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In this paper, we investigate the space-time pointwise behaviors of global solutions to the pressureless Euler-Navier-Stokes system in three dimensions, which characterizes the motion of a twophase fluid. First, we construct the Green's function for the linearized system, which consists of the Huygens wave, the diffusion wave, the Riesz wave, and the singular part containing the stationary delta wave arising from the pressureless structure. Then, under the assumptions on the initial data with appropriate spatial decay rates, we obtain the space-time pointwise estimates of global solutions to the Cauchy problem for the linearized system. [ABSTRACT FROM AUTHOR]

The abnormal concentration of adenosine 5-triphosphate (ATP) in cancer cells is closely related to the process of tumorigenesis and development. Therefore, rapid and accurate detection of ATP level in and out of cells is of great significance. Graphene oxide (GO) is widely used owing to its advantages of low toxicity, large specific surface area, easy functionalization, efficient and stable loading of DNA nanoprobes into cells. However, ssDNA bound to GO by physical adsorption is easily displaced by biomolecules in complex biological environment, leading to false positive signals. Based on this, a novel GO-DNA nanoprobe is proposed and applied to the detection of ATP and targeted delivery of the anticancer drug doxorubicin hydrochloride (DOX). Double stranded DNA (dsDNA) is formed by hybridization of aptamer of ATP with complementary strand, and then DOX is loaded by G-C base pair to form dsDNA-DOX. dsDNA-DOX is adsorbed on GO surface through polyA sequence extended by complementary strand to construct GO-dsDNADOX nanoprobes, which could greatly reduce false positive signal caused by the physical adsorption of biomolecules in complex environment. The specific binding of ATP to aptamer can lead to the release of DOX, and quantitative analysis of ATP is achieved according to its fluorescence “off-on”. DOX fluorescence intensity shows a good linear relationship with the ATP content within the range of 0. 08~8. 0 mmol/L, and the linear equation is IF=3. 0897c+129. 08. The detection limit (3σ/k) is 0. 059 mmol/L, and the method has good selectivity and anti-interference ability. Cytotoxicity and fluorescence imaging results show that the DOXloaded nanoprobes have significant drug release in MCF-7 cells and significantly induce apoptosis. This study establishes a label-free, simple and rapid method for ATP content detection and realizes targeted drug delivery by the high content of ATP in cancer cells, which reduces the toxic and side effects on normal cells and provides a new idea for cancer treatment. [ABSTRACT FROM AUTHOR]

To investigate the soil hydraulic characteristics across a wide range of suctions (0-10 MPa) of Benggang soil, the soil water holding capacities of different soil layers in Benggang was determined using the pressure film meter and the filter paper methods. Traditional and modified Van Genuchten-Mualem (VG) models were used to fit the soil moisture characteristics curves. The results showed that the water-holding curves determined by the pressure film meter and filter paper methods intersected and tended to overlap. This observation suggested combining the two measurement methods to obtain soil moisture characteristic curves over a wide suction range. Further, within the wide suction range, the water-holding capacity of the sandy soil layer was higher than that of the red and detritus soil layers in the low suction stage (h<0.1 MPa). However, in the high suction stage (h>0.1 MPa), the red soil layer had the highest water-holding capacity. Both the traditional and modified VG models were able to fit the soil moisture characteristics of each soil layer of the Benggang wall with a root mean square error of less than 0.021 5. The Nash efficiency and correlation coefficients were greater than 0.926 6 and 0.899 1, respectively. Noticeably, the modified VG model was more suitable for describing the soil moisture characteristic curves of the Benggang wall across a wide suction range. The residual values of the soil moisture characteristic curves for the red, sandy, and detritus layers were 378 kPa (corresponding to a water content of 18.82%), 173 kPa (corresponding to a water content of 18.95%), and 92 kPa (corresponding to a water content of 18.41%), respectively. Finally, the form of the segmental function (with the residual value as the inflection point) was more suitable for describing the unsaturated hydraulic conductivity over a wide suction range of Benggang soils than the conventional VG model. [ABSTRACT FROM AUTHOR]

In this paper, selenated konjac glucomannan (SeKGM) and sulfhydrated sodium al- ginated (TSA) were prepared, following crosslinking using calcium lactate (CL) and obtaining SeKGM-TSA/Ca2+ microgel. Then SeKGM-TSA/Ca2+ @Q was fabricated after querce-tin (Q) loading. Fourier transform infrared spectroscopy (FT-IR) was selected to confirm the chemical structure of microgel, and the morphology of microgel was observed by TEM. The SeKGM-TSA/Ca2+ @Q microgel possessed an uniform spherical morphology with a particle size of 88.8±13. 56 nm. Moreover, OH scavenging rate, mucoadhesion behavior andin vitro Q release behavior of microgel were investigated. the results showed that the · OH scavenging rate of SeKGM-TSA/Ca2+ @Q was 50. 2% +1. 12% and the adhesion to mucin was up to 141.0±0. 46 mg. This work proposed a meaningful strategy for intestinal targeted delivery of Q by using microgel with acidproof. intestinal adhesive properties and ROS scavenging effect. [ABSTRACT FROM AUTHOR]

In the traditional “acetone iodination” experiment, there are problems such as corrosion, irritation caused by HCl volatilization, and inconsistent temperature or time between the spectrophotometric test and the actual reaction process. These problems are inevitably encountered and have not been effectively addressed. With a focus on these problems, the improved experiment presented a colorimetric analysis system based on a smartphone and new glass reactor; the test method was also proposed. The improved experiment avoids instrument corrosion, human body stimulation caused by HCl, improves the accuracy of the experimental data, and is helpful for students to gain theoretical and experimental expertise on the Lambert-Beer law and its offset phenomenon. In addition, since a spectrophotometer is not required, the improved experiment is easier to popularize and more interesting. It also provides a new strategy for online experimental teaching under difficult conditions such as the epidemic. [ABSTRACT FROM AUTHOR]

