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5. Recommandations pour la pratique clinique : prévention de la prématurité spontanée et de ses conséquences (hors rupture des membranes) — Texte des recommandations (texte court)

Author

Sentilhes, L., Sénat, M.-V., Ancel, P.-Y., Azria, E., Benoist, G., Blanc, J., Brabant, G., Bretelle, F., Brun, S., Doret, M., Ducroux-Schouwey, C., Evrard, A., Kayem, G., Maisonneuve, E., Marcellin, L., Marret, S., Mottet, N., Paysant, S., Riethmuller, D., Rozenberg, P., Schmitz, T., Torchin, H., and Langer, B.

Published
2017
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8. The interrelatedness of cognitive abilities in very preterm and full‐term born children at 5.5 years of age: a psychometric network analysis approach.

Author

Rapuc, S., Pierrat, V., Marchand‐Martin, L., Benhammou, V., Kaminski, M., Ancel, P.‐Y., and Twilhaar, E.S.

Subjects
MEMORY, PREMATURE infants, DURATION of pregnancy, INTELLIGIBILITY of speech, COGNITIVE processing speed, CHILD development, SOCIAL network analysis, PSYCHOMETRICS, COMPARATIVE studies, INTELLECT, VERBAL behavior, VISUAL perception, COGNITIVE testing, INTELLIGENCE tests, CHILDREN
Abstract

Background: Very preterm (VP) birth is associated with a considerable risk for cognitive impairment, putting children at a disadvantage in academic and everyday life. Despite lower cognitive ability on the group level, there are large individual differences among VP born children. Contemporary theories define intelligence as a network of reciprocally connected cognitive abilities. Therefore, intelligence was studied as a network of interrelated abilities to provide insight into interindividual differences. We described and compared the network of cognitive abilities, including strength of interrelations between and the relative importance of abilities, of VP and full‐term (FT) born children and VP children with below‐average and average‐high intelligence at 5.5 years. Methods: A total of 2,253 VP children from the EPIPAGE‐2 cohort and 578 FT controls who participated in the 5.5‐year‐follow‐up were eligible for inclusion. The WPPSI‐IV was used to measure verbal comprehension, visuospatial abilities, fluid reasoning, working memory, and processing speed. Psychometric network analysis was applied to analyse the data. Results: Cognitive abilities were densely and positively interconnected in all networks, but the strength of connections differed between networks. The cognitive network of VP children was more strongly interconnected than that of FT children. Furthermore, VP children with below average IQ had a more strongly connected network than VP children with average‐high IQ. Contrary to our expectations, working memory had the least central role in all networks. Conclusions: In line with the ability differentiation hypothesis, children with higher levels of cognitive ability had a less interconnected and more specialised cognitive structure. Composite intelligence scores may therefore mask domain‐specific deficits, particularly in children at risk for cognitive impairments (e.g., VP born children), even when general intelligence is unimpaired. In children with strongly and densely connected networks, domain‐specific deficits may have a larger overall impact, resulting in lower intelligence levels. [ABSTRACT FROM AUTHOR]

Published
2024
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13. Incidence and risk factors of COVID-19-like symptoms in the French general population during the lockdown period: a multi-cohort study.

Author

Carrat, F, Touvier, M, Severi, G, Meyer, L, Jusot, F, Lapidus, N, Rahib, D, Lydié, N, Charles, M-A, Ancel, P-Y, Rouquette, A, de Lamballerie, X, Zins, M, Bajos, N, SAPRIS study group, Carrat, F, Touvier, M, Severi, G, Meyer, L, Jusot, F, Lapidus, N, Rahib, D, Lydié, N, Charles, M-A, Ancel, P-Y, Rouquette, A, de Lamballerie, X, Zins, M, Bajos, N, and SAPRIS study group

Abstract

BACKGROUND: Our main objectives were to estimate the incidence of illnesses presumably caused by SARS-CoV-2 infection during the lockdown period and to identify the associated risk factors. METHODS: Participants from 3 adult cohorts in the general population in France were invited to participate in a survey on COVID-19. The main outcome was COVID-19-Like Symptoms (CLS), defined as a sudden onset of cough, fever, dyspnea, ageusia and/or anosmia, that lasted more than 3 days and occurred during the 17 days before the survey. We used delayed-entry Cox models to identify associated factors. RESULTS: Between April 2, 2020 and May 12, 2020, 279,478 participants were invited, 116,903 validated the questionnaire and 106,848 were included in the analysis. Three thousand thirty-five cases of CLS were reported during 62,099 person-months of follow-up. The cumulative incidences of CLS were 6.2% (95% Confidence Interval (95%CI): 5.7%; 6.6%) on day 15 and 8.8% (95%CI 8.3%; 9.2%) on day 45 of lockdown. The risk of CLS was lower in older age groups and higher in French regions with a high prevalence of SARS-CoV-2 infection, in participants living in cities > 100,000 inhabitants (vs rural areas), when at least one child or adolescent was living in the same household, in overweight or obese people, and in people with chronic respiratory diseases, anxiety or depression or chronic diseases other than diabetes, cancer, hypertension or cardiovascular diseases. CONCLUSION: The incidence of CLS in the general population remained high during the first 2 weeks of lockdown, and decreased significantly thereafter. Modifiable and non-modifiable risk factors were identified.

Published
2021

14. Children's mental and behavioral health, schooling, and socioeconomic characteristics during school closure in France due to COVID-19: the SAPRIS project.

Author

Monnier, M, Moulin, F, Thierry, X, Vandentorren, S, Côté, S, Barbosa, S, Falissard, B, Plancoulaine, S, Charles, M-A, Simeon, T, Geay, B, Marchand, L, Ancel, P-Y, Melchior, M, Rouquette, A, SAPRIS study group, Galera, C, Monnier, M, Moulin, F, Thierry, X, Vandentorren, S, Côté, S, Barbosa, S, Falissard, B, Plancoulaine, S, Charles, M-A, Simeon, T, Geay, B, Marchand, L, Ancel, P-Y, Melchior, M, Rouquette, A, SAPRIS study group, and Galera, C

Abstract

COVID-19 limitation strategies have led to widespread school closures around the world. The present study reports children's mental health and associated factors during the COVID-19 school closure in France in the spring of 2020. We conducted a cross-sectional analysis using data from the SAPRIS project set up during the COVID-19 pandemic in France. Using multinomial logistic regression models, we estimated associations between children's mental health, children's health behaviors, schooling, and socioeconomic characteristics of the children's families. The sample consisted of 5702 children aged 8-9 years, including 50.2% girls. In multivariate logistic regression models, children's sleeping difficulties were associated with children's abnormal symptoms of both hyperactivity-inattention (adjusted Odds Ratio (aOR) 2.05; 95% Confidence Interval 1.70-2.47) and emotional symptoms (aOR 5.34; 95% CI 4.16-6.86). Factors specifically associated with abnormal hyperactivity/inattention were: male sex (aOR 2.29; 95% CI 1.90-2.76), access to specialized care prior to the pandemic and its suspension during school closure (aOR 1.51; 95% CI 1.21-1.88), abnormal emotional symptoms (aOR 4.06; 95% CI 3.11-5.29), being unschooled or schooled with assistance before lockdown (aOR 2.13; 95% CI 1.43-3.17), and tutoring with difficulties or absence of a tutor (aOR 3.25; 95% CI 2.64-3.99; aOR 2.47; 95% CI 1.48-4.11, respectively). Factors associated with children's emotional symptoms were the following: being born pre-term (aOR 1.34; 95% CI 1.03-1.73), COVID-19 cases among household members (aOR 1.72; 95% CI 1.08-2.73), abnormal symptoms of hyperactivity/inattention (aOR 4.18; 95% CI 3.27-5.34) and modest income (aOR 1.45; 95% CI 1.07-1.96; aOR 1.36; 95% CI 1.01-1.84). Multiple characteristics were associated with elevated levels of symptoms of hyperactivity-inattention and emotional symptoms in children during the period of school closure due to COVID-19. Further studies are needed to help

