived as one clinical disease entity until the WHO 2009 classification stratified it into severe vascular leakage, severe bleeding, and severe organ dysfunction. The objectives of this study were to investigate the potential use of severe dengue categories as endpoints for intervention research. 271 patients with severe dengue among 1734 confirmed dengue patients were followed prospectively in this hospital-based observational study in Latin America and Asia. We compared the distribution of severe dengue categories according to gender and age (below/above 15y), and determined the relative frequency and the overlap of severe dengue categories in the same patients. In a next step, we extended the analysis to candidate moderate severity categories, based on recently suggested definitions which were adapted for our purposes. Severe vascular leakage occurred in 244 (90%), severe bleeding in 39 (14%), and severe organ dysfunction in 28 (10%) of 271 severe dengue patients. A higher frequency of severe leakage was seen in children or adolescents (, Author summary Severe dengue (DHF/DSS) was perceived as one clinical disease entity until the WHO 2009 classification defined three categories: severe vascular leakage, severe bleeding, and severe organ dysfunction. Here we provide new insight about the discriminatory power and the overlap or co-occurrence of the severe dengue categories. We also respond to the need to validate standard clinical endpoints for severe dengue in well-characterized data sets. In addition, we respond to the need for moderate disease endpoints, which are recorded more frequently than the severe ones. Severe vascular leakage alone constitutes the largest group among the severe dengue categories and may be useful as endpoint for intervention or pathophysiology research. Other severe dengue categories as for example severe bleeding can also sometimes occur alone–however, this might be associated with the presence of comorbidities or individual predisposition and should be studied in more detail. Moderate disease endpoints were suggested and explored here, but need to be further investigated.

Published
2020

8. GloPID-R report on chikungunya, o'nyong-nyong and Mayaro virus, part 5: Entomological aspects

Author

Pezzi, L., Diallo, M., Rosa-Freitas, M. G., Vega-Rua, A., Ng, L. F. P., Boyer, S., Drexler, J. F., Vasilakis, N., Lourenco-de-Oliveira, R., Weaver, S. C., Kohl, A., de Lamballerie, X., Failloux, A-B, Brasil, P., Busch, M., Diamond, M. S., Drebot, M. A., Gallian, P., Jaenisch, T., LaBeaud, A. D., Lecui, M., Neyts, J., Reusken, C. B., Ribeiro, G. S., Rios, M., Rodriguez-Morales, A. J., Sall, A., Simmons, G., Simon, F., Siqueira, A. M., Pezzi, L., Diallo, M., Rosa-Freitas, M. G., Vega-Rua, A., Ng, L. F. P., Boyer, S., Drexler, J. F., Vasilakis, N., Lourenco-de-Oliveira, R., Weaver, S. C., Kohl, A., de Lamballerie, X., Failloux, A-B, Brasil, P., Busch, M., Diamond, M. S., Drebot, M. A., Gallian, P., Jaenisch, T., LaBeaud, A. D., Lecui, M., Neyts, J., Reusken, C. B., Ribeiro, G. S., Rios, M., Rodriguez-Morales, A. J., Sall, A., Simmons, G., Simon, F., and Siqueira, A. M.

Abstract

The GloPID-R (Global Research Collaboration for Infectious Disease Preparedness) chikungunya (CHIKV), o'nyong-nyong (ONNV) and Mayaro virus (MAYV) Working Group has been established to investigate natural history, epidemiology and clinical aspects of infection by these viruses. Here, we present a report dedicated to entomological aspects of CHIKV, ONNV and MAYV. Recent global expansion of chikungunya virus has been possible because CHIKV established a transmission cycle in urban settings using anthropophilic vectors such as Aedes albopictus and Aedes aegypti. MAYV and ONNV have a more limited geographic distribution, being confined to Africa (ONNV) and central-southern America (MAYV). ONNV is probably maintained through an enzootic cycle that has not been characterized yet, with Anopheles species as main vectors and humans as amplification hosts during epidemics. MAYV is transmitted by Haemagogus species in an enzootic cycle using non-human primates as the main amplification and maintenance hosts, and humans becoming sporadically infected when venturing in or nearby forest habitats. Here, we focused on the transmission cycle and natural vectors that sustain circulation of these viruses in their respective locations. The knowledge of the natural ecology of transmission and the capacity of different vectors to transmit these viruses is crucial to understand CHIKV emergence, and to assess the risk that MAYV and ONNV will expand on wide scale using anthropophilic mosquito species not normally considered primary vectors. Finally, the experts identified knowledge gaps and provided adapted recommendations, in order to address future entomological investigations in the right direction.

Published
2020

9. Zika virus infection in pregnancy: a protocol for the joint analysis of the prospective cohort studies of the ZIKAlliance, ZikaPLAN and ZIKAction consortia

Author

Ades, A.E. (Anthony), Brickley, E.B. (Elizabeth B.), Alexander, N. (Neal), Brown, D. (David), Jaenisch, T. (Thomas), Miranda-Filho, D.B. (Demócrito de Barros), Pohl, M. (Moritz), Rosenberger, K.D. (Kerstin D.), Soriano-Arandes, A. (Antoni), Thorne, C. (Claire), Ximenes, R.A.A. (Ricardo Arraes de Alencar), de Araújo, T.V.B. (Thalia Velho Barreto), Avelino-Silva, V.I. (Vivian I.), Bethencourt Castillo, S.E. (Sarah Esperanza), Borja Aburto, V.H. (Victor Hugo), Brasil, P. (Patrícia), Christie, C.D.C. (Celia D C), de Souza, W.V. (Wayner Vieira), Gotuzzo H, J.E. (Jose Eduardo), Hoen, B. (Bruno), Koopmans D.V.M., M.P.G. (Marion), Martelli, C.M.T. (Celina Maria Turchi), Martins Teixeira, M. (Mauro), Marques, E.T.A. (Ernesto T A), Miranda, M.C. (Maria Consuelo), Montarroyos, U.R. (Ulisses Ramos), Moreira, M.E. (Maria Elisabeth), Morris, J.G. (J Glenn), Rockx, B. (Barry), Saba Villarroel, P.M. (Paola Mariela), Soria Segarra, C. (Carmen), Tami, A. (Adriana), Turchi, M.D. (Marília Dalva), Giaquinto, C. (Carlo), de Lamballerie, X. (Xavier), Wilder-Smith, A. (Annelies), Ades, A.E. (Anthony), Brickley, E.B. (Elizabeth B.), Alexander, N. (Neal), Brown, D. (David), Jaenisch, T. (Thomas), Miranda-Filho, D.B. (Demócrito de Barros), Pohl, M. (Moritz), Rosenberger, K.D. (Kerstin D.), Soriano-Arandes, A. (Antoni), Thorne, C. (Claire), Ximenes, R.A.A. (Ricardo Arraes de Alencar), de Araújo, T.V.B. (Thalia Velho Barreto), Avelino-Silva, V.I. (Vivian I.), Bethencourt Castillo, S.E. (Sarah Esperanza), Borja Aburto, V.H. (Victor Hugo), Brasil, P. (Patrícia), Christie, C.D.C. (Celia D C), de Souza, W.V. (Wayner Vieira), Gotuzzo H, J.E. (Jose Eduardo), Hoen, B. (Bruno), Koopmans D.V.M., M.P.G. (Marion), Martelli, C.M.T. (Celina Maria Turchi), Martins Teixeira, M. (Mauro), Marques, E.T.A. (Ernesto T A), Miranda, M.C. (Maria Consuelo), Montarroyos, U.R. (Ulisses Ramos), Moreira, M.E. (Maria Elisabeth), Morris, J.G. (J Glenn), Rockx, B. (Barry), Saba Villarroel, P.M. (Paola Mariela), Soria Segarra, C. (Carmen), Tami, A. (Adriana), Turchi, M.D. (Marília Dalva), Giaquinto, C. (Carlo), de Lamballerie, X. (Xavier), and Wilder-Smith, A. (Annelies)

Abstract

INTRODUCTION: Zika virus (ZIKV) infection in pregnancy has been associated with microcephaly and severe neurological damage to the fetus. Our aim is to document the risks of adverse pregnancy and birth outcomes and the prevalence of laboratory markers of congenital infection in deliveries to women experiencing ZIKV infection during pregnancy, using data from European Commission-funded prospective cohort studies in 20 centres in 11 countries across Latin America and the Caribbean. METHODS AND ANALYSIS: We will carry out a centre-by-centre analysis of the risks of adverse pregnancy and birth outcomes, comparing women with confirmed and suspected ZIKV infection in pregnancy to those with no evidence of infection in pregnancy. We will document the proportion of deliveries in which laboratory markers of congenital infection were present. Finally, we will investigate the associations of trimester of maternal infection in pregnancy, presence or absence of maternal symptoms of acute ZIKV infection and previous flavivirus infections with adverse outcomes and with markers of congenital infection. Centre-specific estimates will be pooled using a two-stage approach. ETHICS AND DISSEMINATION: Ethical approval was obtained at each centre. Findings will be presented at international conferences and published in peer-reviewed open access journals and discussed with local public health officials and representatives of the national Ministries of Health, Pan American Health Organization and WHO involved with ZIKV prevention and control activities.

Published
2020
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10. GloPID-R report on chikungunya, o'nyong-nyong and Mayaro virus, part 5: Entomological aspects

Author

Pezzi, L. (L.), Diallo, M. (M.), Rosa-Freitas, M.G. (M. G.), Vega-Rua, A. (A.), Ng, L.F.P. (L. F.P.), Boyer, S. (S.), Drexler, J.-F. (Jan-Felix), Vasilakis, N. (Nikos), Lourenco-de-Oliveira, R. (R.), Weaver, S.C. (S. C.), Kohl, A. (A.), de Lamballerie, X. (X.), Failloux, A.-B. (A. B.), Brasil, P. (P.), Busch, M. (M.), Diamond, M.S. (M. S.), Drebot, M.A. (M. A.), Gallian, P. (P.), Jaenisch, T. (T.), LaBeaud, A.D. (A. D.), Lecuit, M. (M.), Neyts, J. (J.), Reusken, C.B.E.M. (Chantal), Ribeiro, G.S. (G. S.), Rios, M. (M.), Rodriguez-Morales, A.J. (A. J.), Sall, A. (A.), Simmons, G. (G.), Simon, F. (F.), Siqueira, A.M. (A. M.), Pezzi, L. (L.), Diallo, M. (M.), Rosa-Freitas, M.G. (M. G.), Vega-Rua, A. (A.), Ng, L.F.P. (L. F.P.), Boyer, S. (S.), Drexler, J.-F. (Jan-Felix), Vasilakis, N. (Nikos), Lourenco-de-Oliveira, R. (R.), Weaver, S.C. (S. C.), Kohl, A. (A.), de Lamballerie, X. (X.), Failloux, A.-B. (A. B.), Brasil, P. (P.), Busch, M. (M.), Diamond, M.S. (M. S.), Drebot, M.A. (M. A.), Gallian, P. (P.), Jaenisch, T. (T.), LaBeaud, A.D. (A. D.), Lecuit, M. (M.), Neyts, J. (J.), Reusken, C.B.E.M. (Chantal), Ribeiro, G.S. (G. S.), Rios, M. (M.), Rodriguez-Morales, A.J. (A. J.), Sall, A. (A.), Simmons, G. (G.), Simon, F. (F.), and Siqueira, A.M. (A. M.)

Abstract

The GloPID-R (Global Research Collaboration for Infectious Disease Preparedness) chikungunya (CHIKV), o'nyong-nyong (ONNV) and Mayaro virus (MAYV) Working Group has been established to investigate natural history, epidemiology and clinical aspects of infection by these viruses. Here, we present a report dedicated to entomological aspects of CHIKV, ONNV and MAYV. Recent global expansion of chikungunya virus has been possible because CHIKV established a transmission cycle in urban settings using anthropophilic vectors such as Aedes albopictus and Aedes aegypti. MAYV and ONNV have a more limited geographic distribution, being confined to Africa (ONNV) and central-southern America (MAYV). ONNV is probably maintained through an enzootic cycle that has not been characterized yet, with Anopheles species as main vectors and humans as amplification hosts during epidemics. MAYV is transmitted by Haemagogus species in an enzootic cycle using non-human primates as the main amplification and maintenance hosts, and humans becoming sporadically infected when venturing

Published
2020
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11. GloPID-R report on chikungunya, o'nyong-nyong and Mayaro virus, part 5: Entomological aspects

Author

Pezzi, L, Diallo, M, Rosa-Freitas, MG, Vega-Rua, A, Ng, LFP, Boyer, S, Drexler, JF, Vasilakis, N, Lourenco-De-Oliveira, R, Weaver, SC, Kohl, A, de Lamballerie, X, Failloux, AB, Brasil, P, Busch, M, Diamond, MS, Drebot, MA, Gallian, P, Jaenisch, T, LaBeaud, AD, Lecuit, M, Neyts, J, Reusken, Chantal, Ribeiro, GS, del Rios, M, Rodriguez-Morales, AJ, Sall, A, Simmons, G, Simon, F, Siqueira, AM, Pezzi, L, Diallo, M, Rosa-Freitas, MG, Vega-Rua, A, Ng, LFP, Boyer, S, Drexler, JF, Vasilakis, N, Lourenco-De-Oliveira, R, Weaver, SC, Kohl, A, de Lamballerie, X, Failloux, AB, Brasil, P, Busch, M, Diamond, MS, Drebot, MA, Gallian, P, Jaenisch, T, LaBeaud, AD, Lecuit, M, Neyts, J, Reusken, Chantal, Ribeiro, GS, del Rios, M, Rodriguez-Morales, AJ, Sall, A, Simmons, G, Simon, F, and Siqueira, AM

Published
2020

14. GloPID-R report on chikungunya, o'nyong-nyong and Mayaro virus, part 5: Entomological aspects

Author

Pezzi, L., primary, Diallo, M., additional, Rosa-Freitas, M.G., additional, Vega-Rua, A., additional, Ng, L.F.P., additional, Boyer, S., additional, Drexler, J.F., additional, Vasilakis, N., additional, Lourenco-de-Oliveira, R., additional, Weaver, S.C., additional, Kohl, A., additional, de Lamballerie, X., additional, Failloux, A.-B., additional, Brasil, P., additional, Busch, M., additional, Diamond, M.S., additional, Drebot, M.A., additional, Gallian, P., additional, Jaenisch, T., additional, LaBeaud, A.D., additional, Lecuit, M., additional, Neyts, J., additional, Reusken, C.B., additional, Ribeiro, G.S., additional, Rios, M., additional, Rodriguez-Morales, A.J., additional, Sall, A., additional, Simmons, G., additional, Simon, F., additional, and Siqueira, A.M., additional

Published
2020
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15. GloPID-R report on chikungunya, o'nyong-nyong and Mayaro virus, part 2: Epidemiological distribution of o'nyong-nyong virus

Author

Pezzi, L., primary, LaBeaud, A.D., additional, Reusken, C.B., additional, Drexler, J.F., additional, Vasilakis, N., additional, Diallo, M., additional, Simon, F., additional, Jaenisch, T., additional, Gallian, P., additional, Sall, A., additional, Failloux, A.B., additional, Weaver, S.C., additional, de Lamballerie, X., additional, Boyer, S., additional, Brasil, P., additional, Busch, M., additional, Diamond, M.S., additional, Drebot, M.A., additional, Kohl, A., additional, Lecuit, M., additional, Lourenço-de-Oliveira, R., additional, Neyts, J., additional, Lfp, Ng, additional, Ribeiro, G.S., additional, Rios, M., additional, Rodriguez-Morales, A.J., additional, Rosa-Freitas, M.G., additional, Simmons, G., additional, Siqueira, A.M., additional, and Vega Rua, A., additional

Published
2019
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16. Estudio de seroprevalencia de infección por Virus Zika en Chincha, Ica, Peru

Author

Cachay, Rodrigo, Schwalb, Alvaro, Acevedo-Rodríguez, Juan Gonzalo, Merino, Xiomara, Talledo, Michael, Guerra, Humberto, Gotuzzo, Eduardo, and Jaenisch, T.

Subjects
Virus Zika, seroprevalencia, infección
Abstract

Introducción: La provincia de Chincha reportó 4,317 casos de infección por virus Zika (ZIKV) durante el 2017. Debido a que 62% de casos de Zika son asintomáticos es importante estimar el estado de seroprevalencia en la población ya que existen estudios que sugieren protección inmunológica a infecciones futuras. El objetivo del estudio fue estimar la seroprevalencia de ZIKV y sus factores asociados en dos distritos de Chincha. Metodología: Estudio transversal realizado entre marzo y mayo del 2019 en los distritos de Chincha Baja (CB) y Pueblo Nuevo (PN); este último fue el distrito con más casos reportados de Zika en el brote del 2017. La población fueron participantes de ambos sexos, entre 20 a 40 años, residentes de sus distritos mínimo 1 año sin viajes mayores a 1 mes durante dicho periodo. Se registraron variables demográficas, antecedentes, y factores de riesgo para infección por arbovirus y se analizaron las muestras para IgG anti-ZIKV. Resultados: Se enrolaron 400 participantes, siendo 78.8% del sexo femenino. Se encontró una prevalencia de 10.3% para IgG-anti ZIKV entre ambos distritos, siendo 17.6% y 3% en PN y CB, respectivamente. Los residentes de PN tienen 5.83 veces la prevalencia de IgG anti-ZIKV positivo en comparación a la población de CB (IC95% 2.51 - 13.56, p < 0.001). Ingresos mensuales menores al sueldo mínimo (RP: 2.76; IC95% 1.34 - 5.71), antecedente personal y familiar de fiebre y rash (RP:5.49, IC95% 3.16 - 9.55; RP:2.56, IC95% 1.41 - 4.67, respectivamente) se asociaron a títulos de IgG positivo. Conclusiones: La prevalencia en Chincha es similar a la reportada en otro países de Latinoamérica. Se debe fomentar métodos de protección contra vectores y formular estrategias de prevención ante la posibilidad de un futuro brote en CB. 2019-09-05

Published
2019

17. GloPID-R report on chikungunya, o'nyong-nyong and Mayaro virus, part 3: Epidemiological distribution of Mayaro virus

Author

Pezzi, L., Rodriguez-Morales, A.J., Reusken, C.B., Ribeiro, G.S., Labeaud, A.D., Lourenço-De-Oliveira, R., Brasil, P., Lecuit, M., Failloux, Anna-Bella, Gallian, P., Jaenisch, T., Simon, F., Siqueira, A.M., Rosa-Freitas, M.G., Vega Rua, A., Weaver, S.C., Drexler, J.F., Vasilakis, N., de Lamballerie, Xavier, Boyer, Sébastien, Busch, M., Diallo, M., Diamond, M.S., Drebot, M.A., Kohl, A., Neyts, J., Ng, L.F.P., Rios, M., Sall, A., Simmons, G., Virology, Unité des Virus Emergents (UVE), Institut de Recherche pour le Développement (IRD)-Aix Marseille Université (AMU)-Institut National de la Santé et de la Recherche Médicale (INSERM), Laboratoire de Virologie [UNIV Corse-Inserm] (EA7310), Université Pascal Paoli (UPP)-Institut National de la Santé et de la Recherche Médicale (INSERM), Universidad Tecnológica de Pereira [Colombie] (UTP), National Institute for Public Health and the Environment [Bilthoven] (RIVM), Erasmus University Medical Center [Rotterdam] (Erasmus MC), Universidade Federal da Bahia (UFBA), Stanford School of Medicine [Stanford], Stanford Medicine, Stanford University-Stanford University, Fundação Oswaldo Cruz (FIOCRUZ), Réseau International des Instituts Pasteur (RIIP), Biologie des Infections - Biology of Infection, Institut Pasteur [Paris] (IP)-Institut National de la Santé et de la Recherche Médicale (INSERM), Université Paris Descartes - Paris 5 (UPD5), CHU Necker - Enfants Malades [AP-HP], Assistance publique - Hôpitaux de Paris (AP-HP) (AP-HP), Imagine - Institut des maladies génétiques (IHU) (Imagine - U1163), Institut National de la Santé et de la Recherche Médicale (INSERM)-Université Paris Cité (UPCité), Arbovirus et Insectes Vecteurs - Arboviruses and Insect Vectors, Institut Pasteur [Paris] (IP), Etablissement Français du Sang - Alpes-Méditerranée (EFS - Alpes-Méditerranée), Etablissement Français du Sang, Heidelberg University Hospital [Heidelberg], Hôpital d'Instruction des Armées Laveran, Service de Santé des Armées, Institut Pasteur de la Guadeloupe, The University of Texas Medical Branch (UTMB), German Center for Infection Research - partner site Hannover-Braunschweig (DZIF), Charité - UniversitätsMedizin = Charité - University Hospital [Berlin], Humboldt University Of Berlin, Berlin Institute of Health (BIH), Institut Pasteur du Cambodge, University of California [San Francisco] (UC San Francisco), University of California (UC), Institut Pasteur de Dakar, Washington University in Saint Louis (WUSTL), Public Health Agency of Canada, MRC - University of Glasgow Centre for Virus Research, Laboratory of Virology and Chemotherapy [KU Leuven], Catholic University of Leuven - Katholieke Universiteit Leuven (KU Leuven)-Rega Institute of Medical Research [Leuven, Belgium], Catholic University of Leuven - Katholieke Universiteit Leuven (KU Leuven), Agency for science, technology and research [Singapore] (A*STAR), U.S. Food and Drug Administration (FDA), Publication fees were covered by the Global Research Collaboration for Infectious Disease Preparedness (GloPID-R)., DEMESLAY GOUGAM, MARIE, Institut National de la Santé et de la Recherche Médicale (INSERM)-Université Pascal Paoli (UPP), Institut Pasteur [Paris]-Institut National de la Santé et de la Recherche Médicale (INSERM), Institut National de la Santé et de la Recherche Médicale (INSERM)-Université de Paris (UP), Institut Pasteur [Paris], Humboldt-Universität zu Berlin, University of California [San Francisco] (UCSF), University of California, and Fundação Oswaldo Cruz / Oswaldo Cruz Foundation (FIOCRUZ)