Objective·To explore the effect of continuous positive urine ketone body in pregnant women with gestational diabetes mellitus (GDM) on the maternal and infant outcomes. Methods·A total of 168 GDM pregnant women who attended the Nutrition Clinic of the International Peace Maternal & Child Health Hospital, Shanghai Jiao Tong University School of Medicine from January 2021 to January 2022 and gave birth in the hospital were selected as the study subjects. According to the difference of urine ketone body test results in prenatal examination, they were divided into ketone body-positive group (56 cases, the pregnant women had ketone body test positive for three times or more after the diagnosis of GDM) and ketone body-negative group (112 cases, the ketone body test was continuously negative after the diagnosis of GDM). The general information included clinical data and laboratory indicators of pregnant women and clinical outcomes of pregnant women and their newborns were collected and compared. Results·There were no statistically significant differences in clinical data and laboratory indicators of pregnant women between the two groups, among which the body mass index before pregnancy, weight change before diagnosis of GDM, family history of diabetes mellitus, history of GDM, total cholesterol and triacylglycerol levels in the early pregnancy, fasting blood glucose and insulin levels in the middle pregnancy had no significant correlation with the production of urine ketone body. The results of clinical outcome indicators of pregnant women showed that there were statistically significant differences in weight change (P= 0.000; RR=6.000, 95% CI 1.251 ‒ 28.777) and rate of weight gain (P=0.000; RR=1.829, 95% CI 1.132 ‒ 2.953) after diagnosis of GDM between the two groups. The results of neonatal clinical outcome indicators showed that there was statistically significant difference in the neonatal hospitalization rate (P=0.023; RR=2.167, 95% CI 1.059 ‒ 4.434) between the two groups; among them, there were 4 adverse events in the ketone body positive group and no such adverse events in the ketone body negative group. Conclusion·The continuous positive urine ketone body of pregnant women with GDM may increase the risk of insufficient weight gain in pregnant women and neonatal hospitalization. It is recommended to timely detect and intervene in clinical practice. [ABSTRACT FROM AUTHOR]

The Ag@AgCl/Bi4Ti3O12photocatalyst was used to treat the methylene blue solution under visible light. The effects of the photocatalyst dosage, the pH value of the wastewater and the photodeposition time on the degradation effect were investigated. The photocatalytic reaction kinetic analysis was performed. The results show that when the photocatalyst dosage is 180 mg, the pH value is 10,and the photodeposition time is 30 min, the degradation effect of 200 mL of 10 mg/L MB solution for 60 min with a 300 W xenon lamp. The photocatalytic decolorization rate reaches 98.96%,the first-order reaction kinetics of the Ag@AgCl/Bi4Ti3O12 catalytic degradation of MB solution under visible light has a good fit value, the surface reaction rate k reaches 0.074 11 min-1,and the half-life t1/2 is 9.35 min, which further proves that Ag@AgCl/Bi4Ti3O12 has better catalytic performance. [ABSTRACT FROM AUTHOR]

Objective To explore the current situation of disease prevention and control ability and training needs of grassroots public health personnel in Luzhou, to provide a reference for improving the disease prevention and control ability of grassroots public health personnel in Luzhou, Methods A questionnaire survey was conducted on 1 075 people engaged in disease control work in township health centers, village clinics, and community health service centers (stations) in Luzhou City to analyze their disease prevention and control ability and influencing factors. Results The average self 一 evaluation score of basic disease prevention and control ability skills of primary public health personnel in Luzhou City was 57. 93 ± 27. 30 points, with a score rate of 46. 72%. Among them, r prevention and control of chronic non - communicable diseasesir had the highest score rate of 56. 94%, and, r prevention and control of endemic and parasitic diseases" had the lowest score rate of 37. 75%. Among the survey respondents, 92.37% had participated in basic knowledge or skills training in disease control, and the proportion of those who chose, r on - site guidance1 r as the desired form of training was the highest, at 80. 74%. The results of multiple linear regression analysis showed that the factors affecting the ability of primary public health personnel in disease prevention and control were mainly female(£ 二-3. 425, P = 0. 001), outside the establishment(£ 二 3. 322, P = 0. 001), not having participated in training in basic knowledge or skills of disease control(£ 二 -6. 119, P < 0.001), professional background (non 一 medical t - -2. 083, P = 0. 038) and professional background (non 一 medical £ 二 一 0. 083, P = 0. 038). Conclusion The disease prevention and control ability of grassroots public health personnel in Luzhou City is relatively weak, with gender, professional background, establishment, and whether they have participated in training being the main influencing factors, requiring targeted training in relevant knowledge and skills. [ABSTRACT FROM AUTHOR]

Using our team's recent research achievement “the cervical ultrasound scanning route map” as a teaching tool, to evaluate its impact on the learning effectiveness and confidence of beginners in the process of learning cervical spinal ultrasonography. Methods This study is a before and after self-control study. After recruitment of 40 cervical ultrasound beginners, they had completed questionnaire 1. The questionnaire was designed with three self-assessment questions on theoretical knowledge of cervical spinal ultrasound, three self-assessment questions on practical skills of cervical spinal ultrasound and one question on willingness to use cervical spinal ultrasound in the future. After traditional teaching without involving the route map, beginners completed questionnaire 2 with the same content. After a 20 min break, teacher introduced and explained the route map to the beginners, then the beginners completed questionnaire 3. Questions related to satisfaction with this learning experience had been added to questionnaire 3. The answers to all questions were scored on a scale of 1-10. In this study, the main outcome was the comprehensive learning score, calculated as(sum score of theoretical knowledge + sum score of practical skills + score of willingness to use cervical ultrasound in the future)/7. Results Beginners'comprehensive learning score at the three time points were 2.9±1.3, 4.8±1.8, 5.7±1.8,F(2,22)=52.11,P＜0.001,partial Eta squared=0.83. After introducing the route map, their comprehensive learning score increased 1.0(95% CI:0.46-1.49)(P＜0.001) compared to scores after traditional training. Conclusions The route map may significantly improve learning effectiveness and confidence of beginners in the field of cervical spinal ultrasonography and can be used as a routine training tool in the teaching of cervical spinal ultrasonography. [ABSTRACT FROM AUTHOR]

Objective To construct the galactose（Gal） and polyethyleneimine（PEI）-modified magnetic nanocarriers（Gal-PEI-SPIO）-mediated c-Met siRNA and to observe its antihepatocarcinoma effect. Methods Gal-PEI-SPIO nanocarriers were prepared and characterized. Agarose gel electrophoresis was used to detect the combination of carriers and siRNA. The cytotoxicity of the nanocarriers was determined by CCK-8. At the same time， q-PCR and Western blotting were used to detect the silencing efficiency of carriers carrying c-Met siRNA in cells. The effects of Gal-PEI-SPIO/c-Met siRNA nanocomposites on the migration and invasion of liver cancer MHCC-97H cells were detected by Transwell chamber method. Result Agarose gel electrophoresis showed that Gal-PEI-SPIO nanocarriers and siRNA could be closely combined when the SPIO： siRNA mass ratio was 4：1 or more. Simultaneously, when the ratio was more than 4：1，the cell activity decreased rapidly. The qPCR results showed that Gal-PEI-SPIO/siRNA nanocomposites effectively reduced the level of mRNA in MHCC-97H cells, and Western blotting showed that the Gal-PEI-SPIO/c-Met siRNA nanocomposites effectively reduced c-Met mRNA and protein levels （all P<0. 01）. In cell invasion and migration experiments, GalPEI-SPIO/c-Met siRNA nanocomposites significantly reduced the invasion and migration abilities of MHCC-97H cells. Conclusion Gal-PEI-SPIO nanocarriers can bind tightly to siRNA, and can carry c-Met siRNA into hepatocellular carcinoma cells to silence c-Met, thereby inhibiting the invasion and migration of MHCC-97H cells. [ABSTRACT FROM AUTHOR]