Published
2021

23. Cohort study from 11 European countries highlighted differences in the use and efficacy of hypothermia prevention strategies after very preterm birth

Author

Wilson, Emilija, Zeitlin, Jennifer, Piedvache, Aurélie, Misselwitz, Bjoern, Christensson, Kyllike, Maier, Rolf F., Norman, Mikael, Edstedt Bonamy, Anna Karin, Martens, E., Martens, G., Van Reempts, P., Boerch, K., Hasselager, A., Huusom, L., Pryds, O., Weber, T., Toome, L., Varendi, H., Ancel, P. Y., Blondel, B., Burguet, A., Jarreau, P. H., Truffert, P., Schmidt, S., Gortner, L., Baronciani, D., Gargano, G., Agostino, R., DiLallo, D., Franco, F., Carnielli, V., Cuttini, M., Koopman-Esseboom, C., van Heijst, A., Nijman, J., Gadzinowski, J., Mazela, J., Graça, L. M., Machado, M. C., Rodrigues, C., Rodrigues, T., Barros, H., Boyle, E., Draper, E. S., Manktelow, B. N., Fenton, A. C., Milligan, D. W.A., Bonet, M., Instituto de Saúde Pública, and Intituto de Saúde Pública

Subjects
Male, Hyperthermia, Pediatrics, medicine.medical_specialty, Delivery rooms, Hypothermia prevention, Hypothermia, Cohort Studies, 03 medical and health sciences, 0302 clinical medicine, 030225 pediatrics, Intensive care, medicine, Humans, Very Preterm Birth, Pediatrics, Perinatology, and Child Health, 030212 general & internal medicine, business.industry, European study, Infant, Newborn, Gestational age, General Medicine, medicine.disease, Perinatology, 3. Good health, and Child Health, Europe, Perinatal Care, Pediatrics, Perinatology and Child Health, Hypothermia - Prevention, Gestation, Female, Neonatal intensive care, medicine.symptom, business, Infant, Premature, Very preterm birth, Cohort study
Abstract

Aim: This study investigated the different strategies used in 11 European countries to prevent hypothermia, which continues to affect a large proportion of preterm births in the region. Methods: We examined the association between the reported use of hypothermia prevention strategies in delivery rooms and body temperatures on admission to neonatal intensive care units (NICUs) in 5861 infants born at 22 + 0 to 31 +6 weeks of gestation. The use of plastic bags, wraps, caps, exothermic heat and mattresses was investigated. Results: The proportion of infants born in units that systematically used one or more hypothermia prevention strategies was 88.2% and 50.9% of those infants were hypothermic on admission to NICUs. Of the 9.6% born in units without systematic hypothermia prevention, 73.2% were hypothermic. Only 2.2% of infants were born in units with no reported prevention strategies. Lower gestational age increased the probability of hypothermia. No significant differences were found between the various hypothermia prevention strategies. Hyperthermia was seen in 4.8% of all admitted infants. Conclusion: Very preterm infants had lower risks of hypothermia on NICU admission if the unit used systematic prevention strategies. All the strategies had similar effects, possibly due to implementation rather than a strategy's specific efficacy.

Published
2018

24. Prognostic value of diffusion‐weighted magnetic resonance imaging of brain in fetal growth restriction: results of prospective multicenter study

Author

Jouannic, J. M., primary, Blondiaux, E., additional, Senat, M. V., additional, Friszer, S., additional, Adamsbaum, C., additional, Rousseau, J., additional, Hornoy, P., additional, Letourneau, A., additional, Laveaucoupet, J., additional, Lecarpentier, E., additional, Rosenblatt, J., additional, Quibel, T., additional, Mollot, M., additional, Ancel, P. Y., additional, Alison, M., additional, and Goffinet, F., additional

Published
2020
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25. Propositions sur la prise en charge en cas d’extrême prématurité – Le groupe de travail « Extrême Prématurité » pour la SFMP, le CNGOF et la SFN

Author

Ancel, P.-Y., primary, Breart, G., additional, Bruel, H., additional, Debillon, T., additional, D’Ercole, C., additional, Deruelle, P., additional, Dreyfus, M., additional, Foix-L’Helias, L., additional, Goffinet, F., additional, Jarreau, P.-H., additional, Kuhn, P., additional, Langer, B., additional, Bouvard, C., additional, Evrard, A., additional, Jabert, P., additional, and de Mezerac, I., additional

Published
2020
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31. Wide variation in severe neonatal morbidity among very preterm infants in European regions

Author

Bonamy, Anna Karin Edstedt, Zeitlin, Jennifer, Piedvache, Aurelie, Maier, Rolf F., van Heijst, Arno, Varendi, Heili, Manktelow, Bradley N., Fenton, Alan, Mazela, Jan, Cuttini, Marina, Norman, Mikael, Petrou, Stavros, Van Reempts, Patrick, Barros, Henrique, Draper, Elizabeth S., Martens, E., Martens, G., Van Reempts, P., Boerch, K., Hasselager, A., Huusom, L., Pryds, O., Weber, T., Toome, L., Varendi, H., Ancel, P. Y., Blondel, B., Burguet, A., Jarreau, P. H., Truffert, P., Maier, R. F., Misselwitz, B., Schmidt, S., Gortner, L., Baronciani, D., Gargano, G., Agostino, R., DiLallo, D., Franco, F., Carnielli, V., Koopman-Esseboom, C., Van Heijst, A., Nijman, J., Gadzinowski, J., Mazela, J., Graca, L. M., Machado, M. C., Rodrigues, Carina, Rodrigues, T., Bonamy, A. K., Norman, M., Wilson, E., Boyle, E., Draper, E. S., Manktelow, B. N., Fenton, A. C., Milligan, D. W. A., Zeitlin, J., Bonet, M., Piedvache, A., and Epice Res Grp

Subjects
macromolecular substances, Human medicine
Abstract

Objective To investigate the variation in severe neonatal morbidity among very preterm (VPT) infants across European regions and whether morbidity rates are higher in regions with low compared with high mortality rates. Design Area-based cohort study of all births before 32 weeks of gestational age. Setting 16 regions in 11 European countries in 2011/2012. Patients Survivors to discharge from neonatal care (n=6422). Main outcome measures Severe neonatal morbidity was defined as intraventricular haemorrhage grades III and IV, cystic periventricular leukomalacia, surgical necrotizing enterocolitis and retinopathy of prematurity grades >= 3. A secondary outcome included severe bronchopulmonary dysplasia (BPD), data available in 14 regions. Common definitions for neonatal morbidities were established before data abstraction from medical records. Regional severe neonatal morbidity rates were correlated with regional in-hospital mortality rates for live births after adjustment on maternal and neonatal characteristics. Results 10.6% of survivors had a severe neonatal morbidity without severe BPD (regional range 6.4%23.5%) and 13.8% including severe BPD (regional range 10.0%-23.5%). Adjusted inhospital mortality was 13.7% (regional range 8.4%-18.8%). Differences between regions remained significant after consideration of maternal and neonatal characteristics (P< 0.001) and severe neonatal morbidity rates were not correlated with mortality rates (P= 0.50). Conclusion Severe neonatal morbidity rates for VPT survivors varied widely across European regions and were independent of mortality rates.