Subjects
Primates, GloPID-R chikungunya, o'nyong-nyong and Mayaro virus Working Group, 030231 tropical medicine, Alphavirus, Genome, Viral, Mosquito Vectors, Disease Outbreaks, 03 medical and health sciences, 0302 clinical medicine, Seroepidemiologic Studies, Virology, Zoonoses, Animals, Humans, O'nyong-nyong Virus, Serologic Tests, 030212 general & internal medicine, Pathology, Molecular, ComputingMilieux_MISCELLANEOUS, Phylogeny, Disease Reservoirs, Pharmacology, [SDV.MP.VIR] Life Sciences [q-bio]/Microbiology and Parasitology/Virology, Alphavirus Infections, 3. Good health, Caribbean Region, [SDV.MP.VIR]Life Sciences [q-bio]/Microbiology and Parasitology/Virology, Chikungunya Fever, Americas, Chikungunya virus
Abstract

ispartof: ANTIVIRAL RESEARCH vol:172 ispartof: location:Netherlands status: published

Published
2019

18. Study protocol for the multicentre cohorts of Zika virus infection in pregnant women, infants, and acute clinical cases in Latin America and the Caribbean: The ZIKAlliance consortium

Author

Avelino-Silva, V.I. (Vivian I.), Mayaud, P. (Philippe), Tami, A. (Adriana), Miranda, M.C. (Maria C.), Rosenberger, K.D. (Kerstin D.), Alexander, N. (Neal), Nacul, L. (Luis), Segurado, A. (Aluisio), Pohl, M. (Moritz), Bethencourt, S. (Sarah), Villar, L.A. (Luis A.), Viana, I.F.T. (Isabelle F. T.), Rabello, R. (Renata), Soria, C. (Carmen), Salgado, S.P. (Silvia P.), Gotuzzo, E. (Eduardo), Guzmán, M.G. (María G.), Martínez, P.A. (Pedro A.), López-Gatell, H. (Hugo), Hegewisch-Taylor, J. (Jennifer), Borja-Aburto, V.H. (Victor H.), Gonzalez, C. (Cesar), Netto, E.M. (Eduardo M.), Saba Villarroel, P.M. (Paola M.), Hoen, B. (Bruno), Brasil, P. (Patrícia), Marques, E.T.A. (Ernesto T. A.), Rockx, B. (Barry), Koopmans, M. (Marion), de Lamballerie, X. (Xavier), Jaenisch, T. (Thomas), Morales, I. (Ivonne), Tobian, F. (Frank), Uhlmann, L. (Lorenz), Schretzmann, J. (Julius), Leege, A. (Annika), Lins, R.D. (Roberto D.), De Filippis, A.M.B. (Ana Maria Bispo), Duarte, A.C.M. (Ana Claudia Machado), De Melo Espíndola, O. (Otavio), Bonaldo, M. (Myrna), Damasceno, L. (Luana), Avelino-Silva, V. (Vivian), Sabino, E. (Ester), Mendes-Correa, M.C. (Maria Cassia), Netto, E.M. (Eduardo Martins), Falcon, C. (Cristel), Rodríguez, E. (Egri), Matos, V. (Victmar), Tinedo, M.J. (Maria José), La Rosa, Y. (Yenifer), Murillo, M. (Marianela), Villar, L.A. (Luis Angel), Miranda, M.C. (Maria Consuelo), Lozano, A. (Anyela), Herrera, V.M. (Victor Mauricio), Gomez, A. (Adriana), Gelvez, R.M. (Rosa Margarita), Ortiz, R. (Ricardo), Dimitrakis, L. (Lady), Salgado, S.P. (Silvia Paola), Arrata, M.R. (Mary Regato), Allison, H.G. (Humberto Guerra), Talledo, M. (Michael), Villarroel, P.M.S. (Paola Mariela Saba), Torres, E.M. (Eric Martínez), Martínez Rodríguez, P.A. (Pedro A.), Vera, M.A. (Mayling Alvarez), Santana, B.G. (Belkis Galindo), Reyes, A. (Alicia), Álvarez, S.S. (Silvia Serrano), Dorticós, D.F. (Diana Ferriol), Alpuche-Aranda, C. (Celia), González-Diaz, E. (Esteban), Pavía-Ruz, N. (Norma), Borja-Aburto, V.H. (Victor Hugo), Grajales, C. (Concepción), Rojas, T. (Teresita), Arriaga, L. (Lumumba), Vallejos, A. (Alfonso), Tynevez, D. (Dominique), De Lamballerie, X. (Xavier), Thirion, L. (Laurence), Drexler, J.-F. (Jan-Felix), Gorp, E.C.M. (Eric) van, Koopmans D.V.M., M.P.G. (Marion), Avelino-Silva, V.I. (Vivian I.), Mayaud, P. (Philippe), Tami, A. (Adriana), Miranda, M.C. (Maria C.), Rosenberger, K.D. (Kerstin D.), Alexander, N. (Neal), Nacul, L. (Luis), Segurado, A. (Aluisio), Pohl, M. (Moritz), Bethencourt, S. (Sarah), Villar, L.A. (Luis A.), Viana, I.F.T. (Isabelle F. T.), Rabello, R. (Renata), Soria, C. (Carmen), Salgado, S.P. (Silvia P.), Gotuzzo, E. (Eduardo), Guzmán, M.G. (María G.), Martínez, P.A. (Pedro A.), López-Gatell, H. (Hugo), Hegewisch-Taylor, J. (Jennifer), Borja-Aburto, V.H. (Victor H.), Gonzalez, C. (Cesar), Netto, E.M. (Eduardo M.), Saba Villarroel, P.M. (Paola M.), Hoen, B. (Bruno), Brasil, P. (Patrícia), Marques, E.T.A. (Ernesto T. A.), Rockx, B. (Barry), Koopmans, M. (Marion), de Lamballerie, X. (Xavier), Jaenisch, T. (Thomas), Morales, I. (Ivonne), Tobian, F. (Frank), Uhlmann, L. (Lorenz), Schretzmann, J. (Julius), Leege, A. (Annika), Lins, R.D. (Roberto D.), De Filippis, A.M.B. (Ana Maria Bispo), Duarte, A.C.M. (Ana Claudia Machado), De Melo Espíndola, O. (Otavio), Bonaldo, M. (Myrna), Damasceno, L. (Luana), Avelino-Silva, V. (Vivian), Sabino, E. (Ester), Mendes-Correa, M.C. (Maria Cassia), Netto, E.M. (Eduardo Martins), Falcon, C. (Cristel), Rodríguez, E. (Egri), Matos, V. (Victmar), Tinedo, M.J. (Maria José), La Rosa, Y. (Yenifer), Murillo, M. (Marianela), Villar, L.A. (Luis Angel), Miranda, M.C. (Maria Consuelo), Lozano, A. (Anyela), Herrera, V.M. (Victor Mauricio), Gomez, A. (Adriana), Gelvez, R.M. (Rosa Margarita), Ortiz, R. (Ricardo), Dimitrakis, L. (Lady), Salgado, S.P. (Silvia Paola), Arrata, M.R. (Mary Regato), Allison, H.G. (Humberto Guerra), Talledo, M. (Michael), Villarroel, P.M.S. (Paola Mariela Saba), Torres, E.M. (Eric Martínez), Martínez Rodríguez, P.A. (Pedro A.), Vera, M.A. (Mayling Alvarez), Santana, B.G. (Belkis Galindo), Reyes, A. (Alicia), Álvarez, S.S. (Silvia Serrano), Dorticós, D.F. (Diana Ferriol), Alpuche-Aranda, C. (Celia), González-Diaz, E. (Esteban), Pavía-Ruz, N. (Norma), Borja-Aburto, V.H. (Victor Hugo), Grajales, C. (Concepción), Rojas, T. (Teresita), Arriaga, L. (Lumumba), Vallejos, A. (Alfonso), Tynevez, D. (Dominique), De Lamballerie, X. (Xavier), Thirion, L. (Laurence), Drexler, J.-F. (Jan-Felix), Gorp, E.C.M. (Eric) van, and Koopmans D.V.M., M.P.G. (Marion)

Abstract

Background: The European Commission (EC) Horizon 2020 (H2020)-funded ZIKAlliance Consortium designed a multicentre study including pregnant women (PW), children (CH) and natural history (NH) cohorts. Clinical sites were selected over a wide geographic range within Latin America and the Caribbean, taking into account the dynamic course of the ZIKV epidemic. Methods: Recruitment to the PW cohort will take place in antenatal care clinics. PW will be enrolled regardless of symptoms and followed over the course of pregnancy, approximately every 4 weeks. PW will be revisited at delivery (or after miscarriage/abortion) to assess birth outcomes, including microcephaly and other congenital abnormalities according to the evolving definition of congenital Zika syndrome (CZS). After birth, children will be followed for 2 years in the CH cohort. Follow-up visits are scheduled at ages 1-3, 4-6, 12, and 24 months to assess neurocognitive and developmental milestones. In addition, a NH cohort for the characterization of symptomatic rash/fever illness was designed, including follow-up to capture persisting health problems. Blood, urine, and other biological materials will be collected, and tested for ZIKV and other relevant arboviral diseases (dengue, chikungunya, yellow fever) using RT-PCR or serological methods. A virtual, decentralized biobank will be created. Reciprocal clinical monitoring has been established between partner sites. Substudies of ZIKV seroprevalence, transmission

Published
2019
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19. GloPID-R report on chikungunya, o'nyong-nyong and Mayaro virus, part 3: Epidemiological distribution of Mayaro virus

Author

Pezzi, L. (L.), Rodriguez-Morales, A.J. (A. J.), Reusken, C.B.E.M. (Chantal), Ribeiro, G.S. (G. S.), LaBeaud, A.D. (A. D.), Lourenço-de-Oliveira, R. (R.), Brasil, P. (P.), Lecuit, M. (M.), Failloux, A.B. (A. B.), Gallian, P. (P.), Jaenisch, T. (T.), Simon, F. (F.), Siqueira, A.M. (A. M.), Rosa-Freitas, M.G. (M. G.), Vega Rua, A. (A.), Weaver, S.C. (S. C.), Drexler, J.-F. (Jan-Felix), Vasilakis, N. (Nikos), de Lamballerie X, (), Boyer, S. (S.), Busch, M. (M.), Diallo, M. (M.), Diamond, M.S. (M. S.), Drebot, M.A. (M. A.), Kohl, A. (A.), Neyts, J. (J.), Ng, L.F.P. (L. F.P.), Rios, M. (M.), Sall, A. (A.), Simmons, G. (G.), Pezzi, L. (L.), Rodriguez-Morales, A.J. (A. J.), Reusken, C.B.E.M. (Chantal), Ribeiro, G.S. (G. S.), LaBeaud, A.D. (A. D.), Lourenço-de-Oliveira, R. (R.), Brasil, P. (P.), Lecuit, M. (M.), Failloux, A.B. (A. B.), Gallian, P. (P.), Jaenisch, T. (T.), Simon, F. (F.), Siqueira, A.M. (A. M.), Rosa-Freitas, M.G. (M. G.), Vega Rua, A. (A.), Weaver, S.C. (S. C.), Drexler, J.-F. (Jan-Felix), Vasilakis, N. (Nikos), de Lamballerie X, (), Boyer, S. (S.), Busch, M. (M.), Diallo, M. (M.), Diamond, M.S. (M. S.), Drebot, M.A. (M. A.), Kohl, A. (A.), Neyts, J. (J.), Ng, L.F.P. (L. F.P.), Rios, M. (M.), Sall, A. (A.), and Simmons, G. (G.)

Published
2019
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20. GloPID-R report on chikungunya, o'nyong-nyong and Mayaro virus, part 2: Epidemiological distribution of o'nyong-nyong virus

Author

Pezzi, L. (L.), LaBeaud, A.D. (A. D.), Reusken, C.B.E.M. (Chantal), Drexler, J.-F. (Jan-Felix), Vasilakis, N. (Nikos), Diallo, M. (M.), Simon, F. (F.), Jaenisch, T. (T.), Gallian, P. (P.), Sall, A. (A.), Failloux, A.B. (A. B.), Weaver, S.C. (S. C.), de Lamballerie, X. (Xavier), Boyer, S. (S.), Brasil, P. (P.), Busch, M. (M.), Diamond, M.S. (M. S.), Drebot, M.A. (M. A.), Kohl, A. (A.), Lecuit, M. (M.), Lourenço-de-Oliveira, R. (R.), Neyts, J. (J.), Lfp, N. (Ng), Ribeiro, G.S. (G. S.), Rios, M. (M.), Rodriguez-Morales, A.J. (A. J.), Rosa-Freitas, M.G. (M. G.), Simmons, G. (G.), Siqueira, A.M. (A. M.), Vega Rua, A. (A.), Pezzi, L. (L.), LaBeaud, A.D. (A. D.), Reusken, C.B.E.M. (Chantal), Drexler, J.-F. (Jan-Felix), Vasilakis, N. (Nikos), Diallo, M. (M.), Simon, F. (F.), Jaenisch, T. (T.), Gallian, P. (P.), Sall, A. (A.), Failloux, A.B. (A. B.), Weaver, S.C. (S. C.), de Lamballerie, X. (Xavier), Boyer, S. (S.), Brasil, P. (P.), Busch, M. (M.), Diamond, M.S. (M. S.), Drebot, M.A. (M. A.), Kohl, A. (A.), Lecuit, M. (M.), Lourenço-de-Oliveira, R. (R.), Neyts, J. (J.), Lfp, N. (Ng), Ribeiro, G.S. (G. S.), Rios, M. (M.), Rodriguez-Morales, A.J. (A. J.), Rosa-Freitas, M.G. (M. G.), Simmons, G. (G.), Siqueira, A.M. (A. M.), and Vega Rua, A. (A.)

Abstract

The GloPID-R (Global Research Collaboration for Infectious Disease Preparedness) chikungunya (CHIKV), o'nyong-nyong (ONNV) and Mayaro virus (MAYV) Working Group has been established to identify gaps of knowledge about the natural history, epidemiology and medical management of infection by these viruses, and to provide adapted recommendations for future investigations. Here, we present a report dedicated to ONNV epidemiological distribution. Two large-scale ONNV outbreaks have been identified in Africa in the last 60 years, interspersed with sporadic serosurveys and case reports of returning travelers. The assessment of the real scale of ONNV circulation in Africa remains a difficult task and surveillance studies are necessary to fill this gap. The identification of ONNV etiology is made complicated by the absence of multiplex tools in co-circulatio

Published
2019
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21. Understanding the relation between Zika virus infection during pregnancy and adverse fetal, infant and child outcomes: A protocol for a systematic review and individual participant data meta-analysis of longitudinal studies of pregnant women and their infants and children

Author

Wilder-Smith, A. (Annelies), Wei, Y. (Yinghui), Araújo, T.V.B.D. (Thalia Velho Barreto De), Vankerkhove, M. (Maria), Turchi Martelli, C.M. (Celina Maria), Turchi, M.D. (Marília Dalva), Teixeira, M. (Mauro), Tami, A. (Adriana), Souza, J. (João), Sousa, P. (Patricia), Soriano-Arandes, A. (Antoni), Soria-Segarra, C. (Carmen), Sanchez Clemente, N. (Nuria), Rosenberger, K.D. (Kerstin Daniela), Reveiz, L. (Ludovic), Prata-Barbosa, A. (Arnaldo), Pomar, L. (Léo), Pelá Rosado, L.E. (Luiza Emylce), Perez, F. (Freddy), Passos, S.D. (Saulo D.), Nogueira, M. (Mauricio), Noel, T.P. (Trevor P.), Moura Da Silva, A. (Antônio), Moreira, M.E. (Maria Elisabeth), Morales, I. (Ivonne), Miranda Montoya, M.C. (Maria Consuelo), Miranda-Filho, D.D.B. (Demócrito De Barros), Maxwell, L. (Lauren), Macpherson, C.N.L. (Calum N. L.), Low, N. (Nicola), Lan, Z. (Zhiyi), Labeaud, A.D. (Angelle Desiree), Koopmans D.V.M., M.P.G. (Marion), Kim, C. (Caron), João, E. (Esaú), Jaenisch, T. (Thomas), Hofer, C.B. (Cristina Barroso), Gustafson, P. (Paul), Gérardin, P. (Patrick), Ganz, J.S. (Jucelia S.), Dias, A.C.F. (Ana Carolina Fialho), Elias, V. (Vanessa), Duarte, G. (Geraldo), Debray, T.P. (Thomas P.A.), Cafferata, M.L. (María Luisa), Buekens, P. (Pierre), Broutet, N. (Nathalie), Brickley, E.B. (Elizabeth B.), Brasil, P. (Patrícia), Brant, F. (Fátima), Bethencourt, S. (Sarah), Benedetti, A. (Andrea), Avelino-Silva, V.L. (Vivian Lida), Ximenes, R.A.D.A. (Ricardo Arraes De Alencar), Alves Da Cunha, A. (Antonio), Alger, J. (Jackeline), Wilder-Smith, A. (Annelies), Wei, Y. (Yinghui), Araújo, T.V.B.D. (Thalia Velho Barreto De), Vankerkhove, M. (Maria), Turchi Martelli, C.M. (Celina Maria), Turchi, M.D. (Marília Dalva), Teixeira, M. (Mauro), Tami, A. (Adriana), Souza, J. (João), Sousa, P. (Patricia), Soriano-Arandes, A. (Antoni), Soria-Segarra, C. (Carmen), Sanchez Clemente, N. (Nuria), Rosenberger, K.D. (Kerstin Daniela), Reveiz, L. (Ludovic), Prata-Barbosa, A. (Arnaldo), Pomar, L. (Léo), Pelá Rosado, L.E. (Luiza Emylce), Perez, F. (Freddy), Passos, S.D. (Saulo D.), Nogueira, M. (Mauricio), Noel, T.P. (Trevor P.), Moura Da Silva, A. (Antônio), Moreira, M.E. (Maria Elisabeth), Morales, I. (Ivonne), Miranda Montoya, M.C. (Maria Consuelo), Miranda-Filho, D.D.B. (Demócrito De Barros), Maxwell, L. (Lauren), Macpherson, C.N.L. (Calum N. L.), Low, N. (Nicola), Lan, Z. (Zhiyi), Labeaud, A.D. (Angelle Desiree), Koopmans D.V.M., M.P.G. (Marion), Kim, C. (Caron), João, E. (Esaú), Jaenisch, T. (Thomas), Hofer, C.B. (Cristina Barroso), Gustafson, P. (Paul), Gérardin, P. (Patrick), Ganz, J.S. (Jucelia S.), Dias, A.C.F. (Ana Carolina Fialho), Elias, V. (Vanessa), Duarte, G. (Geraldo), Debray, T.P. (Thomas P.A.), Cafferata, M.L. (María Luisa), Buekens, P. (Pierre), Broutet, N. (Nathalie), Brickley, E.B. (Elizabeth B.), Brasil, P. (Patrícia), Brant, F. (Fátima), Bethencourt, S. (Sarah), Benedetti, A. (Andrea), Avelino-Silva, V.L. (Vivian Lida), Ximenes, R.A.D.A. (Ricardo Arraes De Alencar), Alves Da Cunha, A. (Antonio), and Alger, J. (Jackeline)

Abstract

Introduction Zika virus (ZIKV) infection during pregnancy is a known cause of microcephaly and other congenital and developmental anomalies. In the absence of a ZIKV vaccine or prophylactics, principal investigators (PIs) and international leaders in ZIKV research have formed the ZIKV Individual Participant Data (IPD) Consortium to identify, collect and synthesise IPD from longitudinal studies of pregnant women that measure ZIKV infection during pregnancy and fetal, infant or child outcomes. Methods and analysis We will identify eligible studies through the ZIKV IPD Consortium membership and a systematic review and invite study PIs to participate in the IPD meta-analysis (IPD-MA). We will use the combined dataset to estimate the relative and absolute risk of congenital Zika syndrome (CZS), including microcephaly and late symptomatic congenital infections; identify and explore sources of heterogeneity in those estimates and develop and validate a risk prediction model to identify the pregnancies at the highest risk of CZS or adverse developmental outcomes. The variable accuracy of diagnostic assays and differences in exposure and outcome definitions means that included studies will have a higher level of systematic variability, a component of measurement error, than an IPD-MA of studies of an established pathogen. We will use expert testimony, existing internal and external diagnostic accuracy validation studies and laboratory external quality assessments to inform the distribution of measurement error in our models. We will apply both Bayesian and frequentist methods to directly account for these and other sources of uncertainty. Ethics and dissemination The IPD-MA was deemed exempt from ethical review. We will convene a group of patient advocates to evaluate the ethical implications and utility of the risk stratification tool. Findings from these analyses will be shared via national and international conferences and through publication in open access, peer-reviewed

Published
2019
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22. GloPID-R report on Chikungunya, O'nyong-nyong and Mayaro virus, part I: Biological diagnostics

Author

Pezzi, L., Reusken, C.B.E.M. (Chantal), Weaver, S.C., Drexler, JF, Busch, M., LaBeaud, A.D., Diamond, M.S., Vasilakis, N, Drebot, M.A., Siqueira, A.M., Ribeiro, G.S., Kohl, A., Lecuit, M., Ng, L.F.P., Gallian, P., de Lamballerie, X, Boyer, S. (Scott), Brasil, P., Diallo, M., Failloux, A.B., Jaenisch, T., Lourenco-De-Oliveira, R., Neyts, J., del Rios, M., Rodriguez-Morales, A.J., Rosa-Freitas, M.G., Sall, A., Simmons, G., Simon, F., Rua, A.V., Glo, P.I.D.R.C.O.n.-n., Pezzi, L., Reusken, C.B.E.M. (Chantal), Weaver, S.C., Drexler, JF, Busch, M., LaBeaud, A.D., Diamond, M.S., Vasilakis, N, Drebot, M.A., Siqueira, A.M., Ribeiro, G.S., Kohl, A., Lecuit, M., Ng, L.F.P., Gallian, P., de Lamballerie, X, Boyer, S. (Scott), Brasil, P., Diallo, M., Failloux, A.B., Jaenisch, T., Lourenco-De-Oliveira, R., Neyts, J., del Rios, M., Rodriguez-Morales, A.J., Rosa-Freitas, M.G., Sall, A., Simmons, G., Simon, F., Rua, A.V., and Glo, P.I.D.R.C.O.n.-n.