Objective To screen out th e gastric cancer-related differentially expressed genes ( DEGs), to analyze the biological function and signal pathways, and to explore the relationship between the expression of gastric cancer related core DEGs and the prognosis of gastric cancer. Methods Microarray data of gastric cancer GSE79973 and GSE54129 were downloaded from Gene Expression Omnibus database ( GEO) . We used GE02R to pick out DEGs between gastric cancer and normal gastric tissues. Then we obtained the common DEGs. We used DA YID to analyze the biological functions and signal pathways of DEGs. The protein-protein interaction ( PPI) of these DEGs was constructed by STRING, then we imported it into Cytoscape. The core genes related to gastric cancer were screened out by MCODE plug-in. Finally, we analyzed the overall survival among those core genes. Results There were 164 DEGs in the two datasets, including 42 upregulated genes and 122 down-regulated genes. These DEGs mainly enriched in extracellular region, proteinaceous extracellular matrix, extracellular matrix, and extracellular exosome. They involved in ECM-receptor interaction, focal adhesion, protein digestion and absorption, cytochrome P450 metabolism and other related pathways. Preliminarily, we screened out 13 core genes ( COL1 A2, BGN, THBS2, FNl, THBSl, COLl Al, COIAAl, SPARC, COLl l Al, COL6A3, COL12Al, TIMPl, and SPPl ) related to gastric cancer by MCODE, and 12 of 13 genes had a significantly worse prognosis. Except THBSl, the remaining 12 core genes were significantly associated with poor prognosis of gastric cancer ( all P < 0. 05 ). Conclusions A total of 164 gastric cancer-related DEGs are screened out, including 42 up-regulated genes and 122 down-regulated genes. They are mainly located in extracellular region and proteinaceous extracellular matrix, which are related to ECM-receptor interaction, focal adhesion, and other related pathways, and 12 of 13 gastric cancer-related genes, such as COLI A2, BGN, and THBS2 are associated with poor prognosis of gastric cancer [ABSTRACT FROM AUTHOR]

As a unique part of Chinese herbal medicine? charred Chinese medicinal herbs? or charred herbs for short，enjoyed a long history and abundant clinical applications. Charred herbs were firstly used by accident，and later more were used intentionally and systematically until finally a theory was formed， the whole process of which took a long time. As early as in the Qin and Han dynasties, the mystery of using charred herbs to cure diseases was unveiled in medical practice. The types and processing methods of charred herbs increased and improved over the later dynasties. It was widely used in internal medicine，external medicine，gynecology，and pediatrics，etc. Its curative effects were proven in clinical practice in the past and has been confirmed by more and more pharmacological researches now. Through a thorough review of ancient literature，it ' s believed that the application of charred herbs was one of the pioneering medical practices of our ancestors and its vitality lies in its great efficacy. This paper provides literature basis and ideas for more profound research into charred herbs, on which further studies are warranted. [ABSTRACT FROM AUTHOR]

《临床生物化学检验》是该校医学检验专业的一门重要主干课,也是由多种学科和多种技术融合而成的一门应用 型学科。不断涌现的检验医学新技术对大专院校培养医学检验专业学生提出了新的要求,更对传统《临床生物化学检验》的教学 内容和教学形式提出了严峻的挑战。为提高课程的学习效果,作者尝试在绪论教学阶段进行了改革,以期为培养能够适应新形势 的检验人才提供参考。 [ABSTRACT FROM AUTHOR]

Objective To explore the kinase activity of novel receptor interacting protein kinase 3 (RIPK3) mutants. Methods 瞬 The four amino acids (Q84WDF87) of RIPK3 were mutated respectively and these mutants were co-transfected with mixed lineage kinase domain like pseudokiiiase (MLKL) into HEK293T cells. The auto-phosphoiylation of these mutants at S232 and phosphorylation of MLKL at S345 were detected by Western blotting. The interaction between RIPK3 and MLKL was tested by co-immimoprecipitatiotL The oligomerization of MLKL was detected by non-reducing gel. Results The kinase activities of REPK3AQ84, RIPK3AW85 and RIPK3AD86 were effectively decreased. Nevertheless, the kinase activities of RIPK3Q84A/RIPK3Q84E, RIPK3W85Y and RIPK3D86A/RIPK3D86Y did not change markedly. The auto-phosphorylatioii of RIPK3W85A at S232 was decreased without affecting phosphorylatioii and oligomerization of MLKL. Conclusion • The amino acid site Q84, W85 or D86 plays a critical role in RIPK3 kinase activity. The kinase activity ofRIPK3W85Ais decreased, but it does not affect MLKL. [ABSTRACT FROM AUTHOR]

Objective: To investigate the expression of human epidermai growth factor recepetor-2(C-erbB-2) and thyroid transcription factor-1(TTF-1) in endometrial carcinoma and its relationship of prognosis. Methods: To examine the expression of normal endometrium, atypical hyperplasia and endometrial carcinoma by immunohistochemistry, and to discuss both relation to clinical pathological feature and prognosis of endometrial carcinoma. Results: The expression rates of C-erbB-2 in endometrial carcinoma,atypical hyperplasia and normal endometrium were 56.65%, 36.67%, 16.67%(P<0.05), and the expression rates of TTF-1 were 33.75%,53.33%, 70.00%(P<0.05). The positive expression of C-erbB-2 was associated with pathological stage, histological grade, myometrial infiltration and lymphatic metastasis(P<0.05), while not with pathological type(P>0.05). The negative expression of TTF-1 was correlated with pathological stage, histological grade, myometrial infiltration(P<0.05), while not with lymphatic metastasis and pathological type(P>0.05). The expression of C-erbB-2 and TTF-1 in endometrial carcinoma was not associated(P=0.303). The 5-year survival rate was lower in C-erbB-2 positive group than that in negative group(P<0.05). But there was on difference of 5-year survival rate between TTF-1 positive and negative group(P>0.05). Conclusion: The expression of C-erbB-2 of endometrial carcinoma tissues was up-regulatied, while the expression of TTF-1 was down-regulated. Both C-erbB-2 and TTF-1 were involved in the occurrence and development of endometrial carcinoma. The up-regulation of C-erbB-2 was associated with the poor prognosis of endometrial carcinoma. [ABSTRACT FROM AUTHOR]