Published
2019

32. Wide variation in severe neonatal morbidity among very preterm infants in european regions

Author

Edstedt Bonamy, A-K. (Anna-Karin), Zeitlin, J. (Jennifer), Piedvache, A. (Aurelie), Maier, R.F. (Rolf F.), Van Heijst, A. (Arno), Varendi, H. (Heili), Manktelow, B.N. (Bradley N.), Fenton, A. (Alan), Mazela, J. (Jan), Cuttini, M. (Marina), Norman, M. (Mikael), Petrou, S. (Stavros), Van Reempts, P. (Patrick), Barros, H. (Henrique), Draper, E.S. (Elizabeth S.), Martens, E. (E.), Martens, G. (G.), Boerch, K. (K.), Hasselager, A. (A.), Huusom, L. (L.), Pryds, O. (O.), Weber, T. (Tom), Toome, L. (Liis), Ancel, P-Y. (Pierre-Yves), Blondel, B. (Béatrice), Burguet, A. (Antoine), Jarreau, P-H. (Pierre-Henri), Truffert, P. (Patrick), Schmidt, S. (S.), Gortner, L. (Ludwig), Baronciani, D. (D.), Gargano, G. (G.), Agostino, R. (R.), Dilallo, D. (D.), Franco, F. (F.), Carnielli, V. (V.), Koopman-Esseboom, C. (C.), Nijman, J. (J.), Gadzinowski, J. (Janusz), Graca, L.M. (L. M.), Machado, M.C. (M. C.), Rodrigues, C. (Carina), Rodrigues, T. (T.), Wilson, E. (Emilija), Boyle, E.M. (Eileen Mary), Milligan, D.W.A. (D. W. A.), Bonet, M. (Mercedes), CHU Lille, Université de Lille, Karolinska Institutet [Stockholm], METRICS : Evaluation des technologies de santé et des pratiques médicales - ULR 2694, Centre de Recherche Épidémiologie et Statistique Sorbonne Paris Cité [CRESS (U1153 / UMR_A_1125 / UMR_S_1153)], Radboud University Medical Center [Nijmegen], University of Tartu, University of Leicester, Newcastle University [Newcastle], IRCCS Ospedale Pediatrico Bambino Gesù [Roma], Poznan University of Medical Sciences [Poland] [PUMS], University of Warwick [Coventry], University of Antwerp [UA], Hvidovre Hospital, Université Paris Descartes - Paris 5 [UPD5], CHU Dijon, Evaluation des technologies de santé et des pratiques médicales - ULR 2694 [METRICS], Saarland University [Saarbrücken], Istituto Nazionale di Riposo e Cura per Anziani di Ancona, University Medical Center [Utrecht], Université de Lisbonne, Hospital de São João [Porto], Karolinska University Hospital [Stockholm], and Royal Victoria Hospital

Abstract

OBJECTIVE: To investigate the variation in severe neonatal morbidity among very preterm (VPT) infants across European regions and whether morbidity rates are higher in regions with low compared with high mortality rates. METHODS: Area-based cohort study of all births before 32 weeks of gestational age. METHODS: 16 regions in 11 European countries in 2011/2012. METHODS: Survivors to discharge from neonatal care (n=6422). METHODS: Severe neonatal morbidity was defined as intraventricular haemorrhage grades III and IV, cystic periventricular leukomalacia, surgical necrotizing enterocolitis and retinopathy of prematurity grades ≥3. A secondary outcome included severe bronchopulmonary dysplasia (BPD), data available in 14 regions. Common definitions for neonatal morbidities were established before data abstraction from medical records. Regional severe neonatal morbidity rates were correlated with regional in-hospital mortality rates for live births after adjustment on maternal and neonatal characteristics. RESULTS: 10.6% of survivors had a severe neonatal morbidity without severe BPD (regional range 6.4%-23.5%) and 13.8% including severe BPD (regional range 10.0%-23.5%). Adjusted inhospital mortality was 13.7% (regional range 8.4%-18.8%). Differences between regions remained significant after consideration of maternal and neonatal characteristics (P

Published
2019

33. Early extubation is not associated with severe intraventricular hemorrhage in preterm infants born before 29 weeks of gestation. Results of an EPIPAGE-2 cohort study