Abstract

The GloPID-R (Global Research Collaboration for Infectious Disease Preparedness) Chikungunya (CHIKV), O'nyong-nyong (ONNV) and Mayaro virus (MAYV) Working Group is investigating

Published
2019
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23. The current and future global distribution and population at risk of dengue

Author

Messina, JP, Brady, OJ, Golding, N, Kraemer, MUG, Wint, GRW, Ray, SE, Pigott, DM, Shearer, FM, Johnson, K, Earl, L, Marczak, LB, Shirude, S, Weaver, ND, Gilbert, M, Velayudhan, R, Jones, P, Jaenisch, T, Scott, TW, Reiner, RC, Hay, S, Messina, JP, Brady, OJ, Golding, N, Kraemer, MUG, Wint, GRW, Ray, SE, Pigott, DM, Shearer, FM, Johnson, K, Earl, L, Marczak, LB, Shirude, S, Weaver, ND, Gilbert, M, Velayudhan, R, Jones, P, Jaenisch, T, Scott, TW, Reiner, RC, and Hay, S

Abstract

Dengue is a mosquito-borne viral infection that has spread throughout the tropical world over the past 60 years and now affects over half the world's population. The geographical range of dengue is expected to further expand due to ongoing global phenomena including climate change and urbanization. We applied statistical mapping techniques to the most extensive database of case locations to date to predict global environmental suitability for the virus as of 2015. We then made use of climate, population and socioeconomic projections for the years 2020, 2050 and 2080 to project future changes in virus suitability and human population at risk. This study is the first to consider the spread of Aedes mosquito vectors to project dengue suitability. Our projections provide a key missing piece of evidence for the changing global threat of vector-borne disease and will help decision-makers worldwide to better prepare for and respond to future changes in dengue risk.

Published
2019

24. GloPID-R report on chikungunya, o'nyong-nyong and Mayaro virus, part 3: Epidemiological distribution of Mayaro virus

Author

Pezzi, L, Rodriguez-Morales, AJ, Reusken, Chantal, Ribeiro, GS, LaBeaud, AD, Lourenco-De-Oliveira, R, Brasil, P, Lecuit, M, Failloux, AB, Gallian, P, Jaenisch, T, Simon, F, Siqueira, AM, Rosa-Freitas, MG, Rua, AV, Weaver, SC, Drexler, JF, Vasilakis, N, de Lamballerie, X, Boyer, S, Busch, M, Diallo, M, Diamond, MS, Drebot, MA, Kohl, A, Neyts, J, Ng, LFP, del Rios, M, Sall, A, Simmons, G, Pezzi, L, Rodriguez-Morales, AJ, Reusken, Chantal, Ribeiro, GS, LaBeaud, AD, Lourenco-De-Oliveira, R, Brasil, P, Lecuit, M, Failloux, AB, Gallian, P, Jaenisch, T, Simon, F, Siqueira, AM, Rosa-Freitas, MG, Rua, AV, Weaver, SC, Drexler, JF, Vasilakis, N, de Lamballerie, X, Boyer, S, Busch, M, Diallo, M, Diamond, MS, Drebot, MA, Kohl, A, Neyts, J, Ng, LFP, del Rios, M, Sall, A, and Simmons, G

Published
2019

25. GloPID-R report on chikungunya, o'nyong-nyong and Mayaro virus, part 2: Epidemiological distribution of o'nyong-nyong virus

Author

Pezzi, L, LaBeaud, AD, Reusken, Chantal, Drexler, JF, Vasilakis, N, Diallo, M, Simon, F, Jaenisch, T, Gallian, P, Sall, A, Failloux, AB, Weaver, SC, de Lamballerie, X, Boyer, S, Brasil, P, Busch, M, Diamond, MS, Drebot, MA, Kohl, A, Lecuit, M, Lourenco-De-Oliveira, R, Neyts, J, Lfp, N, Ribeiro, GS, del Rios, M, Rodriguez-Morales, AJ, Rosa-Freitas, MG, Simmons, G, Siqueira, AM, Rua, AV, Pezzi, L, LaBeaud, AD, Reusken, Chantal, Drexler, JF, Vasilakis, N, Diallo, M, Simon, F, Jaenisch, T, Gallian, P, Sall, A, Failloux, AB, Weaver, SC, de Lamballerie, X, Boyer, S, Brasil, P, Busch, M, Diamond, MS, Drebot, MA, Kohl, A, Lecuit, M, Lourenco-De-Oliveira, R, Neyts, J, Lfp, N, Ribeiro, GS, del Rios, M, Rodriguez-Morales, AJ, Rosa-Freitas, MG, Simmons, G, Siqueira, AM, and Rua, AV

Published
2019

26. GloPID-R report on Chikungunya, O'nyong-nyong and Mayaro virus, part I: Biological diagnostics

Author

Pezzi, L, Reusken, Chantal, Weaver, SC, Drexler, JF, Busch, M, LaBeaud, AD, Diamond, MS, Vasilakis, N, Drebot, MA, Siqueira, AM, Ribeiro, GS, Kohl, A, Lecuit, M, Ng, LFP, Gallian, P, de Lamballerie, X, Boyer, S, Brasil, P, Diallo, M, Failloux, AB, Jaenisch, T, Lourenco-De-Oliveira, R, Neyts, J, del Rios, M, Rodriguez-Morales, AJ, Rosa-Freitas, MG, Sall, A, Simmons, G, Simon, F, Rua, AV, Glo, PIDRCOn-n, Pezzi, L, Reusken, Chantal, Weaver, SC, Drexler, JF, Busch, M, LaBeaud, AD, Diamond, MS, Vasilakis, N, Drebot, MA, Siqueira, AM, Ribeiro, GS, Kohl, A, Lecuit, M, Ng, LFP, Gallian, P, de Lamballerie, X, Boyer, S, Brasil, P, Diallo, M, Failloux, AB, Jaenisch, T, Lourenco-De-Oliveira, R, Neyts, J, del Rios, M, Rodriguez-Morales, AJ, Rosa-Freitas, MG, Sall, A, Simmons, G, Simon, F, Rua, AV, and Glo, PIDRCOn-n

Published
2019

27. GloPID-R report on Chikungunya, O'nyong-nyong and Mayaro virus, part I: Biological diagnostics

Author

Pezzi, L., primary, Reusken, C.B., additional, Weaver, S.C., additional, Drexler, J.F., additional, Busch, M., additional, LaBeaud, A.D., additional, Diamond, M.S., additional, Vasilakis, N., additional, Drebot, M.A., additional, Siqueira, A.M., additional, Ribeiro, G.S., additional, Kohl, A., additional, Lecuit, M., additional, Ng, L.F.P., additional, Gallian, P., additional, de Lamballerie, X., additional, Boyer, S., additional, Brasil, P., additional, Diallo, M., additional, Failloux, A.B., additional, Jaenisch, T., additional, Lourenço-de-Oliveira, R., additional, Neyts, J., additional, Rios, M., additional, Rodriguez-Morales, A.J., additional, Rosa-Freitas, M.G., additional, Sall, A., additional, Simmons, G., additional, Simon, F., additional, and Vega Rua, A., additional

Published
2019
Full Text
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28. Global, regional, and national under-5 mortality, adult mortality, age-specific mortality, and life expectancy, 1970-2016: A systematic analysis for the Global Burden of Disease Study 2016.