Objective: To investigate the correlation of serum γ-glutamyl transferase(GGT) level with the influencing factors of coronary heart disease and the severity of patients with vascular disease. Methods: 61 patients diagnosed as coronary heart disease(CHD)from July 2013 to October 2017 in our hospital through coronary angiography were selected as the experimental group, which were divided into stable angina pectoris group(hereinafter referred to as A group, 20 cases), unstable angina(group B, 21 cases) and acute myocardial infarction(group C, 20 cases) according to their clinical symptoms. In the same period, thirty patients without coronary heart disease were selected as the control group. The levels of fasting blood glucose(FBG), total cholesterol(TC), triglyceride(TG), systolic blood pressure(SBP), diastolic blood pressure(DBP) and uric acid in the four groups were measured and compared. The correlation of coronary Gensini score. Finally, the GGT and Gensini scores of four groups of patients were analyzed. Results:(1) The FBG, serum TC,TG, SBP, DBP and uric acid levels in the four groups were significantly different(Group C>Group B>Group A>Control group, P<0.05);(2)The level of GGT was positively correlated with the above risk factors(r=0.236, 0.351, 0.316, 0.239, 0.301, 0.395, P=0.035, 0.000,0.000, 0.0034, 0.001, 0.000);(3)Both GGT and Gensini scores in the four groups were changed according to the trend of Group C>Group B>Group A>Control group(P<0.05);(4) The serum GGT level of patients with coronary heart disease was positively correlated with Gensini score(r=0.681, P=0.000). Conclusion: The serum GGT levels of CHD patients were positively correlated with the serum levels of FBG, TC, TG, SBP, DBP, uric acid levels and the severity of the vascular lesions, it may be used to predict the severity of lesion in CHD patients. [ABSTRACT FROM AUTHOR]

Objective To construct a prognostic prediction model for chronic postsurgical pain after video-assisted thoracoscopic surgery and develop a risk evaluation tool. Methods As a single-center prospective study, the study enrolled 1 132 patients received video-assisted thoracoscopic surgery between November 2020 and May 2021 at Peking Union Medical College Hospital. Numeric rating scale was used to assess the severity of acute pain when they were discharged and chronic pain at 6 months after surgery. Patients were divided into two groups based on the presence or absence of chronic postsurgical pain. Multivariate Logistic regression was conducted to analyze the risk factors which were used to construct prediction model and draw nomogram for chronic postsurgical pain after video-assisted thoracoscopic surgery. Results 460 patients (40.6%) were reported chronic pain at 6 months after surgery. More women and more patients with coronary heart disease belonged to the group of chronic postsurgical pain. Patients reported higher scores of numeric rating scale when they were discharged and inclined to keep taking painkiller after discharge. However, there were fewer patients with incisions fewer than 3 or using nitrous oxide during surgery in the group of chronic postsurgical pain (P＜0.05). The outcome of multivariate Logistic regression showed that the history of coronary heart disease, not using nitrous oxide in surgery, incisions more than or equal to 3, and the score of numeric rating scale on discharge were independent risk factors for chronic postsurgical pain (P＜0.05). The area under the receiver operator characteristic curve of the prediction model was 0.734. Conclusions The prediction model is conducive to clinical management for chronic postsurgical pain after video-assisted thoracoscopic surgery. [ABSTRACT FROM AUTHOR]

The minimal correction subset (MCS) of a Boolean formula is a set of clauses. By removing the MCS from a given unsatisfiable formula, the new generated formula becomes satisfiable. For any clause in the MCS, keeping the clause in the given unsatisfiable formula results in a new unsatisfiable formula. Minimal unsatisfiable core, MaxSAT and maximal (minimal) partial assignment can be solved by solving the MCS and adjusting the set of constraints. The MCS can also be applied to practical problems such as fault localization, model checking and configuration optimization. We propose an MCS calculation algorithm based on unsatisfiable reasons returned from SAT solvers, and implement a corresponding tool named CUC. Comparing with the state-of-theart tool LBX, the CUC outperforms LBX. The CUC can solve 5% (65) more formulas on average, and it is 2.5 times faster than LBX. [ABSTRACT FROM AUTHOR]

[Objectives] This study aims to investigate the role of oligosaccharide repeat unit polymerase Wzy on the pathogenicity of Streptococcus suis serotype Chz. [Methods] The genetic diversity of S.suis capsular polysaccharides(CPS)gene cluster was explored by ACT comparative genomics method. The gene wzy and cpsB mutant strains were then constructed respectively, and the CPS thickness was identified by TEM. The cell and animal experiments were applied to verifing the effects of Wzy on bacterial pathogenicity. [Results] The mutant strain exhibited the reduced capsular-like substance and a stronger biofilm-forming ability compared with the wild-type strain. Cell experiments showed that the mutant strain had stronger adhesion to mouse brain microvascular endothelial cells(bEnd.3), while was more sensitive to the phagocytosis of mouse macrophages RAW264.7. In addition, the deletion of gene wzy significantly attenuated the bacterial pathogenicity and proliferation in vivo. [Conclusions] Polymerase Wzy affects the pathogenicity of Streptococcus suis. [ABSTRACT FROM AUTHOR]

The Ag2S/TNTs hydrogen evolution electrode was prepared by chemical bath deposition of Ag2S on highly ordered TiO2 nanotubes (TNTs) using sodium sulfide and silver nitrate as starting materials. Scanning electron microscopy (SEM), X-ray diffraction (XRD) and X-ray photoelectron spectroscopy (XPS) were used to characterize the electrodes. The results showed that Ag2S particles were uniformly deposited on the surface of TiO2 nanotubes without destroying the original morphology and structure of the nanotubes. The hydrogen evolution performance of the composite electrode with different deposition cycles of Ag'S was analyzed by linear sweep voltammetry (LSV), Tafel curve, double layer capacitance analysis and electrochemical impedance spectroscopy (ETS) at room temperature of 0.5 mol/L H2SOq. Compared with TNTs, Ag2S/TNTs showed better hydrogen evolution performance. When the number of Ag2S deposition cycles is 9, the overpotential of the prepared composite electrode reaches 288. 14 mV at the current density of 10 mA/cm², the Tafel slope is 61.8 mV/dec, the double layer capacitance is 54.7 mF/cm², and the internal resistance of charge transfer is reduced to 0.7 Q/cm². [ABSTRACT FROM AUTHOR]

霍奇金淋巴瘤 (Hodgkin lymphoma, HL )、间变性大细胞淋巴瘤 (anaplastic large cell lymphoma, ALCL)及其他淋 巴瘤中均有不同程度的CD30表达。维布妥昔单抗 (Brentuximab vedotin, BV)作为一种针对CD30的抗体⁃药物偶联物, 使淋巴瘤治疗的取得重要进展。BV目前已被批准用于治疗复发性HL和ALCL, 以及HL的移植后维持治疗, 并且已被 证明对其他表达CD30的淋巴瘤有效。本文就BV在HL、ALCL和其他淋巴瘤中的研究进展进行综述。 [ABSTRACT FROM AUTHOR]