Author

Chevallier, M. (Marie), Ancel, P-Y. (Pierre-Yves), Torchin, H. (Heloise), Marchand-Martin, L. (Laetitia), Lorthe, E. (Elsa), Truffert, P. (Patrick), Jarreau, P-H. (Pierre-Henri), Roze, J-C. (Jean-Christophe), Pierrat, V. (Véronique), Marret, S. (Stéphane), Baud, O. (Olivier), Benhammou, V. (Valérie), Ego, A. (Anne), Debillon, T. (Thierry), Techniques pour l'Evaluation et la Modélisation des Actions de la Santé (TIMC-IMAG-ThEMAS), Techniques de l'Ingénierie Médicale et de la Complexité - Informatique, Mathématiques et Applications, Grenoble - UMR 5525 (TIMC-IMAG), Université Joseph Fourier - Grenoble 1 (UJF)-Institut polytechnique de Grenoble - Grenoble Institute of Technology (Grenoble INP)-IMAG-Centre National de la Recherche Scientifique (CNRS)-Université Grenoble Alpes (UGA)-Université Joseph Fourier - Grenoble 1 (UJF)-Institut polytechnique de Grenoble - Grenoble Institute of Technology (Grenoble INP)-IMAG-Centre National de la Recherche Scientifique (CNRS)-Université Grenoble Alpes (UGA), Centre Hospitalier Universitaire [Grenoble] (CHU), Recherche Epidémiologique en Santé Périnatale et Santé des Femmes et des Enfants (UMR_S 953), Institut National de la Santé et de la Recherche Médicale (INSERM)-Université Paris Descartes - Paris 5 (UPD5)-Université Pierre et Marie Curie - Paris 6 (UPMC)-Université Paris-Sud - Paris 11 (UP11), Centre de Recherche Épidémiologie et Statistique Sorbonne Paris Cité (CRESS (U1153 / UMR_A_1125 / UMR_S_1153)), Université Paris Diderot - Paris 7 (UPD7)-Institut National de la Santé et de la Recherche Médicale (INSERM)-Institut National de la Recherche Agronomique (INRA)-Université Paris Descartes - Paris 5 (UPD5)-Université Sorbonne Paris Cité (USPC), Equipe 1 : EPOPé - Épidémiologie Obstétricale, Périnatale et Pédiatrique (CRESS - U1153), Université Paris Diderot - Paris 7 (UPD7)-Institut National de la Santé et de la Recherche Médicale (INSERM)-Institut National de la Recherche Agronomique (INRA)-Université Paris Descartes - Paris 5 (UPD5)-Université Sorbonne Paris Cité (USPC)-Université Paris Diderot - Paris 7 (UPD7)-Institut National de la Santé et de la Recherche Médicale (INSERM)-Institut National de la Recherche Agronomique (INRA)-Université Paris Descartes - Paris 5 (UPD5)-Université Sorbonne Paris Cité (USPC), Service de Médecine Néonatale, Université de Nantes (UN), Team 4 'NeoVasc' - INSERM U1245, Génomique et Médecine Personnalisée du Cancer et des Maladies Neuropsychiatriques (GPMCND), Université de Rouen Normandie (UNIROUEN), Normandie Université (NU)-Normandie Université (NU)-Institut National de la Santé et de la Recherche Médicale (INSERM)-Université de Rouen Normandie (UNIROUEN), Normandie Université (NU)-Normandie Université (NU)-Institut National de la Santé et de la Recherche Médicale (INSERM), Unité de soins intensifs néonatals [AP-HP Hôpital Robert Debré], AP-HP Hôpital universitaire Robert-Debré [Paris], Recherches épidémiologiques en santé périnatale et santé des femmes, Université Pierre et Marie Curie - Paris 6 (UPMC)-Institut National de la Santé et de la Recherche Médicale (INSERM)-Institut National de la Santé et de la Recherche Médicale (INSERM), Registre des Handicaps de l'Enfant et Observatoire Périnatal Isère, RHEOP, Gonzalez, Bruno, Institut polytechnique de Grenoble - Grenoble Institute of Technology (Grenoble INP )-VetAgro Sup - Institut national d'enseignement supérieur et de recherche en alimentation, santé animale, sciences agronomiques et de l'environnement (VAS)-Centre National de la Recherche Scientifique (CNRS)-Université Grenoble Alpes [2016-2019] (UGA [2016-2019])-Institut polytechnique de Grenoble - Grenoble Institute of Technology (Grenoble INP )-VetAgro Sup - Institut national d'enseignement supérieur et de recherche en alimentation, santé animale, sciences agronomiques et de l'environnement (VAS)-Centre National de la Recherche Scientifique (CNRS)-Université Grenoble Alpes [2016-2019] (UGA [2016-2019]), AP-HP - Hôpital Cochin Broca Hôtel Dieu [Paris], Assistance publique - Hôpitaux de Paris (AP-HP) (AP-HP), Université Paris Descartes - Paris 5 (UPD5)-Centre de Recherche Épidémiologie et Statistique Sorbonne Paris Cité (CRESS (U1153 / UMR_A_1125 / UMR_S_1153)), Institut National de la Recherche Agronomique (INRA)-Université Paris Diderot - Paris 7 (UPD7)-Université Paris Descartes - Paris 5 (UPD5)-Université Sorbonne Paris Cité (USPC)-Institut National de la Santé et de la Recherche Médicale (INSERM)-Institut National de la Recherche Agronomique (INRA)-Université Paris Diderot - Paris 7 (UPD7)-Université Sorbonne Paris Cité (USPC)-Institut National de la Santé et de la Recherche Médicale (INSERM), Epidemiology Research Unit [Porto, Portugal] (EPIUnit), Instituto de Saúde Pública [Porto, Portugal], Universidade do Porto = University of Porto-Universidade do Porto = University of Porto, Universidade do Porto = University of Porto, Centre Hospitalier Régional Universitaire [Lille] (CHRU Lille), Maternité Port-Royal [CHU Cochin], Assistance publique - Hôpitaux de Paris (AP-HP) (AP-HP)-Hôpital Cochin [AP-HP], Centre hospitalier universitaire de Nantes (CHU Nantes), CHU Rouen, Normandie Université (NU), Geneva University Hospital (HUG), Université Paris Diderot - Paris 7 (UPD7)-Université Sorbonne Paris Cité (USPC)-Université Paris Descartes - Paris 5 (UPD5)-Institut National de la Santé et de la Recherche Médicale (INSERM)-Institut National de la Recherche Agronomique (INRA)-Université Paris Diderot - Paris 7 (UPD7)-Université Sorbonne Paris Cité (USPC)-Institut National de la Santé et de la Recherche Médicale (INSERM)-Institut National de la Recherche Agronomique (INRA), Universidade do Porto-Universidade do Porto, Universidade do Porto, CHU Lille, Université de Lille, METRICS : Evaluation des technologies de santé et des pratiques médicales - ULR 2694, Techniques pour l'Evaluation et la Modélisation des Actions de la Santé [TIMC-IMAG-ThEMAS], Hôpital Cochin [AP-HP], Equipe 1 : EPOPé - Épidémiologie Obstétricale, Périnatale et Pédiatrique [CRESS - U1153], Evaluation des technologies de santé et des pratiques médicales - ULR 2694 [METRICS], Université Paris Descartes - Paris 5 [UPD5], Centre hospitalier universitaire de Nantes [CHU Nantes], and Hôpitaux Universitaires de Genève [HUG]

Subjects
Critical Care and Emergency Medicine, [SDV]Life Sciences [q-bio], Surfactants, Maternal Health, Pathology and Laboratory Medicine, Vascular Medicine, Pediatrics, Neonatal Care, Cohort Studies, Labor and Delivery, Pregnancy, Risk Factors, Medicine and Health Sciences, Materials, ComputingMilieux_MISCELLANEOUS, ddc:618, Infant, Premature/physiology, Obstetrics and Gynecology, [SDV] Life Sciences [q-bio], Research Design, Physical Sciences, Premature Birth, Medicine, Female, Airway Extubation/adverse effects, Infant, Premature, Premature Birth/pathology, Research Article, Resuscitation, Science, Materials Science, Hemorrhage, Surgical and Invasive Medical Procedures, macromolecular substances, Research and Analysis Methods, Signs and Symptoms, Diagnostic Medicine, Humans, Propensity Score, Cerebral Hemorrhage, Biology and Life Sciences, Neonates, Cerebral Hemorrhage/etiology, Health Care, Airway Extubation, Birth, Women's Health, Neonatology, Intubation, Developmental Biology
Abstract

ObjectiveTo determine whether there is an association between severe intraventricular hemorrhage and early extubation in preterm infants born before 29 weeks of gestational age and intubated at birth.MethodsThis study included 1587 preterm infants from a nationwide French population cohort (EPIPAGE-2). Secondary data on intubated preterm infants were analyzed. After gestational age and propensity score matching (1:1) we built two comparable groups: an early extubation group and a delayed extubation group. Each neonate in one group was paired with a neonate in the other group having the same propensity score and gestational age. Early extubation was defined as extubation within 48 hours of life. Severe intraventricular hemorrhages were defined as grade III or IV hemorrhages according to the Papile classification.ResultsAfter matching, there were 398 neonates in each group. Using a generalized estimating equation model, we found that intraventricular hemorrhage was not associated with early extubation (adjusted OR 0.9, 95%CI 0.6-1.4). This result was supported by sensitivity analyses.ConclusionThe practice of early extubation was not associated with an increased proportion of intraventricular hemorrhages. To complete these results, the long-term neurologic outcomes of these infants need to be assessed.

Published
2019

36. Strategies for assessing the impact of loss to follow-up on estimates of neurodevelopmental impairment in a very preterm cohort at 2 years of age.

Author

Piedvache, Aurélie, van Buuren, Stef, Barros, Henrique, Ribeiro, Ana Isabel, Draper, Elizabeth, Zeitlin, Jennifer, the EPICE Research group, Martens, E., Martens, G., Van Reempts, P., Boerch, K., Hasselager, A., Huusom, L. D., Pryds, O., Weber, T., Toome, L., Varendi, H., France, Ile-de, Ancel, P. Y., and Blondel, B.