Author

Shetty B.P., Tekle D.Y., Temam Shifa G., Temsah M.-H., Terkawi A.S., Tesema C.L., Tesssema B., Theis A., Thomas N., Thompson A.H., Thomson A.J., Tiruye T.Y., Tobe-Gai R., Tonelli M., Topor-Madry R., Topouzis F., Tortajada M., Tran B.X., Truelsen T., Trujillo U., Tsilimparis N., Tuem K.B., Tuzcu E.M., Tyrovolas S., Ukwaja K.N., Undurraga E.A., Uthman O.A., Uzochukwu B.S.C., Van Boven J.F.M., Varakin Y.Y., Varughese S., Vasankari T., Vasconcelos A.M.N., Venketasubramanian N., Vidavalur R., Violante F.S., Vishnu A., Vladimirov S.K., Vlassov V.V., Vollset S.E., Vos T., Waid J.L., Wakayo T., Wang Y.-P., Weichenthal S., Weiderpass E., Weintraub R.G., Werdecker A., Wesana J., Wijeratne T., Wilkinson J.D., Wiysonge C.S., Woldeyes B.G., Wolfe C.D.A., Workicho A., Workie S.B., Xavier D., Xu G., Yaghoubi M., Yakob B., Yalew A.Z., Yan L.L., Yano Y., Yaseri M., Ye P., Yimam H.H., Yip P., Yirsaw B.D., Yonemoto N., Yoon S.-J., Yotebieng M., Younis M.Z., Zaidi Z., El Sayed Zaki M., Zeeb H., Zenebe Z.M., Zerfu T.A., Zhang A.L., Zhang X., Zodpey S., Zuhlke L.J., Lopez A.D., Murray C.J.L., De Courten B., Singh A., Thrift A.G., Wang H., Abajobir A.A., Abate K.H., Abbafati C., Abbas K.M., Abd-Allah F., Abera S.F., Abraha H.N., Abu-Raddad L.J., Abu-Rmeileh N.M.E., Adedeji I.A., Adedoyin R.A., Adetifa I.M.O., Adetokunboh O., Afshin A., Aggarwal R., Agrawal A., Agrawal S., Ahmad Kiadaliri A., Ahmed M.B., Aichour A.N., Aichour I., Aichour M.T.E., Aiyar S., Akanda A.S., Akinyemiju T.F., Akseer N., Al-Eyadhy A., Al Lami F.H., Alabed S., Alahdab F., Al-Aly Z., Alam K., Alam N., Alasfoor D., Aldridge R.W., Alene K.A., Alhabib S., Ali R., Alizadeh-Navaei R., Aljunid S.M., Alkaabi J.M., Alkerwi A., Alla F., Allam S.D., Allebeck P., Al-Raddadi R., Alsharif U., Altirkawi K.A., Martin E.A., Alvis-Guzman N., Amare A.T., Ameh E.A., Amini E., Ammar W., Amoako Y.A., Anber N., Andrei C.L., Androudi S., Ansari H., Ansha M.G., Antonio C.A.T., Anwari P., Arnlov J., Arora M., Artaman A., Aryal K.K., Asayesh H., Asgedom S.W., Asghar R.J., Assadi R., Atey T.M., Atre S.R., Avila-Burgos L., Avokpaho E.F.G.A., Awasthi A., Ayala Quintanilla B.P., Babalola T.K., Bacha U., Badawi A., Balakrishnan K., Balalla S., Barac A., Barber R.M., Barboza M.A., Barker-Collo S.L., Barnighausen T., Barquera S., Barregard L., Barrero L.H., Baune B.T., Bazargan-Hejazi S., Bedi N., Beghi E., Bejot Y., Bekele B.B., Bell M.L., Bello A.K., Bennett D.A., Bennett J.R., Bensenor I.M., Benson J., Berhane A., Berhe D.F., Bernabe E., Beuran M., Beyene A.S., Bhala N., Bhansali A., Bhaumik S., Bhutta Z.A., Bikbov B., Birungi C., Biryukov S., Bisanzio D., Bizuayehu H.M., Bjerregaard P., Blosser C.D., Boneya D.J., Boufous S., Bourne R.R.A., Brazinova A., Breitborde N.J.K., Brenner H., Brugha T.S., Bukhman G., Bulto L.N.B., Bumgarner B.R., Burch M., Butt Z.A., Cahill L.E., Cahuana-Hurtado L., Campos-Nonato I.R., Car J., Car M., Cardenas R., Carpenter D.O., Carrero J.J., Carter A., Castaneda-Orjuela C.A., Castillo Rivas J., Castro F.F., Castro R.E., Catala-Lopez F., Chen H., Chiang P.P.-C., Chibalabala M., Chisumpa V.H., Chitheer A.A., Choi J.-Y.J., Christensen H., Christopher D.J., Ciobanu L.G., Cirillo M., Cohen A.J., Colquhoun S.M., Coresh J., Criqui M.H., Cromwell E.A., Crump J.A., Dandona L., Dandona R., Dargan P.I., Das Neves J., Davey G., Davitoiu D.V., Davletov K., De Leo D., Degenhardt L., Deiparine S., Dellavalle R.P., Deribe K., Deribew A., Des Jarlais D.C., Dey S., Dharmaratne S.D., Dherani M.K., Diaz-Torne C., Ding E.L., Dixit P., Djalalinia S., Do H.P., Doku D.T., Donnelly C.A., Dos Santos K.P.B., Douwes-Schultz D., Driscoll T.R., Duan L., Dubey M., Duncan B.B., Dwivedi L.K., Ebrahimi H., El Bcheraoui C., Ellingsen C.L., Enayati A., Endries A.Y., Ermakov S.P., Eshetie S., Eshrati B., Eskandarieh S., Esteghamati A., Estep K., Fanuel F.B.B., Faro A., Farvid M.S., Farzadfar F., Feigin V.L., Fereshtehnejad S.-M., Fernandes J.G., Fernandes J.C., Feyissa T.R., Filip I., Fischer F., Foigt N., Foreman K.J., Frank T., Franklin R.C., Fraser M., Friedman J., Frostad J.J., Fullman N., Furst T., Furtado J.M., Futran N.D., Gakidou E., Gambashidze K., Gamkrelidze A., Gankpe F.G., Garcia-Basteiro A.L., Gebregergs G.B., Gebrehiwot T.T., Gebrekidan K.G., Gebremichael M.W., Gelaye A.A., Geleijnse J.M., Gemechu B.L., Gemechu K.S., Genova-Maleras R., Gesesew H.A., Gething P.W., Gibney K.B., Gill P.S., Gillum R.F., Giref A.Z., Girma B.W., Giussani G., Goenka S., Gomez B., Gona P.N., Gopalani S.V., Goulart A.C., Graetz N., Gugnani H.C., Gupta P.C., Gupta R., Gupta T., Gupta V., Haagsma J.A., Hafezi-Nejad N., Haghparast Bidgoli H., Hakuzimana A., Halasa Y.A., Hamadeh R.R., Hambisa M.T., Hamidi S., Hammami M., Hancock J., Handal A.J., Hankey G.J., Hao Y., Harb H.L., Hareri H.A., Harikrishnan S., Haro J.M., Hassanvand M.S., Havmoeller R., Hay R.J., Hay S.I., He F., Heredia-Pi I.B., Herteliu C., Hilawe E.H., Hoek H.W., Horita N., Hosgood H.D., Hostiuc S., Hotez P.J., Hoy D.G., Hsairi M., Htet A.S., Hu G., Huang H., Huang J.J., Iburg K.M., Igumbor E.U., Ileanu B.V., Inoue M., Irenso A.A., Irvine C.M.S., Islam N., Jacobsen K.H., Jaenisch T., Jahanmehr N., Jakovljevic M.B., Javanbakht M., Jayatilleke A.U., Jeemon P., Jensen P.N., Jha V., Jin Y., John D., John O., Johnson S.C., Jonas J.B., Jurisson M., Kabir Z., Kadel R., Kahsay A., Kalkonde Y., Kamal R., Kan H., Karch A., Karema C.K., Karimi S.M., Karthikeyan G., Kasaeian A., Kassaw N.A., Kassebaum N.J., Kastor A., Katikireddi S.V., Kaul A., Kawakami N., Kazanjan K., Keiyoro P.N., Kelbore S.G., Kemp A.H., Kengne A.P., Keren A., Kereselidze M., Kesavachandran C.N., Ketema E.B., Khader Y.S., Khalil I.A., Khan E.A., Khan G., Khang Y.-H., Khera S., Khoja A.T.A., Khosravi M.H., Kibret G.D., Kieling C., Kim C.-I., Kim D., Kim P., Kim S., Kim Y.J., Kimokoti R.W., Kinfu Y., Kishawi S., Kissimova-Skarbek K.A., Kissoon N., Kivimaki M., Knudsen A.K., Kokubo Y., Kopec J.A., Kosen S., Koul P.A., Koyanagi A., Kravchenko M., Krohn K.J., Kuate Defo B., Kucuk Bicer B., Kuipers E.J., Kulikoff X.R., Kulkarni V.S., Kumar G.A., Kumar P., Kumsa F.A., Kutz M., Lachat C., Lagat A.K., Lager A.C.J., Lal D.K., Lalloo R., Lambert N., Lan Q., Lansingh V.C., Larson H.J., Larsson A., Laryea D.O., Lavados P.M., Laxmaiah A., Lee P.H., Leigh J., Leung J., Leung R., Levi M., Li Y., Liao Y., Liben M.L., Lim S.S., Linn S., Lipshultz S.E., Liu S., Lodha R., Logroscino G., Lorch S.A., Lorkowski S., Lotufo P.A., Lozano R., Lunevicius R., Lyons R.A., Ma S., Macarayan E.R.K., Machado I.E., Mackay M.T., Magdy Abd El Razek M., Magis-Rodriguez C., Mahdavi M., Majdan M., Majdzadeh R., Majeed A., Malekzadeh R., Malhotra R., Malta D.C., Mantovani L.G., Manyazewal T., Mapoma C.C., Marczak L.B., Marks G.B., Martinez-Raga J., Martins-Melo F.R., Massano J., Maulik P.K., Mayosi B.M., Mazidi M., McAlinden C., McGarvey S.T., McGrath J.J., McKee M., Mehata S., Mehndiratta M.M., Mehta K.M., Meier T., Mekonnen T.C., Meles K.G., Memiah P., Memish Z.A., Mendoza W., Mengesha M.M., Mengistie M.A., Mengistu D.T., Menon G.R., Menota B.G., Mensah G.A., Meretoja A., Meretoja T.J., Mezgebe H.B., Micha R., Mikesell J., Miller T.R., Mills E.J., Minnig S., Mirarefin M., Mirrakhimov E.M., Misganaw A., Mishra S.R., Mohammad K.A., Mohammadi A., Mohammed K.E., Mohammed S., Mohan M.B.V., Mohanty S.K., Mokdad A.H., Molla Assaye A., Mollenkopf S.K., Molokhia M., Monasta L., Montanez Hernandez J.C., Montico M., Mooney M.D., Moore A.R., Moradi-Lakeh M., Moraga P., Morawska L., Moreno Velasquez I., Mori R., Morrison S.D., Mruts K.B., Mueller U.O., Mullany E., Muller K., Murthy G.V.S., Murthy S., Musa K.I., Nachega J.B., Nagata C., Nagel G., Naghavi M., Naidoo K.S., Nanda L., Nangia V., Nascimento B.R., Natarajan G., Negoi I., Nguyen C.T., Nguyen G., Nguyen Q.L., Nguyen T.H., Ningrum D.N.A., Nisar M.I., Nomura M., Nong V.M., Norheim O.F., Norrving B., Noubiap J.J.N., Nyakarahuka L., Obermeyer C.M., O'Donnell M.J., Ogbo F.A., Oh I.-H., Okoro A., Oladimeji O., Olagunju A.T., Olusanya B.O., Olusanya J.O., Oren E., Ortiz A., Osgood-Zimmerman A., Ota E., Owolabi M.O., Oyekale A.S., Mahesh P.A., Pacella R.E., Pakhale S., Pana A., Panda B.K., Panda-Jonas S., Park E.-K., Parsaeian M., Patel T., Patten S.B., Patton G.C., Paudel D., Pereira D.M., Perez-Padilla R., Perez-Ruiz F., Perico N., Pervaiz A., Pesudovs K., Peterson C.B., Petri W.A., Petzold M., Phillips M.R., Piel F.B., Pigott D.M., Pishgar F., Plass D., Polinder S., Popova S., Postma M.J., Poulton R.G., Pourmalek F., Prasad N., Purwar M., Qorbani M., Rabiee R.H.S., Radfar A., Rafay A., Rahimi-Movaghar A., Rahimi-Movaghar V., Rahman M., Rahman M.H.U., Rahman S.U., Rai R.K., Rajsic S., Ram U., Rana S.M., Ranabhat C.L., Rao P.V., Rawaf S., Ray S.E., Rego M.A.S., Rehm J., Reiner R.C., Remuzzi G., Renzaho A.M.N.N., Resnikoff S., Rezaei S., Rezai M.S., Ribeiro A.L., Rokni M.B., Ronfani L., Roshandel G., Roth G.A., Rothenbacher D., Roy A., Rubagotti E., Ruhago G.M., Saadat S., Sabde Y.D., Sachdev P.S., Sadat N., Safdarian M., Safi S., Safiri S., Sagar R., Sahathevan R., Sahebkar A., Sahraian M.A., Salama J., Salamati P., Salomon J.A., Salvi S.S., Samy A.M., Sanabria J.R., Sanchez-Nino M.D., Santos I.S., Santric Milicevic M.M., Sarmiento-Suarez R., Sartorius B., Satpathy M., Sawhney M., Saxena S., Saylan M.I., Schmidt M.I., Schneider I.J.C., Schutte A.E., Schwebel D.C., Schwendicke F., Seedat S., Seid A.M., Sepanlou S.G., Servan-Mori E.E., Shackelford K.A., Shaheen A., Shahraz S., Shaikh M.A., Shamsipour M., Shamsizadeh M., Islam S.M.S., Sharma J., Sharma R., She J., Shen J., Shi P., Shibuya K., Shigematsu M., Shiri R., Shiue I., Shrime M.G., Sigfusdottir I.D., Silberberg D.H., Silpakit N., Silva D.A.S., Silva J.P., Silveira D.G.A., Sindi S., Singh J.A., Singh P.K., Singh V., Sinha D.N., Skiadaresi E., Sligar A., Smith D.L., Sobaih B.H.A., Sobngwi E., Soneji S., Soriano J.B., Sreeramareddy C.T., Srinivasan V., Stathopoulou V., Steel N., Stein D.J., Steiner C., Stockl H., Stokes M.A., Strong M., Sufiyan M.B., Suliankatchi R.A., Sunguya B.F., Sur P.J., Swaminathan S., Sykes B.L., Szoeke C.E.I., Tabares-Seisdedos R., Tadakamadla S.K., Tadese F., Tandon N., Tanne D., Tarajia M., Tavakkoli M., Taveira N., Tehrani-Banihashemi A., Tekelab T., Shetty B.P., Tekle D.Y., Temam Shifa G., Temsah M.-H., Terkawi A.S., Tesema C.L., Tesssema B., Theis A., Thomas N., Thompson A.H., Thomson A.J., Tiruye T.Y., Tobe-Gai R., Tonelli M., Topor-Madry R., Topouzis F., Tortajada M., Tran B.X., Truelsen T., Trujillo U., Tsilimparis N., Tuem K.B., Tuzcu E.M., Tyrovolas S., Ukwaja K.N., Undurraga E.A., Uthman O.A., Uzochukwu B.S.C., Van Boven J.F.M., Varakin Y.Y., Varughese S., Vasankari T., Vasconcelos A.M.N., Venketasubramanian N., Vidavalur R., Violante F.S., Vishnu A., Vladimirov S.K., Vlassov V.V., Vollset S.E., Vos T., Waid J.L., Wakayo T., Wang Y.-P., Weichenthal S., Weiderpass E., Weintraub R.G., Werdecker A., Wesana J., Wijeratne T., Wilkinson J.D., Wiysonge C.S., Woldeyes B.G., Wolfe C.D.A., Workicho A., Workie S.B., Xavier D., Xu G., Yaghoubi M., Yakob B., Yalew A.Z., Yan L.L., Yano Y., Yaseri M., Ye P., Yimam H.H., Yip P., Yirsaw B.D., Yonemoto N., Yoon S.-J., Yotebieng M., Younis M.Z., Zaidi Z., El Sayed Zaki M., Zeeb H., Zenebe Z.M., Zerfu T.A., Zhang A.L., Zhang X., Zodpey S., Zuhlke L.J., Lopez A.D., Murray C.J.L., De Courten B., Singh A., Thrift A.G., Wang H., Abajobir A.A., Abate K.H., Abbafati C., Abbas K.M., Abd-Allah F., Abera S.F., Abraha H.N., Abu-Raddad L.J., Abu-Rmeileh N.M.E., Adedeji I.A., Adedoyin R.A., Adetifa I.M.O., Adetokunboh O., Afshin A., Aggarwal R., Agrawal A., Agrawal S., Ahmad Kiadaliri A., Ahmed M.B., Aichour A.N., Aichour I., Aichour M.T.E., Aiyar S., Akanda A.S., Akinyemiju T.F., Akseer N., Al-Eyadhy A., Al Lami F.H., Alabed S., Alahdab F., Al-Aly Z., Alam K., Alam N., Alasfoor D., Aldridge R.W., Alene K.A., Alhabib S., Ali R., Alizadeh-Navaei R., Aljunid S.M., Alkaabi J.M., Alkerwi A., Alla F., Allam S.D., Allebeck P., Al-Raddadi R., Alsharif U., Altirkawi K.A., Martin E.A., Alvis-Guzman N., Amare A.T., Ameh E.A., Amini E., Ammar W., Amoako Y.A., Anber N., Andrei C.L., Androudi S., Ansari H., Ansha M.G., Antonio C.A.T., Anwari P., Arnlov J., Arora M., Artaman A., Aryal K.K., Asayesh H., Asgedom S.W., Asghar R.J., Assadi R., Atey T.M., Atre S.R., Avila-Burgos L., Avokpaho E.F.G.A., Awasthi A., Ayala Quintanilla B.P., Babalola T.K., Bacha U., Badawi A., Balakrishnan K., Balalla S., Barac A., Barber R.M., Barboza M.A., Barker-Collo S.L., Barnighausen T., Barquera S., Barregard L., Barrero L.H., Baune B.T., Bazargan-Hejazi S., Bedi N., Beghi E., Bejot Y., Bekele B.B., Bell M.L., Bello A.K., Bennett D.A., Bennett J.R., Bensenor I.M., Benson J., Berhane A., Berhe D.F., Bernabe E., Beuran M., Beyene A.S., Bhala N., Bhansali A., Bhaumik S., Bhutta Z.A., Bikbov B., Birungi C., Biryukov S., Bisanzio D., Bizuayehu H.M., Bjerregaard P., Blosser C.D., Boneya D.J., Boufous S., Bourne R.R.A., Brazinova A., 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Enayati A., Endries A.Y., Ermakov S.P., Eshetie S., Eshrati B., Eskandarieh S., Esteghamati A., Estep K., Fanuel F.B.B., Faro A., Farvid M.S., Farzadfar F., Feigin V.L., Fereshtehnejad S.-M., Fernandes J.G., Fernandes J.C., Feyissa T.R., Filip I., Fischer F., Foigt N., Foreman K.J., Frank T., Franklin R.C., Fraser M., Friedman J., Frostad J.J., Fullman N., Furst T., Furtado J.M., Futran N.D., Gakidou E., Gambashidze K., Gamkrelidze A., Gankpe F.G., Garcia-Basteiro A.L., Gebregergs G.B., Gebrehiwot T.T., Gebrekidan K.G., Gebremichael M.W., Gelaye A.A., Geleijnse J.M., Gemechu B.L., Gemechu K.S., Genova-Maleras R., Gesesew H.A., Gething P.W., Gibney K.B., Gill P.S., Gillum R.F., Giref A.Z., Girma B.W., Giussani G., Goenka S., Gomez B., Gona P.N., Gopalani S.V., Goulart A.C., Graetz N., Gugnani H.C., Gupta P.C., Gupta R., Gupta T., Gupta V., Haagsma J.A., Hafezi-Nejad N., Haghparast Bidgoli H., Hakuzimana A., Halasa Y.A., Hamadeh R.R., Hambisa M.T., Hamidi S., Hammami M., Hancock J., Handal A.J., Hankey G.J., Hao Y., Harb H.L., Hareri H.A., Harikrishnan S., Haro J.M., Hassanvand M.S., Havmoeller R., Hay R.J., Hay S.I., He F., Heredia-Pi I.B., Herteliu C., Hilawe E.H., Hoek H.W., Horita N., Hosgood H.D., Hostiuc S., Hotez P.J., Hoy D.G., Hsairi M., Htet A.S., Hu G., Huang H., Huang J.J., Iburg K.M., Igumbor E.U., Ileanu B.V., Inoue M., Irenso A.A., Irvine C.M.S., Islam N., Jacobsen K.H., Jaenisch T., Jahanmehr N., Jakovljevic M.B., Javanbakht M., Jayatilleke A.U., Jeemon P., Jensen P.N., Jha V., Jin Y., John D., John O., Johnson S.C., Jonas J.B., Jurisson M., Kabir Z., Kadel R., Kahsay A., Kalkonde Y., Kamal R., Kan H., Karch A., Karema C.K., Karimi S.M., Karthikeyan G., Kasaeian A., Kassaw N.A., Kassebaum N.J., Kastor A., Katikireddi S.V., Kaul A., Kawakami N., Kazanjan K., Keiyoro P.N., Kelbore S.G., Kemp A.H., Kengne A.P., Keren A., Kereselidze M., Kesavachandran C.N., Ketema E.B., Khader Y.S., Khalil I.A., Khan E.A., Khan G., Khang Y.-H., Khera S., Khoja A.T.A., 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Abstract

Background: Detailed assessments of mortality patterns, particularly age-specific mortality, represent a crucial input that enables health systems to target interventions to specific populations. Understanding how all-cause mortality has changed with respect to development status can identify exemplars for best practice. To accomplish this, the Global Burden of Diseases, Injuries, and Risk Factors Study 2016 (GBD 2016) estimated age-specific and sex-specific all-cause mortality between 1970 and 2016 for 195 countries and territories and at the subnational level for the five countries with a population greater than 200 million in 2016. Method(s): We have evaluated how well civil registration systems captured deaths using a set of demographic methods called death distribution methods for adults and from consideration of survey and census data for children younger than 5 years. We generated an overall assessment of completeness of registration of deaths by dividing registered deaths in each location-year by our estimate of all-age deaths generated from our overall estimation process. For 163 locations, including subnational units in countries with a population greater than 200 million with complete vital registration (VR) systems, our estimates were largely driven by the observed data, with corrections for small fluctuations in numbers and estimation for recent years where there were lags in data reporting (lags were variable by location, generally between 1 year and 6 years). For other locations, we took advantage of different data sources available to measure under-5 mortality rates (U5MR) using complete birth histories, summary birth histories, and incomplete VR with adjustments; we measured adult mortality rate (the probability of death in individuals aged 15-60 years) using adjusted incomplete VR, sibling histories, and household death recall. We used the U5MR and adult mortality rate, together with crude death rate due to HIV in the GBD model life table system, t

Published
2017

29. Global, regional, and national under-5 mortality, adult mortality, age-specific mortality, and life expectancy, 1970-2016: a systematic analysis for the Global Burden of Disease Study 2016