Objective To investigate the relationship between 1q21 amplification (1q21+) and the treatment efficacy and prognosis of the newly diagnosed multiple myeloma (NDMM) patients, and to explore the advantage of 1q21+ in the risk stratification of MM. Methods The patients with NDMM treated in Beijing Lu⁃He Hospital, Capital Medical University, from November 2015 to November 2021 were selected as the research objects. The cytogenetic abnormalities were detected by the interphase fluorescence in situ hybridization (iFISH). The relationship between 1q21+ and the efficacy and prognosis of bortezomib based induction chemotherapy and autologous stem cell transplant (ASCT) were analyzed. The stratification advantages of MM R2⁃ISS and R⁃ISS were compared. Results A total of 159 NDMM patients were included in this study, 79 patients with 1q21+ and 80 patients with no 1q21+, of whom 41 patients were treated with RVD regimens and 118 patients with no⁃RVD regimens. Among 1q21+ patients, the complete remission (CR) rate of the RVD group was higher than that of the no⁃RVD group (P<0.001). In RVD group, the CR rate of 1q21+ patients was lower than that of no 1q21+ patients (P=0.004). Multivariable analysis showed that 1q21+ was an independent risk factor for the progression⁃free survival (PFS) and the overall survival (OS) in the patients with NDMM (P<0.05). Among the 50 patients receiving ASCT, the 1⁃year and 3⁃year OS and PFS rates of 1q21+ patients were shorter than those of no 1q21+ patients (P=0.055, 0.002). The 1⁃year PFS rates of patients with stageⅠ, Ⅱ,Ⅲ and Ⅳ of R2⁃ ISS were 96.3%, 95.0%, 92.0% and 85.4%, respectively, and the 3⁃ year PFS rates were 88.9%, 80.5%, 74.0% and 61.5%, respectively, with statistical significance (P=0.005). Conclusions 1q21+ is an independent risk factor for the OS and PFS in the patients with NDMM, which is associated with poor prognosis. RVD can improve the remission depth of 1q21+ NDMM patients, while ASCT can improve the prognosis of patients, but neither of them can completely overcome the adverse effects of 1q21+. Clinically, the R2⁃ISS has advantages in the MM risk stratification. [ABSTRACT FROM AUTHOR]

Objective To investigate the effect of sub-acute exposure to benzene on hematopoietic system in rats and to explore its related mechanism. Methods Thirh male SD rats were raixlomly divided into the blank control group, solvent control group, low-dose benzene group, medium-dose benzene group and high-dose benzene group, with 6 rats in each group. Benzene exposure groups were given 200, 400 and 800 mg/kg benzene solution respectively according to the body mass, the blank control group was not treated, and the solvent control group was given equal volume of corn oil, once a day and for 28 days. Routine blood test was analyzed by automatic blood-counter system. We killed the rats, then calculated the coefficient of liver and spleen, and observed the pathological changes of the femur and the morphological changes of bone marrow and peripheral blood cells. DNA damage of bone marrow and peripheral blood cells were detected by single cell gel electrophoresis (SCGE), and we recorded the tail moment (TM) and Olive tail moment (OTM). Results The WBC of low-dose, medium-dose and high-dose benzene groups were lower than that of the blank control group and the solvent control group (P <0.05). The RBC-in the high-dose benzene group was lower than the other groups, and ihe hemoglobin (Hb) in the medium-dose and high-dose benzene groups was lower than that of the other groups (P < 0.05). There was no significant difference in PLT among these groups (all P > 0.05). There were no significant differences in liver and spleen coefficients among these groups (all P >0.05). In the blank control group and solvent control group, the morphological changes of the bone marrow and peripheral blood cells and the palhologie changes of the bone marrow were basically consistent. The pathological changes showed that in the three benzene groups, the area of hematopoietic tissue was decreased, there were more toxic particles and vacuoles in the bone marrow and peripheral blood cells, meanwhile, with the increased dose of benzene, the above changes were more significant. Compared with the blank control group and solvent control group, TM and OTM were increased in turn in the three benzene groups (P<0. 01). Conclusion Aub-acute ex­posure to benzene has a toxic effect on bone marrow of rats with a dose-dependent manner, which may be rated to DNA damage in peripheral blood and bone marrow cells. [ABSTRACT FROM AUTHOR]

Ovarian cancer is a common gynecological malignancy and one of leading causes of cancer-related morbidity and mortality in female patients around the globe. The metastasis of ovarian cancer is an important factor in causing deaths. EMT (epithelial-mesenchymal transition) refers to the transition process from the phenotype of epithelial cells to mesenchymal phenotype and is closely associated with the malignant progression of tumors in its invasion and metastasis. MicroRNA (miRNA) are a class of small molecule and noncoding RNAs which inhibit translation of the mRNA transcript of the genes expression, and become more and more concerned in regulating EMT progress. Many kinds of miRNA expressed abnormally and related to the occurrence and development of ovarian cancer, are expected to be used in early diagnosis, treatment and prognosis. In this review, we presented recent research regarding the role of EMT and related microRNAs in the malignant progression of ovarian cancer. [ABSTRACT FROM AUTHOR]

Runoff and sediment characteristics can be the important indicators on the soil erosion. However, it is still unclear on the runoff and sediment variations of the watershed in the red soil region of southern China, especially after a continuous soil erosion control. This study aims to investigate the characteristics of runoff and sediment in the small watershed after the long-term soil and water conservation in the red soil region of southern China. The Zhuxi watershed in Changting County Fujian Provence was taken as the study area to collect the rainfall and hydrological data from 2017 to 2020. A systematic analysis was implemented to determine the runoff and sediment relationships of the flood events using redundancy analysis (RDA), multiple stepwise regression equations, and sediment concentration (C)-discharge (Q) hysteresis loop methods. The results showed that: 1) The monthly average runoff and sediment concentration were consistent with the trend of monthly rainfall changes during the study period. The annual flood runoff depth and sediment yield were 282.30-892.50 mm and 35.80-179.50 t/km², respectively. The sediment modulus of the flood events was distributed mainly in 0-20.0 t/km². But the total flood sediment yield were determined by a few flood events with the sediment modulus greater than 5.0 t/km². 2) Rainfall (P), the maximum rainfall intensity of 30 min (I30), and rainfall erosivity (R) were the main rainfall characteristics that affected the runoff and sediment. However, the contribution rates of rainfall characteristics to the variations of runoff and sediment were 68.99% and 49.28%, respectively. It infers that the rainfall characteristics were more closely related to the runoff indicators than to the sediment indicators. The runoff was the most important influencing factor of sediment. Thus, the great fitting was achieved in the R² range of 0.624-0.870 with estimating the sediment yield (S), average sediment concentration (Cm), and the maximum sediment concentration (Cmax) of flood events using main runoff indicators, including the runoff depth (H), average discharge (Qm), and peak flow (Qmax). 3) There were six types of C-Q hysteresis loops in the flood events with the sediment modulus greater than 0.1 t/km². Among them, the occurrence frequencies of the single-valued and complex loop were 55% and 22%, respectively. The counterclockwise loop was more appeared in the flood events with the small sediment modulus. The highest occurrence frequency was found in the single-valued loop. The variation of C with Q in the single-valued flood events was characterized by the phased method. The critical C value was about 0.1 g/L, as the C-Q relationship changed. The sediment carrying capacity of runoff was significantly changed at a sediment concentration of about 0.1 g/L. Moreover, the single-valued loops were also dominated in the C-Q hysteresis loop for the large-scale flood event in the watershed. There were the low sediment yields of the flood events and the great influence of the runoff on the flood sediment in the watershed of the red soil region after a long-term soil erosion control. The sediment supply of the flood events, including the large-scale flood events, in the watershed was generally in a continuous and limited state. The findings can provide the much more comprehensive understanding of the runoff and sediment processes in the watershed with continuous soil and water conservation, in order to reveal the development of soil erosion in the red soil region of southern China. [ABSTRACT FROM AUTHOR]