Subjects
PREGNANCY complications, GESTATIONAL age, NEURAL development, CONFIDENCE intervals, AGE
Abstract

Background: Loss to follow-up is a major challenge for very preterm (VPT) cohorts; attrition is associated with social disadvantage and parents with impaired children may participate less in research. We investigated the impact of loss to follow-up on the estimated prevalence of neurodevelopmental impairment in a VPT cohort using different methodological approaches.Methods: This study includes births < 32 weeks of gestational age (GA) from 4 regions in the UK and Portugal participating in a European birth cohort (N = 1737 survivors). Data on maternal characteristics, pregnancy complications, neonatal outcomes and neighborhood deprivation were collected at baseline. Neurodevelopment was assessed at 2 years of corrected age (CA) using standardized parent-report measures. We applied (1) multiple imputation (MI) and (2) inverse probability weighting (IPW) to estimate the impact of non-response on the prevalence of moderate to severe neurodevelopmental impairment and assessed violations of the missing at random (MAR) assumption using the delta method.Results: 54.2% of children were followed-up. Follow-up was less likely when mothers were younger, multiparous, foreign-born, did not breastfeed and came from deprived areas. The prevalence of neurodevelopmental impairment was 18.4% (95% confidence interval (CI):15.9-21.1) and increased to 20.4% (95%CI: 17.3-23.4) and 20.0% (95%CI:16.9-23.1) for MI and IPW models, respectively. Simulating strong violations of MAR (children with impairments being 50% less likely to be followed-up) raised estimates to 23.6 (95%CI:20.1-27.1) CONCLUSIONS: In a VPT cohort with high loss to follow-up, correcting for attrition yielded modest increased estimates of neurodevelopmental impairment at 2 years CA; estimates were relatively robust to violations of the MAR assumption. [ABSTRACT FROM AUTHOR]

Published
2021
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38. Cohort study from 11 European countries highlighted differences in the use and efficacy of hypothermia prevention strategies after very preterm birth

Author

MS Neonatologie, Intensive care patientenzorg, Wilson, Emilija, Zeitlin, Jennifer, Piedvache, Aurélie, Misselwitz, Bjoern, Christensson, Kyllike, Maier, Rolf F., Norman, Mikael, Edstedt Bonamy, Anna Karin, Martens, E., Martens, G., Van Reempts, P., Boerch, K., Hasselager, A., Huusom, L., Pryds, O., Weber, T., Toome, L., Varendi, H., Ancel, P. Y., Blondel, B., Burguet, A., Jarreau, P. H., Truffert, P., Schmidt, S., Gortner, L., Baronciani, D., Gargano, G., Agostino, R., DiLallo, D., Franco, F., Carnielli, V., Cuttini, M., Koopman-Esseboom, C., van Heijst, A., Nijman, J., Gadzinowski, J., Mazela, J., Graça, L. M., Machado, M. C., Rodrigues, C., Rodrigues, T., Barros, H., Boyle, E., Draper, E. S., Manktelow, B. N., Fenton, A. C., Milligan, D. W.A., Bonet, M., the EPICE Research Group, MS Neonatologie, Intensive care patientenzorg, Wilson, Emilija, Zeitlin, Jennifer, Piedvache, Aurélie, Misselwitz, Bjoern, Christensson, Kyllike, Maier, Rolf F., Norman, Mikael, Edstedt Bonamy, Anna Karin, Martens, E., Martens, G., Van Reempts, P., Boerch, K., Hasselager, A., Huusom, L., Pryds, O., Weber, T., Toome, L., Varendi, H., Ancel, P. Y., Blondel, B., Burguet, A., Jarreau, P. H., Truffert, P., Schmidt, S., Gortner, L., Baronciani, D., Gargano, G., Agostino, R., DiLallo, D., Franco, F., Carnielli, V., Cuttini, M., Koopman-Esseboom, C., van Heijst, A., Nijman, J., Gadzinowski, J., Mazela, J., Graça, L. M., Machado, M. C., Rodrigues, C., Rodrigues, T., Barros, H., Boyle, E., Draper, E. S., Manktelow, B. N., Fenton, A. C., Milligan, D. W.A., Bonet, M., and the EPICE Research Group

Published
2018

40. Evidence-based neonatal unit practices and determinants of postnatal corticosteroid-use in preterm births below 30 weeks ga in europe. A population-based cohort study

Author

Nuytten, Alexandra, Behal, Hélène, Duhamel, Alain, Jarreau, Pierre Henri, Mazela, Jan, Milligan, David, Gortner, Ludwig, Piedvache, Aurélie, Zeitlin, Jennifer, Truffert, Patrick, Martens, E., Martens, G., Van Reempts, P., Boerch, K., Hasselager, A., Huusom, L., Pryds, O., Weber, T., Toome, L., Varendi, H., Ancel, P. Y., Blondel, B., Burguet, A., Jarreau, P. H., Truffert, P., Maier, R. F., Misselwitz, B., Schmidt, S., Gortner, L., Baronciani, D., Gargano, G., Agostino, R., DiLallo, D., Franco, F., Carnielli, V., Koopman-Esseboom, C., Van Heijst, A., Nijman, J., Gadzinowski, J., Mazela, J., Graça, L. M., Machado, M. C., Rodrigues, T., Barros, H., Bonamy, A. K., Norman, M., Wilson, E., Boyle, E., Draper, E. S., Manktelow, B. N., Fenton, A. C., Milligan, D. W A, Zeitlin, J., Bonet, M., Piedvache, A., CHU Lille, Université de Lille, Santé publique : épidémiologie et qualité des soins - EA 2694, Evaluation des technologies de santé et des pratiques médicales - ULR 2694 [METRICS], METRICS : Evaluation des technologies de santé et des pratiques médicales - ULR 2694, Université Paris Descartes - Paris 5 [UPD5], Poznan University of Medical Sciences [Poland] [PUMS], Newcastle University [Newcastle], Saarland University [Saarbrücken], Centre de Recherche Épidémiologie et Statistique Sorbonne Paris Cité [CRESS (U1153 / UMR_A_1125 / UMR_S_1153)], Equipe 1 : EPOPé - Épidémiologie Obstétricale, Périnatale et Pédiatrique [CRESS - U1153], Evaluation des technologies de santé et des pratiques médicales - ULR 2694 (METRICS), Université de Lille-Centre Hospitalier Régional Universitaire [Lille] (CHRU Lille), Université Paris Descartes - Paris 5 (UPD5), Maternité Port-Royal [CHU Cochin], Assistance publique - Hôpitaux de Paris (AP-HP) (AP-HP)-Hôpital Cochin [AP-HP], Assistance publique - Hôpitaux de Paris (AP-HP) (AP-HP), Poznan University of Medical Sciences [Poland] (PUMS), Centre de Recherche Épidémiologie et Statistique Sorbonne Paris Cité (CRESS (U1153 / UMR_A_1125 / UMR_S_1153)), Institut National de la Recherche Agronomique (INRA)-Université Paris Diderot - Paris 7 (UPD7)-Université Paris Descartes - Paris 5 (UPD5)-Université Sorbonne Paris Cité (USPC)-Institut National de la Santé et de la Recherche Médicale (INSERM), Equipe 1 : EPOPé - Épidémiologie Obstétricale, Périnatale et Pédiatrique (CRESS - U1153), Université Paris Descartes - Paris 5 (UPD5)-Centre de Recherche Épidémiologie et Statistique Sorbonne Paris Cité (CRESS (U1153 / UMR_A_1125 / UMR_S_1153)), Institut National de la Recherche Agronomique (INRA)-Université Paris Diderot - Paris 7 (UPD7)-Université Paris Descartes - Paris 5 (UPD5)-Université Sorbonne Paris Cité (USPC)-Institut National de la Santé et de la Recherche Médicale (INSERM)-Institut National de la Recherche Agronomique (INRA)-Université Paris Diderot - Paris 7 (UPD7)-Université Sorbonne Paris Cité (USPC)-Institut National de la Santé et de la Recherche Médicale (INSERM), and Université de Lille, LillOA