Author

Wang, H, Abajobir, AA, Abate, KH, Abbafati, C, Abbas, KM, Abd-Allah, F, Abera, SF, Abraha, HN, Abu-Raddad, LJ, Abu-Rmeileh, NME, Adedeji, IA, Adedoyin, RA, Adetifa, IMO, Adetokunboh, O, Afshin, A, Aggarwal, R, Agrawal, A, Agrawal, S, Kiadaliri, AA, Ahmed, MB, Aichour, AN, Aichour, I, Aichour, MTE, Aiyar, S, Akanda, S, Akinyemiju, TF, Akseer, N, Al-Eyadhy, A, Al Lami, FH, Alabed, S, Alahdab, F, Al-Aly, Z, Alam, K, Alam, N, Alasfoor, D, Aldridge, RW, Alene, KA, Alhabib, S, Ali, R, Alizadeh-Navaei, R, Aljunid, SM, Alkaabi, JM, Alkerwi, A, Alla, F, Allam, SD, Allebeck, P, Al-Raddadi, R, Alsharif, U, Altirkawi, KA, Martin, EA, Alvis-Guzman, N, Amare, AT, Ameh, EA, Amini, E, Ammar, W, Amoako, YA, Anber, N, Andrei, CL, Androudi, S, Ansari, H, Ansha, MG, Antonio, CAT, Anwari, P, Arnlov, J, Arora, M, Al, A, Aryal, KK, Asayesh, H, Asgedom, SW, Asghar, RJ, Assadi, R, Atey, TM, Atre, SR, Avila-Burgos, L, Avokpaho, EFGA, Awasthi, A, Quintanilla, BPA, Babalola, TK, Bacha, U, Badawi, A, Balakrishnan, K, Balalla, S, Barac, A, Barber, RM, Barboza, MA, Barker-Collo, SL, Barnighausen, T, Barquera, S, Barregard, L, Barrero, LH, Baune, BT, Bazargan-Hejazi, S, Bedi, N, Beghi, E, Bejot, Y, Bekele, BB, Bell, ML, Bello, AK, Bennett, DA, Bennett, JR, Bensenor, IM, Benson, J, Berhane, A, Berhe, DF, Bernabe, E, Beuran, M, Beyene, AS, Bhala, N, Bhansali, A, Bhaumik, S, Bhutta, ZA, Bikbov, B, Birungi, C, Biryukov, S, Bisanzio, D, Bizuayehu, HM, Bjerregaard, P, Blosser, CD, Boneya, DJ, Boufous, S, Bourne, RRA, Brazinova, A, Breitborde, NJK, Brenner, H, Brugha, TS, Bukhman, G, Negesa, L, Bulto, B, Bumgarner, BR, Burch, M, Butt, ZA, Cahill, LE, Cahuana-Hurtado, L, Campos-Nonato, IR, Car, J, Car, M, Crdenas, R, Carpenter, DO, Carrero, JJ, Carter, A, Castaneda-Orjuela, CA, Rivas, JC, Castro, FF, Castro, RE, Catala-Lopez, F, Chen, H, Chiang, PP-C, Chibalabala, M, Chisumpa, VH, Chitheer, AA, Choi, J-YJ, Christensen, H, Christopher, DJ, Ciobanu, LG, Cirillo, M, Cohen, AJ, Colquhoun, SM, Coresh, J, 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Lim, SS, Linn, S, Lipshultz, SE, Liu, S, Lodha, R, Logroscino, G, Lorch, SA, Lorkowski, S, Lotufo, PA, Lozano, R, Lunevicius, R, Lyons, RA, Ma, S, Macarayan, ERK, Machado, IE, Mackay, MT, Abd el Razek, MM, Magis-Rodriguez, C, Mahdavi, M, Majdan, M, Majdzadeh, R, Majeed, A, Malekzadeh, R, Malhotra, R, Malta, DC, Mantovani, LG, Manyazewal, T, Mapoma, CC, Marczak, LB, Marks, GB, Martinez-Raga, J, Martins-Melo, FR, Massano, J, Maulik, PK, Mayosi, BM, Mazidi, M, McAlinden, C, McGarvey, ST, McGrath, JJ, Mckee, M, Mehata, S, Mehndiratta, MM, Mehta, KM, Meier, T, Mekonnen, TC, Meles, KG, Memiah, P, Memish, ZA, Mendoza, W, Mengesha, MM, Mengistie, MA, Tadese, D, Menon, MGR, Menota, BG, Mensah, GA, Meretoja, A, Meretoja, TJ, Mezgebe, HB, Micha, R, Mikesell, J, Miller, TR, Mills, EJ, Minnig, S, Mirarefin, M, Mirrakhimov, EM, Misganaw, A, Mishra, SR, Mohammad, KA, Mohammadi, A, Mohammed, KESM, Mohan, MBV, Mohanty, SK, Mokdad, AH, Assaye, AM, Mollenkopf, SK, Molokhia, M, Monasta, L, Hernandez, JCM, Montico, M, Mooney, MD, Moore, AR, Moradi-Lakeh, M, Moraga, P, Morawska, L, Velasquez, IM, Mori, R, Morrison, SD, Mruts, KB, Mueller, UO, Mullany, E, Muller, K, Venkata, G, Murthy, S, Musa, KI, Nachega, JB, Nagata, C, Nagel, G, Naghavi, M, Naidoo, KS, Nanda, L, Nangia, V, Nascimento, BR, Natarajan, G, Negoi, I, Cuong, TN, Ningrum, DNA, Nisar, MI, Nomura, M, Vuong, MN, Norheim, OF, Norrving, B, Noubiap, JJN, Nyakarahuka, L, Obermeyer, CM, O'Donnell, MJ, Ogbo, FA, Oh, I-H, Okoro, A, Oladimeji, O, Olagunju, AT, Olusanya, BO, Olusanya, JO, Oren, E, Ortiz, A, Osgood-Zimmerman, A, Ota, E, Owolabi, MO, Oyekale, AS, Pa, M, Pacella, RE, Pakhale, S, Pana, A, Panda, BK, Panda-Jonas, S, Park, E-K, Parsaeian, M, Patel, T, Patten, SB, Patton, GC, Paudel, D, Pereira, DM, Perez-Padilla, R, Perez-Ruiz, F, Perico, N, Pervaiz, A, Pesudovs, K, Peterson, CB, Petri, WA, Petzold, M, Phillips, MR, Piel, FB, Pigott, DM, Pishgar, F, Plass, D, Polinder, S, Popova, S, Postma, MJ, Poulton, RG, Pourmalek, F, Prasad, N, Purwar, M, Qorbani, M, Rabiee, RHS, Radfar, A, Rafay, A, Rahimi-Movaghar, A, Rahimi-Movaghar, V, Rahman, M, Rahman, MHU, Rahman, SU, Rai, RK, Rajsic, S, Ram, U, Rana, SM, Ranabhat, CL, Rao, PV, Rawaf, S, Ray, SE, Rego, MAS, Rehm, J, Reiner, RC, Remuzzi, G, Renzaho, AMNN, Resnikoff, S, Rezaei, S, Rezai, MS, Ribeiro, AL, Rokni, MB, Ronfani, L, Roshandel, G, Roth, GA, Rothenbacher, D, Roy, A, Rubagotti, E, Ruhago, GM, Saadat, S, Sabde, YD, Sachdev, PS, Sadat, N, Safdarian, M, Safiri, SSS, Sagar, R, Sahathevan, R, Sahebkar, A, Sahraian, MA, Salama, J, Salamati, P, Salomon, JA, Salvi, SS, Samy, AM, Sanabria, JR, Sanchez-Nino, MD, Santos, IS, Milicevic, MMS, Sarmiento-Suarez, R, Sartorius, B, Satpathy, M, Sawhney, M, Saxena, S, Saylan, MI, Schmidt, MI, Schneider, IJC, Schutte, AE, Schwebel, DC, Schwendicke, F, Seedat, S, Seid, AM, Sepanlou, SG, Servan-Mori, EE, Shackelford, KA, Shaheen, A, Shahraz, S, Shaikh, MA, Shamsipour, M, Shamsizadeh, M, Islam, SMS, Sharma, J, Sharma, R, She, J, Shen, J, Shetty, BP, Shi, P, Shibuya, K, Shigematsu, M, Shiri, R, Shiue, I, Shrime, MG, Sigfusdottir, ID, Silberberg, DH, Silpakit, N, Silva, DAS, Silva, JP, Silveira, DGA, Sindi, S, Singh, A, Singh, JA, Singh, PK, Singh, V, Sinha, DN, Skiadaresi, E, Sligar, A, Smith, DL, Sobaih, BHA, Sobngwi, E, Soneji, S, Soriano, JB, Sreeramareddy, CT, Srinivasan, V, Stathopoulou, V, Steel, N, Stein, DJ, Steiner, C, Stockl, H, Stokes, MA, Strong, M, Sufiyan, MB, Suliankatchi, RA, Sunguya, BF, Sur, PJ, Swaminathan, S, Sykes, BL, Szoeke, CEI, Tabares-Seisdedos, R, Tadakamadla, SK, Tadese, F, Tandon, N, Tanne, D, Tarajia, M, Tavakkoli, M, Taveira, N, Tehrani-Banihashemi, A, Tekelab, T, Tekle, DY, Shifa, GT, Temsah, M-H, Terkawi, AS, Tesema, CL, Tesssema, B, Theis, A, Thomas, N, Thompson, AH, Thomson, AJ, Thrift, AG, Tiruye, TY, Tobe-Gai, R, Tonelli, M, Topor-Madry, R, Topouzis, F, Tortajada, M, Tran, BX, Trujillo, TTU, Tsilimparis, N, Tuem, KB, Tuzcu, EM, Tyrovolas, S, Ukwaja, KN, Undurraga, EA, Uthman, OA, Uzochukwu, BSC, van Boven, JFM, Varakin, YY, Varughese, S, Vasankari, T, Vasconcelos, AMN, Venketasubramanian, N, Vidavalur, R, Violante, FS, Vishnu, A, Vladimirov, SK, Vlassov, VV, Vollset, SE, Vos, T, Waid, JL, Wakayo, T, Wang, Y-P, Weichenthal, S, Weiderpass, E, Weintraub, RG, Werdecker, A, Wesana, J, Wijeratne, T, Wilkinson, JD, Wiysonge, CS, Woldeyes, BG, Wolfe, CDA, Workicho, A, Workie, SB, Xavier, D, Xu, G, Yaghoubi, M, Yakob, B, Yalew, AZ, Yan, LL, Yano, Y, Yaseri, M, Ye, P, Yimam, HH, Yip, P, Yirsaw, BD, Yonemoto, N, Yoon, S-J, Yotebieng, M, Younis, MZ, Zaidi, Z, Zaki, MES, Zeeb, H, Zenebe, ZM, Zerfu, TA, Zhang, AL, Zhang, X, Zodpey, S, Zuhlke, LJ, Lopez, AD, Murray, CJL, Wang, H, Abajobir, AA, Abate, KH, Abbafati, C, Abbas, KM, Abd-Allah, F, Abera, SF, Abraha, HN, Abu-Raddad, LJ, Abu-Rmeileh, NME, Adedeji, IA, Adedoyin, RA, Adetifa, IMO, Adetokunboh, O, Afshin, A, Aggarwal, R, Agrawal, A, Agrawal, S, Kiadaliri, AA, Ahmed, MB, Aichour, AN, Aichour, I, Aichour, MTE, Aiyar, S, Akanda, S, Akinyemiju, TF, Akseer, N, Al-Eyadhy, A, Al Lami, FH, Alabed, S, Alahdab, F, Al-Aly, Z, Alam, K, Alam, N, Alasfoor, D, Aldridge, RW, Alene, KA, Alhabib, S, Ali, R, Alizadeh-Navaei, R, Aljunid, SM, Alkaabi, JM, Alkerwi, A, Alla, F, Allam, SD, Allebeck, P, Al-Raddadi, R, Alsharif, U, Altirkawi, KA, Martin, EA, Alvis-Guzman, N, Amare, AT, Ameh, EA, Amini, E, Ammar, W, Amoako, YA, Anber, N, Andrei, CL, Androudi, S, Ansari, H, Ansha, MG, Antonio, CAT, Anwari, P, Arnlov, J, Arora, M, Al, A, Aryal, KK, Asayesh, H, Asgedom, SW, Asghar, RJ, Assadi, R, Atey, TM, Atre, SR, Avila-Burgos, L, Avokpaho, EFGA, Awasthi, A, Quintanilla, BPA, Babalola, TK, Bacha, U, Badawi, A, Balakrishnan, K, Balalla, S, Barac, A, Barber, RM, Barboza, MA, Barker-Collo, SL, Barnighausen, T, Barquera, S, Barregard, L, Barrero, LH, Baune, BT, Bazargan-Hejazi, S, Bedi, N, Beghi, E, Bejot, Y, Bekele, BB, Bell, ML, Bello, AK, Bennett, DA, Bennett, JR, Bensenor, IM, Benson, J, Berhane, A, Berhe, DF, Bernabe, E, Beuran, M, Beyene, AS, Bhala, N, Bhansali, A, Bhaumik, S, Bhutta, ZA, Bikbov, B, Birungi, C, Biryukov, S, Bisanzio, D, Bizuayehu, HM, Bjerregaard, P, Blosser, CD, Boneya, DJ, Boufous, S, Bourne, RRA, Brazinova, A, Breitborde, NJK, Brenner, H, Brugha, TS, Bukhman, G, Negesa, L, Bulto, B, Bumgarner, BR, Burch, M, Butt, ZA, Cahill, LE, Cahuana-Hurtado, L, Campos-Nonato, IR, Car, J, Car, M, Crdenas, R, Carpenter, DO, Carrero, JJ, Carter, A, Castaneda-Orjuela, CA, Rivas, JC, Castro, FF, Castro, RE, Catala-Lopez, F, Chen, H, Chiang, PP-C, Chibalabala, M, Chisumpa, VH, Chitheer, AA, Choi, J-YJ, Christensen, H, Christopher, DJ, Ciobanu, LG, Cirillo, M, Cohen, AJ, Colquhoun, SM, Coresh, J, Criqui, MH, Cromwell, EA, Crump, JA, Dandona, L, Dandona, R, Dargan, PI, das Neves, J, Davey, G, Davitoiu, DV, Davletov, K, de Courten, B, De Leo, D, Degenhardt, L, Deiparine, S, Dellavalle, RP, Deribe, K, Deribew, A, Des Jarlais, DC, Dey, S, Dharmaratne, SD, Dherani, MK, Diaz-Torne, C, Ding, EL, Dixit, P, Djalalinia, S, Huyen, PD, Doku, DT, Donnelly, CA, Priscila, K, dos Santos, B, Douwes-Schultz, D, Driscoll, TR, Duan, L, Dubey, M, Duncan, BB, Dwivedi, LK, Ebrahimi, H, El Bcheraoui, C, Ellingsen, CL, Enayati, A, Endries, AY, Ermakov, SP, Eshetie, S, Eshrati, B, Eskandarieh, S, Esteghamati, A, Estep, K, Fanuel, BBF, Faro, A, Farvid, MS, Farzadfar, F, Feigin, VL, Fereshtehnejad, S-M, Fernandes, JG, Fernandes, JC, Feyissa, TR, Filip, I, Fischer, F, Foigt, N, Foreman, KJ, Frank, T, Franklin, RC, Fraser, M, Friedman, J, Frostad, JJ, Fullman, N, Furst, T, Furtado, JM, Futran, ND, Gakidou, E, Gambashidze, K, Gamkrelidze, A, Gankpe, FG, Garcia-Basteiro, AL, Gebregergs, GB, Gebrehiwot, TT, Gebrekidan, KG, Gebremichael, MW, Gelaye, AA, Geleijnse, JM, Gemechu, BL, Gemechu, KS, Genova-Maleras, R, Gesesew, HA, Gething, PW, Gibney, KB, Gill, PS, Gillum, RF, Giref, AZ, Girma, BW, Giussani, G, Goenka, S, Gomez, B, Gona, PN, Gopalani, SV, Goulart, AC, Graetz, N, Gugnani, HC, Gupta, PC, Gupta, R, Gupta, T, Gupta, V, Haagsma, JA, Hafezi-Nejad, N, Bidgoli, HH, Hakuzimana, A, Halasa, YA, Hamadeh, RR, Hambisa, MT, Hamidi, S, Hammami, M, Hancock, J, Handal, AJ, Hankey, GJ, Hao, Y, Harb, HL, Hareri, HA, Harikrishnan, S, Haro, JM, Hassanvand, MS, Havmoeller, R, Hay, RJ, Hay, SI, He, F, Heredia-Pi, IB, Herteliu, C, Hilawe, EH, Hoek, HW, Horita, N, Hosgood, HD, Hostiuc, S, Hotez, PJ, Hoy, DG, Hsairi, M, Htet, AS, Hu, G, Huang, H, Huang, JJ, Iburg, KM, Igumbor, EU, Ileanu, BV, Inoue, M, Irenso, AA, Irvine, CMS, Islam, N, Jacobsen, KH, Jaenisch, T, Jahanmehr, N, Jakovljevic, MB, Javanbakht, M, Jayatilleke, AU, Jeemon, P, Jensen, PN, Jha, V, Jin, Y, John, D, John, O, Johnson, SC, Jonas, JB, Jurisson, M, Kabir, Z, Kadel, R, Kahsay, A, Kalkonde, Y, Kamal, R, Kan, H, Karch, A, Karema, CK, Karimi, SM, Karthikeyan, G, Kasaeian, A, Kassaw, NA, Kassebaum, NJ, Kastor, A, Katikireddi, SV, Kaul, A, Kawakami, N, Kazanjan, K, Keiyoro, PN, Kelbore, SG, Kemp, AH, Kengne, AP, Keren, A, Kereselidze, M, Kesavachandran, CN, Ketema, EB, Khader, YS, Khalil, IA, Khan, EA, Khan, G, Khang, Y-H, Khera, S, Khoja, ATA, Khosravi, MH, Kibret, GD, Kieling, C, Kim, C-I, Kim, D, Kim, P, Kim, S, Kim, YJ, Kimokoti, RW, Kinfu, Y, Kishawi, S, Kissimova-Skarbek, KA, Kissoon, N, Kivimaki, M, Knudsen, AK, Kokubo, Y, Kopec, JA, Kosen, S, Koul, PA, Koyanagi, A, Kravchenko, M, Krohn, KJ, Defo, BK, Bicer, BK, Kuipers, EJ, Kulikoff, XR, Kulkarni, VS, Kumar, GA, Kumar, P, Kumsa, FA, Kutz, M, Lachat, C, Lagat, AK, Lager, ACJ, Lal, DK, Lalloo, R, Lambert, N, Lan, Q, Lansingh, VC, Larson, HJ, Larsson, A, Laryea, DO, Lavados, PM, Laxmaiah, A, Lee, PH, Leigh, J, Leung, J, Leung, R, Levi, M, Li, Y, Liao, Y, Liben, ML, Lim, SS, Linn, S, Lipshultz, SE, Liu, S, Lodha, R, Logroscino, G, Lorch, SA, Lorkowski, S, Lotufo, PA, Lozano, R, Lunevicius, R, Lyons, RA, Ma, S, Macarayan, ERK, Machado, IE, Mackay, MT, Abd el Razek, MM, Magis-Rodriguez, C, Mahdavi, M, Majdan, M, Majdzadeh, R, Majeed, A, Malekzadeh, R, Malhotra, R, Malta, DC, Mantovani, LG, Manyazewal, T, Mapoma, CC, Marczak, LB, Marks, GB, Martinez-Raga, J, Martins-Melo, FR, Massano, J, Maulik, PK, Mayosi, BM, Mazidi, M, McAlinden, C, McGarvey, ST, McGrath, JJ, Mckee, M, Mehata, S, Mehndiratta, MM, Mehta, KM, Meier, T, Mekonnen, TC, Meles, KG, Memiah, P, Memish, ZA, Mendoza, W, Mengesha, MM, Mengistie, MA, Tadese, D, Menon, MGR, Menota, BG, Mensah, GA, Meretoja, A, Meretoja, TJ, Mezgebe, HB, Micha, R, Mikesell, J, Miller, TR, Mills, EJ, Minnig, S, Mirarefin, M, Mirrakhimov, EM, Misganaw, A, Mishra, SR, Mohammad, KA, Mohammadi, A, Mohammed, KESM, Mohan, MBV, Mohanty, SK, Mokdad, AH, Assaye, AM, Mollenkopf, SK, Molokhia, M, Monasta, L, Hernandez, JCM, Montico, M, Mooney, MD, Moore, AR, Moradi-Lakeh, M, Moraga, P, Morawska, L, Velasquez, IM, Mori, R, Morrison, SD, Mruts, KB, Mueller, UO, Mullany, E, Muller, K, Venkata, G, Murthy, S, Musa, KI, Nachega, JB, Nagata, C, Nagel, G, Naghavi, M, Naidoo, KS, Nanda, L, Nangia, V, Nascimento, BR, Natarajan, G, Negoi, I, Cuong, TN, Ningrum, DNA, Nisar, MI, Nomura, M, Vuong, MN, Norheim, OF, Norrving, B, Noubiap, JJN, Nyakarahuka, L, Obermeyer, CM, O'Donnell, MJ, Ogbo, FA, Oh, I-H, Okoro, A, Oladimeji, O, Olagunju, AT, Olusanya, BO, Olusanya, JO, Oren, E, Ortiz, A, Osgood-Zimmerman, A, Ota, E, Owolabi, MO, Oyekale, AS, Pa, M, Pacella, RE, Pakhale, S, Pana, A, Panda, BK, Panda-Jonas, S, Park, E-K, Parsaeian, M, Patel, T, Patten, SB, Patton, GC, Paudel, D, Pereira, DM, Perez-Padilla, R, Perez-Ruiz, F, Perico, N, Pervaiz, A, Pesudovs, K, Peterson, CB, Petri, WA, Petzold, M, Phillips, MR, Piel, FB, Pigott, DM, Pishgar, F, Plass, D, Polinder, S, Popova, S, Postma, MJ, Poulton, RG, Pourmalek, F, Prasad, N, Purwar, M, Qorbani, M, Rabiee, RHS, Radfar, A, Rafay, A, Rahimi-Movaghar, A, Rahimi-Movaghar, V, Rahman, M, Rahman, MHU, Rahman, SU, Rai, RK, Rajsic, S, Ram, U, Rana, SM, Ranabhat, CL, Rao, PV, Rawaf, S, Ray, SE, Rego, MAS, Rehm, J, Reiner, RC, Remuzzi, G, Renzaho, AMNN, Resnikoff, S, Rezaei, S, Rezai, MS, Ribeiro, AL, Rokni, MB, Ronfani, L, Roshandel, G, Roth, GA, Rothenbacher, D, Roy, A, Rubagotti, E, Ruhago, GM, Saadat, S, Sabde, YD, Sachdev, PS, Sadat, N, Safdarian, M, Safiri, SSS, Sagar, R, Sahathevan, R, Sahebkar, A, Sahraian, MA, Salama, J, Salamati, P, Salomon, JA, Salvi, SS, Samy, AM, Sanabria, JR, Sanchez-Nino, MD, Santos, IS, Milicevic, MMS, Sarmiento-Suarez, R, Sartorius, B, Satpathy, M, Sawhney, M, Saxena, S, Saylan, MI, Schmidt, MI, Schneider, IJC, Schutte, AE, Schwebel, DC, Schwendicke, F, Seedat, S, Seid, AM, Sepanlou, SG, Servan-Mori, EE, Shackelford, KA, Shaheen, A, Shahraz, S, Shaikh, MA, Shamsipour, M, Shamsizadeh, M, Islam, SMS, Sharma, J, Sharma, R, She, J, Shen, J, Shetty, BP, Shi, P, Shibuya, K, Shigematsu, M, Shiri, R, Shiue, I, Shrime, MG, Sigfusdottir, ID, Silberberg, DH, Silpakit, N, Silva, DAS, Silva, JP, Silveira, DGA, Sindi, S, Singh, A, Singh, JA, Singh, PK, Singh, V, Sinha, DN, Skiadaresi, E, Sligar, A, Smith, DL, Sobaih, BHA, Sobngwi, E, Soneji, S, Soriano, JB, Sreeramareddy, CT, Srinivasan, V, Stathopoulou, V, Steel, N, Stein, DJ, Steiner, C, Stockl, H, Stokes, MA, Strong, M, Sufiyan, MB, Suliankatchi, RA, Sunguya, BF, Sur, PJ, Swaminathan, S, Sykes, BL, Szoeke, CEI, Tabares-Seisdedos, R, Tadakamadla, SK, Tadese, F, Tandon, N, Tanne, D, Tarajia, M, Tavakkoli, M, Taveira, N, Tehrani-Banihashemi, A, Tekelab, T, Tekle, DY, Shifa, GT, Temsah, M-H, Terkawi, AS, Tesema, CL, Tesssema, B, Theis, A, Thomas, N, Thompson, AH, Thomson, AJ, Thrift, AG, Tiruye, TY, Tobe-Gai, R, Tonelli, M, Topor-Madry, R, Topouzis, F, Tortajada, M, Tran, BX, Trujillo, TTU, Tsilimparis, N, Tuem, KB, Tuzcu, EM, Tyrovolas, S, Ukwaja, KN, Undurraga, EA, Uthman, OA, Uzochukwu, BSC, van Boven, JFM, Varakin, YY, Varughese, S, Vasankari, T, Vasconcelos, AMN, Venketasubramanian, N, Vidavalur, R, Violante, FS, Vishnu, A, Vladimirov, SK, Vlassov, VV, Vollset, SE, Vos, T, Waid, JL, Wakayo, T, Wang, Y-P, Weichenthal, S, Weiderpass, E, Weintraub, RG, Werdecker, A, Wesana, J, Wijeratne, T, Wilkinson, JD, Wiysonge, CS, Woldeyes, BG, Wolfe, CDA, Workicho, A, Workie, SB, Xavier, D, Xu, G, Yaghoubi, M, Yakob, B, Yalew, AZ, Yan, LL, Yano, Y, Yaseri, M, Ye, P, Yimam, HH, Yip, P, Yirsaw, BD, Yonemoto, N, Yoon, S-J, Yotebieng, M, Younis, MZ, Zaidi, Z, Zaki, MES, Zeeb, H, Zenebe, ZM, Zerfu, TA, Zhang, AL, Zhang, X, Zodpey, S, Zuhlke, LJ, Lopez, AD, and Murray, CJL

Published
2017

30. Genetic variants of MICB and PLCE1 and associations with the laboratory features of dengue

Author

Whitehorn, J, Duong, THK, Nguyen, THQ, Wills, B, Nguyen, VVC, Dong, THT, Nguyen, MT, Jaenisch, T, Hibberd, M, Chiea, CK, Simmons, CP, Whitehorn, J, Duong, THK, Nguyen, THQ, Wills, B, Nguyen, VVC, Dong, THT, Nguyen, MT, Jaenisch, T, Hibberd, M, Chiea, CK, and Simmons, CP

Abstract

BACKGROUND: A previous genome-wide association study identified 2 susceptibility loci for severe dengue at MICB rs3132468 and PLCE1 rs3740360 and further work showed these mutations to be also associated with less severe clinical presentations. The aim of this study was to determine if these specific loci were associated with laboratory features of dengue that correlate with clinical severity with the aim of elucidating the functional basis of these genetic variants. METHODS: This was a case-only analysis of laboratory-confirmed dengue patients obtained from 2 prospective cohort studies and 1 randomised clinical trial in Vietnam (Trial registration: ISRCTN ISRCTN03147572. Registered 24th July 2012). 2742 dengue cases were successfully genotyped at MICB rs3132468 and PLCE1 rs3740360. Laboratory variables were compared between genotypes and stratified by DENV serotype. RESULTS: The analysis showed no association between MICB and PLCE1 genotype and early viraemia level, platelet nadir, white cell count nadir, or maximum haematocrit in both overall analysis and in analysis stratified by serotype. DISCUSSION: The lack of an association between genotype and viremia level may reflect the sampling procedures within the included studies. The study findings mean that the functional basis of these mutations remains unclear. TRIAL REGISTRATION: ISRCTN ISRCTN03147572 . Registered 24th July 2012.