Objective To explore the risk factors of adverse discharge outcomes in patients with acute ischemic stroke (AIS), and the effects of post-stroke infection on discharge outcomes. Methods AIS patients who were hospitalized in the Department of Neurology, Beijing Tiantan Hospital, Capital Medical University from June 2019 to June 2022 were retrospectively included in this study. The patients were divided into good outcome group (mRS score<3) and poor outcome group (mRS score >3 or death during hospitalization) according to discharge outcome. The clinical characteristics and post-stroke infection(pulmonary infection, urinary tract infection and central nervous system infection) were compared between the two groups. Multivariate logistic regression was used to analyze the risk factors for adverse discharge outcomes in AIS patients. Results A total of 1024 patients with AIS were included in this study, with a mean age of (60.3±12.4) years old and 788 males (77.0%). There were 761 (74.3%) patients in the good outcome group and 263(25.7%) patients in the poor outcome group. 85 (8.3%) patients developed infection after stroke, of which 69 (6.7%) were pulmonary infections, 16 (1.6%) were urinary tract infections, and 3 (0.3%) were central nervous system infections. Multivariate analysis showed that pulmonary infection (OR 2.522, 95%CI 1.318-4.828, P=0.005), diabetes (OR 1.486, 95%CI 1.048-2.106, P=0.026), increased NIHSS score on admission (OR 1.286, 95%CI 1.233-1.342, P<0.001) and increased white blood cell count (OR 1.094, 95%CI 1.014-1.180, P=0.020) were risk factors for poor discharge outcomes in AIS patients. Conclusions Pulmonary infection may significantly increase the risk of poor discharge outcomes in patients with AIS. [ABSTRACT FROM AUTHOR]

Objective To evaluate the predictive value of Cr-POSSUM scoring systems in patients with rectal cancer after surgery. Methods 276 patients who underwent surgery with colorectal malignant neoplasms were divided into two groups depending on Cr-POSSUM total scores. Scores 17 points or less were defined as low-risk patients, scores more than 18 points were defined as a high-risk patients. The predicted results were compared with the actual situation by receiver-operating characteristic curve （ROC curve） and the ratio of expected mortality and obseved mortality to evaluate the accuracy. Results In the comparison of patients with high-risk group and low risk group， age， PS score， OS scores， postoperative bleeding and mortality in 30 day after surgery had a statistically significant difference（p P＜0.05） . Conclusion Cr - POSSUM can accurately predict the postoperative mortality of patients with rectal cancer. [ABSTRACT FROM AUTHOR]

Objective To produce silk fibroin/chitosan scaffolds (SFCSs) by freeze drying method so as to provide the theoretical foundation for subsequent experiments which aim to select appropriate scaffolds. Methods Silk was degummed, dissolved and purified to obtain appropriate concentration of silk fibroin solution, which was then mixed with chitosan solution by the ratio of 4∶6. The SFCSs were prepared by freeze drying method. The scaffolds' properties including pore diameter, porosity, fracture strength, water swelling rate, and degradation rate in vivo and in vitro were tested; the biodegradability was observed from the morphological perspective by HE staining and micro-CT. Results SFCSs' pore diameter was 100～120μm, fracture strength was (8.31±1.271)MPa, porosity was (84.32±5.14)%, water swelling rate was (137±7.15)%, and the degradation rate in vivo and in vitro did not differ at week 2 (P>0.05), but differed significantly at week 6 and week 10 (P<0.05). HE staining and micro-CT further proved its good biodegradability in vivo from the morphological perspective. Conclusion We made successful production of SFCS scaffolds, of which pore diameter, fracture strength, porosity, water swelling rate, and degradation rate in vivo and in vitro fully meet the requirement of spinal cord tissue engineering. It will provide a solid foundation for subsequent experiments that use tissue engineering technology to repair spinal cord injury. [ABSTRACT FROM AUTHOR]

Objective: To explore the influence of simvastatin plus low molecular heparin on D-dimer, N-terminal brain natriuretic peptide precursor (NT-pro BNP), left ventricular ejection fraction (LVEF), left ventricular end-diastolic diameter, serum c-reactive protein (CRP), plasma fibrinogen (FB), serum total cholesterol (TC), low density lipoprotein cholesterol (LDL-C) in patients with chronic heart failure (CHF). Methods: A total of 80 patients with CHF, who were treated in Dalian Center Hospital from April 2010 to July 2014,were selected and randomly divided into treatment group (n=40) and control group (n=40). The two groups were all treated with conventional therapy, based on which, the treatment group was added simvastatin plus low molecular heparin, the course of treatment was two months.The levels of D-dimer, NT-pro BNP, LVEF, left ventricular end-diastolic diameter, CRP, FB, TC and LDL-C in the two groups before and after treatment were compared. Results: Compared with before treatment, the levels of D-dimer, NT-pro BNP, LVEF, left ventricular end-diastolic diameter, CRP, FB, TC and LDL-C in the control group after treatment were not obviously improved, while the above indexes in the treatment group were improved significantly, the differences were statistically significant (P<0.05). Conclusion: Simvastatin plus low molecular heparin can effectively improve the relevant indexe of patients with CHF, which plays an important role in the clinical treatment and is worthy of clinical application. [ABSTRACT FROM AUTHOR]