Subjects
Pediatrics, Hydrocortisone, NSAIDs, [SDV]Life Sciences [q-bio], Surfactants, lcsh:Medicine, Neonatal Care, Biochemistry, Geographical Locations, Families, 0302 clinical medicine, MESH: Newborn, MESH: Gestational Age, Medicine and Health Sciences, Data Protection Act 1998, Confidentiality, 030212 general & internal medicine, Lipid Hormones, lcsh:Science, MESH: Cohort Studies, Children, Medicine(all), Analgesics, Multidisciplinary, Agricultural and Biological Sciences(all), Organic Compounds, Drugs, MESH: Infant, 3. Good health, [SDV] Life Sciences [q-bio], Europe, Chemistry, Physical Sciences, Steroids, Infants, Cohort study, Research Article, medicine.medical_specialty, Evidence-based practice, Materials Science, MEDLINE, MESH: Adrenal Cortex Hormones/administration & dosage, Unit (housing), 03 medical and health sciences, 030225 pediatrics, medicine, Journal Article, MESH: Neonatal, Neonatal care, MESH: Premature, Materials by Attribute, Pharmacology, Steroid Hormones, MESH: Humans, business.industry, Biochemistry, Genetics and Molecular Biology(all), lcsh:R, Organic Chemistry, Chemical Compounds, Biology and Life Sciences, Neonates, Pain management, Hormones, Data sharing, Health Care, Data access, Age Groups, Family medicine, People and Places, lcsh:Q, MESH: Intensive Care Units, Population Groupings, MESH: Europe, Neonatology, business, Genetics and Molecular Biology(all), Developmental Biology
Abstract

Correction Published: February 13, 2017 https://doi.org/10.1371/journal.pone.0172408The following information is missing from the Funding section: Funding for this open access publication was provided by the FP7 Post-Grant Open Access Pilot.; BACKGROUND: Postnatal corticosteroids (PNC) were widely used to treat and prevent bronchopulmonary dysplasia in preterm infants until studies showed increased risk of cerebral palsy and neurodevelopmental impairment. We aimed to describe PNC use in Europe and evaluate the determinants of their use, including neonatal characteristics and adherence to evidence-based practices in neonatal intensive care units (NICUs).METHODS: 3917/4096 (95,6%) infants born between 24 and 29 weeks gestational age in 19 regions of 11 European countries of the EPICE cohort we included. We examined neonatal characteristics associated with PNC use. The cohort was divided by tertiles of probability of PNC use determined by logistic regression analysis. We also evaluated the impact of the neonatal unit's reported adherence to European recommendations for respiratory management and a stated policy of reduced PNC use.RESULTS: PNC were prescribed for 545/3917 (13.9%) infants (regional range 3.1-49.4%) and for 29.7% of infants in the highest risk tertile (regional range 5.4-72.4%). After adjustment, independent predictors of PNC use were a low gestational age, small for gestational age, male sex, mechanical ventilation, use of non-steroidal anti-inflammatory drugs to treat persistent ductus arteriosus and region. A stated NICU policy reduced PNC use (odds ratio 0.29 [95% CI 0.17; 0.50]).CONCLUSIONS: PNC are frequently used in Europe, but with wide regional variation that was unexplained by neonatal characteristics. Even for infants at highest risk for PNC use, some regions only rarely prescribed PNC. A stated policy of reduced PNC use was associated with observed practice and is recommended.

Published
2017

41. Use of magnesium sulfate before 32 weeks of gestation : A European population-based cohort study

Author

Wolf, H. T., Huusom, L., Weber, T., Piedvache, A., Schmidt, S., Norman, M., Zeitlin, J., Martens, E., Martens, G., Van Reempts, P., Boerch, K., Hasselager, A., Pryds, O., Toome, L., Varendi, H., Ancel, P. Y., Blondel, B., Burguet, A., Jarreau, P. H., Truffert, P., Maier, R. F., Misselwitz, B., Gortner, L., Baronciani, D., Gargano, G., Agostino, R., DiLallo, D., Franco, F., Carnielli, V., Cuttini, M., Koopman-Esseboom, C., Van Heijst, A., Nijman, J., Gadzinowski, J., Mazela, J., Graça, L. M., MacHado, M. C., Rodrigues, C., Rodrigues, T., Barros, H., Bonamy, A. K., Wilson, E., Boyle, E., Draper, E. S., Manktelow, B. N., Fenton, A. C., Milligan, D. W A, and Bonet, M.

Subjects
Severity of Illness Index, Cohort Studies, 0302 clinical medicine, PREVENTIVE MEDICINE, Pre-Eclampsia, Pregnancy, Obstetrics and Gynaecology, Eclampsia, 030212 general & internal medicine, Practice Patterns, Physicians', reproductive and urinary physiology, Medicine(all), education.field_of_study, 030219 obstetrics & reproductive medicine, Evidence-Based Medicine, Obstetrics, Medical record, General Medicine, Calcium Channel Blockers, female genital diseases and pregnancy complications, 3. Good health, Europe, Pregnancy Trimester, Second, embryonic structures, Population study, Gestation, Premature Birth, Female, Guideline Adherence, Cohort study, Adult, medicine.medical_specialty, HELLP Syndrome, Population, Gestational Age, 03 medical and health sciences, Magnesium Sulfate, Young Adult, Intensive care, medicine, Journal Article, Humans, education, Fetus, business.industry, Research, fungi, medicine.disease, equipment and supplies, business
Abstract

Objectives: The use of magnesium sulfate (MgSO4) in European obstetric units is unknown. We aimed to describe reported policies and actual use of MgSO4 in women delivering before 32 weeks of gestation by indication. Methods: We used data from the European Perinatal Intensive Care in Europe (EPICE) population-based cohort study of births before 32 weeks of gestation in 19 regions in 11 European countries. Data were collected from April 2011 to September 2012 from medical records and questionnaires. The study population comprised 720 women with severe preeclampsia, eclampsia or HELLP and 3658 without preeclampsia delivering from 24 to 31 weeks of gestation in 119 maternity units with 20 or more very preterm deliveries per year. Results: Among women with severe pre-eclampsia, eclampsia or HELLP, 255 (35.4%) received MgSO4 before delivery. 41% of units reported use of MgSO4 whenever possible for pre-eclampsia and administered MgSO4 more often than units reporting use sometimes. In women without pre-eclampsia, 95 (2.6%) received MgSO4. 9 units (7.6%) reported using MgSO4 for fetal neuroprotection whenever possible. In these units, the median rate of MgSO4 use for deliveries without severe pre-eclampsia, eclampsia and HELLP was 14.3%. Only 1 unit reported using MgSO4 as a first-line tocolytic. Among women without preeclampsia, MgSO4 use was not higher in women hospitalised before delivery for preterm labour. Conclusions: Severe pre-eclampsia, eclampsia or HELLP are not treated with MgSO4 as frequently as evidence-based medicine recommends. MgSO4 is seldom used for fetal neuroprotection, and is no longer used for tocolysis. To continuously lower morbidity, greater attention to use of MgSO4 is needed.