Published
2017

32. Vascular leakage in dengue - clinical spectrum and influence of parenteral fluid therapy

Author

Rosenberger, K, Lum, L, Alexander, N, Junghanss, T, Wills, B, Jaenisch, T, and Group, DENCO Clinical Study

Subjects
Adult, Male, medicine.medical_specialty, Adolescent, 030231 tropical medicine, Dengue fever, Dengue, Young Adult, 03 medical and health sciences, 0302 clinical medicine, Risk Factors, Internal medicine, medicine, Humans, Prospective Studies, 030212 general & internal medicine, Respiratory system, Young adult, Child, Prospective cohort study, 2. Zero hunger, Respiratory distress, business.industry, Proportional hazards model, Hazard ratio, Infant, Newborn, Public Health, Environmental and Occupational Health, Infant, Shock, Middle Aged, medicine.disease, 3. Good health, Surgery, Infectious Diseases, Child, Preschool, Shock (circulatory), Disease Progression, Blood Vessels, Fluid Therapy, Female, Parasitology, medicine.symptom, business
Abstract

Clinical management of dengue relies on careful monitoring of fluid balance combined with judicious intravenous (IV) fluid therapy. However, in patients with significant vascular leakage IV fluids may aggravate serosal fluid accumulation and result in respiratory distress.Trained physicians followed suspected dengue cases prospectively at seven hospitals across Asia and Latin America, using a comprehensive case-report form that included daily clinical assessment and detailed documentation of parenteral fluid therapy. Applying Cox regression, we evaluated risk factors for the development of shock or respiratory distress with fluid accumulation.Most confirmed-dengue patients (1524/1734, 88%) never experienced dengue shock syndrome (DSS). Among those with DSS, 176/210 (84%) had fluid accumulation, and in the majority, (83%), this was detectable clinically. Among all cases with clinically detectable fluid accumulation, 179/447 (40%) were diagnosed with shock or respiratory distress. The risk for respiratory distress with fluid accumulation increased significantly as the infused volume over the preceding 24hrs increased (hazard ratio 1.18 per 10 ml/kg increase; p

Published
2016

33. Epidemic establishment and cryptic transmission of Zika virus in Brazil and the Americas

Author

Faria, N. R., primary, Quick, J., additional, Morales, I., additional, Thézé, J., additional, Jesus, J.G., additional, Giovanetti, M., additional, Kraemer, M. U. G., additional, Hill, S. C., additional, Black, A., additional, da Costa, A. C., additional, Franco, L.C., additional, Silva, S. P., additional, Wu, C.-H., additional, Raghwani, J., additional, Cauchemez, S., additional, du Plessis, L., additional, Verotti, M. P., additional, de Oliveira, W. K., additional, Carmo, E. H., additional, Coelho, G. E., additional, Santelli, A. C. F. S., additional, Vinhal, L. C., additional, Henriques, C. M., additional, Simpson, J. T., additional, Loose, M., additional, Andersen, K. G., additional, Grubaugh, N. D., additional, Somasekar, S., additional, Chiu, C. Y., additional, Muñoz-Medina, J. E., additional, Gonzalez-Bonilla, C. R., additional, Arias, C. F., additional, Lewis-Ximenez, L. L., additional, Baylis, S.A., additional, Chieppe, A. O., additional, Aguiar, S. F., additional, Fernandes, C. A., additional, Lemos, P. S., additional, Nascimento, B. L. S., additional, Monteiro, H. A. O., additional, Siqueira, I. C., additional, de Queiroz, M. G., additional, de Souza, T. R., additional, Bezerra, J. F., additional, Lemos, M. R., additional, Pereira, G. F., additional, Loudal, D., additional, Moura, L. C., additional, Dhalia, R., additional, França, R. F., additional, Magalhães, T., additional, Marques, E. T., additional, Jaenisch, T., additional, Wallau, G. L., additional, de Lima, M. C., additional, Nascimento, V., additional, de Cerqueira, E. M., additional, de Lima, M. M., additional, Mascarenhas, D. L., additional, Moura Neto, J. P., additional, Levin, A. S., additional, Tozetto-Mendoza, T. R., additional, Fonseca, S. N., additional, Mendes-Correa, M. C., additional, Milagres, F.P., additional, Segurado, A., additional, Holmes, E. C., additional, Rambaut, A., additional, Bedford, T., additional, Nunes, M. R. T., additional, Sabino, E. C., additional, Alcantara, L. C. J., additional, Loman, N., additional, and Pybus, O. G., additional

Published
2017
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34. Mapping global environmental suitability for Zika virus

Author

Messina, JP, Kraemer, MUG, Brady, OJ, Pigott, DM, Shearer, FM, Weiss, DJ, Golding, N, Ruktanonchar, CW, Gething, PW, Cohn, E, Brownstein, JS, Khan, K, Tatem, AJ, Jaenisch, T, Murray, CJL, Marinho, F, Scott, TW, Hay, SI, Messina, JP, Kraemer, MUG, Brady, OJ, Pigott, DM, Shearer, FM, Weiss, DJ, Golding, N, Ruktanonchar, CW, Gething, PW, Cohn, E, Brownstein, JS, Khan, K, Tatem, AJ, Jaenisch, T, Murray, CJL, Marinho, F, Scott, TW, and Hay, SI

Abstract

Zika virus was discovered in Uganda in 1947 and is transmitted by Aedes mosquitoes, which also act as vectors for dengue and chikungunya viruses throughout much of the tropical world. In 2007, an outbreak in the Federated States of Micronesia sparked public health concern. In 2013, the virus began to spread across other parts of Oceania and in 2015, a large outbreak in Latin America began in Brazil. Possible associations with microcephaly and Guillain-Barré syndrome observed in this outbreak have raised concerns about continued global spread of Zika virus, prompting its declaration as a Public Health Emergency of International Concern by the World Health Organization. We conducted species distribution modelling to map environmental suitability for Zika. We show a large portion of tropical and sub-tropical regions globally have suitable environmental conditions with over 2.17 billion people inhabiting these areas.

Published
2016

35. Clinical evaluation of dengue and identification of risk factors for severe disease: protocol for a multicentre study in 8 countries

Author

Jaenisch, T, Dong, THT, Nguyen, TTK, Tran, VN, Nguyen, TN, Nguyen, VK, Yacoub, S, Chanpheaktra, N, Kumar, V, See, LLC, Sathar, J, Sandoval, EP, Maron Alfaro, GM, Laksono, IS, Mahendradhata, Y, Sarker, M, Ahmed, F, Caprara, A, Benevides, BS, Marques, ETA, Magalhaes, T, Brasil, P, Netto, M, Tami, A, Bethencourt, SE, Guzman, M, Simmons, C, Nguyen, THQ, Merson, L, Nguyen, TPD, Beck, D, Wirths, M, Wolbers, M, Phung, KL, Rosenberger, K, Wills, B, Jaenisch, T, Dong, THT, Nguyen, TTK, Tran, VN, Nguyen, TN, Nguyen, VK, Yacoub, S, Chanpheaktra, N, Kumar, V, See, LLC, Sathar, J, Sandoval, EP, Maron Alfaro, GM, Laksono, IS, Mahendradhata, Y, Sarker, M, Ahmed, F, Caprara, A, Benevides, BS, Marques, ETA, Magalhaes, T, Brasil, P, Netto, M, Tami, A, Bethencourt, SE, Guzman, M, Simmons, C, Nguyen, THQ, Merson, L, Nguyen, TPD, Beck, D, Wirths, M, Wolbers, M, Phung, KL, Rosenberger, K, and Wills, B

Abstract

BACKGROUND: The burden of dengue continues to increase globally, with an estimated 100 million clinically apparent infections occurring each year. Although most dengue infections are asymptomatic, patients can present with a wide spectrum of clinical symptoms ranging from mild febrile illness through to severe manifestations of bleeding, organ impairment, and hypovolaemic shock due to a systemic vascular leak syndrome. Clinical diagnosis of dengue and identification of which patients are likely to develop severe disease remain challenging. This study aims to improve diagnosis and clinical management through approaches designed a) to differentiate between dengue and other common febrile illness within 72 h of fever onset, and b) among patients with dengue to identify markers that are predictive of the likelihood of evolving to a more severe disease course. METHOD/DESIGN: This is a prospective multi-centre observational study aiming to enrol 7-8000 participants aged ≥ 5 years presenting with a febrile illness consistent with dengue to outpatient health facilities in 8 countries across Asia and Latin America. Patients presenting within 72 h of fever onset who do not exhibit signs of severe disease are eligible for the study. A broad range of clinical and laboratory parameters are assessed daily for up to 6 days during the acute illness, and also at a follow up visit 1 week later. DISCUSSION: Data from this large cohort of patients, enrolled early with undifferentiated fever, will be used to develop a practical diagnostic algorithm and a robust clinical case definition for dengue. Additionally, among patients with confirmed dengue we aim to identify simple clinical and laboratory parameters associated with progression to a more severe disease course. We will also investigate early virological and serological correlates of severe disease, and examine genetic associations in this large heterogeneous cohort. In addition the results will be used to assess the new World Heal

Published
2016

36. Evidence for a revised dengue classification: a multi-centre prospective study across Southeast Asia and Latin America

Author

Jaenisch, T, Wills, B, Alexander, N, Arana, B, Balmaseda, A, Jr, SJB, Castelobranco, I, Dimaano, E, Farrar, J, Gaczkowski, R, Guzman, M, Harris, E, Hien, TT, Horstick, O, Junghanss, T, Knerer, G, Na-Bangchang, K, Hung, NT, Kalayanarooj, S, Lum, L, Kroeger, A, Martinez Torres, E, Rocha, C, Rosenberger, K, Tan, LH, Thuy, TT, Villalobos, I, and Villegas, E

Published
2009

38. Dogma in Classifying Dengue Disease

Author

Farrar, JJ, Hien, TT, Horstick, O, Hung, NT, Jaenisch, T, Junghanns, T, Kroeger, A, Laksono, IS, Lum, L, Martinez, E, Simmons, CP, Tami, A, Tomashek, KM, Wills, BA, Farrar, JJ, Hien, TT, Horstick, O, Hung, NT, Jaenisch, T, Junghanns, T, Kroeger, A, Laksono, IS, Lum, L, Martinez, E, Simmons, CP, Tami, A, Tomashek, KM, and Wills, BA

Published
2013

39. The global distribution and burden of dengue

Author

Bhatt, S, Gething, PW, Brady, OJ, Messina, JP, Farlow, AW, Moyes, CL, Drake, JM, Brownstein, JS, Hoen, AG, Sankoh, O, Myers, MF, George, DB, Jaenisch, T, Wint, GRW, Simmons, CP, Scott, TW, Farrar, JJ, Hay, SI, Bhatt, S, Gething, PW, Brady, OJ, Messina, JP, Farlow, AW, Moyes, CL, Drake, JM, Brownstein, JS, Hoen, AG, Sankoh, O, Myers, MF, George, DB, Jaenisch, T, Wint, GRW, Simmons, CP, Scott, TW, Farrar, JJ, and Hay, SI

Abstract

Dengue is a systemic viral infection transmitted between humans by Aedes mosquitoes. For some patients, dengue is a life-threatening illness. There are currently no licensed vaccines or specific therapeutics, and substantial vector control efforts have not stopped its rapid emergence and global spread. The contemporary worldwide distribution of the risk of dengue virus infection and its public health burden are poorly known. Here we undertake an exhaustive assembly of known records of dengue occurrence worldwide, and use a formal modelling framework to map the global distribution of dengue risk. We then pair the resulting risk map with detailed longitudinal information from dengue cohort studies and population surfaces to infer the public health burden of dengue in 2010. We predict dengue to be ubiquitous throughout the tropics, with local spatial variations in risk influenced strongly by rainfall, temperature and the degree of urbanization. Using cartographic approaches, we estimate there to be 390 million (95% credible interval 284-528) dengue infections per year, of which 96 million (67-136) manifest apparently (any level of disease severity). This infection total is more than three times the dengue burden estimate of the World Health Organization. Stratification of our estimates by country allows comparison with national dengue reporting, after taking into account the probability of an apparent infection being formally reported. The most notable differences are discussed. These new risk maps and infection estimates provide novel insights into the global, regional and national public health burden imposed by dengue. We anticipate that they will provide a starting point for a wider discussion about the global impact of this disease and will help to guide improvements in disease control strategies using vaccine, drug and vector control methods, and in their economic evaluation.

Published
2013

40. Regarding 'Dengue-How Best to Classify It'

Author

Akbar, NA, Allende, I, Balmaseda, A, Coelho, ICB, da Cunha, RV, Datta, B, Devi, SS, Farrar, J, Gaczkowski, R, Guzman, MG, Harris, E, Hien, TT, Horstick, O, Hung, NT, Jaenisch, T, Junghanss, T, Kroeger, A, Laksono, IS, Lum, LCS, Maron, GM, Martinez, E, Mishra, A, Ooi, EE, Pleites, EB, Ramirez, G, Rosenberger, K, Simmons, CP, Siqueira, JB, Soria, C, Tan, LH, Thuy, TT, Villalobos, I, Villegas, E, Wills, B, Akbar, NA, Allende, I, Balmaseda, A, Coelho, ICB, da Cunha, RV, Datta, B, Devi, SS, Farrar, J, Gaczkowski, R, Guzman, MG, Harris, E, Hien, TT, Horstick, O, Hung, NT, Jaenisch, T, Junghanss, T, Kroeger, A, Laksono, IS, Lum, LCS, Maron, GM, Martinez, E, Mishra, A, Ooi, EE, Pleites, EB, Ramirez, G, Rosenberger, K, Simmons, CP, Siqueira, JB, Soria, C, Tan, LH, Thuy, TT, Villalobos, I, Villegas, E, and Wills, B

Published
2012

41. Multi-Country Evaluation of the Sensitivity and Specificity of Two Commercially-Available NS1 ELISA Assays for Dengue Diagnosis

Author

Powers, AM, Guzman, MG, Jaenisch, T, Gaczkowski, R, Vo, TTH, Sekaran, SD, Kroeger, A, Vazquez, S, Ruiz, D, Martinez, E, Mercado, JC, Balmaseda, A, Harris, E, Dimano, E, Leano, PSA, Yoksan, S, Villegas, E, Benduzu, H, Villalobos, I, Farrar, J, Simmons, CP, Powers, AM, Guzman, MG, Jaenisch, T, Gaczkowski, R, Vo, TTH, Sekaran, SD, Kroeger, A, Vazquez, S, Ruiz, D, Martinez, E, Mercado, JC, Balmaseda, A, Harris, E, Dimano, E, Leano, PSA, Yoksan, S, Villegas, E, Benduzu, H, Villalobos, I, Farrar, J, and Simmons, CP

Abstract

BACKGROUND: Early diagnosis of dengue can assist patient triage and management and prevent unnecessary treatments and interventions. Commercially available assays that detect the dengue virus protein NS1 in the plasma/serum of patients offers the possibility of early and rapid diagnosis. METHODOLOGY/PRINCIPAL FINDINGS: The sensitivity and specificity of the Pan-E Dengue Early ELISA and the Platelia Dengue NS1 Ag assays were compared against a reference diagnosis in 1385 patients in 6 countries in Asia and the Americas. Platelia was more sensitive (66%) than Pan-E (52%) in confirmed dengue cases. Sensitivity varied by geographic region, with both assays generally being more sensitive in patients from SE Asia than the Americas. Both kits were more sensitive for specimens collected within the first few days of illness onset relative to later time points. Pan-E and Platelia were both 100% specific in febrile patients without evidence of acute dengue. In patients with other confirmed diagnoses and healthy blood donors, Platelia was more specific (100%) than Pan-E (90%). For Platelia, when either the NS1 test or the IgM test on the acute sample was positive, the sensitivity versus the reference result was 82% in samples collected in the first four days of fever. NS1 sensitivity was not associated to disease severity (DF or DHF) in the Platelia test, whereas a trend for higher sensitivity in DHF cases was seen in the Pan-E test (however combined with lower overall sensitivity). CONCLUSIONS/SIGNIFICANCE: Collectively, this multi-country study suggests that the best performing NS1 assay (Platelia) had moderate sensitivity (median 64%, range 34-76%) and high specificity (100%) for the diagnosis of dengue. The poor sensitivity of the evaluated assays in some geographical regions suggests further assessments are needed. The combination of NS1 and IgM detection in samples collected in the first few days of fever increased the overall dengue diagnostic sensitivity.

Published
2010

43. Prevalence of post-traumatic stress disorder among Palestinian children and adolescents exposed to political violence: A systematic review and meta-analysis

Author

Nicholas Henschke, Thomas Jaenisch, Volker Winkler, Olaf Horstick, Nisreen Agbaria, Stephanie Petzold, Guido Veronese, Andreas Deckert, Peter Dambach, Agbaria, N, Petzold, S, Deckert, A, Henschke, N, Veronese, G, Dambach, P, Jaenisch, T, Horstick, O, and Winkler, V

Subjects
Male, Epidemiology, PsycINFO, Comorbidity, Cochrane Library, Adolescents, Stress Disorders, Post-Traumatic, Geographical Locations, Families, Mathematical and Statistical Techniques, Adaptation, Psychological, Prevalence, Medicine and Health Sciences, Medicine, Child, Children, education.field_of_study, Multidisciplinary, Politics, Post-Traumatic Stress Disorder, Statistics, Traumatic stress, Metaanalysis, Research Assessment, Anxiety Disorders, Systematic review, Meta-analysis, Physical Sciences, Female, Palestinian Territories, Post-traumatic stress disorder, Adolescents, Children, Palestinian territories, Metaanalysis, Mental health and psychiatry, Systematic reviews, Medical risk factors, Research Article, Risk, medicine.medical_specialty, Sociodemographic Factors, Asia, Adolescent, Systematic Reviews, Science, Population, Context (language use), Neuropsychiatric Disorders, Violence, Neuroses, Research and Analysis Methods, Middle East, Mental Health and Psychiatry, Humans, Statistical Methods, education, business.industry, Public health, Age Groups, Medical Risk Factors, People and Places, Population Groupings, M-PSI/08 - PSICOLOGIA CLINICA, business, Publication Bias, Mathematics, Demography
Abstract

ObjectiveWe undertook a systematic review of the literature to explore the prevalence of post-traumatic stress disorder (PTSD) in Palestinian children and adolescents exposed to political violence. This is the first systematic review and meta-analysis of the prevalence of PTSD in this population.MethodsPubMed, Embase, PsycInfo, Google Scholar and Cochrane library were searched until June 2020. To estimate the prevalence of PTSD, sub-group and meta-analysis were conducted.ResultsThe search resulted in 2786 studies, of which 28 articles representing 32 samples with a total of 15,121 participants from Gaza Strip and West Bank met either the DSM-4 or DSM-5 criteria and were included. The pooled prevalence of PTSD was 36% (95% CI 30–41%;I298.6%) and ranged from 6% to 70%. Sub-group analysis showed that the PTSD prevalence did not differ according to region (West Bank, Gaza Strip) and tended to decrease after including only studies using a representative sample (ppConclusionWe identified high prevalence of PTSD among Palestinian children and adolescents exposed to political violence. However, the pooled results should be interpreted with caution, due to the high heterogeneity and risk of bias in the included studies. These limitations also reflect the challenge in conceptualizing and measuring PTSD in the Palestinian context with a background of continuous and cumulative trauma. Understanding the contextual factors and developing locally adapted survey measures are of relevance to future research, public health planning, and the provision of mental healthcare in Palestine.