Objective: To analyze the effect of combined orthognathic and orthognathic treatment of skeletal class III malocclusion on the changes of soft and hard tissue in the profile of patients detected by cone beam computed tomography (CBCT). Methods: From December 2017 to December 2020, 50 patients with skeletal class III malocclusion admitted to the Stomatological Hospital of Fourth Military Medical University (The Third Affiliated Hospital of Air Force Military Medical University) were selected as the research objects. All patients received orthodontic treatment. Jaw combined treatment, followed up for 6 months after treatment. The angle and thickness of the soft and hard tissue, the distance from the soft and hard tissue markers to the vertical reference line, and the reduction in root volume and root length of the upper and lower central incisors were compared before treatment and after 6 months of follow-up and the reduction percentage, the volume reduction and reduction percentage of the root neck and root body of the upper and lower central incisors. Results: After 6 months of follow-up, the vertical reference line of upper lip (UL-VRL), nasolabial angle (NLA), sagittal distance of upper central incisor (DUI), upper lip The point sagittal plane distance (DUL') was increased compared with that before treatment, MLA, subnasal point anterior inferior angle (MP-SN), L1-SN, lower lip point vertical reference line (LL-VRL), Pog-VRL, The sagittal plane distance of the geniolabial fold point (DBs), the sagittal plane distance of the anterior point of the genital point (DPo), the sagittal plane distance of the anterior point of the soft tissue (DPos), the sagittal plane distance of the lower central incisor point (DLI), the lower lip The sagittal plane distance from the border point (DLL'), the vertical distance from the front of the chin to the nasion point and the alveolar seat point (Po-NB) were lower than those before treatment (P<0.05). After 6 months of follow-up, the total root volume and root top volume of the upper central incisors were higher than those of the lower central incisors (P<0.05); the volume change and volume reduction percentage of the upper central incisors and lower central incisors at the root neck were lower than those of the lower central incisors. Root body (P<0.05). Conclusion: Combined orthodontic and orthognathic treatment can improve the profile soft and hard tissue of patients with skeletal class Ⅲ malocclusion, but it can lead to root resorption. [ABSTRACT FROM AUTHOR]

This study aimed to clarify the spatial differentiation of soil geotechnical characteristics in Benggang area and reveal the quantitative relationship betweensoilphysicochemical properties and shear strength. The differences of soil physicochemical properties and shear strength at different depths vertically (red soil, sandy soil and detritus layers) and horizontally (surface and inner soils) were analyzed in a typical Benggang area of Anxi County, Fujian Province, China. The contents of free and amorphous iron and aluminum oxides in surface soil exceeded those in the inner soil for the three soil layers. There were no obvious differences in organic matter, pH value, particle composition, and shear strength parameters between the surface and the inner soils. Significant differences were found in soil properties among the different soil layers of gully wall. The contents of free and amorphous iron and aluminum oxides, and clay particles of the red soil layer were the greatest, and the cohesion of red soil layer was the largest. The smallest values were obtained for the detritus layer. Correlation analysis revealed significant positive correlation between free and amorphous iron and aluminum oxides, organic matter, medium silt and smaller fine particles, and soil cohesion. Significant negative correlation was found between free manganese oxide, coarse silt and larger coarse particles, and soil cohesion. The internal friction angle positively correlated with free iron oxide. Stepwise regression analysis showed that amorphous aluminum, free iron oxide, fine clay particles, and fine silt particles were the main soil factors affecting the soil shear strength of the gully wall (r=0.96, P<0.01, RMSE=10.44). [ABSTRACT FROM AUTHOR]

[Objectives]The purpose of this study was to predict and identify the integrative and conjugative elements(ICE)in the clinical isolates of Streptococcus suis serotype Chz AH681 and HN136,to detect the cyclization activity of the them, and to explore the relationship between the ICE and drug-resistant gene transfer and the mechanism of multiple drug resistance. [Methods]The minimum inhibitory concentration method was used to determine the drug resistance in the two strains of clinical isolates of S. suis serotype Chz. ICE in these strains were predicted using bioinformatics methods, and localized consulting the location characteristics of reported S. suis ICE. The cyclization and conjugating tests were performed to detect the activity of predicted ICE. The relationship of ICE in S. suis was analyzed by constructing evolutionary tree. [Results]Both AH681 and HN136 were multi-drug resistant strains. They all had obviously exogenous islands. Among them,73 kb and 115 kb gene islands possessed typical characteristics of integrated conjugative elements and the 73 kb(ICESsuAH681)and 115 kb(ICESsuHN136)gene islands belong to the ICESa2603 family. Further analysis revealed that the ICESsuAH681 contained tetracycline resistance gene tet(O), the macrolide antibiotic resistance gene erm(B), the fluoroquinolone export ATP-binding protein gene, the bacteriocin operon gene and the arsenate reductase gene; ICESsuHN136 contained tet(O), erm(B)and the bacteriocin gene cluster. The cyclization test confirmed that the ICESsuAH681 could be cut off from the genome and formed rings autonomously, but the conjugon in P1/7 strain containing ICESsuAH681 was not obtained. No circular form of ICESsuHN136 was detected. The evolutionary relationship analysis showed that the well-bounded ICE in S. suis had six major branches, among which ICESsuAH681 was more closely related to ICE in the ICESa2603 family. [Conclusions]This study confirmed that ICESsuAH681,which came from a multidrug-resistant strain of S. suis serotype Chz and carried resistance genes such as tet(O), erm(B)and arsc, could be removed from the genome and cycled. It was an active ICE and a member of the ICESa2603 family. [ABSTRACT FROM AUTHOR]

Objective: To investigate the changes of perioperative liver coagulation function in the elderly intertrochanteric fracture patients with chronic schistosorniasis. Methods: A retrospective review of 260 elderly intertrochanteric fracture patients with chronic schistosorniasis treated by PFNA between September 2015 and June 2018 (115 cases with chronic schistosorniasis). We analyzed and compared the changes of lver and coagulation function during perioperative period Results: Compared with the normal group, there were obvious abnormalities in preoperative liver function and coagulation function in patients with chronic schistosorniasis group, such as ABD, TBIL, ALT, PT, FIB. Liver and coagulation function improved obviously through preoperative drug therapy and perioperative drug maintenance. Conclusions: In elderly intertrochanteric fracture patients combined with chronic schistosomiasis, liver function and coagulation function are obvious abnormalities doing perioperative period. It is very important to adjust the liver and coagulation function in these patients positively. Meanwhile, we should pay more attention to use the postoperative anticoagulant drugs in these patients. [ABSTRACT FROM AUTHOR]

A simple and portable wave optical measurement instrument was dsigned. Bv using the instrument, one can illustrate each red and green laser double-slit experiment, single slit diffraction and circular aperture diffraction, grating diffraction, polarization experiment. In order to compare the difference of red and green waves, one can also demonstrate both red and green laser’s above phenomenon by the instrument. And the instrument can easily measure the wavelength of light and the diameter of airy disk and the grating constant and so on. The instrument is small, easy operation, suitable for classroom demonstration teaching and experiment instrument for students. [ABSTRACT FROM AUTHOR]