Published
2017

42. Neurodevelopment at 2 years and umbilical artery Doppler in cases of very preterm birth after prenatal hypertensive disorder or suspected fetal growth restriction: EPIPAGE-2 prospective population-based cohort study.

Author

Delorme, P., Kayem, G., Lorthe, E., Sentilhes, L., Zeitlin, J., Subtil, D., Rozé, J. C., Vayssière, C., Durox, M., Ancel, P. Y., Pierrat, V., Goffinet, F., Arnaud, Catherine, Blanc, Julie, Boileau, Pascal, Debillon, Thierry, D'Ercole, Claude, Desplanches, Thomas, Diguisto, Caroline, and Foix‐L'Hélias, Laurence

Subjects
UMBILICAL arteries, FETAL growth disorders, PREMATURE labor, NEURAL development, SENSORY disorders, LOGISTIC regression analysis
Abstract

Objective: To investigate the association between absent or reversed end-diastolic flow (ARED) on umbilical artery Doppler ultrasound and poor neurological outcome at 2 years of age after very preterm birth associated with suspected fetal growth restriction (FGR) or maternal hypertensive disorders.Methods: The study population comprised all very preterm (22-31 completed weeks) singleton pregnancies delivered because of suspected FGR and/or maternal hypertensive disorders that had umbilical artery Doppler and 2-year follow-up available included in EPIPAGE-2, a prospective, nationwide, population-based cohort of preterm births in France in 2011. Univariate and two-level multivariable logistic regression analyses were used to assess the association of ARED in the umbilical artery, as compared with normal or reduced end-diastolic flow, with severe or moderate neuromotor and/or sensory disability and with an Ages and Stages Questionnaire (ASQ) score below a threshold. This was defined as a score more than 2 SD below the mean in any of the five domains, at age 2, adjusting for gestational age at delivery. ASQ is used to identify children at risk of developmental delay requiring reinforced follow-up and further evaluation. Descriptive statistics and bivariate tests were weighted according to the duration of the inclusion periods.Results: The analysis included 484 children followed up at 2 years of age, for whom prenatal umbilical artery Doppler ultrasound was available. Among them, 8/484 (1.6%) had severe or moderate neuromotor and/or sensory disability, and 156/342 (45.4%) had an ASQ score below the threshold. Compared with normal or reduced end-diastolic flow in the umbilical artery (n = 305), ARED (n = 179) was associated with severe or moderate neuromotor and/or sensory disability (adjusted odds ratio (OR), 11.3; 95% CI, 1.4-93.2) but not with an ASQ score below the threshold (adjusted OR, 1.2; 95% CI, 0.8-1.9).Conclusion: Among children delivered before 32 weeks of gestation due to suspected FGR and/or maternal hypertensive disorder who survived until 2 years of age, prenatal ARED in the umbilical artery was associated with a higher incidence of severe or moderate neuromotor and/or sensory disability. Copyright © 2020 ISUOG. Published by John Wiley & Sons Ltd. [ABSTRACT FROM AUTHOR]

Published
2020
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43. Efficacy of antenatal corticosteroids in preterm twins: the EPIPAGE-2 cohort study.

Author

Palas, D., Ehlinger, V., Alberge, C., Truffert, P., Kayem, G., Goffinet, F., Ancel, P‐Y, Arnaud, C., Vayssière, C., and Ancel, P-Y

Subjects
CORTICOSTEROIDS, PREMATURE infants, HEALTH outcome assessment, NEWBORN infant health, TWINS, PREMATURE infant disease prevention, BRAIN diseases, BRONCHOPULMONARY dysplasia, COMPARATIVE studies, DRUG administration, PREMATURE infant diseases, INFANT mortality, LONGITUDINAL method, RESEARCH methodology, MEDICAL cooperation, PRENATAL care, RESEARCH, TIME, EVALUATION research, SYMPTOMS, TREATMENT effectiveness, PREVENTION
Abstract

Objectives: To investigate the efficacy of antenatal corticosteroid (ACS) therapy on short-term neonatal outcomes in preterm twins, and further document the influence of the ACS-to-delivery interval.Design: EPIPAGE-2 is a nationwide observational multicentre prospective cohort study of neonates born between 22 and 34 completed weeks of gestation.Setting: All French maternity units, except in a single administrative region, between March and December 2011.Population: A total of 750 twin neonates born between 24 and 31 weeks of gestation.Methods: Exposure to ACSs was examined in four groups: single complete course, with an ACS administration-to-delivery interval of ≤7 days; single complete course, with an ACS-to-delivery interval of >7 days; repeated courses; or no ACS treatment.Main Outcome Measures: Neonatal outcomes analysed were severe bronchopulmonary dysplasia, periventricular leukomalacia or intraventricular haemorrhage grade III/IV, in-hospital mortality, and a composite indicator of severe outcomes.Results: Compared with no ACSs, in multivariable analysis, a single course of ACSs with an administration-to-delivery interval of ≤7 days was significantly associated with a reduced rate of periventricular leukomalacia or intraventricular haemorrhage grade III/IV (aOR 0.2; CI 95% 0.1-0.5), in-hospital mortality (0.3; 0.1-0.6), and the composite indicator (0.1; 0.1-0.3), whereas a single course of ACDs with an administration-to-delivery interval of >7 days did not significantly reduce the frequency of in-hospital mortality (0.7; 0.3-1.8). No significant differences in terms of benefit or risk were found when comparing repeated courses with a single complete course.Conclusion: In preterm twins, a single complete course of antenatal corticosteroids was associated with an improvement of severe neurological outcome, whereas reduced in-hospital mortality was seen only when the ACS-to-delivery interval was ≤7 days.Tweetable Abstract: A single complete course of antenatal steroids reduced severe neurological morbidity in preterm twins (24-31 weeks). [ABSTRACT FROM AUTHOR]

Published
2018
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45. Use of magnesium sulfate before 32 weeks of gestation: A European population-based cohort study

Author

MS Neonatologie, Brain, Arts-assistenten Kinderen, Wolf, H. T., Huusom, L., Weber, T., Piedvache, A., Schmidt, S., Norman, M., Zeitlin, J., Martens, E., Martens, G., Van Reempts, P., Boerch, K., Hasselager, A., Pryds, O., Toome, L., Varendi, H., Ancel, P. Y., Blondel, B., Burguet, A., Jarreau, P. H., Truffert, P., Maier, R. F., Misselwitz, B., Gortner, L., Baronciani, D., Gargano, G., Agostino, R., DiLallo, D., Franco, F., Carnielli, V., Cuttini, M., Koopman-Esseboom, C., Van Heijst, A., Nijman, J., Gadzinowski, J., Mazela, J., Graça, L. M., MacHado, M. C., Rodrigues, C., Rodrigues, T., Barros, H., Bonamy, A. K., Wilson, E., Boyle, E., Draper, E. S., Manktelow, B. N., Fenton, A. C., Milligan, D. W A, Bonet, M., MS Neonatologie, Brain, Arts-assistenten Kinderen, Wolf, H. T., Huusom, L., Weber, T., Piedvache, A., Schmidt, S., Norman, M., Zeitlin, J., Martens, E., Martens, G., Van Reempts, P., Boerch, K., Hasselager, A., Pryds, O., Toome, L., Varendi, H., Ancel, P. Y., Blondel, B., Burguet, A., Jarreau, P. H., Truffert, P., Maier, R. F., Misselwitz, B., Gortner, L., Baronciani, D., Gargano, G., Agostino, R., DiLallo, D., Franco, F., Carnielli, V., Cuttini, M., Koopman-Esseboom, C., Van Heijst, A., Nijman, J., Gadzinowski, J., Mazela, J., Graça, L. M., MacHado, M. C., Rodrigues, C., Rodrigues, T., Barros, H., Bonamy, A. K., Wilson, E., Boyle, E., Draper, E. S., Manktelow, B. N., Fenton, A. C., Milligan, D. W A, and Bonet, M.