Published
2020

44. Global, regional, and national under-5 mortality, adult mortality, age-specific mortality, and life expectancy, 1970–2016: a systematic analysis for the Global Burden of Disease Study 2016

Author

Abajobir, Amanuel Alemu, Abate, Kalkidan Hassen, Abbafati, Cristiana, Abbas, Kaja M., Abd-Allah, Foad, Abera, Semaw Ferede, Abraha, Haftom Niguse, Abu-Raddad, Laith J., Abu-Rmeileh, Niveen M. E., Adedeji, Isaac Akinkunmi, Adedoyin, Rufus Adesoji, Adetifa, Ifedayo Morayo O., Adetokunboh, Olatunji, Afshin, Ashkan, Aggarwal, Rakesh, Agrawal, Anurag, Agrawal, Sutapa, Ahmad Kiadaliri, Aliasghar, Ahmed, Muktar Beshir, Aichour, Miloud Taki Eddine, Aichour, Amani Nidhal, Aichour, Ibthiel, Aiyar, Sneha, Akanda, Ali Shafqat, Akinyemiju, Tomi F., Akseer, Nadia, Al Lami, Faris Hasan, Alabed, Samer, Alahdab, Fares, Al-Aly, Ziyad, Alam, Khurshid, Alam, Noore, Alasfoor, Deena, Aldridge, Robert William, Alene, Kefyalew Addis, Al-Eyadhy, Ayman, Alhabib, Samia, Ali, Raghib, Alizadeh-Navaei, Reza, Aljunid, Syed M., Alkaabi, Juma M., Alkerwi, Ala'a, Alla, François, Allam, Shalini D., Allebeck, Peter, Al-Raddadi, Rajaa, Alsharif, Ubai, Altirkawi, Khalid A., Alvis-Guzman, Nelson, Amare, Azmeraw T., Ameh, Emmanuel A., Amini, Erfan, Ammar, Walid, Amoako, Yaw Ampem, Anber, Nahla, Andrei, Catalina Liliana, Androudi, Sofia, Ansari, Hossein, Ansha, Mustafa Geleto, Antonio, Carl Abelardo T., Anwari, Palwasha, Ärnlöv, Johan, Arora, Megha, Artaman, Al, Aryal, Krishna Kumar, Asayesh, Hamid, Asgedom, Solomon Weldegebreal, Asghar, Rana Jawad, Assadi, Reza, Assaye, Ashagre Molla, Atey, Tesfay Mehari, Atre, Sachin R., Avila-Burgos, Leticia, Avokpaho, Euripide Frinel G. Arthur, Awasthi, Ashish, Babalola, Tesleem Kayode, Bacha, Umar, Badawi, Alaa, Balakrishnan, Kalpana, Balalla, Shivanthi, Barac, Aleksandra, Barber, Ryan M., Barboza, Miguel A., Barker-Collo, Suzanne L., Bärnighausen, Till, Barquera, Simon, Barregard, Lars, Barrero, Lope H., Baune, Bernhard T., Bazargan-Hejazi, Shahrzad, Bedi, Neeraj, Beghi, Ettore, Béjot, Yannick, Bekele, Bayu Begashaw, Bell, Michelle L., Bello, Aminu K., Bennett, Derrick A., Bennett, James R., Bensenor, Isabela M., Benson, Jennifer, Berhane, Adugnaw, Berhe, Derbew Fikadu, Bernabé, Eduardo, Beuran, Mircea, Beyene, Addisu Shunu, Bhala, Neeraj, Bhansali, Anil, Bhaumik, Soumyadeep, Bhutta, Zulfiqar A., Bicer, Burcu Kucuk, Bidgoli, Hassan Haghparast, Bikbov, Boris, Birungi, Charles, Biryukov, Stan, Bisanzio, Donal, Bizuayehu, Habtamu Mellie, Bjerregaard, Peter, Blosser, Christopher D., Boneya, Dube Jara, Boufous, Soufiane, Bourne, Rupert R. A., Brazinova, Alexandra, Breitborde, Nicholas J. K., Brenner, Hermann, Brugha, Traolach S., Bukhman, Gene, Bulto, Lemma Negesa Bulto, Bumgarner, Blair Randal, Burch, Michael, Butt, Zahid A., Cahill, Leah E., Cahuana-Hurtado, Lucero, Campos-Nonato, Ismael Ricardo, Car, Josip, Car, Mate, Cárdenas, Rosario, Carpenter, David O., Carrero, Juan Jesus, Carter, Austin, Castañeda-Orjuela, Carlos A., Castro, Franz F., Castro, Ruben Estanislao, Catalá-López, Ferrán, Chen, Honglei, Chiang, Peggy Pei-Chia, Chibalabala, Mirriam, Chisumpa, Vesper Hichilombwe, Chitheer, Abdulaal A., Choi, Jee-Young Jasmine, Christensen, Hanne, Christopher, Devasahayam Jesudas, Ciobanu, Liliana G., Cirillo, Massimo, Cohen, Aaron J., Colquhoun, Samantha M., Coresh, Josef, Criqui, Michael H., Cromwell, Elizabeth A., Crump, John A., Dandona, Lalit, Dandona, Rakhi, Dargan, Paul I., das Neves, José, Davey, Gail, Davitoiu, Dragos V., Davletov, Kairat, de Courten, Barbora, De Leo, Diego, Degenhardt, Louisa, Deiparine, Selina, Dellavalle, Robert P., Deribe, Kebede, Deribew, Amare, Des Jarlais, Don C., Dey, Subhojit, Dharmaratne, Samath D., Dherani, Mukesh K., Diaz-Torné, Cesar, Ding, Eric L., Dixit, Priyanka, Djalalinia, Shirin, Do, Huyen Phuc, Doku, David Teye, Donnelly, Christl Ann, dos Santos, Kadine Priscila Bender, Douwes-Schultz, Dirk, Driscoll, Tim R., Duan, Leilei, Dubey, Manisha, Duncan, Bruce Bartholow, Dwivedi, Laxmi Kant, Ebrahimi, Hedyeh, El Bcheraoui, Charbel, Ellingsen, Christian Lycke, Enayati, Ahmadali, Endries, Aman Yesuf, Ermakov, Sergey Petrovich, Eshetie, Setegn, Eshrati, Babak, Eskandarieh, Sharareh, Esteghamati, Alireza, Estep, Kara, Fanuel, Fanuel Belayneh Bekele, Faro, André, Farvid, Maryam S., Farzadfar, Farshad, Feigin, Valery L., Fereshtehnejad, Seyed-Mohammad, Fernandes, Jefferson G., Fernandes, João C., Feyissa, Tesfaye Regassa, Filip, Irina, Fischer, Florian, Foigt, Nataliya, Foreman, Kyle J., Frank, Tahvi, Franklin, Richard C., Fraser, Maya, Friedman, Joseph, Frostad, Joseph J., Fullman, Nancy, Fürst, Thomas, Furtado, Joao M., Futran, Neal D., Gakidou, Emmanuela, Gambashidze, Ketevan, Gamkrelidze, Amiran, Gankpé, Fortuné Gbètoho, Garcia-Basteiro, Alberto L., Gebregergs, Gebremedhin Berhe, Gebrehiwot, Tsegaye Tewelde, Gebrekidan, Kahsu Gebrekirstos, Gebremichael, Mengistu Welday, Gelaye, Amha Admasie, Geleijnse, Johanna M., Gemechu, Bikila Lencha, Gemechu, Kasiye Shiferaw, Genova-Maleras, Ricard, Gesesew, Hailay Abrha, Gething, Peter W., Gibney, Katherine B., Gill, Paramjit, Gillum, Richard F., Giref, Ababi Zergaw, Girma, Bedilu Weji, Giussani, Giorgia, Goenka, Shifalika, Gomez, Beatriz, Gona, Philimon N., Gopalani, Sameer Vali, Goulart, Alessandra Carvalho, Graetz, Nicholas, Gugnani, Harish Chander, Gupta, Prakash C., Gupta, Rahul, Gupta, Rajeev, Gupta, Tanush, Gupta, Vipin, Haagsma, Juanita A., Hafezi-Nejad, Nima, Hakuzimana, Alex, Halasa, Yara A., Hamadeh, Randah Ribhi, Hambisa, Mitiku Teshome, Hamidi, Samer, Hammami, Mouhanad, Hancock, Jamie, Handal, Alexis J., Hankey, Graeme J., Hao, Yuantao, Harb, Hilda L., Hareri, Habtamu Abera, Harikrishnan, Sivadasanpillai, Haro, Josep Maria, Hassanvand, Mohammad Sadegh, Havmoeller, Rasmus, Hay, Roderick J., Hay, Simon I., He, Fei, Heredia-Pi, Ileana Beatriz, Herteliu, Claudiu, Hilawe, Esayas Haregot, Hoek, Hans W., Horita, Nobuyuki, Hosgood, H Dean, Hostiuc, Sorin, Hotez, Peter J., Hoy, Damian G., Hsairi, Mohamed, Htet, Aung Soe, Hu, Guoqing, Huang, John J., Huang, Hsiang, Iburg, Kim Moesgaard, Igumbor, Ehimario Uche, Ileanu, Bogdan Vasile, Inoue, Manami, Irenso, Asnake Ararsa, Irvine, Caleb M. S., Islam, Sheikh Mohammed Shariful, Islam, Nazrul, Jacobsen, Kathryn H., Jaenisch, Thomas, Jahanmehr, Nader, Jakovljevic, Mihajlo B., Javanbakht, Mehdi, Jayatilleke, Achala Upendra, Jeemon, Panniyammakal, Jensen, Paul N., Jha, Vivekanand, Jin, Ye, John, Denny, John, Oommen, Johnson, Sarah Charlotte, Jonas, Jost B., Jürisson, Mikk, Kabir, Zubair, Kadel, Rajendra, Kahsay, Amaha, Kalkonde, Yogeshwar, Kamal, Ritul, Kan, Haidong, Karch, André, Karema, Corine Kakizi, Karimi, Seyed M., Karthikeyan, Ganesan, Kasaeian, Amir, Kassaw, Nigussie Assefa, Kassebaum, Nicholas J., Kastor, Anshul, Katikireddi, Srinivasa Vittal, Kaul, Anil, Kawakami, Norito, Kazanjan, Konstantin, Keiyoro, Peter Njenga, Kelbore, Sefonias Getachew, Kemp, Andrew Haddon, Kengne, Andre Pascal, Keren, Andre, Kereselidze, Maia, Kesavachandran, Chandrasekharan Nair, Ketema, Ezra Belay, Khader, Yousef Saleh, Khalil, Ibrahim A., Khan, Ejaz Ahmad, Khan, Gulfaraz, Khang, Young-Ho, Khera, Sahil, Khoja, Abdullah Tawfih Abdullah, Khosravi, Mohammad Hossein, Kibret, Getiye Dejenu, Kieling, Christian, Kim, Yun Jin, Kim, Cho-il, Kim, Daniel, Kim, Pauline, Kim, Sungroul, Kimokoti, Ruth W., Kinfu, Yohannes, Kishawi, Sami, Kissoon, Niranjan, Kivimaki, Mika, Knudsen, Ann Kristin, Kokubo, Yoshihiro, Kopec, Jacek A., Kosen, Soewarta, Koul, Parvaiz A., Koyanagi, Ai, Kravchenko, Michael, Krohn, Kristopher J., Kuate Defo, Barthelemy, Kuipers, Ernst J., Kulikoff, Xie Rachel, Kulkarni, Veena S., Kumar, G. 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Ayala Quintanilla, B, Babalola, T, Bacha, U, Badawi, A, Balakrishnan, K, Balalla, S, Barac, A, Barber, R, Barboza, M, Barker-Collo, S, Bärnighausen, T, Barquera, S, Barregard, L, Barrero, L, Baune, B, Bazargan-Hejazi, S, Bedi, N, Beghi, E, Béjot, Y, Bekele, B, Bell, M, Bello, A, Bennett, D, Bennett, J, Bensenor, I, Benson, J, Berhane, A, Berhe, D, Bernabé, E, Beuran, M, Beyene, A, Bhala, N, Bhansali, A, Bhaumik, S, Bhutta, Z, Bikbov, B, Birungi, C, Biryukov, S, Bisanzio, D, Bizuayehu, H, Bjerregaard, P, Blosser, C, Boneya, D, Boufous, S, Bourne, R, Brazinova, A, Breitborde, N, Brenner, H, Brugha, T, Bukhman, G, Bulto, L, Bumgarner, B, Burch, M, Butt, Z, Cahill, L, Cahuana-Hurtado, L, Campos-Nonato, I, Car, J, Car, M, Cárdenas, R, Carpenter, D, Carrero, J, Carter, A, Castañeda-Orjuela, C, Castillo Rivas, J, Castro, F, Castro, R, Catalá-López, F, Chen, H, Chiang, P, Chibalabala, M, Chisumpa, V, Chitheer, A, Choi, J, Christensen, H, Christopher, D, Ciobanu, L, Cirillo, M, Cohen, A, Colquhoun, S, Coresh, J, Criqui, M, Cromwell, E, Crump, J, Dandona, L, Dandona, R, Dargan, P, Das Neves, J, Davey, G, Davitoiu, D, Davletov, K, De Courten, B, De Leo, D, Degenhardt, L, Deiparine, S, Dellavalle, R, Deribe, K, Deribew, A, Des Jarlais, D, Dey, S, Dharmaratne, S, Dherani, M, Diaz-Torné, C, Ding, E, Dixit, P, Djalalinia, S, Do, H, Doku, D, Donnelly, C, Dos Santos, K, Douwes-Schultz, D, Driscoll, T, Duan, L, Dubey, M, Duncan, B, Dwivedi, L, Ebrahimi, H, El Bcheraoui, C, Ellingsen, C, Enayati, A, Endries, A, Ermakov, S, Eshetie, S, Eshrati, B, Eskandarieh, S, Esteghamati, A, Estep, K, Fanuel, F, Faro, A, Farvid, M, Farzadfar, F, Feigin, V, Fereshtehnejad, S, Fernandes, J, Feyissa, T, Filip, I, Fischer, F, Foigt, N, Foreman, K, Frank, T, Franklin, R, Fraser, M, Friedman, J, Frostad, J, Fullman, N, Fürst, T, Furtado, J, Futran, N, Gakidou, E, Gambashidze, K, Gamkrelidze, A, Gankpé, F, Garcia-Basteiro, A, Gebregergs, G, Gebrehiwot, T, Gebrekidan, K, Gebremichael, M, Gelaye, A, Geleijnse, J, Gemechu, B, Gemechu, K, Genova-Maleras, R, Gesesew, H, Gething, P, Gibney, K, Gill, P, Gillum, R, Giref, A, Girma, B, Giussani, G, Goenka, S, Gomez, B, Gona, P, Gopalani, S, Goulart, A, Graetz, N, Gugnani, H, Gupta, P, Gupta, R, Gupta, T, Gupta, V, Haagsma, J, Hafezi-Nejad, N, Haghparast Bidgoli, H, Hakuzimana, A, Halasa, Y, Hamadeh, R, Hambisa, M, Hamidi, S, Hammami, M, Hancock, J, Handal, A, Hankey, G, Hao, Y, Harb, H, Hareri, H, Harikrishnan, S, Haro, J, Hassanvand, M, Havmoeller, R, Hay, R, Hay, S, He, F, Heredia-Pi, I, Herteliu, C, Hilawe, E, Hoek, H, Horita, N, Hosgood, H, Hostiuc, S, Hotez, P, Hoy, D, Hsairi, M, Htet, A, Hu, G, Huang, H, Huang, J, Iburg, K, Igumbor, E, Ileanu, B, Inoue, M, Irenso, A, Irvine, C, Islam, N, Jacobsen, K, Jaenisch, T, Jahanmehr, N, Jakovljevic, M, Javanbakht, M, Jayatilleke, A, Jeemon, P, Jensen, P, Jha, V, Jin, Y, John, D, John, O, Johnson, S, Jonas, J, Jürisson, M, Kabir, Z, Kadel, R, Kahsay, A, Kalkonde, Y, Kamal, R, Kan, H, Karch, A, Karema, C, Karimi, S, Karthikeyan, G, Kasaeian, A, Kassaw, N, Kassebaum, N, Kastor, A, Katikireddi, S, Kaul, A, Kawakami, N, Kazanjan, K, Keiyoro, P, Kelbore, S, Kemp, A, Kengne, A, Keren, A, Kereselidze, M, Kesavachandran, C, Ketema, E, Khader, Y, Khalil, I, Khan, E, Khan, G, Khang, Y, Khera, S, Khoja, A, Khosravi, M, Kibret, G, Kieling, C, Kim, C, Kim, D, Kim, P, Kim, S, Kim, Y, Kimokoti, R, Kinfu, Y, Kishawi, S, Kissimova-Skarbek, K, Kissoon, N, Kivimaki, M, Knudsen, A, Kokubo, Y, Kopec, J, Kosen, S, Koul, P, Koyanagi, A, Kravchenko, M, Krohn, K, Kuate Defo, B, Kucuk Bicer, B, Kuipers, E, Kulikoff, X, Kulkarni, V, Kumar, G, Kumar, P, Kumsa, F, Kutz, M, Lachat, C, Lagat, A, Lager, A, Lal, D, Lalloo, R, Lambert, N, Lan, Q, Van Lansingh, C, Larson, H, Larsson, A, Laryea, D, Lavados, P, Laxmaiah, A, Lee, P, Leigh, J, Leung, J, Leung, R, Levi, M, Li, Y, Liao, Y, Liben, M, Lim, S, Linn, S, Lipshultz, S, Liu, S, Lodha, R, Logroscino, G, Lorch, S, Lorkowski, S, Lotufo, P, Lozano, R, Lunevicius, R, Lyons, R, Ma, S, Macarayan, E, Machado, I, Mackay, M, Magdy Abd El Razek, M, Magis-Rodriguez, C, Mahdavi, M, Majdan, M, Majdzadeh, R, Majeed, A, Malekzadeh, R, Malhotra, R, Malta, D, Mantovani, L, Manyazewal, T, Mapoma, C, Marczak, L, Marks, G, Martinez-Raga, J, Martins-Melo, F, Massano, J, Maulik, P, Mayosi, B, Mazidi, M, Mcalinden, C, Mcgarvey, S, Mcgrath, J, Mckee, M, Mehata, S, Mehndiratta, M, Mehta, K, Meier, T, Mekonnen, T, Meles, K, Memiah, P, Memish, Z, Mendoza, W, Mengesha, M, Mengistie, M, Mengistu, D, Menon, G, Menota, B, Mensah, G, Meretoja, A, Meretoja, T, Mezgebe, H, Micha, R, Mikesell, J, Miller, T, Mills, E, Minnig, S, Mirarefin, M, Mirrakhimov, E, Misganaw, A, Mishra, S, Mohammad, K, Mohammadi, A, Mohammed, K, Mohammed, S, Mohan, M, Mohanty, S, Mokdad, A, Molla Assaye, A, Mollenkopf, S, Molokhia, M, Monasta, L, Montañez Hernandez, J, Montico, M, Mooney, M, Moore, A, Moradi-Lakeh, M, Moraga, P, Morawska, L, Moreno Velasquez, I, Mori, R, Morrison, S, Mruts, K, Mueller, U, Mullany, E, Muller, K, Murthy, G, Murthy, S, Musa, K, Nachega, J, Nagata, C, Nagel, G, Naghavi, M, Naidoo, K, Nanda, L, Nangia, V, Nascimento, B, Natarajan, G, Negoi, I, Nguyen, C, Nguyen, G, Nguyen, Q, Nguyen, T, Ningrum, D, Nisar, M, Nomura, M, Nong, V, Norheim, O, Norrving, B, Noubiap, J, Nyakarahuka, L, Obermeyer, C, O'Donnell, M, Ogbo, F, Oh, I, Okoro, A, Oladimeji, O, Olagunju, A, Olusanya, B, Olusanya, J, Oren, E, Ortiz, A, Osgood-Zimmerman, A, Ota, E, Owolabi, M, Oyekale, A, Mahesh, P, Pacella, R, Pakhale, S, Pana, A, Panda, B, Panda-Jonas, S, Park, E, Parsaeian, M, Patel, T, Patten, S, Patton, G, Paudel, D, Pereira, D, Perez-Padilla, R, Perez-Ruiz, F, Perico, N, Pervaiz, A, Pesudovs, K, Peterson, C, Petri, W, Petzold, M, Phillips, M, Piel, F, Pigott, D, Pishgar, F, Plass, D, Polinder, S, Popova, S, Postma, M, Poulton, R, Pourmalek, F, Prasad, N, Purwar, M, Qorbani, M, Rabiee, R, Radfar, A, Rafay, A, Rahimi-Movaghar, A, Rahimi-Movaghar, V, Rahman, M, Rahman, S, Rai, R, Rajsic, S, Ram, U, Rana, S, Ranabhat, C, Rao, P, Rawaf, S, Ray, S, Rego, M, Rehm, J, Reiner, R, Remuzzi, G, Renzaho, A, Resnikoff, S, Rezaei, S, Rezai, M, Ribeiro, A, Rokni, M, Ronfani, L, Roshandel, G, Roth, G, Rothenbacher, D, Roy, A, Rubagotti, E, Ruhago, G, Saadat, S, Sabde, Y, Sachdev, P, Sadat, N, Safdarian, M, Safi, S, Safiri, S, Sagar, R, Sahathevan, R, Sahebkar, A, Sahraian, M, Salama, J, Salamati, P, Salomon, J, Salvi, S, Samy, A, Sanabria, J, Sanchez-Niño, M, Santos, I, Santric Milicevic, M, Sarmiento-Suarez, R, Sartorius, B, Satpathy, M, Sawhney, M, Saxena, S, Saylan, M, Schmidt, M, Schneider, I, Schutte, A, Schwebel, D, Schwendicke, F, Seedat, S, Seid, A, Sepanlou, S, Servan-Mori, E, Shackelford, K, Shaheen, A, Shahraz, S, Shaikh, M, Shamsipour, M, Shamsizadeh, M, Islam, S, Sharma, J, Sharma, R, She, J, Shen, J, Shetty, B, Shi, P, Shibuya, K, Shigematsu, M, Shiri, R, Shiue, I, Shrime, M, Sigfusdottir, I, Silberberg, D, Silpakit, N, Silva, D, Silva, J, Silveira, D, Sindi, S, Singh, A, Singh, J, Singh, P, Singh, V, Sinha, D, Skiadaresi, E, Sligar, A, Smith, D, Sobaih, B, Sobngwi, E, Soneji, S, Soriano, J, Sreeramareddy, C, Srinivasan, V, Stathopoulou, V, Steel, N, Stein, D, Steiner, C, Stöckl, H, Stokes, M, Strong, M, Sufiyan, M, Suliankatchi, R, Sunguya, B, Sur, P, Swaminathan, S, Sykes, B, Szoeke, C, Tabarés-Seisdedos, R, Tadakamadla, S, Tadese, F, Tandon, N, Tanne, D, Tarajia, M, Tavakkoli, M, Taveira, N, Tehrani-Banihashemi, A, Tekelab, T, Tekle, D, Temam Shifa, G, Temsah, M, Terkawi, A, Tesema, C, Tesssema, B, Theis, A, Thomas, N, Thompson, A, Thomson, A, Thrift, A, Tiruye, T, Tobe-Gai, R, Tonelli, M, Topor-Madry, R, Topouzis, F, Tortajada, M, Tran, B, Truelsen, T, Trujillo, U, Tsilimparis, N, Tuem, K, Tuzcu, E, Tyrovolas, S, Ukwaja, K, Undurraga, E, Uthman, O, Uzochukwu, B, Van Boven, J, Varakin, Y, Varughese, S, Vasankari, T, Vasconcelos, A, Venketasubramanian, N, Vidavalur, R, Violante, F, Vishnu, A, Vladimirov, S, Vlassov, V, Vollset, S, Vos, T, Waid, J, Wakayo, T, Wang, Y, Weichenthal, S, Weiderpass, E, Weintraub, R, Werdecker, A, Wesana, J, Wijeratne, T, Wilkinson, J, Wiysonge, C, Woldeyes, B, Wolfe, C, Workicho, A, Workie, S, Xavier, D, Xu, G, Yaghoubi, M, Yakob, B, Yalew, A, Yan, L, Yano, Y, Yaseri, M, Ye, P, Yimam, H, Yip, P, Yirsaw, B, Yonemoto, N, Yoon, S, Yotebieng, M, Younis, M, Zaidi, Z, El Sayed Zaki, M, Zeeb, H, Zenebe, Z, Zerfu, T, Zhang, A, Zhang, X, Zodpey, S, Zuhlke, L, Lopez, A, Murray, C, Erasmus MC other, Emergency Medicine, Rehabilitation Medicine, Gastroenterology & Hepatology, Public Health, and Neurology