目的 比较子宫浆液性乳头状癌(UPSC)与子宫内膜样腺癌(EAC)的MRI检查结果. 方法 回顾性分析经手术病理证实的22例UPSC的MRI资料. 随机选择同期收治、资料完整且经手术病理证实的43例EAC的MRI资料作为对照. 分析二者的MRI征象. 结果 UPSC、EAC中肿块型病灶分别为15(68.18%)、8(18.60%)例,二者比较,P<0.05. UPSC和EAC在T2 WI上病灶信号强度比较无统计学差异;在T1 WI上4例UPSC病灶内可见斑点状高信号. 22例UPSC中有14例(63.64%)宫腔内病灶最大径与最大肌层浸润深度的比值≤1,12例纯型UPSC中10例(83.33%)其比值≤1,43例EAC中5例(11.63%)其比值≤1,三者比较,P均<0.05. 20例UPSC病灶周围存在正常子宫内膜(90.91%),12例纯型UPSC病灶周围均可见正常厚度子宫内膜,10例(23.26%)EAC病灶周围存在正常子宫内膜,UPSC与EAC病灶周围存在正常子宫内膜率比较,P<0.05. T1 WI增强扫描中18 例(81.82%)UPSC为明显强化—上升型方式,明显高于EAC(25.58%),P<0.05. 5例纯型UPSC伴发卵巢肿块,共8个卵巢肿块的体积(≥50 mm)均大于其子宫病灶,8个卵巢肿块中6个为巨大囊实性肿块. 纯型UPSC中卵巢肿块的出现率(41.67%)明显高于EAC(6.98%),P<0.05. 结论 UPSC与EAC的MRI表现不同,UPSC以肿块型病灶多见,病灶大小与肌层浸润深度不成比例,非病灶区多可见菲薄内膜,血供较EAC丰富,增强扫描较EAC强化明显,卵巢出现体积大于子宫病灶的巨大肿块,囊实性多见. [ABSTRACT FROM AUTHOR]

Objective: To investigate the expressions of WT-1 and Smac protein in epithelial ovarian cancer and their clinical significances. Methods: Immunohistochemistry was used to detect the expressions of WT-1 and Smac protein in 40 cases of normal ovarian tissues, 40 cases of epithelial ovarian benign tumor tissues and 60 cases of epithelial ovarian cancer tissues, the correlations of WT-1 expression with Smac expression and clinicopathological features of epithelial ovarian cancer were analyzed. Results: The expression of WT-1 protein in epithelial ovarian cancer tissues was significantly higher than that in the normal ovarian tissues or ovarian epithelial benign tumor tissues(P0.05).The expression of Smac protein in epithelial ovarian cancer tissues was significantly lower than that in the normal ovarian tissues or ovaries epithelial benign tumor tissues(P 0.05). The expression of WT-1 and Smac protein in epithelial ovarian cancer was significantly correlated with the clinical stage, histological differentiation and lymph node metastasis(P0.05). The expressions of WT-1 and Smac protein in epithelial ovarian cancer were negatively correlated(r=-0.35, P0.05). Conciusions:High expression of WT-1 protein or low expression of Smac protein may play important roles in the occurrence and development of epithelial ovarian cancer, detection of WT-1 and Smac protein expressions may contribute to the prognostic prediction of epithelial ovarian cancer. [ABSTRACT FROM AUTHOR]

Objective To analyze the risk factor of postoperative urinary retention（POUR） in patients with colorectal malignant neoplasms. Method 527 patients，hospitalized fromOctober， 2013 to September， 2015 in the Second Affiliated Hospital of Kunming Medical University and diagnosed with colorectal malignant neoplasms， were divided into two groups depending on whether postoperative urinary retention occurs. Gender， age， preoperative complications，body mass index，preoperative hemoglobin，preoperative albumin，intraoperative circumstances，time for indwelling catheter after operation and length of stay were analyzed and compared between two groups. Results Compared with the group without postoperative urinary retention，the group with postoperative urinary retention was different in gender， urinary complications， body mass index≥30 kg/m2， with rectal malignant neoplasm， with low Anterior Resection or abdominoperineal Resection， with T4 stage and with operation time≥240 min，wich has have statistical significance（ P＜0.05）.Conclusion The male who have urinary system disease and whose body mass index is more than 30 kg/m2 are in high risk of postoperative urinary retention. Meanwhile rectal malignant neoplasm，with low Anterior Resection or abdominoperineal Resection，T4 stage tumor and operation time≥240 min are the high risk factors.Once postoperative urinary retention occured，the length of stay and the risk of urinary tract infections would increase. [ABSTRACT FROM AUTHOR]

Objective: To analyze the effect of single disease quality management in a third-grade class-A hospital. Methods: To summarized the implementation of the single disease quality management in Shaanxi People’s Hospital, and retrospectively analyzed the changes of hospital outpatients, the hospitalization and costs. Results: Through the implementation of single disease quality management,the physician practice behavior is standardized and the medical service quality is improved, the average hospitalization day is shortened,the medical cost and the economic burden of patients is reduced. However, the medical staffs were less of awareness on the single disease quality management, single disease diagnostic criteria are not standardized, and the price of a single disease has a potential impact on medical quality. Conclusion: We should improve the level of single disease quality management by constantly summarizing the experience, in order to prompt sustained and healthy development of medical market in China. [ABSTRACT FROM AUTHOR]

Objective To compare the levels of vitamin D and bone mineral density between the underground and upground workers in the coal mine,for exploring the effect of the different working environment on the occurrence of osteoporosis. Methods Using prospective control method,a total of 120 workers in Kailuan Tangshan mine were selected,including 60 male underground workers( 45- 55 years old) and 60 male upground workers( 45- 55 years old). The levels of vitamin D and bone mineral density of the lumbar spine and the hip were detected to compare the occurrence of osteoporosis between coal miners under different working environment. Results The basic situation including age,working time,body mass index,smoking,alcohol drinking,calcium,alkaline phosphatase,and blood urea nitrogen between the two groups were consistent and comparable. Serum parathyroid hormone in the upground workers were lower than those in the underground workers( P < 0. 05),but the vitamin D,and bone mineral density of the lumbar spine and femoral neck in the upground workers were higher than those in the underground workers( P <0. 05). The incidence of osteoporosis and osteopenia was 8. 3% and 40% in the underground miners,and 5% and 26. 7% in the upground miners,respectively. The vitamin D deficiency and insufficiency accounted for 85% and 10% in the underground miners,and 18. 3% and 11. 7% in the upground miners. Conclusion The levels vitamin D and bone mineral density were lower in the underground miners than in the upground miners. [ABSTRACT FROM AUTHOR]