Published
2017

46. Evidence-based neonatal unit practices and determinants of Postnatal corticosteroid-use in preterm births below 30 weeks ga in Europe: A population-based cohort study

Author

MS Neonatologie, Brain, Arts-assistenten Kinderen, Nuytten, Alexandra, Behal, Hélène, Duhamel, Alain, Jarreau, Pierre Henri, Mazela, Jan, Milligan, David, Gortner, Ludwig, Piedvache, Aurélie, Zeitlin, Jennifer, Truffert, Patrick, Martens, E., Martens, G., Van Reempts, P., Boerch, K., Hasselager, A., Huusom, L., Pryds, O., Weber, T., Toome, L., Varendi, H., Ancel, P. Y., Blondel, B., Burguet, A., Jarreau, P. H., Truffert, P., Maier, R. F., Misselwitz, B., Schmidt, S., Gortner, L., Baronciani, D., Gargano, G., Agostino, R., DiLallo, D., Franco, F., Carnielli, V., Koopman-Esseboom, C., Van Heijst, A., Nijman, J., Gadzinowski, J., Mazela, J., Graça, L. M., Machado, M. C., Rodrigues, T., Barros, H., Bonamy, A. K., Norman, M., Wilson, E., Boyle, E., Draper, E. S., Manktelow, B. N., Fenton, A. C., Milligan, D. W A, Zeitlin, J., Bonet, M., Piedvache, A., MS Neonatologie, Brain, Arts-assistenten Kinderen, Nuytten, Alexandra, Behal, Hélène, Duhamel, Alain, Jarreau, Pierre Henri, Mazela, Jan, Milligan, David, Gortner, Ludwig, Piedvache, Aurélie, Zeitlin, Jennifer, Truffert, Patrick, Martens, E., Martens, G., Van Reempts, P., Boerch, K., Hasselager, A., Huusom, L., Pryds, O., Weber, T., Toome, L., Varendi, H., Ancel, P. Y., Blondel, B., Burguet, A., Jarreau, P. H., Truffert, P., Maier, R. F., Misselwitz, B., Schmidt, S., Gortner, L., Baronciani, D., Gargano, G., Agostino, R., DiLallo, D., Franco, F., Carnielli, V., Koopman-Esseboom, C., Van Heijst, A., Nijman, J., Gadzinowski, J., Mazela, J., Graça, L. M., Machado, M. C., Rodrigues, T., Barros, H., Bonamy, A. K., Norman, M., Wilson, E., Boyle, E., Draper, E. S., Manktelow, B. N., Fenton, A. C., Milligan, D. W A, Zeitlin, J., Bonet, M., and Piedvache, A.

Published
2017

47. Use of magnesium sulfate before 32 weeks of gestation:A European population-based cohort study

Author

Wolf, H. T., Weber, T., Piedvache, A., Schmidt, S., Norman, M., Zeitlin, J., Martens, E., Martens, G., Van Reempts, P., Boerch, K., Hasselager, A., Huusom, L., Pryds, O., Toome, L., Varendi, H., Ancel, P. Y., Blondel, B., Burguet, A., Jarreau, P. H., Truffert, P., Maier, R. F., Misselwitz, B., Gortner, L., Baronciani, D., Gargano, G., Agostino, R., DiLallo, D., Franco, F., Carnielli, V., Cuttini, M., Koopman-Esseboom, C., Van Heijst, A., Nijman, J., Gadzinowski, J., Mazela, J., Graça, L. M., MacHado, M. C., Rodrigues, C., Rodrigues, T., Barros, H., Bonamy, A. K., Wilson, E., Boyle, E., Draper, E. S., Manktelow, B. N., Fenton, A. C., Wolf, H. T., Weber, T., Piedvache, A., Schmidt, S., Norman, M., Zeitlin, J., Martens, E., Martens, G., Van Reempts, P., Boerch, K., Hasselager, A., Huusom, L., Pryds, O., Toome, L., Varendi, H., Ancel, P. Y., Blondel, B., Burguet, A., Jarreau, P. H., Truffert, P., Maier, R. F., Misselwitz, B., Gortner, L., Baronciani, D., Gargano, G., Agostino, R., DiLallo, D., Franco, F., Carnielli, V., Cuttini, M., Koopman-Esseboom, C., Van Heijst, A., Nijman, J., Gadzinowski, J., Mazela, J., Graça, L. M., MacHado, M. C., Rodrigues, C., Rodrigues, T., Barros, H., Bonamy, A. K., Wilson, E., Boyle, E., Draper, E. S., Manktelow, B. N., and Fenton, A. C.

Abstract

Objectives: The use of magnesium sulfate (MgSO4) in European obstetric units is unknown. We aimed to describe reported policies and actual use of MgSO4 in women delivering before 32 weeks of gestation by indication. Methods: We used data from the European Perinatal Intensive Care in Europe (EPICE) population-based cohort study of births before 32 weeks of gestation in 19 regions in 11 European countries. Data were collected from April 2011 to September 2012 from medical records and questionnaires. The study population comprised 720 women with severe preeclampsia, eclampsia or HELLP and 3658 without preeclampsia delivering from 24 to 31 weeks of gestation in 119 maternity units with 20 or more very preterm deliveries per year. Results: Among women with severe pre-eclampsia, eclampsia or HELLP, 255 (35.4%) received MgSO4 before delivery. 41% of units reported use of MgSO4 whenever possible for pre-eclampsia and administered MgSO4 more often than units reporting use sometimes. In women without pre-eclampsia, 95 (2.6%) received MgSO4. 9 units (7.6%) reported using MgSO4 for fetal neuroprotection whenever possible. In these units, the median rate of MgSO4 use for deliveries without severe pre-eclampsia, eclampsia and HELLP was 14.3%. Only 1 unit reported using MgSO4 as a first-line tocolytic. Among women without preeclampsia, MgSO4 use was not higher in women hospitalised before delivery for preterm labour. Conclusions: Severe pre-eclampsia, eclampsia or HELLP are not treated with MgSO4 as frequently as evidence-based medicine recommends. MgSO4 is seldom used for fetal neuroprotection, and is no longer used for tocolysis. To continuously lower morbidity, greater attention to use of MgSO4 is needed.

Published
2017

50. Recommandations pour la pratique clinique : prévention de la prématurité spontanée et de ses conséquences (hors rupture des membranes) — Texte des recommandations (texte court)

Author

Sentilhes, L., primary, Sénat, M.-V., additional, Ancel, P.-Y., additional, Azria, E., additional, Benoist, G., additional, Blanc, J., additional, Brabant, G., additional, Bretelle, F., additional, Brun, S., additional, Doret, M., additional, Ducroux-Schouwey, C., additional, Evrard, A., additional, Kayem, G., additional, Maisonneuve, E., additional, Marcellin, L., additional, Marret, S., additional, Mottet, N., additional, Paysant, S., additional, Riethmuller, D., additional, Rozenberg, P., additional, Schmitz, T., additional, Torchin, H., additional, and Langer, B., additional

Published
2016
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