Subjects
Dánarmein, Heilsufar, Dánartíðni, Lífslíkur, Epidemiology, Aldurshópar, ALCOHOL, Börn, Medicine and Health Sciences, Psychology, DEVELOPING-COUNTRIES, Children, Konur, Ungbörn, Tölfræði, Educational status, Aldraðir, Medicine (all), Global burden of disease/statistics and numerical data, DEATH, Men, Þjóðir, Staðtölur, Stillbirth, Sálfræði, World health, SURVIVAL, Income, CHILD-MORTALITY, HEALTH, Burðarmálsdauði, Infants, Age distribution, HIV infections, Child mortality, Alnæmi, Menntun, GBD, Fæðingartíðni, RUSSIAN MORTALITY, Birth rate, Life Expectancy, SDG 3 - Good Health and Well-being, Women, Mortality, METAANALYSIS, Faraldsfræði, HIV, Frjósemi, Fertility, Socioeconomic Factors, Karlar, Barnadauði, Félagshagfræði, Tekjur, Older people, Cause of death/trends, RA
Abstract

Correction in: Group Author(s): GBD 2016 Mortality Collaborators LANCET Volume: 390 Issue: 10106 Pages: E38-E38 Published: OCT 28 2017, Background Detailed assessments of mortality patterns, particularly age-specific mortality, represent a crucial input that enables health systems to target interventions to specific populations. Understanding how all-cause mortality has changed with respect to development status can identify exemplars for best practice. To accomplish this, the Global Burden of Diseases, Injuries, and Risk Factors Study 2016 (GBD 2016) estimated age-specific and sex-specific all-cause mortality between 1970 and 2016 for 195 countries and territories and at the subnational level for the five countries with a population greater than 200 million in 2016. Methods We have evaluated how well civil registration systems captured deaths using a set of demographic methods called death distribution methods for adults and from consideration of survey and census data for children younger than 5 years. We generated an overall assessment of completeness of registration of deaths by dividing registered deaths in each location-year by our estimate of all-age deaths generated from our overall estimation process. For 163 locations, including subnational units in countries with a population greater than 200 million with complete vital registration (VR) systems, our estimates were largely driven by the observed data, with corrections for small fluctuations in numbers and estimation for recent years where there were lags in data reporting (lags were variable by location, generally between 1 year and 6 years). For other locations, we took advantage of different data sources available to measure under-5 mortality rates (U5MR) using complete birth histories, summary birth histories, and incomplete VR with adjustments; we measured adult mortality rate (the probability of death in individuals aged 15-60 years) using adjusted incomplete VR, sibling histories, and household death recall. We used the U5MR and adult mortality rate, together with crude death rate due to HIV in the GBD model life table system, to estimate age-specific and sex-specific death rates for each location-year. Using various international databases, we identified fatal discontinuities, which we defined as increases in the death rate of more than one death per million, resulting from conflict and terrorism, natural disasters, major transport or technological accidents, and a subset of epidemic infectious diseases; these were added to estimates in the relevant years. In 47 countries with an identified peak adult prevalence for HIV/AIDS of more than 0.5% and where VR systems were less than 65% complete, we informed our estimates of age-sex-specific mortality using the Estimation and Projection Package (EPP)-Spectrum model fitted to national HIV/AIDS prevalence surveys and antenatal clinic serosurveillance systems. We estimated stillbirths, early neonatal, late neonatal, and childhood mortality using both survey and VR data in spatiotemporal Gaussian process regression models. We estimated abridged life tables for all location-years using age-specific death rates. We grouped locations into development quintiles based on the Sociodemographic Index (SDI) and analysed mortality trends by quintile. Using spline regression, we estimated the expected mortality rate for each age-sex group as a function of SDI. We identified countries with higher life expectancy than expected by comparing observed life expectancy to anticipated life expectancy on the basis of development status alone. Findings Completeness in the registration of deaths increased from 28% in 1970 to a peak of 45% in 2013; completeness was lower after 2013 because of lags in reporting. Total deaths in children younger than 5 years decreased from 1970 to 2016, and slower decreases occurred at ages 5-24 years. By contrast, numbers of adult deaths increased in each 5-year age bracket above the age of 25 years. The distribution of annualised rates of change in age-specific mortality rate differed over the period 2000 to 2016 compared with earlier decades: increasing annualised rates of change were less frequent, although rising annualised rates of change still occurred in some locations, particularly for adolescent and younger adult age groups. Rates of stillbirths and under-5 mortality both decreased globally from 1970. Evidence for global convergence of death rates was mixed; although the absolute difference between age-standardised death rates narrowed between countries at the lowest and highest levels of SDI, the ratio of these death rates-a measure of relative inequality-increased slightly. There was a strong shift between 1970 and 2016 toward higher life expectancy, most noticeably at higher levels of SDI. Among countries with populations greater than 1 million in 2016, life expectancy at birth was highest for women in Japan, at 86.9 years (95% UI 86.7-87.2), and for men in Singapore, at 81.3 years (78.8-83.7) in 2016. Male life expectancy was generally lower than female life expectancy between 1970 and 2016, and the gap between male and female life expectancy increased with progression to higher levels of SDI. Some countries with exceptional health performance in 1990 in terms of the difference in observed to expected life expectancy at birth had slower progress on the same measure in 2016. Interpretation Globally, mortality rates have decreased across all age groups over the past five decades, with the largest improvements occurring among children younger than 5 years. However, at the national level, considerable heterogeneity remains in terms of both level and rate of changes in age-specific mortality; increases in mortality for certain age groups occurred in some locations. We found evidence that the absolute gap between countries in age-specific death rates has declined, although the relative gap for some age-sex groups increased. Countries that now lead in terms of having higher observed life expectancy than that expected on the basis of development alone, or locations that have either increased this advantage or rapidly decreased the deficit from expected levels, could provide insight into the means to accelerate progress in nations where progress has stalled., Bill & Melinda Gates Foundation, and the National Institute on Aging and the National Institute of Mental Health of the National Institutes of Health.

Published
2017

45. SARS-CoV-2 seroprevalence screening study of a children's hospital health care workers.

Author

Pluss O, Berman S, Lamb M, Knight V, Roell Y, Berkowitz S, and Jaenisch T

Abstract

Background: Health care workers (HCWs) are front line responders to the COVID-19 pandemic, but limited data is available for pediatric HCWs, as the research response has largely focused on adult patients and medical personnel that treat these patients., Methods: We conducted a cross-sectional study of SARS-CoV-2 seroprevalence and risk factors in HCWs at a Children's Hospital in CO, USA from September 2020 to April 2021. Pediatric HCWs were defined as clinical care providers and administrative staff. Seroprevalence was determined using the Epitope SARS-CoV-2 anti-Nucleocapsid IgG assay (San Diego, CA) and the Euroimmun SARS-CoV-2 anti-Spike Protein IgG assay. Risk factors and vaccination status were assessed via questionnaire., Results: Overall, 110 HCWs were enrolled, 79 subjects were positive for anti-S antibodies and negative for anti-N antibodies, indicating COVID-19 vaccination. 31 subjects had neither anti-N or anti-S antibodies, indicating no exposure to SARS-CoV-2 and no vaccination. 3/110 had a nucleocapsid serology consistent with a SARS-CoV-2 prior infection. Seroprevalence was observed at 2.7%. It was noted that asthma requiring medication was associated with positive serostatus., Conclusions: During the winter 2020/21, SARS-CoV-2, we found a 2.7% seroprevalence of pediatric HCW at a children's hospital in Colorado. We compared this with publicly available seroprevalence data for seroprevalence rates of pediatric HCWs globally. This suggests that this specific children's hospital COVID-19 personal protective equipment (PPE) and infection control guidelines were effective in limiting SARS-CoV-2 in hospital transmission at the children's hospital prior to the presence of the Delta variant., Competing Interests: The author(s) declared no potential conflicts of interest with respect to the research, authorship, and/or publication of this article., (© The Author(s) 2024.)

Published
2024
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46. ArboTracker: a multipathogen dashboard and data platform for arbovirus seroprevalence studies.

Author

Whelan MG, Ware H, Ranka H, Kenny S, Shaikh S, Roell Y, Akter S, Selemon A, Toews E, Chu M, Bobrovitz N, Arora RK, and Jaenisch T

Abstract

Competing Interests: MGW and HW contributed equally as first authors. RKA and TJ are joint final authors. MGW, HW, HR, SK, SS, AS, ET, NB, and RKA report funding for this project from the University of Calgary (Transdisciplinary Connector Grant), Canadian Institutes of Health Research, and the Public Health Agency of Canada (through Canada's COVID-19 Immunity Task Force, 2021-HQ-00056). MGW, HW, HR, SK, SS, AS, ET, NB, and RKA report additional separate funding from the Canadian Medical Association Joule Innovation Fund, WHO, the Robert Koch Institute, and the Food and Agriculture Organization of the United Nations. RKA is employed at OpenAI and receives equity compensation as part of the standard compensation package; RKA was also previously a venture fellow at Flagship Pioneering, minority shareholder of Alethea Medical, and has received funding from the Rhodes Trust and Open Philanthropy. YR, SA, TJ, and MC report funding for this project from European Commission ReCoDID and Contagio grants (EC/825746 and EC/101137283). YR, TJ, and MC report additional funding, unrelated to this project, from the Bill & Melinda Gates Foundation Serosurveillance Grant (GATES/INV-039656) and the Center for Disease Control Air Quality Contract (CDC/75D30123C17606). TJ and SA report funding for this project from the German Research Foundation (grant number 451956976). We thank our talented research team and many alumni of the SeroTracker group, as well as the team working at the Universities of Heidelberg and Colorado. We also thank colleagues at WHO, attendees of the ReCoDID/CONTAGIO meeting held in Heidelberg in 2023, collaborators at the emeritus COVID-19 Immunity Task Force, and colleagues affiliated with the Centre for Health Informatics for helpful discussions. We are also grateful for the support and mentorship of leadership and operations staff at the UCalgary Centre for Health Informatics. This Correspondence does not necessarily reflect the views of WHO or any other funder.

Published
2024
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47. Challenges and Approaches to Establishing Multi-Pathogen Serosurveillance: Findings from the 2023 Serosurveillance Summit.

Author

Carcelen AC, Kong AC, Takahashi S, Hegde S, Jaenisch T, Chu M, Rochford R, Kostandova N, Gurley ES, Wesolowski A, Azman AS, van der Klis FRM, den Hartog G, Drakeley C, Heaney CD, Winter AK, Salje H, Rodriguez-Barraquer I, Leung DT, Njenga SM, Kagucia EW, Jambo KC, Wolter N, Charles RC, Saboyá-Díaz MI, Martin DL, and Moss WJ

Subjects
Humans, Seroepidemiologic Studies, Biosurveillance methods, Communicable Diseases epidemiology, Communicable Diseases immunology
Abstract

Multiplex-based serological surveillance is a valuable but underutilized tool to understand gaps in population-level exposure, susceptibility, and immunity to infectious diseases. Assays for which blood samples can be tested for antibodies against several pathogens simultaneously, such as multiplex bead immunoassays, can more efficiently integrate public health surveillance in low- and middle-income countries. On March 7-8, 2023 a group of experts representing research institutions, multilateral organizations, private industry, and country partners met to discuss experiences, identify challenges and solutions, and create a community of practice for integrated, multi-pathogen serosurveillance using multiplex bead assay technologies. Participants were divided into six working groups: 1) supply chain; 2) laboratory assays; 3) seroepidemiology; 4) data analytics; 5) sustainable implementation; and 6) use case scenarios. These working groups discussed experiences, challenges, solutions, and research needs to facilitate integrated, multi-pathogen serosurveillance for public health. Several solutions were proposed to address challenges that cut across working groups.

Published
2024
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48. Correction: Pooled Cohort Profile: ReCoDID Consortium's Harmonized Acute Febrile Illness Arbovirus Meta-Cohort.

Author

Gómez G, Hufstedler H, Montenegro Morales C, Roell Y, Lozano-Parra A, Tami A, Magalhaes T, Marques ETA, Balmaseda A, Calvet G, Harris E, Brasil P, Herrera V, Villar L, Maxwell L, and Jaenisch T

Abstract

[This corrects the article DOI: 10.2196/54281.]., (©Gustavo Gómez, Heather Hufstedler, Carlos Montenegro Morales, Yannik Roell, Anyela Lozano-Parra, Adriana Tami, Tereza Magalhaes, Ernesto T A Marques, Angel Balmaseda, Guilherme Calvet, Eva Harris, Patricia Brasil, Victor Herrera, Luis Villar, Lauren Maxwell, Thomas Jaenisch, ReCoDID Arbovirus harmonization study group ReCoDID Arbovirus harmonization study group. Originally published in JMIR Public Health and Surveillance (https://publichealth.jmir.org), 30.07.2024.)

Published
2024
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49. Pooled Cohort Profile: ReCoDID Consortium's Harmonized Acute Febrile Illness Arbovirus Meta-Cohort.

Author

Gómez G, Hufstedler H, Montenegro Morales C, Roell Y, Lozano-Parra A, Tami A, Magalhaes T, Marques ETA, Balmaseda A, Calvet G, Harris E, Brasil P, Herrera V, Villar L, Maxwell L, and Jaenisch T

Subjects
Humans, Cohort Studies, Latin America epidemiology, Male, Female, Child, Arboviruses, Retrospective Studies, Adolescent, Child, Preschool, Adult, Arbovirus Infections epidemiology
Abstract

Infectious disease (ID) cohorts are key to advancing public health surveillance, public policies, and pandemic responses. Unfortunately, ID cohorts often lack funding to store and share clinical-epidemiological (CE) data and high-dimensional laboratory (HDL) data long term, which is evident when the link between these data elements is not kept up to date. This becomes particularly apparent when smaller cohorts fail to successfully address the initial scientific objectives due to limited case numbers, which also limits the potential to pool these studies to monitor long-term cross-disease interactions within and across populations. CE data from 9 arbovirus (arthropod-borne viruses) cohorts in Latin America were retrospectively harmonized using the Maelstrom Research methodology and standardized to Clinical Data Interchange Standards Consortium (CDISC). We created a harmonized and standardized meta-cohort that contains CE and HDL data from 9 arbovirus studies from Latin America. To facilitate advancements in cross-population inference and reuse of cohort data, the Reconciliation of Cohort Data for Infectious Diseases (ReCoDID) Consortium harmonized and standardized CE and HDL from 9 arbovirus cohorts into 1 meta-cohort. Interested parties will be able to access data dictionaries that include information on variables across the data sets via Bio Studies. After consultation with each cohort, linked harmonized and curated human cohort data (CE and HDL) will be made accessible through the European Genome-phenome Archive platform to data users after their requests are evaluated by the ReCoDID Data Access Committee. This meta-cohort can facilitate various joint research projects (eg, on immunological interactions between sequential flavivirus infections and for the evaluation of potential biomarkers for severe arboviral disease)., (©Gustavo Gómez, Heather Hufstedler, Carlos Montenegro Morales, Yannik Roell, Anyela Lozano-Parra, Adriana Tami, Tereza Magalhaes, Ernesto T A Marques, Angel Balmaseda, Guilherme Calvet, Eva Harris, Patricia Brasil, Victor Herrera, Luis Villar, Lauren Maxwell, Thomas Jaenisch, ReCoDID Arbovirus harmonization study group. Originally published in JMIR Public Health and Surveillance (https://publichealth.jmir.org), 23.07.2024.)

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2024
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50. Dengue viremia kinetics and effects on platelet count and clinical outcomes: An analysis of 2340 patients from Vietnam.

Author

Vuong NL, Quyen NTH, Tien NTH, Duong Thi Hue K, Duyen HTL, Lam PK, Tam DTH, Van Ngoc T, Jaenisch T, Simmons CP, Yacoub S, Wills BA, and Geskus R

Subjects
Humans, Vietnam epidemiology, Platelet Count, Male, Female, Adult, Kinetics, Middle Aged, Dengue Virus, Young Adult, Adolescent, Viremia blood, Dengue blood, Dengue epidemiology
Abstract

Background: Viremia is a critical factor in understanding the pathogenesis of dengue infection, but limited data exist on viremia kinetics. This study aimed to investigate the kinetics of viremia and its effects on subsequent platelet count, severe dengue, and plasma leakage., Methods: We pooled data from three studies conducted in Vietnam between 2000 and 2016, involving 2340 dengue patients with daily viremia measurements and platelet counts after symptom onset. Viremia kinetics were assessed using a random effects model that accounted for left-censored data. The effects of viremia on subsequent platelet count and clinical outcomes were examined using a landmark approach with a random effects model and logistic regression model with generalized estimating equations, respectively. The rate of viremia decline was derived from the model of viremia kinetics. Its effect on the clinical outcomes was assessed by logistic regression models., Results: Viremia levels rapidly decreased following symptom onset, with variations observed depending on the infecting serotype. DENV-1 exhibited the highest mean viremia levels during the first 5-6 days, while DENV-4 demonstrated the shortest clearance time. Higher viremia levels were associated with decreased subsequent platelet counts from day 6 onwards. Elevated viremia levels on each illness day increased the risk of developing severe dengue and plasma leakage. However, the effect size decreased with later illness days. A more rapid decline in viremia is associated with a reduced risk of the clinical outcomes., Conclusions: This study provides comprehensive insights into viremia kinetics and its effect on subsequent platelet count and clinical outcomes in dengue patients. Our findings underscore the importance of measuring viremia levels during the early febrile phase for dengue studies and support the use of viremia kinetics as outcome for phase-2 dengue therapeutic trials., Funding: Wellcome Trust and European Union Seventh Framework Programme., Competing Interests: NV, NQ, NT, KD, HD, PL, DT, TV, CS, RG No competing interests declared, TJ reports receiving personal fees as members of the Roche Pharmaceuticals Advisory Board on Severe Dengue, outside the submitted work, SY reports receiving personal honorarium for attending the Novartis dengue drug ad board meeting and Takeda dengue education symposium, outside the submitted work, BW reports receiving personal fees (a) as a member of the Roche Advisory Board on Severe Dengue and (b) as a member of the Data Monitoring and Adjudication Committees for the Takeda dengue vaccine trials, both outside the remit of the submitted work, (© 2024, Vuong et al.)

Published
2024
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